SLC4A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.89875422
2Golgi transport vesicle coating (GO:0048200)6.89875422
3paraxial mesoderm development (GO:0048339)5.68671690
4COPII vesicle coating (GO:0048208)4.63029160
5pore complex assembly (GO:0046931)4.56524906
6endocrine pancreas development (GO:0031018)4.41579194
7peptide hormone processing (GO:0016486)4.30623473
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.14580601
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.03439636
10intestinal absorption (GO:0050892)3.97361090
11embryonic foregut morphogenesis (GO:0048617)3.92744879
12sequestering of metal ion (GO:0051238)3.86180558
13intestinal epithelial cell development (GO:0060576)3.84530839
14vesicle coating (GO:0006901)3.81164185
15ER overload response (GO:0006983)3.80156073
16pre-miRNA processing (GO:0031054)3.72087298
17activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.67710115
18regulation of type B pancreatic cell apoptotic process (GO:2000674)3.62203148
19positive regulation of nuclease activity (GO:0032075)3.52728715
20negative regulation of DNA repair (GO:0045738)3.49847209
21regulation of meiosis I (GO:0060631)3.46331246
22regulation of gene silencing by RNA (GO:0060966)3.43279253
23regulation of posttranscriptional gene silencing (GO:0060147)3.43279253
24regulation of gene silencing by miRNA (GO:0060964)3.43279253
25glandular epithelial cell differentiation (GO:0002067)3.40686157
26cell adhesion mediated by integrin (GO:0033627)3.36662828
27protein maturation by protein folding (GO:0022417)3.34973580
28regulation of centriole replication (GO:0046599)3.33713354
29UDP-N-acetylglucosamine metabolic process (GO:0006047)3.33495309
30heterochromatin organization (GO:0070828)3.30000308
31negative regulation of bone resorption (GO:0045779)3.28241313
32regulation of nuclease activity (GO:0032069)3.28181462
33histone H3-K9 demethylation (GO:0033169)3.27413329
34cytoplasmic mRNA processing body assembly (GO:0033962)3.27124039
35columnar/cuboidal epithelial cell development (GO:0002066)3.25118469
36photoreceptor cell development (GO:0042461)3.21991603
37photoreceptor cell maintenance (GO:0045494)3.21667214
38eye photoreceptor cell development (GO:0042462)3.18802871
39endoplasmic reticulum unfolded protein response (GO:0030968)3.18232451
40hemidesmosome assembly (GO:0031581)3.16377904
41protein retention in ER lumen (GO:0006621)3.15840633
42exocrine pancreas development (GO:0031017)3.14855357
43histone H3-K36 demethylation (GO:0070544)3.13449781
44negative regulation of fibroblast apoptotic process (GO:2000270)3.13412857
45type B pancreatic cell development (GO:0003323)3.12901373
46negative regulation of translation, ncRNA-mediated (GO:0040033)3.12697519
47regulation of translation, ncRNA-mediated (GO:0045974)3.12697519
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.12697519
49artery development (GO:0060840)3.11393867
50cellular response to unfolded protein (GO:0034620)3.08220779
51regulation of rhodopsin mediated signaling pathway (GO:0022400)3.06014887
52regulation of histone H3-K9 methylation (GO:0051570)3.04140087
53protein localization to kinetochore (GO:0034501)3.03272523
54protein targeting to Golgi (GO:0000042)3.02238619
55intra-Golgi vesicle-mediated transport (GO:0006891)3.01268450
56ER-nucleus signaling pathway (GO:0006984)3.01134938
57protein localization to chromosome, centromeric region (GO:0071459)2.95098625
58insulin secretion (GO:0030073)2.94632087
59histone-serine phosphorylation (GO:0035404)2.94416513
60mitotic sister chromatid cohesion (GO:0007064)2.94161962
61regulation of DNA methylation (GO:0044030)2.94037597
62glandular epithelial cell development (GO:0002068)2.93716619
63microtubule anchoring (GO:0034453)2.93654508
64positive regulation of hormone biosynthetic process (GO:0046886)2.93429676
65pericardium development (GO:0060039)2.92774947
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92230755
67rhodopsin mediated signaling pathway (GO:0016056)2.90299597
68chromatin remodeling at centromere (GO:0031055)2.89572915
69retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89560793
70neural tube formation (GO:0001841)2.88742252
71retinal cone cell development (GO:0046549)2.87646332
72cellular response to topologically incorrect protein (GO:0035967)2.85356292
73ectoderm development (GO:0007398)2.82191223
74intestinal cholesterol absorption (GO:0030299)2.81738042
75metaphase plate congression (GO:0051310)2.81644991
76regulation of transforming growth factor beta2 production (GO:0032909)2.80436066
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.80325199
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80325199
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80325199
80establishment of protein localization to Golgi (GO:0072600)2.80249351
81* inner ear receptor cell development (GO:0060119)2.79967665
82oocyte development (GO:0048599)2.79669118
83regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.78058578
84substrate-dependent cell migration (GO:0006929)2.77797365
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77699516
86mitotic metaphase plate congression (GO:0007080)2.76988450
87establishment of chromosome localization (GO:0051303)2.76974536
88nuclear pore complex assembly (GO:0051292)2.76395270
89phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.76171700
90somite rostral/caudal axis specification (GO:0032525)2.75211145
91morphogenesis of an epithelial sheet (GO:0002011)2.74703785
92positive regulation of histone deacetylation (GO:0031065)2.73972315
93limb bud formation (GO:0060174)2.73650076
94negative regulation of bone remodeling (GO:0046851)2.72628728
95hippo signaling (GO:0035329)2.71635885
96negative regulation of keratinocyte proliferation (GO:0010839)2.70804736
97regulation of centrosome duplication (GO:0010824)2.70277690
98regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.70274744
99signal peptide processing (GO:0006465)2.69539979
100regulation of centrosome cycle (GO:0046605)2.65741281
101endoderm development (GO:0007492)2.65533650
102regulation of growth hormone secretion (GO:0060123)2.65025340
103sister chromatid segregation (GO:0000819)2.64810366
104response to endoplasmic reticulum stress (GO:0034976)2.62551434
