SLC46A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytoplasm. This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.86077340
2L-phenylalanine catabolic process (GO:0006559)6.86077340
3L-phenylalanine metabolic process (GO:0006558)6.54416618
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.54416618
5aromatic amino acid family catabolic process (GO:0009074)6.30288433
6angiotensin maturation (GO:0002003)6.02326582
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.98582398
8tryptophan catabolic process (GO:0006569)5.90652517
9indole-containing compound catabolic process (GO:0042436)5.90652517
10indolalkylamine catabolic process (GO:0046218)5.90652517
11kynurenine metabolic process (GO:0070189)5.70925343
12tryptophan metabolic process (GO:0006568)5.64121573
13bile acid biosynthetic process (GO:0006699)5.37297959
14alpha-linolenic acid metabolic process (GO:0036109)5.17503348
15urea cycle (GO:0000050)5.13453818
16urea metabolic process (GO:0019627)5.13453818
17glyoxylate metabolic process (GO:0046487)5.07168279
18high-density lipoprotein particle remodeling (GO:0034375)5.02897972
19sulfur amino acid catabolic process (GO:0000098)5.02615991
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98636086
21peptidyl-glutamic acid carboxylation (GO:0017187)4.94246812
22protein carboxylation (GO:0018214)4.94246812
23complement activation, alternative pathway (GO:0006957)4.92868910
24cysteine metabolic process (GO:0006534)4.86997278
25regulation of protein activation cascade (GO:2000257)4.82274444
26regulation of cholesterol esterification (GO:0010872)4.80769352
27negative regulation of fibrinolysis (GO:0051918)4.78672973
28nitrogen cycle metabolic process (GO:0071941)4.70994780
29fat-soluble vitamin biosynthetic process (GO:0042362)4.69015752
30regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.66342649
31bile acid metabolic process (GO:0008206)4.64997770
32regulation of fibrinolysis (GO:0051917)4.63405650
33regulation of complement activation (GO:0030449)4.54673364
34regulation of triglyceride catabolic process (GO:0010896)4.54384401
35aromatic amino acid family metabolic process (GO:0009072)4.52676562
36lysine metabolic process (GO:0006553)4.51248875
37lysine catabolic process (GO:0006554)4.51248875
38reverse cholesterol transport (GO:0043691)4.51213191
39protein-lipid complex remodeling (GO:0034368)4.46091314
40macromolecular complex remodeling (GO:0034367)4.46091314
41plasma lipoprotein particle remodeling (GO:0034369)4.46091314
42phospholipid efflux (GO:0033700)4.44380964
43epoxygenase P450 pathway (GO:0019373)4.39815825
44homocysteine metabolic process (GO:0050667)4.38731641
45amine catabolic process (GO:0009310)4.36024128
46cellular biogenic amine catabolic process (GO:0042402)4.36024128
47serine family amino acid catabolic process (GO:0009071)4.31170638
48negative regulation of sterol transport (GO:0032372)4.28379504
49negative regulation of cholesterol transport (GO:0032375)4.28379504
50tyrosine metabolic process (GO:0006570)4.27684487
51hormone catabolic process (GO:0042447)4.22722548
52amino-acid betaine metabolic process (GO:0006577)4.20656202
53lipoprotein transport (GO:0042953)4.18098523
54indolalkylamine metabolic process (GO:0006586)4.15835150
55bile acid and bile salt transport (GO:0015721)4.15797229
56drug catabolic process (GO:0042737)4.15471700
57alpha-amino acid catabolic process (GO:1901606)4.15037829
58NADH metabolic process (GO:0006734)4.11732181
59low-density lipoprotein particle remodeling (GO:0034374)4.07332607
60cholesterol efflux (GO:0033344)4.07307971
61ethanol oxidation (GO:0006069)4.07288385
62acylglycerol homeostasis (GO:0055090)4.06891122
63triglyceride homeostasis (GO:0070328)4.06891122
64plasma lipoprotein particle assembly (GO:0034377)4.04707862
65cellular glucuronidation (GO:0052695)4.04309859
66plasma lipoprotein particle clearance (GO:0034381)4.02812746
67dicarboxylic acid biosynthetic process (GO:0043650)3.98061070
68coenzyme catabolic process (GO:0009109)3.86697571
69glutamate metabolic process (GO:0006536)3.86027597
70benzene-containing compound metabolic process (GO:0042537)3.85387777
71exogenous drug catabolic process (GO:0042738)3.84495619
72cellular amino acid catabolic process (GO:0009063)3.83549747
73cellular modified amino acid catabolic process (GO:0042219)3.82646955
74intestinal absorption (GO:0050892)3.82520231
75very-low-density lipoprotein particle assembly (GO:0034379)3.80634662
76antigen processing and presentation of endogenous antigen (GO:0019883)3.80562887
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76349348
78omega-hydroxylase P450 pathway (GO:0097267)3.72825105
79complement activation, classical pathway (GO:0006958)3.71243718
80flavonoid metabolic process (GO:0009812)3.70787288
81protein-lipid complex assembly (GO:0065005)3.68230115
82phospholipid homeostasis (GO:0055091)3.65000503
83imidazole-containing compound metabolic process (GO:0052803)3.64288408
84plasma lipoprotein particle organization (GO:0071827)3.61933973
85complement activation (GO:0006956)3.61706672
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60896909
87glucuronate metabolic process (GO:0019585)3.59847931
