SLC5A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)7.77560670
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.49906052
3regulation of guanylate cyclase activity (GO:0031282)7.39257691
4adhesion of symbiont to host cell (GO:0044650)7.26367847
5virion attachment to host cell (GO:0019062)7.26367847
6epoxygenase P450 pathway (GO:0019373)6.52987987
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.21341676
8flavonoid metabolic process (GO:0009812)6.19085356
9fat-soluble vitamin biosynthetic process (GO:0042362)6.13580146
10adhesion of symbiont to host (GO:0044406)6.03973793
11drug catabolic process (GO:0042737)5.89528472
12phospholipid efflux (GO:0033700)5.82309563
13positive regulation of guanylate cyclase activity (GO:0031284)5.72866983
14positive regulation of triglyceride lipase activity (GO:0061365)5.66518963
15positive regulation of lipoprotein lipase activity (GO:0051006)5.66518963
16regulation of cholesterol esterification (GO:0010872)5.60493486
17regulation of triglyceride catabolic process (GO:0010896)5.58098130
18actin filament depolymerization (GO:0030042)5.52421136
19modified amino acid transport (GO:0072337)5.46312555
20fructose metabolic process (GO:0006000)5.38469133
21plasma lipoprotein particle assembly (GO:0034377)5.26218904
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.11018731
233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.11018731
24protein-lipid complex assembly (GO:0065005)5.02870296
25regulation of cellular extravasation (GO:0002691)5.00217373
26cholesterol efflux (GO:0033344)4.87627738
27lipoprotein metabolic process (GO:0042157)4.82537435
28drinking behavior (GO:0042756)4.77140406
29regulation of bile acid biosynthetic process (GO:0070857)4.76569687
30* digestive system process (GO:0022600)4.70015763
31hormone catabolic process (GO:0042447)4.53663967
32regulation of cGMP biosynthetic process (GO:0030826)4.51588472
33receptor guanylyl cyclase signaling pathway (GO:0007168)4.50917481
34glucose 6-phosphate metabolic process (GO:0051156)4.48923485
35purine nucleotide salvage (GO:0032261)4.46393992
36peptide hormone processing (GO:0016486)4.44055352
37very-low-density lipoprotein particle assembly (GO:0034379)4.43701782
38digestion (GO:0007586)4.39528197
39diacylglycerol metabolic process (GO:0046339)4.32450538
40peptide catabolic process (GO:0043171)4.24696644
41bundle of His cell to Purkinje myocyte communication (GO:0086069)4.24554967
42sterol transport (GO:0015918)4.20523814
43cholesterol transport (GO:0030301)4.20523814
44negative regulation of sterol transport (GO:0032372)4.18120786
45negative regulation of cholesterol transport (GO:0032375)4.18120786
46sulfate transmembrane transport (GO:1902358)4.12347088
47cholesterol homeostasis (GO:0042632)4.10794880
48reverse cholesterol transport (GO:0043691)4.10117784
49antibacterial humoral response (GO:0019731)4.08169972
50lipoprotein transport (GO:0042953)4.07971375
51sterol homeostasis (GO:0055092)4.07297079
52positive regulation of fatty acid biosynthetic process (GO:0045723)4.07123712
53UDP-N-acetylglucosamine metabolic process (GO:0006047)4.06466087
54cellular glucuronidation (GO:0052695)4.05867580
55renal system process involved in regulation of blood volume (GO:0001977)4.02870435
56response to hepatocyte growth factor (GO:0035728)4.02808418
57cellular response to hepatocyte growth factor stimulus (GO:0035729)4.02808418
58antimicrobial humoral response (GO:0019730)4.02608741
59uronic acid metabolic process (GO:0006063)4.00746022
60glucuronate metabolic process (GO:0019585)4.00746022
61transepithelial transport (GO:0070633)3.98865680
62bile acid and bile salt transport (GO:0015721)3.93087567
63glycolipid catabolic process (GO:0019377)3.81348718
64glycosphingolipid catabolic process (GO:0046479)3.77341362
65cellular response to nitric oxide (GO:0071732)3.76498324
66sulfur compound transport (GO:0072348)3.76377045
67regulation of vitamin metabolic process (GO:0030656)3.74921887
68vitamin transmembrane transport (GO:0035461)3.74413673
69regulation of cGMP metabolic process (GO:0030823)3.72022816
70thyroid hormone metabolic process (GO:0042403)3.70145412
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.67979307
72bicarbonate transport (GO:0015701)3.64009747
73high-density lipoprotein particle remodeling (GO:0034375)3.62944522
74sulfation (GO:0051923)3.61182376
75positive regulation of pseudopodium assembly (GO:0031274)3.56820438
76response to hydroperoxide (GO:0033194)3.55645167
77nitrogen cycle metabolic process (GO:0071941)3.55071437
78alkaloid metabolic process (GO:0009820)3.51185908
79NADH metabolic process (GO:0006734)3.49540656
80homocysteine metabolic process (GO:0050667)3.49138317
81positive regulation of triglyceride metabolic process (GO:0090208)3.48591979
82vitamin transport (GO:0051180)3.46665497
83drug transport (GO:0015893)3.46062608
84sperm capacitation (GO:0048240)3.46020937
85oligosaccharide catabolic process (GO:0009313)3.45925710
86positive regulation of glycoprotein biosynthetic process (GO:0010560)3.45720052
87protein-lipid complex remodeling (GO:0034368)3.45537848
