SLC4A1AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)8.09595415
2male meiosis I (GO:0007141)7.15620266
3chromosome organization involved in meiosis (GO:0070192)6.35675540
4mitotic metaphase plate congression (GO:0007080)5.34158883
5synaptonemal complex organization (GO:0070193)5.27392677
6retinal cone cell development (GO:0046549)5.20445830
7monoubiquitinated protein deubiquitination (GO:0035520)4.89752535
8metaphase plate congression (GO:0051310)4.58691171
9protein K11-linked deubiquitination (GO:0035871)4.48917059
10regulation of RNA export from nucleus (GO:0046831)4.42888723
11DNA synthesis involved in DNA repair (GO:0000731)4.34960249
12mitotic sister chromatid cohesion (GO:0007064)4.21128272
13spindle checkpoint (GO:0031577)4.13811925
14regulation of rhodopsin mediated signaling pathway (GO:0022400)4.12055488
15nuclear pore complex assembly (GO:0051292)4.04949812
16nuclear pore organization (GO:0006999)4.01695624
17regulation of spindle organization (GO:0090224)3.97255531
18establishment of chromosome localization (GO:0051303)3.95246360
19piRNA metabolic process (GO:0034587)3.93755079
20mitotic chromosome condensation (GO:0007076)3.92181960
21meiotic cell cycle process (GO:1903046)3.91110269
22protein localization to kinetochore (GO:0034501)3.90030645
23kinetochore organization (GO:0051383)3.88629294
24attachment of spindle microtubules to kinetochore (GO:0008608)3.85800387
25spindle assembly checkpoint (GO:0071173)3.79499117
26mitotic spindle checkpoint (GO:0071174)3.79114146
27mitotic spindle assembly checkpoint (GO:0007094)3.78784516
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.78405065
29negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.72222828
30negative regulation of sister chromatid segregation (GO:0033046)3.72222828
31negative regulation of mitotic sister chromatid separation (GO:2000816)3.72222828
32negative regulation of mitotic sister chromatid segregation (GO:0033048)3.72222828
33negative regulation of chromosome segregation (GO:0051985)3.69570415
34rhodopsin mediated signaling pathway (GO:0016056)3.68666730
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.68425904
36regulation of mitotic spindle organization (GO:0060236)3.67416983
37histone H2A monoubiquitination (GO:0035518)3.67365222
38regulation of cilium movement (GO:0003352)3.67048832
39regulation of mitotic metaphase/anaphase transition (GO:0030071)3.65977065
40regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.63185027
41kynurenine metabolic process (GO:0070189)3.60898606
42mitotic sister chromatid segregation (GO:0000070)3.60379987
43protein localization to chromosome, centromeric region (GO:0071459)3.59572302
44viral mRNA export from host cell nucleus (GO:0046784)3.59444280
45negative regulation of histone methylation (GO:0031061)3.58584432
46meiotic chromosome segregation (GO:0045132)3.58511879
47snRNA transcription (GO:0009301)3.58226006
48resolution of meiotic recombination intermediates (GO:0000712)3.57338256
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53900978
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53235469
51indole-containing compound catabolic process (GO:0042436)3.52243186
52indolalkylamine catabolic process (GO:0046218)3.52243186
53tryptophan catabolic process (GO:0006569)3.52243186
54regulation of mitotic sister chromatid separation (GO:0010965)3.51874078
55regulation of mitotic sister chromatid segregation (GO:0033047)3.51874078
56regulation of sister chromatid segregation (GO:0033045)3.51874078
57regulation of DNA endoreduplication (GO:0032875)3.49067623
58regulation of chromosome segregation (GO:0051983)3.48513585
59chromatin remodeling at centromere (GO:0031055)3.43964461
60mitotic nuclear envelope disassembly (GO:0007077)3.43873362
61axoneme assembly (GO:0035082)3.41476289
62CENP-A containing nucleosome assembly (GO:0034080)3.40277043
63kinetochore assembly (GO:0051382)3.38984177
64ribosome assembly (GO:0042255)3.37419692
65sister chromatid cohesion (GO:0007062)3.36065848
66regulation of nucleobase-containing compound transport (GO:0032239)3.33505744
67regulation of centriole replication (GO:0046599)3.29255544
68proteasome assembly (GO:0043248)3.29076487
69indolalkylamine metabolic process (GO:0006586)3.28098386
70male meiosis (GO:0007140)3.26166264
71sister chromatid segregation (GO:0000819)3.24904410
72protein K63-linked deubiquitination (GO:0070536)3.24569407
73protein K6-linked ubiquitination (GO:0085020)3.24432451
74establishment of protein localization to Golgi (GO:0072600)3.23511766
75positive regulation of chromosome segregation (GO:0051984)3.22642143
76DNA replication-independent nucleosome organization (GO:0034724)3.22452371
77DNA replication-independent nucleosome assembly (GO:0006336)3.22452371
78nuclear envelope disassembly (GO:0051081)3.21698380
79membrane disassembly (GO:0030397)3.21698380
80histone exchange (GO:0043486)3.20992919
81centriole replication (GO:0007099)3.18318030
82signal peptide processing (GO:0006465)3.18022450
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17254246
84DNA replication checkpoint (GO:0000076)3.16828757
85positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16526525
86positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16526525
87positive regulation of mitotic sister chromatid separation (GO:1901970)3.16526525
88regulation of centrosome cycle (GO:0046605)3.16505515
89pore complex assembly (GO:0046931)3.14513281
90photoreceptor cell maintenance (GO:0045494)3.13685400
91negative regulation of DNA-dependent DNA replication (GO:2000104)3.12787803
92detection of light stimulus involved in visual perception (GO:0050908)3.09764978
93detection of light stimulus involved in sensory perception (GO:0050962)3.09764978
94behavioral response to nicotine (GO:0035095)3.09044948
95DNA methylation involved in gamete generation (GO:0043046)3.07954574
96chromosome segregation (GO:0007059)3.07442660
97nonmotile primary cilium assembly (GO:0035058)3.05400823
98histone H2A ubiquitination (GO:0033522)3.04325849
99tryptophan metabolic process (GO:0006568)3.01992142
100protein-cofactor linkage (GO:0018065)3.01720605
101replication fork processing (GO:0031297)3.01394725
102regulation of histone H3-K27 methylation (GO:0061085)3.00512928
