SLC48A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.20501901
2ensheathment of neurons (GO:0007272)6.07390681
3axon ensheathment (GO:0008366)6.07390681
4myelination (GO:0042552)5.97905362
5myelin maintenance (GO:0043217)5.73417593
6long-chain fatty acid biosynthetic process (GO:0042759)5.10745045
7response to methylmercury (GO:0051597)5.00067771
8creatine metabolic process (GO:0006600)4.77258952
9synaptic vesicle maturation (GO:0016188)4.62427798
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.32076996
11amyloid precursor protein metabolic process (GO:0042982)4.24082934
12long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.23768269
13establishment of mitochondrion localization (GO:0051654)4.23208899
14cholesterol biosynthetic process (GO:0006695)4.07391401
15negative regulation of protein localization to cell surface (GO:2000009)3.99349256
16oligodendrocyte differentiation (GO:0048709)3.99043092
17positive regulation of oligodendrocyte differentiation (GO:0048714)3.90800945
18long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.90383990
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89889306
20negative regulation of neurotransmitter transport (GO:0051589)3.83319434
21regulation of collateral sprouting (GO:0048670)3.80317294
22regulation of lipoprotein metabolic process (GO:0050746)3.76418280
23negative regulation of neurotransmitter secretion (GO:0046929)3.73577925
24fatty-acyl-CoA biosynthetic process (GO:0046949)3.72973451
25proline transport (GO:0015824)3.71130652
26glutamate secretion (GO:0014047)3.69718202
27import into cell (GO:0098657)3.69060294
28response to lipoprotein particle (GO:0055094)3.67102830
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.66421856
30L-amino acid import (GO:0043092)3.62681707
31sterol biosynthetic process (GO:0016126)3.59479673
32neuronal action potential propagation (GO:0019227)3.55672360
33peptidyl-tyrosine autophosphorylation (GO:0038083)3.55394719
34fatty-acyl-CoA metabolic process (GO:0035337)3.53588461
35astrocyte development (GO:0014002)3.50208049
36membrane tubulation (GO:0097320)3.50158373
37amyloid precursor protein catabolic process (GO:0042987)3.42319295
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41876329
39water-soluble vitamin biosynthetic process (GO:0042364)3.39838275
40adhesion of symbiont to host cell (GO:0044650)3.36386530
41virion attachment to host cell (GO:0019062)3.36386530
42synaptic vesicle exocytosis (GO:0016079)3.33884899
43cellular potassium ion homeostasis (GO:0030007)3.33734953
44very long-chain fatty acid metabolic process (GO:0000038)3.33321169
45dendritic spine morphogenesis (GO:0060997)3.28374446
46photoreceptor cell differentiation (GO:0046530)3.27073940
47eye photoreceptor cell differentiation (GO:0001754)3.27073940
48detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.22489539
49detection of temperature stimulus involved in sensory perception (GO:0050961)3.22489539
50neuron remodeling (GO:0016322)3.22185242
51gamma-aminobutyric acid transport (GO:0015812)3.19795456
52glycosylceramide metabolic process (GO:0006677)3.18728600
53positive regulation of meiosis (GO:0045836)3.18337520
54substantia nigra development (GO:0021762)3.17405336
55cytochrome complex assembly (GO:0017004)3.16725357
56neurotransmitter secretion (GO:0007269)3.16504849
57isoprenoid biosynthetic process (GO:0008299)3.15340924
58apical protein localization (GO:0045176)3.15102420
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15053276
60protein palmitoylation (GO:0018345)3.14714126
61respiratory chain complex IV assembly (GO:0008535)3.14234288
62regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13183128
63thioester biosynthetic process (GO:0035384)3.12404478
64acyl-CoA biosynthetic process (GO:0071616)3.12404478
65inositol phosphate catabolic process (GO:0071545)3.11935992
66regulation of oxidative phosphorylation (GO:0002082)3.09596820
67potassium ion homeostasis (GO:0055075)3.04519612
68ATP hydrolysis coupled proton transport (GO:0015991)3.04469292
69energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.04469292
70glycerophospholipid catabolic process (GO:0046475)3.03818055
71detection of calcium ion (GO:0005513)3.03460275
72startle response (GO:0001964)3.01668950
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.01127727
74leukocyte migration involved in inflammatory response (GO:0002523)3.00951424
75asymmetric protein localization (GO:0008105)2.99455656
76response to pheromone (GO:0019236)2.99181223
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98928400
78magnesium ion transport (GO:0015693)2.98901792
79auditory receptor cell stereocilium organization (GO:0060088)2.98375726
80negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.97335218
81protein complex biogenesis (GO:0070271)2.97108970
82alanine transport (GO:0032328)2.96857179
83fucose catabolic process (GO:0019317)2.95745491
84L-fucose metabolic process (GO:0042354)2.95745491
85L-fucose catabolic process (GO:0042355)2.95745491
86C4-dicarboxylate transport (GO:0015740)2.95631915
87regulation of neurotransmitter uptake (GO:0051580)2.95614666
88axon development (GO:0061564)2.94193512
89righting reflex (GO:0060013)2.92832468
90positive regulation of meiotic cell cycle (GO:0051446)2.92272979
91protein localization to endosome (GO:0036010)2.88738424
92positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.87239889
93neuromuscular process controlling posture (GO:0050884)2.86376698
94potassium ion import (GO:0010107)2.85281344
95response to lead ion (GO:0010288)2.83890017
96response to dietary excess (GO:0002021)2.82202327
97regulation of synapse structural plasticity (GO:0051823)2.81713492
98neurotransmitter transport (GO:0006836)2.80996418
99GPI anchor biosynthetic process (GO:0006506)2.79499428
100synaptic transmission, glutamatergic (GO:0035249)2.77373510
101presynaptic membrane assembly (GO:0097105)2.77220280
102peptidyl-cysteine modification (GO:0018198)2.77090424
