SLC45A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ketone body metabolic process (GO:1902224)9.98682090
2* secondary metabolic process (GO:0019748)9.94482772
3melanocyte differentiation (GO:0030318)8.27905020
4* developmental pigmentation (GO:0048066)7.92171076
5pigment cell differentiation (GO:0050931)7.54171749
6melanosome organization (GO:0032438)7.35738962
7* pigment biosynthetic process (GO:0046148)7.14464617
8pigment granule organization (GO:0048753)6.99574773
9regulation of endothelial cell chemotaxis (GO:2001026)6.12862597
10myotube differentiation (GO:0014902)5.60320671
11* pigment metabolic process (GO:0042440)5.51437561
12mesenchymal-epithelial cell signaling (GO:0060638)5.46458306
13endosome to pigment granule transport (GO:0043485)5.42674043
14endosome to melanosome transport (GO:0035646)5.42674043
15negative regulation of hydrogen peroxide-induced cell death (GO:1903206)5.33636942
16neuroepithelial cell differentiation (GO:0060563)5.32046939
17melanosome transport (GO:0032402)5.26119618
18calcium-mediated signaling using intracellular calcium source (GO:0035584)5.19642568
19regulation of superoxide anion generation (GO:0032928)5.12456556
20pigment granule transport (GO:0051904)5.07584673
21regulation of integrin-mediated signaling pathway (GO:2001044)5.05522455
22establishment of melanosome localization (GO:0032401)4.99944311
23melanosome localization (GO:0032400)4.98963697
24positive regulation of neuroblast proliferation (GO:0002052)4.95923453
25short-chain fatty acid metabolic process (GO:0046459)4.85806706
26negative regulation of response to reactive oxygen species (GO:1901032)4.84876240
27pigment granule localization (GO:0051875)4.83739183
28establishment of pigment granule localization (GO:0051905)4.83353291
29regulation of hydrogen peroxide-induced cell death (GO:1903205)4.79219258
30aromatic amino acid family metabolic process (GO:0009072)4.71097986
31negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.57464032
32regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.43454811
33negative regulation of interleukin-1 beta production (GO:0032691)4.41146720
34endothelial cell morphogenesis (GO:0001886)4.20155276
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.14252864
36response to epinephrine (GO:0071871)4.04209086
37nerve growth factor signaling pathway (GO:0038180)4.04121737
38* melanin biosynthetic process (GO:0042438)32.9741383
39positive regulation of receptor recycling (GO:0001921)3.86274932
40* phenol-containing compound metabolic process (GO:0018958)3.74007088
41semaphorin-plexin signaling pathway (GO:0071526)3.70190446
42somatic stem cell division (GO:0048103)3.53491297
43inositol phosphate catabolic process (GO:0071545)3.50048038
44negative regulation of interleukin-1 production (GO:0032692)3.49765852
45regulation of neuroblast proliferation (GO:1902692)3.46674281
46mitotic G1 DNA damage checkpoint (GO:0031571)3.44232398
47stress fiber assembly (GO:0043149)3.39329680
48negative regulation of chemokine production (GO:0032682)3.38901084
49regulation of superoxide metabolic process (GO:0090322)3.36643078
50* pigmentation (GO:0043473)3.26171220
51cellular response to thyroid hormone stimulus (GO:0097067)3.22582105
52regulation of cellular respiration (GO:0043457)3.21044760
53inositol phosphate dephosphorylation (GO:0046855)3.20957521
54enteric nervous system development (GO:0048484)3.19719706
55signal peptide processing (GO:0006465)3.19288882
56negative regulation of JUN kinase activity (GO:0043508)3.18729670
57muscle cell migration (GO:0014812)3.17702600
58columnar/cuboidal epithelial cell differentiation (GO:0002065)3.17369847
59negative regulation of acute inflammatory response (GO:0002674)3.16733076
60fusion of sperm to egg plasma membrane (GO:0007342)3.13164639
61acrosome reaction (GO:0007340)3.11084488
62regulation of somitogenesis (GO:0014807)3.09568533
63barbed-end actin filament capping (GO:0051016)3.09137007
64response to thyroid hormone (GO:0097066)3.05170354
65* melanin metabolic process (GO:0006582)29.6530155
66* secondary metabolite biosynthetic process (GO:0044550)26.9265726
67mitotic G1/S transition checkpoint (GO:0044819)2.98366728
68G1 DNA damage checkpoint (GO:0044783)2.94509152
69fibroblast migration (GO:0010761)2.91957982
70cullin deneddylation (GO:0010388)2.80795620
71dosage compensation (GO:0007549)2.80214882
72regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.79397125
73proline transport (GO:0015824)2.79188128
74negative regulation of organelle assembly (GO:1902116)2.78999947
75polyol catabolic process (GO:0046174)2.77124376
76piRNA metabolic process (GO:0034587)2.76282140
77bone remodeling (GO:0046849)2.71578773
78cellular response to reactive nitrogen species (GO:1902170)2.71215503
79regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.68117622
80cellular response to nitric oxide (GO:0071732)2.66884213
81Rap protein signal transduction (GO:0032486)2.65195260
82response to muscle activity (GO:0014850)2.65000981
83behavioral response to ethanol (GO:0048149)2.61623121
84retinal rod cell development (GO:0046548)2.61362729
85regulation of response to reactive oxygen species (GO:1901031)2.59740960
86negative regulation of oxidative stress-induced cell death (GO:1903202)2.58976391
87basement membrane organization (GO:0071711)2.58596541
88peripheral nervous system development (GO:0007422)2.58539002
89galactose metabolic process (GO:0006012)2.57862189
90intracellular pH reduction (GO:0051452)2.57414789
91negative regulation of receptor-mediated endocytosis (GO:0048261)2.57353639
92proteasome assembly (GO:0043248)2.55015966
93negative regulation of TOR signaling (GO:0032007)2.54891368
94plasma membrane fusion (GO:0045026)2.51007715
95positive regulation of neural precursor cell proliferation (GO:2000179)2.50081617
96negative regulation of cellular response to oxidative stress (GO:1900408)2.48910730
97negative regulation of response to oxidative stress (GO:1902883)2.48910730
