SLC38A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51184392
2L-phenylalanine catabolic process (GO:0006559)7.51184392
3L-phenylalanine metabolic process (GO:0006558)7.15129390
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.15129390
5exogenous drug catabolic process (GO:0042738)7.07167252
6aromatic amino acid family catabolic process (GO:0009074)6.70840676
7epoxygenase P450 pathway (GO:0019373)6.45853372
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.35885204
9tryptophan catabolic process (GO:0006569)6.05580260
10indole-containing compound catabolic process (GO:0042436)6.05580260
11indolalkylamine catabolic process (GO:0046218)6.05580260
12omega-hydroxylase P450 pathway (GO:0097267)6.03967466
13regulation of plasminogen activation (GO:0010755)5.99960035
14kynurenine metabolic process (GO:0070189)5.96210450
15bile acid biosynthetic process (GO:0006699)5.80827309
16alpha-linolenic acid metabolic process (GO:0036109)5.70386276
17tryptophan metabolic process (GO:0006568)5.68660072
18glyoxylate metabolic process (GO:0046487)5.64017431
19high-density lipoprotein particle remodeling (GO:0034375)5.54601324
20urea cycle (GO:0000050)5.49157538
21urea metabolic process (GO:0019627)5.49157538
22negative regulation of fibrinolysis (GO:0051918)5.41809064
23cysteine metabolic process (GO:0006534)5.32401274
24regulation of fibrinolysis (GO:0051917)5.26431375
25protein carboxylation (GO:0018214)5.25377956
26peptidyl-glutamic acid carboxylation (GO:0017187)5.25377956
27sulfur amino acid catabolic process (GO:0000098)5.22123119
28regulation of protein activation cascade (GO:2000257)5.14712913
29serine family amino acid catabolic process (GO:0009071)5.07848088
30complement activation, alternative pathway (GO:0006957)5.07336078
31nitrogen cycle metabolic process (GO:0071941)5.04394451
32bile acid metabolic process (GO:0008206)4.99011231
33negative regulation of hemostasis (GO:1900047)4.94762417
34negative regulation of blood coagulation (GO:0030195)4.94762417
35drug metabolic process (GO:0017144)4.93268849
36reverse cholesterol transport (GO:0043691)4.92887223
37regulation of cholesterol esterification (GO:0010872)4.85418357
38aromatic amino acid family metabolic process (GO:0009072)4.84517111
39plasma lipoprotein particle remodeling (GO:0034369)4.78563844
40protein-lipid complex remodeling (GO:0034368)4.78563844
41macromolecular complex remodeling (GO:0034367)4.78563844
42regulation of complement activation (GO:0030449)4.78484731
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75242374
44homocysteine metabolic process (GO:0050667)4.71416042
45regulation of triglyceride catabolic process (GO:0010896)4.71131635
46tyrosine metabolic process (GO:0006570)4.68994150
47oxidative demethylation (GO:0070989)4.68056766
48alpha-amino acid catabolic process (GO:1901606)4.66648888
49lysine catabolic process (GO:0006554)4.62086601
50lysine metabolic process (GO:0006553)4.62086601
51positive regulation of hemostasis (GO:1900048)4.60976569
52positive regulation of blood coagulation (GO:0030194)4.60976569
53amino-acid betaine metabolic process (GO:0006577)4.56358205
54triglyceride homeostasis (GO:0070328)4.55646181
55acylglycerol homeostasis (GO:0055090)4.55646181
56negative regulation of cholesterol transport (GO:0032375)4.55577101
57negative regulation of sterol transport (GO:0032372)4.55577101
58phospholipid efflux (GO:0033700)4.52587764
59phenylpropanoid metabolic process (GO:0009698)4.51630107
60negative regulation of coagulation (GO:0050819)4.50723446
61cellular ketone body metabolic process (GO:0046950)4.49813802
62ethanol metabolic process (GO:0006067)4.43419606
63coenzyme catabolic process (GO:0009109)4.40033402
64glutamate metabolic process (GO:0006536)4.39920229
65negative regulation of wound healing (GO:0061045)4.37581178
66imidazole-containing compound metabolic process (GO:0052803)4.32166585
67cellular amino acid catabolic process (GO:0009063)4.29405335
68plasma lipoprotein particle clearance (GO:0034381)4.28229584
69bile acid and bile salt transport (GO:0015721)4.27564941
70indolalkylamine metabolic process (GO:0006586)4.26666989
71glycine metabolic process (GO:0006544)4.26540338
72cellular biogenic amine catabolic process (GO:0042402)4.24626398
73amine catabolic process (GO:0009310)4.24626398
74cellular glucuronidation (GO:0052695)4.24123393
75positive regulation of coagulation (GO:0050820)4.22379423
76cellular modified amino acid catabolic process (GO:0042219)4.21218649
77cholesterol efflux (GO:0033344)4.20331322
78dicarboxylic acid biosynthetic process (GO:0043650)4.18230919
79low-density lipoprotein particle remodeling (GO:0034374)4.16953231
80regulation of apoptotic cell clearance (GO:2000425)4.15662577
81acute-phase response (GO:0006953)4.14257290
82serine family amino acid metabolic process (GO:0009069)4.09812688
83regulation of humoral immune response (GO:0002920)4.09211126
84ethanol oxidation (GO:0006069)4.05135970
85benzene-containing compound metabolic process (GO:0042537)4.02111006