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62374458
106olfactory bulb development (GO:0021772)2.61701595
107cellular response to vitamin D (GO:0071305)2.61409035
108cell migration involved in sprouting angiogenesis (GO:0002042)2.61391902
109positive regulation of guanylate cyclase activity (GO:0031284)2.60847724
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.60546707
111axon extension involved in axon guidance (GO:0048846)2.60546707
112stress granule assembly (GO:0034063)2.59904117
113monoubiquitinated protein deubiquitination (GO:0035520)2.58646335
114cellular response to hepatocyte growth factor stimulus (GO:0035729)2.58333018
115response to hepatocyte growth factor (GO:0035728)2.58333018
116regulation of RNA export from nucleus (GO:0046831)2.56941619
117regulation of guanylate cyclase activity (GO:0031282)2.56526859
118cellular zinc ion homeostasis (GO:0006882)2.56392872
119negative regulation of meiosis (GO:0045835)2.53887813
120response to X-ray (GO:0010165)2.53854531
121histone lysine demethylation (GO:0070076)2.53790700
122regulation of gene silencing (GO:0060968)2.52845473
123adaptation of signaling pathway (GO:0023058)2.52505208
124regulation of hippo signaling (GO:0035330)2.50929433
125chromatin assembly (GO:0031497)2.49085605
126histone H3-K4 trimethylation (GO:0080182)2.48026118
127protein N-linked glycosylation via asparagine (GO:0018279)2.47544931
128gastrulation with mouth forming second (GO:0001702)2.47472845
129nuclear pore organization (GO:0006999)2.47311765
1303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.47179405
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.47179405
132zinc ion homeostasis (GO:0055069)2.46799488
133peptidyl-asparagine modification (GO:0018196)2.46633375
134epithelial cell fate commitment (GO:0072148)2.46396087
135positive regulation of insulin secretion (GO:0032024)2.46293348
136germ cell migration (GO:0008354)2.45280966
137CENP-A containing nucleosome assembly (GO:0034080)2.45172802
138corticosteroid receptor signaling pathway (GO:0031958)2.44554931
139Golgi organization (GO:0007030)2.43965243
140mitotic chromosome condensation (GO:0007076)2.43865316
141chondrocyte proliferation (GO:0035988)2.43758761
142ganglion development (GO:0061548)2.41680457
143regulation of fibroblast apoptotic process (GO:2000269)2.41153795
144regulation of interferon-beta biosynthetic process (GO:0045357)2.41030704
145negative regulation of histone methylation (GO:0031061)2.40699481
146NLS-bearing protein import into nucleus (GO:0006607)2.40384574
147glucocorticoid receptor signaling pathway (GO:0042921)2.40048043
148positive regulation of SMAD protein import into nucleus (GO:0060391)2.40033212
149replicative senescence (GO:0090399)2.39876975
150genitalia morphogenesis (GO:0035112)2.38745233
151negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.37854205
152dorsal/ventral axis specification (GO:0009950)2.37746477
153protein prenylation (GO:0018342)2.37037486
154prenylation (GO:0097354)2.37037486
155glomerular visceral epithelial cell development (GO:0072015)2.36788469
156regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.36665217
157regulation of mitotic metaphase/anaphase transition (GO:0030071)2.36665217
158centriole replication (GO:0007099)2.36378059
159DNA damage induced protein phosphorylation (GO:0006975)2.35944297
160histone demethylation (GO:0016577)2.35564766
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34411076
162positive regulation by organism of defense response of other organism involved in symbiotic interact2.34411076
163modulation by symbiont of host immune response (GO:0052553)2.34411076
164positive regulation by symbiont of host defense response (GO:0052509)2.34411076
165modulation by symbiont of host defense response (GO:0052031)2.34411076
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34411076
167spindle checkpoint (GO:0031577)2.34375029
168positive regulation of chromosome segregation (GO:0051984)2.34292820
169acrosome assembly (GO:0001675)2.34075530
170nucleus organization (GO:0006997)2.33935182
171mitotic spindle organization (GO:0007052)2.33858164
172negative regulation of glycogen biosynthetic process (GO:0045719)2.33476185
173establishment of nucleus localization (GO:0040023)2.33311578
174mitotic G2/M transition checkpoint (GO:0044818)2.33292041
175regulation of mitotic sister chromatid separation (GO:0010965)2.32594052
176regulation of mitotic sister chromatid segregation (GO:0033047)2.32594052
177regulation of sister chromatid segregation (GO:0033045)2.32594052
178positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32227383
179chondrocyte development (GO:0002063)2.32164646
180regulation of protein polyubiquitination (GO:1902914)2.31635828
181regulation of penile erection (GO:0060405)2.30954641
182centrosome duplication (GO:0051298)2.30565325
183regulation of insulin secretion (GO:0050796)2.29010545
184L-alpha-amino acid transmembrane transport (GO:1902475)2.28597805
185angiotensin maturation (GO:0002003)2.27257565
186activation of Rac GTPase activity (GO:0032863)2.27058854
187protein N-linked glycosylation (GO:0006487)2.25734982
188retinal rod cell development (GO:0046548)2.23544143
189epithelial cell maturation (GO:0002070)2.22990841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.12993584
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.92294790
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.47594272
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02558278
5GATA1_22025678_ChIP-Seq_K562_Human2.73943206
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.61056098
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.54847358
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34420319
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33054993
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24857409
11GBX2_23144817_ChIP-Seq_PC3_Human2.24165930
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19018457
13TAF15_26573619_Chip-Seq_HEK293_Human2.17714463
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.15929368
15* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04229531
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.99369660