88macromolecular complex remodeling (GO:0034367)3.45537848
89plasma lipoprotein particle remodeling (GO:0034369)3.45537848
90cGMP-mediated signaling (GO:0019934)3.44292333
91positive regulation of T cell differentiation in thymus (GO:0033089)3.41373505
92regulation of systemic arterial blood pressure by hormone (GO:0001990)3.40646908
93regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.40646908
94endocrine process (GO:0050886)3.40646908
95negative regulation of digestive system process (GO:0060457)3.38617855
96fat-soluble vitamin metabolic process (GO:0006775)3.37864325
97cellular carbohydrate catabolic process (GO:0044275)3.37000851
98response to nitric oxide (GO:0071731)3.36975286
99cellular response to reactive nitrogen species (GO:1902170)3.35673918
100regulation of digestive system process (GO:0044058)3.34484562
101response to phenylpropanoid (GO:0080184)3.34195881
102positive regulation of cGMP biosynthetic process (GO:0030828)3.33923638
103plasma lipoprotein particle organization (GO:0071827)3.32728620
104regulation of lipoprotein metabolic process (GO:0050746)3.31966198
105sulfate transport (GO:0008272)3.31795331
106protein-lipid complex subunit organization (GO:0071825)3.31654608
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.31541947
108polyol transport (GO:0015791)3.31002760
109arginine metabolic process (GO:0006525)3.28938638
110sphingomyelin metabolic process (GO:0006684)3.28552095
111nucleobase catabolic process (GO:0046113)3.27828246
112regulation of penile erection (GO:0060405)3.24286416
113regulation of pseudopodium assembly (GO:0031272)3.22789693
114cGMP biosynthetic process (GO:0006182)3.22125063
115transcytosis (GO:0045056)3.21850726
116negative regulation of thymocyte apoptotic process (GO:0070244)3.21700726
117regulation of cholesterol homeostasis (GO:2000188)3.18623149
118auditory receptor cell differentiation (GO:0042491)3.17606790
119innate immune response in mucosa (GO:0002227)3.17366676
120positive regulation of lipid catabolic process (GO:0050996)3.16789219
121phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15659032
122sexual reproduction (GO:0019953)3.14671351
123exogenous drug catabolic process (GO:0042738)3.14429871
124glutamine family amino acid biosynthetic process (GO:0009084)3.14194512
125hydrogen peroxide catabolic process (GO:0042744)3.12621418
126positive regulation of glycoprotein metabolic process (GO:1903020)3.11868687
127drug metabolic process (GO:0017144)3.11809859
128ceramide catabolic process (GO:0046514)3.11457938
129antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09017189
130glycosylceramide metabolic process (GO:0006677)3.08735022
131vitamin biosynthetic process (GO:0009110)3.07563185
132positive regulation of respiratory burst (GO:0060267)3.05970759
133bile acid metabolic process (GO:0008206)3.03962719
134drug transmembrane transport (GO:0006855)3.02401943
135sphingolipid catabolic process (GO:0030149)3.00531036
136mRNA modification (GO:0016556)3.00246100
137histamine secretion (GO:0001821)2.99134350
138maintenance of gastrointestinal epithelium (GO:0030277)2.98888139
139nucleoside diphosphate biosynthetic process (GO:0009133)2.98816145
140urea metabolic process (GO:0019627)2.98491813
141urea cycle (GO:0000050)2.98491813
142mature B cell differentiation involved in immune response (GO:0002313)2.97745266
143regulation of sterol transport (GO:0032371)2.96404728
144regulation of cholesterol transport (GO:0032374)2.96404728
145glycerol metabolic process (GO:0006071)2.96085010
146regulation of systemic arterial blood pressure (GO:0003073)2.95491995
147cobalamin metabolic process (GO:0009235)2.93829915
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93567164
149phenol-containing compound catabolic process (GO:0019336)2.92577447
150glomerulus development (GO:0032835)2.91741374
151sodium ion homeostasis (GO:0055078)2.89058539
152midgut development (GO:0007494)2.88740587
153leukotriene metabolic process (GO:0006691)2.87433953
154intestinal cholesterol absorption (GO:0030299)12.1017803
155angiotensin maturation (GO:0002003)11.4446287
156* intestinal absorption (GO:0050892)11.1867606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.60574032
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.21647507
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.54682680
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.52162261
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.13702402
6GATA4_25053715_ChIP-Seq_YYC3_Human3.02865903
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91892935
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.79296658
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70491820
10* LXR_22158963_ChIP-Seq_LIVER_Mouse2.66049379
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.65124391
12GATA6_25053715_ChIP-Seq_YYC3_Human2.58025433
13SOX2_20726797_ChIP-Seq_SW620_Human2.53000578
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.50479683
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24463101
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12066748
