SLC43A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.69606880
2protoporphyrinogen IX biosynthetic process (GO:0006782)8.31906796
3heme biosynthetic process (GO:0006783)6.77077272
4negative regulation of fibrinolysis (GO:0051918)6.74936092
5regulation of fibrinolysis (GO:0051917)6.59894000
6porphyrin-containing compound biosynthetic process (GO:0006779)6.31090017
7regulation of protein activation cascade (GO:2000257)6.13602161
8protein carboxylation (GO:0018214)6.06511890
9peptidyl-glutamic acid carboxylation (GO:0017187)6.06511890
10complement activation, alternative pathway (GO:0006957)6.00800182
11L-phenylalanine catabolic process (GO:0006559)5.83064931
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.83064931
13regulation of complement activation (GO:0030449)5.81135795
14glyoxylate metabolic process (GO:0046487)5.69096047
15tetrapyrrole biosynthetic process (GO:0033014)5.65224769
16L-phenylalanine metabolic process (GO:0006558)5.54342894
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.54342894
18heme metabolic process (GO:0042168)5.42954180
19ribosomal small subunit assembly (GO:0000028)5.36804657
20DNA strand elongation involved in DNA replication (GO:0006271)5.28048364
21telomere maintenance via semi-conservative replication (GO:0032201)5.18355565
22urea metabolic process (GO:0019627)5.11263379
23porphyrin-containing compound metabolic process (GO:0006778)5.10454753
24DNA strand elongation (GO:0022616)5.05673228
25blood coagulation, intrinsic pathway (GO:0007597)5.00181701
26DNA replication initiation (GO:0006270)4.96038272
27regulation of plasminogen activation (GO:0010755)4.87533495
28erythrocyte maturation (GO:0043249)4.86955611
29urea cycle (GO:0000050)4.82599041
30very-low-density lipoprotein particle assembly (GO:0034379)4.81965466
31negative regulation of sterol transport (GO:0032372)4.75975290
32negative regulation of cholesterol transport (GO:0032375)4.75975290
33intestinal cholesterol absorption (GO:0030299)4.75262456
34DNA unwinding involved in DNA replication (GO:0006268)4.74757037
35regulation of cholesterol esterification (GO:0010872)4.70990036
36fibrinolysis (GO:0042730)4.65216981
37proline metabolic process (GO:0006560)4.64810609
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.64301596
39nitrogen cycle metabolic process (GO:0071941)4.61223175
40glycine metabolic process (GO:0006544)4.54313749
41plasma lipoprotein particle assembly (GO:0034377)4.49505025
42viral transcription (GO:0019083)4.47772889
43plasma lipoprotein particle remodeling (GO:0034369)4.42045218
44protein-lipid complex remodeling (GO:0034368)4.42045218
45macromolecular complex remodeling (GO:0034367)4.42045218
46telomere maintenance via recombination (GO:0000722)4.41271826
47regulation of triglyceride catabolic process (GO:0010896)4.40624881
48translational termination (GO:0006415)4.33825047
49epoxygenase P450 pathway (GO:0019373)4.28243629
50phospholipid efflux (GO:0033700)4.24942192
51cholesterol efflux (GO:0033344)4.16874686
52serine family amino acid catabolic process (GO:0009071)4.09669943
53drug catabolic process (GO:0042737)4.09376286
54mitotic recombination (GO:0006312)4.08585814
55acute-phase response (GO:0006953)4.07545735
56protein-lipid complex assembly (GO:0065005)4.07514178
57DNA replication checkpoint (GO:0000076)4.06608577
58positive regulation of triglyceride lipase activity (GO:0061365)4.06200121
59positive regulation of lipoprotein lipase activity (GO:0051006)4.06200121
60serine family amino acid biosynthetic process (GO:0009070)4.04558903
61DNA deamination (GO:0045006)4.00952516
62translational elongation (GO:0006414)3.97525767
63proline biosynthetic process (GO:0006561)3.96698823
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94499497
65high-density lipoprotein particle remodeling (GO:0034375)3.93559783
66imidazole-containing compound metabolic process (GO:0052803)3.92464051
67cytolysis (GO:0019835)3.89841675
68plasma lipoprotein particle organization (GO:0071827)3.86919138
69low-density lipoprotein particle remodeling (GO:0034374)3.86012506
70regulation of cholesterol homeostasis (GO:2000188)3.82576793
71exogenous drug catabolic process (GO:0042738)3.82541550
72positive regulation of fatty acid biosynthetic process (GO:0045723)3.82133609
73oxaloacetate metabolic process (GO:0006107)3.77418450
74plasma lipoprotein particle clearance (GO:0034381)3.74805790
75telomere maintenance via telomere lengthening (GO:0010833)3.72686773
76protein activation cascade (GO:0072376)3.72580985
77folic acid-containing compound biosynthetic process (GO:0009396)3.72398448
78CENP-A containing nucleosome assembly (GO:0034080)3.70459289
79L-serine metabolic process (GO:0006563)3.69945993
80negative regulation of fatty acid biosynthetic process (GO:0045717)3.69671256
81omega-hydroxylase P450 pathway (GO:0097267)3.69601829
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69033038
83protein-lipid complex subunit organization (GO:0071825)3.67808124
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67611706
85protein localization to kinetochore (GO:0034501)3.66823366
86IMP biosynthetic process (GO:0006188)3.66116288
87positive regulation of hemostasis (GO:1900048)3.65149626
88positive regulation of blood coagulation (GO:0030194)3.65149626
89serine family amino acid metabolic process (GO:0009069)3.63973445
90triglyceride homeostasis (GO:0070328)3.63508573
91acylglycerol homeostasis (GO:0055090)3.63508573
92regulation of apoptotic cell clearance (GO:2000425)3.62432873
93maturation of SSU-rRNA (GO:0030490)3.60403113
94nucleotide-excision repair, DNA gap filling (GO:0006297)3.60237220
95ethanol oxidation (GO:0006069)3.60224692
96negative regulation of hemostasis (GO:1900047)3.59262416