86plasma lipoprotein particle assembly (GO:0034377)3.98295160
87protein-lipid complex subunit organization (GO:0071825)3.97631449
88arginine metabolic process (GO:0006525)3.97060953
89serine family amino acid biosynthetic process (GO:0009070)3.96477244
90negative regulation of protein activation cascade (GO:2000258)3.96203617
91drug catabolic process (GO:0042737)3.89320504
92ketone body metabolic process (GO:1902224)3.89058385
93positive regulation of fatty acid biosynthetic process (GO:0045723)3.88671696
94fibrinolysis (GO:0042730)3.87706105
95regulation of bile acid biosynthetic process (GO:0070857)3.87465447
96regulation of lipoprotein particle clearance (GO:0010984)3.78792690
97regulation of cholesterol homeostasis (GO:2000188)3.78623913
98alkaloid metabolic process (GO:0009820)3.78292365
99short-chain fatty acid metabolic process (GO:0046459)3.75564921
100very-low-density lipoprotein particle assembly (GO:0034379)3.74961539
101phospholipid homeostasis (GO:0055091)3.74891703
102proline metabolic process (GO:0006560)3.74774701
103aldehyde catabolic process (GO:0046185)3.74372289
104glucuronate metabolic process (GO:0019585)3.74305785
105uronic acid metabolic process (GO:0006063)3.74305785
106organic acid catabolic process (GO:0016054)3.73505647
107carboxylic acid catabolic process (GO:0046395)3.73505647
108blood coagulation, intrinsic pathway (GO:0007597)3.70606444
109negative regulation of lipase activity (GO:0060192)3.70005334
110cofactor catabolic process (GO:0051187)3.69614501
111positive regulation of lipid catabolic process (GO:0050996)3.68723893
112cholesterol homeostasis (GO:0042632)3.67887837
113plasma lipoprotein particle organization (GO:0071827)3.66092919
114acetyl-CoA metabolic process (GO:0006084)3.64777147
115complement activation, classical pathway (GO:0006958)3.64545077
116positive regulation of triglyceride lipase activity (GO:0061365)3.63477665
117positive regulation of lipoprotein lipase activity (GO:0051006)3.63477665
118S-adenosylmethionine metabolic process (GO:0046500)3.62640688
119sterol homeostasis (GO:0055092)3.61736712
120protein activation cascade (GO:0072376)3.60877960
121complement activation (GO:0006956)3.60722781
122protein-lipid complex assembly (GO:0065005)3.56879152
123aspartate family amino acid catabolic process (GO:0009068)3.55918873
124heme transport (GO:0015886)3.55804238
125negative regulation of lipid transport (GO:0032369)3.55226205
126positive regulation of fatty acid beta-oxidation (GO:0032000)3.47878282
127intestinal cholesterol absorption (GO:0030299)3.47145150
128flavonoid metabolic process (GO:0009812)3.42260548
129response to mercury ion (GO:0046689)3.41367244
130lipoprotein metabolic process (GO:0042157)3.36368150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.19176199
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.97892311
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.63235553
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.38824760
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24366904
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.74684757
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64104154
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00229799
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.72137756
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04903202
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5656838
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87398669
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79255305
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.65158069
15HTT_18923047_ChIP-ChIP_STHdh_Human1.59412248
16CLOCK_20551151_ChIP-Seq_293T_Human1.53753239
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44208925
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37783086
19GATA1_22025678_ChIP-Seq_K562_Human1.23012807
20* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11165383
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.10756345
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06886920
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06416785
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01774478
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00101237
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99985621
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99423568
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94561120
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90648668
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90326734
31AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87962908
32RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87438382
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86500944
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86083238
35SMC4_20622854_ChIP-Seq_HELA_Human0.82521393
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81118793
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80344571
