SLC4A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)5.02273907
2sodium ion export (GO:0071436)4.95682183
3gamma-aminobutyric acid transport (GO:0015812)4.77669675
4alanine transport (GO:0032328)4.20129041
5locomotory exploration behavior (GO:0035641)4.09786904
6cellular sodium ion homeostasis (GO:0006883)4.09718761
7C4-dicarboxylate transport (GO:0015740)4.09656138
8L-amino acid import (GO:0043092)4.05367985
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.82625671
10potassium ion import (GO:0010107)3.78721110
11cell communication by electrical coupling (GO:0010644)3.76043589
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.71477465
13lysine metabolic process (GO:0006553)3.66583520
14lysine catabolic process (GO:0006554)3.66583520
15dicarboxylic acid biosynthetic process (GO:0043650)3.63938900
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55435884
17amino acid import (GO:0043090)3.53325137
18glutamate metabolic process (GO:0006536)3.42187418
19postsynaptic membrane organization (GO:0001941)3.38160921
20negative regulation of sodium ion transport (GO:0010766)3.28479056
21potassium ion homeostasis (GO:0055075)3.28384722
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27144115
23low-density lipoprotein particle remodeling (GO:0034374)3.25531122
24neurotransmitter-gated ion channel clustering (GO:0072578)3.23027831
25neurotransmitter secretion (GO:0007269)3.22210767
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.22103515
27cerebellar granule cell differentiation (GO:0021707)3.20163117
28proline transport (GO:0015824)3.18785013
29phosphate ion transport (GO:0006817)3.17818409
30vocalization behavior (GO:0071625)3.16207146
31drug transmembrane transport (GO:0006855)3.11793606
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11397220
33drug catabolic process (GO:0042737)3.11292032
34alpha-linolenic acid metabolic process (GO:0036109)3.10719488
35urate metabolic process (GO:0046415)3.09072972
36central nervous system myelination (GO:0022010)3.05851685
37axon ensheathment in central nervous system (GO:0032291)3.05851685
38aspartate family amino acid catabolic process (GO:0009068)3.03312774
39phosphate ion transmembrane transport (GO:0035435)3.02943224
40synaptic vesicle maturation (GO:0016188)3.02243247
41glutamate secretion (GO:0014047)3.01576943
42glutamate receptor signaling pathway (GO:0007215)3.00722896
43cysteine metabolic process (GO:0006534)3.00275598
44short-chain fatty acid metabolic process (GO:0046459)2.98930769
45L-phenylalanine catabolic process (GO:0006559)2.97820626
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97820626
47glycine transport (GO:0015816)2.97726918
48exogenous drug catabolic process (GO:0042738)2.97242338
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.95934554
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91574936
51astrocyte differentiation (GO:0048708)2.90433932
52cellular modified amino acid catabolic process (GO:0042219)2.90244337
53neuronal action potential propagation (GO:0019227)2.88309294
54glyoxylate metabolic process (GO:0046487)2.87795331
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85905966
56neuronal ion channel clustering (GO:0045161)2.84949837
57neurotransmitter transport (GO:0006836)2.83218913
58dicarboxylic acid catabolic process (GO:0043649)2.81564235
59transepithelial transport (GO:0070633)2.80481747
60presynaptic membrane assembly (GO:0097105)2.80009822
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79753994
62synaptic transmission, glutamatergic (GO:0035249)2.77765070
63regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.77496182
64L-phenylalanine metabolic process (GO:0006558)2.77086387
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77086387
66acidic amino acid transport (GO:0015800)2.75185843
67one-carbon compound transport (GO:0019755)2.74425605
68myelination in peripheral nervous system (GO:0022011)2.73520133
69peripheral nervous system axon ensheathment (GO:0032292)2.73520133
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72336569
71regulation of glutamate receptor signaling pathway (GO:1900449)2.71947730
72regulation of neurotransmitter levels (GO:0001505)2.71031415
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68753285
74homocysteine metabolic process (GO:0050667)2.68678915
75regulation of cardiac muscle cell contraction (GO:0086004)2.67226158
76amino-acid betaine metabolic process (GO:0006577)2.66245167
77drug transport (GO:0015893)2.65228412
78regulation of cholesterol esterification (GO:0010872)2.65088646
79prepulse inhibition (GO:0060134)2.64556400
80import into cell (GO:0098657)2.63899572
81aromatic amino acid family catabolic process (GO:0009074)2.63633577
82response to auditory stimulus (GO:0010996)2.63541070
83neurotransmitter uptake (GO:0001504)2.62731621
84exploration behavior (GO:0035640)2.62686454
85membrane hyperpolarization (GO:0060081)2.62354659
86cellular ketone body metabolic process (GO:0046950)2.60985081
87regulation of neuronal synaptic plasticity (GO:0048168)2.60845699