97negative regulation of blood coagulation (GO:0030195)3.59262416
98regulation of humoral immune response (GO:0002920)3.58478191
99cotranslational protein targeting to membrane (GO:0006613)3.57446663
100protein targeting to ER (GO:0045047)3.57122482
101erythrocyte development (GO:0048821)3.53320087
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52693022
103DNA replication-dependent nucleosome assembly (GO:0006335)3.50876058
104DNA replication-dependent nucleosome organization (GO:0034723)3.50876058
105chromatin remodeling at centromere (GO:0031055)3.50823492
106ribosomal small subunit biogenesis (GO:0042274)3.50058985
107protein localization to chromosome, centromeric region (GO:0071459)3.49690314
108kinetochore organization (GO:0051383)3.47265313
109regulation of bile acid biosynthetic process (GO:0070857)3.46425278
110translational initiation (GO:0006413)3.46054660
111pigment biosynthetic process (GO:0046148)3.45131806
112complement activation, classical pathway (GO:0006958)3.43679888
113reverse cholesterol transport (GO:0043691)3.41009955
114negative regulation of protein activation cascade (GO:2000258)3.39810575
115establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39594044
116glutamate metabolic process (GO:0006536)3.39138245
117DNA replication-independent nucleosome assembly (GO:0006336)3.38991181
118DNA replication-independent nucleosome organization (GO:0034724)3.38991181
119protein localization to endoplasmic reticulum (GO:0070972)3.36719060
120regulation of lipoprotein particle clearance (GO:0010984)3.35942127
121cellular protein complex disassembly (GO:0043624)3.34544867
122aromatic amino acid family catabolic process (GO:0009074)3.34437740
123tetrapyrrole metabolic process (GO:0033013)3.32943174
124complement activation (GO:0006956)3.32328776
125positive regulation of coagulation (GO:0050820)3.29275553
126regulation of fatty acid biosynthetic process (GO:0042304)3.26639445
127viral life cycle (GO:0019058)3.25474618
128IMP metabolic process (GO:0046040)3.24706292
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23491338
130formation of translation preinitiation complex (GO:0001731)3.21100682
131negative regulation of coagulation (GO:0050819)3.20413735
132attachment of spindle microtubules to kinetochore (GO:0008608)3.19267063
133meiotic chromosome segregation (GO:0045132)3.18144534
134bile acid biosynthetic process (GO:0006699)3.17946965
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.17885971
136drug metabolic process (GO:0017144)3.17127248
137cysteine metabolic process (GO:0006534)3.13578648
138tyrosine metabolic process (GO:0006570)3.12306257
139bile acid metabolic process (GO:0008206)3.12236668
140cellular glucuronidation (GO:0052695)3.12059493
141tetrahydrofolate metabolic process (GO:0046653)3.09851962
142protein complex disassembly (GO:0043241)3.08724231
143phenylpropanoid metabolic process (GO:0009698)3.07489543
144mitotic sister chromatid segregation (GO:0000070)3.06370740
145negative regulation of wound healing (GO:0061045)3.06314372
146mitotic nuclear envelope disassembly (GO:0007077)3.04244953
147kinetochore assembly (GO:0051382)3.03446689
148uronic acid metabolic process (GO:0006063)3.02418701
149glucuronate metabolic process (GO:0019585)3.02418701
150regulation of immune response to tumor cell (GO:0002837)2.99827905
151regulation of response to tumor cell (GO:0002834)2.99827905
152positive regulation of response to tumor cell (GO:0002836)2.99827905
153positive regulation of immune response to tumor cell (GO:0002839)2.99827905
154acute inflammatory response (GO:0002526)2.98189095
155negative regulation of lipase activity (GO:0060192)2.97666535
156negative regulation of RNA splicing (GO:0033119)2.96729943
157nucleobase biosynthetic process (GO:0046112)2.96592661
158ethanol metabolic process (GO:0006067)2.95687253
159hemoglobin metabolic process (GO:0020027)2.94599963
160regulation of histone H3-K9 methylation (GO:0051570)2.93677615
161pigment metabolic process (GO:0042440)2.92542595
162macromolecular complex disassembly (GO:0032984)2.88121878
163translesion synthesis (GO:0019985)2.86787923
164purine-containing compound salvage (GO:0043101)2.86479387
165telomere maintenance (GO:0000723)2.85674299
166chromatin assembly or disassembly (GO:0006333)2.85605333
167sister chromatid segregation (GO:0000819)2.85579585
168negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85525894
169definitive hemopoiesis (GO:0060216)2.85462554
170mitotic chromosome condensation (GO:0007076)2.85345655
171telomere organization (GO:0032200)2.85307752
172nuclear-transcribed mRNA catabolic process (GO:0000956)2.83129856
173histone exchange (GO:0043486)2.81533776
174pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.80231726
175erythrocyte differentiation (GO:0030218)2.79963075
176ribosomal large subunit biogenesis (GO:0042273)2.79685871
177deoxyribonucleotide biosynthetic process (GO:0009263)2.78732618
178DNA duplex unwinding (GO:0032508)2.76934900
179membrane disassembly (GO:0030397)2.76278058
180nuclear envelope disassembly (GO:0051081)2.76278058
181DNA geometric change (GO:0032392)2.74260429
182DNA topological change (GO:0006265)2.70558048
183RNA catabolic process (GO:0006401)2.69164276
184mRNA catabolic process (GO:0006402)2.68142417
185response to lead ion (GO:0010288)2.65981482
186pteridine-containing compound biosynthetic process (GO:0042559)2.65939968
187ribonucleoprotein complex biogenesis (GO:0022613)2.65921189
188pseudouridine synthesis (GO:0001522)2.64701656
189translation (GO:0006412)2.62690276
190protein autoprocessing (GO:0016540)2.61916858
191pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.59550800
192one-carbon compound transport (GO:0019755)2.56492328
