SLC3A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.64312407
2regulation of translational fidelity (GO:0006450)4.78242260
3L-serine metabolic process (GO:0006563)4.54341150
4L-alpha-amino acid transmembrane transport (GO:1902475)4.20689220
5positive regulation by symbiont of host defense response (GO:0052509)4.07548280
6modulation by symbiont of host defense response (GO:0052031)4.07548280
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07548280
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07548280
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.07548280
10modulation by symbiont of host immune response (GO:0052553)4.07548280
11protein complex localization (GO:0031503)3.92526811
12cellular protein complex localization (GO:0034629)3.81583501
13protein maturation by protein folding (GO:0022417)3.77508025
14desmosome organization (GO:0002934)3.72966467
15regulation of translational termination (GO:0006449)3.71476312
16proline biosynthetic process (GO:0006561)3.66654894
17pentose-phosphate shunt (GO:0006098)3.63501297
18spliceosomal tri-snRNP complex assembly (GO:0000244)3.59877533
19nuclear envelope reassembly (GO:0031468)3.55823912
20mitotic nuclear envelope reassembly (GO:0007084)3.55823912
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.53458197
22tRNA aminoacylation for protein translation (GO:0006418)3.51249711
23folic acid-containing compound biosynthetic process (GO:0009396)3.45386695
24NADPH regeneration (GO:0006740)3.44504328
25response to peptidoglycan (GO:0032494)3.44436596
26nuclear pore complex assembly (GO:0051292)3.42396538
27COPI coating of Golgi vesicle (GO:0048205)3.36120489
28Golgi transport vesicle coating (GO:0048200)3.36120489
29tRNA aminoacylation (GO:0043039)3.35794915
30amino acid activation (GO:0043038)3.35794915
31peptidyl-arginine omega-N-methylation (GO:0035247)3.35174796
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.35116196
33ER overload response (GO:0006983)3.33903476
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33465165
35positive regulation of chemokine biosynthetic process (GO:0045080)3.33179200
36mitochondrial DNA metabolic process (GO:0032042)3.30236200
37glucose 6-phosphate metabolic process (GO:0051156)3.27279642
38nucleobase-containing small molecule interconversion (GO:0015949)3.21479864
39mitotic chromosome condensation (GO:0007076)3.21092420
40glucose catabolic process (GO:0006007)3.20762093
41cell-substrate junction assembly (GO:0007044)3.19493926
42chaperone mediated protein folding requiring cofactor (GO:0051085)3.16712256
43DNA unwinding involved in DNA replication (GO:0006268)3.14395449
44protein localization to endosome (GO:0036010)3.13480039
45wound healing, spreading of epidermal cells (GO:0035313)3.13193323
46immunoglobulin mediated immune response (GO:0016064)3.10563794
47ribosome biogenesis (GO:0042254)3.09972771
48regulation of interferon-beta biosynthetic process (GO:0045357)3.07183332
49serine transport (GO:0032329)3.06973288
50positive regulation of interferon-alpha production (GO:0032727)3.06151443
51histone arginine methylation (GO:0034969)3.03009988
52pore complex assembly (GO:0046931)2.98398824
53L-serine transport (GO:0015825)2.97973135
54intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.97560882
55regulation of interferon-alpha production (GO:0032647)2.92895666
56positive regulation of heat generation (GO:0031652)2.92001926
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90440188
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90440188
59regulation of mammary gland epithelial cell proliferation (GO:0033599)2.90087884
60protein retention in ER lumen (GO:0006621)2.87925528
61positive regulation of keratinocyte differentiation (GO:0045618)2.87614929
62pentose metabolic process (GO:0019321)2.84920322
63GDP-mannose metabolic process (GO:0019673)2.83116154
64regulation of early endosome to late endosome transport (GO:2000641)2.82676425
65signal peptide processing (GO:0006465)2.82207761
66epithelial cell-cell adhesion (GO:0090136)2.81445934
67nuclear pore organization (GO:0006999)2.81239611
68lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80487857
69activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.80363558
70response to muramyl dipeptide (GO:0032495)2.80044499
71cellular copper ion homeostasis (GO:0006878)2.79590030
72tRNA methylation (GO:0030488)2.79440458
73endoplasmic reticulum unfolded protein response (GO:0030968)2.78002151
74positive regulation of nuclease activity (GO:0032075)2.77763261
75DNA strand elongation (GO:0022616)2.77655435
76serine family amino acid biosynthetic process (GO:0009070)2.76626446
77regulation of podosome assembly (GO:0071801)2.76616055
78DNA strand elongation involved in DNA replication (GO:0006271)2.76440102
79B cell mediated immunity (GO:0019724)2.74725551
80regulation of fever generation (GO:0031620)2.71317829
81cellular response to unfolded protein (GO:0034620)2.71160799
82macrophage activation involved in immune response (GO:0002281)2.70083853
83regulation of translational elongation (GO:0006448)2.69239928
84regulation of nuclease activity (GO:0032069)2.67369123
85positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66231982
86establishment of integrated proviral latency (GO:0075713)2.65559568
87apoptotic cell clearance (GO:0043277)2.64154849
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63291337
89adherens junction assembly (GO:0034333)2.63220552
90respiratory burst (GO:0045730)2.63149705
91peptidyl-arginine N-methylation (GO:0035246)2.62468134
92peptidyl-arginine methylation (GO:0018216)2.62468134
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61934902
94peptidyl-proline hydroxylation (GO:0019511)2.61557584
95regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.61090982
96neutrophil activation involved in immune response (GO:0002283)2.60894235
97protein hydroxylation (GO:0018126)2.60614418
98antigen processing and presentation of endogenous antigen (GO:0019883)2.60075280