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.09673199
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.05445428
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82164387
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75899486
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70184336
22PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.68437533
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68274330
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64536320
25KLF5_25053715_ChIP-Seq_YYC3_Human1.64297468
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.64272909
27GATA1_22025678_ChIP-Seq_K562_Human1.61812042
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.59236385
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56069598
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.55868829
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.50311753
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48199945
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47322472
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45991125
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42104910
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41242494
37HNF4A_19822575_ChIP-Seq_HepG2_Human1.41224011
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40072876
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37247206
40GATA2_19941826_ChIP-Seq_K562_Human1.37051949
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35885473
42CLOCK_20551151_ChIP-Seq_293T_Human1.35181299
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33151183
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29831467
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27566591
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25648108
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24669278
48RACK7_27058665_Chip-Seq_MCF-7_Human1.24317449
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.23644474
50RXR_22108803_ChIP-Seq_LS180_Human1.21606435
51ATF3_27146783_Chip-Seq_COLON_Human1.20895557
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.18876823
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17988433
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16625257
55AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16303555
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16240692
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.14223285
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13471481
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13273234
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.07923590
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05861914
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04730125
63CREB1_26743006_Chip-Seq_LNCaP_Human1.02464994
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97570895
65BCAT_22108803_ChIP-Seq_LS180_Human0.97113174
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97104380
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96091906
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94598086
69NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91775583
70NANOG_20526341_ChIP-Seq_ESCs_Human0.90287780
71SMAD3_21741376_ChIP-Seq_HESCs_Human0.90157766
72* TP63_23658742_ChIP-Seq_EP156T_Human0.89560382
73EGR1_19032775_ChIP-ChIP_M12_Human0.89424594
74SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89128831
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88970487
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88952282
77ZNF263_19887448_ChIP-Seq_K562_Human0.88316215
78TP53_16413492_ChIP-PET_HCT116_Human0.88228832
79VDR_22108803_ChIP-Seq_LS180_Human0.87751183
80IRF8_21731497_ChIP-ChIP_J774_Mouse0.87552575
81CEBPB_22108803_ChIP-Seq_LS180_Human0.87134866
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85974022
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85782153
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85782153
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85258496
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85094914
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84197859
88SA1_27219007_Chip-Seq_Bcells_Human0.84162767
89GATA3_24758297_ChIP-Seq_MCF-7_Human0.84112948
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83624538
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83215486
92* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82476526
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82060633
94DROSHA_22980978_ChIP-Seq_HELA_Human0.81954709
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81880920
96* BCOR_27268052_Chip-Seq_Bcells_Human0.81867385
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81611607
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81579051
99AR_21909140_ChIP-Seq_LNCAP_Human0.81434068
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80757148
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80748304
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.79907675
103* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79199209