103regulation of neurotransmitter levels (GO:0001505)2.76340797
104adult walking behavior (GO:0007628)2.76335073
105negative regulation of response to reactive oxygen species (GO:1901032)2.75919491
106membrane raft organization (GO:0031579)2.75499322
107regulation of dendritic spine development (GO:0060998)2.75433839
108response to redox state (GO:0051775)2.74946376
109amino acid import (GO:0043090)2.74832482
110detection of temperature stimulus (GO:0016048)2.73664973
111regulation of calcium ion-dependent exocytosis (GO:0017158)2.73520647
112neuron-neuron synaptic transmission (GO:0007270)2.72561534
113regulation of synaptic vesicle transport (GO:1902803)2.72027653
114presynaptic membrane organization (GO:0097090)2.71975281
115regulation of synaptic vesicle exocytosis (GO:2000300)2.71523878
116cellular ketone body metabolic process (GO:0046950)2.67989807
117glutamate receptor signaling pathway (GO:0007215)2.67222336
118GPI anchor metabolic process (GO:0006505)2.66099405
119potassium ion transmembrane transport (GO:0071805)2.64394073
120cellular potassium ion transport (GO:0071804)2.64394073
121potassium ion transport (GO:0006813)2.64319341
122membrane depolarization during action potential (GO:0086010)2.64164179
123adhesion of symbiont to host (GO:0044406)2.63956880
124calcium ion-dependent exocytosis (GO:0017156)2.63670539
125neurotransmitter uptake (GO:0001504)2.63472050
126ionotropic glutamate receptor signaling pathway (GO:0035235)2.61922726
127negative regulation of axonogenesis (GO:0050771)2.60917947
128serotonin metabolic process (GO:0042428)2.60490026
129nerve growth factor signaling pathway (GO:0038180)2.59665658
130regulation of neurotransmitter transport (GO:0051588)2.59513495
131glycosphingolipid biosynthetic process (GO:0006688)2.59506733
132postsynaptic membrane organization (GO:0001941)2.57823642
133regulation of autophagic vacuole assembly (GO:2000785)2.57066793
134tissue regeneration (GO:0042246)2.56021460
135positive regulation of glial cell differentiation (GO:0045687)2.55969860
136mitochondrial respiratory chain complex assembly (GO:0033108)2.55450565
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54735784
138auditory behavior (GO:0031223)2.54106847
139protein polyglutamylation (GO:0018095)2.53595181
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.53289044
141negative regulation of cation channel activity (GO:2001258)2.53067596
142transmission of nerve impulse (GO:0019226)2.53014699
143glycine transport (GO:0015816)2.52604545
144endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.52095672
145regulation of neuronal synaptic plasticity (GO:0048168)2.52019753
146inositol phosphate dephosphorylation (GO:0046855)2.51066366
147phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51066366
148insulin secretion (GO:0030073)2.50898554
149myelination in peripheral nervous system (GO:0022011)2.50775909
150peripheral nervous system axon ensheathment (GO:0032292)2.50775909
151primary amino compound metabolic process (GO:1901160)2.50536251
152positive regulation of gliogenesis (GO:0014015)2.49981333
153negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.49443266
154acidic amino acid transport (GO:0015800)2.49351589
155platelet dense granule organization (GO:0060155)2.48735965
156negative regulation of acute inflammatory response (GO:0002674)2.48566624
157positive regulation of cellular amine metabolic process (GO:0033240)2.48298062
158xenobiotic catabolic process (GO:0042178)2.47867751
159retinal cone cell development (GO:0046549)2.46666214
160ketone body metabolic process (GO:1902224)2.46598334
161negative regulation of dendrite development (GO:2000171)2.45365249
162regulation of sodium ion transmembrane transporter activity (GO:2000649)2.45316393
163membrane repolarization (GO:0086009)2.45144607
164regulation of vacuole organization (GO:0044088)2.45053077
165enteric nervous system development (GO:0048484)2.44874335
166positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.44575096
167regulation of amyloid precursor protein catabolic process (GO:1902991)2.44030705
168glutathione biosynthetic process (GO:0006750)2.43967670
169positive regulation of sodium ion transmembrane transport (GO:1902307)2.43961206
170regulation of excitatory postsynaptic membrane potential (GO:0060079)2.43921310
171chemosensory behavior (GO:0007635)2.43619280
172regulation of neurotransmitter secretion (GO:0046928)2.43311419
173positive regulation of potassium ion transmembrane transport (GO:1901381)2.43271177
174regulation of hydrogen peroxide-induced cell death (GO:1903205)2.42216074
175detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41918940
176glial cell development (GO:0021782)2.41150399
177preassembly of GPI anchor in ER membrane (GO:0016254)2.40835864
178regulation of postsynaptic membrane potential (GO:0060078)2.40482181
179DNA deamination (GO:0045006)2.40096839
180Golgi to endosome transport (GO:0006895)2.39078400
181neuromuscular synaptic transmission (GO:0007274)2.38513598
182triglyceride biosynthetic process (GO:0019432)2.36395491
183cortical actin cytoskeleton organization (GO:0030866)2.33969303
184extracellular matrix assembly (GO:0085029)2.33079150
185negative regulation of execution phase of apoptosis (GO:1900118)2.32123084
186cofactor catabolic process (GO:0051187)2.32085479
187cellular response to epinephrine stimulus (GO:0071872)2.31559070
188cholesterol metabolic process (GO:0008203)2.31348739
189L-phenylalanine catabolic process (GO:0006559)2.29349158
190erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.29349158
191axon ensheathment in central nervous system (GO:0032291)10.6300399
192central nervous system myelination (GO:0022010)10.6300399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.08916810
2ZNF274_21170338_ChIP-Seq_K562_Hela2.65111212
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53973135
4REST_21632747_ChIP-Seq_MESCs_Mouse2.35078701
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33217838