17E2F7_22180533_ChIP-Seq_HELA_Human1.99117498
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94989492
19PKCTHETA_26484144_Chip-Seq_BREAST_Human1.92392645
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90155113
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89806960
22EWS_26573619_Chip-Seq_HEK293_Human1.89675642
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86782266
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86248817
25P300_19829295_ChIP-Seq_ESCs_Human1.82007233
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77666648
27FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.77657734
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77246402
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76813129
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.74240550
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71747091
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.71570970
33* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68395806
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64366874
35AR_21909140_ChIP-Seq_LNCAP_Human1.63310557
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.58968387
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.55958204
38TP53_18474530_ChIP-ChIP_U2OS_Human1.55076390
39* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52225743
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50899285
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.50818624
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50440275
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46599144
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42703842
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42031251
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.41869358
47* ELK1_19687146_ChIP-ChIP_HELA_Human1.39690422
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.39103941
49* BRD4_25478319_ChIP-Seq_HGPS_Human1.39037648
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.39016519
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38567310
52FUS_26573619_Chip-Seq_HEK293_Human1.38385571
53TP53_16413492_ChIP-PET_HCT116_Human1.38361605
54GATA6_25053715_ChIP-Seq_YYC3_Human1.37219290
55IGF1R_20145208_ChIP-Seq_DFB_Human1.35911483
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34396394
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33109258
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32850830
59TBX3_20139965_ChIP-Seq_ESCs_Mouse1.31989422
60TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31632460
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31587623
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30327315
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30304373
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30251774
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.28643253
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28170403
67* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27200804
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26497706
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26413088
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26413088
71FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.25773413
72CLOCK_20551151_ChIP-Seq_293T_Human1.25768302
73TCF4_23295773_ChIP-Seq_U87_Human1.25638424
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.25384814
75* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23583150
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22880915
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22700035
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21655573
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21439053
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21247658
81CBP_20019798_ChIP-Seq_JUKART_Human1.21247658
82STAT3_23295773_ChIP-Seq_U87_Human1.20514147
83ZNF274_21170338_ChIP-Seq_K562_Hela1.18404949
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17314450
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.16594869
86AR_25329375_ChIP-Seq_VCAP_Human1.16486326
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16338379
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.16076579
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15511133
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15304352
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14777094
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13415804
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13390079
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13086738
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12956306
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.12433143
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12391972
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12226296
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12048491
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11672935
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11478313
102MYC_22102868_ChIP-Seq_BL_Human1.11204807
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11152481
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11152481
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10967939
106MYB_26560356_Chip-Seq_TH2_Human1.10822206
107SOX9_26525672_Chip-Seq_HEART_Mouse1.10692465
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10074439
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.10029598
110CHD1_26751641_Chip-Seq_LNCaP_Human1.09774163
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09453672
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.09259908
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08181522
114KDM2B_26808549_Chip-Seq_REH_Human1.08180392
115MYB_26560356_Chip-Seq_TH1_Human1.07908881
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07827387
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.07680091
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06123444
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05914155
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05415736
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.04259025
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02992733
