SLC6A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)6.58267793
2sodium ion export (GO:0071436)6.55929615
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65411167
4locomotory exploration behavior (GO:0035641)5.52679410
5synaptic vesicle maturation (GO:0016188)5.20422505
6L-amino acid import (GO:0043092)5.08947460
7potassium ion import (GO:0010107)5.05162945
8cellular sodium ion homeostasis (GO:0006883)5.02242975
9hemidesmosome assembly (GO:0031581)4.97205640
10cell communication by electrical coupling (GO:0010644)4.89594559
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.88564418
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.81385234
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74178531
14potassium ion homeostasis (GO:0055075)4.69093753
15vocalization behavior (GO:0071625)4.61504392
16amino acid import (GO:0043090)4.55334232
17neurotransmitter uptake (GO:0001504)4.50682673
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.49979414
19glutamate secretion (GO:0014047)4.36817656
20negative regulation of astrocyte differentiation (GO:0048712)4.31988432
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.30837349
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29671041
23regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.28524515
24synaptic vesicle exocytosis (GO:0016079)4.22923578
25alanine transport (GO:0032328)4.22906143
26neuron cell-cell adhesion (GO:0007158)4.22499362
27proline transport (GO:0015824)4.19329120
28regulation of synaptic vesicle exocytosis (GO:2000300)4.18713807
29* neurotransmitter secretion (GO:0007269)4.14479233
30regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14118462
31regulation of glutamate receptor signaling pathway (GO:1900449)4.12843468
32* gamma-aminobutyric acid transport (GO:0015812)4.10993014
33negative regulation of cytosolic calcium ion concentration (GO:0051481)4.06153958
34positive regulation of synapse maturation (GO:0090129)4.04021694
35regulation of neuronal synaptic plasticity (GO:0048168)4.03424259
36exploration behavior (GO:0035640)4.01173544
37response to auditory stimulus (GO:0010996)3.99602437
38glycine transport (GO:0015816)3.97185563
39layer formation in cerebral cortex (GO:0021819)3.91439507
40C4-dicarboxylate transport (GO:0015740)3.87840647
41neuronal action potential propagation (GO:0019227)3.84131932
42glutamate receptor signaling pathway (GO:0007215)3.83319823
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.83295620
44neurotransmitter-gated ion channel clustering (GO:0072578)3.80419540
45* neurotransmitter transport (GO:0006836)3.75866275
46regulation of synapse structural plasticity (GO:0051823)3.70004372
47regulation of synaptic vesicle transport (GO:1902803)3.69302265
48negative regulation of sodium ion transport (GO:0010766)3.68603812
49protein localization to synapse (GO:0035418)3.66852337
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.65359207
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.64967615
52auditory behavior (GO:0031223)3.64425644
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.62909179
54synaptic transmission, glutamatergic (GO:0035249)3.59279415
55regulation of respiratory system process (GO:0044065)3.56091169
56neuromuscular process controlling posture (GO:0050884)3.55507061
57presynaptic membrane organization (GO:0097090)3.52796083
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51172292
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50024978
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.47448212
61* regulation of neurotransmitter levels (GO:0001505)3.46610962
62axon ensheathment in central nervous system (GO:0032291)3.45051595
63central nervous system myelination (GO:0022010)3.45051595
64long-term memory (GO:0007616)3.44279619
65prepulse inhibition (GO:0060134)3.40851459
66mechanosensory behavior (GO:0007638)3.40050411
67cochlea development (GO:0090102)3.39622714
68postsynaptic membrane organization (GO:0001941)3.38093410
69acidic amino acid transport (GO:0015800)3.33389496
70positive regulation of potassium ion transmembrane transport (GO:1901381)3.31584639
71artery smooth muscle contraction (GO:0014824)3.29636149
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28377038
73transmission of nerve impulse (GO:0019226)3.26235433
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26136478
75dendritic spine morphogenesis (GO:0060997)3.26044045
76neuron-neuron synaptic transmission (GO:0007270)3.23241154
77regulation of synapse maturation (GO:0090128)3.20374512
78neuromuscular process controlling balance (GO:0050885)3.19395996
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16549794
80regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14233155
81activation of protein kinase A activity (GO:0034199)3.14220836