99response to unfolded protein (GO:0006986)2.59329734
100positive regulation of interferon-beta production (GO:0032728)2.58592242
101regulation of chemokine biosynthetic process (GO:0045073)2.57558290
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.56877640
103natural killer cell mediated cytotoxicity (GO:0042267)2.56600061
104natural killer cell mediated immunity (GO:0002228)2.56600061
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55938011
106cell-substrate adherens junction assembly (GO:0007045)2.55821248
107focal adhesion assembly (GO:0048041)2.55821248
108cellular response to topologically incorrect protein (GO:0035967)2.54466690
109response to arsenic-containing substance (GO:0046685)2.52148041
110endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49168805
111positive regulation of epidermis development (GO:0045684)2.48782422
112mitochondrial fusion (GO:0008053)2.47769541
113apoptotic process involved in morphogenesis (GO:0060561)2.47544089
114regulation of water loss via skin (GO:0033561)2.47480091
115cell adhesion mediated by integrin (GO:0033627)2.47145898
116rRNA transcription (GO:0009303)2.46473662
117hydrogen peroxide biosynthetic process (GO:0050665)2.46161327
118response to host immune response (GO:0052572)2.45818244
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45818244
120ribonucleoprotein complex biogenesis (GO:0022613)2.45569237
121establishment of viral latency (GO:0019043)2.45203204
122response to topologically incorrect protein (GO:0035966)2.44965955
123mitotic nuclear envelope disassembly (GO:0007077)2.44406360
124pinocytosis (GO:0006907)2.44127155
125cellular response to arsenic-containing substance (GO:0071243)2.43608221
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.43555387
127activation of Rac GTPase activity (GO:0032863)2.43374173
128wound healing, spreading of cells (GO:0044319)2.43237932
129monosaccharide biosynthetic process (GO:0046364)2.42381038
130positive regulation of hair follicle development (GO:0051798)2.42305116
131positive regulation of hair cycle (GO:0042635)2.42305116
132microglial cell activation (GO:0001774)2.40540621
133myeloid cell homeostasis (GO:0002262)2.40447019
134ER-nucleus signaling pathway (GO:0006984)2.39353188
135chaperone-mediated protein folding (GO:0061077)2.39010054
136eosinophil chemotaxis (GO:0048245)2.38840816
137regulation of interleukin-12 biosynthetic process (GO:0045075)2.37786536
138protein export from nucleus (GO:0006611)2.37725917
139DNA replication initiation (GO:0006270)2.37563347
140decidualization (GO:0046697)2.36269543
141negative regulation of interleukin-12 production (GO:0032695)2.36203034
142positive regulation of lymphocyte apoptotic process (GO:0070230)2.35733126
143T cell apoptotic process (GO:0070231)2.35272484
144granulocyte activation (GO:0036230)2.34106984
145cellular response to interferon-alpha (GO:0035457)2.34033838
146positive regulation of leukocyte degranulation (GO:0043302)2.33713602
147SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.33643369
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.31671932
149negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.31495468
150response to type I interferon (GO:0034340)2.30744944
151type I interferon signaling pathway (GO:0060337)2.29825594
152cellular response to type I interferon (GO:0071357)2.29825594
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.29823564
154regulation of protein heterodimerization activity (GO:0043497)2.29295582
155protein targeting to ER (GO:0045047)2.28896836
156regulation of vitamin D biosynthetic process (GO:0060556)2.26770331
157response to endoplasmic reticulum stress (GO:0034976)2.26632560
158NIK/NF-kappaB signaling (GO:0038061)2.25294110
159glycolipid catabolic process (GO:0019377)2.24832754
160cotranslational protein targeting to membrane (GO:0006613)2.23744867
161response to host (GO:0075136)2.22508865
162response to host defenses (GO:0052200)2.22508865
163response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.22508865
164eosinophil migration (GO:0072677)2.22294378
165basic amino acid transport (GO:0015802)2.22042256
166positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.21300392
167formation of translation preinitiation complex (GO:0001731)2.21033210
168activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.20851750
169exocrine pancreas development (GO:0031017)2.19670223
170cellular response to virus (GO:0098586)2.18605200
171interferon-gamma secretion (GO:0072643)2.18226606
172monocyte chemotaxis (GO:0002548)2.17724105
173ribosome assembly (GO:0042255)2.16633463
174establishment of endothelial barrier (GO:0061028)2.16507158
175positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.15918099
176establishment of protein localization to endoplasmic reticulum (GO:0072599)2.15693103
177leukocyte apoptotic process (GO:0071887)2.13915094
178neutrophil activation (GO:0042119)2.13745715
179reactive oxygen species biosynthetic process (GO:1903409)2.13532892
180sequestering of metal ion (GO:0051238)2.13214186
181positive regulation of NF-kappaB import into nucleus (GO:0042346)2.11986191
182production of molecular mediator involved in inflammatory response (GO:0002532)2.11828021
183positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.11754734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.06477869
2E2F7_22180533_ChIP-Seq_HELA_Human3.84341811
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.26945875
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.13251980
5* ZNF263_19887448_ChIP-Seq_K562_Human2.99099424
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.82030928
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61303825
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.57290558
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51332028
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49162730
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24469612