88uronic acid metabolic process (GO:0006063)3.59847931
89glycine metabolic process (GO:0006544)3.58928623
90cellular ketone body metabolic process (GO:0046950)3.55843267
91positive regulation of lipoprotein lipase activity (GO:0051006)3.54796839
92positive regulation of triglyceride lipase activity (GO:0061365)3.54796839
93valine metabolic process (GO:0006573)3.52636131
94serine family amino acid metabolic process (GO:0009069)3.52449318
95protein activation cascade (GO:0072376)3.52369605
96intestinal cholesterol absorption (GO:0030299)3.52332085
97short-chain fatty acid metabolic process (GO:0046459)3.51671053
98regulation of cholesterol homeostasis (GO:2000188)3.51328260
99cholesterol homeostasis (GO:0042632)3.50427530
100positive regulation of lipid catabolic process (GO:0050996)3.47624345
101regulation of bile acid biosynthetic process (GO:0070857)3.46971076
102arginine metabolic process (GO:0006525)3.46094562
103cofactor catabolic process (GO:0051187)3.44889678
104organic acid catabolic process (GO:0016054)3.44739427
105carboxylic acid catabolic process (GO:0046395)3.44739427
106sterol homeostasis (GO:0055092)3.44235628
107protein-lipid complex subunit organization (GO:0071825)3.43512951
108negative regulation of lipase activity (GO:0060192)3.43012965
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42960371
110acetyl-CoA metabolic process (GO:0006084)3.42141620
111fibrinolysis (GO:0042730)3.42022367
112drug metabolic process (GO:0017144)3.40419107
113fructose metabolic process (GO:0006000)3.34649229
114peptide catabolic process (GO:0043171)3.33466577
115glycosphingolipid catabolic process (GO:0046479)3.21966796
116alkaloid metabolic process (GO:0009820)3.20638446
117regulation of cellular extravasation (GO:0002691)3.11207934
118detection of other organism (GO:0098543)3.08490559
119glycolipid catabolic process (GO:0019377)3.08432311
120adhesion of symbiont to host (GO:0044406)3.00105510
121detection of bacterium (GO:0016045)2.99132398
122regulation of guanylate cyclase activity (GO:0031282)2.98517088
123adhesion of symbiont to host cell (GO:0044650)2.93592707
124virion attachment to host cell (GO:0019062)2.93592707
125negative regulation of cell killing (GO:0031342)2.93294234
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93294234
127ethanol metabolic process (GO:0006067)2.91669844
128positive regulation of gamma-delta T cell activation (GO:0046645)2.90260112
129lipoprotein metabolic process (GO:0042157)2.82658903
130regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.81094191
131endocrine process (GO:0050886)2.81094191
132regulation of systemic arterial blood pressure by hormone (GO:0001990)2.81094191
133phenylpropanoid metabolic process (GO:0009698)2.74866546
134detection of external biotic stimulus (GO:0098581)2.68683390
135ceramide catabolic process (GO:0046514)2.67265232
136drug transport (GO:0015893)2.63568319
137maintenance of gastrointestinal epithelium (GO:0030277)2.61428519
138diacylglycerol metabolic process (GO:0046339)2.59750898
139leukotriene metabolic process (GO:0006691)2.58335280
140drug transmembrane transport (GO:0006855)2.54712207
141arachidonic acid metabolic process (GO:0019369)2.54336233
142renal system process involved in regulation of blood volume (GO:0001977)2.50719200
143regulation of gamma-delta T cell activation (GO:0046643)2.49370429
144peptide hormone processing (GO:0016486)2.47957204
145regulation of gamma-delta T cell differentiation (GO:0045586)2.46761674
146regulation of vitamin metabolic process (GO:0030656)2.42630180
147detection of molecule of bacterial origin (GO:0032490)2.41998363
148immunoglobulin mediated immune response (GO:0016064)2.41176220
149regulation of systemic arterial blood pressure (GO:0003073)2.36811277
150regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34261250
151vitamin D metabolic process (GO:0042359)2.33891198
152heme transport (GO:0015886)2.33340487
153positive regulation of cellular amide metabolic process (GO:0034250)2.32463122
154acute-phase response (GO:0006953)2.31900911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.38788651
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.52116196
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.11357643
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.89780865
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.66474132
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.37821275
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.37335244
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.63749800
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61580099
10GATA1_22025678_ChIP-Seq_K562_Human2.78026290
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.70222163
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02679299
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4431853
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95257513
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94497503
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91401947
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67507947
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63345998
