SLC46A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)9.14944032
2sphingoid metabolic process (GO:0046519)7.64068438
3adhesion of symbiont to host cell (GO:0044650)7.56982615
4virion attachment to host cell (GO:0019062)7.56982615
5hemidesmosome assembly (GO:0031581)6.99841406
6regulation of water loss via skin (GO:0033561)6.99620512
7establishment of skin barrier (GO:0061436)6.74850614
8antigen processing and presentation of endogenous antigen (GO:0019883)6.62401856
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.26184181
10negative regulation of cell killing (GO:0031342)6.26184181
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.12197797
12positive regulation by symbiont of host defense response (GO:0052509)6.03046412
13modulation by symbiont of host defense response (GO:0052031)6.03046412
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.03046412
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.03046412
16positive regulation by organism of defense response of other organism involved in symbiotic interact6.03046412
17modulation by symbiont of host immune response (GO:0052553)6.03046412
18positive regulation of gamma-delta T cell activation (GO:0046645)5.99832471
19adhesion of symbiont to host (GO:0044406)5.92196095
20regulation of natural killer cell differentiation (GO:0032823)5.88077930
21neutrophil activation involved in immune response (GO:0002283)5.77643002
22keratinocyte differentiation (GO:0030216)5.72430503
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46840514
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46840514
25keratinization (GO:0031424)5.46412749
26response to peptidoglycan (GO:0032494)5.35840635
27sphingosine metabolic process (GO:0006670)5.35347115
28diol metabolic process (GO:0034311)5.27407774
29macrophage activation involved in immune response (GO:0002281)5.14415993
30collecting duct development (GO:0072044)5.11033688
31regulation of glomerular filtration (GO:0003093)4.98331558
32cellular response to interferon-alpha (GO:0035457)4.89601841
33multicellular organismal water homeostasis (GO:0050891)4.88709951
34regulation of ruffle assembly (GO:1900027)4.85026552
35detection of external biotic stimulus (GO:0098581)4.78120791
36positive regulation of natural killer cell differentiation (GO:0032825)4.72621873
37negative regulation of interleukin-12 production (GO:0032695)4.72085662
38negative regulation of activin receptor signaling pathway (GO:0032926)4.68322737
39detection of bacterium (GO:0016045)4.60221704
40regulation of B cell receptor signaling pathway (GO:0050855)4.58148525
41detection of molecule of bacterial origin (GO:0032490)4.50425586
42epidermal cell differentiation (GO:0009913)4.50266656
43cellular extravasation (GO:0045123)4.48983797
44epidermis development (GO:0008544)4.45454414
45leukocyte aggregation (GO:0070486)4.43871652
46regulation of gamma-delta T cell activation (GO:0046643)4.33828256
47positive regulation of mast cell activation (GO:0033005)4.30277268
48detection of biotic stimulus (GO:0009595)4.24474014
49regulation of mast cell degranulation (GO:0043304)4.22489775
50negative regulation of lymphocyte mediated immunity (GO:0002707)4.21152674
51respiratory burst (GO:0045730)4.20366279
52renal system process involved in regulation of blood volume (GO:0001977)4.16882646
53regulation of transforming growth factor beta2 production (GO:0032909)4.11585880
54water homeostasis (GO:0030104)4.10258888
55microglial cell activation (GO:0001774)4.09890078
56intermediate filament organization (GO:0045109)4.08575746
57neutrophil activation (GO:0042119)4.08557506
58detection of other organism (GO:0098543)4.08528247
59regulation of interferon-beta biosynthetic process (GO:0045357)4.07673377
60leukocyte migration involved in inflammatory response (GO:0002523)3.99633211
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.97622858
62immunoglobulin mediated immune response (GO:0016064)3.96063498
63response to host immune response (GO:0052572)3.96057428
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.96057428
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.93930521
66ventricular cardiac muscle cell action potential (GO:0086005)3.93825273
67macrophage activation (GO:0042116)3.92510242
68regulation of mast cell activation involved in immune response (GO:0033006)3.91972110
69regulation of leukocyte degranulation (GO:0043300)3.85845743
70negative regulation of T cell mediated immunity (GO:0002710)3.83605436
71myeloid cell activation involved in immune response (GO:0002275)3.82424467
72negative regulation of leukocyte mediated immunity (GO:0002704)3.80808724
73regulation of cardioblast proliferation (GO:0003264)3.78760069
74regulation of secondary heart field cardioblast proliferation (GO:0003266)3.78760069
75negative regulation of erythrocyte differentiation (GO:0045647)3.78749055
76peptide cross-linking (GO:0018149)3.78298252
77granulocyte activation (GO:0036230)3.76138279
78regulation of mast cell activation (GO:0033003)3.75328625
79keratinocyte proliferation (GO:0043616)3.74748797
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71857960
81negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.69870751
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65650561
83response to host (GO:0075136)3.65650561
84response to host defenses (GO:0052200)3.65650561
85positive regulation of mast cell degranulation (GO:0043306)3.65107184
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.65107184
87neutrophil mediated immunity (GO:0002446)3.64714890
88gland morphogenesis (GO:0022612)3.61517621
89regulation of gamma-delta T cell differentiation (GO:0045586)3.53654396
90response to muramyl dipeptide (GO:0032495)3.50637088
91response to phenylpropanoid (GO:0080184)3.48354104
92cellular response to vitamin (GO:0071295)3.47570312
93negative regulation of kidney development (GO:0090185)3.43445067
94regulation of T cell tolerance induction (GO:0002664)3.43224672
95regulation of tolerance induction (GO:0002643)3.43165785
96positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.43046704
97positive regulation of antigen processing and presentation (GO:0002579)3.40053599
98regulation of somitogenesis (GO:0014807)3.37707878
99skin morphogenesis (GO:0043589)3.37689165
100regulation of regulated secretory pathway (GO:1903305)3.36410406
101hair follicle development (GO:0001942)3.35404001
102positive regulation of cellular amide metabolic process (GO:0034250)3.34530678
103hair cycle (GO:0042633)3.34179303