6VDR_22108803_ChIP-Seq_LS180_Human2.29020807
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27013048
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.25754752
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.24729452
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22162586
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12466187
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08509646
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07876913
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99278214
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93991300
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89280317
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87713795
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84869263
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75776503
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75776503
21P300_19829295_ChIP-Seq_ESCs_Human1.71943091
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.71653337
23GBX2_23144817_ChIP-Seq_PC3_Human1.70961914
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68517793
25HTT_18923047_ChIP-ChIP_STHdh_Human1.68084470
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67006796
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66308612
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65502413
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65369878
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59957395
31SMAD4_21799915_ChIP-Seq_A2780_Human1.59266288
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57312918
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56876948
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.56628219
35GATA1_19941826_ChIP-Seq_K562_Human1.54989702
36NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.54952908
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54932773
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54796998
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50798419
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48713406
41AR_21572438_ChIP-Seq_LNCaP_Human1.47792081
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.47569572
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47287565
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45999784
45BCAT_22108803_ChIP-Seq_LS180_Human1.45368590
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42193713
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42099297
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.41750280
49AR_25329375_ChIP-Seq_VCAP_Human1.41580760
50EOMES_21245162_ChIP-Seq_HESCs_Human1.39313841
51* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38737514
52* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38737514
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36032035
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.35359498
55* TCF4_23295773_ChIP-Seq_U87_Human1.34747720
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.33364786
57TP53_22573176_ChIP-Seq_HFKS_Human1.31323738
58STAT3_23295773_ChIP-Seq_U87_Human1.31024453
59EWS_26573619_Chip-Seq_HEK293_Human1.29524669
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29378458
61FUS_26573619_Chip-Seq_HEK293_Human1.29167454
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.28057215
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.25850109
64DROSHA_22980978_ChIP-Seq_HELA_Human1.25434962
65IGF1R_20145208_ChIP-Seq_DFB_Human1.25410262
66* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24886306
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.24578330
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.23437575
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21202535
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19629113
71CBP_20019798_ChIP-Seq_JUKART_Human1.19629113
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.19227051
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17824965
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17708458
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17624279
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.16205122
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15905078
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14386444
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.13184513
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.12103803
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11107739
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10392951
83TCF4_22108803_ChIP-Seq_LS180_Human1.09852789
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09783627
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09097863
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.08881189
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08757822
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08370397
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08092533
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.08092533
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08004621
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.07832271
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06655142
94P53_22387025_ChIP-Seq_ESCs_Mouse1.06549242
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06326840
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06097451
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05719747
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.05417690
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.05398732
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03987451
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.03529716
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03087221
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03030555
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02981299
105RNF2_27304074_Chip-Seq_NSC_Mouse1.02915972
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.02872676