19CLOCK_20551151_ChIP-Seq_293T_Human1.63213634
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61278710
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.59187004
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53921035
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.53508348
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.52518356
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51258976
26SOX2_20726797_ChIP-Seq_SW620_Human1.44573224
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.43338622
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42936778
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.40081480
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35669649
31SPI1_23127762_ChIP-Seq_K562_Human1.33446099
32VDR_24763502_ChIP-Seq_THP-1_Human1.31430463
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30631777
34* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29824196
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29667284
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29311131
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.28047238
38HNF4A_19822575_ChIP-Seq_HepG2_Human1.26492957
39GATA1_19941826_ChIP-Seq_K562_Human1.24243812
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21604167
41MYB_26560356_Chip-Seq_TH2_Human1.21287447
42SCL_19346495_ChIP-Seq_HPC-7_Human1.20629805
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19653709
44SPI1_23547873_ChIP-Seq_NB4_Human1.17189298
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.16761388
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13975852
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13406295
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.13114520
49* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10881677
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10125142
51MYB_26560356_Chip-Seq_TH1_Human1.06763609
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04775658
53HTT_18923047_ChIP-ChIP_STHdh_Human1.03949740
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00006206
55ESR1_20079471_ChIP-ChIP_T-47D_Human0.99258812
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97015687
57* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96311624
58RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96159736
59* GATA4_25053715_ChIP-Seq_YYC3_Human0.96059565
60BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94623947
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94562825
62GATA3_27048872_Chip-Seq_THYMUS_Human0.93956648
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93842759
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93670935
65GATA2_19941826_ChIP-Seq_K562_Human0.93596040
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91221929
67EGR1_19032775_ChIP-ChIP_M12_Human0.85865446
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85814134
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85486146
70GATA3_26560356_Chip-Seq_TH2_Human0.85142167
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85055528
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82644802
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82432210
74P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82050744
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81337233
76ESR1_21235772_ChIP-Seq_MCF-7_Human0.80837566
77ESR2_21235772_ChIP-Seq_MCF-7_Human0.80296775
78VDR_21846776_ChIP-Seq_THP-1_Human0.80085718
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79984679
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79887296
81UTX_26944678_Chip-Seq_JUKART_Human0.79779018
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79690907
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.77089680
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75708503
85RUNX_20019798_ChIP-Seq_JUKART_Human0.73314908
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73094424
87RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72547515
88ZNF263_19887448_ChIP-Seq_K562_Human0.71640380
89* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.71312377
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70863440
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70838338
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70237584
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70110664
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.69456213
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66845664
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.65625888
97MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65174311
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62641617
99LXR_22292898_ChIP-Seq_THP-1_Human0.62407263
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62272818
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62084099
102VDR_24787735_ChIP-Seq_THP-1_Human0.60632944
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.60540253
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.59786808
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.59523220
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.59523220
107CEBPB_22108803_ChIP-Seq_LS180_Human0.59493357
