SLC45A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.06062321
2positive regulation by symbiont of host defense response (GO:0052509)6.03220249
3modulation by symbiont of host defense response (GO:0052031)6.03220249
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.03220249
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.03220249
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.03220249
7modulation by symbiont of host immune response (GO:0052553)6.03220249
8negative regulation of cell killing (GO:0031342)5.80201096
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.80201096
10positive regulation of gamma-delta T cell activation (GO:0046645)5.09989067
11macrophage activation involved in immune response (GO:0002281)5.07366784
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.99582739
13detection of molecule of bacterial origin (GO:0032490)4.92703328
14detection of other organism (GO:0098543)4.82817412
15positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.76324787
16neutrophil activation involved in immune response (GO:0002283)4.74424749
17antigen processing and presentation of endogenous antigen (GO:0019883)4.65034754
18gonadal mesoderm development (GO:0007506)4.64988870
19response to peptidoglycan (GO:0032494)4.55714316
20detection of external biotic stimulus (GO:0098581)4.47588901
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46644046
22detection of bacterium (GO:0016045)4.44459534
23cellular extravasation (GO:0045123)4.26777704
24regulation of interferon-beta biosynthetic process (GO:0045357)4.25915976
25regulation of B cell receptor signaling pathway (GO:0050855)4.25261201
26pre-miRNA processing (GO:0031054)4.11770929
27regulation of translational termination (GO:0006449)4.05208206
28neutrophil activation (GO:0042119)4.01389228
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.00724912
30response to host immune response (GO:0052572)3.99647578
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.99647578
32negative regulation of interleukin-12 production (GO:0032695)3.91406900
33regulation of gamma-delta T cell activation (GO:0046643)3.89915619
34macrophage activation (GO:0042116)3.88629244
35detection of biotic stimulus (GO:0009595)3.87153865
36respiratory burst (GO:0045730)3.84655456
37microglial cell activation (GO:0001774)3.81750835
38leukocyte migration involved in inflammatory response (GO:0002523)3.81750257
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81732634
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.77464981
41response to host (GO:0075136)3.77464981
42response to host defenses (GO:0052200)3.77464981
43leukocyte aggregation (GO:0070486)3.76857383
44layer formation in cerebral cortex (GO:0021819)3.76833769
45response to interleukin-15 (GO:0070672)3.75865375
46histone H4-K12 acetylation (GO:0043983)3.75364771
47heterochromatin organization (GO:0070828)3.73500903
48synaptonemal complex assembly (GO:0007130)3.69648150
49negative regulation of erythrocyte differentiation (GO:0045647)3.67048345
50granulocyte activation (GO:0036230)3.66918083
51positive regulation of fibroblast migration (GO:0010763)3.64240721
52peptidyl-lysine dimethylation (GO:0018027)3.62549780
53negative regulation of leukocyte mediated immunity (GO:0002704)3.62103830
54regulation of meiosis I (GO:0060631)3.61845774
55regulation of mast cell degranulation (GO:0043304)3.61515675
56sodium ion export (GO:0071436)3.61267472
57mitotic G1 DNA damage checkpoint (GO:0031571)3.61126982
58regulation of gamma-delta T cell differentiation (GO:0045586)3.58351960
59neutrophil mediated immunity (GO:0002446)3.57765286
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.57201479
61myeloid cell activation involved in immune response (GO:0002275)3.50094597
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.45540710
63regulation of leukocyte degranulation (GO:0043300)3.44496508
64regulation of short-term neuronal synaptic plasticity (GO:0048172)3.43944986
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.42966794
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41804007
67production of molecular mediator involved in inflammatory response (GO:0002532)3.41727954
68cellular response to interleukin-15 (GO:0071350)3.39453534
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.38648952
70synaptonemal complex organization (GO:0070193)3.35270033
71histone H4-K5 acetylation (GO:0043981)3.34989168
72histone H4-K8 acetylation (GO:0043982)3.34989168
73germinal center formation (GO:0002467)3.32039072
74regulation of T-helper 2 cell differentiation (GO:0045628)3.31245268
75negative regulation of cell size (GO:0045792)3.30574351
76synaptic vesicle maturation (GO:0016188)3.30427843
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.28629325
78regulation of mast cell activation involved in immune response (GO:0033006)3.28541524
79response to muramyl dipeptide (GO:0032495)3.26154800
80negative regulation of toll-like receptor signaling pathway (GO:0034122)3.23848185
81regulation of regulated secretory pathway (GO:1903305)3.18274065
82locomotory exploration behavior (GO:0035641)3.16880331
83G1 DNA damage checkpoint (GO:0044783)3.14532943
84negative regulation of microtubule polymerization (GO:0031115)3.14449694
85regulation of tolerance induction (GO:0002643)3.11101512
86sex determination (GO:0007530)3.10975718
87regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.10178986
88immunoglobulin mediated immune response (GO:0016064)3.08877760
89B cell receptor signaling pathway (GO:0050853)3.08669511
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07699773
91cell migration in hindbrain (GO:0021535)3.07226910
92adherens junction assembly (GO:0034333)3.05980142
93negative regulation of T cell mediated immunity (GO:0002710)3.05193339
94lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04889914
95cell communication by electrical coupling (GO:0010644)3.02208245
96NLS-bearing protein import into nucleus (GO:0006607)3.02205138
97positive regulation of mast cell activation (GO:0033005)3.02097564
98myeloid leukocyte mediated immunity (GO:0002444)3.01328619
99antigen processing and presentation via MHC class Ib (GO:0002475)2.99263561
100cell-substrate adherens junction assembly (GO:0007045)2.98858919
101focal adhesion assembly (GO:0048041)2.98858919
102piRNA metabolic process (GO:0034587)2.98011806
103regulation of clathrin-mediated endocytosis (GO:2000369)2.97926906
104response to type I interferon (GO:0034340)2.97022229
105tolerance induction (GO:0002507)2.96980977