104molting cycle (GO:0042303)3.34179303
105skin development (GO:0043588)3.33252576
106positive regulation of Cdc42 GTPase activity (GO:0043089)3.33127742
107regulation of hair follicle development (GO:0051797)3.31234914
108response to interferon-alpha (GO:0035455)3.30516039
109production of molecular mediator involved in inflammatory response (GO:0002532)3.29239918
110* thymus development (GO:0048538)3.28888742
111cyclooxygenase pathway (GO:0019371)3.26885620
112negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26373230
113regulation of cell proliferation involved in kidney development (GO:1901722)3.23732309
114cell communication involved in cardiac conduction (GO:0086065)3.22985729
115renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.21774379
116B cell receptor signaling pathway (GO:0050853)3.18080345
117response to interleukin-15 (GO:0070672)3.17866268
118positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.16098530
119leukocyte degranulation (GO:0043299)3.14895251
120activated T cell proliferation (GO:0050798)3.13821592
121phospholipid scrambling (GO:0017121)3.13262841
122regulation of heart rate by cardiac conduction (GO:0086091)3.12559326
123negative regulation of phagocytosis (GO:0050765)3.11820433
124myeloid leukocyte mediated immunity (GO:0002444)3.11524355
125regulation of T-helper 2 cell differentiation (GO:0045628)3.11445860
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09154963
127regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05577759
128negative regulation of interferon-gamma production (GO:0032689)3.05102088
129regulation of transforming growth factor beta1 production (GO:0032908)3.04864334
130B cell mediated immunity (GO:0019724)3.04552696
131regulation of B cell differentiation (GO:0045577)3.03638728
132positive regulation of B cell differentiation (GO:0045579)3.02890941
133positive regulation of leukocyte degranulation (GO:0043302)2.99255242
134negative regulation of fibroblast apoptotic process (GO:2000270)2.96857142
135bone morphogenesis (GO:0060349)2.96124239
136interferon-gamma-mediated signaling pathway (GO:0060333)2.96021871
137defense response to protozoan (GO:0042832)2.94871580
138negative regulation of type 2 immune response (GO:0002829)2.94499946
139positive thymic T cell selection (GO:0045059)2.93514599
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93272879
141dendritic cell migration (GO:0036336)2.92749329
142positive regulation of regulated secretory pathway (GO:1903307)2.90423041
143regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89295697
144negative thymic T cell selection (GO:0045060)2.88614160
145regulation of phospholipase A2 activity (GO:0032429)2.88446335
146T cell selection (GO:0045058)2.88437750
147antigen processing and presentation via MHC class Ib (GO:0002475)2.88291313
148intermediate filament cytoskeleton organization (GO:0045104)2.88085678
149negative regulation of cytokine production involved in immune response (GO:0002719)2.87698702
150negative regulation of keratinocyte proliferation (GO:0010839)2.87387096
151negative regulation of interleukin-6 production (GO:0032715)2.86623523
152germinal center formation (GO:0002467)2.86232954
153negative regulation of cell fate specification (GO:0009996)2.85166251
154myeloid leukocyte activation (GO:0002274)2.84406350
155positive regulation of tolerance induction (GO:0002645)2.83743652
156CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.80989222
157cellular response to interleukin-15 (GO:0071350)2.80813433
158intermediate filament-based process (GO:0045103)2.79755728
159negative regulation of innate immune response (GO:0045824)2.79562400
160dendritic cell chemotaxis (GO:0002407)2.79263947
161regulation of natural killer cell mediated immunity (GO:0002715)2.78492128
162regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78492128
163extracellular matrix assembly (GO:0085029)2.76065759
164regulation of antigen processing and presentation (GO:0002577)2.75407954
165chemical homeostasis within a tissue (GO:0048875)2.74595680
166regulation of Cdc42 GTPase activity (GO:0043088)2.74114240
167positive regulation of Rho protein signal transduction (GO:0035025)2.72869487
168molting cycle process (GO:0022404)2.72246853
169hair cycle process (GO:0022405)2.72246853
170thymic T cell selection (GO:0045061)2.68543589
171long-chain fatty acid biosynthetic process (GO:0042759)2.59811023
172regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.59743309
173tight junction assembly (GO:0070830)2.59152544
174positive regulation of glomerulus development (GO:0090193)2.58387473
175regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58114727
176mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55526067
177mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55526067
178regulation of transforming growth factor beta production (GO:0071634)2.55274407
179regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.54833034
180regulation of hair cycle (GO:0042634)2.54650238
181epithelial cell fate commitment (GO:0072148)2.53043285
182positive regulation of mitochondrial membrane permeability (GO:0035794)2.52587427
183negative regulation of biomineral tissue development (GO:0070168)2.51978649
184regulation of dendritic cell antigen processing and presentation (GO:0002604)2.51302947
185planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50984604
186regulation of keratinocyte proliferation (GO:0010837)2.50603742
187sphingolipid biosynthetic process (GO:0030148)2.50578553
188cardiac conduction (GO:0061337)2.49405203
189atrioventricular valve morphogenesis (GO:0003181)2.49021190
190CD4-positive, alpha-beta T cell activation (GO:0035710)2.48218513
191intestinal epithelial cell development (GO:0060576)2.46812419
192desmosome organization (GO:0002934)11.9685468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.50675163
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.59439959
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.37023775
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60536612
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.60504549
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.44906950
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.39201480
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93920252
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88158363
10VDR_24763502_ChIP-Seq_THP-1_Human2.73977958
11VDR_21846776_ChIP-Seq_THP-1_Human2.71082150
12SPI1_23127762_ChIP-Seq_K562_Human2.69825123
13SPI1_23547873_ChIP-Seq_NB4_Human2.66385237