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.58909398
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58553556
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.58164015
111AR_20517297_ChIP-Seq_VCAP_Human0.57280060
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54497284
113PU_27001747_Chip-Seq_BMDM_Mouse0.54489277
114RARA_24833708_ChIP-Seq_LIVER_Mouse0.54419654
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.52740109
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52594908
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.52286647
118* GATA6_25053715_ChIP-Seq_YYC3_Human0.51835379
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.51579526
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51326879
121PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51004623
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50843762
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.50795618
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.50436851
125* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.50429202
126MAF_26560356_Chip-Seq_TH1_Human0.50131951
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49769526
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.48961252
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48728610
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.48393185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.48141414
2MP0005360_urolithiasis6.82037561
3MP0005085_abnormal_gallbladder_physiolo5.72350583
4MP0005365_abnormal_bile_salt5.41291912
5MP0008875_abnormal_xenobiotic_pharmacok4.99276685
6MP0003252_abnormal_bile_duct3.79470388
7MP0003806_abnormal_nucleotide_metabolis3.62942341
8MP0009840_abnormal_foam_cell3.58994011
9MP0010329_abnormal_lipoprotein_level3.30276410
10MP0002138_abnormal_hepatobiliary_system2.71660032
11MP0005083_abnormal_biliary_tract2.61561731
12MP0001666_abnormal_nutrient_absorption2.59171936
13MP0003191_abnormal_cellular_cholesterol2.53261826
14MP0005332_abnormal_amino_acid2.47089030
15MP0010155_abnormal_intestine_physiology2.29527127
16MP0000609_abnormal_liver_physiology2.20371104
17MP0004019_abnormal_vitamin_homeostasis2.09624410
18MP0003195_calcinosis2.08979813
19MP0002118_abnormal_lipid_homeostasis1.98878585
20MP0005319_abnormal_enzyme/_coenzyme1.87213068
21MP0010234_abnormal_vibrissa_follicle1.74648199
22MP0003656_abnormal_erythrocyte_physiolo1.69428147
23MP0002254_reproductive_system_inflammat1.69052397
24MP0001764_abnormal_homeostasis1.64934081
25MP0003868_abnormal_feces_composition1.63354229
26MP0003866_abnormal_defecation1.60780183
27MP0004264_abnormal_extraembryonic_tissu1.59111942
28MP0005584_abnormal_enzyme/coenzyme_acti1.53273607
29MP0005000_abnormal_immune_tolerance1.40441245
30MP0009643_abnormal_urine_homeostasis1.40136889
31MP0005058_abnormal_lysosome_morphology1.38465006
32MP0000465_gastrointestinal_hemorrhage1.38097056
33MP0002148_abnormal_hypersensitivity_rea1.36236362
34MP0009764_decreased_sensitivity_to1.32374068
35MP0001533_abnormal_skeleton_physiology1.25868906
36MP0003011_delayed_dark_adaptation1.24937971
37MP0000598_abnormal_liver_morphology1.21156824
38MP0009697_abnormal_copulation1.19943285
39MP0001835_abnormal_antigen_presentation1.19704662
40MP0008469_abnormal_protein_level1.19356421
41MP0003763_abnormal_thymus_physiology1.16238590
42MP0005409_darkened_coat_color1.15338685
43MP0003186_abnormal_redox_activity1.12572184
44MP0008004_abnormal_stomach_pH1.11792560
45MP0001819_abnormal_immune_cell1.10581911
46MP0002420_abnormal_adaptive_immunity1.10578208
47MP0000604_amyloidosis1.09927329
48MP0008260_abnormal_autophagy1.07263181
49MP0009763_increased_sensitivity_to1.06143834
50MP0001873_stomach_inflammation1.05766443
51MP0010368_abnormal_lymphatic_system1.05515803
52MP0009333_abnormal_splenocyte_physiolog1.05208627
53MP0005647_abnormal_sex_gland1.05114575
54MP0005451_abnormal_body_composition1.03708958
55MP0002396_abnormal_hematopoietic_system1.02874605
56MP0005464_abnormal_platelet_physiology1.02729084
57MP0003705_abnormal_hypodermis_morpholog1.02081369
58MP0000490_abnormal_crypts_of0.99954573
59MP0005636_abnormal_mineral_homeostasis0.98088258
60MP0003436_decreased_susceptibility_to0.97805776
61MP0001765_abnormal_ion_homeostasis0.97762320
62MP0001853_heart_inflammation0.97376890
63MP0005670_abnormal_white_adipose0.95076786
64MP0002998_abnormal_bone_remodeling0.94175352
65MP0006082_CNS_inflammation0.93828064
66MP0003690_abnormal_glial_cell0.90696936
67MP0005408_hypopigmentation0.89737841
68MP0009642_abnormal_blood_homeostasis0.89503778
69MP0001664_abnormal_digestion0.88313006
70MP0001663_abnormal_digestive_system0.86008713
71MP0009765_abnormal_xenobiotic_induced0.85587929
72MP0003828_pulmonary_edema0.85072679
73MP0001881_abnormal_mammary_gland0.84514772
74MP0004130_abnormal_muscle_cell0.84277228
75MP0000716_abnormal_immune_system0.80869799
76MP0005084_abnormal_gallbladder_morpholo0.79417828
77MP0002078_abnormal_glucose_homeostasis0.79377698
78MP0005220_abnormal_exocrine_pancreas0.79191782
79MP0005334_abnormal_fat_pad0.77930439
80MP0003300_gastrointestinal_ulcer0.76632794
81MP0000858_altered_metastatic_potential0.75993518