103DNA methylation (GO:0006306)2.99284664
104DNA alkylation (GO:0006305)2.99284664
105positive regulation of meiosis (GO:0045836)2.95484315
106chromatin assembly or disassembly (GO:0006333)2.94384671
107RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93480805
108cilium morphogenesis (GO:0060271)2.91826503
109regulation of meiosis I (GO:0060631)2.89273667
110eye photoreceptor cell development (GO:0042462)2.88686056
111photoreceptor cell development (GO:0042461)2.88146901
112pyrimidine dimer repair (GO:0006290)2.88017270
113auditory receptor cell stereocilium organization (GO:0060088)2.87955321
114meiotic nuclear division (GO:0007126)2.87795488
115regulation of DNA damage checkpoint (GO:2000001)2.86744904
116maturation of 5.8S rRNA (GO:0000460)2.85476763
117negative regulation of meiosis (GO:0045835)2.85437940
118meiotic cell cycle (GO:0051321)2.84715251
119regulation of microtubule-based movement (GO:0060632)2.84392501
120reciprocal meiotic recombination (GO:0007131)2.84304335
121reciprocal DNA recombination (GO:0035825)2.84304335
122rRNA catabolic process (GO:0016075)2.83709065
123positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.83606623
124oxidative demethylation (GO:0070989)2.83104960
125glycerophospholipid catabolic process (GO:0046475)2.82293594
126negative regulation of response to food (GO:0032096)2.82211527
127negative regulation of appetite (GO:0032099)2.82211527
128regulation of spindle checkpoint (GO:0090231)2.82117822
129negative regulation of mitosis (GO:0045839)2.80571513
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78873234
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.78873234
132NADH dehydrogenase complex assembly (GO:0010257)2.78873234
133negative regulation of nuclear division (GO:0051784)2.77241576
134gene silencing by RNA (GO:0031047)2.76991370
135protein localization to cilium (GO:0061512)2.76866474
136synaptonemal complex assembly (GO:0007130)2.76680081
137DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.76504982
138positive regulation of guanylate cyclase activity (GO:0031284)2.75042506
139protein complex biogenesis (GO:0070271)2.74893786
140cellular ketone body metabolic process (GO:0046950)2.73681360
141microtubule depolymerization (GO:0007019)2.73150393
142protein K48-linked deubiquitination (GO:0071108)2.72712889
143meiosis I (GO:0007127)2.72661912
144positive regulation of meiotic cell cycle (GO:0051446)2.72309604
145mismatch repair (GO:0006298)2.71204953
146inner ear receptor stereocilium organization (GO:0060122)2.69745826
147negative regulation of macrophage differentiation (GO:0045650)2.69396457
148DNA methylation or demethylation (GO:0044728)2.69184037
149regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68333305
150regulation of mitotic spindle checkpoint (GO:1903504)2.68333305
151DNA double-strand break processing (GO:0000729)2.68136759
152negative regulation of chromosome organization (GO:2001251)2.68013149
153double-strand break repair via homologous recombination (GO:0000724)2.67570790
154histone H2A acetylation (GO:0043968)2.66656598
155protein targeting to Golgi (GO:0000042)2.64960727
156recombinational repair (GO:0000725)2.64402874
157microtubule anchoring (GO:0034453)2.62384618
158benzene-containing compound metabolic process (GO:0042537)2.59899769
159neural tube formation (GO:0001841)2.57873098
160intraciliary transport (GO:0042073)2.57023256
161regulation of hexokinase activity (GO:1903299)2.56744350
162regulation of glucokinase activity (GO:0033131)2.56744350
163amino acid salvage (GO:0043102)2.56031271
164L-methionine salvage (GO:0071267)2.56031271
165L-methionine biosynthetic process (GO:0071265)2.56031271
166ketone body metabolic process (GO:1902224)2.54646516
167mannosylation (GO:0097502)2.53287140
168respiratory chain complex IV assembly (GO:0008535)2.51374638
169xenobiotic catabolic process (GO:0042178)2.49463177
170mitochondrial respiratory chain complex assembly (GO:0033108)2.48809665
171sex differentiation (GO:0007548)2.47497795
172cilium or flagellum-dependent cell motility (GO:0001539)2.44826433
173dopamine transport (GO:0015872)2.44521280
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43878206
175indole-containing compound metabolic process (GO:0042430)2.43592856
176prenylation (GO:0097354)2.39421157
177protein prenylation (GO:0018342)2.39421157
178cilium organization (GO:0044782)2.37678365
179transmission of nerve impulse (GO:0019226)2.35319185
180neuronal action potential propagation (GO:0019227)2.34896489
181brain morphogenesis (GO:0048854)2.34498250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.47096770
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.76858940
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.38929327
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.62216220
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.29816350
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09230539
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.03487589
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.91225452
9GBX2_23144817_ChIP-Seq_PC3_Human2.88891635
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65431961
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.59331798
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.56113446
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32265024
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.31107097
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.26645767
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23624090
17TAF15_26573619_Chip-Seq_HEK293_Human2.03869452
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03076300
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02819791
20ER_23166858_ChIP-Seq_MCF-7_Human1.92589597
21P300_19829295_ChIP-Seq_ESCs_Human1.92564817
22AR_21909140_ChIP-Seq_LNCAP_Human1.90878297
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88871574
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86339290
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.85847256
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83965848
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83798041
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82492025
29VDR_23849224_ChIP-Seq_CD4+_Human1.78354434