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04641597
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03937237
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03937237
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03937237
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99988518
17MYC_22102868_ChIP-Seq_BL_Human1.97149718
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95664468
19* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93005428
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85606065
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85151326
22FOXM1_23109430_ChIP-Seq_U2OS_Human1.84246729
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.83709598
24* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83285582
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80633150
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79844611
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79425753
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79361634
29* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79101820
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78143563
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77162711
32TFEB_21752829_ChIP-Seq_HELA_Human1.75516558
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75171023
34* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74676873
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71432919
36* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64762034
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60313096
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59687509
39VDR_21846776_ChIP-Seq_THP-1_Human1.55591854
40* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55562117
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52434355
42SPI1_23547873_ChIP-Seq_NB4_Human1.50582861
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.50029183
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49029169
45* GABP_19822575_ChIP-Seq_HepG2_Human1.48780252
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48725665
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48571277
48* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.48133552
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.48011870
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47378113
51* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47166803
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46823857
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44543213
54ATF3_27146783_Chip-Seq_COLON_Human1.44296199
55* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43328361
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41715507
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40192076
58ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39056476
59LXR_22292898_ChIP-Seq_THP-1_Human1.36723872
60MAF_26560356_Chip-Seq_TH1_Human1.36354118
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35625357
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34331486
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33318966
64* XRN2_22483619_ChIP-Seq_HELA_Human1.31945443
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31301801
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.30878207
67* DCP1A_22483619_ChIP-Seq_HELA_Human1.30469089
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30377728
69* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29607594
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.29411331
71CLOCK_20551151_ChIP-Seq_293T_Human1.28961855
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.27065156
73* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26438460
74* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25458883
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24989825
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24864432
77VDR_24763502_ChIP-Seq_THP-1_Human1.24823100
78* KDM5A_27292631_Chip-Seq_BREAST_Human1.24778609
79* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23917236
80MYB_26560356_Chip-Seq_TH2_Human1.23579564
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23319466
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22451839
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21902255
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21899895
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21024702
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20084091
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19457027
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.17640290
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15702442
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15292319
91* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15162989
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14690430
93* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14673156
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.14521402
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13774054
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13423572
97* VDR_23849224_ChIP-Seq_CD4+_Human1.13028187
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12801959
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11982804
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.11935330
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.10682193
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.09761378
103ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09477327
104* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09171159
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09115395
106* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09083032
107UTX_26944678_Chip-Seq_JUKART_Human1.08818967
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08539072
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08126125
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.08104282
111* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06818190
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06627537
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06536550
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06380907
115* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06058767
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05683063
117MYB_26560356_Chip-Seq_TH1_Human1.04658129
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04428598
119ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04222021
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03996666
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03970593
122ELK1_22589737_ChIP-Seq_MCF10A_Human1.03639758
123* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03412675
124* TCF7_22412390_ChIP-Seq_EML_Mouse1.02241106
125RACK7_27058665_Chip-Seq_MCF-7_Human1.01711838
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01425755
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.01095183
128* E2F1_21310950_ChIP-Seq_MCF-7_Human1.01007902
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00976929
130* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00819876
131* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00331579
132* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00328365
133* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00328365
134NCOR1_26117541_ChIP-Seq_K562_Human0.99638474
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99484490
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99343552
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99177508
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98928402
139TP53_22127205_ChIP-Seq_IMR90_Human0.98713447
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.98272962
141* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98045988
142IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97999475
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97916715
144KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97830568
145* TTF2_22483619_ChIP-Seq_HELA_Human0.97499436
146ELK1_19687146_ChIP-ChIP_HELA_Human0.97150802
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97071082
148AR_21909140_ChIP-Seq_LNCAP_Human0.96640240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.45814556
2MP0000579_abnormal_nail_morphology3.42074734
3MP0010234_abnormal_vibrissa_follicle2.91963122
4MP0004233_abnormal_muscle_weight2.90062288
5MP0008260_abnormal_autophagy2.82808812
6MP0003436_decreased_susceptibility_to2.67976369
7MP0002796_impaired_skin_barrier2.59054450
8MP0005058_abnormal_lysosome_morphology2.58372776
9MP0005501_abnormal_skin_physiology2.44667933
10MP0005451_abnormal_body_composition2.43666471
11MP0010352_gastrointestinal_tract_polyps2.37764786
12MP0001849_ear_inflammation2.31965765
13MP0001835_abnormal_antigen_presentation2.22948312
14MP0003806_abnormal_nucleotide_metabolis2.13766370
15MP0000537_abnormal_urethra_morphology2.03118621
16MP0003693_abnormal_embryo_hatching2.00901779
17MP0003724_increased_susceptibility_to2.00303156
18MP0003300_gastrointestinal_ulcer2.00055643
19MP0010094_abnormal_chromosome_stability1.99670362
20MP0003566_abnormal_cell_adhesion1.99188408
21MP0005000_abnormal_immune_tolerance1.94908474
22MP0002877_abnormal_melanocyte_morpholog1.92583709
23MP0002419_abnormal_innate_immunity1.90794998
24MP0009785_altered_susceptibility_to1.89410741
25MP0005076_abnormal_cell_differentiation1.88600759
26MP0002060_abnormal_skin_morphology1.88432732
27MP0000858_altered_metastatic_potential1.85964996
28MP0003448_altered_tumor_morphology1.84033337
29MP0006082_CNS_inflammation1.80871865
30MP0001533_abnormal_skeleton_physiology1.80053398
31MP0009278_abnormal_bone_marrow1.78476759
32MP0002148_abnormal_hypersensitivity_rea1.76880174
33MP0002098_abnormal_vibrissa_morphology1.75536175
34MP0002452_abnormal_antigen_presenting1.73588986
35MP0001216_abnormal_epidermal_layer1.70471191
36MP0009333_abnormal_splenocyte_physiolog1.64071092
37MP0009840_abnormal_foam_cell1.63995059
38MP0005025_abnormal_response_to1.63758217
39MP0001853_heart_inflammation1.63142629
40MP0001730_embryonic_growth_arrest1.61899273
41MP0000685_abnormal_immune_system1.61348628
42MP0010307_abnormal_tumor_latency1.61081108
43MP0004947_skin_inflammation1.61000252
44MP0002405_respiratory_system_inflammati1.57451903
45MP0003172_abnormal_lysosome_physiology1.57293920
46MP0001790_abnormal_immune_system1.57222344
47MP0005387_immune_system_phenotype1.57222344
48MP0002723_abnormal_immune_serum1.52620586
49MP0000467_abnormal_esophagus_morphology1.51580053
50MP0005671_abnormal_response_to1.49556523
51MP0005257_abnormal_intraocular_pressure1.47710916
52MP0001819_abnormal_immune_cell1.43730329
53MP0004782_abnormal_surfactant_physiolog1.43558541
54MP0004381_abnormal_hair_follicle1.42399389
55MP0001800_abnormal_humoral_immune1.42360954
56MP0008438_abnormal_cutaneous_collagen1.42348528
57MP0002420_abnormal_adaptive_immunity1.41736888
58MP0008007_abnormal_cellular_replicative1.37673220
59MP0005023_abnormal_wound_healing1.35996804
60MP0004510_myositis1.35231398
61MP0000377_abnormal_hair_follicle1.33679252
62MP0002998_abnormal_bone_remodeling1.32830015
63MP0010030_abnormal_orbit_morphology1.32035381
64MP0001845_abnormal_inflammatory_respons1.30763703
65MP0000490_abnormal_crypts_of1.30723440
66MP0009672_abnormal_birth_weight1.27753719
67MP0010771_integument_phenotype1.27125434
68MP0000762_abnormal_tongue_morphology1.26952571
69MP0000343_altered_response_to1.25021197
70MP0001958_emphysema1.24115243
71MP0005623_abnormal_meninges_morphology1.22676511
72* MP0002080_prenatal_lethality1.22414282
73MP0008058_abnormal_DNA_repair1.21908262
74MP0003279_aneurysm1.21758955
75MP0003186_abnormal_redox_activity1.18169849
76MP0004957_abnormal_blastocyst_morpholog1.18109197
77MP0005390_skeleton_phenotype1.18081075
78MP0001545_abnormal_hematopoietic_system1.15593541
79MP0005397_hematopoietic_system_phenotyp1.15593541