104VDR_24787735_ChIP-Seq_THP-1_Human0.79154355
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79047594
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78759043
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78583421
108GATA1_19941826_ChIP-Seq_K562_Human0.78313422
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78279035
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78226280
111* BCL6_27268052_Chip-Seq_Bcells_Human0.77944419
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77519267
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76985809
114CDX2_22108803_ChIP-Seq_LS180_Human0.76704831
115HNFA_21074721_ChIP-Seq_CACO-2_Human0.76493104
116LXR_22292898_ChIP-Seq_THP-1_Human0.76440167
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.76420228
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.76420228
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75787548
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75613323
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.75610076
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.75366986
123CJUN_26792858_Chip-Seq_BT549_Human0.75200117
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75012719
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74298065
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72793067
127* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72554012
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72471369
129* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.71277898
130FOXA1_21572438_ChIP-Seq_LNCaP_Human0.71253040
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69217982
132TP63_22573176_ChIP-Seq_HFKS_Human0.68976787
133* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.68859956
134CTCF_27219007_Chip-Seq_Bcells_Human0.68284319
135SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67861075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption5.97152978
2MP0003183_abnormal_peptide_metabolism4.28748512
3MP0009840_abnormal_foam_cell4.20954625
4MP0002139_abnormal_hepatobiliary_system3.85420713
5MP0010234_abnormal_vibrissa_follicle3.85164871
6MP0003252_abnormal_bile_duct3.64603298
7MP0004264_abnormal_extraembryonic_tissu3.19909898
8MP0005085_abnormal_gallbladder_physiolo3.17632134
9MP0008875_abnormal_xenobiotic_pharmacok2.99558978
10MP0000462_abnormal_digestive_system2.89174619
11MP0010329_abnormal_lipoprotein_level2.70404224
12MP0003866_abnormal_defecation2.43739467
13MP0005409_darkened_coat_color2.33591824
14MP0004147_increased_porphyrin_level2.31470580
15MP0004019_abnormal_vitamin_homeostasis2.18970361
16MP0004043_abnormal_pH_regulation2.14935412
17MP0005360_urolithiasis10.2804335
18MP0005670_abnormal_white_adipose1.97034970
19MP0003300_gastrointestinal_ulcer1.96549123
20MP0005365_abnormal_bile_salt1.94740550
21MP0009697_abnormal_copulation1.93187942
22MP0005084_abnormal_gallbladder_morpholo1.89843463
23MP0002822_catalepsy1.72454351
24MP0000538_abnormal_urinary_bladder1.70165011
25MP0003868_abnormal_feces_composition1.67519228
26MP0000537_abnormal_urethra_morphology1.65243406
27MP0003878_abnormal_ear_physiology1.63059837
28MP0005377_hearing/vestibular/ear_phenot1.63059837
29MP0001664_abnormal_digestion1.60235601
30MP0005381_digestive/alimentary_phenotyp1.58999291
31MP0001663_abnormal_digestive_system1.58630328
32MP0002254_reproductive_system_inflammat1.53025126
33MP0003705_abnormal_hypodermis_morpholog1.51787253
34MP0002796_impaired_skin_barrier1.46575172
35MP0010352_gastrointestinal_tract_polyps1.45818553
36MP0001873_stomach_inflammation1.45350089
37MP0010155_abnormal_intestine_physiology1.44990840
38MP0001188_hyperpigmentation1.41354702
39MP0005448_abnormal_energy_balance1.41038053
40MP0002089_abnormal_postnatal_growth/wei1.36975216
41MP0000477_abnormal_intestine_morphology1.35994391
42MP0005332_abnormal_amino_acid1.32679259
43MP0004858_abnormal_nervous_system1.26685920
44MP0003191_abnormal_cellular_cholesterol1.26628655
45MP0001501_abnormal_sleep_pattern1.25788305
46MP0004215_abnormal_myocardial_fiber1.24209076
47MP0004782_abnormal_surfactant_physiolog1.21755661
48MP0009643_abnormal_urine_homeostasis1.18102842
49MP0006054_spinal_hemorrhage1.17694283
50MP0009780_abnormal_chondrocyte_physiolo1.14015821
51MP0000490_abnormal_crypts_of1.13918208
52MP0003806_abnormal_nucleotide_metabolis1.12458824
53MP0009379_abnormal_foot_pigmentation1.10407978
54MP0002118_abnormal_lipid_homeostasis1.06794662
55MP0005535_abnormal_body_temperature1.05020219
56MP0004484_altered_response_of1.01892671
57MP0000609_abnormal_liver_physiology0.99625449
58MP0002876_abnormal_thyroid_physiology0.94800141
59MP0008775_abnormal_heart_ventricle0.91877289
60MP0005501_abnormal_skin_physiology0.90648243
61MP0005451_abnormal_body_composition0.90416197
62MP0000467_abnormal_esophagus_morphology0.89421005
63MP0003718_maternal_effect0.88840012
64MP0004947_skin_inflammation0.86644994
65MP0005266_abnormal_metabolism0.86201004
66MP0010678_abnormal_skin_adnexa0.83493690
67MP0004270_analgesia0.82845891
68MP0001765_abnormal_ion_homeostasis0.80960943