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96573466
107type I interferon signaling pathway (GO:0060337)2.96284288
108cellular response to type I interferon (GO:0071357)2.96284288
109sex differentiation (GO:0007548)2.94193212
110activation of protein kinase A activity (GO:0034199)2.93436491
111leukocyte degranulation (GO:0043299)2.90349828
112positive regulation of Cdc42 GTPase activity (GO:0043089)2.90327762
113peptidyl-arginine omega-N-methylation (GO:0035247)2.90103479
114regulation of translational fidelity (GO:0006450)2.89849793
115positive regulation of cellular amide metabolic process (GO:0034250)2.89537772
116negative regulation of type 2 immune response (GO:0002829)2.88010124
117gene silencing by RNA (GO:0031047)2.87359806
118glucocorticoid receptor signaling pathway (GO:0042921)2.86551032
119mitotic G1/S transition checkpoint (GO:0044819)2.86385586
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.85869015
121plasma membrane repair (GO:0001778)2.85442174
122negative regulation of organelle assembly (GO:1902116)2.84914592
123cellular potassium ion homeostasis (GO:0030007)2.84099119
124DNA unwinding involved in DNA replication (GO:0006268)2.83446523
125regulation of mast cell activation (GO:0033003)2.83032423
126negative regulation of interleukin-6 production (GO:0032715)2.82087774
127regulation of T cell tolerance induction (GO:0002664)2.81759208
128neuromuscular process controlling posture (GO:0050884)2.80702188
129establishment of apical/basal cell polarity (GO:0035089)2.80140486
130positive regulation of SMAD protein import into nucleus (GO:0060391)2.79620150
131regulation of NFAT protein import into nucleus (GO:0051532)2.79051561
132positive regulation of synapse maturation (GO:0090129)2.77583794
133regulation of toll-like receptor signaling pathway (GO:0034121)2.77343296
134proline transport (GO:0015824)2.74844252
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74212908
136dendritic cell chemotaxis (GO:0002407)2.73699028
137dendritic cell migration (GO:0036336)2.72534045
138positive regulation of interferon-alpha production (GO:0032727)2.72214760
139regulation of necroptotic process (GO:0060544)2.72090951
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71559999
141negative regulation of histone methylation (GO:0031061)2.70703131
142histone H4-K16 acetylation (GO:0043984)2.69316357
143myeloid leukocyte activation (GO:0002274)2.68962131
144positive regulation of regulated secretory pathway (GO:1903307)2.68822568
145negative regulation of T-helper cell differentiation (GO:0045623)2.68812223
146negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68812223
147oocyte development (GO:0048599)2.67991291
148neutrophil chemotaxis (GO:0030593)2.66752762
149regulation of B cell differentiation (GO:0045577)2.65930731
150defense response to protozoan (GO:0042832)2.65424004
151regulation of early endosome to late endosome transport (GO:2000641)2.65330148
152positive regulation of mast cell activation involved in immune response (GO:0033008)2.65133676
153positive regulation of mast cell degranulation (GO:0043306)2.65133676
154synaptic vesicle docking involved in exocytosis (GO:0016081)2.64991569
155glial cell proliferation (GO:0014009)2.64651560
156positive regulation of tolerance induction (GO:0002645)2.63043086
157negative regulation of B cell mediated immunity (GO:0002713)2.63014033
158CDP-diacylglycerol metabolic process (GO:0046341)2.62460434
159glutamate secretion (GO:0014047)2.62150360
160peptidyl-arginine methylation (GO:0018216)2.61054512
161peptidyl-arginine N-methylation (GO:0035246)2.61054512
162anatomical structure regression (GO:0060033)2.60316368
163mannose metabolic process (GO:0006013)2.59671951
164positive regulation of male gonad development (GO:2000020)2.59577596
165trophectodermal cell differentiation (GO:0001829)2.56620528
166establishment of nucleus localization (GO:0040023)2.56565745
167establishment or maintenance of monopolar cell polarity (GO:0061339)2.56357111
168establishment of monopolar cell polarity (GO:0061162)2.56357111
169regulation of ARF GTPase activity (GO:0032312)2.54323839
170gene silencing (GO:0016458)2.54051066
171regulation of posttranscriptional gene silencing (GO:0060147)2.53946639
172regulation of gene silencing by miRNA (GO:0060964)2.53946639
173regulation of gene silencing by RNA (GO:0060966)2.53946639
174neuromuscular process controlling balance (GO:0050885)2.52683631
175nuclear pore organization (GO:0006999)2.52416634
176protein localization to kinetochore (GO:0034501)2.52202789
177regulation of hippo signaling (GO:0035330)2.50896575
178nuclear pore complex assembly (GO:0051292)2.50585396
179DNA methylation involved in gamete generation (GO:0043046)2.49100781
180CDP-diacylglycerol biosynthetic process (GO:0016024)2.48621904
181chaperone-mediated protein complex assembly (GO:0051131)2.47382782
182translesion synthesis (GO:0019985)2.46885077
183labyrinthine layer blood vessel development (GO:0060716)2.44670455
184macroautophagy (GO:0016236)2.44046217
185cell-substrate junction assembly (GO:0007044)2.43529533
186growth hormone secretion (GO:0030252)2.43345387
187negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.43113222
188regulation of SMAD protein import into nucleus (GO:0060390)2.42649756
189negative regulation of meiosis (GO:0045835)2.41661948
190L-alpha-amino acid transmembrane transport (GO:1902475)2.41389953
191clathrin coat assembly (GO:0048268)2.41021893
192negative regulation of potassium ion transmembrane transport (GO:1901380)2.39485964
193male sex determination (GO:0030238)2.38933473
194regulation of histone H3-K9 methylation (GO:0051570)2.38577486
195histone H2A monoubiquitination (GO:0035518)2.37302447
196histone arginine methylation (GO:0034969)2.37244290
197stress fiber assembly (GO:0043149)2.37236610
198fibroblast migration (GO:0010761)2.35441001
199cell-cell junction maintenance (GO:0045217)2.34684930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.98931638
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.89638402
3E2F7_22180533_ChIP-Seq_HELA_Human3.84893625
4ZNF263_19887448_ChIP-Seq_K562_Human3.82906534
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.46947512
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02867835
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96274424
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.93066337
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.93051117
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.84574918
