SLC6A14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)8.17628553
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.46848038
3maintenance of gastrointestinal epithelium (GO:0030277)7.27598498
4intestinal epithelial cell development (GO:0060576)6.72648036
5surfactant homeostasis (GO:0043129)6.65838740
6hemidesmosome assembly (GO:0031581)6.22250888
7bile acid and bile salt transport (GO:0015721)6.12396860
8diterpenoid biosynthetic process (GO:0016102)6.07438870
9desmosome organization (GO:0002934)6.04555846
10epithelial structure maintenance (GO:0010669)5.98053791
11vitamin transmembrane transport (GO:0035461)5.82847832
12negative regulation of complement activation (GO:0045916)5.82690974
13O-glycan processing (GO:0016266)5.50320762
14chemical homeostasis within a tissue (GO:0048875)5.45157339
15negative regulation of protein activation cascade (GO:2000258)5.38765308
16negative regulation of humoral immune response (GO:0002921)5.24207304
17pyrimidine-containing compound transmembrane transport (GO:0072531)5.05574735
18calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.92825349
19sulfur amino acid catabolic process (GO:0000098)4.78969746
20regulation of water loss via skin (GO:0033561)4.69772950
21terpenoid biosynthetic process (GO:0016114)4.68540371
22regulation of complement activation (GO:0030449)4.50394401
23positive regulation of glycoprotein biosynthetic process (GO:0010560)4.43992149
24sulfate transmembrane transport (GO:1902358)4.37034334
25establishment of skin barrier (GO:0061436)4.36141140
26cellular response to vitamin D (GO:0071305)4.34678412
27axonemal dynein complex assembly (GO:0070286)4.21790137
28regulation of protein activation cascade (GO:2000257)4.21586453
29iron ion import (GO:0097286)4.20805165
30retinol metabolic process (GO:0042572)4.13913641
31hypotonic response (GO:0006971)4.13719541
32multicellular organismal water homeostasis (GO:0050891)4.12809814
33retinal metabolic process (GO:0042574)4.09861343
34actin filament depolymerization (GO:0030042)4.06899217
35cell adhesion mediated by integrin (GO:0033627)4.05492823
36complement activation, classical pathway (GO:0006958)4.02899250
37lung secretory cell differentiation (GO:0061140)4.01114310
38keratinization (GO:0031424)4.00338183
39positive regulation of glycoprotein metabolic process (GO:1903020)3.98620487
40positive regulation of keratinocyte differentiation (GO:0045618)3.91456421
41artery development (GO:0060840)3.90061390
42renal system process involved in regulation of blood volume (GO:0001977)3.85111743
43ventricular cardiac muscle cell action potential (GO:0086005)3.81332731
44trivalent inorganic anion homeostasis (GO:0072506)3.80137041
45phosphate ion homeostasis (GO:0055062)3.80137041
46ganglion development (GO:0061548)3.80124331
47tight junction assembly (GO:0070830)3.77118060
48gap junction assembly (GO:0016264)3.75076776
49regulation of keratinocyte differentiation (GO:0045616)3.73955704
50regulation of protein glycosylation (GO:0060049)3.70724043
51regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.67026456
52macrophage chemotaxis (GO:0048246)3.65379421
53mesenchymal-epithelial cell signaling (GO:0060638)3.64919078
54cilium or flagellum-dependent cell motility (GO:0001539)3.63976546
55nucleotide-sugar biosynthetic process (GO:0009226)3.63636477
56complement activation (GO:0006956)3.63138859
57establishment of planar polarity (GO:0001736)3.62528472
58establishment of tissue polarity (GO:0007164)3.62528472
59water homeostasis (GO:0030104)3.60790179
60regulation of transforming growth factor beta1 production (GO:0032908)3.59121283
61positive regulation of epidermal cell differentiation (GO:0045606)3.57266795
62positive regulation of vesicle fusion (GO:0031340)3.56812268
63negative regulation of axon extension involved in axon guidance (GO:0048843)3.53802371
64sulfate transport (GO:0008272)3.49551471
65fibrinolysis (GO:0042730)3.47042682
66diol metabolic process (GO:0034311)3.43002123
67positive regulation of actin filament depolymerization (GO:0030836)3.41341432
68negative regulation of keratinocyte proliferation (GO:0010839)3.40585417
69substrate-dependent cell migration (GO:0006929)3.39136998
70renal filtration (GO:0097205)3.38006753
71membrane budding (GO:0006900)3.36828630
72hepatocyte apoptotic process (GO:0097284)3.36591785
73protein O-linked glycosylation (GO:0006493)3.36083913
74epidermis development (GO:0008544)3.34080767
75Golgi transport vesicle coating (GO:0048200)3.33119317
76COPI coating of Golgi vesicle (GO:0048205)3.33119317
77striated muscle atrophy (GO:0014891)3.32325740
78facial nerve structural organization (GO:0021612)3.31112309
79nucleotide-sugar metabolic process (GO:0009225)3.30150508
80phosphatidylcholine biosynthetic process (GO:0006656)3.26698828
81cell communication involved in cardiac conduction (GO:0086065)3.25571119
82glomerular filtration (GO:0003094)3.25534511
83hair cycle (GO:0042633)3.25223987
84molting cycle (GO:0042303)3.25223987
85endothelial cell chemotaxis (GO:0035767)3.25100056
86axon extension involved in axon guidance (GO:0048846)3.23781760
87neuron projection extension involved in neuron projection guidance (GO:1902284)3.23781760
88positive regulation of transforming growth factor beta production (GO:0071636)3.23197546
89cellular response to nitric oxide (GO:0071732)3.22409632
90keratinocyte differentiation (GO:0030216)3.22160090