14SOX9_24532713_ChIP-Seq_HFSC_Mouse2.63498581
15RUNX_20019798_ChIP-Seq_JUKART_Human2.61458272
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.60474574
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.47338917
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40324509
19SCL_19346495_ChIP-Seq_HPC-7_Human2.40230101
20P63_26484246_Chip-Seq_KERATINOCYTES_Human2.39895210
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.37498322
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.37492519
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36194243
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31160804
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29760893
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.25129893
27* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22555205
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18550412
29MAF_26560356_Chip-Seq_TH1_Human2.17983477
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.17732078
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12397256
32KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05915279
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04248493
34MYB_26560356_Chip-Seq_TH2_Human2.02950961
35TP63_17297297_ChIP-ChIP_HaCaT_Human10.7773839
36VDR_24787735_ChIP-Seq_THP-1_Human1.99110127
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98100781
38MYC_22102868_ChIP-Seq_BL_Human1.97632136
39UTX_26944678_Chip-Seq_JUKART_Human1.94515149
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.91938061
41TCF7_22412390_ChIP-Seq_EML_Mouse1.91583201
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90336070
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.83869778
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79657264
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77641269
46MYB_26560356_Chip-Seq_TH1_Human1.76463229
47KDM2B_26808549_Chip-Seq_DND41_Human1.75358258
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.74742765
49SOX2_20726797_ChIP-Seq_SW620_Human1.74047802
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71578687
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71578687
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68870778
53* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67820600
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67483559
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66478348
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60183899
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.59408269
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59113917
59MAF_26560356_Chip-Seq_TH2_Human1.57375202
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55493274
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53122540
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.48781132
63* GATA3_27048872_Chip-Seq_THYMUS_Human1.48732375
64TP53_18474530_ChIP-ChIP_U2OS_Human1.47042452
65CJUN_26792858_Chip-Seq_BT549_Human1.46593285
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.45624087
67* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45449674
68AR_21572438_ChIP-Seq_LNCaP_Human1.44549705
69ZNF263_19887448_ChIP-Seq_K562_Human1.44346371
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43324507
71AHR_22903824_ChIP-Seq_MCF-7_Human1.43199186
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.42269712
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.39477574
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38464028
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.38288047
76TP63_23658742_ChIP-Seq_EP156T_Human1.38099314
77PU_27001747_Chip-Seq_BMDM_Mouse1.37980129
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36814724
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36228284
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.35866573
81* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35401219
82* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35131966
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32563150
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32284281
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31062339
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31062339
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30531063
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30104232
89* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29683230
90GATA1_19941826_ChIP-Seq_K562_Human1.28276856
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.25017813
92* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24913258
93* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24747337
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24053462
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23751227
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.23612424
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.21805286
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21586002
99* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21350678
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20118052
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19235120
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18971079
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18731882
104TP53_16413492_ChIP-PET_HCT116_Human1.17126331
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16072602
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15740833
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15473824
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15436665
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.15158812
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15000287
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13896826
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13891024
113RACK7_27058665_Chip-Seq_MCF-7_Human1.12742989
114GATA3_26560356_Chip-Seq_TH2_Human1.11518368
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10992435
116RXR_22108803_ChIP-Seq_LS180_Human1.08113197
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07337927
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07228654
119JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06989083
120GATA1_22025678_ChIP-Seq_K562_Human1.06573846
121* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06193519
122SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05864339
123SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05168014
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04982201