80MP0010155_abnormal_intestine_physiology1.13959427
81MP0001542_abnormal_bone_strength1.12910789
82MP0003453_abnormal_keratinocyte_physiol1.11594288
83MP0003091_abnormal_cell_migration1.11097043
84MP0010678_abnormal_skin_adnexa1.10557060
85MP0002254_reproductive_system_inflammat1.09887006
86MP0003705_abnormal_hypodermis_morpholog1.09545270
87MP0005464_abnormal_platelet_physiology1.08606465
88MP0005380_embryogenesis_phenotype1.07858340
89MP0001672_abnormal_embryogenesis/_devel1.07858340
90MP0003077_abnormal_cell_cycle1.07610384
91MP0005167_abnormal_blood-brain_barrier1.07281543
92MP0002933_joint_inflammation1.07235079
93MP0003111_abnormal_nucleus_morphology1.06483460
94MP0002398_abnormal_bone_marrow1.06113938
95MP0005408_hypopigmentation1.03878082
96MP0003191_abnormal_cellular_cholesterol1.03774714
97* MP0000358_abnormal_cell_content/1.03549414
98MP0003329_amyloid_beta_deposits1.03244473
99MP0001243_abnormal_dermal_layer1.02209977
100MP0005310_abnormal_salivary_gland1.02188418
101MP0003795_abnormal_bone_structure1.02096535
102MP0000716_abnormal_immune_system1.02061724
103MP0002089_abnormal_postnatal_growth/wei1.01600410
104MP0004185_abnormal_adipocyte_glucose1.00562312
105MP0009931_abnormal_skin_appearance0.99474134
106MP0001697_abnormal_embryo_size0.99030904
107* MP0005384_cellular_phenotype0.98990142
108MP0000003_abnormal_adipose_tissue0.98695657
109MP0005409_darkened_coat_color0.98115656
110MP0000689_abnormal_spleen_morphology0.97182234
111MP0002086_abnormal_extraembryonic_tissu0.96767177
112MP0002722_abnormal_immune_system0.96391592
113MP0003984_embryonic_growth_retardation0.95918849
114MP0000678_abnormal_parathyroid_gland0.95386435
115MP0003941_abnormal_skin_development0.94603206
116MP0002429_abnormal_blood_cell0.94570369
117MP0000350_abnormal_cell_proliferation0.92923477
118MP0004808_abnormal_hematopoietic_stem0.92892667
119MP0002090_abnormal_vision0.92181359
120MP0008469_abnormal_protein_level0.91733223
121MP0009053_abnormal_anal_canal0.91265741
122MP0005197_abnormal_uvea_morphology0.90595737
123MP0006054_spinal_hemorrhage0.90276672
124MP0003828_pulmonary_edema0.90169150
125MP0002697_abnormal_eye_size0.89657270
126MP0002088_abnormal_embryonic_growth/wei0.89348737
127MP0000750_abnormal_muscle_regeneration0.89340323
128MP0000015_abnormal_ear_pigmentation0.89109326
129MP0004858_abnormal_nervous_system0.88792595
130MP0003221_abnormal_cardiomyocyte_apopto0.88509502
131MP0000371_diluted_coat_color0.88508789
132MP0002075_abnormal_coat/hair_pigmentati0.88113563
133MP0009764_decreased_sensitivity_to0.86773678
134MP0001186_pigmentation_phenotype0.86762932
135MP0005621_abnormal_cell_physiology0.86273080
136MP0003786_premature_aging0.85422383
137MP0003075_altered_response_to0.85400652
138MP0003763_abnormal_thymus_physiology0.85269195
139MP0002693_abnormal_pancreas_physiology0.84856633
140MP0004197_abnormal_fetal_growth/weight/0.84627099
141MP0005075_abnormal_melanosome_morpholog0.83338311
142MP0002138_abnormal_hepatobiliary_system0.81874855
143MP0002006_tumorigenesis0.81866061
144MP0000383_abnormal_hair_follicle0.81687424
145MP0001915_intracranial_hemorrhage0.80935315
146MP0000372_irregular_coat_pigmentation0.80760416
147MP0001881_abnormal_mammary_gland0.80280131
148MP0002136_abnormal_kidney_physiology0.80150216
149MP0000367_abnormal_coat/_hair0.78962449
150MP0000627_abnormal_mammary_gland0.78836607
151MP0001348_abnormal_lacrimal_gland0.78781984
152MP0000733_abnormal_muscle_development0.78534199
153MP0005164_abnormal_response_to0.78316467
154MP0001661_extended_life_span0.78304695
155MP0008932_abnormal_embryonic_tissue0.77356447
156MP0005248_abnormal_Harderian_gland0.77050600
157MP0001873_stomach_inflammation0.77038889
158MP0003183_abnormal_peptide_metabolism0.76864013
159MP0002085_abnormal_embryonic_tissue0.76557920
160MP0002019_abnormal_tumor_incidence0.74083348
161MP0000313_abnormal_cell_death0.73185284
162MP0004272_abnormal_basement_membrane0.72588854
163MP0004264_abnormal_extraembryonic_tissu0.72270466
164MP0005165_increased_susceptibility_to0.72210524

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.73264500
2Recurrent abscess formation (HP:0002722)3.94710649
3Vacuolated lymphocytes (HP:0001922)3.71648775
4Increased cerebral lipofuscin (HP:0011813)3.65755187
5Abnormality of macrophages (HP:0004311)3.63579480
6Abnormality of liposaccharide metabolism (HP:0010968)3.44410698
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.44410698
8Abnormality of glycolipid metabolism (HP:0010969)3.44410698
9Interstitial pulmonary disease (HP:0006530)3.41136833
10Dysostosis multiplex (HP:0000943)3.35661843
11Milia (HP:0001056)3.35295547
12Recurrent bacterial skin infections (HP:0005406)3.34744313
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.32631073
14Fragile nails (HP:0001808)3.26171901
15Hyperacusis (HP:0010780)3.14253582
16Tetraparesis (HP:0002273)3.03942194
17Atrophic scars (HP:0001075)3.01800954
18Thick nail (HP:0001805)3.00260041
19Nail dystrophy (HP:0008404)2.98624008
20Abnormality of nail color (HP:0100643)2.96153094
21Basal ganglia calcification (HP:0002135)2.93227592
22Progressive muscle weakness (HP:0003323)2.91400661
23Mediastinal lymphadenopathy (HP:0100721)2.90587004
24Microvesicular hepatic steatosis (HP:0001414)2.90204973
25Plantar hyperkeratosis (HP:0007556)2.89219636
26Elevated erythrocyte sedimentation rate (HP:0003565)2.84712256
27Urinary glycosaminoglycan excretion (HP:0003541)2.79234107
28Mucopolysacchariduria (HP:0008155)2.79234107
29Vertebral compression fractures (HP:0002953)2.76697707
30Ragged-red muscle fibers (HP:0003200)2.71414879
31Natal tooth (HP:0000695)2.69545969
32Pili torti (HP:0003777)2.68105261
33Pterygium (HP:0001059)2.66994497
34Premature rupture of membranes (HP:0001788)2.65151108
35Abnormality of polysaccharide metabolism (HP:0011012)2.64520581
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64520581
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64520581
38Stomatitis (HP:0010280)2.62597562