193purine nucleobase biosynthetic process (GO:0009113)2.56137298
1943-UTR-mediated mRNA stabilization (GO:0070935)2.55940284
195mitotic metaphase plate congression (GO:0007080)2.54908537
196maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53463813
197cell cycle G1/S phase transition (GO:0044843)2.51147652
198G1/S transition of mitotic cell cycle (GO:0000082)2.51147652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22170111
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.80386303
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.69753210
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53679204
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.50090042
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.44542095
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88298857
8GATA1_22025678_ChIP-Seq_K562_Human2.50076184
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44484474
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33984048
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.31735150
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.30952984
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27724657
14SCL_19346495_ChIP-Seq_HPC-7_Human2.25891214
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19642394
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16433356
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.14290035
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06688250
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06613374
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06107563
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05534522
22* MYC_22102868_ChIP-Seq_BL_Human2.00881786
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.00022458
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.99690480
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99076360
26XRN2_22483619_ChIP-Seq_HELA_Human1.95791954
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95347250
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94218510
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92795808
30AR_21909140_ChIP-Seq_LNCAP_Human1.92156064
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86888930
32VDR_23849224_ChIP-Seq_CD4+_Human1.86795951
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.82645567
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78633103
35FOXP3_21729870_ChIP-Seq_TREG_Human1.77890764
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73966664
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68531049
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67628499
39VDR_21846776_ChIP-Seq_THP-1_Human1.65931041
40* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.61617929
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61116253
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60237631
43ZNF263_19887448_ChIP-Seq_K562_Human1.59773153
44DCP1A_22483619_ChIP-Seq_HELA_Human1.58992733
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58009448
46CIITA_25753668_ChIP-Seq_RAJI_Human1.57578405
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56555951
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56521466
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56042221
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.54901733
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53408721
52LXR_22292898_ChIP-Seq_THP-1_Human1.52518506
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52094895
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.49913676
55GABP_19822575_ChIP-Seq_HepG2_Human1.49668191
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45669855
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44108552
58* GATA1_19941827_ChIP-Seq_MEL_Mouse1.43305768
59TTF2_22483619_ChIP-Seq_HELA_Human1.42167834
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40201568
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39447034
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37620361
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35029614
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35026561
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33983757
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33154086
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32361677
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31042521
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30022603
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29864310
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28866023
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.28192360
73* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27464800
74GATA1_19941826_ChIP-Seq_K562_Human1.27144841
75ELK1_19687146_ChIP-ChIP_HELA_Human1.25420824
76* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25374317
77* ELK3_25401928_ChIP-Seq_HUVEC_Human1.24384289
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22370625
79KDM5A_27292631_Chip-Seq_BREAST_Human1.20743794
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.20713611
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20582144
82* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19487037
83NCOR1_26117541_ChIP-Seq_K562_Human1.19163966
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17790790
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17284945
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14537359
87* HNF4A_19822575_ChIP-Seq_HepG2_Human1.14470628
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14164833
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11353305
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11231092