82regulation of dendritic spine morphogenesis (GO:0061001)3.12456170
83negative regulation of oligodendrocyte differentiation (GO:0048715)3.11744751
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.10571730
85regulation of respiratory gaseous exchange (GO:0043576)3.10555006
86dendrite morphogenesis (GO:0048813)3.09260265
87gamma-aminobutyric acid signaling pathway (GO:0007214)3.08773283
88cerebellar granule cell differentiation (GO:0021707)3.06121231
89L-glutamate transport (GO:0015813)3.02762960
90neuron recognition (GO:0008038)3.01200787
91positive regulation of dendritic spine development (GO:0060999)3.00651435
92membrane repolarization (GO:0086009)2.99312830
93behavioral response to cocaine (GO:0048148)2.99075725
94drinking behavior (GO:0042756)2.98865663
95cerebellar Purkinje cell differentiation (GO:0021702)2.97978794
96cell communication involved in cardiac conduction (GO:0086065)2.97956723
97negative regulation of glial cell differentiation (GO:0045686)2.97884719
98regulation of synaptic plasticity (GO:0048167)2.97323761
99sodium ion homeostasis (GO:0055078)2.95033556
100membrane depolarization during action potential (GO:0086010)2.93396668
101regulation of beta-amyloid formation (GO:1902003)2.92379204
102positive regulation of membrane potential (GO:0045838)2.91590918
103regulation of vesicle fusion (GO:0031338)2.90635492
104membrane hyperpolarization (GO:0060081)2.89883789
105innervation (GO:0060384)2.89689903
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89582113
107vascular smooth muscle contraction (GO:0014829)2.87718530
108axonal fasciculation (GO:0007413)2.86333422
109response to histamine (GO:0034776)2.85916864
110neuronal ion channel clustering (GO:0045161)2.84480222
111regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.81517416
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80818746
113regulation of postsynaptic membrane potential (GO:0060078)2.79147461
114regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78681799
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78402855
116presynaptic membrane assembly (GO:0097105)2.77392355
117long-term synaptic potentiation (GO:0060291)2.77116970
118tonic smooth muscle contraction (GO:0014820)2.69394986
119regulation of dendritic spine development (GO:0060998)2.61863828
120synapse assembly (GO:0007416)2.60169312
121regulation of astrocyte differentiation (GO:0048710)2.59997276
122cerebellar Purkinje cell layer development (GO:0021680)2.58969946
123startle response (GO:0001964)2.53074672
124neuromuscular synaptic transmission (GO:0007274)2.50740153
125desmosome organization (GO:0002934)2.48213346
126synaptic vesicle endocytosis (GO:0048488)2.47183920
127regulation of cholesterol biosynthetic process (GO:0045540)2.46870922
128membrane depolarization (GO:0051899)2.45560040
129neurotransmitter catabolic process (GO:0042135)2.45218066
130regulation of calcium ion-dependent exocytosis (GO:0017158)2.43654137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52730440
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.88694690
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13460556
4GBX2_23144817_ChIP-Seq_PC3_Human3.10176818
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00929187
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82990583
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71453817
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66522130
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66522130
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52815421
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52394868
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51973136
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.50784367
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48635056
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45958964
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.45742660
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.36306024
18* DROSHA_22980978_ChIP-Seq_HELA_Human2.33586217
19AR_21572438_ChIP-Seq_LNCaP_Human2.33555925
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21436671
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18283698
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.16373244
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.15826898
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13760779
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.13063636
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12856366
27* REST_18959480_ChIP-ChIP_MESCs_Mouse2.00066374
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90019553
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85311759
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82809601
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81320029