11MYC_22102868_ChIP-Seq_BL_Human2.70322034
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67745993
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.55651489
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.54507711
15SPI1_23127762_ChIP-Seq_K562_Human2.54454476
16* VDR_24763502_ChIP-Seq_THP-1_Human2.50365458
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39462754
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39462754
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39462754
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38178792
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37305173
22* KDM2B_26808549_Chip-Seq_DND41_Human2.35277742
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31726333
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.29189244
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28379810
26SCL_19346495_ChIP-Seq_HPC-7_Human2.27679360
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25764573
28TCF7_22412390_ChIP-Seq_EML_Mouse2.17635918
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17170619
30MAF_26560356_Chip-Seq_TH1_Human2.14091503
31RUNX_20019798_ChIP-Seq_JUKART_Human2.09107198
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09076443
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06516325
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.06451839
35SPI1_23547873_ChIP-Seq_NB4_Human2.03077510
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02884264
37BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00375579
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98953650
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98075968
40* KDM2B_26808549_Chip-Seq_K562_Human1.97830975
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97780695
42* LXR_22292898_ChIP-Seq_THP-1_Human1.95674771
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95549777
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95031707
45UTX_26944678_Chip-Seq_JUKART_Human1.91094364
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88557145
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.87820050
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85159891
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81842456
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77237719
51VDR_21846776_ChIP-Seq_THP-1_Human1.74777246
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.73699008
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.71918425
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71086380
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70675921
56* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70166106
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67142075
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67004845
59* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66872706
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64870670
61RACK7_27058665_Chip-Seq_MCF-7_Human1.61001617
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60359003
63* RARB_27405468_Chip-Seq_BRAIN_Mouse1.59922355
64* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58285756
65MAF_26560356_Chip-Seq_TH2_Human1.57976294
66MYB_26560356_Chip-Seq_TH2_Human1.57613141
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57232519
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55796830
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54588063
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53284476
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51733361
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51301098
73GATA1_19941826_ChIP-Seq_K562_Human1.51027926
74CREB1_26743006_Chip-Seq_LNCaP_Human1.49949864
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.49887059
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.49028145
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48961031
78GATA1_22025678_ChIP-Seq_K562_Human1.48404447
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48044247
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47566616
81MYB_26560356_Chip-Seq_TH1_Human1.46296826
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45969743
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45839754
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44015738
85VDR_24787735_ChIP-Seq_THP-1_Human1.43004983
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42939269
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40759129
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.39958599
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39618626
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39387020
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38754796
92ATF3_27146783_Chip-Seq_COLON_Human1.37774243
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36834688
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32523399
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.31420438
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31050613
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29680336
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29473222
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28749404
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27946408
101P68_20966046_ChIP-Seq_HELA_Human1.27935398
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.26763424
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26278664
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26151788
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25567827
106* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24889564
107* GATA2_21666600_ChIP-Seq_HMVEC_Human1.24842764
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24185929
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23185522
110* SMC4_20622854_ChIP-Seq_HELA_Human1.23090842
111* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22933889
112GATA3_27048872_Chip-Seq_THYMUS_Human1.22816069
113* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22269333
114NCOR1_26117541_ChIP-Seq_K562_Human1.21803069
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19710562
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16061307
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15831337
118* RUNX1_27514584_Chip-Seq_MCF-7_Human1.15649067
119IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15526168
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14901178
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14073323
122* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13808585
123GATA2_19941826_ChIP-Seq_K562_Human1.13598274
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12951868
125SA1_27219007_Chip-Seq_ERYTHROID_Human1.12823870
126CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12511502
127TP53_22127205_ChIP-Seq_IMR90_Human1.12263930
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11978908
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11381082
130CIITA_25753668_ChIP-Seq_RAJI_Human1.10645497
131DROSHA_22980978_ChIP-Seq_HELA_Human1.10539949
132* OCT4_19829295_ChIP-Seq_ESCs_Human1.09584045
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08168259
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08147667
135PU_27001747_Chip-Seq_BMDM_Mouse1.07984536
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07823601
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07745691
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06407342
139* BCOR_27268052_Chip-Seq_Bcells_Human1.05508016
140PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05493384
141SMAD_19615063_ChIP-ChIP_OVARY_Human1.05350272
142PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04901608
143HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04707729
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04294891
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03653316
146* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02876409
147ELF1_20517297_ChIP-Seq_JURKAT_Human1.02292909
148CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01492385
149DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01155963
150* BCL6_27268052_Chip-Seq_Bcells_Human1.00742592
151FOXP1_21924763_ChIP-Seq_HESCs_Human1.00678664
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00341675
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99991235
154RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99958052
155POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99700827
156TET1_21490601_ChIP-Seq_MESCs_Mouse0.99278785
157* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99254556
158CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98483366
159* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97134473
160E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96497389
161FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96388262
162GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95391053
163PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95029456
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93778682
165CHD1_26751641_Chip-Seq_LNCaP_Human0.93563484
166SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92583162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.07345858
2MP0004859_abnormal_synaptic_plasticity4.46994917
3MP0003303_peritoneal_inflammation4.26775206
4MP0003436_decreased_susceptibility_to4.02805350
5MP0002419_abnormal_innate_immunity2.95079803
6MP0001835_abnormal_antigen_presentation2.87672847
7MP0004858_abnormal_nervous_system2.70712317
8MP0010352_gastrointestinal_tract_polyps2.69992831
9MP0009278_abnormal_bone_marrow2.69698474
10MP0008260_abnormal_autophagy2.67715426
11MP0008995_early_reproductive_senescence2.66632038
12MP0005025_abnormal_response_to2.63445413
13MP0005623_abnormal_meninges_morphology2.57319257
14MP0003191_abnormal_cellular_cholesterol2.53072920
15MP0002132_abnormal_respiratory_system2.44044539
16MP0001800_abnormal_humoral_immune2.37224164
17MP0005000_abnormal_immune_tolerance2.32695943
18MP0003705_abnormal_hypodermis_morpholog2.32672942
19MP0001790_abnormal_immune_system2.29819189
20MP0005387_immune_system_phenotype2.29819189
21MP0008877_abnormal_DNA_methylation2.29312482
22MP0000751_myopathy2.28922262
23MP0005451_abnormal_body_composition2.26788964
24MP0000685_abnormal_immune_system2.25756762
25MP0009785_altered_susceptibility_to2.25091565
26MP0006082_CNS_inflammation2.23239780
27MP0002723_abnormal_immune_serum2.22207434
28MP0002420_abnormal_adaptive_immunity2.22092441
29MP0001819_abnormal_immune_cell2.20562448
30MP0003123_paternal_imprinting2.19415934
31MP0005671_abnormal_response_to2.12888302
32MP0002452_abnormal_antigen_presenting2.12093058
33MP0003878_abnormal_ear_physiology2.11348070
34MP0005377_hearing/vestibular/ear_phenot2.11348070
35MP0001533_abnormal_skeleton_physiology2.00624039
36MP0010234_abnormal_vibrissa_follicle1.99673379
37MP0002653_abnormal_ependyma_morphology1.92468280
38MP0008961_abnormal_basal_metabolism1.91812177
39MP0004947_skin_inflammation1.89315960
40MP0003763_abnormal_thymus_physiology1.87920298
41MP0005464_abnormal_platelet_physiology1.86960523
42MP0004084_abnormal_cardiac_muscle1.86944034
43MP0002405_respiratory_system_inflammati1.84215912
44MP0003283_abnormal_digestive_organ1.84193143
45MP0000465_gastrointestinal_hemorrhage1.83902516
46MP0003635_abnormal_synaptic_transmissio1.83745298
47MP0004510_myositis1.79469190
48MP0002148_abnormal_hypersensitivity_rea1.79324508
49MP0010155_abnormal_intestine_physiology1.74798578
50MP0000569_abnormal_digit_pigmentation1.73303465
51MP0002398_abnormal_bone_marrow1.68683477
52MP0004233_abnormal_muscle_weight1.67609783
53MP0004381_abnormal_hair_follicle1.65513843
54MP0000716_abnormal_immune_system1.64403307
55MP0003183_abnormal_peptide_metabolism1.60407238
56MP0004957_abnormal_blastocyst_morpholog1.59284141
57MP0010307_abnormal_tumor_latency1.58867458
58MP0003879_abnormal_hair_cell1.58579146
59MP0005076_abnormal_cell_differentiation1.56229889
60MP0003045_fibrosis1.54983912
61MP0003866_abnormal_defecation1.54119022
62MP0002277_abnormal_respiratory_mucosa1.52547954
63MP0003111_abnormal_nucleus_morphology1.52103834
64MP0004145_abnormal_muscle_electrophysio1.50928818
65MP0004885_abnormal_endolymph1.48738181
66MP0001845_abnormal_inflammatory_respons1.48662151
67MP0005310_abnormal_salivary_gland1.46609541
68MP0000858_altered_metastatic_potential1.45350756
69MP0002909_abnormal_adrenal_gland1.42321099
70MP0000747_muscle_weakness1.41142814
71MP0003075_altered_response_to1.39686169
72MP0002722_abnormal_immune_system1.39617032
73MP0009333_abnormal_splenocyte_physiolog1.39141548
74MP0005397_hematopoietic_system_phenotyp1.38755479
75MP0001545_abnormal_hematopoietic_system1.38755479
76MP0001730_embryonic_growth_arrest1.36417461
77MP0005058_abnormal_lysosome_morphology1.35459093
78MP0004811_abnormal_neuron_physiology1.34763453
79MP0000703_abnormal_thymus_morphology1.33218852
80MP0004197_abnormal_fetal_growth/weight/1.32277124