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.60618977
89metanephric nephron tubule development (GO:0072234)2.59265340
90metanephric tubule development (GO:0072170)2.59265340
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59250548
92negative regulation of protein localization to cell surface (GO:2000009)2.58967411
93relaxation of cardiac muscle (GO:0055119)2.58965348
94sperm capacitation (GO:0048240)2.58699368
95auditory behavior (GO:0031223)2.58153942
96synaptic vesicle exocytosis (GO:0016079)2.57775249
97regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.56384374
98long-term memory (GO:0007616)2.56277873
99cell communication involved in cardiac conduction (GO:0086065)2.55917889
100cGMP-mediated signaling (GO:0019934)2.55259873
101L-glutamate transport (GO:0015813)2.55105866
102glutamine family amino acid catabolic process (GO:0009065)2.54055088
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.53829535
104regulation of synapse structural plasticity (GO:0051823)2.52938305
105sodium ion homeostasis (GO:0055078)2.52316217
106neuron cell-cell adhesion (GO:0007158)2.52110713
107presynaptic membrane organization (GO:0097090)2.51789050
108nephron tubule formation (GO:0072079)2.50170621
109dicarboxylic acid transport (GO:0006835)2.50056789
110neuron-neuron synaptic transmission (GO:0007270)2.47635968
111aminoglycoside antibiotic metabolic process (GO:0030647)2.47337912
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.44684669
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43055820
114regulation of synaptic vesicle exocytosis (GO:2000300)2.41887308
115quaternary ammonium group transport (GO:0015697)2.40719308
116layer formation in cerebral cortex (GO:0021819)2.39641575
117plasma lipoprotein particle remodeling (GO:0034369)2.39006928
118protein-lipid complex remodeling (GO:0034368)2.39006928
119macromolecular complex remodeling (GO:0034367)2.39006928
120membrane repolarization (GO:0086009)2.38937065
121regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.38465298
122cellular amino acid catabolic process (GO:0009063)2.37386681
123alpha-amino acid catabolic process (GO:1901606)2.36643400
124serine family amino acid catabolic process (GO:0009071)2.36535628
125fluid transport (GO:0042044)2.35507930
126* bicarbonate transport (GO:0015701)2.33656855
127metanephric nephron epithelium development (GO:0072243)2.33449393
128otic vesicle formation (GO:0030916)2.30850679
129relaxation of muscle (GO:0090075)2.28885300
130regulation of synaptic vesicle transport (GO:1902803)2.27780129
131negative regulation of hormone metabolic process (GO:0032351)2.26914828
132photoreceptor cell differentiation (GO:0046530)2.26676739
133eye photoreceptor cell differentiation (GO:0001754)2.26676739
134water transport (GO:0006833)2.26188150
135glomerular basement membrane development (GO:0032836)2.26117980
136macroautophagy (GO:0016236)2.24433881
137righting reflex (GO:0060013)2.23902621
138astrocyte development (GO:0014002)2.22591592
139response to mercury ion (GO:0046689)2.22134391
140regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.21988093
141response to lead ion (GO:0010288)2.21774280
142regulation of protein glycosylation (GO:0060049)2.19739667
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17681724
144nephron tubule development (GO:0072080)2.17220563
145camera-type eye morphogenesis (GO:0048593)2.16377373
146ethanol oxidation (GO:0006069)2.16057375
147positive regulation of potassium ion transport (GO:0043268)2.15303659
148regulation of ARF protein signal transduction (GO:0032012)2.15238573
149negative regulation of hormone biosynthetic process (GO:0032353)2.14673442
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.14116364
151renal absorption (GO:0070293)2.12946297
152embryonic retina morphogenesis in camera-type eye (GO:0060059)2.12713016
153regulation of actin filament-based movement (GO:1903115)2.11649235
154cyclic-nucleotide-mediated signaling (GO:0019935)2.11521084
155transcytosis (GO:0045056)2.10652825
156membrane assembly (GO:0071709)2.09882024
157metanephric epithelium development (GO:0072207)2.09193034
158cell volume homeostasis (GO:0006884)2.05426995
159positive regulation of sodium ion transport (GO:0010765)2.03683798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62277409
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.92660656
3GBX2_23144817_ChIP-Seq_PC3_Human2.73945107
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64046783
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46071344
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21121906
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21121906
8DROSHA_22980978_ChIP-Seq_HELA_Human2.19908000
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19109502
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18470220
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16154857
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.15392290