91* TCF7_22412390_ChIP-Seq_EML_Mouse1.09856446
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08996136
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08687297
94P68_20966046_ChIP-Seq_HELA_Human1.08151430
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.07597579
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.07043615
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06482719
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06009639
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05257861
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04827909
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04567248
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03865406
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03745315
104* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03586476
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03467372
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03209391
107* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03044770
108VDR_24763502_ChIP-Seq_THP-1_Human1.02357076
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02293143
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01258779
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00937676
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00922893
113BCOR_27268052_Chip-Seq_Bcells_Human1.00371598
114RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99639671
115* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99566327
116TFEB_21752829_ChIP-Seq_HELA_Human0.98319973
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98087663
118MAF_26560356_Chip-Seq_TH1_Human0.96653894
119* SPI1_23547873_ChIP-Seq_NB4_Human0.96436288
120* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95616926
121RACK7_27058665_Chip-Seq_MCF-7_Human0.94940482
122* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93565675
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93275980
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93153941
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92992336
126TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92508807
127UTX_26944678_Chip-Seq_JUKART_Human0.92213176
128MYB_26560356_Chip-Seq_TH1_Human0.91078847
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.90758460
130MAF_26560356_Chip-Seq_TH2_Human0.90381155
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90166636
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89211155
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87987537
134PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85397074
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85256248
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83034295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.45077257
2MP0004147_increased_porphyrin_level6.16432850
3MP0010094_abnormal_chromosome_stability3.72858938
4MP0001666_abnormal_nutrient_absorption3.47988637
5MP0003693_abnormal_embryo_hatching3.44008348
6MP0003111_abnormal_nucleus_morphology3.40805019
7MP0002396_abnormal_hematopoietic_system3.18791350
8MP0008057_abnormal_DNA_replication3.04877092
9MP0003195_calcinosis2.95516537
10MP0008875_abnormal_xenobiotic_pharmacok2.95488897
11MP0003077_abnormal_cell_cycle2.88544135
12MP0003868_abnormal_feces_composition2.85825774
13MP0001545_abnormal_hematopoietic_system2.81043861
14MP0005397_hematopoietic_system_phenotyp2.81043861
15MP0002138_abnormal_hepatobiliary_system2.77386106
16MP0005670_abnormal_white_adipose2.76197820
17MP0005451_abnormal_body_composition2.70731151
18MP0004957_abnormal_blastocyst_morpholog2.70663191
19MP0006054_spinal_hemorrhage2.68889858
20MP0009840_abnormal_foam_cell2.36210419
21MP0008058_abnormal_DNA_repair2.34949323
22MP0003806_abnormal_nucleotide_metabolis2.26546835
23MP0003252_abnormal_bile_duct2.16566123
24MP0004808_abnormal_hematopoietic_stem1.94621558
25MP0005332_abnormal_amino_acid1.91533675
26MP0000490_abnormal_crypts_of1.88112042
27MP0008007_abnormal_cellular_replicative1.83813552
28MP0006036_abnormal_mitochondrial_physio1.74851238
29MP0005058_abnormal_lysosome_morphology1.73616164
30MP0005083_abnormal_biliary_tract1.72776591
31MP0002139_abnormal_hepatobiliary_system1.68873094
32MP0002398_abnormal_bone_marrow1.68007130
33MP0003172_abnormal_lysosome_physiology1.63691486
34MP0001661_extended_life_span1.61732405
35MP0003186_abnormal_redox_activity1.59647961
36MP0000685_abnormal_immune_system1.53348225
37MP0002722_abnormal_immune_system1.52832846
38MP0000689_abnormal_spleen_morphology1.52782815
39MP0002118_abnormal_lipid_homeostasis1.46615671
40MP0009333_abnormal_splenocyte_physiolog1.43648109
41MP0008932_abnormal_embryonic_tissue1.43511463
42MP0000350_abnormal_cell_proliferation1.42688646
43MP0002132_abnormal_respiratory_system1.40920144
44MP0005076_abnormal_cell_differentiation1.40648050
45MP0010307_abnormal_tumor_latency1.38008441
46MP0002019_abnormal_tumor_incidence1.37068134
47MP0003763_abnormal_thymus_physiology1.36760305
48MP0003183_abnormal_peptide_metabolism1.31408802
49MP0002429_abnormal_blood_cell1.30261551
50MP0001730_embryonic_growth_arrest1.29704466
51MP0000703_abnormal_thymus_morphology1.29525120
52MP0005464_abnormal_platelet_physiology1.28139030
53MP0000313_abnormal_cell_death1.23182019
54MP0005636_abnormal_mineral_homeostasis1.21259546
55MP0005220_abnormal_exocrine_pancreas1.20879968
56MP0005085_abnormal_gallbladder_physiolo1.15787353
57MP0010352_gastrointestinal_tract_polyps1.13742089
58MP0005365_abnormal_bile_salt1.11332576
59MP0003436_decreased_susceptibility_to1.10281846
60MP0009278_abnormal_bone_marrow1.08423963
61MP0002080_prenatal_lethality1.07301097
62MP0002166_altered_tumor_susceptibility1.06055347
63MP0005666_abnormal_adipose_tissue1.04013041