123EZH2_22144423_ChIP-Seq_EOC_Human1.02172057
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.01727115
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.00554851
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.00339847
127AHR_22903824_ChIP-Seq_MCF-7_Human1.00160969
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98598093
129ISL1_27105846_Chip-Seq_CPCs_Mouse0.98589985
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98188619
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97933940
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97250459
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97182495
134P53_22387025_ChIP-Seq_ESCs_Mouse0.96741068
135SMAD4_21799915_ChIP-Seq_A2780_Human0.96024374
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95657132
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95638703
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95223897
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95048539
140BCAT_22108803_ChIP-Seq_LS180_Human0.94597430
141TCF7_22412390_ChIP-Seq_EML_Mouse0.92231180
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92181372
143TFEB_21752829_ChIP-Seq_HELA_Human0.91716201
144KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91574694
145* IRF8_27001747_Chip-Seq_BMDM_Mouse0.90658178
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89828998
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89828998
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89250111
149SOX2_20726797_ChIP-Seq_SW620_Human0.88851354
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86976233
151GATA3_27048872_Chip-Seq_THYMUS_Human0.86622166
152* PU_27001747_Chip-Seq_BMDM_Mouse0.86380895
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85825527
154* CJUN_26792858_Chip-Seq_BT549_Human0.85297733
155FOXA1_25552417_ChIP-Seq_VCAP_Human0.83344924
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83303634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.70949523
2MP0008057_abnormal_DNA_replication4.70501081
3MP0003283_abnormal_digestive_organ4.31518210
4MP0009780_abnormal_chondrocyte_physiolo3.99659676
5MP0003300_gastrointestinal_ulcer3.57220012
6MP0009697_abnormal_copulation3.45690930
7MP0000569_abnormal_digit_pigmentation3.11121761
8MP0010234_abnormal_vibrissa_follicle2.97128117
9MP0003941_abnormal_skin_development2.82466421
10* MP0006072_abnormal_retinal_apoptosis2.76019681
11MP0002693_abnormal_pancreas_physiology2.74695474
12MP0003183_abnormal_peptide_metabolism2.71385735
13MP0010352_gastrointestinal_tract_polyps2.52350469
14MP0005076_abnormal_cell_differentiation2.45214567
15MP0006054_spinal_hemorrhage2.25407747
16MP0002909_abnormal_adrenal_gland2.22766991
17MP0004264_abnormal_extraembryonic_tissu2.19620081
18MP0001944_abnormal_pancreas_morphology2.18414165
19MP0000678_abnormal_parathyroid_gland2.02531066
20* MP0005551_abnormal_eye_electrophysiolog2.01825820
21* MP0005253_abnormal_eye_physiology1.97601695
22MP0000462_abnormal_digestive_system1.90499120
23MP0008877_abnormal_DNA_methylation1.88814085
24MP0000778_abnormal_nervous_system1.87680614
25MP0002234_abnormal_pharynx_morphology1.86724038
26MP0003718_maternal_effect1.85861154
27MP0010094_abnormal_chromosome_stability1.80193839
28MP0002896_abnormal_bone_mineralization1.79576519
29MP0000013_abnormal_adipose_tissue1.77041254
30MP0003890_abnormal_embryonic-extraembry1.75593459
31MP0010386_abnormal_urinary_bladder1.69286635
32MP0004272_abnormal_basement_membrane1.69012619
33MP0002697_abnormal_eye_size1.68587171
34MP0010307_abnormal_tumor_latency1.67097116
35MP0002009_preneoplasia1.66359770
36MP0005379_endocrine/exocrine_gland_phen1.65241551
37MP0000427_abnormal_hair_cycle1.60654745
38MP0008438_abnormal_cutaneous_collagen1.59876900
39MP0003787_abnormal_imprinting1.58566678
40MP0003866_abnormal_defecation1.58363391
41MP0001299_abnormal_eye_distance/1.56988190
42MP0003045_fibrosis1.54389456
43MP0008932_abnormal_embryonic_tissue1.52483218
44MP0001849_ear_inflammation1.47774260
45MP0001286_abnormal_eye_development1.47303875
46MP0002928_abnormal_bile_duct1.46745362
47MP0002233_abnormal_nose_morphology1.46739104
48MP0005623_abnormal_meninges_morphology1.45653961
49MP0010030_abnormal_orbit_morphology1.39105528
50MP0001324_abnormal_eye_pigmentation1.36900637
51MP0002092_abnormal_eye_morphology1.33362858
52MP0002638_abnormal_pupillary_reflex1.31491991
53MP0005380_embryogenesis_phenotype1.30904816
54MP0001672_abnormal_embryogenesis/_devel1.30904816
55MP0005220_abnormal_exocrine_pancreas1.29262636
56MP0006292_abnormal_olfactory_placode1.27820245
57MP0001879_abnormal_lymphatic_vessel1.27366938
58MP0005187_abnormal_penis_morphology1.27120506
59MP0004957_abnormal_blastocyst_morpholog1.26964165
60MP0003385_abnormal_body_wall1.26624521
61MP0003984_embryonic_growth_retardation1.24128399
62MP0003077_abnormal_cell_cycle1.23299945
63MP0002088_abnormal_embryonic_growth/wei1.21839732
64MP0010678_abnormal_skin_adnexa1.21459123
65MP0003119_abnormal_digestive_system1.20918052
66MP0005197_abnormal_uvea_morphology1.20769421
67MP0005310_abnormal_salivary_gland1.19639341
68MP0005248_abnormal_Harderian_gland1.19061326
69MP0003121_genomic_imprinting1.18942248
70MP0003091_abnormal_cell_migration1.18870580
71MP0002751_abnormal_autonomic_nervous1.18282097
72MP0003567_abnormal_fetal_cardiomyocyte1.17759528
73MP0005394_taste/olfaction_phenotype1.17606823
74MP0005499_abnormal_olfactory_system1.17606823
75MP0003111_abnormal_nucleus_morphology1.17242084
76MP0001915_intracranial_hemorrhage1.16338764
77MP0001177_atelectasis1.15885511
78* MP0005391_vision/eye_phenotype1.15538111
79MP0002085_abnormal_embryonic_tissue1.14288887
80MP0001188_hyperpigmentation1.14226831
81MP0004233_abnormal_muscle_weight1.14199024
82MP0003172_abnormal_lysosome_physiology1.11007126
83MP0009672_abnormal_birth_weight1.09691535
84MP0000647_abnormal_sebaceous_gland1.09499297
85MP0003252_abnormal_bile_duct1.09019949
86MP0000762_abnormal_tongue_morphology1.08517277
87MP0002166_altered_tumor_susceptibility1.08239548
88MP0000579_abnormal_nail_morphology1.07009518
89MP0002078_abnormal_glucose_homeostasis1.05495022
90MP0003303_peritoneal_inflammation1.05066900
91MP0004134_abnormal_chest_morphology1.04830753