98negative regulation of fatty acid biosynthetic process (GO:0045717)2.46389887
99muscle cell cellular homeostasis (GO:0046716)2.43425526
100Rac protein signal transduction (GO:0016601)2.41701493
101protein deneddylation (GO:0000338)2.40965748
102inner mitochondrial membrane organization (GO:0007007)2.40017767
103regulation of DNA endoreduplication (GO:0032875)2.39541368
104cellular response to nerve growth factor stimulus (GO:1990090)2.38344199
105response to nerve growth factor (GO:1990089)2.38344199
106regulation of clathrin-mediated endocytosis (GO:2000369)2.38060660
107sialylation (GO:0097503)2.34419458
108regulation of centriole replication (GO:0046599)2.33404115
109removal of superoxide radicals (GO:0019430)2.33106603
110cellular response to superoxide (GO:0071451)2.33106603
111cellular response to oxygen radical (GO:0071450)2.33106603
112negative regulation of transcription by competitive promoter binding (GO:0010944)2.32627121
113vesicle localization (GO:0051648)2.32365546
114regulation of receptor recycling (GO:0001919)2.31259913
115response to nitric oxide (GO:0071731)2.30251488
116positive regulation of response to oxidative stress (GO:1902884)2.30217208
117positive regulation of cellular response to oxidative stress (GO:1900409)2.30217208
118dendritic spine organization (GO:0097061)2.29765686
119glutathione derivative metabolic process (GO:1901685)2.28446016
120glutathione derivative biosynthetic process (GO:1901687)2.28446016
121autophagic vacuole fusion (GO:0000046)2.28375284
122antigen processing and presentation via MHC class Ib (GO:0002475)2.28343591
123gluconeogenesis (GO:0006094)2.27181701
124regulation of protein sumoylation (GO:0033233)2.26526085
125stem cell division (GO:0017145)2.26298283
1264-hydroxyproline metabolic process (GO:0019471)2.24280283
127establishment of nucleus localization (GO:0040023)2.23358929
128regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.21911331
129osteoclast differentiation (GO:0030316)2.17559671
130negative regulation of fatty acid metabolic process (GO:0045922)2.03201346
131positive regulation of glucose transport (GO:0010828)2.02781379
132myelin assembly (GO:0032288)2.00623061
133tyrosine metabolic process (GO:0006570)15.0770116
134* phenol-containing compound biosynthetic process (GO:0046189)10.2412307
135regulation of early endosome to late endosome transport (GO:2000641)1.97451783
136* organic hydroxy compound biosynthetic process (GO:1901617)1.97263029
137folic acid-containing compound biosynthetic process (GO:0009396)1.96819627
138regulation of apoptotic cell clearance (GO:2000425)1.96185229
139cellular glucuronidation (GO:0052695)1.95339307
140positive chemotaxis (GO:0050918)1.90746585
141peptidyl-lysine dimethylation (GO:0018027)1.89242492
142establishment of mitotic spindle orientation (GO:0000132)1.88513737
143centrosome duplication (GO:0051298)1.88358639
144protein K6-linked ubiquitination (GO:0085020)1.86322026
145regulation of short-term neuronal synaptic plasticity (GO:0048172)1.85495323
146regulation of oxidative stress-induced cell death (GO:1903201)1.84342890
147negative regulation of histone methylation (GO:0031061)1.83012847
148positive regulation of osteoblast proliferation (GO:0033690)1.77406444
149negative regulation of membrane potential (GO:0045837)1.77051177
150glucuronate metabolic process (GO:0019585)1.74704024
151uronic acid metabolic process (GO:0006063)1.74704024
152positive regulation of Rap GTPase activity (GO:0032854)1.73063350
153organelle membrane fusion (GO:0090174)1.71873754
154glycolytic process (GO:0006096)1.71260397
155specification of organ identity (GO:0010092)1.71152348
156glycoprotein catabolic process (GO:0006516)1.69099271
157regulation of histone H3-K9 methylation (GO:0051570)1.68622889
158spinal cord association neuron differentiation (GO:0021527)1.67178894
159chondroitin sulfate biosynthetic process (GO:0030206)1.66250551
160positive regulation of DNA-dependent DNA replication (GO:2000105)1.65985140
161establishment of mitotic spindle localization (GO:0040001)1.64650591
162regulation of cellular response to oxidative stress (GO:1900407)1.63557385
163glucan biosynthetic process (GO:0009250)1.59686989
164glycogen biosynthetic process (GO:0005978)1.59686989
165centrosome localization (GO:0051642)1.59639694
166regulation of translational fidelity (GO:0006450)1.59512617
167phosphorylated carbohydrate dephosphorylation (GO:0046838)1.58670532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.20114104
2E2F7_22180533_ChIP-Seq_HELA_Human4.60251058
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.35142511
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.12987342
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.78231266
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.78020390
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62212212
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.09228919
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89137123
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.83557269
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80709216
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.69601780
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.57402929
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.54186337
15PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.45481164
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36795654
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23262003
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21818151
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.20466956
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.12860376
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.10200371
22ESR1_15608294_ChIP-ChIP_MCF-7_Human2.08104733
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06836386
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04969567