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78148738
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77963989
32EZH2_22144423_ChIP-Seq_EOC_Human1.73209748
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70476583
34STAT3_23295773_ChIP-Seq_U87_Human1.67213156
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64950109
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64089865
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.63201912
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61350516
39MYC_22102868_ChIP-Seq_BL_Human1.60830944
40VDR_22108803_ChIP-Seq_LS180_Human1.60591076
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59077594
42TP53_22573176_ChIP-Seq_HFKS_Human1.56263826
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55488025
44* TCF4_23295773_ChIP-Seq_U87_Human1.55173045
45SMAD4_21799915_ChIP-Seq_A2780_Human1.54332430
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52401948
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51029947
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50068305
49CBP_20019798_ChIP-Seq_JUKART_Human1.50068305
50* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46084575
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44554235
52SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43969722
53BCAT_22108803_ChIP-Seq_LS180_Human1.43789626
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41772198
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39497165
56KDM5A_27292631_Chip-Seq_BREAST_Human1.38545522
57* DCP1A_22483619_ChIP-Seq_HELA_Human1.38235892
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37555963
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35531135
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34426359
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33524067
62AR_25329375_ChIP-Seq_VCAP_Human1.33115702
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.32793776
64SOX2_19829295_ChIP-Seq_ESCs_Human1.31033110
65NANOG_19829295_ChIP-Seq_ESCs_Human1.31033110
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30812562
67* GABP_19822575_ChIP-Seq_HepG2_Human1.29793383
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29229800
69CIITA_25753668_ChIP-Seq_RAJI_Human1.28655642
70TCF4_22108803_ChIP-Seq_LS180_Human1.28491801
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28313648
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27634471
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27512816
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27407719
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27295408
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27272125
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27204291
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.26583858
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25116738
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25009483
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.24848324
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.24156820
83* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23740062
84P53_22387025_ChIP-Seq_ESCs_Mouse1.23403796
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22410553
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.22010074
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21804265
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21119015
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.21119015
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20875035
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.19592187
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.19394243
93EWS_26573619_Chip-Seq_HEK293_Human1.19371808
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18824190
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18243671
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.18020988
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17670083
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.17256900
99FOXP3_21729870_ChIP-Seq_TREG_Human1.17231910
100* ELK1_19687146_ChIP-ChIP_HELA_Human1.17050517
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.16853314
102RNF2_27304074_Chip-Seq_NSC_Mouse1.16722330
103RUNX2_22187159_ChIP-Seq_PCA_Human1.15574096
104CDX2_22108803_ChIP-Seq_LS180_Human1.15405948
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14856637
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13834694
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13344948
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12808702
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12386884
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11996125
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.11669968
112P300_18555785_Chip-Seq_ESCs_Mouse1.11619320
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11576931
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11383553
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11361605
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11235737
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.09893429
118TFEB_21752829_ChIP-Seq_HELA_Human1.08451358
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.07414091
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06476214
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06112710
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.04975051
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04407500
124XRN2_22483619_ChIP-Seq_HELA_Human1.04233628
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03534150
126IRF1_19129219_ChIP-ChIP_H3396_Human1.03421983
127MYC_18940864_ChIP-ChIP_HL60_Human1.03148140
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02806052
129NMYC_18555785_Chip-Seq_ESCs_Mouse1.02271693
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02201517
131AR_20517297_ChIP-Seq_VCAP_Human1.02099385
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00980238
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00478354
134SMAD_19615063_ChIP-ChIP_OVARY_Human0.99338410
135FUS_26573619_Chip-Seq_HEK293_Human0.99210722
136KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98418794
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98014196