69MP0001849_ear_inflammation0.79507298
70MP0001485_abnormal_pinna_reflex0.79319404
71MP0008872_abnormal_physiological_respon0.78418424
72MP0001845_abnormal_inflammatory_respons0.78004634
73MP0002098_abnormal_vibrissa_morphology0.77756080
74MP0002138_abnormal_hepatobiliary_system0.76877527
75MP0005636_abnormal_mineral_homeostasis0.76598272
76MP0005165_increased_susceptibility_to0.74001401
77MP0005367_renal/urinary_system_phenotyp0.73948623
78MP0000516_abnormal_urinary_system0.73948623
79MP0009053_abnormal_anal_canal0.72368703
80MP0002136_abnormal_kidney_physiology0.72287916
81MP0005330_cardiomyopathy0.72270690
82MP0005167_abnormal_blood-brain_barrier0.72157715
83MP0000465_gastrointestinal_hemorrhage0.70932558
84MP0002166_altered_tumor_susceptibility0.70755645
85MP0005666_abnormal_adipose_tissue0.70744235
86MP0005319_abnormal_enzyme/_coenzyme0.70002363
87MP0003453_abnormal_keratinocyte_physiol0.69528686
88MP0003283_abnormal_digestive_organ0.68332200
89MP0000566_synostosis0.67238033
90MP0009384_cardiac_valve_regurgitation0.66114336
91MP0008004_abnormal_stomach_pH0.65899593
92MP0008469_abnormal_protein_level0.62197174
93MP0009785_altered_susceptibility_to0.59983753
94MP0005385_cardiovascular_system_phenoty0.59499161
95MP0001544_abnormal_cardiovascular_syste0.59499161
96MP0002896_abnormal_bone_mineralization0.58701472
97MP0000249_abnormal_blood_vessel0.58132408
98MP0001764_abnormal_homeostasis0.56677921
99MP0001216_abnormal_epidermal_layer0.56339941
100MP0003953_abnormal_hormone_level0.55923044
101MP0005584_abnormal_enzyme/coenzyme_acti0.54786021
102MP0003950_abnormal_plasma_membrane0.54547785
103MP0009642_abnormal_blood_homeostasis0.54196432
104MP0005174_abnormal_tail_pigmentation0.54093943
105MP0003724_increased_susceptibility_to0.54045028
106MP0005334_abnormal_fat_pad0.52374445
107MP0005376_homeostasis/metabolism_phenot0.52136854
108MP0004085_abnormal_heartbeat0.51932292
109MP0003329_amyloid_beta_deposits0.51442208
110MP0005166_decreased_susceptibility_to0.51403237
111MP0002396_abnormal_hematopoietic_system0.51348605
112MP0003638_abnormal_response/metabolism_0.51121263
113MP0002972_abnormal_cardiac_muscle0.50515538
114MP0009115_abnormal_fat_cell0.50426466
115MP0001881_abnormal_mammary_gland0.48024649
116MP0006138_congestive_heart_failure0.47745338
117MP0002277_abnormal_respiratory_mucosa0.47521532
118MP0009765_abnormal_xenobiotic_induced0.47327933
119MP0003879_abnormal_hair_cell0.47235350
120MP0004510_myositis0.47125799
121MP0000604_amyloidosis0.46088459
122MP0001191_abnormal_skin_condition0.45205750
123MP0000427_abnormal_hair_cycle0.43119414
124MP0000579_abnormal_nail_morphology0.41829348
125MP0000678_abnormal_parathyroid_gland0.41518867
126MP0003941_abnormal_skin_development0.40880593
127MP0005310_abnormal_salivary_gland0.39561459
128MP0000230_abnormal_systemic_arterial0.38871892
129MP0001756_abnormal_urination0.38836800
130MP0000377_abnormal_hair_follicle0.37703911
131MP0000613_abnormal_salivary_gland0.37026718
132MP0002971_abnormal_brown_adipose0.36046927
133MP0000470_abnormal_stomach_morphology0.35993258
134MP0003315_abnormal_perineum_morphology0.33785190
135MP0008873_increased_physiological_sensi0.33742967
136MP0002078_abnormal_glucose_homeostasis0.33136060

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.92845082
2Abnormality of glutamine family amino acid metabolism (HP:0010902)8.02395742
3Acanthocytosis (HP:0001927)7.28680289
4Hypobetalipoproteinemia (HP:0003563)7.10153859
5Autoimmune thrombocytopenia (HP:0001973)6.68251700
6Hydroxyprolinuria (HP:0003080)6.03605336
7Abnormality of proline metabolism (HP:0010907)6.03605336
8Malnutrition (HP:0004395)5.63149056
9Autoimmune hemolytic anemia (HP:0001890)5.31267123
10Conjugated hyperbilirubinemia (HP:0002908)5.23046370
11Right ventricular cardiomyopathy (HP:0011663)4.92091945
12Cupped ribs (HP:0000887)4.85952092
13Pigmentary retinal degeneration (HP:0001146)4.46354139
14Increased IgE level (HP:0003212)4.36533067
15Poikilocytosis (HP:0004447)4.21704638
16Mesangial abnormality (HP:0001966)4.18502180
17Fat malabsorption (HP:0002630)4.17455349
18Hyperglycinuria (HP:0003108)4.05920835
19Hypolipoproteinemia (HP:0010981)4.05328377
20Systemic lupus erythematosus (HP:0002725)3.84490988
21Widely patent fontanelles and sutures (HP:0004492)3.73168766
22B lymphocytopenia (HP:0010976)3.60170511
23Abnormality of B cell number (HP:0010975)3.60170511
24Decreased circulating renin level (HP:0003351)3.53314454
25Potter facies (HP:0002009)3.34791911
26Facial shape deformation (HP:0011334)3.34791911
27* Chronic diarrhea (HP:0002028)3.20552519
28Severe combined immunodeficiency (HP:0004430)3.19018910
29Gastrointestinal dysmotility (HP:0002579)3.17823018
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.13107854
31Xanthomatosis (HP:0000991)3.12930664
32Increased purine levels (HP:0004368)3.08391847
33Hyperuricemia (HP:0002149)3.08391847
34Rectal prolapse (HP:0002035)2.98076539
35Steatorrhea (HP:0002570)2.96193490
36Thyroiditis (HP:0100646)2.94937262
37Nephrolithiasis (HP:0000787)2.91151729
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.89607439