25RBPJ_22232070_ChIP-Seq_NCS_Mouse10.9632179
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98222696
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.94740190
28* MITF_21258399_ChIP-Seq_MELANOMA_Human1.92607487
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81316645
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.77926987
31CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.73188746
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71795960
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70916148
34GABP_19822575_ChIP-Seq_HepG2_Human1.66641246
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.65604408
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64171224
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63347445
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61971653
39GATA1_22025678_ChIP-Seq_K562_Human1.57723847
40CLOCK_20551151_ChIP-Seq_293T_Human1.53622854
41FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.52102269
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51542068
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50316286
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48505997
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46552881
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45278325
47ZNF263_19887448_ChIP-Seq_K562_Human1.43313084
48DCP1A_22483619_ChIP-Seq_HELA_Human1.42534120
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41437100
50* TFEB_21752829_ChIP-Seq_HELA_Human1.41245984
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38044561
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37774205
53SOX17_20123909_ChIP-Seq_XEN_Mouse1.35810589
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35400006
55AR_21909140_ChIP-Seq_LNCAP_Human1.33466864
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32540491
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29665587
58BRD4_25478319_ChIP-Seq_HGPS_Human1.26094477
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25918491
60ELK1_19687146_ChIP-ChIP_HELA_Human1.25095262
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.24983397
62SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23849205
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.23134507
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23063925
65FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.22731626
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22092753
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21219375
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.20790419
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19873656
70GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.18282683
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17080255
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17080255
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17014631
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16921521
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14651728
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14438072
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14170990
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13881454
79SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.12582066
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.12515434
81FUS_26573619_Chip-Seq_HEK293_Human1.12340214
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11246206
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11018594
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10974370
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.10603476
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.10603476
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10391302
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09507600
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09473436
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09345041
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09228437
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.09008490
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08383637
94TP53_18474530_ChIP-ChIP_U2OS_Human1.06470266
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05963754
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05889887
97FOXP3_21729870_ChIP-Seq_TREG_Human1.05484097
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04935744
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04153389
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01929827
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01670040
102JUN_21703547_ChIP-Seq_K562_Human1.01401785
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01214527
104TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00434600
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99972572
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99893300
107E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99382928
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99234576
109PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99164355
110GATA1_26923725_Chip-Seq_HPCs_Mouse0.98716787
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98204458
112CJUN_26792858_Chip-Seq_BT549_Human0.98138079
113UBF1/2_26484160_Chip-Seq_HMECs_Human0.97304976
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95957326
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94653447
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94061293
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93693942
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.93585071
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93378318
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92885275
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92788605
122MYC_18940864_ChIP-ChIP_HL60_Human0.91999806
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91823462
