SLC46A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.62370484
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.89306482
3L-phenylalanine catabolic process (GO:0006559)5.89306482
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.85074648
5L-phenylalanine metabolic process (GO:0006558)5.85074648
6cysteine metabolic process (GO:0006534)5.69975066
7aromatic amino acid family catabolic process (GO:0009074)5.39973908
8high-density lipoprotein particle remodeling (GO:0034375)5.35661883
9regulation of cholesterol esterification (GO:0010872)5.30309378
10serine family amino acid catabolic process (GO:0009071)5.22370697
11homocysteine metabolic process (GO:0050667)5.18714215
12intestinal cholesterol absorption (GO:0030299)5.11284901
13sulfur amino acid catabolic process (GO:0000098)5.04536362
14indole-containing compound catabolic process (GO:0042436)5.02306651
15indolalkylamine catabolic process (GO:0046218)5.02306651
16tryptophan catabolic process (GO:0006569)5.02306651
17regulation of plasminogen activation (GO:0010755)4.98867423
18reverse cholesterol transport (GO:0043691)4.94114371
19glyoxylate metabolic process (GO:0046487)4.91027174
20kynurenine metabolic process (GO:0070189)4.89715018
21negative regulation of sterol transport (GO:0032372)4.88009080
22negative regulation of cholesterol transport (GO:0032375)4.88009080
23regulation of triglyceride catabolic process (GO:0010896)4.85212996
24urea cycle (GO:0000050)4.80963536
25urea metabolic process (GO:0019627)4.80963536
26tryptophan metabolic process (GO:0006568)4.76139961
27phospholipid efflux (GO:0033700)4.75020830
28epoxygenase P450 pathway (GO:0019373)4.67951433
29bile acid biosynthetic process (GO:0006699)4.63853676
30alpha-linolenic acid metabolic process (GO:0036109)4.61933154
31protein-lipid complex remodeling (GO:0034368)4.59444140
32macromolecular complex remodeling (GO:0034367)4.59444140
33plasma lipoprotein particle remodeling (GO:0034369)4.59444140
34amino-acid betaine metabolic process (GO:0006577)4.57845955
35serine family amino acid biosynthetic process (GO:0009070)4.53316144
36drug catabolic process (GO:0042737)4.51291135
37glycine metabolic process (GO:0006544)4.50665281
38intestinal absorption (GO:0050892)4.49618259
39serine family amino acid metabolic process (GO:0009069)4.47444387
40omega-hydroxylase P450 pathway (GO:0097267)4.47341402
41nitrogen cycle metabolic process (GO:0071941)4.44766455
42positive regulation of triglyceride lipase activity (GO:0061365)4.37204286
43positive regulation of lipoprotein lipase activity (GO:0051006)4.37204286
44cholesterol efflux (GO:0033344)4.35824591
45aromatic amino acid family metabolic process (GO:0009072)4.34854704
46cellular glucuronidation (GO:0052695)4.34634176
47regulation of protein activation cascade (GO:2000257)4.23124229
48negative regulation of fibrinolysis (GO:0051918)4.15823783
49flavonoid metabolic process (GO:0009812)4.14019933
50lysine catabolic process (GO:0006554)4.11966331
51lysine metabolic process (GO:0006553)4.11966331
52bile acid metabolic process (GO:0008206)4.11113201
53fructose metabolic process (GO:0006000)4.08804898
54plasma lipoprotein particle assembly (GO:0034377)4.06543049
55alpha-amino acid catabolic process (GO:1901606)4.05020625
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.04027983
57regulation of complement activation (GO:0030449)4.00091471
58glucuronate metabolic process (GO:0019585)3.99151477
59uronic acid metabolic process (GO:0006063)3.99151477
60triglyceride homeostasis (GO:0070328)3.98357235
61acylglycerol homeostasis (GO:0055090)3.98357235
62protein carboxylation (GO:0018214)3.98181096
63peptidyl-glutamic acid carboxylation (GO:0017187)3.98181096
64complement activation, alternative pathway (GO:0006957)3.95371147
65bile acid and bile salt transport (GO:0015721)3.94456644
66regulation of fibrinolysis (GO:0051917)3.93625526
67nucleoside transmembrane transport (GO:1901642)3.92982214
68cholesterol homeostasis (GO:0042632)3.87768165
69cellular amino acid catabolic process (GO:0009063)3.85278708
70cellular modified amino acid catabolic process (GO:0042219)3.84489545
71regulation of bile acid biosynthetic process (GO:0070857)3.83069022
72sterol homeostasis (GO:0055092)3.80830183
73glutamate metabolic process (GO:0006536)3.79912218
74cellular ketone body metabolic process (GO:0046950)3.71895383
75tyrosine metabolic process (GO:0006570)3.71567544
76plasma lipoprotein particle clearance (GO:0034381)3.70829483
77L-serine metabolic process (GO:0006563)3.68841231
78very-low-density lipoprotein particle assembly (GO:0034379)3.66757131
79protein-lipid complex assembly (GO:0065005)3.60611689
80amine catabolic process (GO:0009310)3.59874769
81cellular biogenic amine catabolic process (GO:0042402)3.59874769
82exogenous drug catabolic process (GO:0042738)3.58682521
83arginine metabolic process (GO:0006525)3.58318510
84lipoprotein metabolic process (GO:0042157)3.57730507
85indolalkylamine metabolic process (GO:0006586)3.55215978
86drug metabolic process (GO:0017144)3.53964474
87drug transmembrane transport (GO:0006855)3.52855886
88benzene-containing compound metabolic process (GO:0042537)3.52826401
89phospholipid homeostasis (GO:0055091)3.52332538