64MP0005671_abnormal_response_to1.03966990
65MP0003567_abnormal_fetal_cardiomyocyte1.03242108
66MP0005408_hypopigmentation0.99978283
67MP0001853_heart_inflammation0.99786373
68MP0001697_abnormal_embryo_size0.98795552
69MP0005360_urolithiasis0.98621085
70MP0000716_abnormal_immune_system0.97227017
71MP0002876_abnormal_thyroid_physiology0.96832289
72MP0002086_abnormal_extraembryonic_tissu0.96404726
73MP0000598_abnormal_liver_morphology0.96272770
74MP0001764_abnormal_homeostasis0.94231869
75MP0003786_premature_aging0.93270614
76MP0004197_abnormal_fetal_growth/weight/0.92919619
77MP0003984_embryonic_growth_retardation0.92863516
78MP0003123_paternal_imprinting0.92808739
79MP0000609_abnormal_liver_physiology0.92699108
80MP0009643_abnormal_urine_homeostasis0.92565761
81MP0005075_abnormal_melanosome_morpholog0.91977362
82MP0005380_embryogenesis_phenotype0.91488630
83MP0001672_abnormal_embryogenesis/_devel0.91488630
84MP0002088_abnormal_embryonic_growth/wei0.89812768
85MP0009642_abnormal_blood_homeostasis0.86772967
86MP0004233_abnormal_muscle_weight0.86573061
87MP0002095_abnormal_skin_pigmentation0.86167468
88MP0001835_abnormal_antigen_presentation0.85431878
89MP0002971_abnormal_brown_adipose0.84556078
90MP0008775_abnormal_heart_ventricle0.84276939
91MP0001800_abnormal_humoral_immune0.83095549
92MP0009931_abnormal_skin_appearance0.80751514
93MP0003959_abnormal_lean_body0.77417886
94MP0002089_abnormal_postnatal_growth/wei0.77264559
95MP0000749_muscle_degeneration0.76364785
96MP0000604_amyloidosis0.76348199
97MP0005584_abnormal_enzyme/coenzyme_acti0.75539176
98MP0008260_abnormal_autophagy0.75086904
99MP0000465_gastrointestinal_hemorrhage0.74721335
100MP0002006_tumorigenesis0.73430908
101MP0005376_homeostasis/metabolism_phenot0.72155888
102MP0005025_abnormal_response_to0.71424195
103MP0010368_abnormal_lymphatic_system0.70659105
104MP0005319_abnormal_enzyme/_coenzyme0.70611958
105MP0002420_abnormal_adaptive_immunity0.70492266
106MP0004185_abnormal_adipocyte_glucose0.70077543
107MP0009697_abnormal_copulation0.69167279
108MP0002970_abnormal_white_adipose0.68837445
109MP0001819_abnormal_immune_cell0.68663262
110MP0001243_abnormal_dermal_layer0.68518359
111MP0009785_altered_susceptibility_to0.67955872
112MP0005174_abnormal_tail_pigmentation0.67796963
113MP0010329_abnormal_lipoprotein_level0.67340459
114MP0006035_abnormal_mitochondrial_morpho0.66882735
115MP0001915_intracranial_hemorrhage0.66046403
116MP0002405_respiratory_system_inflammati0.65787874
117MP0005375_adipose_tissue_phenotype0.64081374
118MP0009763_increased_sensitivity_to0.63727993
119MP0002452_abnormal_antigen_presenting0.63339559
120MP0000358_abnormal_cell_content/0.63129565
121MP0002078_abnormal_glucose_homeostasis0.62979288
122MP0000858_altered_metastatic_potential0.62872636
123MP0005501_abnormal_skin_physiology0.62404245
124MP0009115_abnormal_fat_cell0.61846404
125MP0008770_decreased_survivor_rate0.61332968
126MP0005266_abnormal_metabolism0.61073147
127MP0003191_abnormal_cellular_cholesterol0.60677206
128MP0003943_abnormal_hepatobiliary_system0.60274322
129MP0008469_abnormal_protein_level0.60274015
130MP0009672_abnormal_birth_weight0.59025350
131MP0009379_abnormal_foot_pigmentation0.57978695
132MP0002419_abnormal_innate_immunity0.57894783
133MP0002723_abnormal_immune_serum0.57285233
134MP0002085_abnormal_embryonic_tissue0.57182219
135MP0000477_abnormal_intestine_morphology0.56918042
136MP0003718_maternal_effect0.56883840
137MP0010155_abnormal_intestine_physiology0.56302754
138MP0001845_abnormal_inflammatory_respons0.54946458
139MP0003303_peritoneal_inflammation0.54767175
140MP0005334_abnormal_fat_pad0.54447966
141MP0005395_other_phenotype0.53617386
142MP0000747_muscle_weakness0.53046676

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.67257309
2Poikilocytosis (HP:0004447)7.67689386
3Prolonged partial thromboplastin time (HP:0003645)6.71911744
4Abnormal number of erythroid precursors (HP:0012131)6.26173214
5Abnormality of cells of the erythroid lineage (HP:0012130)6.07320343
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.04808252
7Complement deficiency (HP:0004431)6.00941225
8Hypobetalipoproteinemia (HP:0003563)5.78783310
9Acanthocytosis (HP:0001927)5.49761735
10Joint hemorrhage (HP:0005261)5.37677696
11Abnormality of aromatic amino acid family metabolism (HP:0004338)5.20097714
12Reticulocytosis (HP:0001923)5.10406142
13Abnormality of complement system (HP:0005339)4.94428708
14Hypochromic microcytic anemia (HP:0004840)4.61588367
15Abnormality of reticulocytes (HP:0004312)4.57605269
16Birth length less than 3rd percentile (HP:0003561)4.47737105
17Systemic lupus erythematosus (HP:0002725)4.35636960
18Abnormality of the common coagulation pathway (HP:0010990)4.21788399
19Hyperbilirubinemia (HP:0002904)4.04612539
20Xanthomatosis (HP:0000991)3.91301446
21Glomerulonephritis (HP:0000099)3.80626962
22Reticulocytopenia (HP:0001896)3.63737050
23Cholelithiasis (HP:0001081)3.53942789
24Petechiae (HP:0000967)3.46549640
25Paralysis (HP:0003470)3.42092643
26Hypolipoproteinemia (HP:0010981)3.41203115
27Hemorrhage of the eye (HP:0011885)3.39414088
28Aplastic anemia (HP:0001915)3.37471112
29Spontaneous abortion (HP:0005268)3.32986133
30Diaphragmatic weakness (HP:0009113)3.28429955
31Conjugated hyperbilirubinemia (HP:0002908)3.26137914
32Microcytic anemia (HP:0001935)3.24831785
33Pallor (HP:0000980)3.23712476
34Prolonged bleeding time (HP:0003010)3.21203489
35Intrahepatic cholestasis (HP:0001406)3.15806699
36Macrocytic anemia (HP:0001972)3.11925325
37Abnormal gallbladder morphology (HP:0012437)3.09806945
38Abnormality of the intrinsic pathway (HP:0010989)3.07971464
39Hypochromic anemia (HP:0001931)3.05379967