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12319110
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11456244
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.07534234
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04912553
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04303756
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.99725790
19* LXR_22158963_ChIP-Seq_LIVER_Mouse1.85373614
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84447808
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82150155
22REST_21632747_ChIP-Seq_MESCs_Mouse1.80287194
23AR_21572438_ChIP-Seq_LNCaP_Human1.77790477
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.74956083
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.72450832
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72285324
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67925671
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.65264001
29CTNNB1_20460455_ChIP-Seq_HCT116_Human1.63719413
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.62432606
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.62027694
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56352454
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52412479
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51798755
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.49950288
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48447666
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.44670601
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.44405133
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41524901
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40986763
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40103893
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38949344
43* PIAS1_25552417_ChIP-Seq_VCAP_Human1.37943211
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36744860
45RXR_22108803_ChIP-Seq_LS180_Human1.34332529
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33878332
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33743238
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.31088704
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30412757
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26871746
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26574111
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24872464
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24014974
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19387554
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19138990
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.16645004
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16525128
58AR_25329375_ChIP-Seq_VCAP_Human1.16356869
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15024296
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.14901867
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13900917
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13799965
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13545962
64BCAT_22108803_ChIP-Seq_LS180_Human1.12813617
65AR_19668381_ChIP-Seq_PC3_Human1.12677407
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.12463495
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11841002
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11500483
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.10994974
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10643310
71P300_19829295_ChIP-Seq_ESCs_Human1.10629465
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.10473785
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10208160
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.09860350
75* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09433076
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08723381
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08645263
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07192520
79SMAD4_21741376_ChIP-Seq_HESCs_Human1.06805643
80* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05748938
81* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05665277
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05146420
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05013863
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04729321
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04429883
86* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03904523
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.03590931
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03256662
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.03013044
90SOX2_20726797_ChIP-Seq_SW620_Human1.01849769
91* STAT3_23295773_ChIP-Seq_U87_Human1.01782428
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.01691475
93* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00402691
94CJUN_26792858_Chip-Seq_BT549_Human0.99721931
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99619011
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99546490