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02713801
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02589303
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02253411
110SCL_19346495_ChIP-Seq_HPC-7_Human1.02078812
111* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01842213
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01503675
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.00791839
114ER_23166858_ChIP-Seq_MCF-7_Human1.00761668
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00609291
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.99656567
117NCOR_22424771_ChIP-Seq_293T_Human0.99375929
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99316523
119SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98034823
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.97807476
121* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96996485
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96599140
123TAF15_26573619_Chip-Seq_HEK293_Human0.96447979
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.95986145
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93856580
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93670227
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92985252
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92905125
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.92619564
130CTCF_20526341_ChIP-Seq_ESCs_Human0.91415967
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91240905
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90744033
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90268962
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90238886
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89980588
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89489189
137IRF8_27001747_Chip-Seq_BMDM_Mouse0.87571534
138EGR1_19032775_ChIP-ChIP_M12_Human0.87288395
139GATA2_19941826_ChIP-Seq_K562_Human0.87056949
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84686768
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82032026
142EZH2_22144423_ChIP-Seq_EOC_Human0.80826971
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80519881
144REST_18959480_ChIP-ChIP_MESCs_Mouse0.80021098
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.79842466
146ESR1_20079471_ChIP-ChIP_T-47D_Human0.79457174
147P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78896642
148VDR_24787735_ChIP-Seq_THP-1_Human0.78081619
149CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76409376
150KDM2B_26808549_Chip-Seq_K562_Human0.76114224
151NANOG_19829295_ChIP-Seq_ESCs_Human0.75455123
152SOX2_19829295_ChIP-Seq_ESCs_Human0.75455123
153* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74909806
154STAT1_20625510_ChIP-Seq_HELA_Human0.74893584
155MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74855490
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74626798
157OCT4_20526341_ChIP-Seq_ESCs_Human0.74352622
158LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74195339
159SMC3_22415368_ChIP-Seq_MEFs_Mouse0.73887193
160SOX2_20726797_ChIP-Seq_SW620_Human0.73465995
161SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73170108
162NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73162795
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72697423
164* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72454026
165BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72275604
166FOXH1_21741376_ChIP-Seq_ESCs_Human0.72265542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.55716302
2MP0003950_abnormal_plasma_membrane3.51311119
3MP0003690_abnormal_glial_cell3.50757649
4MP0003329_amyloid_beta_deposits3.33206212
5MP0005058_abnormal_lysosome_morphology2.75825124
6MP0005646_abnormal_pituitary_gland2.70052643
7MP0003880_abnormal_central_pattern2.68242173
8MP0009780_abnormal_chondrocyte_physiolo2.67531010
9MP0001968_abnormal_touch/_nociception2.62219664
10MP0004270_analgesia2.57702116
11MP0003634_abnormal_glial_cell2.48918420
12MP0000604_amyloidosis2.32492832
13MP0003787_abnormal_imprinting2.29713225
14MP0004885_abnormal_endolymph2.16716580
15MP0003656_abnormal_erythrocyte_physiolo2.11969794
16MP0002837_dystrophic_cardiac_calcinosis2.09832477
17MP0001905_abnormal_dopamine_level2.07832912
18MP0005171_absent_coat_pigmentation2.07151996
19MP0008877_abnormal_DNA_methylation2.06275407
20MP0002272_abnormal_nervous_system2.05247548
21MP0001529_abnormal_vocalization2.04120714
22MP0004043_abnormal_pH_regulation2.02046733
23MP0004142_abnormal_muscle_tone1.97549307
24MP0004742_abnormal_vestibular_system1.90958695
25MP0002064_seizures1.89120898
26MP0009840_abnormal_foam_cell1.88734621
27MP0002736_abnormal_nociception_after1.88643412
28MP0008438_abnormal_cutaneous_collagen1.86660379
29MP0001486_abnormal_startle_reflex1.83916070
30MP0010386_abnormal_urinary_bladder1.81387786
31MP0002229_neurodegeneration1.80552830
32MP0008260_abnormal_autophagy1.79829733
33MP0006082_CNS_inflammation1.74988969
34MP0000372_irregular_coat_pigmentation1.66678408
35MP0002638_abnormal_pupillary_reflex1.62931041
36MP0003632_abnormal_nervous_system1.61882551
37MP0004859_abnormal_synaptic_plasticity1.61547181
38MP0003011_delayed_dark_adaptation1.60723459
39MP0004147_increased_porphyrin_level1.60027722
40MP0003633_abnormal_nervous_system1.58625536
41MP0001984_abnormal_olfaction1.54154214
42MP0003806_abnormal_nucleotide_metabolis1.53879103
43MP0008872_abnormal_physiological_respon1.52613604
44MP0003631_nervous_system_phenotype1.50703568
45MP0005167_abnormal_blood-brain_barrier1.50104292
46MP0005253_abnormal_eye_physiology1.50090840
47MP0000747_muscle_weakness1.46671986
48MP0003172_abnormal_lysosome_physiology1.46574254
49MP0005410_abnormal_fertilization1.42851126
50MP0003879_abnormal_hair_cell1.42257777
51MP0005409_darkened_coat_color1.41936550
52MP0003136_yellow_coat_color1.41598129
53MP0003075_altered_response_to1.41298898
54MP0002557_abnormal_social/conspecific_i1.39083028
55MP0002876_abnormal_thyroid_physiology1.38795361