90regulation of cholesterol homeostasis (GO:2000188)3.50992541
91* modified amino acid transport (GO:0072337)3.47233440
92plasma lipoprotein particle organization (GO:0071827)3.46494558
93coenzyme catabolic process (GO:0009109)3.46388356
94urate metabolic process (GO:0046415)3.46161617
95purine ribonucleotide transport (GO:0015868)3.45044096
96organic acid catabolic process (GO:0016054)3.44511176
97carboxylic acid catabolic process (GO:0046395)3.44511176
98low-density lipoprotein particle remodeling (GO:0034374)3.38728484
99positive regulation of fatty acid biosynthetic process (GO:0045723)3.36992279
100nucleotide transmembrane transport (GO:1901679)3.34807182
101organic cation transport (GO:0015695)3.33849035
102blood coagulation, intrinsic pathway (GO:0007597)3.32981188
103fibrinolysis (GO:0042730)3.32913736
104dicarboxylic acid biosynthetic process (GO:0043650)3.31819193
105carnitine metabolic process (GO:0009437)3.28751877
106sulfur amino acid metabolic process (GO:0000096)3.28556416
107ethanol oxidation (GO:0006069)3.26849206
108positive regulation of lipid catabolic process (GO:0050996)3.25394074
109positive regulation of triglyceride metabolic process (GO:0090208)3.23982267
110protein-lipid complex subunit organization (GO:0071825)3.23698832
111negative regulation of lipase activity (GO:0060192)3.10387485
112ethanol metabolic process (GO:0006067)3.04179932
113phenylpropanoid metabolic process (GO:0009698)3.01524855
114purine nucleotide transport (GO:0015865)3.01353831
115cellular response to ATP (GO:0071318)2.95128573
116negative regulation of protein activation cascade (GO:2000258)2.93017088
117proline metabolic process (GO:0006560)2.91889187
118alkaloid metabolic process (GO:0009820)2.89814030
119behavioral response to nicotine (GO:0035095)2.89796425
120* heme transport (GO:0015886)2.88732145
121regulation of lipoprotein particle clearance (GO:0010984)2.88714443
122regulation of cholesterol biosynthetic process (GO:0045540)2.88289558
123peptidyl-glutamic acid modification (GO:0018200)2.86280322
124oxidative demethylation (GO:0070989)2.86035768
125primary alcohol catabolic process (GO:0034310)2.81457248
126aminoglycoside antibiotic metabolic process (GO:0030647)2.81143860
127S-adenosylmethionine metabolic process (GO:0046500)2.71778466
128regulation of cholesterol metabolic process (GO:0090181)2.71286602
129androgen biosynthetic process (GO:0006702)2.69448365
130adenine nucleotide transport (GO:0051503)2.68337389
131water-soluble vitamin biosynthetic process (GO:0042364)2.64887940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.02890537
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.28483581
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.39325789
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.30054714
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.58413540
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.54817951
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.45370988
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51846390
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.06837930
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70764201
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.66794481
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23105707
13P68_20966046_ChIP-Seq_HELA_Human2.05817651
14CTCF_27219007_Chip-Seq_Bcells_Human2.05023734
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0957005
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99043903
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97775206
18ZNF263_19887448_ChIP-Seq_K562_Human1.92711819
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87006355
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86881741
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84031086
22SMC4_20622854_ChIP-Seq_HELA_Human1.76672345
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72825191
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69434883
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65500310
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65476882
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61274858
28CLOCK_20551151_ChIP-Seq_293T_Human1.61151999
29DROSHA_22980978_ChIP-Seq_HELA_Human1.59526837
30E2F1_20622854_ChIP-Seq_HELA_Human1.55545344
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.54924938
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.51028591
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50773964
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49136942
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46338666
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46215831
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44415628
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44211494
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43962353
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40647222
41TP53_22127205_ChIP-Seq_IMR90_Human1.40267673
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40036176
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39737143
44STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.39394276
45NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.39316877