125BCAT_22108803_ChIP-Seq_LS180_Human1.04405495
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04385553
127GATA4_25053715_ChIP-Seq_YYC3_Human1.03808233
128JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03739255
129TP63_22573176_ChIP-Seq_HFKS_Human1.02819044
130CDX2_20551321_ChIP-Seq_CACO-2_Human1.02784157
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01957821
132BCL6_27268052_Chip-Seq_Bcells_Human1.01673307
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00931701
134KLF5_25053715_ChIP-Seq_YYC3_Human1.00787517
135BCOR_27268052_Chip-Seq_Bcells_Human1.00660073
136GATA2_19941826_ChIP-Seq_K562_Human1.00649381
137GATA3_24758297_ChIP-Seq_MCF-7_Human1.00212211
138* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00170983
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96854278
140PIAS1_25552417_ChIP-Seq_VCAP_Human0.96853447
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96085686
142STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95757737
143* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95329184
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95229327
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94958083
146MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92777912
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91734526
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91629592
149CLOCK_20551151_ChIP-Seq_293T_Human0.90757214
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89372159
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89372159
152SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89140309
153LXR_22292898_ChIP-Seq_THP-1_Human0.88197997
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88173423
155RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87668116
156ISL1_27105846_Chip-Seq_CPCs_Mouse0.87440948
157RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87411539
158* TCF4_22108803_ChIP-Seq_LS180_Human0.86631237
159NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84904074
160DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84318876
161TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83321112
162UBF1/2_26484160_Chip-Seq_HMECs_Human0.83151627
163CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82866620
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82586681
165EZH2_27294783_Chip-Seq_ESCs_Mouse0.82377892
166GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82093014
167SPI1_20517297_ChIP-Seq_HL60_Human0.81563541
168ERG_21242973_ChIP-ChIP_JURKAT_Human0.81532741
169BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81502109
170KDM2B_26808549_Chip-Seq_K562_Human0.81013655
171ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80065020
172FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80022400
173IRF8_22096565_ChIP-ChIP_GC-B_Human0.79257952
174FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79164015
175CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78826442
176WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77559708
177GATA6_25053715_ChIP-Seq_YYC3_Human0.77234271
178FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76814847
179P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76332617
180GATA2_21666600_ChIP-Seq_HMVEC_Human0.75621309
181HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75593810
182* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75568552
183RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75413858
184ATF3_27146783_Chip-Seq_COLON_Human0.74814376
185PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73879684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.84171839
2MP0002796_impaired_skin_barrier5.26231555
3MP0003724_increased_susceptibility_to4.72448980
4MP0010234_abnormal_vibrissa_follicle4.49962142
5MP0003941_abnormal_skin_development4.48172379
6MP0003436_decreased_susceptibility_to4.21812576
7MP0001346_abnormal_lacrimal_gland3.91551022
8MP0003453_abnormal_keratinocyte_physiol3.64240115
9MP0005275_abnormal_skin_tensile3.47443713
10MP0003303_peritoneal_inflammation3.46937419
11MP0000516_abnormal_urinary_system3.33651812
12MP0005367_renal/urinary_system_phenotyp3.33651812
13MP0002098_abnormal_vibrissa_morphology3.25324726
14MP0002419_abnormal_innate_immunity3.22810406
15MP0006082_CNS_inflammation3.07981778
16MP0002060_abnormal_skin_morphology3.01736687
17MP0005501_abnormal_skin_physiology2.97298621
18MP0005451_abnormal_body_composition2.93543348
19MP0005025_abnormal_response_to2.84733668
20MP0002009_preneoplasia2.74826823
21MP0010678_abnormal_skin_adnexa2.74018228
22MP0009785_altered_susceptibility_to2.72289530
23MP0001800_abnormal_humoral_immune2.70508334
24MP0005000_abnormal_immune_tolerance2.68747198
25MP0000579_abnormal_nail_morphology2.63728254
26MP0000383_abnormal_hair_follicle2.61673807
27MP0003300_gastrointestinal_ulcer2.57944851
28MP0001216_abnormal_epidermal_layer2.48751864
29MP0002723_abnormal_immune_serum2.44900424
30MP0002452_abnormal_antigen_presenting2.43681816
31MP0002420_abnormal_adaptive_immunity2.39576706
32MP0004381_abnormal_hair_follicle2.37715214
33MP0001819_abnormal_immune_cell2.36834991
34MP0000377_abnormal_hair_follicle2.34345772
35MP0003828_pulmonary_edema2.31707400
36MP0000685_abnormal_immune_system2.28846954
37MP0010771_integument_phenotype2.22973536
38MP0002148_abnormal_hypersensitivity_rea2.20553630
39MP0001533_abnormal_skeleton_physiology2.18440516
40MP0000647_abnormal_sebaceous_gland2.17689903
41MP0003172_abnormal_lysosome_physiology2.16854399
42MP0004947_skin_inflammation2.12908544
43MP0005464_abnormal_platelet_physiology2.09831397
44MP0000467_abnormal_esophagus_morphology2.03479615
45MP0008260_abnormal_autophagy2.02092102
46MP0002405_respiratory_system_inflammati2.00357758
47MP0005058_abnormal_lysosome_morphology1.94831475
48MP0002132_abnormal_respiratory_system1.83186660
49MP0000465_gastrointestinal_hemorrhage1.80376481
50MP0010386_abnormal_urinary_bladder1.79248031
51MP0002234_abnormal_pharynx_morphology1.73713298
52MP0000716_abnormal_immune_system1.72693286
53MP0003011_delayed_dark_adaptation1.69971190
54MP0002398_abnormal_bone_marrow1.68772552
55MP0000762_abnormal_tongue_morphology1.68510761
56MP0001845_abnormal_inflammatory_respons1.67524163
57MP0010155_abnormal_intestine_physiology1.64013940
58MP0000427_abnormal_hair_cycle1.60618104
59MP0003690_abnormal_glial_cell1.59428768
60MP0004883_abnormal_blood_vessel1.57987230
61MP0009333_abnormal_splenocyte_physiolog1.55177418
62MP0002277_abnormal_respiratory_mucosa1.54335224