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95223964
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.91932479
140* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88429091
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87644708
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.86196396
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85921261
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85190075
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82284607
146SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81779628
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81496056
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.81330696
149DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81247857
150IGF1R_20145208_ChIP-Seq_DFB_Human0.78563652
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.76795463
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76403889
153FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.76384439
154ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74889906
155* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74290021
156* BRD4_25478319_ChIP-Seq_HGPS_Human0.73308302
157PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72748620
158ZNF274_21170338_ChIP-Seq_K562_Hela0.71949695
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71689390
160HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71628537
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.70967053
162SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.70496477
163LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70006035
164CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69560260
165SOX2_18555785_ChIP-Seq_MESCs_Mouse0.68839112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.38746226
2MP0003111_abnormal_nucleus_morphology4.35805587
3MP0010094_abnormal_chromosome_stability4.10170129
4MP0008877_abnormal_DNA_methylation3.76323239
5MP0008058_abnormal_DNA_repair3.70825072
6MP0003077_abnormal_cell_cycle3.35489200
7MP0010307_abnormal_tumor_latency3.18548267
8MP0001986_abnormal_taste_sensitivity3.16838535
9MP0008057_abnormal_DNA_replication3.12329974
10MP0003195_calcinosis2.97439649
11MP0004957_abnormal_blastocyst_morpholog2.84426070
12MP0008007_abnormal_cellular_replicative2.81174963
13MP0005551_abnormal_eye_electrophysiolog2.64333865
14MP0000372_irregular_coat_pigmentation2.40920368
15MP0009046_muscle_twitch2.24572112
16MP0005253_abnormal_eye_physiology2.19824598
17MP0006072_abnormal_retinal_apoptosis2.12875270
18MP0002102_abnormal_ear_morphology2.12576314
19MP0003786_premature_aging2.06813307
20MP0008932_abnormal_embryonic_tissue2.05104162
21MP0003123_paternal_imprinting2.04832816
22MP0001984_abnormal_olfaction2.01561213
23MP0003718_maternal_effect2.00522722
24MP0002160_abnormal_reproductive_system1.96769568
25MP0003646_muscle_fatigue1.92269269
26MP0002876_abnormal_thyroid_physiology1.84692116
27MP0005646_abnormal_pituitary_gland1.82871856
28MP0001730_embryonic_growth_arrest1.77102515
29MP0006276_abnormal_autonomic_nervous1.76810253
30MP0000350_abnormal_cell_proliferation1.75844064
31MP0002638_abnormal_pupillary_reflex1.75621468
32MP0003121_genomic_imprinting1.75299140
33MP0002210_abnormal_sex_determination1.73474089
34MP0002138_abnormal_hepatobiliary_system1.73130257
35MP0000427_abnormal_hair_cycle1.70088734
36MP0003787_abnormal_imprinting1.66927397
37MP0009745_abnormal_behavioral_response1.65064889
38MP0005084_abnormal_gallbladder_morpholo1.55914991
39MP0001968_abnormal_touch/_nociception1.55746892
40MP0002396_abnormal_hematopoietic_system1.55185297
41MP0000383_abnormal_hair_follicle1.54176948
42MP0008875_abnormal_xenobiotic_pharmacok1.52474480
43MP0002837_dystrophic_cardiac_calcinosis1.51287320
44MP0001672_abnormal_embryogenesis/_devel1.51255340
45MP0005380_embryogenesis_phenotype1.51255340
46MP0005645_abnormal_hypothalamus_physiol1.47660952
47MP0003880_abnormal_central_pattern1.47654808
48MP0001929_abnormal_gametogenesis1.46369710
49MP0003950_abnormal_plasma_membrane1.45581010
50MP0001486_abnormal_startle_reflex1.45220717
51MP0005410_abnormal_fertilization1.44875622
52MP0004043_abnormal_pH_regulation1.42034328
53MP0004142_abnormal_muscle_tone1.41980947
54MP0001529_abnormal_vocalization1.41417696
55MP0001501_abnormal_sleep_pattern1.37880313
56MP0004808_abnormal_hematopoietic_stem1.37467275
57MP0003984_embryonic_growth_retardation1.35915167
58MP0002272_abnormal_nervous_system1.35347190
59MP0005076_abnormal_cell_differentiation1.34918594
60MP0002736_abnormal_nociception_after1.34663395
61MP0002088_abnormal_embryonic_growth/wei1.31622709
62MP0002085_abnormal_embryonic_tissue1.29694660
63MP0000653_abnormal_sex_gland1.29427898
64MP0000647_abnormal_sebaceous_gland1.29355959
65MP0001697_abnormal_embryo_size1.29246304
66MP0003136_yellow_coat_color1.28952960
67MP0001119_abnormal_female_reproductive1.28810316
68MP0004147_increased_porphyrin_level1.28171184
69MP0006035_abnormal_mitochondrial_morpho1.27018988
70MP0001145_abnormal_male_reproductive1.26776847
71MP0002064_seizures1.25633212
72MP0005187_abnormal_penis_morphology1.24395339
73MP0003303_peritoneal_inflammation1.23946807
74MP0005310_abnormal_salivary_gland1.22238328
75MP0002928_abnormal_bile_duct1.19258176
76MP0005391_vision/eye_phenotype1.17521972
77MP0002084_abnormal_developmental_patter1.14645377
78MP0006292_abnormal_olfactory_placode1.13209861
79MP0004215_abnormal_myocardial_fiber1.11241207
80MP0002877_abnormal_melanocyte_morpholog1.11085635
81MP0008872_abnormal_physiological_respon1.09353806
82MP0001835_abnormal_antigen_presentation1.09141313
83MP0003699_abnormal_female_reproductive1.06469808
84MP0010352_gastrointestinal_tract_polyps1.06208813
85MP0002080_prenatal_lethality1.06123132
86MP0000313_abnormal_cell_death1.05903058
87MP0005386_behavior/neurological_phenoty1.04334537
88MP0004924_abnormal_behavior1.04334537
89MP0002163_abnormal_gland_morphology1.03981001
90MP0001188_hyperpigmentation1.03430615
91MP0005195_abnormal_posterior_eye1.03075538
92MP0006036_abnormal_mitochondrial_physio1.02930087
93MP0002229_neurodegeneration1.02896267
94MP0001919_abnormal_reproductive_system1.02285970
95MP0005423_abnormal_somatic_nervous1.00802245
96MP0002572_abnormal_emotion/affect_behav1.00564133