32IGF1R_20145208_ChIP-Seq_DFB_Human1.76287741
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75129146
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67335825
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64076945
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.62242846
37RNF2_27304074_Chip-Seq_NSC_Mouse1.56378745
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50078041
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46033680
40* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43277009
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42016198
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41820303
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.41687209
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41239448
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32797186
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.31604734
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30324832
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.26458567
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25770972
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.24398964
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24318811
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24234954
53* AR_19668381_ChIP-Seq_PC3_Human1.22000649
54ZNF274_21170338_ChIP-Seq_K562_Hela1.21768210
55AR_25329375_ChIP-Seq_VCAP_Human1.21148735
56P300_19829295_ChIP-Seq_ESCs_Human1.21101862
57VDR_22108803_ChIP-Seq_LS180_Human1.21090635
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20795835
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.19911072
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19291087
61* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17118075
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15618261
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14421476
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.14149569
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13936259
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13932816
67STAT3_23295773_ChIP-Seq_U87_Human1.12808852
68RXR_22108803_ChIP-Seq_LS180_Human1.11921023
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10360705
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09227035
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07813271
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.07050927
73KDM2B_26808549_Chip-Seq_K562_Human1.06069781
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05459425
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05436631
76TAF15_26573619_Chip-Seq_HEK293_Human1.05256367
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05159845
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05159845
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04720218
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04348818
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03747742
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03580615
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03203272
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03166854
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02853893
86* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02591743
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02197671
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01424841
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01322011
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00550291
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00502782
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.99940301
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99882575
94FUS_26573619_Chip-Seq_HEK293_Human0.99083759
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98802747
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98545835
97* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97936648
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.97101710
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.96510863
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95513598
101TCF4_22108803_ChIP-Seq_LS180_Human0.95243981
102BCAT_22108803_ChIP-Seq_LS180_Human0.95178533
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.94877254
104SALL1_21062744_ChIP-ChIP_HESCs_Human0.94430486
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94030253
106AHR_22903824_ChIP-Seq_MCF-7_Human0.93155751
107TCF4_23295773_ChIP-Seq_U87_Human0.92852298
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.91854412
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90948400
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90678293
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90447876
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.90439840