91sphingomyelin metabolic process (GO:0006684)3.20675096
923-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.18709585
93purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.18709585
94protein autoprocessing (GO:0016540)3.17223622
95regulation of bile acid biosynthetic process (GO:0070857)3.16636494
96protein localization to endosome (GO:0036010)3.16363565
97phosphate ion transmembrane transport (GO:0035435)3.16176333
98kidney morphogenesis (GO:0060993)3.16015272
99thrombin receptor signaling pathway (GO:0070493)3.15999562
100keratinocyte development (GO:0003334)3.15673721
101interferon-gamma secretion (GO:0072643)3.14430001
102cilium movement (GO:0003341)3.12256329
103complement activation, alternative pathway (GO:0006957)3.11444211
104protein activation cascade (GO:0072376)3.11356333
105sphingoid metabolic process (GO:0046519)3.11151887
106flavonoid metabolic process (GO:0009812)3.10767232
107sulfur compound transport (GO:0072348)3.10187872
108digestive system process (GO:0022600)3.09717260
109sphingosine metabolic process (GO:0006670)3.08849108
110regulation of humoral immune response (GO:0002920)3.07769616
111intestinal absorption (GO:0050892)3.07592230
112one-carbon compound transport (GO:0019755)3.07285570
113retinoic acid metabolic process (GO:0042573)3.06362972
114regulation of chemokine secretion (GO:0090196)3.05749146
115primary alcohol catabolic process (GO:0034310)3.05477417
116regulation of apoptotic cell clearance (GO:2000425)3.05447167
117negative regulation of protein tyrosine kinase activity (GO:0061099)3.05206766
118skeletal muscle adaptation (GO:0043501)3.01670814
119bicarbonate transport (GO:0015701)3.00996162
120retina homeostasis (GO:0001895)3.00586481
121regulation of transforming growth factor beta production (GO:0071634)3.00482712
122lung lobe morphogenesis (GO:0060463)2.99649737
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.97863606
124cellular anion homeostasis (GO:0030002)2.95504822
125epithelial cell-cell adhesion (GO:0090136)2.94073401
126renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.92884761
127cellular response to vitamin (GO:0071295)2.92826934
128primary alcohol metabolic process (GO:0034308)2.92103393
129sulfation (GO:0051923)2.89054506
130peptide cross-linking (GO:0018149)2.88560504
131positive regulation of interleukin-1 secretion (GO:0050716)2.86884491
132positive regulation of p38MAPK cascade (GO:1900745)2.86146317
133chaperone mediated protein folding requiring cofactor (GO:0051085)2.83628178
134regulation of keratinocyte proliferation (GO:0010837)2.83543673
135hepatocyte differentiation (GO:0070365)2.82148845
136glandular epithelial cell differentiation (GO:0002067)2.81519598
137glycosylceramide metabolic process (GO:0006677)2.81346086
138L-fucose catabolic process (GO:0042355)2.81164830
139fucose catabolic process (GO:0019317)2.81164830
140L-fucose metabolic process (GO:0042354)2.81164830
141regulation of glomerular filtration (GO:0003093)2.81136607
142branching involved in labyrinthine layer morphogenesis (GO:0060670)2.79695932
143copper ion transport (GO:0006825)2.79665514
144epidermal cell differentiation (GO:0009913)2.79197586
145intestinal cholesterol absorption (GO:0030299)2.78779599
146COPII vesicle coating (GO:0048208)2.78140055
147negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.76366546
148peptidyl-tyrosine autophosphorylation (GO:0038083)2.76166077
149amyloid precursor protein catabolic process (GO:0042987)2.75683433
150transcytosis (GO:0045056)2.74174633
151negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.73317022
152mesodermal cell differentiation (GO:0048333)2.72558397
153regulation of cardioblast differentiation (GO:0051890)2.72494398
154cGMP-mediated signaling (GO:0019934)2.71811867
155oligosaccharide biosynthetic process (GO:0009312)2.71572218
156regulation of cell proliferation involved in kidney development (GO:1901722)2.70956761
157positive regulation of epidermis development (GO:0045684)2.68628528
158cardiac conduction (GO:0061337)2.67629008
159production of molecular mediator of immune response (GO:0002440)2.66810824
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66713467
161ectoderm development (GO:0007398)2.66356788
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66274856
163neurotransmitter biosynthetic process (GO:0042136)2.65898551
164keratinocyte proliferation (GO:0043616)2.64495732
165branching involved in prostate gland morphogenesis (GO:0060442)2.64278043
166negative regulation of cell fate commitment (GO:0010454)2.63764331
167muscle atrophy (GO:0014889)2.62818968
168skin morphogenesis (GO:0043589)2.62667465
169regulation of interleukin-1 secretion (GO:0050704)2.62168709
170columnar/cuboidal epithelial cell development (GO:0002066)2.61716131
171regulation of heart rate by cardiac conduction (GO:0086091)2.61541555
172positive regulation of Cdc42 GTPase activity (GO:0043089)2.61007167
173ethanol metabolic process (GO:0006067)2.59971761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.75701277
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.79924088
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.38614058
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.28534334
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.20909905
6CDX2_19796622_ChIP-Seq_MESCs_Mouse3.01439171
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.87959216