97MP0003890_abnormal_embryonic-extraembry1.00088425
98MP0006054_spinal_hemorrhage0.99783902
99MP0002019_abnormal_tumor_incidence0.99082391
100MP0009672_abnormal_birth_weight0.98631041
101MP0002086_abnormal_extraembryonic_tissu0.98547556
102MP0010678_abnormal_skin_adnexa0.98347966
103MP0010386_abnormal_urinary_bladder0.98274067
104MP0000703_abnormal_thymus_morphology0.97800342
105MP0002067_abnormal_sensory_capabilities0.97471286
106MP0002938_white_spotting0.96301570
107MP0009703_decreased_birth_body0.94580366
108MP0002127_abnormal_cardiovascular_syste0.93930356
109MP0001764_abnormal_homeostasis0.93885235
110MP0001485_abnormal_pinna_reflex0.92079127
111MP0002090_abnormal_vision0.91041467
112MP0000631_abnormal_neuroendocrine_gland0.90878362
113MP0000767_abnormal_smooth_muscle0.90239018
114MP0008995_early_reproductive_senescence0.90179712
115MP0002095_abnormal_skin_pigmentation0.90090339
116MP0001915_intracranial_hemorrhage0.89632606
117MP0003937_abnormal_limbs/digits/tail_de0.89050228
118MP0005174_abnormal_tail_pigmentation0.88932049
119MP0000569_abnormal_digit_pigmentation0.87994053
120MP0000003_abnormal_adipose_tissue0.87583155
121MP0004742_abnormal_vestibular_system0.85702775
122MP0001970_abnormal_pain_threshold0.85237972
123MP0000358_abnormal_cell_content/0.84230301
124MP0009333_abnormal_splenocyte_physiolog0.83413529
125MP0002161_abnormal_fertility/fecundity0.81849914
126MP0000733_abnormal_muscle_development0.81824650
127MP0005377_hearing/vestibular/ear_phenot0.81134753
128MP0003878_abnormal_ear_physiology0.81134753
129MP0002735_abnormal_chemical_nociception0.80345295
130MP0009697_abnormal_copulation0.79122132
131MP0001800_abnormal_humoral_immune0.78882664
132MP0003698_abnormal_male_reproductive0.78838828
133MP0003635_abnormal_synaptic_transmissio0.78286384
134MP0003221_abnormal_cardiomyocyte_apopto0.76834532
135MP0005621_abnormal_cell_physiology0.75896388
136MP0001661_extended_life_span0.75523344
137MP0001324_abnormal_eye_pigmentation0.75518140
138MP0003186_abnormal_redox_activity0.74452535
139MP0002398_abnormal_bone_marrow0.73756795
140MP0005395_other_phenotype0.73738372
141MP0002653_abnormal_ependyma_morphology0.73493165
142MP0002557_abnormal_social/conspecific_i0.73445384
143MP0005389_reproductive_system_phenotype0.73259605
144MP0002693_abnormal_pancreas_physiology0.73049583
145MP0002452_abnormal_antigen_presenting0.72899261
146MP0005397_hematopoietic_system_phenotyp0.71967230
147MP0001545_abnormal_hematopoietic_system0.71967230
148MP0000428_abnormal_craniofacial_morphol0.71473470
149MP0003183_abnormal_peptide_metabolism0.71206755
150MP0005167_abnormal_blood-brain_barrier0.70759827
151MP0000015_abnormal_ear_pigmentation0.70709812
152MP0008789_abnormal_olfactory_epithelium0.70046668
153MP0004085_abnormal_heartbeat0.69762056
154MP0000689_abnormal_spleen_morphology0.69573897
155MP0005647_abnormal_sex_gland0.69501800
156MP0003633_abnormal_nervous_system0.69164097
157MP0003011_delayed_dark_adaptation0.68571991
158MP0001905_abnormal_dopamine_level0.68489581
159MP0004197_abnormal_fetal_growth/weight/0.68028919
160MP0000432_abnormal_head_morphology0.66957978
161MP0005384_cellular_phenotype0.65195946
162MP0004233_abnormal_muscle_weight0.65138158
163MP0002722_abnormal_immune_system0.64877886
164MP0002723_abnormal_immune_serum0.63746940
165MP0003941_abnormal_skin_development0.63649001
166MP0005671_abnormal_response_to0.61389789
167MP0001286_abnormal_eye_development0.60894918
168MP0004510_myositis0.60654546

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.50406307
2Chromsome breakage (HP:0040012)4.34112966
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08156160
4Birth length less than 3rd percentile (HP:0003561)3.52178862
5Molar tooth sign on MRI (HP:0002419)3.49115297
6Abnormality of midbrain morphology (HP:0002418)3.49115297
7Pigmentary retinal degeneration (HP:0001146)3.32812204
8Abnormality of the renal cortex (HP:0011035)3.25285819
9Bony spicule pigmentary retinopathy (HP:0007737)3.24293592
10Type II lissencephaly (HP:0007260)3.06759733
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.06625832
12Abnormality of alanine metabolism (HP:0010916)3.06625832
13Hyperalaninemia (HP:0003348)3.06625832
14Entropion (HP:0000621)3.06363111
15Impulsivity (HP:0100710)3.04528313
16Nephrogenic diabetes insipidus (HP:0009806)3.03393240
17Abnormality of chromosome stability (HP:0003220)2.96440203
18Renal cortical cysts (HP:0000803)2.96427292
19Hyperventilation (HP:0002883)2.92562246
20Abnormality of the labia minora (HP:0012880)2.92271768
21Volvulus (HP:0002580)2.87937645
22Attenuation of retinal blood vessels (HP:0007843)2.87389709
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.71349541
24Gaze-evoked nystagmus (HP:0000640)2.69677991
25Abnormal rod and cone electroretinograms (HP:0008323)2.65849766
26Oligodactyly (hands) (HP:0001180)2.65834590
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.65470949
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.65470949
29Patellar aplasia (HP:0006443)2.64939247
30Meckel diverticulum (HP:0002245)2.63881616
31Abnormality of the ileum (HP:0001549)2.60428630
32Abnormality of the fingertips (HP:0001211)2.60089552
33Abnormality of the renal medulla (HP:0100957)2.57456172
34Abnormal protein glycosylation (HP:0012346)2.54470133
35Abnormal glycosylation (HP:0012345)2.54470133
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54470133
37Abnormal protein N-linked glycosylation (HP:0012347)2.54470133
38Abnormality of the preputium (HP:0100587)2.51399972
39Azoospermia (HP:0000027)2.49863026
40Febrile seizures (HP:0002373)2.46862113
41Type II diabetes mellitus (HP:0005978)2.45238602
42True hermaphroditism (HP:0010459)2.43740025
43Abnormality of DNA repair (HP:0003254)2.43580249
44Decreased central vision (HP:0007663)2.42751719
45Pelvic girdle muscle weakness (HP:0003749)2.41063440
46Prostate neoplasm (HP:0100787)2.39458383
47Type I transferrin isoform profile (HP:0003642)2.38659835
48Genital tract atresia (HP:0001827)2.38612390
49Increased CSF lactate (HP:0002490)2.35778682
50Aplasia/Hypoplasia of the patella (HP:0006498)2.30940939
51Photophobia (HP:0000613)2.30457465
52Hypothermia (HP:0002045)2.28735277
53Ectopic kidney (HP:0000086)2.28205523
54Cystic liver disease (HP:0006706)2.27810497