92MP0003221_abnormal_cardiomyocyte_apopto1.04076835
93MP0000383_abnormal_hair_follicle1.04075925
94MP0003705_abnormal_hypodermis_morpholog1.03293366
95MP0000003_abnormal_adipose_tissue1.02945717
96MP0005395_other_phenotype1.02918551
97MP0009703_decreased_birth_body1.01810924
98MP0003315_abnormal_perineum_morphology1.01363214
99MP0003861_abnormal_nervous_system1.00068814
100MP0005275_abnormal_skin_tensile0.99700898
101MP0000631_abnormal_neuroendocrine_gland0.99303350
102MP0001730_embryonic_growth_arrest0.99188623
103MP0005257_abnormal_intraocular_pressure0.96251885
104MP0010155_abnormal_intestine_physiology0.94977322
105MP0001666_abnormal_nutrient_absorption0.94769097
106MP0003950_abnormal_plasma_membrane0.94455144
107MP0000428_abnormal_craniofacial_morphol0.94228413
108MP0003868_abnormal_feces_composition0.94045386
109MP0003123_paternal_imprinting0.93099856
110MP0009053_abnormal_anal_canal0.92224584
111MP0003566_abnormal_cell_adhesion0.91654302
112MP0000490_abnormal_crypts_of0.91538260
113MP0001697_abnormal_embryo_size0.90833272
114MP0005409_darkened_coat_color0.90226117
115MP0001986_abnormal_taste_sensitivity0.89925009
116MP0008058_abnormal_DNA_repair0.88830148
117MP0002184_abnormal_innervation0.88373673
118MP0000767_abnormal_smooth_muscle0.88012010
119MP0002876_abnormal_thyroid_physiology0.87803711
120MP0002925_abnormal_cardiovascular_devel0.87769843
121MP0002109_abnormal_limb_morphology0.87639634
122MP0000350_abnormal_cell_proliferation0.85143815
123MP0008007_abnormal_cellular_replicative0.84672023
124MP0003935_abnormal_craniofacial_develop0.83856490
125MP0000163_abnormal_cartilage_morphology0.82221466
126MP0004084_abnormal_cardiac_muscle0.82210330
127MP0000516_abnormal_urinary_system0.82185666
128MP0005367_renal/urinary_system_phenotyp0.82185666
129MP0004197_abnormal_fetal_growth/weight/0.81026810
130MP0002081_perinatal_lethality0.80517596
131MP0002938_white_spotting0.80003606
132MP0000681_abnormal_thyroid_gland0.79850324
133* MP0005195_abnormal_posterior_eye0.79800631
134MP0008789_abnormal_olfactory_epithelium0.79588216
135MP0002006_tumorigenesis0.79579609
136MP0008961_abnormal_basal_metabolism0.79424819
137MP0002111_abnormal_tail_morphology0.79076029
138MP0005381_digestive/alimentary_phenotyp0.76052217
139MP0003795_abnormal_bone_structure0.75970469
140MP0000477_abnormal_intestine_morphology0.74795784
141MP0003436_decreased_susceptibility_to0.74001890
142MP0001293_anophthalmia0.72752479
143MP0000613_abnormal_salivary_gland0.71822257
144MP0002177_abnormal_outer_ear0.71517526
145MP0000432_abnormal_head_morphology0.70802154
146MP0004185_abnormal_adipocyte_glucose0.68864929
147MP0002084_abnormal_developmental_patter0.67971340
148MP0000733_abnormal_muscle_development0.67609049
149MP0000538_abnormal_urinary_bladder0.64900909
150MP0003937_abnormal_limbs/digits/tail_de0.64512079
151MP0002089_abnormal_postnatal_growth/wei0.64249238
152MP0005058_abnormal_lysosome_morphology0.62728841
153MP0002998_abnormal_bone_remodeling0.60649835
154MP0002113_abnormal_skeleton_development0.60496354
155MP0001790_abnormal_immune_system0.59513389
156MP0005387_immune_system_phenotype0.59513389
157MP0002086_abnormal_extraembryonic_tissu0.59391182
158MP0003755_abnormal_palate_morphology0.59332681
159* MP0004043_abnormal_pH_regulation0.58923137
160MP0000537_abnormal_urethra_morphology0.58422635
161MP0004947_skin_inflammation0.58267480
162MP0004808_abnormal_hematopoietic_stem0.58224653
163MP0003693_abnormal_embryo_hatching0.57688007
164MP0002116_abnormal_craniofacial_bone0.57251927

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.90075264
2Symptomatic seizures (HP:0011145)3.78402175
3Bony spicule pigmentary retinopathy (HP:0007737)3.70364992
4Hypoglycemic seizures (HP:0002173)3.69159127
5Hyperinsulinemic hypoglycemia (HP:0000825)3.58487788
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.52766676
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.41571870
8Abnormal rod and cone electroretinograms (HP:0008323)3.25660137
9Pigmentary retinal degeneration (HP:0001146)3.18661526
10Chorioretinal atrophy (HP:0000533)3.09747232
11Insulin-resistant diabetes mellitus (HP:0000831)2.99013858
12Chromsome breakage (HP:0040012)2.98602633
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86805044
14Type II diabetes mellitus (HP:0005978)2.86122364
15Central scotoma (HP:0000603)2.85682470
16Macroorchidism (HP:0000053)2.69792081
17Posterior subcapsular cataract (HP:0007787)2.68188349
18Thoracolumbar scoliosis (HP:0002944)2.62087851
19Cone-rod dystrophy (HP:0000548)2.60006248
20Vitreoretinal degeneration (HP:0000655)2.59078555
21Curly hair (HP:0002212)2.54841176
22Absent frontal sinuses (HP:0002688)2.53778808
23Hyperglycemia (HP:0003074)2.48600399
24Decreased circulating renin level (HP:0003351)2.47421263
25Cortical dysplasia (HP:0002539)2.46676760
26Vertebral arch anomaly (HP:0008438)2.46114308
27Thick nail (HP:0001805)2.41898989
28Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.39130768
29Mucopolysacchariduria (HP:0008155)2.38262794
30Urinary glycosaminoglycan excretion (HP:0003541)2.38262794
31Papillary thyroid carcinoma (HP:0002895)2.37987457
32Volvulus (HP:0002580)2.33146347
33Cupped ribs (HP:0000887)2.32557141
34Flat acetabular roof (HP:0003180)2.31985417
35Facial hemangioma (HP:0000329)2.29718917
36Fair hair (HP:0002286)2.28080306
37Cervical subluxation (HP:0003308)2.27759916
38Dyschromatopsia (HP:0007641)2.26472225
39Pulmonic stenosis (HP:0001642)2.24806010
40Abdominal distention (HP:0003270)2.21720804
41Attenuation of retinal blood vessels (HP:0007843)2.21651300
42Abnormality of macular pigmentation (HP:0008002)2.21512064
43Flattened epiphyses (HP:0003071)2.21353616
44Abnormality of chromosome stability (HP:0003220)2.20614942
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20385185
46Abnormality of polysaccharide metabolism (HP:0011012)2.20385185
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20385185
48Abnormal foot bone ossification (HP:0010675)2.19821733
49Hepatoblastoma (HP:0002884)2.17613961
50Constricted visual fields (HP:0001133)2.16472405
51Chronic diarrhea (HP:0002028)2.15732290
52Abnormal pancreas size (HP:0012094)2.13168821
53Heterotopia (HP:0002282)2.12274880
54Subacute progressive viral hepatitis (HP:0006572)2.12230830