8SOX2_20726797_ChIP-Seq_SW620_Human2.87830273
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.75541003
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.54550105
11GATA4_25053715_ChIP-Seq_YYC3_Human2.47209570
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.43921190
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.24175722
14GATA6_25053715_ChIP-Seq_YYC3_Human2.24145305
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.17401703
16FOXO3_23340844_ChIP-Seq_DLD1_Human2.13285279
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09851153
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07335315
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93889287
20RUNX1_27514584_Chip-Seq_MCF-7_Human1.91064642
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.89611145
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86913080
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86743734
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86743734
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85322454
26KLF5_25053715_ChIP-Seq_YYC3_Human1.79641369
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78119924
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.77065377
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75837720
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71663607
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71016720
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69964287
33RACK7_27058665_Chip-Seq_MCF-7_Human1.63300110
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57719419
35FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57461364
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56002447
37CLOCK_20551151_ChIP-Seq_293T_Human1.53487166
38ZNF263_19887448_ChIP-Seq_K562_Human1.52873838
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52792532
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47249166
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46578914
42* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44159983
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42177428
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42154014
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42116288
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.41968970
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41889470
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41168772
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40734409
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38572405
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36859007
52* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35757503
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.34951148
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34234088
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32890306
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31239881
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31048209
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30931014
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30745127
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30728977
61AHR_22903824_ChIP-Seq_MCF-7_Human1.28080285
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23776151
63ATF3_27146783_Chip-Seq_COLON_Human1.23501680
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.21812224
65AR_21909140_ChIP-Seq_LNCAP_Human1.20510613
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.20073943
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18751384
68CJUN_26792858_Chip-Seq_BT549_Human1.17544693
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17527370
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17410637
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.15418927
72FOXA1_25552417_ChIP-Seq_VCAP_Human1.14665674
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14665539
74ER_23166858_ChIP-Seq_MCF-7_Human1.14400915
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14308683
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.13139988
77GATA1_22025678_ChIP-Seq_K562_Human1.11324911
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09102359
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08896552
80RXR_22108803_ChIP-Seq_LS180_Human1.08846840
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08539680
82TP53_16413492_ChIP-PET_HCT116_Human1.07661345
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07010559
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07010559
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06119717
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05970850
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04992110
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04489398
89ELF5_23300383_ChIP-Seq_T47D_Human1.02397245
90BCAT_22108803_ChIP-Seq_LS180_Human0.97520531
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97256275
92FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96872957
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.96340606
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96205515
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95378814
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94416947
97GATA2_19941826_ChIP-Seq_K562_Human0.92629787
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92006218
99TP53_18474530_ChIP-ChIP_U2OS_Human0.90871117