56MP0002734_abnormal_mechanical_nocicepti1.36810995
57MP0002909_abnormal_adrenal_gland1.36509934
58MP0003195_calcinosis1.35514418
59MP0001986_abnormal_taste_sensitivity1.33667300
60MP0006036_abnormal_mitochondrial_physio1.33616293
61MP0001970_abnormal_pain_threshold1.31629947
62MP0002735_abnormal_chemical_nociception1.31334475
63MP0001958_emphysema1.29254056
64MP0009046_muscle_twitch1.28968416
65MP0008569_lethality_at_weaning1.27468422
66MP0005423_abnormal_somatic_nervous1.26834550
67MP0006072_abnormal_retinal_apoptosis1.25767487
68MP0005451_abnormal_body_composition1.23145580
69MP0005379_endocrine/exocrine_gland_phen1.22614758
70MP0003635_abnormal_synaptic_transmissio1.21440727
71MP0002090_abnormal_vision1.19894865
72MP0002102_abnormal_ear_morphology1.19845729
73MP0005551_abnormal_eye_electrophysiolog1.19108949
74MP0010678_abnormal_skin_adnexa1.17941057
75MP0001485_abnormal_pinna_reflex1.17843993
76MP0009745_abnormal_behavioral_response1.17265242
77MP0001851_eye_inflammation1.16685371
78MP0006054_spinal_hemorrhage1.14860553
79MP0005174_abnormal_tail_pigmentation1.13143588
80MP0004381_abnormal_hair_follicle1.12809664
81MP0000778_abnormal_nervous_system1.12023996
82MP0004215_abnormal_myocardial_fiber1.10604356
83MP0003283_abnormal_digestive_organ1.10544714
84MP0002733_abnormal_thermal_nociception1.10285631
85MP0003137_abnormal_impulse_conducting1.10195521
86MP0002295_abnormal_pulmonary_circulatio1.09562156
87MP0000955_abnormal_spinal_cord1.08886848
88MP0006276_abnormal_autonomic_nervous1.08358301
89MP0005084_abnormal_gallbladder_morpholo1.04316604
90MP0004134_abnormal_chest_morphology1.04025710
91MP0008875_abnormal_xenobiotic_pharmacok1.03793984
92MP0001502_abnormal_circadian_rhythm1.02902805
93MP0000749_muscle_degeneration1.02680204
94MP0003186_abnormal_redox_activity1.01658546
95MP0005636_abnormal_mineral_homeostasis1.01038906
96MP0005535_abnormal_body_temperature1.00801790
97MP0002066_abnormal_motor_capabilities/c1.00513705
98MP0005584_abnormal_enzyme/coenzyme_acti0.99719847
99MP0000383_abnormal_hair_follicle0.98041440
100MP0002882_abnormal_neuron_morphology0.97954944
101MP0004858_abnormal_nervous_system0.97738402
102MP0001756_abnormal_urination0.94315156
103MP0005623_abnormal_meninges_morphology0.93393976
104MP0004185_abnormal_adipocyte_glucose0.90492698
105MP0004036_abnormal_muscle_relaxation0.89959190
106MP0005645_abnormal_hypothalamus_physiol0.89789063
107MP0002572_abnormal_emotion/affect_behav0.89367273
108MP0010234_abnormal_vibrissa_follicle0.89054556
109MP0001944_abnormal_pancreas_morphology0.88144227
110MP0002118_abnormal_lipid_homeostasis0.86373235
111MP0003191_abnormal_cellular_cholesterol0.86251678
112MP0000003_abnormal_adipose_tissue0.85756905
113MP0004811_abnormal_neuron_physiology0.85671275
114MP0001440_abnormal_grooming_behavior0.84873918
115MP0001348_abnormal_lacrimal_gland0.83476145
116MP0005083_abnormal_biliary_tract0.83208097
117MP0005195_abnormal_posterior_eye0.81121079
118MP0004085_abnormal_heartbeat0.81010001
119MP0002163_abnormal_gland_morphology0.80625819
120MP0002063_abnormal_learning/memory/cond0.80443441
121MP0004019_abnormal_vitamin_homeostasis0.80179143
122MP0002067_abnormal_sensory_capabilities0.77966628
123MP0000427_abnormal_hair_cycle0.77805192
124MP0001963_abnormal_hearing_physiology0.77309165
125MP0000015_abnormal_ear_pigmentation0.75607147
126MP0005164_abnormal_response_to0.75588436
127MP0002752_abnormal_somatic_nervous0.74674386
128MP0000462_abnormal_digestive_system0.74614946
129MP0002933_joint_inflammation0.73086708
130MP0008775_abnormal_heart_ventricle0.72618324
131MP0004924_abnormal_behavior0.71915208
132MP0005386_behavior/neurological_phenoty0.71915208
133MP0005375_adipose_tissue_phenotype0.71784367
134MP0001299_abnormal_eye_distance/0.71066549
135MP0010329_abnormal_lipoprotein_level0.70868546
136MP0000631_abnormal_neuroendocrine_gland0.70842201
137MP0001661_extended_life_span0.70483787
138MP0003303_peritoneal_inflammation0.70382653
139MP0006035_abnormal_mitochondrial_morpho0.69857615
140MP0008874_decreased_physiological_sensi0.69249826
141MP0000465_gastrointestinal_hemorrhage0.67219912
142MP0002133_abnormal_respiratory_system0.66517634
143MP0005388_respiratory_system_phenotype0.66517634
144MP0005165_increased_susceptibility_to0.64437327
145MP0001501_abnormal_sleep_pattern0.64321318
146MP0000647_abnormal_sebaceous_gland0.63727705
147MP0000343_altered_response_to0.63088697
148MP0002419_abnormal_innate_immunity0.62961643
149MP0005332_abnormal_amino_acid0.62771408

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.85707227
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.36179792
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.36179792
4Cerebral inclusion bodies (HP:0100314)5.01542452
5Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.70862993
6Supranuclear gaze palsy (HP:0000605)4.44401586
7Peripheral hypomyelination (HP:0007182)4.35950134
8Onion bulb formation (HP:0003383)4.06674766
9Abnormality of the corticospinal tract (HP:0002492)4.05337127
10Parakeratosis (HP:0001036)4.03150183
11Focal motor seizures (HP:0011153)3.94781395
12Axonal loss (HP:0003447)3.91730401
13Sensory axonal neuropathy (HP:0003390)3.82901534
14Cerebral hypomyelination (HP:0006808)3.65377492
15Focal seizures (HP:0007359)3.46262162
16Febrile seizures (HP:0002373)3.40138718
17Abnormal auditory evoked potentials (HP:0006958)3.30252635
18Progressive macrocephaly (HP:0004481)3.23128308
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.13884740
20Segmental peripheral demyelination/remyelination (HP:0003481)3.10230860
21Hemiparesis (HP:0001269)3.07878354
22Intention tremor (HP:0002080)3.07467817
23Slow saccadic eye movements (HP:0000514)3.06498073
24Increased cerebral lipofuscin (HP:0011813)3.06028652
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.01099968
26Spastic gait (HP:0002064)2.99752277
27Acute necrotizing encephalopathy (HP:0006965)2.93977155
28Insidious onset (HP:0003587)2.90806392
29Termporal pattern (HP:0011008)2.90806392