55Transitional cell carcinoma of the bladder (HP:0006740)2.11748789
56Short chin (HP:0000331)2.10877761
57Overgrowth (HP:0001548)2.10875696
58Deep philtrum (HP:0002002)2.10558158
59Abnormal biliary tract morphology (HP:0012440)2.10203204
60Thyroid carcinoma (HP:0002890)2.10088053
61Retinal atrophy (HP:0001105)2.09465956
62Ankle contracture (HP:0006466)2.07410732
63Epiphyseal dysplasia (HP:0002656)2.07376274
64Osteomalacia (HP:0002749)2.07347947
65Bladder carcinoma (HP:0002862)2.07013988
66Bladder neoplasm (HP:0009725)2.07013988
67Abnormality of the proximal phalanges of the hand (HP:0009834)2.05006419
68Nephroblastoma (Wilms tumor) (HP:0002667)2.04570118
69Spondylolisthesis (HP:0003302)2.03993201
70Colon cancer (HP:0003003)2.03021162
71Photophobia (HP:0000613)2.02638767
72Arterial tortuosity (HP:0005116)2.02086592
73Rhabdomyosarcoma (HP:0002859)2.01965182
74Pendular nystagmus (HP:0012043)2.01167546
75Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00976518
76Wrist flexion contracture (HP:0001239)2.00558898
77Embryonal renal neoplasm (HP:0011794)2.00269386
78Scotoma (HP:0000575)2.00254532
79Hematochezia (HP:0002573)2.00187463
80Severe short stature (HP:0003510)1.98767251
81Gastrointestinal carcinoma (HP:0002672)1.98767239
82Malignant gastrointestinal tract tumors (HP:0006749)1.98767239
83Leiomyosarcoma (HP:0100243)1.97499177
84Uterine leiomyosarcoma (HP:0002891)1.97499177
85Spinal muscular atrophy (HP:0007269)1.96944341
86Abnormality of the pancreatic islet cells (HP:0006476)1.96012809
87Abnormality of endocrine pancreas physiology (HP:0012093)1.96012809
88Septo-optic dysplasia (HP:0100842)1.95664373
89Abnormality of the 1st metacarpal (HP:0010009)1.95416754
90Broad face (HP:0000283)1.95207001
91Spinal cord lesions (HP:0100561)1.94647332
92Syringomyelia (HP:0003396)1.94647332
93Drooling (HP:0002307)1.94290858
94Capillary hemangiomas (HP:0005306)1.93090897
95Oligodactyly (hands) (HP:0001180)1.92991887
96Congenital sensorineural hearing impairment (HP:0008527)1.92513761
97Relative macrocephaly (HP:0004482)1.92477339
98Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90650907
99Abnormality of abdominal situs (HP:0011620)1.89939058
100Abdominal situs inversus (HP:0003363)1.89939058
101Aortic dissection (HP:0002647)1.89733893
102Pancreatic islet-cell hyperplasia (HP:0004510)1.88755925
103Hypoglycemic coma (HP:0001325)1.88043582
104Aortic aneurysm (HP:0004942)1.87696644
105Abnormality of the frontal sinuses (HP:0002687)1.86337631
106Atrophic scars (HP:0001075)1.86026291
107Cystic hygroma (HP:0000476)1.84573129
108Abnormality of the fingertips (HP:0001211)1.84562955
109Meckel diverticulum (HP:0002245)1.83887848
110Truncal obesity (HP:0001956)1.83808113
111Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83187851
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.82717318
113Biliary tract neoplasm (HP:0100574)1.81943971
114Broad ribs (HP:0000885)1.81284231
115Abnormality of the hip-girdle musculature (HP:0001445)1.81234056
116Abnormality of the musculature of the pelvis (HP:0001469)1.81234056
117Sandal gap (HP:0001852)1.80010982
118Abolished electroretinogram (ERG) (HP:0000550)1.78385487
119Abnormality of calcium-phosphate metabolism (HP:0100530)1.77797449
120Flat capital femoral epiphysis (HP:0003370)1.77695961
121Selective tooth agenesis (HP:0001592)1.76948935
122Bifid tongue (HP:0010297)1.76251703
123Lip pit (HP:0100267)1.75162123
124Elfin facies (HP:0004428)1.74513151
125Narrow palate (HP:0000189)1.71997835
126Absent eyebrow (HP:0002223)1.71967983
127Skull defect (HP:0001362)1.70969950
128Thyroiditis (HP:0100646)1.70522049
129Premature rupture of membranes (HP:0001788)1.70437786
130Inappropriate behavior (HP:0000719)1.70032360
131Abnormality of the ileum (HP:0001549)1.68931265
132Excessive salivation (HP:0003781)1.68843540
133Hypoplastic ischia (HP:0003175)1.68061227
134Decreased central vision (HP:0007663)1.67813171
135Dysostosis multiplex (HP:0000943)1.67508858
136High anterior hairline (HP:0009890)1.67458275
137Abnormality of small intestinal villus morphology (HP:0011472)1.66539928
138Villous atrophy (HP:0011473)1.66539928
139Spinal cord compression (HP:0002176)1.65657722
140Abnormality of the septum pellucidum (HP:0007375)1.65337997
141Vertebral clefting (HP:0008428)1.64926782
142Increased number of teeth (HP:0011069)1.64864012
143Aqueductal stenosis (HP:0002410)1.64580951
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64398625
145Short 4th metacarpal (HP:0010044)1.64398625
146Pelvic girdle muscle weakness (HP:0003749)1.64305701
147Disinhibition (HP:0000734)1.63013289
148Shallow orbits (HP:0000586)1.63000723
149Astrocytoma (HP:0009592)1.62707828
150Abnormality of the astrocytes (HP:0100707)1.62707828
151Mitral valve prolapse (HP:0001634)1.62632558
152Abnormal tarsal ossification (HP:0008369)1.62603335
153Abnormality of oral frenula (HP:0000190)1.62455620
154Hyperkalemia (HP:0002153)1.62254096
155Acute myeloid leukemia (HP:0004808)1.61943386
156Abnormality of the nasal septum (HP:0000419)1.61556574
157Short humerus (HP:0005792)1.61225479
158Supernumerary spleens (HP:0009799)1.60723896
159Shoulder girdle muscle weakness (HP:0003547)1.60636730
160Abnormal lung lobation (HP:0002101)1.60111933
161Vascular tortuosity (HP:0004948)1.60030500
162Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.58730191
163Hypoplastic labia majora (HP:0000059)1.58658504
164Micronodular cirrhosis (HP:0001413)1.58616041
165Mildly elevated creatine phosphokinase (HP:0008180)1.58592045
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58468449
167Smooth philtrum (HP:0000319)1.58406837
168Prominent metopic ridge (HP:0005487)1.58191082
169Abnormality of the distal phalanges of the toes (HP:0010182)1.58189971
170Hypoplastic scapulae (HP:0000882)1.58115453
171Aplasia/Hypoplasia of the scapulae (HP:0006713)1.58115453
172Neoplasm of the small intestine (HP:0100833)1.57896293
173Large earlobe (HP:0009748)1.57549675
174Deep palmar crease (HP:0006191)1.56679437
175Medulloblastoma (HP:0002885)1.56182851
176Fibular hypoplasia (HP:0003038)1.56001802
177Omphalocele (HP:0001539)1.55881164
178Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55807985
179Short 1st metacarpal (HP:0010034)1.55807985