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98070556
98AHR_22903824_ChIP-Seq_MCF-7_Human0.97481438
99TAF15_26573619_Chip-Seq_HEK293_Human0.97345617
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96687493
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.96374643
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94793589
103SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94622650
104TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93672783
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92569817
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92515506
107SMAD_19615063_ChIP-ChIP_OVARY_Human0.92021704
108TP53_16413492_ChIP-PET_HCT116_Human0.91784774
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91511425
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91288685
111TP53_18474530_ChIP-ChIP_U2OS_Human0.90960756
112* EP300_21415370_ChIP-Seq_HL-1_Mouse0.90491011
113* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90135689
114* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90135689
115ZNF274_21170338_ChIP-Seq_K562_Hela0.87820757
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.87034925
117YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85554595
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84747334
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84652838
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84300747
121TCF4_23295773_ChIP-Seq_U87_Human0.84256711
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83662258
123TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83545337
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.83436717
125KDM2B_26808549_Chip-Seq_K562_Human0.83281456
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.82715720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.32243200
2MP0004859_abnormal_synaptic_plasticity4.05929195
3MP0002139_abnormal_hepatobiliary_system3.38074411
4MP0003300_gastrointestinal_ulcer2.91153250
5MP0009046_muscle_twitch2.83892793
6MP0003635_abnormal_synaptic_transmissio2.80922603
7MP0004885_abnormal_endolymph2.79431610
8MP0004270_analgesia2.71869714
9MP0005423_abnormal_somatic_nervous2.63531393
10MP0005332_abnormal_amino_acid2.63257131
11MP0010386_abnormal_urinary_bladder2.54259936
12MP0003690_abnormal_glial_cell2.48471243
13MP0009745_abnormal_behavioral_response2.47741501
14MP0002064_seizures2.34765898
15MP0004858_abnormal_nervous_system2.23533410
16MP0005085_abnormal_gallbladder_physiolo2.22257609
17MP0003868_abnormal_feces_composition2.20401668
18MP0005365_abnormal_bile_salt2.19028494
19MP0001486_abnormal_startle_reflex2.13963102
20MP0002063_abnormal_learning/memory/cond2.13643018
21MP0002822_catalepsy2.13629878
22MP0008875_abnormal_xenobiotic_pharmacok2.08878803
23MP0003329_amyloid_beta_deposits2.07798259
24MP0003880_abnormal_central_pattern2.03663102
25MP0000462_abnormal_digestive_system1.96770366
26* MP0004043_abnormal_pH_regulation1.89724395
27MP0004019_abnormal_vitamin_homeostasis1.89497005
28MP0002572_abnormal_emotion/affect_behav1.89272110
29MP0002272_abnormal_nervous_system1.84966857
30MP0009780_abnormal_chondrocyte_physiolo1.84847522
31MP0005248_abnormal_Harderian_gland1.84340033
32MP0001968_abnormal_touch/_nociception1.78688631
33MP0001440_abnormal_grooming_behavior1.78325919
34MP0002734_abnormal_mechanical_nocicepti1.73872004
35MP0003252_abnormal_bile_duct1.73161251
36MP0008569_lethality_at_weaning1.69924876
37MP0003633_abnormal_nervous_system1.66384230
38MP0002132_abnormal_respiratory_system1.65770981
39MP0005167_abnormal_blood-brain_barrier1.63071966
40MP0010329_abnormal_lipoprotein_level1.62614911
41MP0003878_abnormal_ear_physiology1.62091557
42MP0005377_hearing/vestibular/ear_phenot1.62091557
43MP0003195_calcinosis1.59401065
44MP0002067_abnormal_sensory_capabilities1.58612207
45MP0005257_abnormal_intraocular_pressure1.58333133
46MP0001501_abnormal_sleep_pattern1.57121655
47MP0005646_abnormal_pituitary_gland1.55702207
48MP0000613_abnormal_salivary_gland1.54453605
49MP0002736_abnormal_nociception_after1.45460038
50MP0002876_abnormal_thyroid_physiology1.43767540
51MP0005220_abnormal_exocrine_pancreas1.43724930
52MP0003045_fibrosis1.36453610
53* MP0001664_abnormal_digestion1.33465791
54MP0003075_altered_response_to1.31113684
55MP0005584_abnormal_enzyme/coenzyme_acti1.30297934
56MP0003631_nervous_system_phenotype1.29320551
57MP0000604_amyloidosis1.24350458
58MP0001984_abnormal_olfaction1.24066022
59MP0004142_abnormal_muscle_tone1.23655803
60MP0000566_synostosis1.23454593
61MP0002733_abnormal_thermal_nociception1.21942286
62MP0002163_abnormal_gland_morphology1.21632162
63MP0009384_cardiac_valve_regurgitation1.20739595
64MP0002089_abnormal_postnatal_growth/wei1.20479024
65MP0002557_abnormal_social/conspecific_i1.20186986
66MP0001485_abnormal_pinna_reflex1.19697438
67* MP0001765_abnormal_ion_homeostasis1.14794067
68MP0005535_abnormal_body_temperature1.11739606
69MP0004924_abnormal_behavior1.11728048
70MP0005386_behavior/neurological_phenoty1.11728048