81MP0004883_abnormal_blood_vessel1.31100064
82MP0004270_analgesia1.31081463
83MP0002429_abnormal_blood_cell1.30878017
84MP0002084_abnormal_developmental_patter1.29492759
85MP0003329_amyloid_beta_deposits1.27581694
86MP0005410_abnormal_fertilization1.27310371
87MP0000689_abnormal_spleen_morphology1.26303180
88MP0002998_abnormal_bone_remodeling1.24108653
89MP0001851_eye_inflammation1.23361622
90MP0001145_abnormal_male_reproductive1.23091769
91MP0002269_muscular_atrophy1.22910310
92MP0003566_abnormal_cell_adhesion1.21837363
93MP0001929_abnormal_gametogenesis1.21541166
94MP0003693_abnormal_embryo_hatching1.21463615
95MP0003690_abnormal_glial_cell1.20625129
96MP0002210_abnormal_sex_determination1.19026074
97MP0002086_abnormal_extraembryonic_tissu1.18763527
98MP0002733_abnormal_thermal_nociception1.18728129
99MP0008469_abnormal_protein_level1.17740196
100MP0009764_decreased_sensitivity_to1.17734506
101MP0003698_abnormal_male_reproductive1.15152719
102MP0008004_abnormal_stomach_pH1.14982147
103MP0005167_abnormal_blood-brain_barrier1.14022875
104MP0002063_abnormal_learning/memory/cond1.13825015
105MP0001440_abnormal_grooming_behavior1.11246857
106MP0001697_abnormal_embryo_size1.10661637
107MP0002085_abnormal_embryonic_tissue1.09758700
108MP0005164_abnormal_response_to1.08945550
109MP0005380_embryogenesis_phenotype1.07941839
110MP0001672_abnormal_embryogenesis/_devel1.07941839
111MP0004036_abnormal_muscle_relaxation1.07102096
112MP0002080_prenatal_lethality1.05517413
113MP0003453_abnormal_keratinocyte_physiol1.05394344
114MP0004087_abnormal_muscle_fiber1.04917529
115MP0003172_abnormal_lysosome_physiology1.04163872
116MP0005166_decreased_susceptibility_to1.03930804
117MP0005409_darkened_coat_color1.03650927
118MP0003119_abnormal_digestive_system1.03204896
119MP0003786_premature_aging1.03003412
120MP0003984_embryonic_growth_retardation1.02248707
121MP0001849_ear_inflammation1.02049762
122MP0002088_abnormal_embryonic_growth/wei1.01409849
123MP0000534_abnormal_ureter_morphology1.00808503
124MP0003567_abnormal_fetal_cardiomyocyte0.99871716
125MP0010630_abnormal_cardiac_muscle0.98647215
126MP0009780_abnormal_chondrocyte_physiolo0.98248938
127MP0008770_decreased_survivor_rate0.97040728
128MP0000350_abnormal_cell_proliferation0.96831421
129MP0004808_abnormal_hematopoietic_stem0.96087363
130MP0002064_seizures0.94222180
131MP0004185_abnormal_adipocyte_glucose0.93220391
132MP0000537_abnormal_urethra_morphology0.92323072
133MP0009046_muscle_twitch0.91970802
134MP0008874_decreased_physiological_sensi0.90377009
135MP0000653_abnormal_sex_gland0.90137814
136MP0001727_abnormal_embryo_implantation0.88074328
137MP0005666_abnormal_adipose_tissue0.87998700
138MP0003077_abnormal_cell_cycle0.87395495
139MP0003828_pulmonary_edema0.87319655
140MP0000428_abnormal_craniofacial_morphol0.87055084
141MP0008057_abnormal_DNA_replication0.87033153
142MP0001970_abnormal_pain_threshold0.85715422
143MP0004130_abnormal_muscle_cell0.85681333
144MP0003656_abnormal_erythrocyte_physiolo0.85619611
145MP0000490_abnormal_crypts_of0.85003520
146MP0003861_abnormal_nervous_system0.82903444
147MP0003448_altered_tumor_morphology0.82713061
148MP0000955_abnormal_spinal_cord0.82400511
149MP0010094_abnormal_chromosome_stability0.82288800
150MP0003300_gastrointestinal_ulcer0.82238653
151MP0004264_abnormal_extraembryonic_tissu0.82061567
152MP0000358_abnormal_cell_content/0.82018876
153MP0001663_abnormal_digestive_system0.81971700
154MP0003115_abnormal_respiratory_system0.80891441
155MP0002396_abnormal_hematopoietic_system0.80840645
156MP0006138_congestive_heart_failure0.79560662
157MP0000604_amyloidosis0.79534616
158MP0002133_abnormal_respiratory_system0.79154448
159MP0005388_respiratory_system_phenotype0.79154448
160MP0003091_abnormal_cell_migration0.77268532
161MP0005248_abnormal_Harderian_gland0.76995539
162MP0000733_abnormal_muscle_development0.76108624
163MP0005390_skeleton_phenotype0.76093276
164MP0002332_abnormal_exercise_endurance0.73109011
165MP0001968_abnormal_touch/_nociception0.72630372
166MP0002152_abnormal_brain_morphology0.72284327
167MP0001661_extended_life_span0.72128393
168MP0002161_abnormal_fertility/fecundity0.72074102
169MP0005330_cardiomyopathy0.71728237
170MP0005187_abnormal_penis_morphology0.71260412
171MP0004484_altered_response_of0.69972808
172MP0001873_stomach_inflammation0.68612636
173MP0000678_abnormal_parathyroid_gland0.68286808
174MP0000343_altered_response_to0.66888725
175MP0000015_abnormal_ear_pigmentation0.65320594
176MP0005083_abnormal_biliary_tract0.63110312
177MP0000249_abnormal_blood_vessel0.61018869
178MP0003795_abnormal_bone_structure0.56432649
179MP0003221_abnormal_cardiomyocyte_apopto0.56302706

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.65463678
2Recurrent abscess formation (HP:0002722)5.68425306
3Recurrent bacterial skin infections (HP:0005406)5.54649023
4Myositis (HP:0100614)5.22111978
5Orchitis (HP:0100796)5.07851064
6Abnormality of macrophages (HP:0004311)4.82637488
7Optic neuritis (HP:0100653)4.62959822
8Retrobulbar optic neuritis (HP:0100654)4.62959822
9Recurrent gram-negative bacterial infections (HP:0005420)4.47646588
10Abnormality of the lower motor neuron (HP:0002366)4.45861763
11Hyperacusis (HP:0010780)4.04712568
12Spontaneous hematomas (HP:0007420)3.94258688
13Stomatitis (HP:0010280)3.83811242
14Hand muscle atrophy (HP:0009130)3.68743679
15Obstructive lung disease (HP:0006536)3.66958340
16Chronic obstructive pulmonary disease (HP:0006510)3.66958340
17Gastrointestinal infarctions (HP:0005244)3.61248243
18Insomnia (HP:0100785)3.60986250
19Gingivitis (HP:0000230)3.60690616
20Elevated erythrocyte sedimentation rate (HP:0003565)3.58841126
21Recurrent fungal infections (HP:0002841)3.54709491
22Mediastinal lymphadenopathy (HP:0100721)3.46777249
23Recurrent skin infections (HP:0001581)3.45093828
24Keratoconjunctivitis sicca (HP:0001097)3.41354246
25Cerebral aneurysm (HP:0004944)3.39161367
26Ependymoma (HP:0002888)3.37400325
27Male infertility (HP:0003251)3.35768685
28Increased IgE level (HP:0003212)3.31832419
29Visual hallucinations (HP:0002367)3.31755382
30Upper limb amyotrophy (HP:0009129)3.30760061
31Distal upper limb amyotrophy (HP:0007149)3.30760061
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.25705226
33Meningitis (HP:0001287)3.23186636
34Hypochromic microcytic anemia (HP:0004840)3.23131714
35Cellulitis (HP:0100658)3.15812986
36Keratoconjunctivitis (HP:0001096)3.10672890
37Prolonged bleeding time (HP:0003010)3.05630927
38Urticaria (HP:0001025)3.04881459