39Combined immunodeficiency (HP:0005387)2.87458664
40Abnormality of purine metabolism (HP:0004352)2.85193845
41Alkalosis (HP:0001948)2.85059175
42Posterior subcapsular cataract (HP:0007787)2.82335187
43Abnormality of serine family amino acid metabolism (HP:0010894)2.81479682
44Abnormality of glycine metabolism (HP:0010895)2.81479682
45Reticulocytosis (HP:0001923)2.76073442
46Abnormality of renin-angiotensin system (HP:0000847)2.75102717
47Increased mean platelet volume (HP:0011877)2.74188960
48Hypercholesterolemia (HP:0003124)2.74003419
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69773013
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.66084786
51Abnormality of chloride homeostasis (HP:0011422)2.61715078
52Ventricular fibrillation (HP:0001663)2.55093652
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.53607603
54Hypotension (HP:0002615)2.50444760
55Sudden death (HP:0001699)2.50437062
56Intrahepatic cholestasis (HP:0001406)2.49729277
57Abnormality of vitamin B metabolism (HP:0004340)2.46640182
58Hyperactive renin-angiotensin system (HP:0000841)2.44820421
59Enlarged epiphyses (HP:0010580)2.42272287
60Hyperphosphaturia (HP:0003109)2.41678912
61Abnormal biliary tract morphology (HP:0012440)2.40353379
62Eczematoid dermatitis (HP:0000976)2.37318199
63Hyperphosphatemia (HP:0002905)2.37236411
64Abnormal platelet volume (HP:0011876)2.37102913
65Wide cranial sutures (HP:0010537)2.36840584
66Focal segmental glomerulosclerosis (HP:0000097)2.36337465
67Gout (HP:0001997)2.36168636
68Polycythemia (HP:0001901)2.34062117
69Epidermoid cyst (HP:0200040)2.33651177
70* Dehydration (HP:0001944)2.32684934
71Bundle branch block (HP:0011710)2.31486060
72Goiter (HP:0000853)2.27829303
73Abnormality of the gastric mucosa (HP:0004295)2.27309812
74Villous atrophy (HP:0011473)2.26382019
75Abnormality of small intestinal villus morphology (HP:0011472)2.26382019
76Woolly hair (HP:0002224)2.24307161
77Palpitations (HP:0001962)2.20267103
78Congenital sensorineural hearing impairment (HP:0008527)2.20125217
79Abnormality of nucleobase metabolism (HP:0010932)2.19544043
80Abnormality of vitamin metabolism (HP:0100508)2.18508030
81Mildly elevated creatine phosphokinase (HP:0008180)2.18150040
82Hemorrhage of the eye (HP:0011885)2.16333410
83* Abdominal distention (HP:0003270)2.15258254
84Delayed epiphyseal ossification (HP:0002663)2.12765964
85Protuberant abdomen (HP:0001538)2.12483373
86Abnormality of magnesium homeostasis (HP:0004921)2.12157707
87Abnormality of the costochondral junction (HP:0000919)2.10724667
88Subcapsular cataract (HP:0000523)2.10027921
89Dicarboxylic aciduria (HP:0003215)2.09652568
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09652568
91Confusion (HP:0001289)2.06444995
92Abnormal urine phosphate concentration (HP:0012599)2.05303943
93Flat acetabular roof (HP:0003180)2.04628444
94Ventricular tachycardia (HP:0004756)2.04404078
95Abnormality of eosinophils (HP:0001879)2.03469610
96Pancreatitis (HP:0001733)2.02776141
97Glomerulonephritis (HP:0000099)1.97175835
98Proximal tubulopathy (HP:0000114)1.96821374
99Pustule (HP:0200039)1.96236774
100Nausea (HP:0002018)1.95998564
101Pili torti (HP:0003777)1.95987251
102Progressive sensorineural hearing impairment (HP:0000408)1.95971320
103Eosinophilia (HP:0001880)1.95759643
104Myopathic facies (HP:0002058)1.93971770
105Hyperammonemia (HP:0001987)1.93140076
106Complement deficiency (HP:0004431)1.93047972
107Hypoproteinemia (HP:0003075)1.92517936
108Syncope (HP:0001279)1.91890056
109Cerebral palsy (HP:0100021)1.91762062
110Skin nodule (HP:0200036)1.90339249
111Abnormality of complement system (HP:0005339)1.89537914
112Male infertility (HP:0003251)1.89204589
113Cheilitis (HP:0100825)1.87537237
114Ventricular arrhythmia (HP:0004308)1.86924710
115Gingivitis (HP:0000230)1.86753648
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86659547
117Hyperparathyroidism (HP:0000843)1.86332236
118Milia (HP:0001056)1.86258503
119Megaloblastic anemia (HP:0001889)1.86046422
120Growth hormone excess (HP:0000845)1.85496155
121Renal tubular acidosis (HP:0001947)1.85105046
122Hyperbilirubinemia (HP:0002904)1.84930406
123Abnormal gallbladder physiology (HP:0012438)1.83666426
124Cholecystitis (HP:0001082)1.83666426
125Irritability (HP:0000737)1.82415071
126Thin bony cortex (HP:0002753)1.82211271
127Nephritis (HP:0000123)1.79707728
128Abnormal albumin level (HP:0012116)1.78263644
129Hypoalbuminemia (HP:0003073)1.78263644
130Glomerulosclerosis (HP:0000096)1.77350128
131Impaired platelet aggregation (HP:0003540)1.76971946
132Abnormal platelet function (HP:0011869)1.76971946
133Late onset (HP:0003584)1.76367681
134Exocrine pancreatic insufficiency (HP:0001738)1.75888853
135Metabolic alkalosis (HP:0200114)1.73452827
136* Metabolic acidosis (HP:0001942)1.73440244
137Hypophosphatemia (HP:0002148)1.72242802
138Abnormality of the 1st metacarpal (HP:0010009)1.70292933
139Symptomatic seizures (HP:0011145)1.68707303
140* Glycosuria (HP:0003076)1.67583739
141* Abnormality of urine glucose concentration (HP:0011016)1.67583739