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.35222340
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34566225
48CTCF_20526341_ChIP-Seq_ESCs_Human1.34418787
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32181679
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31148955
51MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.30399208
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29366174
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29366174
54BCL6_27268052_Chip-Seq_Bcells_Human1.29055763
55ERA_21632823_ChIP-Seq_H3396_Human1.27585812
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26218629
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25502880
58CREB1_26743006_Chip-Seq_LNCaP_Human1.25131929
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25065536
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.22743680
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20672968
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.20148823
63* GATA4_25053715_ChIP-Seq_YYC3_Human1.19958013
64JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.18789429
65HTT_18923047_ChIP-ChIP_STHdh_Human1.18710495
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17990368
67OCT4_20526341_ChIP-Seq_ESCs_Human1.15900251
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.15011702
69VDR_21846776_ChIP-Seq_THP-1_Human1.14415249
70* TP63_22573176_ChIP-Seq_HFKS_Human1.14240007
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13823083
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13711277
73GATA1_22025678_ChIP-Seq_K562_Human1.13574361
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13208610
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12842658
76KDM2B_26808549_Chip-Seq_K562_Human1.12759823
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12538232
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12498831
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11269640
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10646341
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.10190004
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.08653561
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08580468
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08191723
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.07449724
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.07131163
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.06790087
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06726020
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06291560
90REST_21632747_ChIP-Seq_MESCs_Mouse1.06096458
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03893607
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03892950
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.02841222
94KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02314140
95RAC3_21632823_ChIP-Seq_H3396_Human1.02179130
96* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02120798
97FOXP1_21924763_ChIP-Seq_HESCs_Human1.00340205
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00002862
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98998380
100ETS1_20019798_ChIP-Seq_JURKAT_Human0.98934675
101SOX2_21211035_ChIP-Seq_LN229_Human0.98576889
102FOXA2_19822575_ChIP-Seq_HepG2_Human0.98552017
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.96978893
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96748873
105AR_21909140_ChIP-Seq_LNCAP_Human0.96364653
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95976810
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.95522709
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95507814
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94158756
110* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93799965
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93339869
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93102994
113RUNX1_27514584_Chip-Seq_MCF-7_Human0.92978934
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92464950
115* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91893666
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.91239013
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90778542
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88655993
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87247563
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86198900
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.84104757
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.81455017
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81001468
124YY1_21170310_ChIP-Seq_MESCs_Mouse0.80388670
125MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80258657
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.79837484
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79720693
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79192427
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.76374811
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75598259
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.73499240
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.71541131
133* TAF2_19829295_ChIP-Seq_ESCs_Human0.69333169