63MP0002998_abnormal_bone_remodeling1.53159870
64MP0000689_abnormal_spleen_morphology1.46310212
65* MP0002722_abnormal_immune_system1.41145355
66MP0003566_abnormal_cell_adhesion1.40676022
67MP0008469_abnormal_protein_level1.40394821
68MP0000566_synostosis1.39945887
69MP0003075_altered_response_to1.38976599
70MP0000537_abnormal_urethra_morphology1.38471236
71MP0000538_abnormal_urinary_bladder1.35626283
72MP0002429_abnormal_blood_cell1.33761956
73MP0001835_abnormal_antigen_presentation1.32677441
74MP0003866_abnormal_defecation1.31992709
75MP0005023_abnormal_wound_healing1.28092112
76MP0001545_abnormal_hematopoietic_system1.27265312
77MP0005397_hematopoietic_system_phenotyp1.27265312
78MP0009764_decreased_sensitivity_to1.26736348
79* MP0000703_abnormal_thymus_morphology1.18627829
80MP0009931_abnormal_skin_appearance1.18528048
81MP0003705_abnormal_hypodermis_morpholog1.17775752
82MP0003183_abnormal_peptide_metabolism1.17439508
83MP0000343_altered_response_to1.15916828
84MP0001191_abnormal_skin_condition1.15906113
85MP0005164_abnormal_response_to1.14848698
86MP0000015_abnormal_ear_pigmentation1.14637304
87MP0000613_abnormal_salivary_gland1.14574239
88MP0001851_eye_inflammation1.14300832
89MP0005623_abnormal_meninges_morphology1.13662265
90MP0001849_ear_inflammation1.13323471
91MP0002938_white_spotting1.13312378
92MP0005166_decreased_susceptibility_to1.10910505
93MP0000733_abnormal_muscle_development1.10369166
94MP0004264_abnormal_extraembryonic_tissu1.04381808
95MP0005671_abnormal_response_to1.03751934
96MP0000604_amyloidosis1.03276929
97MP0002396_abnormal_hematopoietic_system1.01988404
98MP0002166_altered_tumor_susceptibility1.01242088
99MP0009250_abnormal_appendicular_skeleto0.99184541
100MP0003448_altered_tumor_morphology0.98664340
101MP0003763_abnormal_thymus_physiology0.96044776
102MP0005508_abnormal_skeleton_morphology0.95576724
103MP0001958_emphysema0.94706454
104MP0010030_abnormal_orbit_morphology0.94457461
105MP0004782_abnormal_surfactant_physiolog0.94255753
106MP0005075_abnormal_melanosome_morpholog0.93065989
107MP0004510_myositis0.92007090
108MP0005387_immune_system_phenotype0.91931130
109MP0001790_abnormal_immune_system0.91931130
110MP0001340_abnormal_eyelid_morphology0.90328749
111MP0004272_abnormal_basement_membrane0.89523972
112MP0001243_abnormal_dermal_layer0.88743776
113MP0000678_abnormal_parathyroid_gland0.86988729
114MP0002177_abnormal_outer_ear0.86554930
115MP0000367_abnormal_coat/_hair0.86389043
116MP0009379_abnormal_foot_pigmentation0.85948224
117MP0001348_abnormal_lacrimal_gland0.85242797
118MP0001986_abnormal_taste_sensitivity0.84396293
119MP0005388_respiratory_system_phenotype0.83971493
120MP0002133_abnormal_respiratory_system0.83971493
121MP0002249_abnormal_larynx_morphology0.82891867
122MP0002233_abnormal_nose_morphology0.82221069
123MP0002095_abnormal_skin_pigmentation0.81892155
124MP0001270_distended_abdomen0.81392039
125MP0006054_spinal_hemorrhage0.80418870
126MP0005310_abnormal_salivary_gland0.78569260
127MP0009763_increased_sensitivity_to0.78483176
128MP0003755_abnormal_palate_morphology0.78401499
129MP0002932_abnormal_joint_morphology0.78094001
130MP0004185_abnormal_adipocyte_glucose0.77950890
131MP0002876_abnormal_thyroid_physiology0.77171418
132MP0000858_altered_metastatic_potential0.75260542
133MP0005083_abnormal_biliary_tract0.73230767
134MP0001663_abnormal_digestive_system0.70896775
135MP0005174_abnormal_tail_pigmentation0.70674661
136MP0003091_abnormal_cell_migration0.70537496
137MP0002006_tumorigenesis0.70217794
138MP0003806_abnormal_nucleotide_metabolis0.70037981
139MP0003638_abnormal_response/metabolism_0.70026472
140MP0003795_abnormal_bone_structure0.69103026
141MP0000627_abnormal_mammary_gland0.66889793
142MP0002111_abnormal_tail_morphology0.66639520
143MP0003656_abnormal_erythrocyte_physiolo0.65173385
144MP0000249_abnormal_blood_vessel0.61772611
145MP0004130_abnormal_muscle_cell0.61131580
146MP0008874_decreased_physiological_sensi0.61127548
147MP0000920_abnormal_myelination0.60964365
148MP0000490_abnormal_crypts_of0.60811891
149MP0003385_abnormal_body_wall0.60473980
150MP0003329_amyloid_beta_deposits0.60032037
151MP0000049_abnormal_middle_ear0.59593313
152MP0001177_atelectasis0.59587476
153MP0003191_abnormal_cellular_cholesterol0.59354723
154MP0009384_cardiac_valve_regurgitation0.58581717
155MP0002933_joint_inflammation0.57530226
156MP0000681_abnormal_thyroid_gland0.57272173
157MP0008789_abnormal_olfactory_epithelium0.56999975
158MP0005076_abnormal_cell_differentiation0.56951975
159MP0000569_abnormal_digit_pigmentation0.56486147
160MP0003045_fibrosis0.55367484
161MP0009765_abnormal_xenobiotic_induced0.55069140
162MP0000470_abnormal_stomach_morphology0.52606759
163MP0008004_abnormal_stomach_pH0.52249303
164MP0001853_heart_inflammation0.52200481
165MP0005390_skeleton_phenotype0.51969950
166MP0009278_abnormal_bone_marrow0.51888402
167MP0001873_stomach_inflammation0.50986830
168MP0000163_abnormal_cartilage_morphology0.43901120
169MP0003935_abnormal_craniofacial_develop0.43768030
170MP0001299_abnormal_eye_distance/0.43423868
171MP0002697_abnormal_eye_size0.42294496
172MP0004019_abnormal_vitamin_homeostasis0.41716303
173MP0005503_abnormal_tendon_morphology0.41217500

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)8.81843540
2Recurrent abscess formation (HP:0002722)6.28202919
3Lip pit (HP:0100267)6.26562593
4Recurrent bacterial skin infections (HP:0005406)6.25365625
5Abnormality of macrophages (HP:0004311)5.83606033
6Onycholysis (HP:0001806)5.79209384
7Hypotrichosis (HP:0001006)5.76500579
8Plantar hyperkeratosis (HP:0007556)5.73048815
9Alacrima (HP:0000522)5.60535266
10Nasolacrimal duct obstruction (HP:0000579)5.53602285
11Woolly hair (HP:0002224)5.51419372
12Myositis (HP:0100614)5.44870203
13Recurrent gram-negative bacterial infections (HP:0005420)5.26536718
14Orchitis (HP:0100796)5.10060238
15Abnormality of the lacrimal duct (HP:0011481)5.04542435
16Natal tooth (HP:0000695)5.01045777
17Milia (HP:0001056)4.84308807
18Optic neuritis (HP:0100653)4.81733702
19Retrobulbar optic neuritis (HP:0100654)4.81733702
20Palmoplantar hyperkeratosis (HP:0000972)4.80667537
21Decreased lacrimation (HP:0000633)4.72154800
22Fragile nails (HP:0001808)4.51530199
23Parakeratosis (HP:0001036)4.50606028
24Palmar hyperkeratosis (HP:0010765)4.50437680
25Stomatitis (HP:0010280)4.47364816
26Abnormality of the nasolacrimal system (HP:0000614)4.35731521
27Microretrognathia (HP:0000308)4.35360332
28Mixed hearing impairment (HP:0000410)4.29315379