40Increased serum ferritin (HP:0003281)2.97638728
41Menorrhagia (HP:0000132)2.94863807
42Hyperlipoproteinemia (HP:0010980)2.82619076
43Recurrent gram-negative bacterial infections (HP:0005420)2.82287191
44Thrombocytosis (HP:0001894)2.68101274
45Abnormality of iron homeostasis (HP:0011031)2.67903742
46Hypercholesterolemia (HP:0003124)2.63999785
47Cutaneous photosensitivity (HP:0000992)2.63976899
48Hyperammonemia (HP:0001987)2.62840557
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.59318974
50Fat malabsorption (HP:0002630)2.58853724
51Nausea (HP:0002018)2.56033241
52Epistaxis (HP:0000421)2.52706663
53Oral leukoplakia (HP:0002745)2.51164745
54Hepatocellular carcinoma (HP:0001402)2.46161818
55Myocardial infarction (HP:0001658)2.45401811
56Abnormality of transition element cation homeostasis (HP:0011030)2.41868389
57Hypoalphalipoproteinemia (HP:0003233)2.39166241
58Increased serum pyruvate (HP:0003542)2.37592015
59Insomnia (HP:0100785)2.37522726
60Polycythemia (HP:0001901)2.33059572
61Gout (HP:0001997)2.32224659
62Hyperglycinemia (HP:0002154)2.32199871
63Abnormality of glycolysis (HP:0004366)2.31191384
64IgM deficiency (HP:0002850)2.29433889
65Myelodysplasia (HP:0002863)2.26308910
66Osteomalacia (HP:0002749)2.25778474
67Abnormality of methionine metabolism (HP:0010901)2.23856047
68Nephritis (HP:0000123)2.23130194
69Abnormality of the gallbladder (HP:0005264)2.22803516
70Selective tooth agenesis (HP:0001592)2.17904047
71Abnormality of the Achilles tendon (HP:0005109)2.15054689
72Basal cell carcinoma (HP:0002671)2.14881280
73Abnormality of nucleobase metabolism (HP:0010932)2.13854062
74Abnormality of glycine metabolism (HP:0010895)2.13116320
75Abnormality of serine family amino acid metabolism (HP:0010894)2.13116320
76Breast hypoplasia (HP:0003187)2.09214030
77Seborrheic dermatitis (HP:0001051)2.08895032
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08693875
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08693875
80Cholecystitis (HP:0001082)2.08362224
81Abnormal gallbladder physiology (HP:0012438)2.08362224
82Steatorrhea (HP:0002570)2.06456199
83Acute hepatic failure (HP:0006554)2.03899656
84Short middle phalanx of the 5th finger (HP:0004220)2.03638841
85Nonimmune hydrops fetalis (HP:0001790)2.02882949
86Patellar aplasia (HP:0006443)2.00644308
87Abnormality of the heme biosynthetic pathway (HP:0010472)11.0235302
88Chromsome breakage (HP:0040012)1.98537808
89Hyperglycinuria (HP:0003108)1.97898675
90Purpura (HP:0000979)1.97894330
91Reduced antithrombin III activity (HP:0001976)1.95777137
92Ileus (HP:0002595)1.94193023
93Multiple enchondromatosis (HP:0005701)1.93020436
94Abnormality of sulfur amino acid metabolism (HP:0004339)1.91738842
95Generalized aminoaciduria (HP:0002909)1.91363168
96Pulmonary embolism (HP:0002204)1.91168724
97Rickets (HP:0002748)1.90060046
98Lymphoma (HP:0002665)1.89653278
99Abnormality of pyrimidine metabolism (HP:0004353)1.89492046
100Abnormality of chromosome stability (HP:0003220)1.88430096
101Impaired platelet aggregation (HP:0003540)1.88269174
102Abnormal platelet function (HP:0011869)1.88269174
103Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87438277
104Abnormal platelet volume (HP:0011876)1.86361876
10511 pairs of ribs (HP:0000878)1.84798954
106Microretrognathia (HP:0000308)1.83803657
107Abnormal enzyme/coenzyme activity (HP:0012379)1.83433027
108Vascular calcification (HP:0004934)1.82900578
109Recurrent viral infections (HP:0004429)1.82598465
110Aplasia/Hypoplasia of the patella (HP:0006498)1.80825868
111Broad palm (HP:0001169)1.80715660
112Abnormality of glutamine family amino acid metabolism (HP:0010902)1.79814691
113Medulloblastoma (HP:0002885)1.79600666
114B lymphocytopenia (HP:0010976)1.78943376
115Abnormality of B cell number (HP:0010975)1.78943376
116Pancytopenia (HP:0001876)1.76811431
117Spastic paraparesis (HP:0002313)1.76114176
118Colitis (HP:0002583)1.75972859
119Elevated alkaline phosphatase (HP:0003155)1.75049763
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74693943
121Abnormality of serum amino acid levels (HP:0003112)1.74179700
122Hypertriglyceridemia (HP:0002155)1.72980101
123Colon cancer (HP:0003003)1.70149767
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69329078
125Increased mean platelet volume (HP:0011877)1.68712961
126Abnormality of alkaline phosphatase activity (HP:0004379)1.68356666
127High pitched voice (HP:0001620)1.68100792
128Amaurosis fugax (HP:0100576)1.67826758
129Hypoglycemic coma (HP:0001325)1.67604942
130Meckel diverticulum (HP:0002245)1.66422365
131Lower limb hyperreflexia (HP:0002395)1.66385341
132Autoimmune thrombocytopenia (HP:0001973)1.65064916
133Abnormality of the ileum (HP:0001549)1.64768146
134Rhabdomyolysis (HP:0003201)1.63819538
135Increased serum lactate (HP:0002151)1.63270306
136Self-mutilation (HP:0000742)1.63176440
137Hypoplasia of the thymus (HP:0000778)1.63142317
138Cerebral palsy (HP:0100021)1.61508238
139Small intestinal stenosis (HP:0012848)1.61184837
140Duodenal stenosis (HP:0100867)1.61184837
141Vertebral compression fractures (HP:0002953)1.60667546
142Type I transferrin isoform profile (HP:0003642)1.57917175
143Abnormal hemoglobin (HP:0011902)1.57772335
144Abnormality of the thoracic spine (HP:0100711)1.57183355
145Abnormality of T cell physiology (HP:0011840)1.56506578
146Abnormality of the fingertips (HP:0001211)1.55711303
147Metabolic acidosis (HP:0001942)1.55709075
148Abnormality of T cells (HP:0002843)1.55496996
149Abnormality of the preputium (HP:0100587)1.55398478
150Elevated hepatic transaminases (HP:0002910)1.55211081
151Rhabdomyosarcoma (HP:0002859)1.54912930
152Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.54784274
153Abnormality of carpal bone ossification (HP:0006257)1.54662560