134NANOG_18692474_ChIP-Seq_MEFs_Mouse0.67870397
135GATA6_25053715_ChIP-Seq_YYC3_Human0.66469448
136RACK7_27058665_Chip-Seq_MCF-7_Human0.66461850
137NANOG_16518401_ChIP-PET_MESCs_Mouse0.65588489
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.64977977
139TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.64361828
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.63404009
141LXR_22292898_ChIP-Seq_THP-1_Human0.62773147
142POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.62736947
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61865456
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60997270
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60941419
146MYC_19915707_ChIP-ChIP_AK7_Human0.60674667
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59341578
148BCOR_27268052_Chip-Seq_Bcells_Human0.59182900
149ATF3_27146783_Chip-Seq_COLON_Human0.58692746
150TCF3_18692474_ChIP-Seq_MESCs_Mouse0.58662924
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.58301029
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58032532
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57324379
154SA1_27219007_Chip-Seq_Bcells_Human0.57257846
155SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.56087246
156POU5F1_16518401_ChIP-PET_MESCs_Mouse0.56084401
157PHF8_20622854_ChIP-Seq_HELA_Human0.55533601
158SOX2_20726797_ChIP-Seq_SW620_Human0.55505873
159KAP1_27257070_Chip-Seq_ESCs_Mouse0.55021087
160GATA3_21867929_ChIP-Seq_CD8_Mouse0.54269358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.00467139
2MP0002139_abnormal_hepatobiliary_system7.60385305
3MP0005085_abnormal_gallbladder_physiolo5.53259563
4MP0009840_abnormal_foam_cell5.25254769
5MP0005365_abnormal_bile_salt5.17462788
6MP0008875_abnormal_xenobiotic_pharmacok4.77588111
7MP0003806_abnormal_nucleotide_metabolis3.69483141
8MP0010329_abnormal_lipoprotein_level3.54706239
9MP0001666_abnormal_nutrient_absorption3.50906124
10MP0003252_abnormal_bile_duct3.43888390
11* MP0005332_abnormal_amino_acid3.00522783
12MP0004019_abnormal_vitamin_homeostasis2.91131727
13MP0000566_synostosis2.65257021
14MP0003195_calcinosis2.45492062
15MP0003191_abnormal_cellular_cholesterol2.18198645
16MP0005083_abnormal_biliary_tract2.11251899
17MP0002118_abnormal_lipid_homeostasis1.98001276
18MP0000609_abnormal_liver_physiology1.87828497
19MP0001764_abnormal_homeostasis1.87753932
20MP0005451_abnormal_body_composition1.74833803
21MP0005646_abnormal_pituitary_gland1.74674266
22MP0009697_abnormal_copulation1.74134397
23MP0005319_abnormal_enzyme/_coenzyme1.70483993
24MP0002909_abnormal_adrenal_gland1.69873483
25MP0003718_maternal_effect1.65467192
26MP0005423_abnormal_somatic_nervous1.64214122
27MP0004858_abnormal_nervous_system1.62028220
28MP0002160_abnormal_reproductive_system1.55699165
29MP0005551_abnormal_eye_electrophysiolog1.55616974
30MP0001986_abnormal_taste_sensitivity1.52628666
31MP0003122_maternal_imprinting1.48133745
32MP0009643_abnormal_urine_homeostasis1.45964381
33MP0004130_abnormal_muscle_cell1.37289236
34MP0005409_darkened_coat_color1.34491619
35MP0002254_reproductive_system_inflammat1.32026698
36MP0001968_abnormal_touch/_nociception1.30492947
37MP0001502_abnormal_circadian_rhythm1.30064884
38MP0005584_abnormal_enzyme/coenzyme_acti1.28239912
39MP0000013_abnormal_adipose_tissue1.27768510
40MP0003136_yellow_coat_color1.26773450
41MP0000604_amyloidosis1.26200294
42MP0003186_abnormal_redox_activity1.25259279
43MP0003868_abnormal_feces_composition1.24572060
44MP0003011_delayed_dark_adaptation1.22489166
45MP0005257_abnormal_intraocular_pressure1.20567135
46MP0005084_abnormal_gallbladder_morpholo1.18885526
47MP0005171_absent_coat_pigmentation1.18884197
48MP0005377_hearing/vestibular/ear_phenot1.18413471
49MP0003878_abnormal_ear_physiology1.18413471
50MP0003123_paternal_imprinting1.14710024
51MP0002822_catalepsy1.14247117
52MP0003329_amyloid_beta_deposits1.13740245
53MP0000003_abnormal_adipose_tissue1.12168965
54MP0001756_abnormal_urination1.09365024
55MP0003705_abnormal_hypodermis_morpholog1.06893870
56MP0002138_abnormal_hepatobiliary_system1.06823788
57MP0002736_abnormal_nociception_after1.05845854
58MP0002938_white_spotting1.04271394
59MP0002876_abnormal_thyroid_physiology1.03631320
60MP0005636_abnormal_mineral_homeostasis1.02770880
61MP0002249_abnormal_larynx_morphology1.01489312
62MP0004133_heterotaxia1.00990853
63MP0002638_abnormal_pupillary_reflex0.99470984
64MP0000534_abnormal_ureter_morphology0.98290439
65MP0000598_abnormal_liver_morphology0.95279423
66MP0001944_abnormal_pancreas_morphology0.94054234
67MP0009780_abnormal_chondrocyte_physiolo0.93297887
68MP0005376_homeostasis/metabolism_phenot0.90456111
69MP0006035_abnormal_mitochondrial_morpho0.89957981
70MP0005670_abnormal_white_adipose0.88953150
71MP0003315_abnormal_perineum_morphology0.87187463
72MP0005058_abnormal_lysosome_morphology0.86020516
73MP0009053_abnormal_anal_canal0.85873179
74MP0004043_abnormal_pH_regulation0.85649442
75MP0005266_abnormal_metabolism0.83116374
76MP0003656_abnormal_erythrocyte_physiolo0.82756621
77MP0005174_abnormal_tail_pigmentation0.82531720
78* MP0009642_abnormal_blood_homeostasis0.79652345
79MP0005395_other_phenotype0.79544148
80MP0003632_abnormal_nervous_system0.78420487