142Sensorimotor neuropathy (HP:0007141)1.67030974
143Granulocytopenia (HP:0001913)1.65651344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.56379372
2FRK7.55213849
3LMTK26.48118583
4MST45.35114877
5MST1R4.19084820
6PRKG23.32648295
7GRK63.00923034
8NME12.83794178
9AKT32.66276191
10EPHA22.41603605
11RIPK12.39039291
12EPHA32.26441084
13MAP3K102.22167409
14MAP3K22.12629675
15PTK61.99432491
16NUAK11.90496124
17ERN11.78809211
18MAP2K21.75166386
19MET1.53251938
20STK241.52133296
21EPHB21.51179355
22FGFR31.42046806
23MAP3K121.37486138
24TESK21.37392431
25TESK11.29465856
26NLK1.28253105
27STK101.19372251
28EPHA41.17170558
29LATS11.10667212
30CDC42BPA1.05353030
31DDR20.98496213
32TAOK10.93033455
33BMX0.91686387
34FER0.89407494
35PTK20.86209407
36PRKCI0.86196362
37IRAK10.86006887
38MAP3K70.85506978
39PDK20.83917328
40EPHB10.83506997
41MAP2K60.81971753
42MATK0.81026369
43STK390.78619768
44KSR20.78355451
45MAP3K110.76815244
46RIPK40.76623312
47TTK0.75254646
48OXSR10.75025414
49PRPF4B0.74663232
50ERBB20.74418583
51MAP3K80.73842948
52MYLK0.72727913
53PRKAA20.72714693
54CASK0.71267486
55SCYL20.71244683
56TAOK30.68338133
57PBK0.63951390
58PIK3CA0.61401425
59MAP3K30.60288222
60OBSCN0.60227345
61PAK40.60140914
62WNK40.54082551
63JAK10.53840314
64TBK10.53166135
65MAPK110.53111525
66PRKCZ0.50963194
67MAP3K10.49184149
68MAP2K10.48974204
69ICK0.48920712
70PDK40.48841423
71PDK30.48841423
72MAP3K90.48287661
73PDPK10.47768591
74PRKAA10.47415743
75DYRK1B0.47147931
76PIM20.46808617
77RET0.46031876
78GRK10.44520638
79CAMK2G0.44198755
80LRRK20.42082113
81PAK30.41554742
82YES10.40113136
83CAMK2B0.39597225
84TYK20.37849351
85PIM10.37277140
86BMPR20.35595490
87PRKCE0.35484255
88CDK60.34515262
89CAMK2A0.33863208
90DAPK20.33002179
91CSK0.32081070
92STK30.31595949
93JAK20.30355073
94PDK10.30354663
95ERBB40.30322053
96PRKACA0.30118640
97LIMK10.29852958
98PRKCA0.27192112
99ROCK10.26263613
100TGFBR20.25024080
101PRKD10.24148012
102SRC0.23976178
103IKBKE0.23288972
104ZAP700.23287698
105PDGFRA0.23088772
106MAPK70.22887589
107CSNK1A10.22665407
108ADRBK20.22509006
109PRKACG0.21726109
110IGF1R0.21640294
111TNIK0.20397719
112AKT20.19871202
113MAP3K50.19591385
114DMPK0.19591323
115IRAK30.18789938
116MAPKAPK20.18683742
117MELK0.18457690
118MAPKAPK30.18454694
119MAP3K60.18442861
120CDK120.18386122
121PKN20.17978450
122ITK0.17884731
123GSK3A0.17307684
124FGR0.17245725
125PRKCQ0.17152678
126FYN0.17149894
127INSRR0.16700919
128NEK10.14647918
129PRKCD0.14322674
130TYRO30.14290674
131MAP4K10.12936198
132FGFR40.12878022
133AURKB0.12471015
134PAK20.10854676
135STK110.09379484
136PAK10.09320782
137CAMK2D0.08576015

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.11028991
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.69854581
3Renin-angiotensin system_Homo sapiens_hsa046144.60995388
4Vitamin digestion and absorption_Homo sapiens_hsa049774.29742827
5* Mineral absorption_Homo sapiens_hsa049783.70025003
6Caffeine metabolism_Homo sapiens_hsa002322.96680245
7Galactose metabolism_Homo sapiens_hsa000522.86814599
8Starch and sucrose metabolism_Homo sapiens_hsa005002.80075713
9Protein digestion and absorption_Homo sapiens_hsa049742.48209671
10Sulfur metabolism_Homo sapiens_hsa009202.25995497
11* Carbohydrate digestion and absorption_Homo sapiens_hsa049732.23908227
12Folate biosynthesis_Homo sapiens_hsa007902.16257380
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.15092258
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13313831
15Fructose and mannose metabolism_Homo sapiens_hsa000511.88313863
16* Bile secretion_Homo sapiens_hsa049761.76225945
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72144349
18Histidine metabolism_Homo sapiens_hsa003401.54285198
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.50393516
20PPAR signaling pathway_Homo sapiens_hsa033201.41082831
21Glutathione metabolism_Homo sapiens_hsa004801.40527949
22Nitrogen metabolism_Homo sapiens_hsa009101.37469134
23Glycerolipid metabolism_Homo sapiens_hsa005611.34932447
24Arginine biosynthesis_Homo sapiens_hsa002201.31437528
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30778162
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27287656
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24466756
28Sphingolipid metabolism_Homo sapiens_hsa006001.19832086
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15359916
30Tryptophan metabolism_Homo sapiens_hsa003801.14982929
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14500872
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12978449
33Fatty acid degradation_Homo sapiens_hsa000711.09325697
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09134194
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07402074
36Asthma_Homo sapiens_hsa053101.02111511
37ABC transporters_Homo sapiens_hsa020100.99719218
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99497944
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91300759
40Arginine and proline metabolism_Homo sapiens_hsa003300.85868043
41Thyroid hormone synthesis_Homo sapiens_hsa049180.85012134
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77610539