39Premature loss of primary teeth (HP:0006323)2.53583448
40Gingivitis (HP:0000230)2.47440239
41Cervical subluxation (HP:0003308)2.46546064
42Sparse eyelashes (HP:0000653)2.45270983
43Insomnia (HP:0100785)2.45036848
44Abnormal gallbladder physiology (HP:0012438)2.44712499
45Cholecystitis (HP:0001082)2.44712499
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42476087
47Deviation of the thumb (HP:0009603)2.41593099
48Achilles tendon contracture (HP:0001771)2.41412659
49Alopecia of scalp (HP:0002293)2.40996015
50Poor head control (HP:0002421)2.39152226
51Hand muscle atrophy (HP:0009130)2.39110097
52Hypokinesia (HP:0002375)2.38198697
53Ulnar bowing (HP:0003031)2.35043130
54Autoimmune thrombocytopenia (HP:0001973)2.33962177
55Long palpebral fissure (HP:0000637)2.30995228
56Recurrent gram-negative bacterial infections (HP:0005420)2.29727688
57Spastic diplegia (HP:0001264)2.27709336
58Myositis (HP:0100614)2.25255532
59Multiple enchondromatosis (HP:0005701)2.25151023
60Short nail (HP:0001799)2.24938571
61Selective tooth agenesis (HP:0001592)2.24229000
62Trismus (HP:0000211)2.23737518
63Proximal placement of thumb (HP:0009623)2.23594509
64Septate vagina (HP:0001153)2.21381948
65Abnormality of the umbilical cord (HP:0010881)2.18156756
66Broad face (HP:0000283)2.16086224
67Distal lower limb amyotrophy (HP:0008944)2.15619010
68Recurrent fungal infections (HP:0002841)2.13026853
69Abnormal hair laboratory examination (HP:0003328)2.12790768
70Loss of speech (HP:0002371)2.12789874
71Pustule (HP:0200039)2.12787779
72Orchitis (HP:0100796)2.12501126
73Squamous cell carcinoma (HP:0002860)2.12193439
74Fragile skin (HP:0001030)2.11488752
75Cellulitis (HP:0100658)2.10007955
76Abnormality of the distal phalanges of the toes (HP:0010182)2.09545344
77Progressive external ophthalmoplegia (HP:0000590)2.09499196
78Cerebral aneurysm (HP:0004944)2.08828198
79Obstructive lung disease (HP:0006536)2.06727096
80Chronic obstructive pulmonary disease (HP:0006510)2.06727096
81Palmoplantar hyperkeratosis (HP:0000972)2.06367320
82Distal lower limb muscle weakness (HP:0009053)2.05463530
83Nuclear cataract (HP:0100018)2.04522737
84Advanced eruption of teeth (HP:0006288)2.03657368
85Abnormality of the Achilles tendon (HP:0005109)2.02392528
86Abnormality of oral frenula (HP:0000190)2.02318962
87Overriding aorta (HP:0002623)2.01602678
88Myocardial infarction (HP:0001658)2.01600036
89Aplasia cutis congenita (HP:0001057)2.01588823
90Ankyloglossia (HP:0010296)2.00602632
91Fasciculations (HP:0002380)1.98030212
92Abnormalities of placenta or umbilical cord (HP:0001194)1.96473879
93Difficulty climbing stairs (HP:0003551)1.95344685
94Ridged nail (HP:0001807)1.93399587
95Abnormality of glycolysis (HP:0004366)1.93249046
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.93078757
97Osteolytic defects of the hand bones (HP:0009699)1.93078757
98Cerebral inclusion bodies (HP:0100314)1.92905943
99Joint stiffness (HP:0001387)1.92035465
100Petechiae (HP:0000967)1.89295345
101Palmar hyperkeratosis (HP:0010765)1.88922013
102Carpal bone hypoplasia (HP:0001498)1.87288761
103Hematochezia (HP:0002573)1.86883479
104Elbow flexion contracture (HP:0002987)1.86775024
105Reticulocytosis (HP:0001923)1.86654967
106Abnormal trabecular bone morphology (HP:0100671)1.85354862
107Abnormality of the anterior horn cell (HP:0006802)1.84942820
108Degeneration of anterior horn cells (HP:0002398)1.84942820
109Upper limb muscle weakness (HP:0003484)1.84779123
110Entropion (HP:0000621)1.83569098
111Urticaria (HP:0001025)1.83359391
112Agnosia (HP:0010524)1.81675462
113Micronodular cirrhosis (HP:0001413)1.81382734
114Pathologic fracture (HP:0002756)1.81177115
115Generalized amyotrophy (HP:0003700)1.80494156
116Reticulocytopenia (HP:0001896)1.80243424
117Death in infancy (HP:0001522)1.79036322
118Recurrent viral infections (HP:0004429)1.78804695
119Diaphragmatic weakness (HP:0009113)1.78431000
120Prolonged neonatal jaundice (HP:0006579)1.78426926
121Fused cervical vertebrae (HP:0002949)1.78224396
122Upper limb amyotrophy (HP:0009129)1.76647242
123Distal upper limb amyotrophy (HP:0007149)1.76647242
124Sparse lateral eyebrow (HP:0005338)1.76168253
125Porencephaly (HP:0002132)1.75436894
126Recurrent skin infections (HP:0001581)1.75356528
127Breast hypoplasia (HP:0003187)1.75034657
128Personality changes (HP:0000751)1.72192858
129Ureteral duplication (HP:0000073)1.71628593
130Abnormality of the salivary glands (HP:0010286)1.71502119
131Neurofibrillary tangles (HP:0002185)1.71269288
132Distal sensory impairment (HP:0002936)1.70947677
133Osteomyelitis (HP:0002754)1.70416275
134Hyperparathyroidism (HP:0000843)1.70342005
135Right ventricular cardiomyopathy (HP:0011663)1.69801350
136Retrobulbar optic neuritis (HP:0100654)1.68582355
137Optic neuritis (HP:0100653)1.68582355
138Progressive neurologic deterioration (HP:0002344)1.67698969
139Hammertoe (HP:0001765)1.67352748
140Back pain (HP:0003418)1.66422947
141Abnormal blistering of the skin (HP:0008066)1.66056529
142Severe short stature (HP:0003510)1.65462437
143Nonimmune hydrops fetalis (HP:0001790)1.65122259
144Absent eyelashes (HP:0000561)1.64758969
145Protrusio acetabuli (HP:0003179)1.64549642
146Increased connective tissue (HP:0009025)1.62931147
147Spinal muscular atrophy (HP:0007269)1.62834819
148Emphysema (HP:0002097)1.62537251
149Leukocytosis (HP:0001974)1.62285181
150Lower limb amyotrophy (HP:0007210)1.61287999
151Overlapping toe (HP:0001845)1.61133832
152Pallor (HP:0000980)1.60990125
153J-shaped sella turcica (HP:0002680)1.60592793
154Increased density of long bones (HP:0006392)1.59115957
155Adactyly (HP:0009776)1.58950649
156Retinal atrophy (HP:0001105)1.57982471
157Cheilitis (HP:0100825)1.57468399
158Increased IgM level (HP:0003496)1.56754221
159Diminished motivation (HP:0000745)1.56702725
160Coxa valga (HP:0002673)1.56632012
161Peritonitis (HP:0002586)1.55865953
162Recurrent pneumonia (HP:0006532)1.55353507
163Genu recurvatum (HP:0002816)1.55052724
164Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.53925809
165Persistence of primary teeth (HP:0006335)1.52231579
166Metaphyseal cupping (HP:0003021)1.52148008
167Rough bone trabeculation (HP:0100670)1.50060371
168Thrombocytosis (HP:0001894)1.49796695
169Blepharitis (HP:0000498)1.48210719
170Beaking of vertebral bodies (HP:0004568)1.47909329
171Axonal loss (HP:0003447)1.47509753
172Pulmonary infiltrates (HP:0002113)1.46703069
173Bone pain (HP:0002653)1.46190285
174Anorexia (HP:0002039)1.45284186
175Esophageal varix (HP:0002040)1.45159721
176Vasculitis (HP:0002633)1.43548595
177Aseptic necrosis (HP:0010885)1.43180244
178Onycholysis (HP:0001806)1.42910389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.30097376
2ERN13.65478316
3EPHA23.34497907
4SMG13.05173118
5NME23.02294575
6MST1R2.94992065
7PIM22.62642596
8TBK12.53497314
9PDK22.28667232
10ARAF2.24641752
11SIK12.18913120
12BLK2.10004156
13ICK2.01922342
14PBK1.97989761
15MAP3K141.91493501
16LATS21.91014508
17IRAK41.87551480
18JAK31.82492753
19TYK21.77443368
20RPS6KA41.70058159
21KDR1.67933475
22STK101.54918105
23IKBKB1.53422530
24BMX1.47317436
25TRIB31.45971703
26LMTK21.45626585
27MAP4K11.45148938
28PAK41.45089684
29PRPF4B1.44907526
30IKBKE1.42714435
31SCYL21.41589621
32MAP3K31.40464896
33ZAP701.37658945
34PIM11.36886295
35VRK21.31121713
36MAPKAPK31.27985341
37TTN1.27107053
38EEF2K1.26879997
39IRAK11.26168802
40CHUK1.25179982
41ERBB41.22676567
42LRRK21.21361657
43EIF2AK11.19445795
44KIT1.18436310
45CDK121.14150357
46BUB11.14139074
47TAOK21.14037997
48TGFBR21.12531964
49EPHB11.12482079
50SRPK11.12254967
51TAOK31.12004761
52PASK1.09995954
53RIPK11.08110777
54EIF2AK31.07735393
55NEK11.06601582
56EPHA31.06187983
57MAP2K21.05636233
58TSSK61.05026057
59MAPK151.04567367
60MAP3K81.02706010
61MAP3K91.01370807
62CSK0.99881781
63TESK20.99754354
64WEE10.98897520
65TLK10.98345382
66ALK0.98171820
67BRAF0.97850964
68MST40.96076632
69NEK90.95707129
70FGFR40.95581962
71SIK30.93932662
72RPS6KB20.91887843
73MAPKAPK50.89127410
74JAK10.88294812
75LIMK10.87376986
76NTRK10.87376239
77AURKA0.85074571
78MAP3K110.83187800
79TESK10.82468987
80DDR20.76267519
81CDK70.73252630
82PTK60.73244434
83MARK30.72937029
84CHEK20.72453794
85MATK0.71433564
86NEK20.69139032
87KSR20.68850124
88FLT30.68419140
89TXK0.66990693
90CDK60.66000649
91STK160.65250478
92RAF10.64124064
93RPS6KA50.64047229
94BRSK10.62467178
95PRKD30.62278313
96PTK20.62065726
97DYRK1B0.61330864
98CHEK10.61246164
99LATS10.61045385
100AKT20.60638024
101RIPK40.60544710
102LYN0.60077151
103BCKDK0.59340449
104TTK0.59206762
105MAP3K100.58488322
106NLK0.58187413
107HIPK20.57992545
108HCK0.57823641
109MAP2K30.56727348
110PAK20.56156108
111CDC70.56081882
112JAK20.54402240
113MET0.54334029
114NME10.54019525
115PDGFRA0.53609811
116ABL20.52732585
117DAPK30.52691308
118BTK0.52600808
119MAPK110.52180613
120LCK0.51475955
121PLK10.51193969
122BRD40.50887074
123MTOR0.50679258
124PLK40.49776981
125PKN20.49573807
126MAPKAPK20.48745446
127RPS6KA20.48192580
128PRKG20.48153442
129CDK90.48129800
130NEK60.47981748
131TAOK10.47434132
132PRKCI0.46998696
133ATR0.46010808
134RPS6KA10.45764601
135FGFR30.45557348
136CDK80.45326575
137DYRK30.45314759
138MOS0.44851146
139TRIM280.44602987
140TGFBR10.43058773
141CAMK2G0.42661710
142PAK10.42268934
143AURKB0.41374919
144MAP3K10.41312154
145ABL10.40950075
146CDK40.40687764
147IRAK20.40070029
148DAPK10.38903315
149CLK10.38598432
150CSNK1G30.36436787
151CSNK1A1L0.36217872
152RPS6KL10.33110742
153RPS6KC10.33110742

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of amino acids_Homo sapiens_hsa012302.53675516
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35946531
3Pentose phosphate pathway_Homo sapiens_hsa000302.30543150
4Legionellosis_Homo sapiens_hsa051342.18141232
5Leishmaniasis_Homo sapiens_hsa051402.15310452
6Lysosome_Homo sapiens_hsa041421.99495517
7Other glycan degradation_Homo sapiens_hsa005111.98519888
8Fructose and mannose metabolism_Homo sapiens_hsa000511.92906811
9Vitamin B6 metabolism_Homo sapiens_hsa007501.89872793
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.89724546
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.89256340
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84969749
13One carbon pool by folate_Homo sapiens_hsa006701.84372850
14Protein export_Homo sapiens_hsa030601.81293618
15Antigen processing and presentation_Homo sapiens_hsa046121.75893656
16Carbon metabolism_Homo sapiens_hsa012001.74820441
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.71802338
18Vibrio cholerae infection_Homo sapiens_hsa051101.71624033
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69551887
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65434474
21Malaria_Homo sapiens_hsa051441.64130758
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62659436
23Measles_Homo sapiens_hsa051621.53244764
24Osteoclast differentiation_Homo sapiens_hsa043801.49681007
25TNF signaling pathway_Homo sapiens_hsa046681.45989444
26Apoptosis_Homo sapiens_hsa042101.45533554
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44147723
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43924469
29Graft-versus-host disease_Homo sapiens_hsa053321.41412552
30Herpes simplex infection_Homo sapiens_hsa051681.38337135
31Sulfur relay system_Homo sapiens_hsa041221.37565121
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36716348
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32404420
34DNA replication_Homo sapiens_hsa030301.31935810
35Tuberculosis_Homo sapiens_hsa051521.31527802
36Influenza A_Homo sapiens_hsa051641.31081921
37Steroid biosynthesis_Homo sapiens_hsa001001.31035677
38Ribosome_Homo sapiens_hsa030101.31016921
39Asthma_Homo sapiens_hsa053101.30610050
40p53 signaling pathway_Homo sapiens_hsa041151.29817605
41Pertussis_Homo sapiens_hsa051331.29001992
42Proteasome_Homo sapiens_hsa030501.25000399
43Toxoplasmosis_Homo sapiens_hsa051451.24766464
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22906941