82MP0005376_homeostasis/metabolism_phenot0.75700953
83MP0003724_increased_susceptibility_to0.74693239
84MP0002928_abnormal_bile_duct0.74663354
85MP0000477_abnormal_intestine_morphology0.74477758
86MP0006036_abnormal_mitochondrial_physio0.73717683
87MP0002419_abnormal_innate_immunity0.73299868
88MP0002876_abnormal_thyroid_physiology0.72876435
89MP0005535_abnormal_body_temperature0.72106218
90MP0001851_eye_inflammation0.71970628
91MP0002405_respiratory_system_inflammati0.71106171
92MP0004883_abnormal_blood_vessel0.70107674
93MP0002971_abnormal_brown_adipose0.70102970
94MP0003879_abnormal_hair_cell0.68593925
95MP0001756_abnormal_urination0.66526845
96MP0002136_abnormal_kidney_physiology0.66469095
97MP0005165_increased_susceptibility_to0.66288371
98MP0001845_abnormal_inflammatory_respons0.65541631
99MP0005387_immune_system_phenotype0.65240507
100MP0001790_abnormal_immune_system0.65240507
101MP0003172_abnormal_lysosome_physiology0.64476451
102MP0000685_abnormal_immune_system0.63424365
103MP0003075_altered_response_to0.62629814
104MP0004147_increased_porphyrin_level0.62263834
105MP0005167_abnormal_blood-brain_barrier0.61566677
106MP0002166_altered_tumor_susceptibility0.60916974
107MP0005266_abnormal_metabolism0.59478270
108MP0005025_abnormal_response_to0.58951236
109MP0001800_abnormal_humoral_immune0.58911961
110MP0003638_abnormal_response/metabolism_0.57701088
111MP0004782_abnormal_surfactant_physiolog0.54785986
112MP0005448_abnormal_energy_balance0.54220119
113MP0004947_skin_inflammation0.53608170
114MP0008872_abnormal_physiological_respon0.53561912
115MP0000249_abnormal_blood_vessel0.53407595
116MP0008873_increased_physiological_sensi0.52001468
117MP0005671_abnormal_response_to0.50662230
118MP0005166_decreased_susceptibility_to0.50315504
119MP0002837_dystrophic_cardiac_calcinosis0.48738588
120MP0002132_abnormal_respiratory_system0.47703124
121MP0008874_decreased_physiological_sensi0.47273570
122MP0003303_peritoneal_inflammation0.47256238
123MP0009115_abnormal_fat_cell0.46290306
124MP0009384_cardiac_valve_regurgitation0.45671578
125MP0009785_altered_susceptibility_to0.45312671
126MP0002723_abnormal_immune_serum0.44491878
127MP0005666_abnormal_adipose_tissue0.43896663
128MP0002452_abnormal_antigen_presenting0.42747932
129MP0000639_abnormal_adrenal_gland0.42747836
130MP0004510_myositis0.41662700
131MP0001661_extended_life_span0.40373115
132MP0003183_abnormal_peptide_metabolism0.40194843

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.49846475
2Deep venous thrombosis (HP:0002625)6.32368214
3Intrahepatic cholestasis (HP:0001406)6.29002417
4Xanthomatosis (HP:0000991)5.89474087
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.76927606
6Prolonged partial thromboplastin time (HP:0003645)5.67172091
7Complement deficiency (HP:0004431)5.51030318
8Hypobetalipoproteinemia (HP:0003563)5.39130086
9Hyperlipoproteinemia (HP:0010980)4.92014688
10Joint hemorrhage (HP:0005261)4.55513187
11Hypolipoproteinemia (HP:0010981)4.17262690
12Abnormality of the common coagulation pathway (HP:0010990)4.16686698
13Epidermoid cyst (HP:0200040)4.14664059
14Abnormality of complement system (HP:0005339)4.08434357
15Eczematoid dermatitis (HP:0000976)3.97843706
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.95649037
17Hyperammonemia (HP:0001987)3.95422645
18Ketosis (HP:0001946)3.94931189
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92232313
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.82399801
21Chronic diarrhea (HP:0002028)3.79209128
22Hypoglycemic coma (HP:0001325)3.77164364
23Hypoalphalipoproteinemia (HP:0003233)3.76002129
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.73238357
25Abnormality of methionine metabolism (HP:0010901)3.72881729
26Fat malabsorption (HP:0002630)3.70936540
27Systemic lupus erythematosus (HP:0002725)3.69743058
28Hyperglycinemia (HP:0002154)3.64484931
29Hyperglycinuria (HP:0003108)3.61297617
30Abnormality of the intrinsic pathway (HP:0010989)3.57847683
31Hypercholesterolemia (HP:0003124)3.53806798
32Conjugated hyperbilirubinemia (HP:0002908)3.45617112
33Abnormality of glycine metabolism (HP:0010895)3.44534221
34Abnormality of serine family amino acid metabolism (HP:0010894)3.44534221
35Myocardial infarction (HP:0001658)3.40805194
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29988921
37Hyperbilirubinemia (HP:0002904)3.29206047
38Abnormality of fatty-acid metabolism (HP:0004359)3.29019334
39Abnormality of pyrimidine metabolism (HP:0004353)3.13203877
40Delayed CNS myelination (HP:0002188)3.06884731
41Ketoacidosis (HP:0001993)3.01525980
42Hepatocellular carcinoma (HP:0001402)2.97914666
43Glomerulonephritis (HP:0000099)2.94023320
44Abnormality of nucleobase metabolism (HP:0010932)2.87796905
45Abnormality of macrophages (HP:0004311)2.78853894
46Recurrent abscess formation (HP:0002722)2.76978886
47Acanthocytosis (HP:0001927)2.75321370
48Abnormality of purine metabolism (HP:0004352)2.75093419
49Steatorrhea (HP:0002570)2.75014462
50Recurrent gram-negative bacterial infections (HP:0005420)2.74232311
51Orchitis (HP:0100796)2.73237507
52Myositis (HP:0100614)2.70533102
53Metabolic acidosis (HP:0001942)2.62274055