71MP0002909_abnormal_adrenal_gland1.11117434
72MP0002928_abnormal_bile_duct1.11099035
73MP0001502_abnormal_circadian_rhythm1.11039455
74MP0002118_abnormal_lipid_homeostasis1.10878020
75MP0001970_abnormal_pain_threshold1.10528769
76MP0009643_abnormal_urine_homeostasis1.10194807
77MP0003183_abnormal_peptide_metabolism1.08839023
78MP0005379_endocrine/exocrine_gland_phen1.08578176
79MP0002277_abnormal_respiratory_mucosa1.07496527
80MP0002735_abnormal_chemical_nociception1.06965893
81MP0008872_abnormal_physiological_respon1.05169767
82MP0000920_abnormal_myelination1.04465476
83MP0003634_abnormal_glial_cell1.04035520
84MP0002066_abnormal_motor_capabilities/c1.03519279
85MP0003646_muscle_fatigue1.01069531
86MP0005595_abnormal_vascular_smooth0.98173049
87MP0001756_abnormal_urination0.98154084
88MP0000778_abnormal_nervous_system0.98125592
89MP0001177_atelectasis0.98006487
90MP0010352_gastrointestinal_tract_polyps0.97940344
91MP0003632_abnormal_nervous_system0.96273010
92MP0000026_abnormal_inner_ear0.95482234
93MP0004215_abnormal_myocardial_fiber0.94215644
94MP0001666_abnormal_nutrient_absorption0.93895966
95MP0005409_darkened_coat_color0.92770609
96MP0009840_abnormal_foam_cell0.91380532
97MP0008961_abnormal_basal_metabolism0.90559640
98MP0001958_emphysema0.90315305
99MP0002168_other_aberrant_phenotype0.89437861
100MP0004742_abnormal_vestibular_system0.88644021
101MP0001270_distended_abdomen0.88571462
102MP0005670_abnormal_white_adipose0.87738005
103MP0002138_abnormal_hepatobiliary_system0.87334707
104MP0003091_abnormal_cell_migration0.86448308
105MP0003879_abnormal_hair_cell0.86301897
106MP0000534_abnormal_ureter_morphology0.85869357
107MP0000955_abnormal_spinal_cord0.85386364
108MP0002229_neurodegeneration0.85350203
109MP0004272_abnormal_basement_membrane0.84760659
110MP0004130_abnormal_muscle_cell0.81589674
111MP0003137_abnormal_impulse_conducting0.81423263
112MP0000538_abnormal_urinary_bladder0.81186485
113MP0008874_decreased_physiological_sensi0.81088213
114MP0002882_abnormal_neuron_morphology0.79926997
115MP0002069_abnormal_eating/drinking_beha0.79847810
116MP0002254_reproductive_system_inflammat0.79838174
117MP0001963_abnormal_hearing_physiology0.78619752
118MP0003283_abnormal_digestive_organ0.77417409
119MP0002896_abnormal_bone_mineralization0.76222746
120MP0005083_abnormal_biliary_tract0.75539051
121MP0002184_abnormal_innervation0.74438855
122MP0005551_abnormal_eye_electrophysiolog0.74344677
123* MP0005636_abnormal_mineral_homeostasis0.74200774
124MP0003136_yellow_coat_color0.73391392
125MP0002102_abnormal_ear_morphology0.73246772
126MP0004085_abnormal_heartbeat0.72034161
127MP0000230_abnormal_systemic_arterial0.70533875
128MP0004811_abnormal_neuron_physiology0.69258092
129MP0005645_abnormal_hypothalamus_physiol0.68742639
130MP0002152_abnormal_brain_morphology0.68329840
131MP0005166_decreased_susceptibility_to0.67762318

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)5.21446673
2Metabolic alkalosis (HP:0200114)4.62150674
3Hypokalemic alkalosis (HP:0001949)4.26004530
4Focal motor seizures (HP:0011153)4.22116252
5Abnormal urine output (HP:0012590)3.97271211
6Gout (HP:0001997)3.95022042
7Hyperglycinuria (HP:0003108)3.88477325
8Myokymia (HP:0002411)3.72517299
9Hemiplegia (HP:0002301)3.66590287
10Polyuria (HP:0000103)3.59694917
11Abnormality of renal excretion (HP:0011036)3.59195972
12Confusion (HP:0001289)3.52617799
13Hypomagnesemia (HP:0002917)3.50868322
14Abnormality of glycine metabolism (HP:0010895)3.43579488
15Abnormality of serine family amino acid metabolism (HP:0010894)3.43579488
16Action tremor (HP:0002345)3.42378378
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.40080288
18Potter facies (HP:0002009)3.29749849
19Facial shape deformation (HP:0011334)3.29749849
20Polydipsia (HP:0001959)3.21217405
21Abnormal drinking behavior (HP:0030082)3.21217405
22Ketoacidosis (HP:0001993)3.18642695
23Status epilepticus (HP:0002133)3.16247281
24Focal seizures (HP:0007359)3.13275340
25Hemiparesis (HP:0001269)3.12138404
26Hyperactive renin-angiotensin system (HP:0000841)3.08605699
27Alkalosis (HP:0001948)3.03837999
28Diplopia (HP:0000651)3.03515488
29Abnormality of binocular vision (HP:0011514)3.03515488
30Dysdiadochokinesis (HP:0002075)2.96148671
31Ileus (HP:0002595)2.92856980
32Ketosis (HP:0001946)2.92659925
33Abnormal eating behavior (HP:0100738)2.90160747
34Aplasia of the phalanges of the hand (HP:0009802)2.88184938
35Aplasia involving bones of the extremities (HP:0009825)2.88184938
36Aplasia involving bones of the upper limbs (HP:0009823)2.88184938
37Obstructive sleep apnea (HP:0002870)2.87485003
38Progressive cerebellar ataxia (HP:0002073)2.84444465
39Decreased circulating renin level (HP:0003351)2.83179062
40Hyperglycinemia (HP:0002154)2.82838859
41Neonatal short-limb short stature (HP:0008921)2.82024911
42Abnormality of magnesium homeostasis (HP:0004921)2.81178322
43Abnormality of renin-angiotensin system (HP:0000847)2.79857543
44Glomerulonephritis (HP:0000099)2.79620391
45Tetraplegia (HP:0002445)2.77579130