30Retinal dysplasia (HP:0007973)2.89896916
31Ankle clonus (HP:0011448)2.88919956
32Hypothermia (HP:0002045)2.87708299
33Dysmetria (HP:0001310)2.87357166
34Abnormality of glycolysis (HP:0004366)2.85225917
35Increased serum pyruvate (HP:0003542)2.85225917
36Clumsiness (HP:0002312)2.81244716
37Loss of speech (HP:0002371)2.80680905
38Abnormal drinking behavior (HP:0030082)2.77267706
39Polydipsia (HP:0001959)2.77267706
40Cerebral hemorrhage (HP:0001342)2.74342936
41Stridor (HP:0010307)2.73107999
42Spastic paraparesis (HP:0002313)2.72258483
43Hepatosplenomegaly (HP:0001433)2.71000460
44Spastic tetraparesis (HP:0001285)2.69717642
45Mitochondrial inheritance (HP:0001427)2.67364667
46Generalized tonic-clonic seizures (HP:0002069)2.65958016
47Atonic seizures (HP:0010819)2.64678902
48Progressive cerebellar ataxia (HP:0002073)2.64337634
49Epileptic encephalopathy (HP:0200134)2.64004947
50Leukodystrophy (HP:0002415)2.62874919
51Acute encephalopathy (HP:0006846)2.60510701
52Abnormal mitochondria in muscle tissue (HP:0008316)2.57155197
53Mutism (HP:0002300)2.52896999
54Gaze-evoked nystagmus (HP:0000640)2.51758137
55Increased CSF lactate (HP:0002490)2.51404866
56Alacrima (HP:0000522)2.50639095
57Neuronal loss in central nervous system (HP:0002529)2.48970516
58Increased circulating renin level (HP:0000848)2.48496204
59Hepatocellular necrosis (HP:0001404)2.48134733
60Congenital stationary night blindness (HP:0007642)2.46401302
61Ketoacidosis (HP:0001993)2.46358373
62Dialeptic seizures (HP:0011146)2.45105200
63Epileptiform EEG discharges (HP:0011182)2.44731515
64Hyperventilation (HP:0002883)2.42322006
65Hepatic necrosis (HP:0002605)2.41389724
66Scanning speech (HP:0002168)2.40362277
67Myokymia (HP:0002411)2.39059409
68Large for gestational age (HP:0001520)2.38826722
69Visual hallucinations (HP:0002367)2.35385733
70Pancreatic cysts (HP:0001737)2.34416711
71Abnormality of midbrain morphology (HP:0002418)2.34283861
72Molar tooth sign on MRI (HP:0002419)2.34283861
73Anxiety (HP:0000739)2.33444848
74Delusions (HP:0000746)2.32645902
75Muscle fiber splitting (HP:0003555)2.32494384
76EEG with generalized epileptiform discharges (HP:0011198)2.31934416
77Paraparesis (HP:0002385)2.31415944
78Progressive neurologic deterioration (HP:0002344)2.30977551
79CNS hypomyelination (HP:0003429)2.28713761
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28457545
81Amyloidosis (HP:0011034)2.28004315
82Dysostosis multiplex (HP:0000943)2.26852196
83Attenuation of retinal blood vessels (HP:0007843)2.26596211
84Peripheral demyelination (HP:0011096)2.25986962
85Premature skin wrinkling (HP:0100678)2.25882650
86Hypokalemic alkalosis (HP:0001949)2.25856763
87True hermaphroditism (HP:0010459)2.25342613
88Abnormality of liposaccharide metabolism (HP:0010968)2.24307596
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.24307596
90Abnormality of glycolipid metabolism (HP:0010969)2.24307596
91Congenital ichthyosiform erythroderma (HP:0007431)2.22880130
92Vacuolated lymphocytes (HP:0001922)2.22310936
93Abolished electroretinogram (ERG) (HP:0000550)2.21957611
94Abnormality of macrophages (HP:0004311)2.21580020
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.21466855
96Abnormality of binocular vision (HP:0011514)2.20355888
97Diplopia (HP:0000651)2.20355888
98Abnormal eating behavior (HP:0100738)2.19996611
99Hypsarrhythmia (HP:0002521)2.18368478
100Pheochromocytoma (HP:0002666)2.18229283
101Megalencephaly (HP:0001355)2.17742640
102Metabolic alkalosis (HP:0200114)2.17684907
103Polyuria (HP:0000103)2.17058867
104Hyperinsulinemic hypoglycemia (HP:0000825)2.14910243
105Broad-based gait (HP:0002136)2.14445457
106Pancreatic fibrosis (HP:0100732)2.12922782
107Absence seizures (HP:0002121)2.12908407
108Foot dorsiflexor weakness (HP:0009027)2.11594936
109Nephronophthisis (HP:0000090)2.09735928
110Hamartoma of the eye (HP:0010568)2.08750229
111Muscular hypotonia of the trunk (HP:0008936)2.07423123
112Tongue fasciculations (HP:0001308)2.06735535
113Methylmalonic aciduria (HP:0012120)2.06573062
114Hypoplasia of the iris (HP:0007676)2.06456341
115Urinary incontinence (HP:0000020)2.04918746
116Infantile muscular hypotonia (HP:0008947)2.04513156
117Decreased central vision (HP:0007663)2.04162020
118Ketosis (HP:0001946)2.03470145
119Prolonged QT interval (HP:0001657)2.02984822
120Aplasia involving bones of the extremities (HP:0009825)2.01294997
121Aplasia involving bones of the upper limbs (HP:0009823)2.01294997
122Aplasia of the phalanges of the hand (HP:0009802)2.01294997
123Neuroendocrine neoplasm (HP:0100634)2.00886306
124Abnormal gallbladder physiology (HP:0012438)2.00602755
125Cholecystitis (HP:0001082)2.00602755
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99245898
127Abnormality of magnesium homeostasis (HP:0004921)1.99017960
128Polyphagia (HP:0002591)1.97258461
129Dysdiadochokinesis (HP:0002075)1.96788995
130Hypomagnesemia (HP:0002917)1.96293634
131Autoamputation (HP:0001218)1.96021837
132Intestinal atresia (HP:0011100)1.95187727
133Akinesia (HP:0002304)1.94951154
134Hyporeflexia of lower limbs (HP:0002600)1.94791003
135White forelock (HP:0002211)1.93093779
136Gowers sign (HP:0003391)1.92755765
137Lower limb muscle weakness (HP:0007340)1.92533747
138Progressive inability to walk (HP:0002505)1.91221741
139Hypoplastic pelvis (HP:0008839)1.91081190
140Status epilepticus (HP:0002133)1.90831066
141Limb dystonia (HP:0002451)1.90646266
142Patchy hypopigmentation of hair (HP:0011365)1.90644238
143Action tremor (HP:0002345)1.87712741
144Respiratory failure (HP:0002878)1.87044827
145Agitation (HP:0000713)1.86436782
146Abnormality of the foot musculature (HP:0001436)1.85887535
1473-Methylglutaconic aciduria (HP:0003535)1.85231227
148Postural tremor (HP:0002174)1.84927917
149Ventricular fibrillation (HP:0001663)1.84919270
150Rapidly progressive (HP:0003678)1.84596235
151Split foot (HP:0001839)1.84212823
152Abnormality of macular pigmentation (HP:0008002)1.84142347
153Hammertoe (HP:0001765)1.83057671