54Widely patent fontanelles and sutures (HP:0004492)2.60559581
55Hypoglycemic seizures (HP:0002173)2.59722066
56Poikilocytosis (HP:0004447)2.58413765
57Gout (HP:0001997)2.53816962
58Gingival bleeding (HP:0000225)2.52492096
59Spontaneous hematomas (HP:0007420)2.50529384
60Skin nodule (HP:0200036)2.50403015
61Generalized aminoaciduria (HP:0002909)2.49578218
62Vascular calcification (HP:0004934)2.48141881
63Gingivitis (HP:0000230)2.46780204
64Hypochromic microcytic anemia (HP:0004840)2.46737115
65Recurrent bacterial skin infections (HP:0005406)2.45376064
66Abnormality of serum amino acid levels (HP:0003112)2.45237987
67Mitral stenosis (HP:0001718)2.44383204
68Late onset (HP:0003584)2.42697286
69Spontaneous abortion (HP:0005268)2.42432521
70Hypophosphatemia (HP:0002148)2.41587756
71Thin bony cortex (HP:0002753)2.39543660
72Renal cortical cysts (HP:0000803)2.39482405
73Esophageal varix (HP:0002040)2.37239443
74Abnormal gallbladder morphology (HP:0012437)2.36167531
75Nausea (HP:0002018)2.35332931
76Decreased circulating renin level (HP:0003351)2.33824478
77Dicarboxylic aciduria (HP:0003215)2.30050668
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30050668
79Sensorimotor neuropathy (HP:0007141)2.29893929
80Brushfield spots (HP:0001088)2.29317769
81Retrobulbar optic neuritis (HP:0100654)2.28299060
82Optic neuritis (HP:0100653)2.28299060
83Cholelithiasis (HP:0001081)2.26791207
84Abnormality of vitamin metabolism (HP:0100508)2.26397547
85Abnormality of transition element cation homeostasis (HP:0011030)2.25788360
86Abnormality of the vitamin B12 metabolism (HP:0004341)2.25215073
87Vacuolated lymphocytes (HP:0001922)2.23698583
88Abnormality of glycolipid metabolism (HP:0010969)2.23215246
89Abnormality of liposaccharide metabolism (HP:0010968)2.23215246
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.23215246
91Abnormality of iron homeostasis (HP:0011031)2.22634312
92Amyloidosis (HP:0011034)2.21567201
93Pulmonary embolism (HP:0002204)2.20558058
94Irritability (HP:0000737)2.17093578
95Hyperactive renin-angiotensin system (HP:0000841)2.15913262
96Mucopolysacchariduria (HP:0008155)2.15231677
97Urinary glycosaminoglycan excretion (HP:0003541)2.15231677
98Vasculitis (HP:0002633)2.14929599
99Polycythemia (HP:0001901)2.13854436
100Cardiovascular calcification (HP:0011915)2.13430901
101Gastrointestinal infarctions (HP:0005244)2.12731908
102Lethargy (HP:0001254)2.11884030
103Pigmentary retinal degeneration (HP:0001146)2.10983981
104Thrombophlebitis (HP:0004418)2.10868911
105Meningitis (HP:0001287)2.10208012
106Dysostosis multiplex (HP:0000943)2.09895070
107Abnormality of vitamin B metabolism (HP:0004340)2.09307048
108Spastic diplegia (HP:0001264)2.08162077
109Abdominal distention (HP:0003270)2.07864377
110Pancreatitis (HP:0001733)2.07227975
111Menorrhagia (HP:0000132)2.06352821
112Joint swelling (HP:0001386)2.06318633
113Abnormality of urine glucose concentration (HP:0011016)2.06227972
114Glycosuria (HP:0003076)2.06227972
115Elevated erythrocyte sedimentation rate (HP:0003565)2.05593862
116Enlarged kidneys (HP:0000105)2.05013751
117Abnormality of polysaccharide metabolism (HP:0011012)2.03810944
118Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03810944
119Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03810944
120Ileus (HP:0002595)2.03014233
121Hydroxyprolinuria (HP:0003080)2.02801267
122Abnormality of proline metabolism (HP:0010907)2.02801267
123Increased cerebral lipofuscin (HP:0011813)2.02784196
124Hyperinsulinemic hypoglycemia (HP:0000825)2.02143163
125Nephritis (HP:0000123)1.99463659
126Reticulocytosis (HP:0001923)1.97844363
127Increased CSF protein (HP:0002922)1.96135315
128Encephalitis (HP:0002383)1.94221735
129Neonatal onset (HP:0003623)1.93747078
130Malnutrition (HP:0004395)1.91140976
131Pulmonary infiltrates (HP:0002113)1.91095226
132Hemorrhage of the eye (HP:0011885)1.90995057
133Purpura (HP:0000979)1.90928007
134Abnormal enzyme/coenzyme activity (HP:0012379)1.89198520
135Inflammation of the large intestine (HP:0002037)1.88832887
136Vomiting (HP:0002013)1.88632623
137Mediastinal lymphadenopathy (HP:0100721)1.86060943
138Cerebral edema (HP:0002181)1.85464384
139Symptomatic seizures (HP:0011145)1.84265780
140Abnormality of the gallbladder (HP:0005264)1.84203771
141Opisthotonus (HP:0002179)1.84200410
142Loss of speech (HP:0002371)1.84092880
143Cholecystitis (HP:0001082)1.84077218
144Abnormal gallbladder physiology (HP:0012438)1.84077218
145Rickets (HP:0002748)1.83795190
146Obstructive lung disease (HP:0006536)1.83633393
147Chronic obstructive pulmonary disease (HP:0006510)1.83633393
148Epistaxis (HP:0000421)1.83628476
149Hemoptysis (HP:0002105)1.82570097
150Elevated alkaline phosphatase (HP:0003155)1.81837333
151Bone pain (HP:0002653)1.81465223
152Status epilepticus (HP:0002133)1.81413920
153Cerebral palsy (HP:0100021)1.81302007
154Elevated hepatic transaminases (HP:0002910)1.80558412
155Pustule (HP:0200039)1.80080971
156Alkalosis (HP:0001948)1.79568616
157Abnormality of alkaline phosphatase activity (HP:0004379)1.79105042
158Gastrointestinal inflammation (HP:0004386)1.79011648
159Metabolic alkalosis (HP:0200114)1.75718024