46Exocrine pancreatic insufficiency (HP:0001738)2.75128484
47Hyperammonemia (HP:0001987)2.73947281
48Xanthomatosis (HP:0000991)2.73330777
49Alacrima (HP:0000522)2.73293435
50Hyperaldosteronism (HP:0000859)2.72838177
51Generalized tonic-clonic seizures (HP:0002069)2.71901639
52Rectal prolapse (HP:0002035)2.71708490
53Partial duplication of thumb phalanx (HP:0009944)2.67733167
54Intention tremor (HP:0002080)2.62676281
55Delayed CNS myelination (HP:0002188)2.62487465
56Hyperuricemia (HP:0002149)2.61901236
57Increased purine levels (HP:0004368)2.61901236
58Hyperventilation (HP:0002883)2.61129515
59Megalencephaly (HP:0001355)2.53842143
60Neurofibrillary tangles (HP:0002185)2.51736890
61Epileptic encephalopathy (HP:0200134)2.51518331
62Postural instability (HP:0002172)2.46732085
63Abnormality of purine metabolism (HP:0004352)2.44578026
64Adrenal overactivity (HP:0002717)2.44516819
65Hyperlipoproteinemia (HP:0010980)2.43098527
66Abnormality of chloride homeostasis (HP:0011422)2.42604697
67Proximal tubulopathy (HP:0000114)2.42518562
68Widely patent fontanelles and sutures (HP:0004492)2.40678266
69Bronchomalacia (HP:0002780)2.38669922
70Arterial tortuosity (HP:0005116)2.38592305
71Hydroxyprolinuria (HP:0003080)2.33880512
72Abnormality of proline metabolism (HP:0010907)2.33880512
73Hyperkalemia (HP:0002153)2.33630096
74Visual hallucinations (HP:0002367)2.33495322
75Partial duplication of the phalanx of hand (HP:0009999)2.32918590
76Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32696524
77Male infertility (HP:0003251)2.32051744
78Intrahepatic cholestasis (HP:0001406)2.29984295
79Renal salt wasting (HP:0000127)2.29398089
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28822132
81Bundle branch block (HP:0011710)2.28386685
82Scanning speech (HP:0002168)2.27891528
83Sensorimotor neuropathy (HP:0007141)2.23653244
84Hypoalphalipoproteinemia (HP:0003233)2.22121078
85Vascular tortuosity (HP:0004948)2.18592345
86Dysmetria (HP:0001310)2.15185661
87Abnormality of the right ventricle (HP:0001707)2.13233458
88Shallow orbits (HP:0000586)2.13133960
89Vascular calcification (HP:0004934)2.12679593
90Gaze-evoked nystagmus (HP:0000640)2.12678129
91Decreased lacrimation (HP:0000633)2.12552772
92Fat malabsorption (HP:0002630)2.10011749
93Deep venous thrombosis (HP:0002625)2.09988592
94Ankle clonus (HP:0011448)2.09952137
95Dysmetric saccades (HP:0000641)2.09945553
96Hypoglycemic coma (HP:0001325)2.09883097
97Supranuclear gaze palsy (HP:0000605)2.07979377
98Absence seizures (HP:0002121)2.06941028
99Mitral stenosis (HP:0001718)2.04919876
100Abnormality of sodium homeostasis (HP:0010931)2.04170612
101Papilledema (HP:0001085)2.01006193
102Cerebral inclusion bodies (HP:0100314)1.99611633
103Nephritis (HP:0000123)1.98998146
104Anxiety (HP:0000739)1.98169852
105Hypercalciuria (HP:0002150)1.97978491
106Febrile seizures (HP:0002373)1.97323387
107Vertebral arch anomaly (HP:0008438)1.96588863
108Impaired social interactions (HP:0000735)1.96013133
109Abnormal social behavior (HP:0012433)1.96013133
110Neoplasm of the heart (HP:0100544)1.95948752
111Enlarged kidneys (HP:0000105)1.95538221
112Thickened helices (HP:0000391)1.94679011
113Polyphagia (HP:0002591)1.94241304
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.94117687
115Dialeptic seizures (HP:0011146)1.91541666
116Hypokalemia (HP:0002900)1.90859038
117Sleep apnea (HP:0010535)1.89296790
118Depression (HP:0000716)1.87076107
119Cardiovascular calcification (HP:0011915)1.86805187
120Broad-based gait (HP:0002136)1.85239616
121Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.85127107
122Synostosis involving the elbow (HP:0003938)1.84910886
123Humeroradial synostosis (HP:0003041)1.84910886
124Atonic seizures (HP:0010819)1.84595020
125Broad metatarsal (HP:0001783)1.83609641
126Truncal ataxia (HP:0002078)1.81973040
127Mixed hearing impairment (HP:0000410)1.81428821
128Hyponatremia (HP:0002902)1.79837268
129Pheochromocytoma (HP:0002666)1.77794037
130Hypolipoproteinemia (HP:0010981)1.77726772
131Abnormality of fatty-acid metabolism (HP:0004359)1.77645094
132Flat acetabular roof (HP:0003180)1.77598621
133Torticollis (HP:0000473)1.76079515
134Impaired vibration sensation in the lower limbs (HP:0002166)1.75280325
135Turricephaly (HP:0000262)1.74495897
136Abnormality of potassium homeostasis (HP:0011042)1.74346563
137Congenital sensorineural hearing impairment (HP:0008527)1.70264347
138Visceral angiomatosis (HP:0100761)1.68508940
139Aortic aneurysm (HP:0004942)1.67967100
140Cubitus valgus (HP:0002967)1.65191661
141Abnormal biliary tract morphology (HP:0012440)1.64285583
142Split foot (HP:0001839)1.63734826
143Abnormality of permanent molar morphology (HP:0011071)1.63562074
144Abnormality of the dental root (HP:0006486)1.63562074
145Taurodontia (HP:0000679)1.63562074
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.63135812
147Abnormality of the middle phalanges of the toes (HP:0010183)1.60614804
148Syncope (HP:0001279)1.60383988
149Abnormality of molar (HP:0011077)1.59418209