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89964891
114RUNX2_22187159_ChIP-Seq_PCA_Human0.89526106
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89173381
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88858892
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.88657921
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87384956
119ER_23166858_ChIP-Seq_MCF-7_Human0.87205068
120TP53_16413492_ChIP-PET_HCT116_Human0.87125356
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86578242
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84902131
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83946985
124* TP53_18474530_ChIP-ChIP_U2OS_Human0.83790992
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.83220798
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82813766
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.82441420
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81503024
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80437445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.37756931
2MP0005423_abnormal_somatic_nervous4.83929660
3MP0003880_abnormal_central_pattern4.14168493
4MP0003635_abnormal_synaptic_transmissio3.80563565
5MP0004270_analgesia3.77491934
6MP0000579_abnormal_nail_morphology3.45864732
7MP0009046_muscle_twitch3.08651378
8MP0000566_synostosis3.03275595
9* MP0009745_abnormal_behavioral_response3.01425387
10* MP0002064_seizures2.95116083
11MP0002063_abnormal_learning/memory/cond2.88190450
12MP0004858_abnormal_nervous_system2.84588238
13MP0004885_abnormal_endolymph2.83623099
14MP0001486_abnormal_startle_reflex2.75831648
15MP0001968_abnormal_touch/_nociception2.68745903
16MP0002572_abnormal_emotion/affect_behav2.55543932
17MP0002734_abnormal_mechanical_nocicepti2.49756752
18MP0002272_abnormal_nervous_system2.45681637
19MP0003690_abnormal_glial_cell2.31155846
20MP0005646_abnormal_pituitary_gland2.21371046
21MP0001501_abnormal_sleep_pattern2.16917335
22MP0003329_amyloid_beta_deposits2.12584806
23MP0001440_abnormal_grooming_behavior2.09073096
24MP0002736_abnormal_nociception_after2.00105947
25MP0009780_abnormal_chondrocyte_physiolo1.95335590
26MP0002234_abnormal_pharynx_morphology1.95327282
27MP0008569_lethality_at_weaning1.94600700
28MP0002733_abnormal_thermal_nociception1.91021874
29MP0002067_abnormal_sensory_capabilities1.90747901
30MP0001970_abnormal_pain_threshold1.77398787
31MP0005645_abnormal_hypothalamus_physiol1.74686177
32MP0003633_abnormal_nervous_system1.69053623
33MP0002557_abnormal_social/conspecific_i1.67988999
34MP0000778_abnormal_nervous_system1.64129043
35MP0005167_abnormal_blood-brain_barrier1.58390903
36MP0001502_abnormal_circadian_rhythm1.56081006
37MP0003634_abnormal_glial_cell1.53938410
38MP0004142_abnormal_muscle_tone1.51503312
39MP0002909_abnormal_adrenal_gland1.46750518
40MP0005386_behavior/neurological_phenoty1.44801421
41MP0004924_abnormal_behavior1.44801421
42MP0000955_abnormal_spinal_cord1.43429843
43MP0000762_abnormal_tongue_morphology1.37970087
44MP0001984_abnormal_olfaction1.37674009
45MP0002882_abnormal_neuron_morphology1.36640672
46MP0002184_abnormal_innervation1.36379307
47MP0005551_abnormal_eye_electrophysiolog1.35085710
48MP0002735_abnormal_chemical_nociception1.34567119
49MP0002822_catalepsy1.33555022
50MP0004811_abnormal_neuron_physiology1.33449737
51MP0003631_nervous_system_phenotype1.33125147
52MP0002066_abnormal_motor_capabilities/c1.32960571
53MP0001485_abnormal_pinna_reflex1.31500535
54MP0005360_urolithiasis1.30700449
55MP0003121_genomic_imprinting1.28078123
56MP0006276_abnormal_autonomic_nervous1.27111440
57MP0003195_calcinosis1.26716503
58MP0003075_altered_response_to1.26384774
59MP0003136_yellow_coat_color1.25520324
60MP0003787_abnormal_imprinting1.23329450
61MP0002089_abnormal_postnatal_growth/wei1.17623478
62MP0003122_maternal_imprinting1.17552377
63MP0000920_abnormal_myelination1.16210533
64MP0004043_abnormal_pH_regulation1.15289144
65MP0002229_neurodegeneration1.13717704
66MP0003283_abnormal_digestive_organ1.13305979
67MP0002638_abnormal_pupillary_reflex1.12980585
68MP0002152_abnormal_brain_morphology1.12230938
69MP0001905_abnormal_dopamine_level1.10075339
70MP0002139_abnormal_hepatobiliary_system1.05886538
71MP0000383_abnormal_hair_follicle1.04135466
72MP0002653_abnormal_ependyma_morphology1.03293650
73MP0000604_amyloidosis1.02304116
74MP0006072_abnormal_retinal_apoptosis0.99845236
75MP0001299_abnormal_eye_distance/0.99589062
76MP0010329_abnormal_lipoprotein_level0.98909371
77MP0003632_abnormal_nervous_system0.98559446
78MP0000467_abnormal_esophagus_morphology0.97585424
79MP0005253_abnormal_eye_physiology0.96552754
80MP0008877_abnormal_DNA_methylation0.95169662
81MP0004742_abnormal_vestibular_system0.94876459
82MP0002090_abnormal_vision0.94353331