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91653311
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91365333
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90653782
127BP1_19119308_ChIP-ChIP_Hs578T_Human0.90362195
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.90350765
129ATF3_27146783_Chip-Seq_COLON_Human0.90197630
130VDR_24787735_ChIP-Seq_THP-1_Human0.90192064
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.89902803
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89494520
133FOXM1_23109430_ChIP-Seq_U2OS_Human0.89439390
134AR_25329375_ChIP-Seq_VCAP_Human0.89307516
135RXR_22158963_ChIP-Seq_LIVER_Mouse0.88919552
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.88434940
137PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88335891
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87765775
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87761667
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87501813
141* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87405772
142SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87320402
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87005059
144CTCF_18555785_Chip-Seq_ESCs_Mouse0.86931922
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86253820
146ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85548574
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.85523041
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.85344446
149SOX2_21211035_ChIP-Seq_LN229_Human0.84953549
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.84380509
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.83927028
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83537306
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83205118
154BCAT_22108803_ChIP-Seq_LS180_Human0.83180078
155P300_19829295_ChIP-Seq_ESCs_Human0.82642647
156PU_27001747_Chip-Seq_BMDM_Mouse0.82095859
157OCT1_27270436_Chip-Seq_PROSTATE_Human0.81775152
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.81598655
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81061038
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.80887418
161CRX_20693478_ChIP-Seq_RETINA_Mouse0.80674046
162YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80079446
163VDR_23849224_ChIP-Seq_CD4+_Human0.79561424
164* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78513059
165* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78506154
166SOX2_21211035_ChIP-Seq_LN229_Gbm0.78238982
167EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78228206
168CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78131501
169SMAD3_21741376_ChIP-Seq_EPCs_Human0.77722518
170* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77646878
171TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76546244
172SMAD4_21799915_ChIP-Seq_A2780_Human0.75428346
173GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75369377
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75310243
175KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75296631
176SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74498122
177PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74232674
178NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74189291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000372_irregular_coat_pigmentation9.78489595
2MP0003136_yellow_coat_color5.86627079
3MP0004381_abnormal_hair_follicle4.56919149
4* MP0005408_hypopigmentation4.52136613
5MP0005257_abnormal_intraocular_pressure4.16893472
6* MP0000371_diluted_coat_color4.03225020
7MP0002877_abnormal_melanocyte_morpholog3.68102733
8MP0000015_abnormal_ear_pigmentation3.54598370
9MP0005377_hearing/vestibular/ear_phenot3.38122411
10MP0003878_abnormal_ear_physiology3.38122411
11* MP0002095_abnormal_skin_pigmentation2.83290453
12MP0002102_abnormal_ear_morphology2.81164537
13MP0005075_abnormal_melanosome_morpholog2.68595599
14MP0005174_abnormal_tail_pigmentation2.38181087
15* MP0001324_abnormal_eye_pigmentation2.34580234
16* MP0002075_abnormal_coat/hair_pigmentati2.34050317
17MP0000569_abnormal_digit_pigmentation2.26467131
18MP0005171_absent_coat_pigmentation10.2073949
19MP0003646_muscle_fatigue1.98334117
20MP0002938_white_spotting1.94228922
21MP0005248_abnormal_Harderian_gland1.93181492
22* MP0001186_pigmentation_phenotype1.86712765
23MP0003806_abnormal_nucleotide_metabolis1.86317957
24MP0004885_abnormal_endolymph1.80731206
25MP0002822_catalepsy1.48113751
26MP0002638_abnormal_pupillary_reflex1.47735549
27MP0005197_abnormal_uvea_morphology1.41100147
28MP0003705_abnormal_hypodermis_morpholog1.23542283
29MP0002090_abnormal_vision1.14243584
30MP0005409_darkened_coat_color1.03686060
31MP0010094_abnormal_chromosome_stability0.87377824
32MP0010234_abnormal_vibrissa_follicle0.80582483
33MP0001293_anophthalmia0.76546680
34MP0000733_abnormal_muscle_development0.75104722
35MP0003453_abnormal_keratinocyte_physiol0.67885556
36MP0005058_abnormal_lysosome_morphology0.65510591
37MP0005253_abnormal_eye_physiology0.64173236
38MP0002089_abnormal_postnatal_growth/wei0.62707702
39MP0008260_abnormal_autophagy0.61098357
40MP0001485_abnormal_pinna_reflex0.57536045
41MP0009697_abnormal_copulation0.55045959
42* MP0000367_abnormal_coat/_hair0.53323484
43MP0006054_spinal_hemorrhage0.52632145
44MP0000762_abnormal_tongue_morphology0.50106511
45MP0003186_abnormal_redox_activity0.48965909
46MP0010307_abnormal_tumor_latency0.48596013
47MP0000377_abnormal_hair_follicle0.47792574
48MP0000749_muscle_degeneration0.46741051
49MP0006138_congestive_heart_failure0.46373331
50MP0005023_abnormal_wound_healing0.43220051
51MP0002177_abnormal_outer_ear0.42569068
52MP0003943_abnormal_hepatobiliary_system0.41547341
53MP0002092_abnormal_eye_morphology0.41219904
54MP0003566_abnormal_cell_adhesion0.40176287
55MP0009840_abnormal_foam_cell0.37267386
56MP0005391_vision/eye_phenotype0.36888439
57MP0005623_abnormal_meninges_morphology0.36199025
58MP0005193_abnormal_anterior_eye0.35867832