150Abnormality of molar morphology (HP:0011070)1.59418209
151Abnormality of monocarboxylic acid metabolism (HP:0010996)1.58567618
152Polar cataract (HP:0010696)1.57792788
153Overgrowth (HP:0001548)1.56567149
154Hyperextensible skin (HP:0000974)1.55544133
155Abnormal pancreas size (HP:0012094)1.53852798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.41353235
2NTRK33.23938520
3OXSR12.96942038
4AKT32.86552198
5WNK42.77935792
6NTRK22.66638434
7WNK32.63436016
8TNIK2.60730596
9MAP3K92.16820296
10PRKD32.14485129
11MAP3K42.11714164
12LMTK22.04236587
13SGK2232.01524634
14SGK4942.01524634
15SGK21.92304909
16STK381.90175400
17MINK11.85656136
18MAP2K41.78874470
19SGK31.77405795
20PHKG21.68878143
21PHKG11.68878143
22MARK11.68666191
23STK391.64264878
24DAPK21.63784009
25NTRK11.60033229
26MAP2K71.59763665
27STK38L1.59621932
28CAMKK11.59531819
29PIK3CA1.59527826
30PRKG21.57181013
31PAK61.54529743
32WNK11.51585462
33PINK11.49735255
34RIPK11.37931251
35SIK11.36349612
36EPHA31.26079184
37CAMKK21.23553943
38KSR21.21702685
39PRKCG1.19067394
40CASK1.14870194
41CDK51.10201609
42INSRR1.09976750
43BCKDK1.09027108
44CAMK1G1.04968135
45PRKCH1.04788731
46MYLK1.03396528
47DMPK1.01978025
48TRIB31.00006747
49UHMK10.95643776
50MAP3K130.95436924
51MAPK150.93536211
52TYRO30.93532045
53PAK30.93460976
54SGK10.91413529
55MAP3K70.90908373
56RIPK40.89273035
57MAPK130.86334794
58FGFR20.85850037
59MAP3K20.84276986
60PDPK10.81276096
61CAMK2G0.80389378
62EPHA20.80284349
63TNK20.79014589
64KSR10.78748189
65CAMK2A0.76610139
66STK110.74654697
67MAPK120.73954518
68PDK40.73061162
69PDK30.73061162
70PDGFRB0.73019815
71CAMK1D0.72699844
72ERBB40.70271938
73PRPF4B0.69781071
74PDK10.69091751
75FES0.67718594
76RET0.67572346
77MET0.67204221
78CAMK10.66406727
79PRKAA20.65495192
80FRK0.65235504
81PRKAA10.64799771
82ACVR1B0.63846208
83PNCK0.62225222
84CAMK2B0.61598826
85NEK60.61309331
86PRKCZ0.60810149
87CDC42BPA0.60444458
88BMX0.57287337
89RPS6KA30.57051574
90CAMK40.56745500
91GRK50.55691974
92EPHB10.54787734
93PRKCE0.54009774
94LATS10.53922734
95FGFR30.52796947
96NEK10.52297515
97ICK0.52281637
98SIK20.51886533
99ROCK10.51784260
100PKN10.49256810
101PTK60.48142464
102* PRKACG0.47444807
103PRKD20.46966514
104PRKG10.46803707
105NEK90.46434369
106CSNK1A1L0.46144135
107CAMK2D0.45227976
108PDGFRA0.45181700
109MUSK0.44994558
110MARK20.44880918
111DYRK1A0.44819168
112* PRKCA0.44601387
113TAOK10.43997197
114MAPK100.43574904
115LATS20.43398298
116CDK150.43092681
117PKN20.42567263
118ERBB20.42300798
119BCR0.42297583
120FYN0.41860592
121TRPM70.40784562
122NLK0.40711894
123DDR20.40137573
124ROCK20.40031409
125CDK180.39908713
126PRKD10.38198005
127JAK10.38030774
128MAP2K10.37724912
129* PRKACA0.37672882
130MAPK70.36670807
131PTK20.36558460
132FER0.35807284
133STK240.35130870

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.09357761
2* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.08818591
3Butanoate metabolism_Homo sapiens_hsa006502.19873289
4Nicotine addiction_Homo sapiens_hsa050332.11036699
5Arginine biosynthesis_Homo sapiens_hsa002202.03458460
6Fatty acid degradation_Homo sapiens_hsa000712.01380824
7* Bile secretion_Homo sapiens_hsa049761.92766042
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83702648
9Fatty acid metabolism_Homo sapiens_hsa012121.82251397
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79150190
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.77535721
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76899313
13Propanoate metabolism_Homo sapiens_hsa006401.75335720
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73541513
15GABAergic synapse_Homo sapiens_hsa047271.73423583
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72715691
17Fatty acid biosynthesis_Homo sapiens_hsa000611.67461413
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65458854
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59732809
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53892211
21PPAR signaling pathway_Homo sapiens_hsa033201.53450437
22Glutamatergic synapse_Homo sapiens_hsa047241.48433065
23Gastric acid secretion_Homo sapiens_hsa049711.43934750
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43579919
25Salivary secretion_Homo sapiens_hsa049701.42596638
26Circadian rhythm_Homo sapiens_hsa047101.40808912
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35982169
28Tryptophan metabolism_Homo sapiens_hsa003801.30314691
29Peroxisome_Homo sapiens_hsa041461.28288703
30Circadian entrainment_Homo sapiens_hsa047131.26391337
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25936093
32Synaptic vesicle cycle_Homo sapiens_hsa047211.25764055
33Morphine addiction_Homo sapiens_hsa050321.20652050
34Insulin secretion_Homo sapiens_hsa049111.17475016
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13517534
36beta-Alanine metabolism_Homo sapiens_hsa004101.12382787
37Long-term potentiation_Homo sapiens_hsa047201.07231660
38Olfactory transduction_Homo sapiens_hsa047401.06359022
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05961614