83MP0008875_abnormal_xenobiotic_pharmacok0.92391868
84MP0000751_myopathy0.91831879
85MP0005187_abnormal_penis_morphology0.91684649
86MP0001177_atelectasis0.91192936
87MP0001963_abnormal_hearing_physiology0.90310554
88MP0005623_abnormal_meninges_morphology0.88221758
89MP0002282_abnormal_trachea_morphology0.87142382
90MP0003137_abnormal_impulse_conducting0.86638426
91MP0003172_abnormal_lysosome_physiology0.85382894
92MP0004215_abnormal_myocardial_fiber0.84895366
93MP0009384_cardiac_valve_regurgitation0.83313891
94MP0008872_abnormal_physiological_respon0.83196242
95MP0003868_abnormal_feces_composition0.82517527
96MP0003879_abnormal_hair_cell0.82469165
97MP0003123_paternal_imprinting0.82138247
98MP0004147_increased_porphyrin_level0.82119527
99MP0001346_abnormal_lacrimal_gland0.81828267
100MP0005409_darkened_coat_color0.81543602
101MP0005085_abnormal_gallbladder_physiolo0.81079925
102MP0005365_abnormal_bile_salt0.80940372
103MP0002069_abnormal_eating/drinking_beha0.79047399
104MP0000631_abnormal_neuroendocrine_gland0.78013626
105MP0002752_abnormal_somatic_nervous0.76202587
106MP0003878_abnormal_ear_physiology0.76166822
107MP0005377_hearing/vestibular/ear_phenot0.76166822
108MP0006292_abnormal_olfactory_placode0.75848529
109MP0010678_abnormal_skin_adnexa0.74475059
110MP0001529_abnormal_vocalization0.72879565
111MP0005535_abnormal_body_temperature0.71861550
112MP0004233_abnormal_muscle_weight0.70980224
113MP0008961_abnormal_basal_metabolism0.70932762
114MP0005171_absent_coat_pigmentation0.70887789
115MP0004085_abnormal_heartbeat0.69684391
116MP0008874_decreased_physiological_sensi0.69509219
117MP0000013_abnormal_adipose_tissue0.68930713
118MP0003315_abnormal_perineum_morphology0.67181546
119MP0005499_abnormal_olfactory_system0.67020283
120MP0005394_taste/olfaction_phenotype0.67020283
121MP0001666_abnormal_nutrient_absorption0.66663358
122MP0002098_abnormal_vibrissa_morphology0.66627604
123MP0003861_abnormal_nervous_system0.66229587
124MP0002254_reproductive_system_inflammat0.65759350
125MP0000569_abnormal_digit_pigmentation0.63706732
126MP0001943_abnormal_respiration0.61894462
127MP0000026_abnormal_inner_ear0.59911562
128MP0004145_abnormal_muscle_electrophysio0.54209187

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.19168551
2Hemiplegia (HP:0002301)5.36717853
3Diplopia (HP:0000651)5.10551072
4Abnormality of binocular vision (HP:0011514)5.10551072
5Myokymia (HP:0002411)5.03537892
6Hemiparesis (HP:0001269)4.98966964
7Focal seizures (HP:0007359)4.67891214
8Aplasia involving bones of the upper limbs (HP:0009823)4.43435077
9Aplasia of the phalanges of the hand (HP:0009802)4.43435077
10Aplasia involving bones of the extremities (HP:0009825)4.43435077
11Supranuclear gaze palsy (HP:0000605)4.43150336
12Visual hallucinations (HP:0002367)4.36608660
13Fragile nails (HP:0001808)4.19856231
14Generalized tonic-clonic seizures (HP:0002069)4.14508794
15Milia (HP:0001056)4.13972223
16Megalencephaly (HP:0001355)4.01157713
17Epileptic encephalopathy (HP:0200134)3.98827967
18Onycholysis (HP:0001806)3.76270609
19Neurofibrillary tangles (HP:0002185)3.69185645
20Action tremor (HP:0002345)3.56996745
21Progressive cerebellar ataxia (HP:0002073)3.48892457
22Postural instability (HP:0002172)3.47673871
23Abnormality of nail color (HP:0100643)3.40481456
24Plantar hyperkeratosis (HP:0007556)3.38774093
25Ankle clonus (HP:0011448)3.38578433
26Absence seizures (HP:0002121)3.33637441
27Abnormal eating behavior (HP:0100738)3.33616851
28Dysdiadochokinesis (HP:0002075)3.30686158
29Tetraplegia (HP:0002445)3.26095852
30Depression (HP:0000716)3.23683249
31Atonic seizures (HP:0010819)3.16174053
32Mutism (HP:0002300)3.08629737
33Esophageal atresia (HP:0002032)3.06051198
34Dialeptic seizures (HP:0011146)3.04603307
35Cerebral inclusion bodies (HP:0100314)3.01190993
36Deep venous thrombosis (HP:0002625)2.96068729
37Febrile seizures (HP:0002373)2.94133165
38Epidermoid cyst (HP:0200040)2.90982739
39Truncal ataxia (HP:0002078)2.80038271
40Status epilepticus (HP:0002133)2.76445511
41Urinary bladder sphincter dysfunction (HP:0002839)2.73574678
42Anxiety (HP:0000739)2.69116693
43Confusion (HP:0001289)2.68379092
44Intention tremor (HP:0002080)2.67881089
45Dysmetria (HP:0001310)2.60333386
46Papilledema (HP:0001085)2.55999442
47Impaired vibration sensation in the lower limbs (HP:0002166)2.49348199
48Broad-based gait (HP:0002136)2.47776345
49Bradykinesia (HP:0002067)2.45943753
50Polyphagia (HP:0002591)2.44926206
51Insomnia (HP:0100785)2.41796242
52Limb dystonia (HP:0002451)2.38543941
53Lower limb muscle weakness (HP:0007340)2.38087104
54Peripheral hypomyelination (HP:0007182)2.37988329
55Clumsiness (HP:0002312)2.34663187
56Increased circulating renin level (HP:0000848)2.33563595
57Gastrointestinal atresia (HP:0002589)2.32119543