81MP0002653_abnormal_ependyma_morphology0.76969851
82MP0008260_abnormal_autophagy0.74394465
83MP0001919_abnormal_reproductive_system0.73492003
84MP0003942_abnormal_urinary_system0.73323569
85MP0000538_abnormal_urinary_bladder0.72335732
86MP0003690_abnormal_glial_cell0.71208655
87MP0005647_abnormal_sex_gland0.71172923
88MP0005076_abnormal_cell_differentiation0.71046650
89MP0004264_abnormal_extraembryonic_tissu0.70146593
90MP0006036_abnormal_mitochondrial_physio0.70112971
91MP0005410_abnormal_fertilization0.69607772
92MP0005448_abnormal_energy_balance0.68556006
93MP0000778_abnormal_nervous_system0.68329347
94MP0005167_abnormal_blood-brain_barrier0.66668376
95MP0003283_abnormal_digestive_organ0.65900916
96MP0002136_abnormal_kidney_physiology0.65470073
97MP0009384_cardiac_valve_regurgitation0.64932008
98MP0002557_abnormal_social/conspecific_i0.64375934
99MP0010030_abnormal_orbit_morphology0.63834985
100MP0001348_abnormal_lacrimal_gland0.62317274
101MP0002064_seizures0.62231617
102MP0002098_abnormal_vibrissa_morphology0.61986173
103MP0005389_reproductive_system_phenotype0.61583350
104MP0001324_abnormal_eye_pigmentation0.61412616
105MP0003693_abnormal_embryo_hatching0.60626328
106MP0000462_abnormal_digestive_system0.60075441
107MP0001661_extended_life_span0.59948933
108MP0003137_abnormal_impulse_conducting0.59822618
109MP0008872_abnormal_physiological_respon0.59797134
110MP0001270_distended_abdomen0.59628394
111MP0002796_impaired_skin_barrier0.59605388
112MP0002078_abnormal_glucose_homeostasis0.58929182
113MP0001188_hyperpigmentation0.58583375
114MP0008469_abnormal_protein_level0.56650919
115MP0009764_decreased_sensitivity_to0.54472113
116MP0009765_abnormal_xenobiotic_induced0.54439134
117MP0005535_abnormal_body_temperature0.53633508
118MP0003638_abnormal_response/metabolism_0.52494661
119MP0005408_hypopigmentation0.51828533
120MP0003183_abnormal_peptide_metabolism0.50980824
121MP0005334_abnormal_fat_pad0.50833675
122MP0009763_increased_sensitivity_to0.50338294
123MP0002090_abnormal_vision0.50247137
124MP0003953_abnormal_hormone_level0.49005906
125MP0005248_abnormal_Harderian_gland0.48238871
126MP0005220_abnormal_exocrine_pancreas0.45824233
127MP0001542_abnormal_bone_strength0.45717351
128MP0002971_abnormal_brown_adipose0.45562456
129MP0000230_abnormal_systemic_arterial0.44296948
130MP0003879_abnormal_hair_cell0.44237629
131MP0009672_abnormal_birth_weight0.41742694
132MP0004782_abnormal_surfactant_physiolog0.41633685
133MP0004885_abnormal_endolymph0.40047948
134MP0010234_abnormal_vibrissa_follicle0.34855840
135MP0001881_abnormal_mammary_gland0.34758388
136MP0002089_abnormal_postnatal_growth/wei0.34698399
137MP0008873_increased_physiological_sensi0.34622908
138MP0004883_abnormal_blood_vessel0.34447534
139MP0001765_abnormal_ion_homeostasis0.34394154
140MP0000647_abnormal_sebaceous_gland0.32446371
141MP0005166_decreased_susceptibility_to0.32279504
142MP0001440_abnormal_grooming_behavior0.30643598
143MP0005595_abnormal_vascular_smooth0.30338226
144MP0000358_abnormal_cell_content/0.27025829
145MP0000639_abnormal_adrenal_gland0.26243823
146MP0002069_abnormal_eating/drinking_beha0.25885424
147MP0002135_abnormal_kidney_morphology0.25503738
148MP0009115_abnormal_fat_cell0.25453195

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.60253256
2Xanthomatosis (HP:0000991)5.91985119
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.80830915
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.76696478
5Intrahepatic cholestasis (HP:0001406)5.67814121
6Hyperglycinuria (HP:0003108)5.57943211
7Hyperlipoproteinemia (HP:0010980)5.18546230
8Hyperglycinemia (HP:0002154)5.16393144
9Hypolipoproteinemia (HP:0010981)5.06858069
10Abnormality of glycine metabolism (HP:0010895)5.02387849
11Abnormality of serine family amino acid metabolism (HP:0010894)5.02387849
12Deep venous thrombosis (HP:0002625)4.98053898
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.95207507
14Prolonged partial thromboplastin time (HP:0003645)4.56154244
15Hyperammonemia (HP:0001987)4.47180116
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33643483
17Hypoalphalipoproteinemia (HP:0003233)4.20921627
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.14950465
19Complement deficiency (HP:0004431)4.14316533
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.89595944
21Fat malabsorption (HP:0002630)3.87868256
22Conjugated hyperbilirubinemia (HP:0002908)3.61049524
23Gout (HP:0001997)3.56647011
24Ketosis (HP:0001946)3.46337477
25Hemorrhage of the eye (HP:0011885)3.41782876
26Abnormality of serum amino acid levels (HP:0003112)3.37303643
27Abnormality of pyrimidine metabolism (HP:0004353)3.35542272
28Abnormality of methionine metabolism (HP:0010901)3.33915751
29Epidermoid cyst (HP:0200040)3.31692454
30Abnormality of fatty-acid metabolism (HP:0004359)3.28081166
31Hypercholesterolemia (HP:0003124)3.17029140
32Abnormality of nucleobase metabolism (HP:0010932)3.13808388
33Lethargy (HP:0001254)3.13656306
34Hypoglycemic coma (HP:0001325)3.09266638
35Abnormality of purine metabolism (HP:0004352)3.02941446
36Abnormality of the common coagulation pathway (HP:0010990)3.01953615
37Malnutrition (HP:0004395)3.01636017
38Abnormality of alanine metabolism (HP:0010916)2.99582655