59MP0003123_paternal_imprinting0.34001527
60MP0001849_ear_inflammation0.32905107
61MP0003191_abnormal_cellular_cholesterol0.30396799
62MP0001984_abnormal_olfaction0.29987769
63MP0000647_abnormal_sebaceous_gland0.29576923
64MP0008770_decreased_survivor_rate0.29410685
65MP0003091_abnormal_cell_migration0.28585638
66MP0005195_abnormal_posterior_eye0.28153348
67MP0003950_abnormal_plasma_membrane0.28097743
68MP0000358_abnormal_cell_content/0.27155480
69MP0008438_abnormal_cutaneous_collagen0.26063379
70MP0004084_abnormal_cardiac_muscle0.25719633
71MP0005551_abnormal_eye_electrophysiolog0.25665636
72MP0004233_abnormal_muscle_weight0.23744521
73MP0003567_abnormal_fetal_cardiomyocyte0.22734111
74MP0009046_muscle_twitch0.22633122
75MP0004924_abnormal_behavior0.22164443
76MP0005386_behavior/neurological_phenoty0.22164443
77MP0006036_abnormal_mitochondrial_physio0.22108618
78MP0001958_emphysema0.21441982
79MP0003172_abnormal_lysosome_physiology0.21436928
80MP0003111_abnormal_nucleus_morphology0.20659127
81MP0002396_abnormal_hematopoietic_system0.20433746
82MP0004197_abnormal_fetal_growth/weight/0.19528343
83MP0002139_abnormal_hepatobiliary_system0.18939147
84MP0008569_lethality_at_weaning0.18380646
85MP0002909_abnormal_adrenal_gland0.17284189
86MP0003634_abnormal_glial_cell0.16506195
87MP0010352_gastrointestinal_tract_polyps0.16400786
88MP0008932_abnormal_embryonic_tissue0.14929119
89MP0004808_abnormal_hematopoietic_stem0.14687237
90MP0001851_eye_inflammation0.14566905
91MP0004484_altered_response_of0.13769224
92MP0001188_hyperpigmentation0.13704438
93MP0002697_abnormal_eye_size0.13105925
94MP0001502_abnormal_circadian_rhythm0.12580987
95MP0002751_abnormal_autonomic_nervous0.11625133
96MP0003385_abnormal_body_wall0.11298900
97MP0002752_abnormal_somatic_nervous0.11135420
98MP0008057_abnormal_DNA_replication0.11105254
99MP0008058_abnormal_DNA_repair0.09791687
100MP0005167_abnormal_blood-brain_barrier0.09093150
101MP0000427_abnormal_hair_cycle0.08676597
102MP0000955_abnormal_spinal_cord0.08506078
103MP0000343_altered_response_to0.07968959
104MP0001299_abnormal_eye_distance/0.07877308
105MP0003718_maternal_effect0.07337320
106MP0001270_distended_abdomen0.06997970
107MP0005164_abnormal_response_to0.06817297
108MP0008007_abnormal_cellular_replicative0.06553745
109MP0002837_dystrophic_cardiac_calcinosis0.06275318
110MP0003011_delayed_dark_adaptation0.06234058
111MP0001963_abnormal_hearing_physiology0.06000894
112MP0004142_abnormal_muscle_tone0.05988863
113MP0003698_abnormal_male_reproductive0.05971129
114MP0009703_decreased_birth_body0.05615042
115MP0001915_intracranial_hemorrhage0.05194900
116MP0003937_abnormal_limbs/digits/tail_de0.04698475
117MP0004147_increased_porphyrin_level0.04691778
118MP0005165_increased_susceptibility_to0.04010543
119MP0003632_abnormal_nervous_system0.03795792
120MP0003938_abnormal_ear_development0.03632414
121MP0005330_cardiomyopathy0.03565267
122MP0000920_abnormal_myelination0.03448798
123MP0000537_abnormal_urethra_morphology0.03122079
124MP0002060_abnormal_skin_morphology0.02941160
125MP0002229_neurodegeneration0.02844773
126MP0000026_abnormal_inner_ear0.02566058
127MP0005083_abnormal_biliary_tract0.02465468
128MP0005187_abnormal_penis_morphology0.01693939
129MP0002269_muscular_atrophy0.01458757
130MP0000747_muscle_weakness0.01411568
131MP0000609_abnormal_liver_physiology-0.0167590
132MP0000681_abnormal_thyroid_gland-0.0164476
133MP0001697_abnormal_embryo_size-0.0163539
134MP0004087_abnormal_muscle_fiber-0.0151972
135MP0005384_cellular_phenotype-0.0122706
136MP0004272_abnormal_basement_membrane-0.0065327
137MP0003077_abnormal_cell_cycle-0.0018537

Predicted human phenotypes

RankGene SetZ-score
1* Aplasia/Hypoplasia of the macula (HP:0008059)9.94306885
2* Blue irides (HP:0000635)9.64244907
3* Aplasia/Hypoplasia affecting the retina (HP:0008061)9.30717391
4* Ocular albinism (HP:0001107)8.28125821
5White forelock (HP:0002211)7.31577858
6* Iris hypopigmentation (HP:0007730)7.21282107
7Subacute progressive viral hepatitis (HP:0006572)7.13687654
8Congenital sensorineural hearing impairment (HP:0008527)7.12920268
9Patchy hypopigmentation of hair (HP:0011365)6.54980038
10Hypoplasia of the iris (HP:0007676)5.81275829
11Cutaneous melanoma (HP:0012056)5.53313964
12* Generalized hypopigmentation (HP:0007513)5.31716083
13* Hypopigmentation of the fundus (HP:0007894)5.29087832
14Heterochromia iridis (HP:0001100)5.19570034
15Freckling (HP:0001480)5.15196326
16Congenital stationary night blindness (HP:0007642)4.80312556
17Bilateral sensorineural hearing impairment (HP:0008619)4.79340134
18Generalized hypopigmentation of hair (HP:0011358)4.77780961
19Premature graying of hair (HP:0002216)4.21665539
20Viral hepatitis (HP:0006562)4.09586545
21Micronodular cirrhosis (HP:0001413)3.95705220
22Albinism (HP:0001022)3.92784374
23Decreased central vision (HP:0007663)3.92014247
24Amblyopia (HP:0000646)3.73976070
25Hepatocellular carcinoma (HP:0001402)3.35709164
26Horizontal nystagmus (HP:0000666)3.18548386
27Melanoma (HP:0002861)2.78317565
28* Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.75909939
29Degeneration of anterior horn cells (HP:0002398)2.53203334
30Abnormality of the anterior horn cell (HP:0006802)2.53203334
31Peripheral hypomyelination (HP:0007182)2.50301118
32Abnormality of liposaccharide metabolism (HP:0010968)2.50240908
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.50240908
34Abnormality of glycolipid metabolism (HP:0010969)2.50240908
35Asymmetric septal hypertrophy (HP:0001670)2.47336282
36Abnormality of vision evoked potentials (HP:0000649)2.41115245
37Abnormal auditory evoked potentials (HP:0006958)2.37154564
38Abnormal gallbladder physiology (HP:0012438)2.23943291
39Cholecystitis (HP:0001082)2.23943291
40Tongue fasciculations (HP:0001308)2.20313652
41Frequent falls (HP:0002359)2.16438691
42Scapular winging (HP:0003691)2.13358619
43Spastic diplegia (HP:0001264)2.12280355