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.90716506
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89984524
102TP63_23658742_ChIP-Seq_EP156T_Human0.89176813
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87686247
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87533281
105CDX2_22108803_ChIP-Seq_LS180_Human0.87192339
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86912128
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86794305
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86690197
109CREB1_26743006_Chip-Seq_LNCaP_Human0.86425447
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84396063
111TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83049908
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81685552
113DROSHA_22980978_ChIP-Seq_HELA_Human0.81143487
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79667626
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.77882266
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.77747293
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77449453
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75975602
119NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75782898
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.75608552
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75466360
122VDR_22108803_ChIP-Seq_LS180_Human0.75333808
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.75246214
124TP63_22573176_ChIP-Seq_HFKS_Human0.75053304
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73843652
126SALL1_21062744_ChIP-ChIP_HESCs_Human0.73654734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.50884520
2MP0003878_abnormal_ear_physiology3.38878028
3MP0005377_hearing/vestibular/ear_phenot3.38878028
4MP0002796_impaired_skin_barrier3.30423454
5MP0002822_catalepsy3.25595874
6MP0003866_abnormal_defecation3.21289943
7MP0004264_abnormal_extraembryonic_tissu3.13008038
8MP0004782_abnormal_surfactant_physiolog2.74257087
9MP0003941_abnormal_skin_development2.74111332
10MP0005167_abnormal_blood-brain_barrier2.62964171
11MP0005257_abnormal_intraocular_pressure2.57457282
12MP0005085_abnormal_gallbladder_physiolo2.53021494
13MP0000537_abnormal_urethra_morphology2.51774266
14MP0010155_abnormal_intestine_physiology2.51400322
15MP0006054_spinal_hemorrhage2.50381810
16MP0010678_abnormal_skin_adnexa2.42455944
17MP0001873_stomach_inflammation2.39526361
18MP0001666_abnormal_nutrient_absorption2.36592089
19MP0000462_abnormal_digestive_system2.33299499
20MP0008875_abnormal_xenobiotic_pharmacok2.30025835
21MP0001663_abnormal_digestive_system2.28087727
22MP0003191_abnormal_cellular_cholesterol2.19228282
23MP0005381_digestive/alimentary_phenotyp2.15761294
24MP0005275_abnormal_skin_tensile2.06121850
25MP0003705_abnormal_hypodermis_morpholog1.99665868
26MP0010352_gastrointestinal_tract_polyps1.97508671
27MP0005501_abnormal_skin_physiology1.90013840
28MP0001664_abnormal_digestion1.88264266
29MP0000566_synostosis1.85581811
30MP0000490_abnormal_crypts_of1.80701736
31MP0002060_abnormal_skin_morphology1.75103722
32MP0000477_abnormal_intestine_morphology1.73680951
33MP0003453_abnormal_keratinocyte_physiol1.71487848
34MP0000427_abnormal_hair_cycle1.68385435
35MP0002098_abnormal_vibrissa_morphology1.67891429
36MP0000465_gastrointestinal_hemorrhage1.64808338
37MP0001216_abnormal_epidermal_layer1.64082068
38MP0005365_abnormal_bile_salt1.59156729
39MP0003300_gastrointestinal_ulcer1.58984474
40MP0001958_emphysema1.58639679
41MP0003868_abnormal_feces_composition1.56238366
42MP0004947_skin_inflammation1.54745971
43MP0001765_abnormal_ion_homeostasis1.45943060
44MP0009384_cardiac_valve_regurgitation1.43215815
45MP0001849_ear_inflammation1.41772636
46MP0000383_abnormal_hair_follicle1.41573072
47MP0000467_abnormal_esophagus_morphology1.41531865
48MP0004381_abnormal_hair_follicle1.41531391
49MP0003950_abnormal_plasma_membrane1.37031844
50MP0000367_abnormal_coat/_hair1.30802664
51MP0002277_abnormal_respiratory_mucosa1.30046864
52MP0005058_abnormal_lysosome_morphology1.29177202
53MP0005165_increased_susceptibility_to1.26782585
54MP0004185_abnormal_adipocyte_glucose1.24215555
55MP0003566_abnormal_cell_adhesion1.23737113
56MP0002254_reproductive_system_inflammat1.22288976
57MP0010771_integument_phenotype1.17664639
58MP0000579_abnormal_nail_morphology1.16425608
59MP0000377_abnormal_hair_follicle1.10852349
60MP0003806_abnormal_nucleotide_metabolis1.09439147
61MP0001881_abnormal_mammary_gland1.08621299
62MP0002166_altered_tumor_susceptibility1.05491541
63MP0000762_abnormal_tongue_morphology1.04255619
64MP0000470_abnormal_stomach_morphology1.03152959
65MP0005076_abnormal_cell_differentiation1.02933138
66MP0009643_abnormal_urine_homeostasis1.01902308
67MP0005197_abnormal_uvea_morphology0.99626348
68MP0009840_abnormal_foam_cell0.98863247
69MP0003656_abnormal_erythrocyte_physiolo0.98800378
70MP0005166_decreased_susceptibility_to0.98109733
71MP0002138_abnormal_hepatobiliary_system0.96985188
72MP0002282_abnormal_trachea_morphology0.94151982
73MP0005636_abnormal_mineral_homeostasis0.94032013
74MP0000538_abnormal_urinary_bladder0.92278486
75MP0004043_abnormal_pH_regulation0.91967983
76MP0005083_abnormal_biliary_tract0.91068918
77MP0004272_abnormal_basement_membrane0.88277478
78MP0003075_altered_response_to0.87254708
79MP0001243_abnormal_dermal_layer0.86134959
80MP0008004_abnormal_stomach_pH0.85921151
81MP0005248_abnormal_Harderian_gland0.84460675