58Humeroradial synostosis (HP:0003041)2.30086397
59Synostosis involving the elbow (HP:0003938)2.30086397
60Ventricular fibrillation (HP:0001663)2.30033116
61Prolonged partial thromboplastin time (HP:0003645)2.25254732
62Potter facies (HP:0002009)2.24869692
63Facial shape deformation (HP:0011334)2.24869692
64Spastic gait (HP:0002064)2.24840994
65Poor eye contact (HP:0000817)2.21528224
66Impaired social interactions (HP:0000735)2.17841955
67Abnormal social behavior (HP:0012433)2.17841955
68Abnormality of the axillary hair (HP:0100134)2.14851140
69Abnormality of secondary sexual hair (HP:0009888)2.14851140
70Torticollis (HP:0000473)2.14456391
71Urinary urgency (HP:0000012)2.13365240
72Alopecia of scalp (HP:0002293)2.12019420
73Hyperventilation (HP:0002883)2.10954781
74Excessive salivation (HP:0003781)2.10346907
75Drooling (HP:0002307)2.10346907
76Pheochromocytoma (HP:0002666)2.06430144
77Palmoplantar hyperkeratosis (HP:0000972)2.06117124
78True hermaphroditism (HP:0010459)2.02853461
79Rigidity (HP:0002063)2.00328056
80Palmar hyperkeratosis (HP:0010765)1.99796936
81Progressive inability to walk (HP:0002505)1.99210129
82Atrophic scars (HP:0001075)1.98634020
83Gaze-evoked nystagmus (HP:0000640)1.98049399
84Genetic anticipation (HP:0003743)1.96886189
85Neuronal loss in central nervous system (HP:0002529)1.95513301
86Psychosis (HP:0000709)1.95067099
87Neoplasm of the heart (HP:0100544)1.94097884
88Morphological abnormality of the inner ear (HP:0011390)1.90694731
89Anophthalmia (HP:0000528)1.90443087
90Split foot (HP:0001839)1.90321872
91Alacrima (HP:0000522)1.89890388
92Supernumerary spleens (HP:0009799)1.89839155
93Metabolic alkalosis (HP:0200114)1.88723630
94Generalized myoclonic seizures (HP:0002123)1.88404306
95Gait imbalance (HP:0002141)1.88191023
96Clonus (HP:0002169)1.86349399
97Neuroendocrine neoplasm (HP:0100634)1.86256527
98Agitation (HP:0000713)1.85305324
99Hypoplasia of dental enamel (HP:0006297)1.81377713
100Broad alveolar ridges (HP:0000187)1.79683919
101Oligodontia (HP:0000677)1.79665128
102Focal dystonia (HP:0004373)1.77355095
103Abnormality of the middle phalanges of the toes (HP:0010183)1.75633618
104Thick nail (HP:0001805)1.75547094
105Stereotypic behavior (HP:0000733)1.74687602
106Abnormality of ocular smooth pursuit (HP:0000617)1.73131908
107Impaired smooth pursuit (HP:0007772)1.72917970
108Akinesia (HP:0002304)1.71401524
109Scanning speech (HP:0002168)1.70890235
110Incomplete penetrance (HP:0003829)1.69415516
111Blue irides (HP:0000635)1.69397314
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68719052
113Hypodontia (HP:0000668)1.68474185
114Abnormality of saccadic eye movements (HP:0000570)1.68464331
115Abnormality of the diencephalon (HP:0010662)1.68083422
116Hypoplastic nipples (HP:0002557)1.67392047
117Impaired vibratory sensation (HP:0002495)1.66602796
118Abnormality of cochlea (HP:0000375)1.66078372
119Fibular aplasia (HP:0002990)1.66032043
120Craniofacial dystonia (HP:0012179)1.65058996
121Large for gestational age (HP:0001520)1.64237005
122Bronchomalacia (HP:0002780)1.63993409
123Narrow nasal bridge (HP:0000446)1.63856894
124Abnormality of the corticospinal tract (HP:0002492)1.63698570
125Decreased lacrimation (HP:0000633)1.63643001
126Abnormality of the lower motor neuron (HP:0002366)1.63475867
127Delusions (HP:0000746)1.63327236
128Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.63296699
129EEG with generalized epileptiform discharges (HP:0011198)1.63066573
130Abnormal EKG (HP:0003115)1.62093881
131Joint hemorrhage (HP:0005261)1.61041000
132Epileptiform EEG discharges (HP:0011182)1.60795207
133Postural tremor (HP:0002174)1.60596948
134Oligodactyly (hands) (HP:0001180)1.59767217
135Ankyloglossia (HP:0010296)1.59447291
136Laryngomalacia (HP:0001601)1.58677344
137Bifid scrotum (HP:0000048)1.58626710
138Increased serum pyruvate (HP:0003542)1.58585171
139Hypsarrhythmia (HP:0002521)1.58218847
140Abnormality of the nasal septum (HP:0000419)1.58143283
141Spastic tetraplegia (HP:0002510)1.56433755
142Cutaneous finger syndactyly (HP:0010554)1.55803154
143Pili torti (HP:0003777)1.55219537
144Recurrent corneal erosions (HP:0000495)1.54262999
145Fair hair (HP:0002286)1.52241745
146Nail dystrophy (HP:0008404)1.52225237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.11213356
2NTRK23.67909771
3EPHA43.41197424
4MARK13.29154479
5MAP3K93.09705118
6TNIK2.76826014
7MAP3K42.69074689
8PRKD32.57571963
9MINK12.45094999
10MAPK152.38806074
11PAK62.29547920
12PHKG12.21529480
13PHKG22.21529480
14WNK42.18750166
15MAP2K72.15583676
16NTRK12.09634759
17LMTK22.08775321
18MAPK131.70924310
19CAMKK11.67184105
20STK381.64038862
21MAP2K41.61361486
22CASK1.58956079
23CDK51.47971989
24STK391.46898857
25FES1.43658485
26KSR21.42005937
27TSSK61.41974030
28DAPK21.33169841
29TYRO31.32225018
30PRKCG1.27068147