44Urinary glycosaminoglycan excretion (HP:0003541)2.12192424
45Mucopolysacchariduria (HP:0008155)2.12192424
46Rhabdomyosarcoma (HP:0002859)2.11601043
47Renal cell carcinoma (HP:0005584)2.10332000
48Hypokinesia (HP:0002375)2.07963603
49Facial cleft (HP:0002006)2.07211825
50Aplasia/Hypoplasia of the fovea (HP:0008060)12.7895374
51Hypoplasia of the fovea (HP:0007750)12.7895374
52Abnormality of the fovea (HP:0000493)10.6003144
53Cerebral inclusion bodies (HP:0100314)1.94158703
54Synophrys (HP:0000664)1.91483330
55Abnormality of polysaccharide metabolism (HP:0011012)1.90690071
56Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90690071
57Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90690071
58Muscle fibrillation (HP:0010546)1.88018680
59Underdeveloped nasal alae (HP:0000430)1.85787939
60Cerebral hypomyelination (HP:0006808)1.84365874
61Visual hallucinations (HP:0002367)1.83822073
62Hypermelanotic macule (HP:0001034)1.82579265
63Fibular hypoplasia (HP:0003038)1.80895854
64Astigmatism (HP:0000483)1.80421242
65Hepatitis (HP:0012115)1.79265963
66Melanocytic nevus (HP:0000995)1.76855287
67Vertebral compression fractures (HP:0002953)1.73075030
68Loss of speech (HP:0002371)1.69221593
69Dysostosis multiplex (HP:0000943)1.68310698
70Abnormal autonomic nervous system physiology (HP:0012332)1.67797946
71Tented upper lip vermilion (HP:0010804)1.64075423
72Epidermoid cyst (HP:0200040)1.63448211
73Adrenal hypoplasia (HP:0000835)1.61523673
74Abnormality of glycolysis (HP:0004366)1.59242532
75Aplasia cutis congenita (HP:0001057)1.58291101
76Morphological abnormality of the inner ear (HP:0011390)1.56990280
77Alacrima (HP:0000522)1.55672702
78Conjunctival hamartoma (HP:0100780)1.55292176
79Abnormality of the anterior chamber (HP:0000593)1.51787061
80Abnormality of the pupil (HP:0000615)1.47764716
81Exercise-induced muscle cramps (HP:0003710)1.46838460
82Hamartoma of the eye (HP:0010568)1.45626221
83Hand muscle atrophy (HP:0009130)1.44208245
84Hypoplasia of the capital femoral epiphysis (HP:0003090)1.43748793
85Neoplasm of the liver (HP:0002896)1.43648972
86Neoplasm of striated muscle (HP:0009728)1.43396407
87Supernumerary ribs (HP:0005815)1.42764780
88Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.42655045
89Absent epiphyses (HP:0010577)1.42655045
90Narrow nasal bridge (HP:0000446)1.42017522
91Myelomeningocele (HP:0002475)1.41709383
92J-shaped sella turcica (HP:0002680)1.41170546
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.41076251
94Poor head control (HP:0002421)1.40668042
95Dyschromatopsia (HP:0007641)1.40612023
96Lip pit (HP:0100267)1.40194166
97Impaired proprioception (HP:0010831)1.38457325
98Large for gestational age (HP:0001520)1.38338423
99Diminished movement (HP:0002374)1.37271260
100Spastic paraplegia (HP:0001258)1.35852595
101Long toe (HP:0010511)1.35811640
102Cerebral aneurysm (HP:0004944)1.35605412
103Increased cerebral lipofuscin (HP:0011813)1.34927485
104Decreased lacrimation (HP:0000633)1.31139319
105Ulnar deviation of finger (HP:0009465)1.29907795
106Skin nodule (HP:0200036)1.26728171
107Megalencephaly (HP:0001355)1.26231898
108Akinesia (HP:0002304)1.25228408
109Tracheomalacia (HP:0002779)1.23956457
110Spinal muscular atrophy (HP:0007269)1.23438944
111Supernumerary bones of the axial skeleton (HP:0009144)1.21927809
112Overlapping toe (HP:0001845)1.21855676
113Intestinal atresia (HP:0011100)1.20793459
114Synostosis of carpal bones (HP:0005048)1.20019669
115Hypermetropia (HP:0000540)1.19399901
116Paraparesis (HP:0002385)1.19318145
117Paraplegia (HP:0010550)1.19299012
118Abnormal pupillary function (HP:0007686)1.18743301
119Morphological abnormality of the middle ear (HP:0008609)1.18354615
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.18288944
121Abnormality of the nasal septum (HP:0000419)1.17731589
122Distal upper limb amyotrophy (HP:0007149)1.17279494
123Upper limb amyotrophy (HP:0009129)1.17279494
124Delusions (HP:0000746)1.16254769
125Leukodystrophy (HP:0002415)1.15613457
126Atelectasis (HP:0100750)1.15495254
127* Photophobia (HP:0000613)1.15237894
128Aortic aneurysm (HP:0004942)1.14377492
129Asymmetry of the thorax (HP:0001555)1.13932138
130Coarse hair (HP:0002208)1.12264693
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.11172219
132Esophageal neoplasm (HP:0100751)1.10709003
133Neoplasm of head and neck (HP:0012288)1.10709003
134Long clavicles (HP:0000890)1.10552107
135Aplasia/Hypoplasia of the fibula (HP:0006492)1.09694072
136Prolonged neonatal jaundice (HP:0006579)1.08886763
137Abnormality of the shoulder girdle musculature (HP:0001435)1.08790256
138Spastic paraparesis (HP:0002313)1.08519278
139Vascular tortuosity (HP:0004948)1.06831472
140Proximal amyotrophy (HP:0007126)1.06665192
141Fatigue (HP:0012378)1.06556415
142Carpal synostosis (HP:0009702)1.06390598
143Distal sensory impairment (HP:0002936)1.06018628
144Subaortic stenosis (HP:0001682)1.05152763
145Premature rupture of membranes (HP:0001788)1.03289839
146Hypopigmented skin patches (HP:0001053)1.01958513
147Upper limb muscle weakness (HP:0003484)1.01562163
148Ovoid vertebral bodies (HP:0003300)1.01525864
149Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.00615847
150Deep venous thrombosis (HP:0002625)1.00263038
151Exostoses (HP:0100777)0.99869531
152Bladder diverticulum (HP:0000015)0.97432914
153Cutaneous finger syndactyly (HP:0010554)0.96118810
154Bladder neoplasm (HP:0009725)0.95573552
155Bladder carcinoma (HP:0002862)0.95573552
156Spontaneous hematomas (HP:0007420)0.93536247
157Acrocyanosis (HP:0001063)0.93147425
158Abnormality of proline metabolism (HP:0010907)0.93119270
159Hydroxyprolinuria (HP:0003080)0.93119270
160Abnormality of the antihelix (HP:0009738)0.91550726
161Decreased motor nerve conduction velocity (HP:0003431)0.91282544
162Leiomyosarcoma (HP:0100243)0.90778673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET5.69369584
2PDK24.91808246
3MARK34.00256675
4BMX3.98370399
5PKN23.67439233
6EIF2AK13.14157506