39Astrocytoma (HP:0009592)3.04118285
40Abnormality of the astrocytes (HP:0100707)3.04118285
41Elfin facies (HP:0004428)2.98548281
42Annular pancreas (HP:0001734)2.95724874
43Encephalitis (HP:0002383)2.90448338
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.89571901
45Chronic mucocutaneous candidiasis (HP:0002728)2.79468046
46Recurrent cutaneous fungal infections (HP:0011370)2.79468046
47Myokymia (HP:0002411)2.79026598
48Episodic fever (HP:0001954)2.76589093
49Hypochromic anemia (HP:0001931)2.76457071
50Bowel diverticulosis (HP:0005222)2.74237440
51Pointed chin (HP:0000307)2.73732452
52Renovascular hypertension (HP:0100817)2.73483828
53Vasculitis (HP:0002633)2.73248757
54Chest pain (HP:0100749)2.71553673
55Nasal polyposis (HP:0100582)2.70226303
56Slow saccadic eye movements (HP:0000514)2.68828288
57Testicular neoplasm (HP:0010788)2.67717066
58Gastrointestinal inflammation (HP:0004386)2.65361933
59Difficulty climbing stairs (HP:0003551)2.64193131
60Inflammation of the large intestine (HP:0002037)2.64174559
61Ankle clonus (HP:0011448)2.60359804
62Arterial thrombosis (HP:0004420)2.59447268
63Overriding aorta (HP:0002623)2.56218236
64Renal duplication (HP:0000075)2.52648143
65Missing ribs (HP:0000921)2.52532302
66Hemiplegia (HP:0002301)2.51587086
67Amyloidosis (HP:0011034)2.51532960
68Abnormality of the nasal mucosa (HP:0000433)2.50005291
69Dysmetric saccades (HP:0000641)2.47201887
70Hemoptysis (HP:0002105)2.47195433
71Peritonitis (HP:0002586)2.46542878
72Ankle contracture (HP:0006466)2.42849813
73Epistaxis (HP:0000421)2.41998539
74Gonadal dysgenesis (HP:0000133)2.41895093
75T lymphocytopenia (HP:0005403)2.40159913
76Gingival bleeding (HP:0000225)2.36691209
77Segmental peripheral demyelination/remyelination (HP:0003481)2.33818095
78Pulmonary embolism (HP:0002204)2.33088896
79Selective tooth agenesis (HP:0001592)2.32653289
80Osteomyelitis (HP:0002754)2.32334403
81Petechiae (HP:0000967)2.31651794
82Subacute progressive viral hepatitis (HP:0006572)2.30320546
83Difficulty running (HP:0009046)2.29755499
84Amyotrophic lateral sclerosis (HP:0007354)2.29595377
85Papilledema (HP:0001085)2.27076607
86Supranuclear gaze palsy (HP:0000605)2.26675575
87Obstructive sleep apnea (HP:0002870)2.26433484
88Hyporeflexia of lower limbs (HP:0002600)2.25692184
89Pustule (HP:0200039)2.23596649
90Metaphyseal cupping (HP:0003021)2.22609765
91Abnormality of T cell number (HP:0011839)2.21710477
92Apathy (HP:0000741)2.21182721
93Colitis (HP:0002583)2.20143592
94Anorexia (HP:0002039)2.19473867
95Adenoma sebaceum (HP:0009720)2.18989733
96Angiofibromas (HP:0010615)2.18989733
97Increased cerebral lipofuscin (HP:0011813)2.18944648
98Ventricular fibrillation (HP:0001663)2.17899301
99Enlarged penis (HP:0000040)2.17138375
100Pulmonary infiltrates (HP:0002113)2.15908195
101Microcytic anemia (HP:0001935)2.15157361
102Resting tremor (HP:0002322)2.14102587
103Fibrous tissue neoplasm (HP:0012316)2.13606452
104Rectal prolapse (HP:0002035)2.13511853
105Polycythemia (HP:0001901)2.13293851
106Gonadotropin excess (HP:0000837)2.12733778
107Leukocytosis (HP:0001974)2.12327611
108Recurrent viral infections (HP:0004429)2.10619092
109Fibroma (HP:0010614)2.08685262
110Rapidly progressive (HP:0003678)2.07664371
111Colon cancer (HP:0003003)2.07244085
112Focal seizures (HP:0007359)2.06097498
113Glioma (HP:0009733)2.05705666
114Bladder diverticulum (HP:0000015)2.05209572
115Bundle branch block (HP:0011710)2.04848357
116Sepsis (HP:0100806)2.04707760
117Premature loss of primary teeth (HP:0006323)2.04354864
118Flat cornea (HP:0007720)2.03862297
119Interstitial pulmonary disease (HP:0006530)2.01757202
120EMG: neuropathic changes (HP:0003445)2.01751698
121Genu recurvatum (HP:0002816)2.01457856
122Abnormality of the peritoneum (HP:0002585)2.00612324
123Abnormality of the fingertips (HP:0001211)2.00132115
124Abnormality of the diencephalon (HP:0010662)1.99141557
125High pitched voice (HP:0001620)1.98518989
126Neoplasm of the oral cavity (HP:0100649)1.98094044
127Abnormality of the endocardium (HP:0004306)1.97533783
128Global brain atrophy (HP:0002283)1.97344606
129Spinal muscular atrophy (HP:0007269)1.97173752
130Acne (HP:0001061)1.92666869
131Increased variability in muscle fiber diameter (HP:0003557)1.92482979
132Action tremor (HP:0002345)1.92232505
133Diminished motivation (HP:0000745)1.91281852
134Achilles tendon contracture (HP:0001771)1.90776157
135Heterotopia (HP:0002282)1.90249652
136Shallow orbits (HP:0000586)1.88531238
137Increased nuchal translucency (HP:0010880)1.87807679
138Vertigo (HP:0002321)1.87015172
139Myopathic facies (HP:0002058)1.85617875
140Viral hepatitis (HP:0006562)1.85553868
14111 pairs of ribs (HP:0000878)1.85167107
142Hypercortisolism (HP:0001578)1.84797186
143Granulocytopenia (HP:0001913)1.84360667
144Basal cell carcinoma (HP:0002671)1.83746175
145Hypoventilation (HP:0002791)1.83416894
146Loss of speech (HP:0002371)1.81826638
147Chronic otitis media (HP:0000389)1.81767531
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.81619798
149Diaphragmatic weakness (HP:0009113)1.81016794
150Depression (HP:0000716)1.80751115
151Abnormality of T cells (HP:0002843)1.80089625
152Abnormality of ocular smooth pursuit (HP:0000617)1.79948142
153Abnormality of the musculature of the hand (HP:0001421)1.79862899
154Facial diplegia (HP:0001349)1.78534489
155Hemorrhage of the eye (HP:0011885)1.77759386
156Urinary urgency (HP:0000012)1.77373282
157Polygenic inheritance (HP:0010982)1.76946973
158Abnormality of the pleura (HP:0002103)1.76273728
159Skin ulcer (HP:0200042)1.75247138
160Gangrene (HP:0100758)1.74279095
161Back pain (HP:0003418)1.74090286
162Purpura (HP:0000979)1.73923072
163Recurrent sinusitis (HP:0011108)1.73741373
164Abnormality of glycolipid metabolism (HP:0010969)1.73569894
165Abnormality of liposaccharide metabolism (HP:0010968)1.73569894
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.73569894
167Megalocornea (HP:0000485)1.72631184
168Macroorchidism (HP:0000053)1.72437814
169Lymphangioma (HP:0100764)1.72096051
170Abnormal vertebral ossification (HP:0100569)1.71920230
171Impaired smooth pursuit (HP:0007772)1.71659844
172Broad palm (HP:0001169)1.71630781
173Lymphopenia (HP:0001888)1.70778192
174Abnormality of the vocal cords (HP:0008777)1.70689540
175Pathologic fracture (HP:0002756)1.70685219
176Hypermelanotic macule (HP:0001034)1.70630500
177Abnormal platelet volume (HP:0011876)1.70255795
178Fasciculations (HP:0002380)1.69734254
179Glomerulopathy (HP:0100820)1.68708912
180Generalized tonic-clonic seizures (HP:0002069)1.68373042