29Elevated erythrocyte sedimentation rate (HP:0003565)4.27455659
30Increased IgE level (HP:0003212)4.25539394
31Recurrent skin infections (HP:0001581)4.17901641
32Congenital ichthyosiform erythroderma (HP:0007431)4.16605069
33Periauricular skin pits (HP:0100277)4.09339332
34Preauricular pit (HP:0004467)4.09339332
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.05934779
36Abnormality of nail color (HP:0100643)4.02475003
37Recurrent fungal infections (HP:0002841)3.97998255
38Pili torti (HP:0003777)3.96002782
39Mediastinal lymphadenopathy (HP:0100721)3.92699362
40Abnormality of the axillary hair (HP:0100134)3.90967509
41Abnormality of secondary sexual hair (HP:0009888)3.90967509
42Obstructive lung disease (HP:0006536)3.87195115
43Chronic obstructive pulmonary disease (HP:0006510)3.87195115
44Advanced eruption of teeth (HP:0006288)3.84286175
45Spontaneous hematomas (HP:0007420)3.78775118
46Atrophic scars (HP:0001075)3.75760315
47Skin pits (HP:0100276)3.73449051
48Gastrointestinal infarctions (HP:0005244)3.68134188
49Meningitis (HP:0001287)3.63490058
50Urticaria (HP:0001025)3.58780929
51Keratoconjunctivitis sicca (HP:0001097)3.58294336
52Recurrent cutaneous fungal infections (HP:0011370)3.52465257
53Chronic mucocutaneous candidiasis (HP:0002728)3.52465257
54Nail dystrophy (HP:0008404)3.50959142
55Gingivitis (HP:0000230)3.49365651
56Abnormality of the gastric mucosa (HP:0004295)3.48812892
57Sparse scalp hair (HP:0002209)3.46060122
58Ventricular fibrillation (HP:0001663)3.44843973
59Abnormal delayed hypersensitivity skin test (HP:0002963)3.44359649
60Scapular winging (HP:0003691)3.36946487
61Prolonged bleeding time (HP:0003010)3.34384648
62Erythema (HP:0010783)3.34020538
63Encephalitis (HP:0002383)3.30334231
64Keratoconjunctivitis (HP:0001096)3.29157785
65Ventricular tachycardia (HP:0004756)3.27793437
66Amyloidosis (HP:0011034)3.17181231
67Sparse eyelashes (HP:0000653)3.13093304
68Abnormal blistering of the skin (HP:0008066)3.08236883
69Vasculitis (HP:0002633)3.07258438
70Increased cerebral lipofuscin (HP:0011813)3.05875750
71Ectropion (HP:0000656)3.03356660
72Oligodontia (HP:0000677)3.02166960
73Abnormality of glycolipid metabolism (HP:0010969)3.00631165
74Abnormality of liposaccharide metabolism (HP:0010968)3.00631165
75Abnormality of glycosphingolipid metabolism (HP:0004343)3.00631165
76Cellulitis (HP:0100658)2.96306008
77Episodic fever (HP:0001954)2.92885894
78Gingival bleeding (HP:0000225)2.91542019
79Hemoptysis (HP:0002105)2.91048608
80Chest pain (HP:0100749)2.85209727
81Pulmonary infiltrates (HP:0002113)2.83804315
82Abnormality of the antihelix (HP:0009738)2.81894798
83Epistaxis (HP:0000421)2.70942789
84Arterial thrombosis (HP:0004420)2.69964928
85Hypochromic microcytic anemia (HP:0004840)2.68006504
86T lymphocytopenia (HP:0005403)2.64495591
87Erythroderma (HP:0001019)2.63708591
88Petechiae (HP:0000967)2.63510554
89Pterygium (HP:0001059)2.62855375
90Leukocytosis (HP:0001974)2.61965755
91Recurrent viral infections (HP:0004429)2.59599090
92Hypoplasia of dental enamel (HP:0006297)2.59021734
93Purpura (HP:0000979)2.58909845
94Pulmonary embolism (HP:0002204)2.58062774
95Peritonitis (HP:0002586)2.56951495
96Inflammation of the large intestine (HP:0002037)2.55572655
97Abnormality of T cell number (HP:0011839)2.49607253
98Aplasia cutis congenita (HP:0001057)2.47930073
99Loss of speech (HP:0002371)2.47610722
100Hypochromic anemia (HP:0001931)2.47197405
101Gastrointestinal inflammation (HP:0004386)2.45224276
102Osteomyelitis (HP:0002754)2.44552689
103Selective tooth agenesis (HP:0001592)2.44438474
104Anhidrosis (HP:0000970)2.41710053
105Anorexia (HP:0002039)2.39369932
106Hypohidrosis (HP:0000966)2.38428804
107Hypergammaglobulinemia (HP:0010702)2.37027517
108Palmoplantar keratoderma (HP:0000982)2.36683905
109Abnormal hair laboratory examination (HP:0003328)2.35687884
110Dysostosis multiplex (HP:0000943)2.34958036
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.29280510
112Popliteal pterygium (HP:0009756)2.26893056
113Sepsis (HP:0100806)2.24687903
114Panhypogammaglobulinemia (HP:0003139)2.23693490
115Corneal erosion (HP:0200020)2.18277229
116Hematochezia (HP:0002573)2.17727825
117Fragile skin (HP:0001030)2.16829561
118Vacuolated lymphocytes (HP:0001922)2.16440524
119Disinhibition (HP:0000734)2.15147215
120Intellectual disability, moderate (HP:0002342)2.13751126
121Hydroxyprolinuria (HP:0003080)2.13144773
122Abnormality of proline metabolism (HP:0010907)2.13144773
123Increased serum ferritin (HP:0003281)2.11501527
124Abnormality of T cells (HP:0002843)2.11409969
125Skin ulcer (HP:0200042)2.10901401
126Increased IgM level (HP:0003496)2.10441010
127Colitis (HP:0002583)2.10140341
128Prostate neoplasm (HP:0100787)2.07770382
129Pruritus (HP:0000989)2.07031918
130Esophageal atresia (HP:0002032)2.06252576
131Chronic otitis media (HP:0000389)2.05937736
132Abnormality of the pleura (HP:0002103)2.05930652
133Hypoplastic labia majora (HP:0000059)2.05356062
134Hepatosplenomegaly (HP:0001433)2.05341892
135Vertigo (HP:0002321)2.04534002
136Pustule (HP:0200039)2.03980590
137Systemic lupus erythematosus (HP:0002725)2.03732084
138Testicular atrophy (HP:0000029)2.03208818
139Granulocytopenia (HP:0001913)2.02688717
140Abnormal platelet volume (HP:0011876)2.02292603
141Hyporeflexia of lower limbs (HP:0002600)2.02140500
142Acanthosis nigricans (HP:0000956)2.01346729
143Premature loss of primary teeth (HP:0006323)1.99286859
144Eczematoid dermatitis (HP:0000976)1.99104933
145Acne (HP:0001061)1.97558419
146Periodontitis (HP:0000704)1.95577132
147Malnutrition (HP:0004395)1.95317508
148Microcytic anemia (HP:0001935)1.94468231
149Dehydration (HP:0001944)1.93538656
150Absent hair (HP:0002298)1.93436700
151Polyneuropathy (HP:0001271)1.92817253
152Abnormality of the peritoneum (HP:0002585)1.92284348
153Hypodontia (HP:0000668)1.91604105
154Abnormality of small intestinal villus morphology (HP:0011472)1.90226982
155Villous atrophy (HP:0011473)1.90226982
156Absent eyebrow (HP:0002223)1.89983745
157Ventricular arrhythmia (HP:0004308)1.89322128
158Abnormality of the endocardium (HP:0004306)1.88948388
159Glomerulopathy (HP:0100820)1.88563511
160Abnormality of iron homeostasis (HP:0011031)1.88471657
161Tapered finger (HP:0001182)1.87446744
162Abnormality of the labia majora (HP:0012881)1.85095864
163Ureteral stenosis (HP:0000071)1.85092073
164Gangrene (HP:0100758)1.84566689
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83815111
166Absent eyelashes (HP:0000561)1.83706289
167Lymphopenia (HP:0001888)1.83328799
168Slow saccadic eye movements (HP:0000514)1.83239894