82MP0002132_abnormal_respiratory_system0.84390954
83MP0001191_abnormal_skin_condition0.84343480
84MP0005409_darkened_coat_color0.82898796
85MP0003724_increased_susceptibility_to0.82850046
86MP0005408_hypopigmentation0.82605042
87MP0003329_amyloid_beta_deposits0.81626835
88MP0004019_abnormal_vitamin_homeostasis0.80659352
89MP0001756_abnormal_urination0.80346298
90MP0000678_abnormal_parathyroid_gland0.79912600
91MP0000013_abnormal_adipose_tissue0.79859831
92MP0001502_abnormal_circadian_rhythm0.79399761
93MP0005310_abnormal_salivary_gland0.76815396
94MP0003091_abnormal_cell_migration0.76025346
95MP0003045_fibrosis0.75895926
96MP0002896_abnormal_bone_mineralization0.74154786
97MP0005451_abnormal_body_composition0.74044294
98MP0000647_abnormal_sebaceous_gland0.73644054
99MP0002234_abnormal_pharynx_morphology0.73603236
100MP0003252_abnormal_bile_duct0.72631043
101MP0005023_abnormal_wound_healing0.71397248
102MP0000858_altered_metastatic_potential0.70644453
103MP0003283_abnormal_digestive_organ0.69433211
104MP0005367_renal/urinary_system_phenotyp0.68903964
105MP0000516_abnormal_urinary_system0.68903964
106MP0002136_abnormal_kidney_physiology0.68569905
107MP0004883_abnormal_blood_vessel0.68343253
108MP0001177_atelectasis0.68013006
109MP0005388_respiratory_system_phenotype0.67672732
110MP0002133_abnormal_respiratory_system0.67672732
111MP0004484_altered_response_of0.66869492
112MP0003638_abnormal_response/metabolism_0.66509057
113MP0005187_abnormal_penis_morphology0.66032591
114MP0009379_abnormal_foot_pigmentation0.63907011
115MP0009931_abnormal_skin_appearance0.63213643
116MP0002006_tumorigenesis0.62927413
117MP0000249_abnormal_blood_vessel0.62890383
118MP0001533_abnormal_skeleton_physiology0.62553305
119MP0009785_altered_susceptibility_to0.62091340
120MP0002877_abnormal_melanocyte_morpholog0.61642961
121MP0002876_abnormal_thyroid_physiology0.60424601
122MP0003936_abnormal_reproductive_system0.60373974
123MP0004885_abnormal_endolymph0.59210324
124MP0004147_increased_porphyrin_level0.58761696
125MP0008995_early_reproductive_senescence0.58676326
126MP0009780_abnormal_chondrocyte_physiolo0.58355231
127MP0001542_abnormal_bone_strength0.57386739
128MP0010368_abnormal_lymphatic_system0.57137744
129MP0001851_eye_inflammation0.56451946
130MP0000627_abnormal_mammary_gland0.55929411
131MP0005387_immune_system_phenotype0.55259177
132MP0001790_abnormal_immune_system0.55259177
133MP0002295_abnormal_pulmonary_circulatio0.53812267
134MP0003315_abnormal_perineum_morphology0.53725322
135MP0005164_abnormal_response_to0.53571148
136MP0008260_abnormal_autophagy0.50709389
137MP0010386_abnormal_urinary_bladder0.50477351
138MP0002148_abnormal_hypersensitivity_rea0.49057392
139MP0002118_abnormal_lipid_homeostasis0.47893922

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.40863202
2Hyperactive renin-angiotensin system (HP:0000841)7.35676261
3Ileus (HP:0002595)5.66722484
4Onycholysis (HP:0001806)5.64356496
5Malnutrition (HP:0004395)4.57072581
6Milia (HP:0001056)4.42525614
7Abnormality of chloride homeostasis (HP:0011422)4.37249730
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.34086668
9Prostate neoplasm (HP:0100787)4.23293890
10Metabolic alkalosis (HP:0200114)4.19948698
11Fragile nails (HP:0001808)4.06889317
12Plantar hyperkeratosis (HP:0007556)4.03382738
13Flat acetabular roof (HP:0003180)4.01710862
14Abnormality of renin-angiotensin system (HP:0000847)3.97780944
15Pustule (HP:0200039)3.87876236
16Rhinitis (HP:0012384)3.81796600
17Oral leukoplakia (HP:0002745)3.81402377
18Villous atrophy (HP:0011473)3.78725856
19Abnormality of small intestinal villus morphology (HP:0011472)3.78725856
20Abnormal respiratory motile cilium physiology (HP:0012261)3.67811939
21Decreased circulating renin level (HP:0003351)3.63890283
22Conjugated hyperbilirubinemia (HP:0002908)3.61841236
23Erythema (HP:0010783)3.61483913
24Atrophic scars (HP:0001075)3.59730173
25Abnormal ciliary motility (HP:0012262)3.51490076
26Interstitial pulmonary disease (HP:0006530)3.50374980
27Abnormal respiratory epithelium morphology (HP:0012253)3.43920358
28Abnormal respiratory motile cilium morphology (HP:0005938)3.43920358
29Hyperaldosteronism (HP:0000859)3.43680031
30Woolly hair (HP:0002224)3.35640561
31Pili torti (HP:0003777)3.34411259
32Abdominal distention (HP:0003270)3.33541310
33Erythroderma (HP:0001019)3.27330249
34Sparse eyelashes (HP:0000653)3.24674010
35Dehydration (HP:0001944)3.20267137
36Dynein arm defect of respiratory motile cilia (HP:0012255)3.18843655
37Absent/shortened dynein arms (HP:0200106)3.18843655
38Alopecia of scalp (HP:0002293)3.13528893
39Mildly elevated creatine phosphokinase (HP:0008180)3.11974222
40Parakeratosis (HP:0001036)2.99001298
41Vascular calcification (HP:0004934)2.96063009
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.94108074
43Hypotrichosis (HP:0001006)2.93513543
44Ventricular tachycardia (HP:0004756)2.89521234
45Congenital ichthyosiform erythroderma (HP:0007431)2.89362054
46Bronchiectasis (HP:0002110)2.84046899
47Aortic aneurysm (HP:0004942)2.81757401
48Lip pit (HP:0100267)2.81575333
49Chronic diarrhea (HP:0002028)2.80724035
50Abnormality of the distal phalanx of the thumb (HP:0009617)2.79214578
51Curly hair (HP:0002212)2.76447052
52Glomerulonephritis (HP:0000099)2.72697397
53Palmoplantar hyperkeratosis (HP:0000972)2.71390416
54Biliary tract neoplasm (HP:0100574)2.70034573