181Mutism (HP:0002300)1.67334784
182Neuronal loss in central nervous system (HP:0002529)1.67198397
183Postural instability (HP:0002172)1.66516843
184Bronchomalacia (HP:0002780)1.65992166
185Increased connective tissue (HP:0009025)1.65755902
186Shoulder girdle muscle weakness (HP:0003547)1.63936377
187Mesangial abnormality (HP:0001966)1.63834199
188Biliary tract neoplasm (HP:0100574)1.62625193
189Germ cell neoplasia (HP:0100728)1.62376477
190Abnormality of skeletal muscle fiber size (HP:0012084)1.62351534
191Protrusio acetabuli (HP:0003179)1.61853991
192Neoplasm of the peripheral nervous system (HP:0100007)1.61420868
193Ulnar deviation of the wrist (HP:0003049)1.61039444
194Pelvic girdle muscle weakness (HP:0003749)1.60949084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.42842789
2EEF2K4.30007980
3TRIB33.21092652
4ERN13.01425906
5IRAK42.94645768
6SCYL22.86478927
7BLK2.85503416
8MAP3K92.77913508
9CDK122.75982025
10PRPF4B2.69414540
11PKN22.62454050
12CSK2.55514025
13TYRO32.46216648
14PRKD32.26972205
15FES2.26740515
16EPHB12.23026329
17TYK22.11113621
18ICK2.04987333
19GRK61.99335534
20PNCK1.96383456
21TNK21.96055563
22MAP3K31.89235744
23NEK11.88610347
24MAPKAPK31.87854341
25LATS21.87415322
26NEK21.86433645
27RIPK11.85972657
28ZAP701.81268755
29MARK21.61160029
30KSR21.58448148
31FGR1.57613275
32ALK1.55031356
33PDK31.54272286
34PDK41.54272286
35NTRK31.54174191
36SIK21.54051685
37HCK1.51578191
38PDGFRA1.48107325
39SMG11.47629331
40MINK11.47088818
41MAP3K131.46804141
42CAMKK11.43041531
43MAP3K101.42621462
44MAP3K41.40367020
45MAP3K21.39466423
46BTK1.37450831
47WEE11.35231257
48IRAK21.34265124
49SIK11.31502612
50JAK31.30141230
51JAK21.23763067
52STK381.23643940
53DAPK21.20489284
54KDR1.19311356
55NTRK11.15857347
56PAK41.15494694
57PTK21.13607389
58TTN1.13558111
59PTK61.10855643
60LMTK21.10611698
61MAP3K141.09187129
62PAK61.09099280
63YES11.08679251
64IRAK11.08409794
65SYK1.07962627
66RET1.06847430
67RPS6KB21.03782526
68EPHA21.03034073
69TAOK21.02358802
70MTOR1.00849091
71TBK10.99263934
72IKBKE0.98728064
73CDK190.97341035
74TAOK10.94279225
75LYN0.93798087
76PRKD20.93593900
77CDC70.91332922
78PHKG10.91114037
79PHKG20.91114037
80JAK10.90511557
81MARK30.89643930
82RPS6KA20.89184065
83TXK0.88560598
84DAPK10.87953497
85BRD40.84191937
86MAP3K70.83895312
87PRKG20.83763743
88CDK70.82516247
89SIK30.81727544
90MAP2K40.80347539
91PTK2B0.79434560
92FGFR40.78590317
93MARK10.78560673
94MAPK120.77300991
95TTK0.77179643
96MAP3K60.76832621
97LCK0.75734411
98DYRK30.73807796
99CDC42BPA0.71434997
100DMPK0.70459193
101BMX0.70080870
102WNK10.68779561
103MAP3K110.67303766
104PAK20.67275914
105TSSK60.67142960
106STK100.66457857
107PDK20.65898653
108NTRK20.65444750
109IRAK30.64746931
110DDR20.63038492
111CDK40.62591752
112KSR10.62442829
113ITK0.61287496
114FYN0.60627482
115CSF1R0.59766626
116STK110.58462874
117FGFR30.58198789
118SGK20.58000706
119CAMK1G0.57681211
120FLT30.57426210
121HIPK20.56430221
122CDK60.55859973
123MAP3K10.52051955
124MAP3K80.51801456
125FER0.51215343
126GRK50.50738833
127MATK0.49826699
128SGK30.49500805
129RPS6KC10.49099930
130RPS6KL10.49099930
131DYRK1B0.46939300
132LRRK20.46846880
133TGFBR20.46135184
134PDK10.45656868
135CSNK1E0.44404560
136CDK50.43538041
137ARAF0.43215331
138MAP2K70.43059237
139WNK30.42710847
140PLK10.42666528
141BMPR20.42505264
142CDK20.42041521
143CAMK40.41975215
144PRKCI0.39689961
145PRKCG0.38704374
146CAMK1D0.38691695
147SGK2230.38557546
148SGK4940.38557546
149MAPK100.37486498
150TAOK30.37076756
151RPS6KA60.36932435
152PAK30.35836729
153TESK20.35448653
154MAP3K50.34937652
155UHMK10.34801571
156MAP2K60.34794947
157MAP2K30.34784640
158CHEK10.34622202
159MAPK70.34389236
160RAF10.34387759
161MAPK80.33787364
162MAP4K10.32467163
163CSNK1G20.31512786
164CDK11A0.29098468
165PRKCH0.29024203
166PDPK10.28230496

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.78652169
2Osteoclast differentiation_Homo sapiens_hsa043802.67325367
3Leishmaniasis_Homo sapiens_hsa051402.38353548
4B cell receptor signaling pathway_Homo sapiens_hsa046622.09426221
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99109040
6Staphylococcus aureus infection_Homo sapiens_hsa051501.90758175
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89837556
8Tuberculosis_Homo sapiens_hsa051521.89612739
9Acute myeloid leukemia_Homo sapiens_hsa052211.86173368
10Long-term potentiation_Homo sapiens_hsa047201.83113141
11Dorso-ventral axis formation_Homo sapiens_hsa043201.76262822
12Synaptic vesicle cycle_Homo sapiens_hsa047211.70023184
13Olfactory transduction_Homo sapiens_hsa047401.69813339
14Estrogen signaling pathway_Homo sapiens_hsa049151.69579054
15mTOR signaling pathway_Homo sapiens_hsa041501.65931161
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65295045
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62278932
18Oocyte meiosis_Homo sapiens_hsa041141.61801941
19Gastric acid secretion_Homo sapiens_hsa049711.59665385
20Malaria_Homo sapiens_hsa051441.58218158
21Chemokine signaling pathway_Homo sapiens_hsa040621.57670029
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.49187506
23Glioma_Homo sapiens_hsa052141.47482739
24T cell receptor signaling pathway_Homo sapiens_hsa046601.46645630
25VEGF signaling pathway_Homo sapiens_hsa043701.43400321
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43357456
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42548875
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42058469
29Measles_Homo sapiens_hsa051621.40476390
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39800204
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39137441
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38693011
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.32123545
34Gap junction_Homo sapiens_hsa045401.31529676
35Renin secretion_Homo sapiens_hsa049241.31048097
36Toxoplasmosis_Homo sapiens_hsa051451.28972764
37GnRH signaling pathway_Homo sapiens_hsa049121.27132060
38Influenza A_Homo sapiens_hsa051641.26451203
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25694542
40Oxytocin signaling pathway_Homo sapiens_hsa049211.25172253
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.22923471
42Amphetamine addiction_Homo sapiens_hsa050311.22404702
43Pancreatic cancer_Homo sapiens_hsa052121.22034464
44Salivary secretion_Homo sapiens_hsa049701.21466736
45Hepatitis C_Homo sapiens_hsa051601.21433981
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19098894
47TNF signaling pathway_Homo sapiens_hsa046681.17520649