39Hyperalaninemia (HP:0003348)2.99582655
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99582655
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98268993
42Turricephaly (HP:0000262)2.93249819
43Systemic lupus erythematosus (HP:0002725)2.90462390
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89808596
45Dicarboxylic aciduria (HP:0003215)2.89808596
46Ileus (HP:0002595)2.89635901
47Delayed CNS myelination (HP:0002188)2.89118245
48Joint hemorrhage (HP:0005261)2.88881172
49Abnormality of complement system (HP:0005339)2.88355537
50Chronic hepatic failure (HP:0100626)2.88025568
51Abnormality of proline metabolism (HP:0010907)2.87029496
52Hydroxyprolinuria (HP:0003080)2.87029496
53Metabolic acidosis (HP:0001942)2.86242276
54Ulnar bowing (HP:0003031)2.83507026
55Hypophosphatemic rickets (HP:0004912)2.77967906
56Rib fusion (HP:0000902)2.75318931
57Abnormality of the intrinsic pathway (HP:0010989)2.69897210
58Testicular atrophy (HP:0000029)2.69521949
59Acanthocytosis (HP:0001927)2.64591597
60Steatorrhea (HP:0002570)2.61598330
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59799627
62Glycosuria (HP:0003076)2.59308699
63Abnormality of urine glucose concentration (HP:0011016)2.59308699
64Hyperbilirubinemia (HP:0002904)2.53750810
65Ketoacidosis (HP:0001993)2.53690952
66Vaginal fistula (HP:0004320)2.51287293
67Mesangial abnormality (HP:0001966)2.48759487
68Attenuation of retinal blood vessels (HP:0007843)2.48082970
69Chorioretinal atrophy (HP:0000533)2.46970106
70Proximal tubulopathy (HP:0000114)2.46327837
71* Irritability (HP:0000737)2.45752611
72Increased purine levels (HP:0004368)2.44714501
73Hyperuricemia (HP:0002149)2.44714501
74Spastic paraparesis (HP:0002313)2.36788285
75Akinesia (HP:0002304)2.35496309
76Glomerulonephritis (HP:0000099)2.34306615
77Skin nodule (HP:0200036)2.33723752
78Vascular calcification (HP:0004934)2.33345502
79Sensorimotor neuropathy (HP:0007141)2.32014502
80Abnormal urine phosphate concentration (HP:0012599)2.31319944
81Vomiting (HP:0002013)2.28449549
82Brushfield spots (HP:0001088)2.27830136
83Generalized aminoaciduria (HP:0002909)2.26742079
84Congenital stationary night blindness (HP:0007642)2.26409220
85Nephritis (HP:0000123)2.22269112
86Nausea (HP:0002018)2.21843168
87Cerebral edema (HP:0002181)2.21396261
88Myocardial infarction (HP:0001658)2.17372029
89Prolonged neonatal jaundice (HP:0006579)2.15888161
90Hyperphosphaturia (HP:0003109)2.15828975
91Confusion (HP:0001289)2.14083574
92Hepatocellular carcinoma (HP:0001402)2.14083145
93Widely patent fontanelles and sutures (HP:0004492)2.13342614
94Mitral stenosis (HP:0001718)2.12162241
95Abnormal tarsal ossification (HP:0008369)2.07076273
96Opisthotonus (HP:0002179)2.06859291
97Abnormality of vitamin metabolism (HP:0100508)2.03770748
98Retinal atrophy (HP:0001105)2.03374247
99Cardiovascular calcification (HP:0011915)2.01265887
100Bony spicule pigmentary retinopathy (HP:0007737)2.00121261
101Birth length less than 3rd percentile (HP:0003561)1.99916051
102Cholecystitis (HP:0001082)1.97766627
103Abnormal gallbladder physiology (HP:0012438)1.97766627
104CNS demyelination (HP:0007305)1.97475975
105Spontaneous abortion (HP:0005268)1.96975821
106Pancreatitis (HP:0001733)1.95436757
107Abnormal cartilage morphology (HP:0002763)1.94509698
108Methylmalonic aciduria (HP:0012120)1.94000494
109Esophageal varix (HP:0002040)1.90692491
110Hyperglycemia (HP:0003074)1.89861304
111Late onset (HP:0003584)1.89624135
112Nephrolithiasis (HP:0000787)1.89002065
113Facial hemangioma (HP:0000329)1.88680920
114Amyloidosis (HP:0011034)1.88284885
115Poikilocytosis (HP:0004447)1.87476089
116Breast hypoplasia (HP:0003187)1.86683802
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86009324
118Abnormality of polysaccharide metabolism (HP:0011012)1.86009324
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86009324
120Spastic diplegia (HP:0001264)1.85192651
121Thin bony cortex (HP:0002753)1.85163068
122Paraparesis (HP:0002385)1.84365137
123Potter facies (HP:0002009)1.84084203
124Facial shape deformation (HP:0011334)1.84084203
125Rectal fistula (HP:0100590)1.83743838
126Rectovaginal fistula (HP:0000143)1.83743838
127Neonatal onset (HP:0003623)1.83215051
128Rickets (HP:0002748)1.81370846
129Mucopolysacchariduria (HP:0008155)1.80625660
130Urinary glycosaminoglycan excretion (HP:0003541)1.80625660
131Hyperinsulinemic hypoglycemia (HP:0000825)1.80278121
132Bowing of the arm (HP:0006488)1.76664736
133Bowed forearm bones (HP:0003956)1.76664736
134Abnormal enzyme/coenzyme activity (HP:0012379)1.75725467
135Abnormal glucose tolerance (HP:0001952)1.73914100
136Protuberant abdomen (HP:0001538)1.73424556
137* Megaloblastic anemia (HP:0001889)1.73237359
138Abnormal gallbladder morphology (HP:0012437)1.72993645
139Abnormality of transition element cation homeostasis (HP:0011030)1.72831793
140Status epilepticus (HP:0002133)1.72133111
141Choanal stenosis (HP:0000452)1.71417575
142Abnormal drinking behavior (HP:0030082)1.69712106
143Polydipsia (HP:0001959)1.69712106
144Congenital sensorineural hearing impairment (HP:0008527)1.68421528
145Pigmentary retinal degeneration (HP:0001146)1.65428977
146Decreased central vision (HP:0007663)1.65196298