55Deep venous thrombosis (HP:0002625)2.67024574
56Abnormal biliary tract morphology (HP:0012440)2.65451242
57Hoarse voice (HP:0001609)2.65358739
58Abnormality of nail color (HP:0100643)2.65049559
59Epidermoid cyst (HP:0200040)2.62529214
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.59222190
61Complement deficiency (HP:0004431)2.56776998
62Chronic bronchitis (HP:0004469)2.56586508
63Gastrointestinal dysmotility (HP:0002579)2.56065734
64Palmar hyperkeratosis (HP:0010765)2.52882583
65Micronodular cirrhosis (HP:0001413)2.50820752
66Abnormality of the 1st metacarpal (HP:0010009)2.49600209
67Cardiovascular calcification (HP:0011915)2.49318966
68Hypoplasia of dental enamel (HP:0006297)2.47362151
69Popliteal pterygium (HP:0009756)2.44561882
70Abnormal cartilage morphology (HP:0002763)2.43279024
71Hyponatremia (HP:0002902)2.42899805
72Increased IgE level (HP:0003212)2.37158249
73Neonatal short-limb short stature (HP:0008921)2.36180259
74Follicular hyperkeratosis (HP:0007502)2.33456472
75Ectropion (HP:0000656)2.33370507
76Thin bony cortex (HP:0002753)2.32751515
77Abnormal blistering of the skin (HP:0008066)2.31037913
78Nail dystrophy (HP:0008404)2.30187323
79Abnormal tarsal ossification (HP:0008369)2.28692597
80Intrahepatic cholestasis (HP:0001406)2.28058506
81Rectal prolapse (HP:0002035)2.27864407
82Abnormality of the 2nd finger (HP:0004100)2.27168338
83Abnormality of the axillary hair (HP:0100134)2.26262789
84Abnormality of secondary sexual hair (HP:0009888)2.26262789
85Absent eyelashes (HP:0000561)2.24869291
86Hypoplastic labia majora (HP:0000059)2.24729777
87Furrowed tongue (HP:0000221)2.23382013
88Progressive sensorineural hearing impairment (HP:0000408)2.22420890
89Palpitations (HP:0001962)2.20406328
90Bronchitis (HP:0012387)2.19786112
91Hyperkalemia (HP:0002153)2.19506561
92Nephritis (HP:0000123)2.19412225
93Abnormality of the gastric mucosa (HP:0004295)2.18832641
94Cone-rod dystrophy (HP:0000548)2.18594845
95Tubulointerstitial fibrosis (HP:0005576)2.16904007
96Visceral angiomatosis (HP:0100761)2.16581063
97Alkalosis (HP:0001948)2.16012060
98Aortic dissection (HP:0002647)2.14912676
99Palmoplantar keratoderma (HP:0000982)2.14851207
100Esophageal varix (HP:0002040)2.14083444
101Syncope (HP:0001279)2.14029541
102Renal salt wasting (HP:0000127)2.12259733
103Ventricular fibrillation (HP:0001663)2.10110175
104Short hallux (HP:0010109)2.08528974
105Blepharitis (HP:0000498)2.08116908
106Vacuolated lymphocytes (HP:0001922)2.07102576
107Nasal polyposis (HP:0100582)2.07043483
108Abnormality of the labia majora (HP:0012881)2.06409653
109Broad metatarsal (HP:0001783)2.04762939
110Pruritus (HP:0000989)2.04304124
111Hypokalemia (HP:0002900)2.00071765
112Abnormal foot bone ossification (HP:0010675)1.98583250
113Thick nail (HP:0001805)1.98432602
114Abnormality of complement system (HP:0005339)1.97632606
115Corneal erosion (HP:0200020)1.97245779
116Abnormality of potassium homeostasis (HP:0011042)1.96375130
117Septate vagina (HP:0001153)1.96293335
118Arterial tortuosity (HP:0005116)1.95551992
119Ureteral stenosis (HP:0000071)1.94519665
120Abnormal vertebral ossification (HP:0100569)1.94022271
121Joint hemorrhage (HP:0005261)1.93893681
122Aplasia/Hypoplasia of the hallux (HP:0008362)1.93323902
123Systemic lupus erythematosus (HP:0002725)1.93136320
124Abnormality of sodium homeostasis (HP:0010931)1.93134446
125Hypohidrosis (HP:0000966)1.92861001
126Hemangiomatosis (HP:0007461)1.92747739
127Pterygium (HP:0001059)1.92703286
128Corneal dystrophy (HP:0001131)1.92196018
129Fat malabsorption (HP:0002630)1.91101169
130Ridged nail (HP:0001807)1.89556958
131Short 1st metacarpal (HP:0010034)1.89482673
132Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89482673
133Microglossia (HP:0000171)1.87707534
134Toxemia of pregnancy (HP:0100603)1.86976972
135Petechiae (HP:0000967)1.86849787
136Gangrene (HP:0100758)1.86267580
137Small epiphyses (HP:0010585)1.85090509
138Ulnar bowing (HP:0003031)1.85000274
139Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84770742
140Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83767112
141Vertebral hypoplasia (HP:0008417)1.83767112
142Gout (HP:0001997)1.81838183
143Amniotic constriction ring (HP:0009775)1.81696547
144Abnormality of placental membranes (HP:0011409)1.81696547
145Abnormality of permanent molar morphology (HP:0011071)1.81653621
146Abnormality of the dental root (HP:0006486)1.81653621
147Taurodontia (HP:0000679)1.81653621
148Absent frontal sinuses (HP:0002688)1.81454751
149Papillary thyroid carcinoma (HP:0002895)1.81042702
150Abnormality of the distal phalanges of the toes (HP:0010182)1.79920399
151Tubulointerstitial nephritis (HP:0001970)1.79405303
152Flattened epiphyses (HP:0003071)1.79348639
153Focal segmental glomerulosclerosis (HP:0000097)1.79039807
154Hyperuricemia (HP:0002149)1.78827986
155Increased purine levels (HP:0004368)1.78827986
156Abnormality of the dental pulp (HP:0006479)1.78813393
157Glomerulosclerosis (HP:0000096)1.78739719
158Ureteral obstruction (HP:0006000)1.78522520
159Hematochezia (HP:0002573)1.77992842
160Fragile skin (HP:0001030)1.77683672
161Abnormal hair laboratory examination (HP:0003328)1.77395612
162Progressive hearing impairment (HP:0001730)1.76492205
163Osteolytic defects of the hand bones (HP:0009699)1.75575302
164Osteolytic defects of the phalanges of the hand (HP:0009771)1.75575302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.78611770