154Pustule (HP:0200039)1.54623225
155Panhypogammaglobulinemia (HP:0003139)1.54615776
156Slender long bone (HP:0003100)1.54225221
157Cellular immunodeficiency (HP:0005374)1.53568951
158Combined immunodeficiency (HP:0005387)1.51649164
159Pancreatic islet-cell hyperplasia (HP:0004510)1.51542044
160Gingival bleeding (HP:0000225)1.51120945
161Bone marrow hypocellularity (HP:0005528)1.50611108
162Hypoplasia of the pons (HP:0012110)1.50494420
163Thrombophlebitis (HP:0004418)1.50210878
164Abnormal spermatogenesis (HP:0008669)1.49216631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.34670958
2CDC74.08297256
3FGFR43.12610960
4NME23.10463045
5PRPF4B3.10309700
6WEE12.83587108
7SMG12.81316993
8NEK22.48604084
9BUB12.45480785
10EEF2K2.36700700
11ICK2.20948096
12IRAK32.09118054
13MAP3K102.03698109
14VRK12.03434413
15MAP2K31.91745986
16TLK11.88042600
17DYRK31.87859927
18FLT31.86516311
19NEK11.84498275
20STK41.83834281
21BRSK21.80224657
22ACVR1B1.80219429
23MAP4K11.74488628
24STK161.73425640
25MAP2K61.63249003
26BRSK11.62123576
27PKN21.56340926
28BCKDK1.55682387
29RPS6KB21.52521179
30STK101.52356754
31KDR1.51872308
32SRPK11.50847051
33ATR1.50655650
34CDK41.46031089
35TGFBR11.45169251
36AURKB1.44556113
37SCYL21.44507479
38EIF2AK31.40002214
39PIM21.35267668
40TTK1.33345909
41PIM11.30214540
42PLK11.28298429
43CCNB11.27152297
44CDK71.26284430
45PLK41.19658947
46CAMK1D1.19046024
47MAPK111.18835176
48MAP3K81.17836368
49RPS6KA41.16156931
50MAP3K111.13010309
51ZAK1.12930227
52MKNK11.10968799
53LRRK21.05100930
54FGFR31.01114289
55CHEK20.99262367
56TRIB30.97841810
57TGFBR20.96823306
58AURKA0.96696584
59CDK60.95224137
60BTK0.92473506
61GRK60.91695372
62WNK40.91193514
63TYK20.90582521
64RIPK40.87166663
65CLK10.84536593
66MAPKAPK30.83249224
67TAOK10.82892704
68CHEK10.82543024
69JAK30.81814304
70PASK0.81801826
71SYK0.81279431
72CDK120.80829334
73TEC0.80009640
74PRKAA20.79762963
75ERN10.78034458
76MTOR0.77527288
77PDPK10.77217620
78ITK0.77114581
79MAP3K10.76044087
80RPS6KA50.71004950
81ATM0.70903585
82MAP3K130.70403624
83WNK10.70368438
84KIT0.69705495
85TSSK60.66376318
86CAMK1G0.65993371
87CDK80.64520736
88ZAP700.62450995
89TESK20.62421239
90EIF2AK20.62329178
91VRK20.62203282
92PDK10.61851477
93LYN0.61263511
94RIPK10.61142315
95TAOK20.60871858
96TAOK30.60477478
97CSF1R0.60299351
98DYRK1B0.59607623
99BMX0.57628871
100MAP3K50.57128190
101CSNK2A10.55917517
102CDK20.54297649
103JAK20.53846168
104SIK10.53808398
105CSNK2A20.52094435
106MKNK20.51080985
107IRAK40.49299393
108TBK10.48219016
109BRD40.48133545
110MAPKAPK50.47718805
111TRPM70.47270139
112PBK0.47267713
113MAP3K60.44651249
114MAPK120.44312015
115PLK30.44055151
116RPS6KB10.43802361
117TNK20.41822960
118TIE10.41648280
119RPS6KL10.41083441
120RPS6KC10.41083441
121MAP2K20.40959338
122PRKAA10.40800160
123CDK190.40780640
124RAF10.40648765
125ILK0.40480357
126PAK40.40006042
127FES0.39000201
128KSR20.38784788
129CDK10.38015808
130AKT20.37991079
131MAP3K30.36375074
132PRKACG0.36016112
133IKBKB0.34633293
134MAPKAPK20.33784637
135RPS6KA60.31057033
136ABL20.30523472
137PIK3CG0.29702525
138IKBKE0.29307330

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.55512863
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.15366508
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.97628230
4Mismatch repair_Homo sapiens_hsa034303.91976828
5Ribosome_Homo sapiens_hsa030103.60101824
6Base excision repair_Homo sapiens_hsa034102.94431707
7Arginine biosynthesis_Homo sapiens_hsa002202.66560346
8One carbon pool by folate_Homo sapiens_hsa006702.62877400
9Homologous recombination_Homo sapiens_hsa034402.58376095
10Nucleotide excision repair_Homo sapiens_hsa034202.54251297
11Cell cycle_Homo sapiens_hsa041102.49054958
12Spliceosome_Homo sapiens_hsa030402.41941377
13Systemic lupus erythematosus_Homo sapiens_hsa053222.32112171
14Pyrimidine metabolism_Homo sapiens_hsa002402.23757065
15Phenylalanine metabolism_Homo sapiens_hsa003602.19283299
16Retinol metabolism_Homo sapiens_hsa008302.09130659
17Proteasome_Homo sapiens_hsa030502.02955751
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00258389
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93515116
20Non-homologous end-joining_Homo sapiens_hsa034501.92859405
21RNA transport_Homo sapiens_hsa030131.86974228
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74397010
23RNA polymerase_Homo sapiens_hsa030201.72400420
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71494474
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.70326320
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69397524
27Sulfur relay system_Homo sapiens_hsa041221.68545971
28Fanconi anemia pathway_Homo sapiens_hsa034601.66979815
29Tyrosine metabolism_Homo sapiens_hsa003501.66056722
30Chemical carcinogenesis_Homo sapiens_hsa052041.61322145
31Other glycan degradation_Homo sapiens_hsa005111.53079448
32Fat digestion and absorption_Homo sapiens_hsa049751.51802433
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50203093
34Fatty acid metabolism_Homo sapiens_hsa012121.40881478
35Vitamin B6 metabolism_Homo sapiens_hsa007501.39284160
36Arginine and proline metabolism_Homo sapiens_hsa003301.38866432
37Starch and sucrose metabolism_Homo sapiens_hsa005001.38436723
38p53 signaling pathway_Homo sapiens_hsa041151.31313900
39RNA degradation_Homo sapiens_hsa030181.30127081
40Butanoate metabolism_Homo sapiens_hsa006501.29325251
41Folate biosynthesis_Homo sapiens_hsa007901.28984185
42Selenocompound metabolism_Homo sapiens_hsa004501.28150482
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.21685648
44Bile secretion_Homo sapiens_hsa049761.20751742
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.20529973
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19406156