55Chronic hepatic failure (HP:0100626)2.27500437
56Cerebellar dysplasia (HP:0007033)2.27406104
57Biliary tract neoplasm (HP:0100574)2.27139551
58Abolished electroretinogram (ERG) (HP:0000550)2.25425308
59Oligodactyly (HP:0012165)2.21380528
60Vaginal atresia (HP:0000148)2.21066669
61Abnormality of homocysteine metabolism (HP:0010919)2.17584187
62Homocystinuria (HP:0002156)2.17584187
63Lissencephaly (HP:0001339)2.17544265
64Urethral obstruction (HP:0000796)2.17451232
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16537872
66Prominent nose (HP:0000448)2.14895610
67Flat capital femoral epiphysis (HP:0003370)2.14457386
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.14388239
69Absent speech (HP:0001344)2.14172987
70Central scotoma (HP:0000603)2.13357441
71Abnormality of chromosome segregation (HP:0002916)2.13354258
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11440130
73Increased serum lactate (HP:0002151)2.11326132
74Hepatic necrosis (HP:0002605)2.10913927
75Overlapping toe (HP:0001845)2.09264801
76Inability to walk (HP:0002540)2.08519086
77Clumsiness (HP:0002312)2.04980385
78Agnosia (HP:0010524)2.04226598
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.03516195
80Progressive inability to walk (HP:0002505)2.01958724
81Pancreatic fibrosis (HP:0100732)2.01503276
82Clubbing of toes (HP:0100760)2.01352362
83Sclerocornea (HP:0000647)2.01042372
84Acute necrotizing encephalopathy (HP:0006965)1.99656918
85Absent radius (HP:0003974)1.98917476
86Stomach cancer (HP:0012126)1.97984081
87Retinal dysplasia (HP:0007973)1.97951703
88Focal seizures (HP:0007359)1.97805694
89Absent forearm bone (HP:0003953)1.97143525
90Aplasia involving forearm bones (HP:0009822)1.97143525
91Intestinal atresia (HP:0011100)1.96126325
92Methylmalonic acidemia (HP:0002912)1.96059414
93Abnormality of the musculature of the pelvis (HP:0001469)1.95915916
94Abnormality of the hip-girdle musculature (HP:0001445)1.95915916
953-Methylglutaconic aciduria (HP:0003535)1.95790821
96Shoulder girdle muscle weakness (HP:0003547)1.95617305
97Spontaneous abortion (HP:0005268)1.95335279
98Hepatocellular necrosis (HP:0001404)1.95005620
99Abnormality of the corticospinal tract (HP:0002492)1.94891889
100Fair hair (HP:0002286)1.94697232
101Myelodysplasia (HP:0002863)1.94658724
102Male pseudohermaphroditism (HP:0000037)1.94610080
103Ketoacidosis (HP:0001993)1.94515964
104Medulloblastoma (HP:0002885)1.93743567
105Focal motor seizures (HP:0011153)1.93625042
106Sloping forehead (HP:0000340)1.93553076
107Gonadotropin excess (HP:0000837)1.92520764
108Duodenal stenosis (HP:0100867)1.92517515
109Small intestinal stenosis (HP:0012848)1.92517515
110Astigmatism (HP:0000483)1.92279774
111Acute myeloid leukemia (HP:0004808)1.92180384
112Facial hemangioma (HP:0000329)1.89591719
113Metaphyseal dysplasia (HP:0100255)1.88057489
114Nephroblastoma (Wilms tumor) (HP:0002667)1.87707237
115Abnormality of the metopic suture (HP:0005556)1.87469047
116Dialeptic seizures (HP:0011146)1.86432596
117Prominent metopic ridge (HP:0005487)1.86323702
118Mitochondrial inheritance (HP:0001427)1.85452886
119Methylmalonic aciduria (HP:0012120)1.84958160
120Congenital hepatic fibrosis (HP:0002612)1.84601316
121Long eyelashes (HP:0000527)1.84383216
122Progressive macrocephaly (HP:0004481)1.83733487
123Papillary thyroid carcinoma (HP:0002895)1.82820896
124Protruding tongue (HP:0010808)1.81607818
125Progressive cerebellar ataxia (HP:0002073)1.81398097
126Widely spaced teeth (HP:0000687)1.80826756
127Abnormality of the duodenum (HP:0002246)1.79968755
128Abnormality of the carotid arteries (HP:0005344)1.78945914
129CNS demyelination (HP:0007305)1.78374369
130Ketosis (HP:0001946)1.77840522
131Pendular nystagmus (HP:0012043)1.77837707
132Hypoglycemic seizures (HP:0002173)1.77467265
133Scotoma (HP:0000575)1.76910913
134Acute encephalopathy (HP:0006846)1.76873103
135Abnormality of macular pigmentation (HP:0008002)1.76702628
136Horizontal nystagmus (HP:0000666)1.76147150
137Breast hypoplasia (HP:0003187)1.75702093
138Preaxial hand polydactyly (HP:0001177)1.75281503
139Medial flaring of the eyebrow (HP:0010747)1.74516544
140Cafe-au-lait spot (HP:0000957)1.74119612
141Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73540430
142Short nail (HP:0001799)1.73022058
143Tubulointerstitial nephritis (HP:0001970)1.71874362
144Abnormal biliary tract physiology (HP:0012439)1.71866893
145Bile duct proliferation (HP:0001408)1.71866893
146Poor coordination (HP:0002370)1.71183436
147Slender long bone (HP:0003100)1.70195640
148Retinitis pigmentosa (HP:0000510)1.70149473
149Embryonal renal neoplasm (HP:0011794)1.69479769
150Genetic anticipation (HP:0003743)1.68734841
151Bone marrow hypocellularity (HP:0005528)1.68467731
152Blepharitis (HP:0000498)1.67078329
153Mediastinal lymphadenopathy (HP:0100721)1.63214715
154Anal stenosis (HP:0002025)1.62504154
155Truncal obesity (HP:0001956)1.62167760
156Heterotopia (HP:0002282)1.60536798
157Deep philtrum (HP:0002002)1.59642113
158Congenital primary aphakia (HP:0007707)1.59525784
159Nephronophthisis (HP:0000090)1.59443517
160Abnormal spermatogenesis (HP:0008669)1.59366333
161Rough bone trabeculation (HP:0100670)1.58226253
162Abnormality of abdominal situs (HP:0011620)1.58045733
163Abdominal situs inversus (HP:0003363)1.58045733
164Supernumerary spleens (HP:0009799)1.56840797
165Pancreatic cysts (HP:0001737)1.56576900
166Abnormal biliary tract morphology (HP:0012440)1.55686495
167Sparse lateral eyebrow (HP:0005338)1.55064094
168Capillary hemangiomas (HP:0005306)1.54869831
169Male infertility (HP:0003251)1.52011992
170Flared metaphyses (HP:0003015)1.51002672
171Gait imbalance (HP:0002141)1.50212487
172Rhabdomyosarcoma (HP:0002859)1.50211264
173Transitional cell carcinoma of the bladder (HP:0006740)1.50128764
174Submucous cleft hard palate (HP:0000176)1.49816973
175Small epiphyses (HP:0010585)1.49182060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.86042830
2NEK23.79883683
3MKNK23.56466014
4PASK3.27061367
5PLK42.88347146
6PDK22.56670505
7TTK2.43676810
8CDK122.42610785
9ADRBK22.36964889
10MAP4K22.32970487
11BUB12.29364990
12CCNB12.22557380
13WEE12.15532343
14MKNK12.14214776
15WNK32.11653401
16NEK12.09692040
17BMPR1B2.05409863
18PLK12.02127537
19TRIM282.02041729