180Metaphyseal dysplasia (HP:0100255)1.55057706
181Severe visual impairment (HP:0001141)1.55037018
182Prominent forehead (HP:0011220)1.54965196
183Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.53705889
184Limited elbow extension (HP:0001377)1.53563698
185Abnormality of the epiphyses of the hand (HP:0005924)1.53332062
186Enlarged penis (HP:0000040)1.53319745
187Irregular vertebral endplates (HP:0003301)1.53244106
188Coronal craniosynostosis (HP:0004440)1.52909946
189Exostoses (HP:0100777)1.52550449
190Agnosia (HP:0010524)1.52384958
191Protruding tongue (HP:0010808)1.51967533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.87617482
2FRK4.02508353
3PASK3.83605399
4CDK123.72889809
5TAOK33.54914938
6MAP3K22.98040461
7CASK2.36750011
8BRD42.35929029
9SCYL22.31669632
10HIPK22.13239682
11PDGFRA2.12866526
12PNCK2.09546661
13MAP3K42.00498918
14MAP3K101.91268104
15LATS11.79191499
16STK38L1.75925946
17JAK31.74750647
18TAF11.66808762
19SRPK11.63913771
20FLT31.63330263
21ACVR1B1.58641863
22NUAK11.50577197
23MAPK151.50425934
24PTK61.49962392
25PLK41.45787148
26BRSK21.45701976
27TTK1.43056866
28MKNK11.41812376
29IRAK31.40983346
30EPHB21.38735058
31WNK31.34388017
32ERBB41.32308390
33ERBB31.31797401
34CAMK1G1.30686106
35DYRK1B1.28485338
36LATS21.25921941
37CAMK1D1.24108975
38TSSK61.23414548
39PLK21.21816956
40CDK91.18728282
41STK241.18285214
42DDR21.16731484
43EPHA31.13955813
44PDGFRB1.11045595
45CDC42BPA1.10638077
46FGFR31.09141089
47MAP2K71.08424105
48NEK91.07228328
49PLK31.04650734
50BMPR1B1.03765132
51NTRK31.01130394
52TGFBR21.01075527
53MET0.99920903
54TGFBR10.97752524
55CDK60.95917484
56CHUK0.94660333
57STK390.93624718
58MAP3K140.87388792
59MST40.87285397
60RIPK40.87192081
61AKT30.86975799
62ITK0.85351366
63BRAF0.85350877
64STK30.84737398
65MARK10.84643587
66TRIM280.83902274
67SGK20.82802857
68PTK20.80712238
69DYRK30.79611454
70YES10.79126332
71MAP3K70.77687651
72JAK10.77632678
73WEE10.77024769
74PRKD30.75520671
75CAMKK20.75421568
76EPHA20.74503990
77NEK60.73294524
78MAP3K90.72727029
79CSK0.72446563
80TTN0.71840180
81MKNK20.71815136
82MTOR0.68377244
83MAP3K30.68224062
84TNIK0.67353829
85PLK10.67174799
86RPS6KB10.65686768
87EEF2K0.63678727
88MELK0.63283926
89ATM0.62895723
90DYRK1A0.62280251
91RIPK10.61584254
92GRK10.60646936
93IGF1R0.60414787
94PIK3CA0.59408113
95KSR10.58653961
96PRKCH0.57849841
97NTRK10.57393859
98MARK20.57302938
99JAK20.57267366
100PKN20.56959017
101PRKG20.56800436
102MARK30.56636354
103CSNK1A1L0.56222728
104IRAK10.55383236
105CSNK1G10.54884948
106MST1R0.54603754
107ERN10.53521383
108EIF2AK30.53407757
109MAPK140.52865371
110PRKDC0.52602592
111RPS6KA40.52423294
112MAP3K80.51916504
113RPS6KA20.51689870
114PRKAA20.50943614
115ALK0.49861901
116ZAK0.48418173
117CHEK20.47481643
118CDK80.47113045
119PAK40.47091206
120OBSCN0.47046155
121TESK10.47014927
122MAP3K10.45624539
123PAK20.45619853
124MAP3K60.45585575
125WNK10.45536721
126DMPK0.45179125
127NLK0.42089008
128PRKD20.41920089
129TEC0.41830086
130BCR0.41422012
131PRKAA10.41399902
132CSNK1G20.40929915
133INSR0.40571511
134PRKCI0.40250694
135STK100.40108515
136MAPK100.38815564
137FGFR10.38427908
138CHEK10.37661854
139ATR0.37238439
140CDC70.36307979
141IRAK20.36293044
142PAK30.36040396
143EGFR0.35664425
144AURKB0.35300096
145FER0.34507124
146LCK0.34147982
147GSK3B0.33953526
148SGK30.33912876
149MAPK130.33604588
150CAMK40.33287427
151SGK2230.32831189
152SGK4940.32831189
153CSNK1D0.29080909
154EPHA40.29058478
155NTRK20.29022991
156MAP2K40.28780677
157TIE10.28414930

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.76416561
2Phototransduction_Homo sapiens_hsa047443.37824470
3Non-homologous end-joining_Homo sapiens_hsa034502.93717732
4Cell cycle_Homo sapiens_hsa041102.47377986
5Sulfur metabolism_Homo sapiens_hsa009202.36381910
6Carbohydrate digestion and absorption_Homo sapiens_hsa049732.08999617
7Type II diabetes mellitus_Homo sapiens_hsa049302.08923547
8Basal transcription factors_Homo sapiens_hsa030222.01917223
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99926380
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98484328
11Protein export_Homo sapiens_hsa030601.97077916
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.92274312
13TGF-beta signaling pathway_Homo sapiens_hsa043501.77003724
14Hippo signaling pathway_Homo sapiens_hsa043901.76388692
15Insulin secretion_Homo sapiens_hsa049111.71856763
16ECM-receptor interaction_Homo sapiens_hsa045121.64328655
17Type I diabetes mellitus_Homo sapiens_hsa049401.63192941
18Fanconi anemia pathway_Homo sapiens_hsa034601.57063405
19Steroid biosynthesis_Homo sapiens_hsa001001.55099074
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54388544
21Mismatch repair_Homo sapiens_hsa034301.52247285
22Axon guidance_Homo sapiens_hsa043601.49620104
23p53 signaling pathway_Homo sapiens_hsa041151.49089856
24RNA transport_Homo sapiens_hsa030131.42375417
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39357293
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36729790
27Nucleotide excision repair_Homo sapiens_hsa034201.35189201
28Mineral absorption_Homo sapiens_hsa049781.32491226
29Hedgehog signaling pathway_Homo sapiens_hsa043401.30032556
30N-Glycan biosynthesis_Homo sapiens_hsa005101.28532903
31Oocyte meiosis_Homo sapiens_hsa041141.23497811
32Adherens junction_Homo sapiens_hsa045201.22345169
33Renal cell carcinoma_Homo sapiens_hsa052111.20051155
34ErbB signaling pathway_Homo sapiens_hsa040121.18403186
35Basal cell carcinoma_Homo sapiens_hsa052171.17716601
36RNA degradation_Homo sapiens_hsa030181.17077626
37Melanoma_Homo sapiens_hsa052181.15873904
38Renin-angiotensin system_Homo sapiens_hsa046141.15869113
39Wnt signaling pathway_Homo sapiens_hsa043101.14658354
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08481414
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08234378
42Prolactin signaling pathway_Homo sapiens_hsa049171.07687026
43Pathways in cancer_Homo sapiens_hsa052001.07662553
44Fat digestion and absorption_Homo sapiens_hsa049751.05193040
45mTOR signaling pathway_Homo sapiens_hsa041501.04703694
46Gap junction_Homo sapiens_hsa045401.04390031
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.03941965
48Chronic myeloid leukemia_Homo sapiens_hsa052200.99877720