169Abnormality of polysaccharide metabolism (HP:0011012)1.82324382
170Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82324382
171Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82324382
172Ureteral obstruction (HP:0006000)1.81596475
173Keratitis (HP:0000491)1.80813478
174Hypermelanotic macule (HP:0001034)1.78967639
175Polycythemia (HP:0001901)1.78957556
176Neonatal death (HP:0003811)1.78481765
177Dry hair (HP:0011359)1.76725367
178Cheilitis (HP:0100825)1.75951045
179Autoimmune thrombocytopenia (HP:0001973)1.75289178
180Curly hair (HP:0002212)1.73483714
181Malignant hyperthermia (HP:0002047)1.72970178
182Hoarse voice (HP:0001609)1.65023883
183Abnormality of the shoulder girdle musculature (HP:0001435)1.63332857
184Premature skin wrinkling (HP:0100678)1.63196801
185Sudden cardiac death (HP:0001645)1.61886507
186Morphological abnormality of the middle ear (HP:0008609)1.61761490
187Thick nail (HP:0001805)1.58259778
188Amelogenesis imperfecta (HP:0000705)1.57105907
189Interstitial pulmonary disease (HP:0006530)1.57019450
190Abnormality of the neuromuscular junction (HP:0003398)1.55559804
191Fatigable weakness (HP:0003473)1.55559804
192Anonychia (HP:0001798)1.54861796
193Dry skin (HP:0000958)1.53920538
194Ridged nail (HP:0001807)1.53872142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.54801482
2MAPK154.47704769
3MST44.25625299
4FER3.75925160
5MAP4K13.15341245
6RPS6KB22.98840741
7MAPKAPK32.96201320
8MAP2K32.93870795
9CSK2.87817354
10PRPF4B2.87337613
11FES2.70714306
12MAP3K32.65946953
13TNK22.61781040
14IRAK42.59907690
15MAP3K22.43614707
16ZAP702.13280000
17TTN2.11224883
18ERN12.01187313
19FGR2.00273396
20PTK62.00073512
21FGFR41.96354787
22EPHB11.92516360
23MAP3K141.90422880
24GRK61.89489672
25BCR1.74319241
26EPHB21.70509295
27HCK1.69683633
28TAOK11.67472016
29SYK1.64476418
30TYK21.56676676
31DYRK1B1.55331935
32MAP3K111.49026049
33EPHA31.46676276
34MAPKAPK51.46322782
35TXK1.42293173
36MST1R1.41320695
37ITK1.39784868
38ERBB31.38865329
39CSF1R1.34695269
40LYN1.32647358
41TSSK61.32456929
42RIPK41.31142602
43BTK1.30680413
44YES11.28070488
45LMTK21.27999144
46SIK31.27010522
47ERBB21.26618255
48LATS21.26005971
49GRK11.25873109
50KSR21.21622780
51FGFR21.19486846
52MARK21.18562863
53LCK1.14670091
54MAP3K61.14445918
55IKBKE1.13853088
56KIT1.10419429
57MARK31.08856620
58TAOK31.08117326
59MAPKAPK21.07433963
60TBK11.02969568
61MATK1.00246424
62STK38L0.99779549
63PDK10.98440134
64PDPK10.97864625
65JAK10.95190885
66TRPM70.95083493
67MAPK120.94960874
68PRKD20.93863933
69EEF2K0.93851992
70PIK3CG0.92270725
71TRIB30.90844363
72FGFR30.90029720
73JAK20.89390360
74MAPK70.88848274
75STK100.86606342
76LRRK20.83865900
77CHUK0.83723748
78PIM20.83612363
79TGFBR20.81528820
80TESK10.81482693
81PTK20.80659858
82SIK10.79839191
83MAP2K20.79196883
84TAOK20.77793919
85PAK20.76965172
86CLK10.75479135
87CDC42BPA0.74193182
88FYN0.73895523
89CAMKK20.73715462
90IRAK20.73369413
91MAP2K40.71201460
92CDK30.71134254
93MAP3K70.70968820
94CAMK2G0.70911614
95IRAK10.69774775
96RIPK10.68027866
97SGK30.67677169
98GRK70.67299205
99CDK190.65719923
100BMPR20.64619597
101PKN10.63533358
102STK110.60303967
103TGFBR10.59824813
104SIK20.58324318
105PRKCE0.56627929
106TESK20.55411066
107FRK0.54880808
108RPS6KA10.54679643
109TEC0.52336390
110PAK30.50647782
111IRAK30.49409079
112MAP3K50.48968191
113CAMKK10.48615416
114IKBKB0.48513422
115PTK2B0.47498141
116NLK0.47386834
117RET0.47312954
118STK30.47126980
119SGK20.47094537
120JAK30.46711223
121PRKCQ0.46568882
122MAP3K130.46511370
123DMPK0.45919484
124FGFR10.45886927
125SMG10.44425914
126DAPK20.44354576
127KSR10.43012158
128MOS0.42133824
129PDGFRB0.41708569
130MAP3K10.41593562
131CSNK1D0.41395124
132CAMK1D0.41030246
133PRKD10.41019376
134STK380.40350879
135ROCK20.38966531
136PIK3CA0.38629408
137NUAK10.38284139
138RPS6KA20.37593242
139HIPK20.37081309
140SRC0.36820043
141NEK60.35920116
142RPS6KL10.35527936
143RPS6KC10.35527936
144MAP3K90.34809306
145DDR20.34278914
146MAP2K60.33127513
147BLK0.32848556
148RPS6KA60.32111549
149RAF10.31669557
150RPS6KA50.31575322
151PRKCI0.31502775
152NME10.31233168
153GRK50.30587246
154PDGFRA0.28018447
155MYLK0.27425140
156ADRBK10.27408972
157ABL10.27360589
158CAMK2B0.26713433
159MAPK30.26602751
160GSK3A0.26329716

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006003.63187233
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.84818227
3Antigen processing and presentation_Homo sapiens_hsa046122.56956462
4Linoleic acid metabolism_Homo sapiens_hsa005912.49916821
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39612419
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.21291526
7Arachidonic acid metabolism_Homo sapiens_hsa005902.17907301
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14197201
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12341066
10Allograft rejection_Homo sapiens_hsa053302.11660622
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09281393
12B cell receptor signaling pathway_Homo sapiens_hsa046622.08687594
13Phenylalanine metabolism_Homo sapiens_hsa003602.08114086
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06340015
15Histidine metabolism_Homo sapiens_hsa003402.00834769
16Autoimmune thyroid disease_Homo sapiens_hsa053201.97211121
17Other glycan degradation_Homo sapiens_hsa005111.87211427
18Malaria_Homo sapiens_hsa051441.79621567
19ECM-receptor interaction_Homo sapiens_hsa045121.71876839
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70868839
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67565038
22Ether lipid metabolism_Homo sapiens_hsa005651.67355890
23Toxoplasmosis_Homo sapiens_hsa051451.65786499
24Acute myeloid leukemia_Homo sapiens_hsa052211.61376710
25Hippo signaling pathway_Homo sapiens_hsa043901.55217322
26Type I diabetes mellitus_Homo sapiens_hsa049401.54521988
27Viral myocarditis_Homo sapiens_hsa054161.46264361
28Adherens junction_Homo sapiens_hsa045201.44524709
29Asthma_Homo sapiens_hsa053101.41170323
30Tight junction_Homo sapiens_hsa045301.30588304
31Notch signaling pathway_Homo sapiens_hsa043301.29920515
32Platelet activation_Homo sapiens_hsa046111.29840104
33Sphingolipid signaling pathway_Homo sapiens_hsa040711.24923098
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24916418
35Basal cell carcinoma_Homo sapiens_hsa052171.24475409
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24392021
37Osteoclast differentiation_Homo sapiens_hsa043801.20716937
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.20593264