147Intestinal fistula (HP:0100819)1.64831220
148Abnormal urine output (HP:0012590)1.63599269
149Hypophosphatemia (HP:0002148)1.63224682
150Coronal craniosynostosis (HP:0004440)1.62990087
151Choroideremia (HP:0001139)1.61314699
152Reduced antithrombin III activity (HP:0001976)1.61261203
153Bifid scrotum (HP:0000048)1.61079304
154Aplasia of the musculature (HP:0100854)1.59671043
155Poikiloderma (HP:0001029)1.56210346
156Decreased circulating renin level (HP:0003351)1.56120050
157Abnormality of the vitreous humor (HP:0004327)1.55002555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.32720834
2BCKDK5.24757200
3WNK44.15877833
4AKT33.52891806
5BUB13.22859421
6PRKD32.67444761
7STK162.62214286
8FRK2.52566872
9ERN12.44068247
10TLK12.31698594
11NTRK32.30805586
12WEE12.25329509
13MST1R2.25105200
14FGFR42.21821075
15NME12.17527781
16IRAK32.13717989
17CAMK1G2.11748311
18TSSK62.10125016
19PDK22.06137036
20PNCK1.97595349
21PDK31.90666169
22PDK41.90666169
23ICK1.90653808
24PINK11.90553493
25STK38L1.87125822
26CAMKK21.72445298
27SIK11.64132880
28MAP2K21.63765770
29MAP2K41.60539990
30ERBB41.57411908
31FGFR21.54211962
32NEK11.53848358
33GRK61.53492360
34EPHB11.48426508
35ARAF1.39474448
36STK391.34613561
37NTRK21.28646637
38ACVR1B1.18824048
39PRKD21.15537871
40MARK11.14626179
41EIF2AK11.13886088
42ABL21.08585951
43CDK191.08553180
44INSRR1.04583611
45DYRK1B1.03836421
46MAP2K61.01700177
47CAMKK11.01648292
48CASK0.99733045
49PRKCI0.97483599
50WNK10.97329964
51TTK0.95892577
52PHKG10.95718820
53PHKG20.95718820
54BRAF0.95642947
55PLK40.93245865
56TAOK20.92903263
57TESK20.90889744
58PRKCG0.90820324
59RPS6KA20.88895726
60TNK20.88009668
61MAP2K10.86741171
62CAMK2G0.86034223
63MTOR0.85545688
64LATS20.85009706
65GRK10.84164653
66LMTK20.82587682
67MAP3K30.81694968
68MAPK110.79570966
69FER0.74237544
70PIM20.73692148
71NEK60.73603252
72PIK3CA0.73396565
73PLK30.72256487
74MAPK120.71947874
75PRKAA10.71203185
76AURKA0.71099608
77EPHA40.70542855
78MUSK0.70226562
79PRKCZ0.70101876
80EPHB20.69965711
81SIK20.68584566
82ERBB20.67375535
83MAP3K90.67290555
84EEF2K0.65962168
85MAPK130.65351720
86MAP3K20.64914067
87ADRBK20.63582439
88PTK20.62286978
89MET0.62087586
90STK380.61640908
91SMG10.61009985
92STK110.59389641
93PRKAA20.59209457
94WNK30.58948058
95LATS10.58240662
96RPS6KA60.57339707
97TRIB30.55776564
98ADRBK10.55710239
99RPS6KB10.54530019
100ZAK0.53284984
101CDK50.52387321
102AKT20.51794056
103NME20.50962218
104CAMK40.50226663
105PRKACG0.49679319
106PKN20.49547516
107CSNK1G10.49471346
108HIPK20.49306832
109DAPK20.48861790
110MAPK40.48581615
111PRKACA0.48395038
112TYRO30.47817042
113NUAK10.46087399
114EIF2AK30.45968916
115CAMK10.45958365
116MAP3K110.45308420
117CSNK1E0.44868039
118CSNK1G20.42262567
119CSNK1D0.42072928
120PRKD10.42033428
121PAK40.41414991
122PRKG20.40718359
123SGK10.40640398
124CDK120.40308827
125DYRK30.40269338
126CSNK1G30.40225141
127TYK20.40184333
128MAPK150.39798460
129FGFR30.39479254
130SGK4940.38893031
131SGK2230.38893031
132CSNK1A10.38793578
133PDPK10.38621426
134CDK40.38243306
135PTK60.38086464
136PDK10.37808484
137NEK90.37777792
138SGK30.37639502
139SGK20.37119076
140PRKCA0.34568160
141TAOK30.33415788
142KDR0.32447657
143PAK30.31570492
144GSK3A0.31570272
145CAMK1D0.31358130
146BRSK10.29402062
147CSNK2A10.29219602
148MAP2K30.29128870
149CAMK2B0.28631081
150DYRK20.28592096

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.46338184
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06211644
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71624641
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.64869365
5Arginine biosynthesis_Homo sapiens_hsa002202.62923179
6Nitrogen metabolism_Homo sapiens_hsa009102.58645023
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51879976
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34926676
9Fat digestion and absorption_Homo sapiens_hsa049752.31809068
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.27473004
11Tryptophan metabolism_Homo sapiens_hsa003802.25844878
12Fatty acid degradation_Homo sapiens_hsa000712.17908682
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.11259309
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08843506
15Folate biosynthesis_Homo sapiens_hsa007902.04213982
16Butanoate metabolism_Homo sapiens_hsa006502.02232502
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92980225
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.90942243
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89260714
20Complement and coagulation cascades_Homo sapiens_hsa046101.89221798
21Caffeine metabolism_Homo sapiens_hsa002321.89147905
22Vitamin B6 metabolism_Homo sapiens_hsa007501.87357561
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86666879
24Peroxisome_Homo sapiens_hsa041461.84142504
25* Vitamin digestion and absorption_Homo sapiens_hsa049771.79745555
26Histidine metabolism_Homo sapiens_hsa003401.77436709
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76202746
28PPAR signaling pathway_Homo sapiens_hsa033201.74056143
29Chemical carcinogenesis_Homo sapiens_hsa052041.70178469
30beta-Alanine metabolism_Homo sapiens_hsa004101.68807996
31Fatty acid metabolism_Homo sapiens_hsa012121.63582024
32Starch and sucrose metabolism_Homo sapiens_hsa005001.63141557