20MST41.96761939
21STK38L1.91839240
22CHEK21.87446872
23LATS11.85667487
24RPS6KA41.83586273
25BRSK21.77480184
26PLK31.76528643
27BRAF1.73460133
28MAP3K41.61984212
29STK31.61117314
30OXSR11.60039746
31AKT31.57459527
32SCYL21.56948989
33MARK31.47272279
34ZAK1.46891589
35MAPK131.41981123
36CDK31.41746699
37PTK2B1.40999194
38BCR1.39362230
39GRK11.37608986
40MAP2K71.35798573
41EIF2AK11.32632998
42CDK191.31174704
43ATR1.30215956
44INSRR1.29414925
45MAP3K81.27151238
46CHEK11.25182584
47RIPK41.23487547
48LATS21.20910655
49BRD41.19985075
50STK101.17772890
51AURKB1.17412118
52ACVR1B1.16496341
53BRSK11.15670761
54CDK41.14641508
55DAPK21.13993416
56BCKDK1.11476577
57CAMK1D1.11030340
58CSNK1G11.10468843
59PNCK1.09135522
60TSSK61.04713559
61CASK1.03740763
62STK161.03185411
63TAOK31.00205424
64CDK70.98977802
65ATM0.98217894
66ALK0.97407815
67PBK0.90898659
68AURKA0.89932862
69SGK20.89895029
70PLK20.89843488
71RPS6KA50.89713568
72ADRBK10.89399887
73MAP3K60.88937992
74STK390.88555854
75MET0.86291869
76PRKCE0.82488143
77WNK40.82233075
78SRPK10.80736732
79CDK20.79453043
80PAK30.79190699
81BMPR20.75956693
82CAMK1G0.75906771
83CDK80.72503653
84CDK10.71122851
85NUAK10.70959747
86CAMKK10.68323161
87PRKCG0.67261836
88PHKG10.66663059
89PHKG20.66663059
90DMPK0.65883316
91TNIK0.65586734
92IKBKB0.64812061
93EPHA40.63315848
94STK40.62237263
95TLK10.62046432
96ERBB30.61061288
97TXK0.60735029
98KSR10.59744695
99EIF2AK20.59553516
100MELK0.58290629
101CAMK2A0.57717488
102CHUK0.57648081
103DYRK1A0.57050119
104MAPKAPK30.55633750
105MAPK100.55540750
106TRPM70.55497654
107OBSCN0.55471820
108STK380.54994318
109CSNK1G30.54623650
110CSNK1G20.54394187
111NEK60.53553604
112GRK70.52309186
113CAMKK20.52309108
114MUSK0.51432218
115PIM10.50928533
116NLK0.50478592
117ERBB40.49710436
118GRK50.48978885
119CAMK10.48803051
120EIF2AK30.48595365
121PIK3CG0.48512125
122PKN10.48376331
123MAPK70.47191496
124MINK10.45564070
125VRK10.45502183
126CDK90.45345670
127PRKACB0.45067103
128CSNK1A1L0.45051560
129CSF1R0.43976306
130PRKDC0.43940846
131BLK0.43667945
132PIK3CA0.43376870
133MAPK140.41298984
134GSK3B0.41084942
135YES10.40393554
136MAPKAPK50.40205118
137SIK30.40042845
138TEC0.39441088
139PINK10.38796026
140MAP3K50.36909581
141FGR0.36559326
142RAF10.35486235
143PRKCI0.35096075
144FRK0.34432698
145DAPK10.34007841
146SGK30.33694965
147FER0.33690247
148PAK40.33099548
149CSNK1D0.33042651
150JAK30.33018416
151PRKACA0.32129888
152CSNK1E0.32114370
153NTRK30.31837588
154CDK60.31564034
155SGK10.31321476

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.00562495
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23438687
3Cell cycle_Homo sapiens_hsa041102.84449313
4Propanoate metabolism_Homo sapiens_hsa006402.66478953
5Basal transcription factors_Homo sapiens_hsa030222.60761093
6RNA transport_Homo sapiens_hsa030132.54782602
7Butanoate metabolism_Homo sapiens_hsa006502.50521217
8Homologous recombination_Homo sapiens_hsa034402.47654727
9Protein export_Homo sapiens_hsa030602.41502321
10Vitamin B6 metabolism_Homo sapiens_hsa007502.37259493
11Fanconi anemia pathway_Homo sapiens_hsa034602.27800530
12Nitrogen metabolism_Homo sapiens_hsa009102.19525747
13Proteasome_Homo sapiens_hsa030502.17442222
14Mismatch repair_Homo sapiens_hsa034302.09142770
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07464082
16Nicotine addiction_Homo sapiens_hsa050331.96696875
17Spliceosome_Homo sapiens_hsa030401.95522148
18DNA replication_Homo sapiens_hsa030301.93767960
19Base excision repair_Homo sapiens_hsa034101.93110453
20Nucleotide excision repair_Homo sapiens_hsa034201.87220585
21mRNA surveillance pathway_Homo sapiens_hsa030151.78318778
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72641248
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.72048659
24Ether lipid metabolism_Homo sapiens_hsa005651.71148967
25RNA degradation_Homo sapiens_hsa030181.70396459
26Selenocompound metabolism_Homo sapiens_hsa004501.70300995
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69268456
28Oxidative phosphorylation_Homo sapiens_hsa001901.68044958
29RNA polymerase_Homo sapiens_hsa030201.67442587
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67372119
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63825893
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63051252
33Linoleic acid metabolism_Homo sapiens_hsa005911.62633429
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61450109
35Tryptophan metabolism_Homo sapiens_hsa003801.60514633
36Non-homologous end-joining_Homo sapiens_hsa034501.51633905
37One carbon pool by folate_Homo sapiens_hsa006701.50047594
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.45232831
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41553952
40Parkinsons disease_Homo sapiens_hsa050121.40431892
41Oocyte meiosis_Homo sapiens_hsa041141.40318500
42Collecting duct acid secretion_Homo sapiens_hsa049661.40240794
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.35304454
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32611671
45p53 signaling pathway_Homo sapiens_hsa041151.31413233
46Caffeine metabolism_Homo sapiens_hsa002321.29672056
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.23805756
48Olfactory transduction_Homo sapiens_hsa047401.22645969
49Peroxisome_Homo sapiens_hsa041461.22509188
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20785840
51mTOR signaling pathway_Homo sapiens_hsa041501.17245208
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14785616
53Huntingtons disease_Homo sapiens_hsa050161.14673039
54Herpes simplex infection_Homo sapiens_hsa051681.14361863
55Morphine addiction_Homo sapiens_hsa050321.11658227
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.10974434
57beta-Alanine metabolism_Homo sapiens_hsa004101.10041755
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.09460292
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07874192
60Circadian rhythm_Homo sapiens_hsa047101.06955618
61MicroRNAs in cancer_Homo sapiens_hsa052061.06555706
62Epstein-Barr virus infection_Homo sapiens_hsa051691.05495744
63Taste transduction_Homo sapiens_hsa047421.03740437
64Systemic lupus erythematosus_Homo sapiens_hsa053221.02718569
65Dorso-ventral axis formation_Homo sapiens_hsa043201.01906448