160Recurrent fungal infections (HP:0002841)1.75295813
161Asymmetric septal hypertrophy (HP:0001670)1.74901985
162Nephrolithiasis (HP:0000787)1.74754042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.50420602
2ACVR1B4.18394534
3ERN13.73245202
4FGFR43.61286496
5TAOK33.36827275
6TYK23.34328656
7SIK13.32230642
8INSRR3.00447950
9RIPK42.88997307
10PRPF4B2.68225547
11MAP3K142.38621691
12TGFBR22.17754622
13TBK12.06751664
14FLT32.05187874
15JAK11.98819835
16MAP2K31.98381843
17IRAK31.95461934
18PRKG21.79985298
19MAP4K11.79799116
20MAPK151.72085723
21TRIB31.67234606
22CSF1R1.64382432
23JAK21.60589938
24MAPK111.59803905
25BLK1.59679599
26GRK61.49309804
27PTK61.49254647
28MAP3K21.46724611
29NEK91.45929380
30FES1.43074761
31PKN21.41587576
32PRKAA21.40139824
33MAP3K11.37673562
34EPHB11.34908062
35IKBKE1.34201587
36KDR1.29770110
37IKBKB1.29365410
38PIK3CG1.25841448
39ERBB41.25722610
40ZAP701.19749963
41MAP3K31.17900870
42CSK1.15617957
43KIT1.15002553
44MAP3K121.12752686
45JAK31.11954911
46TESK21.11700115
47KSR21.11022939
48MAP2K41.10443020
49FRK1.09417709
50PINK11.05079740
51MST1R1.00530685
52MATK0.98691311
53CHUK0.97562283
54FGFR30.96198149
55MAPK120.94038858
56HCK0.89147526
57MAP3K70.88994233
58EPHA30.87601860
59CDC42BPA0.85942501
60MAP3K100.85676713
61STK240.85610049
62FER0.82382214
63MYLK0.82178860
64CAMK1D0.80858368
65LATS10.80734698
66CDK60.80556216
67TIE10.80339117
68STK100.80165804
69IRAK40.78755628
70GRK10.76364978
71MAPK40.73683642
72MAP3K130.73444407
73TAOK10.73029561
74TESK10.72785616
75ITK0.72053179
76SGK30.70305434
77SYK0.70048165
78MAP2K60.66477351
79FGR0.66173565
80DYRK1B0.65281087
81DAPK20.64603297
82PKN10.64570649
83PRKAA10.61998097
84PTK20.61585234
85AKT30.61406961
86STK380.59004583
87SIK30.58594461
88TAOK20.58299093
89PRKCZ0.57561448
90YES10.57157089
91FYN0.56974802
92MAPK70.56775836
93TEC0.55937728
94MAP2K20.55531233
95SCYL20.55321937
96PRKACG0.55197420
97CAMKK20.54681987
98GSK3A0.54647957
99IGF1R0.54522396
100LYN0.54464408
101DDR20.54143127
102BMPR1B0.53854164
103TNK20.53775378
104BTK0.53685077
105ABL20.52839893
106PRKCQ0.51797299
107NLK0.50016485
108PDPK10.49472169
109EPHA20.48330032
110PDK10.47127650
111GRK70.45933070
112CAMK1G0.45242618
113PRKCD0.44904244
114PIM10.43896950
115ARAF0.43673121
116SGK20.42609819
117TRPM70.42442568
118MAP3K110.42099193
119PDK20.40132004
120RET0.40099584
121FGFR20.40059287
122PIK3CA0.39653274
123LCK0.39644057
124LRRK20.38413381
125TXK0.37729010
126ERBB20.37462969
127MET0.35637084
128MAP3K50.34797717
129EGFR0.34675849
130IRAK10.34538475
131STK40.33659426
132RIPK10.32439755
133BMPR20.30110651
134MAP3K60.29735508

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38726661
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31751396
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30592519
4Nitrogen metabolism_Homo sapiens_hsa009103.23324977
5Arginine biosynthesis_Homo sapiens_hsa002202.83407675
6Tryptophan metabolism_Homo sapiens_hsa003802.80605475
7Complement and coagulation cascades_Homo sapiens_hsa046102.72519449
8Caffeine metabolism_Homo sapiens_hsa002322.64823001
9Fatty acid degradation_Homo sapiens_hsa000712.49164521
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39302310
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38655158
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38436384
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31817638
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21654998
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16682949
16Peroxisome_Homo sapiens_hsa041462.10466808
17Staphylococcus aureus infection_Homo sapiens_hsa051502.04653148
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.97358455
19Chemical carcinogenesis_Homo sapiens_hsa052041.97012922
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93869605
21PPAR signaling pathway_Homo sapiens_hsa033201.88784760
22Propanoate metabolism_Homo sapiens_hsa006401.84163101
23Butanoate metabolism_Homo sapiens_hsa006501.83564269
24Histidine metabolism_Homo sapiens_hsa003401.78674097
25beta-Alanine metabolism_Homo sapiens_hsa004101.75366908
26Retinol metabolism_Homo sapiens_hsa008301.74754853
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.73459578
28Fatty acid metabolism_Homo sapiens_hsa012121.72907890
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61666562
30Selenocompound metabolism_Homo sapiens_hsa004501.59292226
31Bile secretion_Homo sapiens_hsa049761.53247202
32Sulfur metabolism_Homo sapiens_hsa009201.51951709
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47882037
34Phenylalanine metabolism_Homo sapiens_hsa003601.44907647
35ABC transporters_Homo sapiens_hsa020101.43464533
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42096477
37Mineral absorption_Homo sapiens_hsa049781.39722175
38Starch and sucrose metabolism_Homo sapiens_hsa005001.38058073
39Allograft rejection_Homo sapiens_hsa053301.35714942
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.28938415
41Fat digestion and absorption_Homo sapiens_hsa049751.26805243
42Tyrosine metabolism_Homo sapiens_hsa003501.26651096
43Autoimmune thyroid disease_Homo sapiens_hsa053201.25495582
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24968402