7WEE13.07536034
8PRKCH2.84827277
9TRIB32.53421318
10MAP3K32.32119175
11BMPR1B2.29527274
12SIK32.18014845
13EPHA32.10843515
14MST1R13.3476337
15PTK2B1.73086748
16ERBB31.71275639
17BMPR21.65706895
18GRK61.59395433
19SCYL21.57921475
20GRK51.41594802
21EIF2AK31.41287217
22PRKD31.39334685
23TRIM281.38620257
24ACVR1B1.35940407
25NME21.32660544
26MAPKAPK31.19772075
27PLK31.15585676
28CDK31.14929417
29DDR21.10726941
30LATS11.01275819
31PRKD11.00193824
32FLT30.93193736
33NEK60.90440450
34ICK0.88439444
35PTK60.84213739
36TGFBR20.82163798
37BRSK10.81726809
38SIK20.81083725
39NEK10.79741817
40GSK3A0.78405641
41TTN0.77813849
42LRRK20.71561055
43ABL20.71276548
44CAMKK10.67046391
45MATK0.63666384
46ATR0.63269657
47KIT0.63031060
48LIMK10.62973309
49CSNK1G10.61822470
50KSR20.57105557
51CSNK1G30.56742544
52RET0.55633655
53MAP3K20.54584514
54CSNK1A1L0.53785366
55ADRBK10.53198153
56DYRK1A0.53101132
57PLK10.52870138
58KSR10.51847661
59PAK40.46663460
60RPS6KB20.44669410
61FER0.43493160
62CSNK1G20.42628250
63ILK0.40625714
64EGFR0.39774306
65TGFBR10.38905906
66ERBB20.38744212
67FGFR40.38585575
68CAMKK20.38534864
69MAP4K20.38424852
70STK380.37826434
71MAP3K130.37100033
72PDGFRA0.36692683
73PRKG20.36133933
74TSSK60.35922147
75BRD40.35840213
76MAP3K90.35536712
77TBK10.35435079
78RIPK10.35174455
79ERBB40.34958581
80EEF2K0.33017985
81MAPK100.32909816
82AKT20.32229572
83CSNK1A10.31606381
84ATM0.31474150
85PAK60.30974445
86CLK10.30496860
87CDK70.29229636
88ZAP700.29108973
89PRKCE0.27928320
90CDK180.26836113
91PRKCG0.26564758
92TYK20.25993281
93PRKCZ0.25954162
94LMTK20.25900238
95INSR0.25767028
96MAP2K10.25645220
97CDK60.25457717
98CCNB10.23269121
99CAMK2A0.23251551
100RAF10.22884139
101KDR0.22572525
102DMPK0.22152314
103MAP3K80.21464990
104BCKDK0.21341183
105MAP3K110.20935299
106CDC70.20803843
107FRK0.20616654
108CDK11A0.19601425
109CDK150.17881021
110FGFR30.17779941
111TLK10.16927736
112FGR0.16671791
113SIK10.16605375
114ALK0.16306396
115STK40.15782333
116CHEK20.15297585
117CSNK2A10.15283375
118CAMK1D0.15008283
119NTRK10.14993023
120LATS20.14469291
121SGK30.13704508
122RPS6KA10.13568541
123TTK0.13253802
124TYRO30.13164465
125ARAF0.12167864
126MAPK120.12127857
127IGF1R0.12062259
128CDK40.11403430
129ABL10.11286249
130SGK20.11181672
131PLK20.10744437
132FGFR10.10272970
133STK30.10173784
134BRSK20.10160664
135SRC0.09534857
136PAK30.09239882
137BLK0.09081689
138MAPK30.09057122
139PDGFRB0.08703847
140PAK20.08655222
141CSNK1D0.07873174
142NEK20.07360043
143PTK20.06845712
144MAP4K10.06413460
145PRKACB0.06374932
146PRKAA20.06242304
147EPHB10.05972959
148DYRK1B0.05825056
149MOS0.05488688
150ZAK0.05232138
151TRPM70.04812155
152FGFR20.04043760
153AKT10.02998163
154MAPK110.02807559
155MAP2K60.02367482
156PDK10.02361905
157LYN0.02241039
158NEK90.02221805
159WNK40.01962609
160PRKCQ0.01918867
161NUAK10.01671103

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.12373566
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.03074753
3Melanogenesis_Homo sapiens_hsa049163.95102755
4Non-homologous end-joining_Homo sapiens_hsa034503.65021781
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.32635603
6Central carbon metabolism in cancer_Homo sapiens_hsa052302.76377584
7Proteasome_Homo sapiens_hsa030502.50751192
8Galactose metabolism_Homo sapiens_hsa000522.43124969
9Other glycan degradation_Homo sapiens_hsa005112.39558373
10Oxidative phosphorylation_Homo sapiens_hsa001902.28148725
11Protein export_Homo sapiens_hsa030602.23661090
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.16267583
13Homologous recombination_Homo sapiens_hsa034402.10640467
14Melanoma_Homo sapiens_hsa052182.07589923
15Parkinsons disease_Homo sapiens_hsa050122.05317787
16Renal cell carcinoma_Homo sapiens_hsa052112.01833431
17Tyrosine metabolism_Homo sapiens_hsa0035010.2401160
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92715757
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88327997
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.84408042
21Sphingolipid metabolism_Homo sapiens_hsa006001.81644220
22Fatty acid elongation_Homo sapiens_hsa000621.76322496
23Glutathione metabolism_Homo sapiens_hsa004801.73949044
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.69404774
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68910692
26Starch and sucrose metabolism_Homo sapiens_hsa005001.52523118
27Biosynthesis of amino acids_Homo sapiens_hsa012301.51903455
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51583058
29Adherens junction_Homo sapiens_hsa045201.45704033
30Alzheimers disease_Homo sapiens_hsa050101.44993188
31Fructose and mannose metabolism_Homo sapiens_hsa000511.43969010
32Systemic lupus erythematosus_Homo sapiens_hsa053221.34726876
33One carbon pool by folate_Homo sapiens_hsa006701.32863731
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31729009
35Huntingtons disease_Homo sapiens_hsa050161.22805265
36Malaria_Homo sapiens_hsa051441.18150601
37Pentose phosphate pathway_Homo sapiens_hsa000301.12932327
38Carbon metabolism_Homo sapiens_hsa012001.10762330
39N-Glycan biosynthesis_Homo sapiens_hsa005101.06577091
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06557055
41Mismatch repair_Homo sapiens_hsa034301.06232679
42HIF-1 signaling pathway_Homo sapiens_hsa040661.04100071
43Vibrio cholerae infection_Homo sapiens_hsa051101.03263719
44Pyruvate metabolism_Homo sapiens_hsa006201.00679930
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99628841
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95290974
47Collecting duct acid secretion_Homo sapiens_hsa049660.94173003
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93904216
49Lysosome_Homo sapiens_hsa041420.90831814
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89957476
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89835417
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89557162
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89075129
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88146706