154Methylmalonic acidemia (HP:0002912)1.82801886
155Synostosis involving the elbow (HP:0003938)1.82306080
156Humeroradial synostosis (HP:0003041)1.82306080
157Diminished movement (HP:0002374)1.82011120
158Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81616349
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81616349
160Absent septum pellucidum (HP:0001331)1.81088125
161Conjunctival hamartoma (HP:0100780)1.80919684
162Premature rupture of membranes (HP:0001788)1.80881412
163Hyperthyroidism (HP:0000836)1.80828142
164Morphological abnormality of the inner ear (HP:0011390)1.79999797
165Poor speech (HP:0002465)1.79526989
166Renal Fanconi syndrome (HP:0001994)1.79065303
167Anteriorly placed anus (HP:0001545)1.78345872
168Abnormal EKG (HP:0003115)1.78258441
169Choreoathetosis (HP:0001266)1.77994299
170Inability to walk (HP:0002540)1.77812679
171Thickened helices (HP:0000391)1.77679199
172Episodic fever (HP:0001954)1.76510318
173Generalized myoclonic seizures (HP:0002123)1.75739945
174Rigidity (HP:0002063)1.74780706
175Partial duplication of thumb phalanx (HP:0009944)1.74502058
176Difficulty running (HP:0009046)1.74422673
177Type II lissencephaly (HP:0007260)1.74373759
178Progressive microcephaly (HP:0000253)1.73762629
179Distal sensory impairment (HP:0002936)1.73234810
180Clonus (HP:0002169)1.72266994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.68272618
2FRK4.94817078
3OXSR14.20986761
4EPHB14.18400742
5MAPKAPK53.18537768
6DAPK23.05270995
7NTRK32.99455309
8PLK22.88434264
9PBK2.73132423
10WNK42.60361601
11PKN12.59310324
12CDK192.49820414
13MAP4K22.31766613
14TESK22.19772268
15LIMK12.18985400
16BMPR1B2.17643662
17NTRK12.16460577
18MET2.13149155
19WNK12.00275684
20WNK31.99509759
21MAPK131.75520308
22ACVR1B1.67644282
23FGFR21.66604764
24PRKD31.65876924
25UHMK11.55157369
26CSNK1G31.50812507
27BCR1.48621229
28ROCK21.44978707
29MINK11.43694501
30FGR1.40900665
31NUAK11.39105604
32CLK11.38660324
33CAMK2B1.36433994
34CSNK1A1L1.35601198
35DAPK11.35197861
36PAK61.29241464
37CAMK2D1.21764177
38FER1.19312438
39MUSK1.18911029
40PLK31.15860440
41SGK4941.12285684
42SGK2231.12285684
43KSR21.11787390
44TRIM281.11609502
45MAPKAPK31.10750826
46PHKG21.10658234
47PHKG11.10658234
48CSNK1G21.10403807
49PRKCG1.09839526
50TNK21.06198608
51TNIK1.05476059
52MARK21.04514350
53ARAF1.02374855
54BLK1.02352814
55CSNK1G11.02216706
56PRKD10.98071388
57VRK20.96901463
58CAMK10.95119459
59CAMK2G0.95003518
60PDPK10.92258634
61LMTK20.91660875
62PRPF4B0.91634653
63NEK60.91567996
64PRKCI0.91091292
65CAMKK20.89119164
66MST40.88823259
67TRPM70.88108769
68CDK140.87941681
69GRK50.87757733
70BRSK10.85795204
71MAP3K130.84187418
72MAP3K120.84096295
73MAP2K60.83307687
74CSF1R0.81192493
75TIE10.80656896
76EPHA40.79029025
77EIF2AK10.78692189
78CDK50.78478955
79DAPK30.78316058
80INSRR0.78127205
81BMX0.78126391
82STK110.77924335
83CDK150.74724555
84DYRK20.74011245
85PRKCQ0.73856354
86STK160.73651053
87EIF2AK30.72940282
88GRK70.70671378
89ZAK0.69981092
90MOS0.69430943
91CDK11A0.68102663
92TYRO30.67779118
93PAK30.66988386
94CDK180.65895495
95FYN0.65840406
96CAMK2A0.65811251
97FES0.63384542
98ICK0.63357160
99PRKCE0.63337105
100ADRBK10.62618504
101MAP2K10.61060186
102PRKCH0.60911468
103ERBB30.60657337
104ADRBK20.59633428
105NTRK20.57542421
106MAPK150.57442646
107SIK30.57156102
108CAMK1G0.56861611
109ROCK10.56565635
110MAP2K20.56503577
111GSK3A0.53405816
112PDK10.53044848
113ABL20.52659990
114KIT0.50846013
115AKT30.50289835
116MAP3K10.49829051
117MAP3K40.49144899
118PRKCA0.48514833
119PNCK0.47460916
120ILK0.46846340
121SGK20.46776624
122PRKACA0.46447597
123PTK2B0.46369550
124HIPK20.46366646
125PAK10.45698010
126PDK20.44715651
127RIPK40.44303966
128PRKG10.42805486
129BMPR20.42480055
130RPS6KA50.42434960
131PRKCZ0.42192450
132MAP2K70.42174993
133ERN10.41718465
134STK380.39134222
135PRKACB0.39026510
136CAMKK10.37774822
137PRKAA10.37115525
138BRSK20.36933582
139PINK10.36921035
140GRK10.36484794
141MAPK120.36337118
142PRKG20.36201115
143DMPK0.35862016
144BCKDK0.35276838
145DDR20.34485462
146MARK10.34371190
147CASK0.34228546
148IRAK20.34105025
149PAK20.33525987
150CSNK1A10.33325283
151LCK0.32833737
152SRC0.32050425
153RET0.31801485
154MAP3K20.31659307

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.64105128
2Fatty acid elongation_Homo sapiens_hsa000624.36443043
3Steroid biosynthesis_Homo sapiens_hsa001004.23183165
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93224329
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.84752336
6Ether lipid metabolism_Homo sapiens_hsa005652.60029036
7Insulin secretion_Homo sapiens_hsa049112.48862423
8Nicotine addiction_Homo sapiens_hsa050332.45605148
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40232111
10Nitrogen metabolism_Homo sapiens_hsa009102.30888993
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.19566998
12Vitamin B6 metabolism_Homo sapiens_hsa007501.97878017
13Lysosome_Homo sapiens_hsa041421.82416590
14Sphingolipid metabolism_Homo sapiens_hsa006001.65020984
15Histidine metabolism_Homo sapiens_hsa003401.63807098
16Phototransduction_Homo sapiens_hsa047441.61261527
17Oxidative phosphorylation_Homo sapiens_hsa001901.60594558
18Sulfur metabolism_Homo sapiens_hsa009201.54250534
19Amphetamine addiction_Homo sapiens_hsa050311.50025302
20Protein export_Homo sapiens_hsa030601.47573627
21Tryptophan metabolism_Homo sapiens_hsa003801.45058296
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34722226
23Collecting duct acid secretion_Homo sapiens_hsa049661.32724720
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29764541
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27592955
26Linoleic acid metabolism_Homo sapiens_hsa005911.27566368
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27491096
28Butanoate metabolism_Homo sapiens_hsa006501.27441072
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23776268
30Dopaminergic synapse_Homo sapiens_hsa047281.23462627
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21970585