2PIK3CA5.47766261
3MAP3K24.07757377
4FRK3.96570520
5MST43.18167095
6LMTK23.03700396
7KSR23.01452615
8MET2.94678273
9TESK12.76406948
10MAP2K22.73662934
11EPHA22.62195877
12MYLK2.51853523
13RIPK12.15390314
14NME12.11024844
15MAPK151.97619779
16NEK61.90331734
17EIF2AK31.81266894
18EPHB21.67971031
19MAP2K11.67964265
20MAP3K31.62994528
21LIMK11.56282316
22FER1.54015647
23STK38L1.48116713
24SCYL21.42838487
25MUSK1.33059611
26PRKG21.31575081
27BMPR1B1.31375307
28PTK61.28483272
29EIF2AK11.26412907
30BRSK21.25136960
31STK101.24717495
32MAP3K11.24680152
33EPHB11.20679996
34JAK11.18229965
35SIK11.16113199
36TAOK11.14846369
37DDR21.07961004
38PTK21.02356209
39BMPR21.00064806
40PAK40.96964265
41RPS6KB20.92667833
42DMPK0.92630739
43TTN0.91868112
44MAPKAPK30.91752819
45TGFBR20.91021780
46CHUK0.90955361
47LRRK20.88973340
48MAP3K120.88120426
49EEF2K0.88066419
50NUAK10.85244621
51GRK70.83537383
52FGFR20.82893696
53MAP3K80.80191588
54TRPM70.79669857
55ERBB20.76378840
56DAPK20.76110589
57LATS10.75151698
58CAMK2D0.75102417
59OXSR10.72720851
60YES10.71551176
61MAP3K110.69777012
62PDK20.68685878
63CSF1R0.61064309
64RPS6KB10.60153160
65SIK30.60135414
66PRKCE0.57930773
67STK380.57618790
68TRIM280.56534881
69IGF1R0.55557642
70GRK10.53147727
71EPHA30.52896710
72PRKCI0.52535138
73BMX0.52479421
74ITK0.51559135
75PIK3CG0.51526089
76ADRBK10.50837194
77TIE10.49867803
78ABL10.49803065
79IKBKB0.49597827
80IRAK10.49443609
81STK390.48433340
82MATK0.48022632
83IKBKE0.47357485
84TAOK20.47352124
85RET0.46895581
86MAP2K30.46440103
87PBK0.46091527
88FGFR40.45869811
89WNK40.44970598
90WNK10.44876467
91CDK80.44224087
92TBK10.40981234
93PDGFRB0.40817998
94STK240.39923299
95RIPK40.39453584
96CAMKK20.37666566
97PAK20.37267187
98MAP3K90.35547173
99EIF2AK20.34565374
100ROCK10.34028579
101BCR0.33632799
102TSSK60.33455339
103AURKB0.33174201
104ERBB40.32896902
105PRKAA20.32344895
106CDK90.31912334
107PAK30.30281198
108PRKCD0.30099085
109FGFR30.29520117
110ERBB30.28826119
111CDK60.28816106
112TRIB30.27363844
113TAOK30.25411980
114DAPK30.24935139
115STK30.24473488
116EPHA40.24422495
117NTRK10.24369571
118ILK0.24123719
119ADRBK20.23711045
120MAP2K60.23495272
121EGFR0.22720340
122MAP3K70.22539287
123LATS20.22307900
124PDK30.21969950
125PDK40.21969950
126SRC0.21905501
127GSK3A0.21400318
128INSR0.21394577
129BRSK10.21376344
130TYK20.20377235
131CSK0.20108305
132GRK60.19615041
133PRKCA0.18935634
134ROCK20.18631510
135MAPKAPK20.18417717
136CAMK2G0.17207340
137PDPK10.15529440
138FGFR10.15492199
139FYN0.15481913
140MAPK110.15083975
141TGFBR10.15005862
142PDGFRA0.14865059
143PAK10.13648450
144JAK20.13094244
145CAMK2B0.12627342

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.03142212
2Mineral absorption_Homo sapiens_hsa049784.82354490
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.89116111
4Complement and coagulation cascades_Homo sapiens_hsa046103.25264607
5Staphylococcus aureus infection_Homo sapiens_hsa051503.07778391
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.78549117
7Bile secretion_Homo sapiens_hsa049762.63982149
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.53977779
9Tight junction_Homo sapiens_hsa045302.34183070
10Asthma_Homo sapiens_hsa053102.22213659
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89670999
12Steroid biosynthesis_Homo sapiens_hsa001001.88632455
13Histidine metabolism_Homo sapiens_hsa003401.87174777
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85120253
15Adherens junction_Homo sapiens_hsa045201.79736792
16Allograft rejection_Homo sapiens_hsa053301.73446697
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65185721
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61783996
19Autoimmune thyroid disease_Homo sapiens_hsa053201.61771277
20Lysosome_Homo sapiens_hsa041421.60115229
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.56445942
22Graft-versus-host disease_Homo sapiens_hsa053321.55649211
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53541320
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53080131
25Bladder cancer_Homo sapiens_hsa052191.52677853
26Fatty acid biosynthesis_Homo sapiens_hsa000611.52405972
27Thyroid cancer_Homo sapiens_hsa052161.51288307
28Caffeine metabolism_Homo sapiens_hsa002321.50564897
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.48822350
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46311635
31Arginine biosynthesis_Homo sapiens_hsa002201.43225535
32Salivary secretion_Homo sapiens_hsa049701.42156588
33Antigen processing and presentation_Homo sapiens_hsa046121.40585859
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38833890
35Tyrosine metabolism_Homo sapiens_hsa003501.37835919
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28153056
37Type I diabetes mellitus_Homo sapiens_hsa049401.27550776
38Circadian rhythm_Homo sapiens_hsa047101.26948374
39Pancreatic secretion_Homo sapiens_hsa049721.24522740
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24050807
41ECM-receptor interaction_Homo sapiens_hsa045121.22893713
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21269749
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.13761695
44Salmonella infection_Homo sapiens_hsa051321.13715907
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12918681
46Vibrio cholerae infection_Homo sapiens_hsa051101.11268569
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08909207
48Hepatitis C_Homo sapiens_hsa051601.07475122