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.16526069
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14318766
41Amoebiasis_Homo sapiens_hsa051461.14023161
42Pertussis_Homo sapiens_hsa051331.13762759
43Axon guidance_Homo sapiens_hsa043601.13372116
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12720669
45Rheumatoid arthritis_Homo sapiens_hsa053231.11905244
46Non-small cell lung cancer_Homo sapiens_hsa052231.10438727
47Leishmaniasis_Homo sapiens_hsa051401.09545669
48Hepatitis C_Homo sapiens_hsa051601.07847490
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.06628359
50Small cell lung cancer_Homo sapiens_hsa052221.05646429
51Salmonella infection_Homo sapiens_hsa051321.04655648
52TNF signaling pathway_Homo sapiens_hsa046681.04243451
53Proteoglycans in cancer_Homo sapiens_hsa052051.03638071
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.03324427
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02348515
56Hepatitis B_Homo sapiens_hsa051611.02146815
57ABC transporters_Homo sapiens_hsa020101.01598009
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.00651532
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00138969
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99967679
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95807513
62African trypanosomiasis_Homo sapiens_hsa051430.95243977
63Fatty acid elongation_Homo sapiens_hsa000620.94251321
64Shigellosis_Homo sapiens_hsa051310.92872873
65Pancreatic cancer_Homo sapiens_hsa052120.91072819
66Tyrosine metabolism_Homo sapiens_hsa003500.90974628
67Caffeine metabolism_Homo sapiens_hsa002320.90059796
68Renal cell carcinoma_Homo sapiens_hsa052110.87599028
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87020967
70Lysosome_Homo sapiens_hsa041420.86567112
71Chronic myeloid leukemia_Homo sapiens_hsa052200.86464368
72Influenza A_Homo sapiens_hsa051640.84144410
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.83876616
74Endocytosis_Homo sapiens_hsa041440.83532620
75Focal adhesion_Homo sapiens_hsa045100.83481887
76Bladder cancer_Homo sapiens_hsa052190.82239869
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.81736277
78beta-Alanine metabolism_Homo sapiens_hsa004100.80408781
79Sulfur metabolism_Homo sapiens_hsa009200.79525056
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76895554
81Staphylococcus aureus infection_Homo sapiens_hsa051500.75530089
82Collecting duct acid secretion_Homo sapiens_hsa049660.74645530
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74370951
84Melanogenesis_Homo sapiens_hsa049160.73953359
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73125647
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71767453
87Choline metabolism in cancer_Homo sapiens_hsa052310.69352598
88Estrogen signaling pathway_Homo sapiens_hsa049150.68607906
89Dorso-ventral axis formation_Homo sapiens_hsa043200.68165769
90Endometrial cancer_Homo sapiens_hsa052130.67131097
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66292160
92Rap1 signaling pathway_Homo sapiens_hsa040150.66208306
93Insulin resistance_Homo sapiens_hsa049310.66044546
94Pathways in cancer_Homo sapiens_hsa052000.65066995
95Chemical carcinogenesis_Homo sapiens_hsa052040.64726704
96VEGF signaling pathway_Homo sapiens_hsa043700.64698373
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64216475
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63726263
99Primary immunodeficiency_Homo sapiens_hsa053400.63265655
100Legionellosis_Homo sapiens_hsa051340.63073338
101Hedgehog signaling pathway_Homo sapiens_hsa043400.62905625
102ErbB signaling pathway_Homo sapiens_hsa040120.62273634
103Vitamin digestion and absorption_Homo sapiens_hsa049770.61127898
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60358622
105Apoptosis_Homo sapiens_hsa042100.60270053
106FoxO signaling pathway_Homo sapiens_hsa040680.59566671
107Retinol metabolism_Homo sapiens_hsa008300.59224793
108Graft-versus-host disease_Homo sapiens_hsa053320.58864702
109Mineral absorption_Homo sapiens_hsa049780.58820579
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58761462
111Gastric acid secretion_Homo sapiens_hsa049710.58401290
112Tuberculosis_Homo sapiens_hsa051520.58361058
113GnRH signaling pathway_Homo sapiens_hsa049120.57798358
114Inositol phosphate metabolism_Homo sapiens_hsa005620.55447471
115HIF-1 signaling pathway_Homo sapiens_hsa040660.55398608
116Herpes simplex infection_Homo sapiens_hsa051680.54733600
117Measles_Homo sapiens_hsa051620.53254157
118mTOR signaling pathway_Homo sapiens_hsa041500.52961959
119Colorectal cancer_Homo sapiens_hsa052100.52944597
120T cell receptor signaling pathway_Homo sapiens_hsa046600.50793647
121TGF-beta signaling pathway_Homo sapiens_hsa043500.50733829
122Ras signaling pathway_Homo sapiens_hsa040140.50463159
123Epstein-Barr virus infection_Homo sapiens_hsa051690.50326309
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.49966834
125Prolactin signaling pathway_Homo sapiens_hsa049170.49940267
126MAPK signaling pathway_Homo sapiens_hsa040100.48934343
127Prostate cancer_Homo sapiens_hsa052150.48698885
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48578398
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48222328
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48148615
131Chemokine signaling pathway_Homo sapiens_hsa040620.47917369
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47559086
133MicroRNAs in cancer_Homo sapiens_hsa052060.46494649
134Wnt signaling pathway_Homo sapiens_hsa043100.46187094
135HTLV-I infection_Homo sapiens_hsa051660.45927802
136Type II diabetes mellitus_Homo sapiens_hsa049300.44707924
137Viral carcinogenesis_Homo sapiens_hsa052030.43166522
138Hematopoietic cell lineage_Homo sapiens_hsa046400.42507518
139Regulation of autophagy_Homo sapiens_hsa041400.42099963
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41911689
141Melanoma_Homo sapiens_hsa052180.41516566
142Pancreatic secretion_Homo sapiens_hsa049720.41462277
143Protein digestion and absorption_Homo sapiens_hsa049740.41206123
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.40716253
145Phagosome_Homo sapiens_hsa041450.40560892
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.40457924
147Long-term potentiation_Homo sapiens_hsa047200.39108701
148Vibrio cholerae infection_Homo sapiens_hsa051100.38909657
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38855769
150PPAR signaling pathway_Homo sapiens_hsa033200.38777862
151Cocaine addiction_Homo sapiens_hsa050300.37749480

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