32Regulation of autophagy_Homo sapiens_hsa041401.17002669
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15708834
34Parkinsons disease_Homo sapiens_hsa050121.14649428
35Fatty acid metabolism_Homo sapiens_hsa012121.12193343
36Alzheimers disease_Homo sapiens_hsa050101.11209674
37Taste transduction_Homo sapiens_hsa047421.08784633
38GABAergic synapse_Homo sapiens_hsa047271.08409203
39Phagosome_Homo sapiens_hsa041451.08290341
40Sphingolipid signaling pathway_Homo sapiens_hsa040711.07737128
41Calcium signaling pathway_Homo sapiens_hsa040201.06803824
42Vibrio cholerae infection_Homo sapiens_hsa051101.05968776
43Long-term potentiation_Homo sapiens_hsa047201.00583316
44Axon guidance_Homo sapiens_hsa043600.99962231
45Rheumatoid arthritis_Homo sapiens_hsa053230.98810593
46Arginine and proline metabolism_Homo sapiens_hsa003300.98656405
47Olfactory transduction_Homo sapiens_hsa047400.98091301
48Renal cell carcinoma_Homo sapiens_hsa052110.96923723
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94133622
50Propanoate metabolism_Homo sapiens_hsa006400.90973788
51Proteasome_Homo sapiens_hsa030500.90171211
52Serotonergic synapse_Homo sapiens_hsa047260.89032643
53Malaria_Homo sapiens_hsa051440.87772947
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87417206
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87106623
56Glutamatergic synapse_Homo sapiens_hsa047240.86434801
57Endocytosis_Homo sapiens_hsa041440.85682539
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85012835
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84209881
60Huntingtons disease_Homo sapiens_hsa050160.82701561
61Selenocompound metabolism_Homo sapiens_hsa004500.82614842
62Other glycan degradation_Homo sapiens_hsa005110.82173193
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80206308
64Peroxisome_Homo sapiens_hsa041460.78410352
65Folate biosynthesis_Homo sapiens_hsa007900.78193246
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77160008
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76909818
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76299948
69Glutathione metabolism_Homo sapiens_hsa004800.76224485
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76000605
71Mineral absorption_Homo sapiens_hsa049780.75863574
72Arachidonic acid metabolism_Homo sapiens_hsa005900.75495422
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74653718
74Morphine addiction_Homo sapiens_hsa050320.74579350
75cAMP signaling pathway_Homo sapiens_hsa040240.73232629
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72726696
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.72650993
78Circadian rhythm_Homo sapiens_hsa047100.71308167
79Synaptic vesicle cycle_Homo sapiens_hsa047210.70510565
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67701319
81Long-term depression_Homo sapiens_hsa047300.67486984
82Oxytocin signaling pathway_Homo sapiens_hsa049210.65889727
83RNA polymerase_Homo sapiens_hsa030200.65745372
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65481942
85Thyroid hormone synthesis_Homo sapiens_hsa049180.64343568
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64230392
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.63956178
88Salivary secretion_Homo sapiens_hsa049700.63421258
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63164676
90Fatty acid biosynthesis_Homo sapiens_hsa000610.62621834
91Cardiac muscle contraction_Homo sapiens_hsa042600.62421234
92Gastric acid secretion_Homo sapiens_hsa049710.61907412
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61318508
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.60735316
95Cocaine addiction_Homo sapiens_hsa050300.60505008
96Basal transcription factors_Homo sapiens_hsa030220.57602673
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.55498312
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.55027087
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51802841
100Ras signaling pathway_Homo sapiens_hsa040140.50593557
101PPAR signaling pathway_Homo sapiens_hsa033200.50592153
102Pancreatic secretion_Homo sapiens_hsa049720.48856549
103Circadian entrainment_Homo sapiens_hsa047130.48795250
104Glycerolipid metabolism_Homo sapiens_hsa005610.48047412
105One carbon pool by folate_Homo sapiens_hsa006700.47483011
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47337130
107Pyruvate metabolism_Homo sapiens_hsa006200.47245218
108Oocyte meiosis_Homo sapiens_hsa041140.46616861
109Renin secretion_Homo sapiens_hsa049240.46452612
110Ovarian steroidogenesis_Homo sapiens_hsa049130.44670461
111Purine metabolism_Homo sapiens_hsa002300.43521230
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43270662
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42404135
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42124620
115Salmonella infection_Homo sapiens_hsa051320.39486080
116ABC transporters_Homo sapiens_hsa020100.37173662
117Metabolic pathways_Homo sapiens_hsa011000.37093641
118Tight junction_Homo sapiens_hsa045300.37060397
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34859003
120Gap junction_Homo sapiens_hsa045400.34848252
121ECM-receptor interaction_Homo sapiens_hsa045120.34431581
122Cholinergic synapse_Homo sapiens_hsa047250.34350283
123Chemical carcinogenesis_Homo sapiens_hsa052040.34131551
124beta-Alanine metabolism_Homo sapiens_hsa004100.34064599
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33661532
126Dorso-ventral axis formation_Homo sapiens_hsa043200.33422086
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32827361
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.32819070
129Prion diseases_Homo sapiens_hsa050200.32658760
130Vitamin digestion and absorption_Homo sapiens_hsa049770.30423609
131Pertussis_Homo sapiens_hsa051330.28784199
132Fatty acid degradation_Homo sapiens_hsa000710.28648612
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28051746
134Bile secretion_Homo sapiens_hsa049760.28046740

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