47Staphylococcus aureus infection_Homo sapiens_hsa051501.16436661
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.14047905
49Histidine metabolism_Homo sapiens_hsa003401.07303476
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06867837
51Purine metabolism_Homo sapiens_hsa002301.04490026
52Fructose and mannose metabolism_Homo sapiens_hsa000511.03065555
53Herpes simplex infection_Homo sapiens_hsa051681.02406856
54Prion diseases_Homo sapiens_hsa050201.00957577
55Biosynthesis of amino acids_Homo sapiens_hsa012300.99492843
56Pentose phosphate pathway_Homo sapiens_hsa000300.97743326
57Primary immunodeficiency_Homo sapiens_hsa053400.96272102
58Basal transcription factors_Homo sapiens_hsa030220.95967484
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91396570
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90819611
61Viral carcinogenesis_Homo sapiens_hsa052030.90360869
62Hematopoietic cell lineage_Homo sapiens_hsa046400.89239402
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88327849
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87974606
65mRNA surveillance pathway_Homo sapiens_hsa030150.86786227
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.86190475
67Caffeine metabolism_Homo sapiens_hsa002320.85092299
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84846671
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83680092
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81065026
71Alcoholism_Homo sapiens_hsa050340.79900395
72Carbon metabolism_Homo sapiens_hsa012000.79401122
73Glutathione metabolism_Homo sapiens_hsa004800.74437753
74Vitamin digestion and absorption_Homo sapiens_hsa049770.73139953
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.71897389
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.71442670
77ABC transporters_Homo sapiens_hsa020100.68455691
78Antigen processing and presentation_Homo sapiens_hsa046120.67037851
79Steroid biosynthesis_Homo sapiens_hsa001000.66582005
80Epstein-Barr virus infection_Homo sapiens_hsa051690.64912255
81Fatty acid biosynthesis_Homo sapiens_hsa000610.62365439
82Pyruvate metabolism_Homo sapiens_hsa006200.62228750
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60665975
84Fatty acid elongation_Homo sapiens_hsa000620.60088991
85Thyroid cancer_Homo sapiens_hsa052160.59455326
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57894251
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56654400
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56600545
89Small cell lung cancer_Homo sapiens_hsa052220.55549994
90Measles_Homo sapiens_hsa051620.53500086
91N-Glycan biosynthesis_Homo sapiens_hsa005100.52783774
92HTLV-I infection_Homo sapiens_hsa051660.52354961
93Arachidonic acid metabolism_Homo sapiens_hsa005900.52234007
94Linoleic acid metabolism_Homo sapiens_hsa005910.52192694
95Renin-angiotensin system_Homo sapiens_hsa046140.51995183
96Sulfur metabolism_Homo sapiens_hsa009200.51959822
97Fatty acid degradation_Homo sapiens_hsa000710.51225265
98Chronic myeloid leukemia_Homo sapiens_hsa052200.50799069
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50795392
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50181003
101Protein export_Homo sapiens_hsa030600.49805424
102Propanoate metabolism_Homo sapiens_hsa006400.49021265
103Insulin resistance_Homo sapiens_hsa049310.47585971
104Complement and coagulation cascades_Homo sapiens_hsa046100.47184745
105Bladder cancer_Homo sapiens_hsa052190.43763624
106Parkinsons disease_Homo sapiens_hsa050120.43126248
107Peroxisome_Homo sapiens_hsa041460.43002493
108Apoptosis_Homo sapiens_hsa042100.42992726
109Lysine degradation_Homo sapiens_hsa003100.42963395
110Acute myeloid leukemia_Homo sapiens_hsa052210.42771369
111Hepatitis B_Homo sapiens_hsa051610.42090953
112Legionellosis_Homo sapiens_hsa051340.41400893
113Metabolic pathways_Homo sapiens_hsa011000.41114236
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40860743
115Pertussis_Homo sapiens_hsa051330.39784279
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39754477
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37638231
118Glycerolipid metabolism_Homo sapiens_hsa005610.37305561
119Galactose metabolism_Homo sapiens_hsa000520.36472141
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36385337
121beta-Alanine metabolism_Homo sapiens_hsa004100.36266990
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36093086
123Oocyte meiosis_Homo sapiens_hsa041140.31340943
124Non-small cell lung cancer_Homo sapiens_hsa052230.30628917
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.30248221
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30132686
127Malaria_Homo sapiens_hsa051440.27200621
128Huntingtons disease_Homo sapiens_hsa050160.26875307
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.26867629
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23987720
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23827276
132Tryptophan metabolism_Homo sapiens_hsa003800.23335103
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.22741716
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21509067
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20633030
136MicroRNAs in cancer_Homo sapiens_hsa052060.20197112
137PPAR signaling pathway_Homo sapiens_hsa033200.18083745
138Glucagon signaling pathway_Homo sapiens_hsa049220.17592149
139AMPK signaling pathway_Homo sapiens_hsa041520.17353627
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.17253007
141Influenza A_Homo sapiens_hsa051640.16235865
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12853204
143Insulin signaling pathway_Homo sapiens_hsa049100.11269460

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