43Pyruvate metabolism_Homo sapiens_hsa006200.73097258
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71351794
45Carbon metabolism_Homo sapiens_hsa012000.69645697
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.68990876
47Allograft rejection_Homo sapiens_hsa053300.67986987
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67079948
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.64052597
50Autoimmune thyroid disease_Homo sapiens_hsa053200.62682656
51Pentose phosphate pathway_Homo sapiens_hsa000300.60359490
52Fatty acid biosynthesis_Homo sapiens_hsa000610.58882819
53Graft-versus-host disease_Homo sapiens_hsa053320.58122311
54Staphylococcus aureus infection_Homo sapiens_hsa051500.57467531
55Chemical carcinogenesis_Homo sapiens_hsa052040.56341638
56Type I diabetes mellitus_Homo sapiens_hsa049400.56107123
57Pancreatic secretion_Homo sapiens_hsa049720.55911712
58Tight junction_Homo sapiens_hsa045300.54876706
59Linoleic acid metabolism_Homo sapiens_hsa005910.53560072
60beta-Alanine metabolism_Homo sapiens_hsa004100.53403948
61Arachidonic acid metabolism_Homo sapiens_hsa005900.51586639
62Retinol metabolism_Homo sapiens_hsa008300.50352836
63Type II diabetes mellitus_Homo sapiens_hsa049300.49098227
64Fatty acid metabolism_Homo sapiens_hsa012120.44799584
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44794692
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42170901
67Gastric acid secretion_Homo sapiens_hsa049710.40866985
68Tyrosine metabolism_Homo sapiens_hsa003500.40741267
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40550161
70Peroxisome_Homo sapiens_hsa041460.40268192
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.39774658
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37575055
73Biosynthesis of amino acids_Homo sapiens_hsa012300.36786798
74Butanoate metabolism_Homo sapiens_hsa006500.34781392
75Selenocompound metabolism_Homo sapiens_hsa004500.33764603
76Cocaine addiction_Homo sapiens_hsa050300.33727467
77Glucagon signaling pathway_Homo sapiens_hsa049220.33074930
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31630908
79Other glycan degradation_Homo sapiens_hsa005110.31192389
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30767096
81Ether lipid metabolism_Homo sapiens_hsa005650.30227810
82Steroid biosynthesis_Homo sapiens_hsa001000.28692669
83Metabolic pathways_Homo sapiens_hsa011000.25278438
84Hepatitis C_Homo sapiens_hsa051600.23685093
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.23477277
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.23161883
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.23119614
88Bladder cancer_Homo sapiens_hsa052190.23032511
89Amphetamine addiction_Homo sapiens_hsa050310.21967846
90Antigen processing and presentation_Homo sapiens_hsa046120.21284577
91African trypanosomiasis_Homo sapiens_hsa051430.20988880
92Lysine degradation_Homo sapiens_hsa003100.20803492
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20365775
94Fatty acid elongation_Homo sapiens_hsa000620.20155965
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.19548805
96Salivary secretion_Homo sapiens_hsa049700.18038097
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17811518
98Viral myocarditis_Homo sapiens_hsa054160.17763574
99Salmonella infection_Homo sapiens_hsa051320.17600091
100Thyroid cancer_Homo sapiens_hsa052160.17224923
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17081147
102Adherens junction_Homo sapiens_hsa045200.16332167
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.15250100
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15105408
105Serotonergic synapse_Homo sapiens_hsa047260.14918699
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14300236
107Ovarian steroidogenesis_Homo sapiens_hsa049130.14009836
108Leishmaniasis_Homo sapiens_hsa051400.13480823
109GnRH signaling pathway_Homo sapiens_hsa049120.12930495
110Vibrio cholerae infection_Homo sapiens_hsa051100.12575939
111Renin secretion_Homo sapiens_hsa049240.12469373
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12177740
113Insulin secretion_Homo sapiens_hsa049110.11107133
114Pertussis_Homo sapiens_hsa051330.11105641
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.10034443
116AMPK signaling pathway_Homo sapiens_hsa041520.09747765
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.09700266
118Propanoate metabolism_Homo sapiens_hsa006400.09539983
119Phenylalanine metabolism_Homo sapiens_hsa003600.09070906
120Insulin resistance_Homo sapiens_hsa049310.09045345
121Inositol phosphate metabolism_Homo sapiens_hsa005620.07160959
122Sulfur relay system_Homo sapiens_hsa041220.06970342
123Choline metabolism in cancer_Homo sapiens_hsa052310.05635839
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.04329103
125Hematopoietic cell lineage_Homo sapiens_hsa046400.01269808
126Long-term depression_Homo sapiens_hsa047300.00878799
127VEGF signaling pathway_Homo sapiens_hsa043700.00626898
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0023060

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