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.00024349
67HTLV-I infection_Homo sapiens_hsa051660.99692096
68ABC transporters_Homo sapiens_hsa020100.97567676
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95331192
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92603123
71Serotonergic synapse_Homo sapiens_hsa047260.90664240
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89548896
73Circadian entrainment_Homo sapiens_hsa047130.88816000
74Pyrimidine metabolism_Homo sapiens_hsa002400.86581373
75Sphingolipid metabolism_Homo sapiens_hsa006000.85759267
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84913741
77FoxO signaling pathway_Homo sapiens_hsa040680.82602920
78Calcium signaling pathway_Homo sapiens_hsa040200.82337514
79Purine metabolism_Homo sapiens_hsa002300.81594711
80Glutamatergic synapse_Homo sapiens_hsa047240.81379049
81Inositol phosphate metabolism_Homo sapiens_hsa005620.81071556
82Synaptic vesicle cycle_Homo sapiens_hsa047210.80761505
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79813978
84Viral carcinogenesis_Homo sapiens_hsa052030.79293688
85Type I diabetes mellitus_Homo sapiens_hsa049400.79285595
86Melanoma_Homo sapiens_hsa052180.78987226
87Pancreatic cancer_Homo sapiens_hsa052120.78808576
88GABAergic synapse_Homo sapiens_hsa047270.77215954
89Insulin secretion_Homo sapiens_hsa049110.76743294
90Colorectal cancer_Homo sapiens_hsa052100.75823583
91Fatty acid elongation_Homo sapiens_hsa000620.74541034
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73954203
93Hepatitis B_Homo sapiens_hsa051610.72278211
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71110136
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68975317
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68771651
97Measles_Homo sapiens_hsa051620.68328443
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68026415
99Salivary secretion_Homo sapiens_hsa049700.67727014
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67035214
101Metabolic pathways_Homo sapiens_hsa011000.66543869
102Vitamin digestion and absorption_Homo sapiens_hsa049770.64600309
103Prostate cancer_Homo sapiens_hsa052150.63860431
104Osteoclast differentiation_Homo sapiens_hsa043800.63095703
105Alzheimers disease_Homo sapiens_hsa050100.62162814
106Influenza A_Homo sapiens_hsa051640.62153781
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62028829
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61738949
109Chronic myeloid leukemia_Homo sapiens_hsa052200.60926754
110Type II diabetes mellitus_Homo sapiens_hsa049300.60910636
111Renal cell carcinoma_Homo sapiens_hsa052110.59828235
112Chemical carcinogenesis_Homo sapiens_hsa052040.59760023
113B cell receptor signaling pathway_Homo sapiens_hsa046620.59738529
114Small cell lung cancer_Homo sapiens_hsa052220.59437672
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58767020
116Primary immunodeficiency_Homo sapiens_hsa053400.58618625
117Legionellosis_Homo sapiens_hsa051340.57803500
118Arachidonic acid metabolism_Homo sapiens_hsa005900.55276533
119TNF signaling pathway_Homo sapiens_hsa046680.54423419
120Leishmaniasis_Homo sapiens_hsa051400.54019884
121Retinol metabolism_Homo sapiens_hsa008300.53122309
122Glycerolipid metabolism_Homo sapiens_hsa005610.53088811
123HIF-1 signaling pathway_Homo sapiens_hsa040660.52662482
124Apoptosis_Homo sapiens_hsa042100.52263096
125Fatty acid metabolism_Homo sapiens_hsa012120.51495119
126Antigen processing and presentation_Homo sapiens_hsa046120.51472279
127T cell receptor signaling pathway_Homo sapiens_hsa046600.50947650
128TGF-beta signaling pathway_Homo sapiens_hsa043500.50685891
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50474832
130Non-small cell lung cancer_Homo sapiens_hsa052230.50178819
131Glioma_Homo sapiens_hsa052140.49714676
132Prolactin signaling pathway_Homo sapiens_hsa049170.49415882
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48313562
134Hematopoietic cell lineage_Homo sapiens_hsa046400.48114715
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47654289
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46851916
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46386950
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45699155
139Acute myeloid leukemia_Homo sapiens_hsa052210.45655050
140Tuberculosis_Homo sapiens_hsa051520.44848868
141Pyruvate metabolism_Homo sapiens_hsa006200.44540305
142MAPK signaling pathway_Homo sapiens_hsa040100.44386894
143Cardiac muscle contraction_Homo sapiens_hsa042600.43942991
144Lysine degradation_Homo sapiens_hsa003100.43374347
145Choline metabolism in cancer_Homo sapiens_hsa052310.42623611
146Long-term depression_Homo sapiens_hsa047300.41673634
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41525934
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41313340
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41238966
150Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41213704
151ErbB signaling pathway_Homo sapiens_hsa040120.39755386
152Dopaminergic synapse_Homo sapiens_hsa047280.39261178
153Steroid biosynthesis_Homo sapiens_hsa001000.39176929
154Sulfur relay system_Homo sapiens_hsa041220.39066517
155Alcoholism_Homo sapiens_hsa050340.38722471
156Allograft rejection_Homo sapiens_hsa053300.38333159
157Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38256926
158Wnt signaling pathway_Homo sapiens_hsa043100.37181929
159Arginine and proline metabolism_Homo sapiens_hsa003300.36126468
160Jak-STAT signaling pathway_Homo sapiens_hsa046300.35334396
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35194731
162Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34950562
163Regulation of autophagy_Homo sapiens_hsa041400.34695639
164Thyroid cancer_Homo sapiens_hsa052160.34312325
165Adherens junction_Homo sapiens_hsa045200.33321598
166Pathways in cancer_Homo sapiens_hsa052000.31438848
167AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31316691
168Ovarian steroidogenesis_Homo sapiens_hsa049130.31034233
169Long-term potentiation_Homo sapiens_hsa047200.29849920
170Endometrial cancer_Homo sapiens_hsa052130.29493745
171Hippo signaling pathway_Homo sapiens_hsa043900.29326775
172Chemokine signaling pathway_Homo sapiens_hsa040620.29039791

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