49Tight junction_Homo sapiens_hsa045300.96075159
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95022541
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94752342
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93333336
53Circadian rhythm_Homo sapiens_hsa047100.92177959
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91716675
55Antigen processing and presentation_Homo sapiens_hsa046120.91144607
56Prostate cancer_Homo sapiens_hsa052150.91099667
57Galactose metabolism_Homo sapiens_hsa000520.89217461
58Long-term depression_Homo sapiens_hsa047300.88953176
59Cocaine addiction_Homo sapiens_hsa050300.88706342
60Non-small cell lung cancer_Homo sapiens_hsa052230.88461126
61Insulin resistance_Homo sapiens_hsa049310.88423088
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88412694
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.87123547
64Dilated cardiomyopathy_Homo sapiens_hsa054140.86648816
65Rap1 signaling pathway_Homo sapiens_hsa040150.85170422
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83602330
67Osteoclast differentiation_Homo sapiens_hsa043800.82501797
68Inositol phosphate metabolism_Homo sapiens_hsa005620.81935038
69Thyroid hormone synthesis_Homo sapiens_hsa049180.80383851
70TNF signaling pathway_Homo sapiens_hsa046680.80191480
71Leishmaniasis_Homo sapiens_hsa051400.80026185
72Vibrio cholerae infection_Homo sapiens_hsa051100.79126027
73MicroRNAs in cancer_Homo sapiens_hsa052060.76697322
74Long-term potentiation_Homo sapiens_hsa047200.74979293
75Amoebiasis_Homo sapiens_hsa051460.74947869
76Protein digestion and absorption_Homo sapiens_hsa049740.72782358
77Hepatitis B_Homo sapiens_hsa051610.72474065
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71876544
79Estrogen signaling pathway_Homo sapiens_hsa049150.71761479
80Dorso-ventral axis formation_Homo sapiens_hsa043200.71253550
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71065995
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69010856
83Alcoholism_Homo sapiens_hsa050340.68957740
84Endometrial cancer_Homo sapiens_hsa052130.68266837
85Viral carcinogenesis_Homo sapiens_hsa052030.68205785
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67878479
87Pancreatic secretion_Homo sapiens_hsa049720.67530279
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67100096
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67061502
90B cell receptor signaling pathway_Homo sapiens_hsa046620.66683640
91Glioma_Homo sapiens_hsa052140.66122038
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66080052
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.65815244
94Legionellosis_Homo sapiens_hsa051340.65767368
95Pancreatic cancer_Homo sapiens_hsa052120.65705764
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65055914
97Toxoplasmosis_Homo sapiens_hsa051450.64811691
98Proteoglycans in cancer_Homo sapiens_hsa052050.64401176
99Melanogenesis_Homo sapiens_hsa049160.64235993
100Ras signaling pathway_Homo sapiens_hsa040140.63822863
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63440144
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63379132
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63317623
104Cholinergic synapse_Homo sapiens_hsa047250.63170991
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62429962
106Measles_Homo sapiens_hsa051620.61318818
107FoxO signaling pathway_Homo sapiens_hsa040680.61277357
108Chemokine signaling pathway_Homo sapiens_hsa040620.61002780
109Tuberculosis_Homo sapiens_hsa051520.60386144
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59826535
111Homologous recombination_Homo sapiens_hsa034400.59800169
112Influenza A_Homo sapiens_hsa051640.59506677
113Starch and sucrose metabolism_Homo sapiens_hsa005000.59361755
114T cell receptor signaling pathway_Homo sapiens_hsa046600.58793791
115Fatty acid biosynthesis_Homo sapiens_hsa000610.58559734
116Herpes simplex infection_Homo sapiens_hsa051680.58278244
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57610560
118Nicotine addiction_Homo sapiens_hsa050330.57550531
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.57431089
120Glucagon signaling pathway_Homo sapiens_hsa049220.56854074
121Lysine degradation_Homo sapiens_hsa003100.56806758
122Amphetamine addiction_Homo sapiens_hsa050310.56435948
123Thyroid cancer_Homo sapiens_hsa052160.55960099
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55855498
125mRNA surveillance pathway_Homo sapiens_hsa030150.55817666
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55137899
127Colorectal cancer_Homo sapiens_hsa052100.54872245
128GnRH signaling pathway_Homo sapiens_hsa049120.54794859
129Bladder cancer_Homo sapiens_hsa052190.54472942
130Focal adhesion_Homo sapiens_hsa045100.54445763
131Dopaminergic synapse_Homo sapiens_hsa047280.53842870
132Selenocompound metabolism_Homo sapiens_hsa004500.52750295
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52745709
134HTLV-I infection_Homo sapiens_hsa051660.51860144
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51160793
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.51113744
137DNA replication_Homo sapiens_hsa030300.50747847
138Small cell lung cancer_Homo sapiens_hsa052220.50469337
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50326994
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50118897
141Ovarian steroidogenesis_Homo sapiens_hsa049130.49762572
142Lysosome_Homo sapiens_hsa041420.48968405
143Circadian entrainment_Homo sapiens_hsa047130.48800535
144Viral myocarditis_Homo sapiens_hsa054160.48562395
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48469260
146Hematopoietic cell lineage_Homo sapiens_hsa046400.48284610
147HIF-1 signaling pathway_Homo sapiens_hsa040660.47884686
148Insulin signaling pathway_Homo sapiens_hsa049100.46701044
149Sphingolipid metabolism_Homo sapiens_hsa006000.46581169
150Systemic lupus erythematosus_Homo sapiens_hsa053220.45559976
151MAPK signaling pathway_Homo sapiens_hsa040100.45236327
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45171099
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45114932
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.44171841
155Choline metabolism in cancer_Homo sapiens_hsa052310.42763864

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