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.17407221
49Phagosome_Homo sapiens_hsa041451.16991950
50Graft-versus-host disease_Homo sapiens_hsa053321.16465338
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16295940
52Circadian entrainment_Homo sapiens_hsa047131.15886040
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.15357438
54Glucagon signaling pathway_Homo sapiens_hsa049221.14949727
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13600867
56Legionellosis_Homo sapiens_hsa051341.11387234
57African trypanosomiasis_Homo sapiens_hsa051431.11176748
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10885099
59Allograft rejection_Homo sapiens_hsa053301.10571479
60Dopaminergic synapse_Homo sapiens_hsa047281.10490741
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10317720
62Hepatitis B_Homo sapiens_hsa051611.10074233
63Endometrial cancer_Homo sapiens_hsa052131.07869169
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07593772
65Autoimmune thyroid disease_Homo sapiens_hsa053201.06836425
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06806684
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05802762
68Other glycan degradation_Homo sapiens_hsa005111.05029384
69RNA transport_Homo sapiens_hsa030131.03786897
70Insulin secretion_Homo sapiens_hsa049111.02774391
71Hematopoietic cell lineage_Homo sapiens_hsa046401.02340564
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02168531
73Insulin signaling pathway_Homo sapiens_hsa049101.01529765
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00497619
75Apoptosis_Homo sapiens_hsa042101.00054815
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99020297
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.98590097
78Non-small cell lung cancer_Homo sapiens_hsa052230.97983091
79AMPK signaling pathway_Homo sapiens_hsa041520.97940872
80Colorectal cancer_Homo sapiens_hsa052100.97870327
81Prolactin signaling pathway_Homo sapiens_hsa049170.97353230
82Glutamatergic synapse_Homo sapiens_hsa047240.97293268
83Focal adhesion_Homo sapiens_hsa045100.96033532
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95583477
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95396018
86Chronic myeloid leukemia_Homo sapiens_hsa052200.94628135
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94479838
88Salmonella infection_Homo sapiens_hsa051320.94208352
89Primary immunodeficiency_Homo sapiens_hsa053400.92447129
90DNA replication_Homo sapiens_hsa030300.91100857
91mRNA surveillance pathway_Homo sapiens_hsa030150.90760457
92cAMP signaling pathway_Homo sapiens_hsa040240.89716250
93Hippo signaling pathway_Homo sapiens_hsa043900.89550506
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89389841
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.89191948
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87555425
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87119261
98Mismatch repair_Homo sapiens_hsa034300.86470096
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85835017
100Herpes simplex infection_Homo sapiens_hsa051680.85697912
101Calcium signaling pathway_Homo sapiens_hsa040200.84745738
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84341194
103Hedgehog signaling pathway_Homo sapiens_hsa043400.84012918
104Cholinergic synapse_Homo sapiens_hsa047250.83269369
105Melanogenesis_Homo sapiens_hsa049160.82784894
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82599613
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82468948
108Inositol phosphate metabolism_Homo sapiens_hsa005620.82419163
109ErbB signaling pathway_Homo sapiens_hsa040120.81642947
110Dilated cardiomyopathy_Homo sapiens_hsa054140.81546797
111Viral myocarditis_Homo sapiens_hsa054160.81267622
112Insulin resistance_Homo sapiens_hsa049310.81023295
113GABAergic synapse_Homo sapiens_hsa047270.80923318
114Antigen processing and presentation_Homo sapiens_hsa046120.80450121
115FoxO signaling pathway_Homo sapiens_hsa040680.80307160
116Shigellosis_Homo sapiens_hsa051310.79818596
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79625352
118Type II diabetes mellitus_Homo sapiens_hsa049300.79450329
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.75902827
120Endocytosis_Homo sapiens_hsa041440.75720963
121Thyroid hormone synthesis_Homo sapiens_hsa049180.75673866
122Proteoglycans in cancer_Homo sapiens_hsa052050.75646369
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75051143
124Amoebiasis_Homo sapiens_hsa051460.75000536
125Fatty acid biosynthesis_Homo sapiens_hsa000610.74658094
126Choline metabolism in cancer_Homo sapiens_hsa052310.74466482
127Nicotine addiction_Homo sapiens_hsa050330.74034904
128Tight junction_Homo sapiens_hsa045300.73991608
129Pertussis_Homo sapiens_hsa051330.73256162
130Small cell lung cancer_Homo sapiens_hsa052220.72938411
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72592687
132Long-term depression_Homo sapiens_hsa047300.72455726
133Rap1 signaling pathway_Homo sapiens_hsa040150.71106383
134HIF-1 signaling pathway_Homo sapiens_hsa040660.70853756
135ECM-receptor interaction_Homo sapiens_hsa045120.70499796
136Renal cell carcinoma_Homo sapiens_hsa052110.69025413
137Platelet activation_Homo sapiens_hsa046110.68667654
138Lysosome_Homo sapiens_hsa041420.68543342
139Type I diabetes mellitus_Homo sapiens_hsa049400.67189364
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67035404
141Thyroid cancer_Homo sapiens_hsa052160.66927994
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66905917
143Notch signaling pathway_Homo sapiens_hsa043300.66786157
144Fructose and mannose metabolism_Homo sapiens_hsa000510.66088066
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65887118
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.63377278
147MAPK signaling pathway_Homo sapiens_hsa040100.62661974
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62628818
149Viral carcinogenesis_Homo sapiens_hsa052030.60136168
150Morphine addiction_Homo sapiens_hsa050320.60074377
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59782355
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59160123
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.58733229
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58240028
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.56646267
156Prostate cancer_Homo sapiens_hsa052150.56209845
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54528114
158Ras signaling pathway_Homo sapiens_hsa040140.50264035

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