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05714075
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03239801
42Mineral absorption_Homo sapiens_hsa049781.01832939
43Pyruvate metabolism_Homo sapiens_hsa006201.00758392
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.96434845
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95634747
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93204573
47Amphetamine addiction_Homo sapiens_hsa050310.91899715
48Vibrio cholerae infection_Homo sapiens_hsa051100.89704847
49Vitamin digestion and absorption_Homo sapiens_hsa049770.88916924
50Tight junction_Homo sapiens_hsa045300.87832786
51Taste transduction_Homo sapiens_hsa047420.87232162
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.86794086
53Thyroid hormone synthesis_Homo sapiens_hsa049180.85715450
54Renin secretion_Homo sapiens_hsa049240.84990431
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.82436167
56Vitamin B6 metabolism_Homo sapiens_hsa007500.82187334
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81569318
58Glycerolipid metabolism_Homo sapiens_hsa005610.80813739
59Sulfur metabolism_Homo sapiens_hsa009200.78217735
60Carbon metabolism_Homo sapiens_hsa012000.77952931
61Fat digestion and absorption_Homo sapiens_hsa049750.76352795
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74896114
63Starch and sucrose metabolism_Homo sapiens_hsa005000.73050795
64ECM-receptor interaction_Homo sapiens_hsa045120.73034127
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72726259
66Long-term depression_Homo sapiens_hsa047300.72073632
67Calcium signaling pathway_Homo sapiens_hsa040200.70953184
68Estrogen signaling pathway_Homo sapiens_hsa049150.70919424
69cAMP signaling pathway_Homo sapiens_hsa040240.70905230
70Cocaine addiction_Homo sapiens_hsa050300.69307141
71Dopaminergic synapse_Homo sapiens_hsa047280.68181980
72Tyrosine metabolism_Homo sapiens_hsa003500.64321715
73ABC transporters_Homo sapiens_hsa020100.63354230
74Dorso-ventral axis formation_Homo sapiens_hsa043200.62999303
75Cholinergic synapse_Homo sapiens_hsa047250.62852663
76Arginine and proline metabolism_Homo sapiens_hsa003300.62112264
77Complement and coagulation cascades_Homo sapiens_hsa046100.61499475
78Collecting duct acid secretion_Homo sapiens_hsa049660.60986078
79Dilated cardiomyopathy_Homo sapiens_hsa054140.60520592
80Lysine degradation_Homo sapiens_hsa003100.59348133
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59174849
82Biosynthesis of amino acids_Homo sapiens_hsa012300.58806421
83Fatty acid elongation_Homo sapiens_hsa000620.58704294
84Focal adhesion_Homo sapiens_hsa045100.58461191
85Renin-angiotensin system_Homo sapiens_hsa046140.57128711
86Glioma_Homo sapiens_hsa052140.56650188
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55662597
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55501180
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55486361
90* Pancreatic secretion_Homo sapiens_hsa049720.55381422
91Caffeine metabolism_Homo sapiens_hsa002320.54580493
92AMPK signaling pathway_Homo sapiens_hsa041520.53249366
93Type II diabetes mellitus_Homo sapiens_hsa049300.52996012
94Adherens junction_Homo sapiens_hsa045200.52501833
95Chemical carcinogenesis_Homo sapiens_hsa052040.52261894
96Gap junction_Homo sapiens_hsa045400.51511838
97Rap1 signaling pathway_Homo sapiens_hsa040150.51189632
98Histidine metabolism_Homo sapiens_hsa003400.50928473
99Prion diseases_Homo sapiens_hsa050200.50906048
100Cardiac muscle contraction_Homo sapiens_hsa042600.50794489
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.50725696
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48768450
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.48150814
104Phenylalanine metabolism_Homo sapiens_hsa003600.47667123
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47102389
106Oxytocin signaling pathway_Homo sapiens_hsa049210.46895970
107Steroid biosynthesis_Homo sapiens_hsa001000.45645503
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45159377
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.44721007
110GnRH signaling pathway_Homo sapiens_hsa049120.43564373
111Glucagon signaling pathway_Homo sapiens_hsa049220.43251442
112Serotonergic synapse_Homo sapiens_hsa047260.42050591
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.41229421
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41135995
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40699830
116Retinol metabolism_Homo sapiens_hsa008300.40522292
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39130886
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39115199
119Protein digestion and absorption_Homo sapiens_hsa049740.38467993
120Choline metabolism in cancer_Homo sapiens_hsa052310.36377071
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.35996324
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35802618
123Melanogenesis_Homo sapiens_hsa049160.33888931

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