45Graft-versus-host disease_Homo sapiens_hsa053321.22868292
46Asthma_Homo sapiens_hsa053101.21016737
47Pyruvate metabolism_Homo sapiens_hsa006201.18588746
48Folate biosynthesis_Homo sapiens_hsa007901.18110222
49Steroid biosynthesis_Homo sapiens_hsa001001.17157948
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.12827884
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12443102
52Fatty acid elongation_Homo sapiens_hsa000621.10456508
53Protein digestion and absorption_Homo sapiens_hsa049741.09456125
54Vitamin digestion and absorption_Homo sapiens_hsa049771.04382004
55Biosynthesis of amino acids_Homo sapiens_hsa012300.99084432
56Carbon metabolism_Homo sapiens_hsa012000.95851403
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94972211
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93966078
59Vitamin B6 metabolism_Homo sapiens_hsa007500.93789840
60Type I diabetes mellitus_Homo sapiens_hsa049400.93117199
61Sulfur relay system_Homo sapiens_hsa041220.88567966
62Arginine and proline metabolism_Homo sapiens_hsa003300.88343869
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87895739
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84246400
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80044015
66Lysine degradation_Homo sapiens_hsa003100.77524524
67Glycerolipid metabolism_Homo sapiens_hsa005610.76273018
68Hematopoietic cell lineage_Homo sapiens_hsa046400.73477662
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.71079849
70Tuberculosis_Homo sapiens_hsa051520.67108550
71Antigen processing and presentation_Homo sapiens_hsa046120.66337685
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59882464
73Sphingolipid metabolism_Homo sapiens_hsa006000.53284352
74Glutathione metabolism_Homo sapiens_hsa004800.52905038
75Fatty acid biosynthesis_Homo sapiens_hsa000610.52876678
76One carbon pool by folate_Homo sapiens_hsa006700.49293668
77B cell receptor signaling pathway_Homo sapiens_hsa046620.49273177
78Viral myocarditis_Homo sapiens_hsa054160.49272378
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48723144
80Pentose phosphate pathway_Homo sapiens_hsa000300.48464493
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47750537
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45060075
83Other glycan degradation_Homo sapiens_hsa005110.44606985
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44496076
85Insulin resistance_Homo sapiens_hsa049310.43445896
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.42956780
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.41639898
88Metabolic pathways_Homo sapiens_hsa011000.40386656
89Prion diseases_Homo sapiens_hsa050200.39754818
90Rheumatoid arthritis_Homo sapiens_hsa053230.38764922
91Influenza A_Homo sapiens_hsa051640.38361611
92Galactose metabolism_Homo sapiens_hsa000520.38007680
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.37257851
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36842045
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36553231
96Primary immunodeficiency_Homo sapiens_hsa053400.36540546
97Fructose and mannose metabolism_Homo sapiens_hsa000510.35393858
98Ether lipid metabolism_Homo sapiens_hsa005650.34829182
99Phagosome_Homo sapiens_hsa041450.33991398
100Pancreatic secretion_Homo sapiens_hsa049720.33588100
101Chemokine signaling pathway_Homo sapiens_hsa040620.31246542
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.31171976
103TNF signaling pathway_Homo sapiens_hsa046680.30585755
104Amoebiasis_Homo sapiens_hsa051460.29523236
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29464763
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.28565511
107Prolactin signaling pathway_Homo sapiens_hsa049170.28200084
108Linoleic acid metabolism_Homo sapiens_hsa005910.27023385
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26788330
110Lysosome_Homo sapiens_hsa041420.25917131
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15686301
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08044729
113Renin-angiotensin system_Homo sapiens_hsa046140.05979480
114Glucagon signaling pathway_Homo sapiens_hsa049220.03951128
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02665563
116AMPK signaling pathway_Homo sapiens_hsa041520.02422788
117Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1282701
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1281255
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1152440
120Toxoplasmosis_Homo sapiens_hsa05145-0.1081115
121Insulin signaling pathway_Homo sapiens_hsa04910-0.0980641
122Osteoclast differentiation_Homo sapiens_hsa04380-0.0979338
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0868144
124Leishmaniasis_Homo sapiens_hsa05140-0.0835819
125Legionellosis_Homo sapiens_hsa05134-0.0700985
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0693379
127Hepatitis C_Homo sapiens_hsa05160-0.0446558
128Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0441457
129Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0321724
130NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0276458
131Pertussis_Homo sapiens_hsa05133-0.0116116

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