55MicroRNAs in cancer_Homo sapiens_hsa052060.85164513
56p53 signaling pathway_Homo sapiens_hsa041150.82179376
57Fanconi anemia pathway_Homo sapiens_hsa034600.80956609
58Proteoglycans in cancer_Homo sapiens_hsa052050.76643874
59Alcoholism_Homo sapiens_hsa050340.76556663
60Cell cycle_Homo sapiens_hsa041100.76402510
61Glioma_Homo sapiens_hsa052140.73251161
62Focal adhesion_Homo sapiens_hsa045100.71042800
63Chemical carcinogenesis_Homo sapiens_hsa052040.70109239
64Small cell lung cancer_Homo sapiens_hsa052220.69958633
65Axon guidance_Homo sapiens_hsa043600.69761683
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69267502
67Chronic myeloid leukemia_Homo sapiens_hsa052200.68865190
68Folate biosynthesis_Homo sapiens_hsa007900.68536982
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67861577
70Butanoate metabolism_Homo sapiens_hsa006500.66540079
71mTOR signaling pathway_Homo sapiens_hsa041500.66218753
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63857965
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63722033
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63279797
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62438775
76Viral carcinogenesis_Homo sapiens_hsa052030.62163948
77Basal transcription factors_Homo sapiens_hsa030220.59769585
78Histidine metabolism_Homo sapiens_hsa003400.56967059
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.56278887
80Estrogen signaling pathway_Homo sapiens_hsa049150.54139569
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53975447
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53957336
83RNA transport_Homo sapiens_hsa030130.53069920
84ABC transporters_Homo sapiens_hsa020100.50605150
85Bile secretion_Homo sapiens_hsa049760.50124734
86beta-Alanine metabolism_Homo sapiens_hsa004100.49939939
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.48165661
88Base excision repair_Homo sapiens_hsa034100.47169594
89Steroid biosynthesis_Homo sapiens_hsa001000.46393771
90VEGF signaling pathway_Homo sapiens_hsa043700.46086463
91Prostate cancer_Homo sapiens_hsa052150.45993156
92Prolactin signaling pathway_Homo sapiens_hsa049170.45641879
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.45546352
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45387970
95DNA replication_Homo sapiens_hsa030300.44447234
96Thyroid cancer_Homo sapiens_hsa052160.43922850
97Nucleotide excision repair_Homo sapiens_hsa034200.43748942
98Osteoclast differentiation_Homo sapiens_hsa043800.43672847
99Glucagon signaling pathway_Homo sapiens_hsa049220.43194352
100Endometrial cancer_Homo sapiens_hsa052130.42498711
101Insulin signaling pathway_Homo sapiens_hsa049100.42048946
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41825128
103Inositol phosphate metabolism_Homo sapiens_hsa005620.41440666
104Vitamin B6 metabolism_Homo sapiens_hsa007500.41151396
105ErbB signaling pathway_Homo sapiens_hsa040120.40999717
106Lysine degradation_Homo sapiens_hsa003100.39360379
107Rap1 signaling pathway_Homo sapiens_hsa040150.38036256
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37858633
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35662354
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34894780
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34890589
112Fat digestion and absorption_Homo sapiens_hsa049750.34783118
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34129500
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33980427
115Phenylalanine metabolism_Homo sapiens_hsa003600.33822941
116Fatty acid degradation_Homo sapiens_hsa000710.33785122
117RNA polymerase_Homo sapiens_hsa030200.33098237
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.32444267
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30777093
120RNA degradation_Homo sapiens_hsa030180.30447680
121Ras signaling pathway_Homo sapiens_hsa040140.30371768
122Arginine biosynthesis_Homo sapiens_hsa002200.29986629
123Pyrimidine metabolism_Homo sapiens_hsa002400.29435631
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.26434940
125Nitrogen metabolism_Homo sapiens_hsa009100.26420819
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25130634
127Fatty acid metabolism_Homo sapiens_hsa012120.24843358
128Synaptic vesicle cycle_Homo sapiens_hsa047210.24832424
129Phagosome_Homo sapiens_hsa041450.24406551
130Hepatitis B_Homo sapiens_hsa051610.24126924
131Peroxisome_Homo sapiens_hsa041460.23120469
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22062445
133Sulfur metabolism_Homo sapiens_hsa009200.21838173
134Insulin resistance_Homo sapiens_hsa049310.21398625
135Selenocompound metabolism_Homo sapiens_hsa004500.21070683
136Endocytosis_Homo sapiens_hsa041440.21017219
137Arginine and proline metabolism_Homo sapiens_hsa003300.20688733
138AMPK signaling pathway_Homo sapiens_hsa041520.20552267
139Non-small cell lung cancer_Homo sapiens_hsa052230.20426017
140Propanoate metabolism_Homo sapiens_hsa006400.20330408
141Linoleic acid metabolism_Homo sapiens_hsa005910.20243602
142Metabolic pathways_Homo sapiens_hsa011000.19167042
143Oocyte meiosis_Homo sapiens_hsa041140.18704187
144Pathways in cancer_Homo sapiens_hsa052000.18597715
145Tight junction_Homo sapiens_hsa045300.18044122
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17772262
147Colorectal cancer_Homo sapiens_hsa052100.17593236
148Fatty acid biosynthesis_Homo sapiens_hsa000610.16683245
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.16159902
150Thyroid hormone synthesis_Homo sapiens_hsa049180.16126935
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13034467
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12339138
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10671263
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09390521
155FoxO signaling pathway_Homo sapiens_hsa040680.08289964
156Mineral absorption_Homo sapiens_hsa049780.07666671

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