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.60922146
34Retinol metabolism_Homo sapiens_hsa008301.59408894
35Propanoate metabolism_Homo sapiens_hsa006401.58670020
36Bile secretion_Homo sapiens_hsa049761.52517529
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48568859
38Sulfur metabolism_Homo sapiens_hsa009201.48500025
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.46213969
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45176061
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.43129427
42Selenocompound metabolism_Homo sapiens_hsa004501.37743216
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36987515
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36202486
45Carbon metabolism_Homo sapiens_hsa012001.34411811
46Biosynthesis of amino acids_Homo sapiens_hsa012301.33805350
47Pyruvate metabolism_Homo sapiens_hsa006201.31967063
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31188741
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29853842
50Phenylalanine metabolism_Homo sapiens_hsa003601.23785421
51Arginine and proline metabolism_Homo sapiens_hsa003301.22342914
52Steroid biosynthesis_Homo sapiens_hsa001001.18594029
53Fructose and mannose metabolism_Homo sapiens_hsa000511.18155866
54Galactose metabolism_Homo sapiens_hsa000521.15799456
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15760813
56Glutathione metabolism_Homo sapiens_hsa004801.13867580
57Sulfur relay system_Homo sapiens_hsa041221.12069133
58Tyrosine metabolism_Homo sapiens_hsa003501.09078258
59Fatty acid elongation_Homo sapiens_hsa000621.08610601
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04745011
61Renin-angiotensin system_Homo sapiens_hsa046141.03050276
62Staphylococcus aureus infection_Homo sapiens_hsa051501.02101744
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.01550846
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01407017
65Glycerolipid metabolism_Homo sapiens_hsa005610.99857667
66ABC transporters_Homo sapiens_hsa020100.96455463
67Pentose phosphate pathway_Homo sapiens_hsa000300.96080893
68Ether lipid metabolism_Homo sapiens_hsa005650.85768570
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85688288
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84233823
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79118739
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.75769779
73* Mineral absorption_Homo sapiens_hsa049780.75145888
74Regulation of autophagy_Homo sapiens_hsa041400.72123365
75Proteasome_Homo sapiens_hsa030500.71981208
76Metabolic pathways_Homo sapiens_hsa011000.71021941
77Ovarian steroidogenesis_Homo sapiens_hsa049130.67345194
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66920191
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61038480
80One carbon pool by folate_Homo sapiens_hsa006700.59148085
81Nicotine addiction_Homo sapiens_hsa050330.58645217
82Fatty acid biosynthesis_Homo sapiens_hsa000610.51696626
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41784126
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40609163
85Lysine degradation_Homo sapiens_hsa003100.39215848
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39058250
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35282906
88Linoleic acid metabolism_Homo sapiens_hsa005910.32751065
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32602237
90GABAergic synapse_Homo sapiens_hsa047270.30697866
91N-Glycan biosynthesis_Homo sapiens_hsa005100.30284661
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27058551
93Arachidonic acid metabolism_Homo sapiens_hsa005900.26925209
94Phototransduction_Homo sapiens_hsa047440.26414744
95Prion diseases_Homo sapiens_hsa050200.25942936
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25702790
97Insulin secretion_Homo sapiens_hsa049110.24922463
98Protein digestion and absorption_Homo sapiens_hsa049740.22989981
99Taste transduction_Homo sapiens_hsa047420.22234741
100Glutamatergic synapse_Homo sapiens_hsa047240.21750566
101Serotonergic synapse_Homo sapiens_hsa047260.21700473
102Synaptic vesicle cycle_Homo sapiens_hsa047210.21210676
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21109087
104Pyrimidine metabolism_Homo sapiens_hsa002400.20741495
105Sphingolipid metabolism_Homo sapiens_hsa006000.13261739
106Oxidative phosphorylation_Homo sapiens_hsa001900.12571537
107RNA polymerase_Homo sapiens_hsa030200.11369328
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.10702497
109Lysosome_Homo sapiens_hsa041420.10379789
110Purine metabolism_Homo sapiens_hsa002300.05721086
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05374932
112Circadian rhythm_Homo sapiens_hsa047100.04487047
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0623590
114Parkinsons disease_Homo sapiens_hsa05012-0.0508549
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0498308
116AMPK signaling pathway_Homo sapiens_hsa04152-0.0448766
117Other glycan degradation_Homo sapiens_hsa00511-0.0427871
118Collecting duct acid secretion_Homo sapiens_hsa04966-0.0091203
119Insulin resistance_Homo sapiens_hsa04931-0.0028143
120Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0024172

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