31UHMK11.26513287
32FRK1.25513780
33SGK4941.23206255
34SGK2231.23206255
35SGK21.22491065
36CAMK1G1.21793520
37LATS21.21350604
38PRKCH1.20817728
39MAP3K121.17100672
40MUSK1.15322736
41GRK51.15269545
42RIPK41.13931320
43SGK31.12557609
44SIK21.06062779
45ALK1.03369161
46TNK21.01481741
47AKT31.00464689
48PAK31.00447253
49PNCK0.98969824
50PLK20.96611383
51MAPKAPK50.95160227
52PINK10.94392633
53KSR10.93616470
54FGFR40.92779806
55FGFR30.91519385
56CAMK2A0.89538272
57CDK150.87567666
58CDK180.84179492
59CDC42BPA0.84014239
60MAPKAPK30.82733830
61BCR0.82677506
62CDK190.81342826
63CAMK10.80552304
64STK110.78631864
65CDK140.77744486
66DYRK20.76670190
67NEK60.75317179
68CDK11A0.75173985
69ERBB20.75054958
70WEE10.74587738
71RAF10.74317112
72TAOK10.74191721
73DYRK1A0.73178873
74CAMK1D0.72688221
75MAP4K20.69725801
76ARAF0.69242325
77ROCK10.68997554
78CSNK1A1L0.68211373
79RET0.68039518
80SGK10.67629662
81CSNK1G30.66422382
82MAPK120.65475763
83EPHB20.64701801
84CAMKK20.63857654
85VRK10.63730045
86RPS6KA30.62839705
87MAP3K130.62116105
88WNK10.61462450
89SCYL20.61359542
90MAP3K20.60763452
91MARK20.60450939
92CAMK2G0.60193383
93PRPF4B0.59629490
94BMX0.59438839
95CSNK1G10.59422675
96BRSK10.58606059
97OXSR10.57892244
98PRKCE0.57412816
99FGFR20.56391997
100BMPR1B0.55488751
101CSNK1G20.55361584
102CAMK2B0.54504966
103ROCK20.54153746
104MAPK100.54133276
105FGFR10.52787373
106FYN0.52021262
107PRKD20.50780009
108PRKCI0.50733490
109PKN10.50534080
110FGR0.49833903
111MAP3K70.49772440
112WNK30.49316311
113PDPK10.48587884
114PIK3CA0.48448750
115MKNK20.48334045
116FER0.47857771
117PRKCZ0.47810121
118PLK30.47789175
119DAPK10.47726565
120RPS6KB10.46927471
121BRAF0.46240682
122DDR20.45359894
123ADRBK20.44987549
124CSNK1D0.44733585
125MET0.44359533
126PDK10.42888485
127PDGFRA0.41938457
128PRKCA0.41411252
129CAMK2D0.41383862
130PRKACG0.41225905
131PRKD10.40536915
132SIK10.40348067
133CSNK1A10.39094093
134PRKACA0.38922658
135PRKAA10.38430268
136ADRBK10.38050668
137GRK10.37604962

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.62379244
2Nicotine addiction_Homo sapiens_hsa050333.54495821
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.42684562
4* GABAergic synapse_Homo sapiens_hsa047272.80156042
5Synaptic vesicle cycle_Homo sapiens_hsa047212.52351450
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39523321
7Glutamatergic synapse_Homo sapiens_hsa047242.35568338
8Salivary secretion_Homo sapiens_hsa049702.27756386
9Circadian entrainment_Homo sapiens_hsa047132.23460768
10Morphine addiction_Homo sapiens_hsa050322.21401267
11Olfactory transduction_Homo sapiens_hsa047402.19453938
12Steroid biosynthesis_Homo sapiens_hsa001002.18051220
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16363394
14Gastric acid secretion_Homo sapiens_hsa049712.12554976
15Insulin secretion_Homo sapiens_hsa049112.11095955
16Long-term potentiation_Homo sapiens_hsa047201.83350582
17Fatty acid biosynthesis_Homo sapiens_hsa000611.82502835
18Amphetamine addiction_Homo sapiens_hsa050311.70610617
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58631828
20Renin secretion_Homo sapiens_hsa049241.57083597
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51805993
22Dopaminergic synapse_Homo sapiens_hsa047281.51588636
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50524769
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50030217
25Taste transduction_Homo sapiens_hsa047421.48329616
26Cocaine addiction_Homo sapiens_hsa050301.48191454
27Bile secretion_Homo sapiens_hsa049761.43923730
28Vitamin B6 metabolism_Homo sapiens_hsa007501.40516707
29Histidine metabolism_Homo sapiens_hsa003401.40307359
30Cholinergic synapse_Homo sapiens_hsa047251.37564312
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36913895
32Calcium signaling pathway_Homo sapiens_hsa040201.32842043
33cAMP signaling pathway_Homo sapiens_hsa040241.28602050
34Complement and coagulation cascades_Homo sapiens_hsa046101.27703868
35Serotonergic synapse_Homo sapiens_hsa047261.26446075
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.24126836
37Dorso-ventral axis formation_Homo sapiens_hsa043201.24111521
38Long-term depression_Homo sapiens_hsa047301.22952679
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15162406
40Oxytocin signaling pathway_Homo sapiens_hsa049211.14654008
41Gap junction_Homo sapiens_hsa045401.14461168
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14138213
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.09728838
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09268414
45Pancreatic secretion_Homo sapiens_hsa049721.09171202
46GnRH signaling pathway_Homo sapiens_hsa049121.08811969
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03635375
48Cardiac muscle contraction_Homo sapiens_hsa042601.03328636
49Arginine and proline metabolism_Homo sapiens_hsa003301.01255494