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22869806
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22436509
47Type I diabetes mellitus_Homo sapiens_hsa049401.19700295
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17699702
49Rheumatoid arthritis_Homo sapiens_hsa053231.16926778
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16543219
51Selenocompound metabolism_Homo sapiens_hsa004501.11711019
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.11304591
53mRNA surveillance pathway_Homo sapiens_hsa030151.11066578
54Renin-angiotensin system_Homo sapiens_hsa046141.10484591
55Fatty acid elongation_Homo sapiens_hsa000621.09136153
56Thyroid cancer_Homo sapiens_hsa052161.09085840
57Hematopoietic cell lineage_Homo sapiens_hsa046401.08926075
58Epstein-Barr virus infection_Homo sapiens_hsa051691.08542011
59Allograft rejection_Homo sapiens_hsa053301.07567073
60Small cell lung cancer_Homo sapiens_hsa052221.07458568
61Shigellosis_Homo sapiens_hsa051311.06949270
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.04858258
63Hepatitis B_Homo sapiens_hsa051611.02052476
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.01479925
65RNA transport_Homo sapiens_hsa030131.00000487
66Mismatch repair_Homo sapiens_hsa034300.99941579
67Phagosome_Homo sapiens_hsa041450.99063906
68Salmonella infection_Homo sapiens_hsa051320.97305884
69Viral carcinogenesis_Homo sapiens_hsa052030.96694326
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95594362
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94783774
72Folate biosynthesis_Homo sapiens_hsa007900.94303240
73RNA polymerase_Homo sapiens_hsa030200.92814096
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91212271
75Spliceosome_Homo sapiens_hsa030400.91067181
76Mineral absorption_Homo sapiens_hsa049780.90813925
77Base excision repair_Homo sapiens_hsa034100.90055653
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89506529
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88379241
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88225477
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.88058196
82N-Glycan biosynthesis_Homo sapiens_hsa005100.86182598
83Glutathione metabolism_Homo sapiens_hsa004800.86121088
84Chronic myeloid leukemia_Homo sapiens_hsa052200.86082045
85Non-homologous end-joining_Homo sapiens_hsa034500.85581927
86HTLV-I infection_Homo sapiens_hsa051660.85210976
87* Protein digestion and absorption_Homo sapiens_hsa049740.84567977
88Bladder cancer_Homo sapiens_hsa052190.83512318
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.82765988
90Acute myeloid leukemia_Homo sapiens_hsa052210.81383350
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80630791
92Hepatitis C_Homo sapiens_hsa051600.78637945
93Notch signaling pathway_Homo sapiens_hsa043300.76336517
94B cell receptor signaling pathway_Homo sapiens_hsa046620.75822450
95Pyruvate metabolism_Homo sapiens_hsa006200.75789813
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74918989
97Cell cycle_Homo sapiens_hsa041100.74169776
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74142361
99Sphingolipid metabolism_Homo sapiens_hsa006000.72805175
100MicroRNAs in cancer_Homo sapiens_hsa052060.70557826
101Amoebiasis_Homo sapiens_hsa051460.68097880
102HIF-1 signaling pathway_Homo sapiens_hsa040660.67964144
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67302731
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65123566
105Pyrimidine metabolism_Homo sapiens_hsa002400.65116235
106Adherens junction_Homo sapiens_hsa045200.65052379
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63639212
108Viral myocarditis_Homo sapiens_hsa054160.63264975
109Nucleotide excision repair_Homo sapiens_hsa034200.62869525
110Arginine biosynthesis_Homo sapiens_hsa002200.62335624
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61949333
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61848831
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.61497455
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61265870
115Pancreatic cancer_Homo sapiens_hsa052120.61068021
116Homologous recombination_Homo sapiens_hsa034400.60769469
117Prolactin signaling pathway_Homo sapiens_hsa049170.60261431
118ECM-receptor interaction_Homo sapiens_hsa045120.59310692
119Vitamin digestion and absorption_Homo sapiens_hsa049770.59098248
120Chemokine signaling pathway_Homo sapiens_hsa040620.58929070
121Hippo signaling pathway_Homo sapiens_hsa043900.57993797
122Proteoglycans in cancer_Homo sapiens_hsa052050.57428725
123Staphylococcus aureus infection_Homo sapiens_hsa051500.56654974
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56635878
125Prostate cancer_Homo sapiens_hsa052150.55529692
126Galactose metabolism_Homo sapiens_hsa000520.53164226
127Prion diseases_Homo sapiens_hsa050200.51286476
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.51161472
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51101476
130Synaptic vesicle cycle_Homo sapiens_hsa047210.49930468
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48404196
132Arginine and proline metabolism_Homo sapiens_hsa003300.43425292
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43054542
134Collecting duct acid secretion_Homo sapiens_hsa049660.40762831
135Endometrial cancer_Homo sapiens_hsa052130.39830549
136ErbB signaling pathway_Homo sapiens_hsa040120.39678398
137Endocytosis_Homo sapiens_hsa041440.38310438
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37976886
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37365466
140Purine metabolism_Homo sapiens_hsa002300.37205598
141Insulin signaling pathway_Homo sapiens_hsa049100.35151410
142Fanconi anemia pathway_Homo sapiens_hsa034600.33149779
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32785061
144AMPK signaling pathway_Homo sapiens_hsa041520.31189872
145Focal adhesion_Homo sapiens_hsa045100.30696000
146Renal cell carcinoma_Homo sapiens_hsa052110.29484410

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