49Amoebiasis_Homo sapiens_hsa051461.05150268
50Sphingolipid metabolism_Homo sapiens_hsa006001.04932895
51Chemical carcinogenesis_Homo sapiens_hsa052041.02043148
52Viral myocarditis_Homo sapiens_hsa054160.90550987
53Protein digestion and absorption_Homo sapiens_hsa049740.89903424
54Glutathione metabolism_Homo sapiens_hsa004800.89796973
55Tryptophan metabolism_Homo sapiens_hsa003800.88367420
56Renin-angiotensin system_Homo sapiens_hsa046140.87499920
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85982154
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.84885112
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84335178
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80676769
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80258884
62Focal adhesion_Homo sapiens_hsa045100.79623531
63Dorso-ventral axis formation_Homo sapiens_hsa043200.79527979
64ABC transporters_Homo sapiens_hsa020100.78322508
65Other glycan degradation_Homo sapiens_hsa005110.75105637
66Hippo signaling pathway_Homo sapiens_hsa043900.73706558
67Glycerolipid metabolism_Homo sapiens_hsa005610.73386439
68Nitrogen metabolism_Homo sapiens_hsa009100.73369051
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73305073
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.72521805
71Toxoplasmosis_Homo sapiens_hsa051450.72518260
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71885837
73Proteoglycans in cancer_Homo sapiens_hsa052050.71801625
74Phenylalanine metabolism_Homo sapiens_hsa003600.70996531
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69462644
76Gastric acid secretion_Homo sapiens_hsa049710.68557542
77Proteasome_Homo sapiens_hsa030500.68419135
78Rheumatoid arthritis_Homo sapiens_hsa053230.67814924
79Fructose and mannose metabolism_Homo sapiens_hsa000510.67477002
80Fatty acid degradation_Homo sapiens_hsa000710.66868761
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65663029
82Pertussis_Homo sapiens_hsa051330.65628584
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64296519
84Retinol metabolism_Homo sapiens_hsa008300.61059245
85Ovarian steroidogenesis_Homo sapiens_hsa049130.60843331
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60749065
87PPAR signaling pathway_Homo sapiens_hsa033200.60198449
88Peroxisome_Homo sapiens_hsa041460.59990625
89Galactose metabolism_Homo sapiens_hsa000520.58412261
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56963423
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.56660098
92Fat digestion and absorption_Homo sapiens_hsa049750.56062793
93Phagosome_Homo sapiens_hsa041450.55811441
94Small cell lung cancer_Homo sapiens_hsa052220.52112435
95N-Glycan biosynthesis_Homo sapiens_hsa005100.52060548
96TGF-beta signaling pathway_Homo sapiens_hsa043500.51741800
97Thyroid hormone synthesis_Homo sapiens_hsa049180.50452153
98Endometrial cancer_Homo sapiens_hsa052130.50374384
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49443577
100Linoleic acid metabolism_Homo sapiens_hsa005910.48575581
101Arginine and proline metabolism_Homo sapiens_hsa003300.48487459
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.48048554
103Starch and sucrose metabolism_Homo sapiens_hsa005000.45613806
104Platelet activation_Homo sapiens_hsa046110.45024604
105Vitamin digestion and absorption_Homo sapiens_hsa049770.43851437
106Shigellosis_Homo sapiens_hsa051310.43779018
107Tuberculosis_Homo sapiens_hsa051520.42603551
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.39200287
109VEGF signaling pathway_Homo sapiens_hsa043700.38342737
110Axon guidance_Homo sapiens_hsa043600.38141645
111Butanoate metabolism_Homo sapiens_hsa006500.38138755
112Influenza A_Homo sapiens_hsa051640.37614688
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36824275
114GnRH signaling pathway_Homo sapiens_hsa049120.36242599
115Leishmaniasis_Homo sapiens_hsa051400.35657757
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.34908737
117Hematopoietic cell lineage_Homo sapiens_hsa046400.32626107
118Arachidonic acid metabolism_Homo sapiens_hsa005900.32566164
119Choline metabolism in cancer_Homo sapiens_hsa052310.29923979
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29810705
121Renin secretion_Homo sapiens_hsa049240.29651345
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.28879280
123Endocytosis_Homo sapiens_hsa041440.28252668
124TNF signaling pathway_Homo sapiens_hsa046680.27931457
125Selenocompound metabolism_Homo sapiens_hsa004500.27679181
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27475290
127beta-Alanine metabolism_Homo sapiens_hsa004100.27314672
128African trypanosomiasis_Homo sapiens_hsa051430.27029374
129Chronic myeloid leukemia_Homo sapiens_hsa052200.26713858
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26380582
131Rap1 signaling pathway_Homo sapiens_hsa040150.26244465
132Herpes simplex infection_Homo sapiens_hsa051680.25627259
133Ether lipid metabolism_Homo sapiens_hsa005650.25147816
134Melanogenesis_Homo sapiens_hsa049160.24357687
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24175667
136Fatty acid elongation_Homo sapiens_hsa000620.23063221
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22499675
138Pathways in cancer_Homo sapiens_hsa052000.21856930
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21721072
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21565707

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