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97922189
51Melanogenesis_Homo sapiens_hsa049160.97055760
52Thyroid hormone synthesis_Homo sapiens_hsa049180.96278586
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94003447
54ABC transporters_Homo sapiens_hsa020100.88923861
55Estrogen signaling pathway_Homo sapiens_hsa049150.88515346
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88308590
57Axon guidance_Homo sapiens_hsa043600.87256875
58Type II diabetes mellitus_Homo sapiens_hsa049300.86737552
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86210584
60Propanoate metabolism_Homo sapiens_hsa006400.85886849
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85847877
62Mineral absorption_Homo sapiens_hsa049780.85220224
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.84347242
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82715114
65Phototransduction_Homo sapiens_hsa047440.79576537
66Dilated cardiomyopathy_Homo sapiens_hsa054140.78754979
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76650368
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76591081
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75033032
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74824157
71Fat digestion and absorption_Homo sapiens_hsa049750.72550442
72Glioma_Homo sapiens_hsa052140.72446761
73Arginine biosynthesis_Homo sapiens_hsa002200.70285208
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69890364
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68643948
76ErbB signaling pathway_Homo sapiens_hsa040120.67096238
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.66247271
78ECM-receptor interaction_Homo sapiens_hsa045120.64050772
79Collecting duct acid secretion_Homo sapiens_hsa049660.61315676
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60617626
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.58560729
82Hippo signaling pathway_Homo sapiens_hsa043900.57664565
83Fatty acid degradation_Homo sapiens_hsa000710.57126899
84Peroxisome_Homo sapiens_hsa041460.56949444
85Choline metabolism in cancer_Homo sapiens_hsa052310.56322296
86Fatty acid metabolism_Homo sapiens_hsa012120.55670601
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55665317
88Type I diabetes mellitus_Homo sapiens_hsa049400.55663235
89Fatty acid elongation_Homo sapiens_hsa000620.55275107
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54865537
91Vitamin digestion and absorption_Homo sapiens_hsa049770.54088692
92Butanoate metabolism_Homo sapiens_hsa006500.53177142
93beta-Alanine metabolism_Homo sapiens_hsa004100.51257349
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51195158
95MAPK signaling pathway_Homo sapiens_hsa040100.49161437
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48647564
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48530484
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.47182519
99Ras signaling pathway_Homo sapiens_hsa040140.44249360
100Oocyte meiosis_Homo sapiens_hsa041140.43388845
101Prion diseases_Homo sapiens_hsa050200.43307241
102Rap1 signaling pathway_Homo sapiens_hsa040150.43280842
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43103687
104Glucagon signaling pathway_Homo sapiens_hsa049220.42897121
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42238419
106Hedgehog signaling pathway_Homo sapiens_hsa043400.41672563
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.41465654
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40864230
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40667650
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40645627
111Phenylalanine metabolism_Homo sapiens_hsa003600.38414591
112Ovarian steroidogenesis_Homo sapiens_hsa049130.37605265
113Vibrio cholerae infection_Homo sapiens_hsa051100.36439288
114Circadian rhythm_Homo sapiens_hsa047100.35945044
115PPAR signaling pathway_Homo sapiens_hsa033200.34202577
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.34201378
117Wnt signaling pathway_Homo sapiens_hsa043100.33558526
118Endocytosis_Homo sapiens_hsa041440.31399199
119Inositol phosphate metabolism_Homo sapiens_hsa005620.31285518
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29824603
121Basal cell carcinoma_Homo sapiens_hsa052170.29795442
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29738916
123Alcoholism_Homo sapiens_hsa050340.29647268
124Insulin signaling pathway_Homo sapiens_hsa049100.28903738
125Glycerolipid metabolism_Homo sapiens_hsa005610.28137028
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25916425
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.25821922
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23726652
129Ether lipid metabolism_Homo sapiens_hsa005650.23642052

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