38SOX2_21211035_ChIP-Seq_LN229_Human0.79614476
39ESR2_21235772_ChIP-Seq_MCF-7_Human0.77883664
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76447095
41RAC3_21632823_ChIP-Seq_H3396_Human0.76105583
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74282407
43* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.72553771
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72368627
45* GATA4_25053715_ChIP-Seq_YYC3_Human0.71667571
46TCF4_18268006_ChIP-ChIP_LS174T_Human0.70822632
47SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70729528
48NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70311497
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70311497
50GATA6_25053715_ChIP-Seq_YYC3_Human0.69920585
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69620053
52CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69017580
53DROSHA_22980978_ChIP-Seq_HELA_Human0.67959459
54SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67744132
55KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67523808
56* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.66493268
57* RARA_24833708_ChIP-Seq_LIVER_Mouse0.66122308
58RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65206446
59ZNF263_19887448_ChIP-Seq_K562_Human0.65140627
60SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63915006
61ERG_21242973_ChIP-ChIP_JURKAT_Human0.63192622
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.62821362
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.62667724
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.62451002
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61374575
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61138299
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.60494840
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60158501
69SA1_27219007_Chip-Seq_Bcells_Human0.60109454
70OCT4_20526341_ChIP-Seq_ESCs_Human0.58511918
71* LXR_22292898_ChIP-Seq_THP-1_Human0.57940088
72CBP_21632823_ChIP-Seq_H3396_Human0.56940142
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56398121
74RARB_24833708_ChIP-Seq_LIVER_Mouse0.56146200
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.55696169
76JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.55324894
77MYC_19829295_ChIP-Seq_ESCs_Human0.54823858
78BCAT_22108803_ChIP-Seq_LS180_Human0.54757838
79SOX2_20726797_ChIP-Seq_SW620_Human0.54437577
80FOXA1_25552417_ChIP-Seq_VCAP_Human0.53925845
81CTCF_20526341_ChIP-Seq_ESCs_Human0.53729985
82EGR1_19032775_ChIP-ChIP_M12_Human0.53519865
83* CEBPB_22108803_ChIP-Seq_LS180_Human0.53480832
84ESR1_20079471_ChIP-ChIP_T-47D_Human0.52795441
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.52721487
86* E2F1_20622854_ChIP-Seq_HELA_Human0.52599011
87TAF15_26573619_Chip-Seq_HEK293_Human0.52556683
88AR_20517297_ChIP-Seq_VCAP_Human0.51228847
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51151814
90MYC_19915707_ChIP-ChIP_AK7_Human0.51043689
91IRF8_22096565_ChIP-ChIP_GC-B_Human0.50753860
92SOX11_22085726_ChIP-Seq_ESNs_Mouse0.49697882
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.49377974
94CSB_26484114_Chip-Seq_FIBROBLAST_Human0.48918124
95ESET_19884257_ChIP-Seq_ESCs_Mouse0.48745140
96P68_20966046_ChIP-Seq_HELA_Human0.48422278
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.48397315
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.48241156
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.48122956
100STAT1_17558387_ChIP-Seq_HELA_Human0.47728674
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.47586939
102MYC_27129775_Chip-Seq_CORNEA_Mouse0.47345831
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47255633
104* ELF1_20517297_ChIP-Seq_JURKAT_Human0.47034735
105TAF2_19829295_ChIP-Seq_ESCs_Human0.46882714
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.46865315
107* P53_21459846_ChIP-Seq_SAOS-2_Human0.46208587
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46189193
109GATA1_19941826_ChIP-Seq_K562_Human0.46166225
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45955655
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.45557116
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43469563
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.43447075
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.42839725
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.42540357
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.41741817
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.41729104
118GATA2_19941826_ChIP-Seq_K562_Human0.41036848
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41021946
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.39903158
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39657529
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39325275
123* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.38979823
124CTCF_27219007_Chip-Seq_Bcells_Human0.38844461
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38283247
126LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.38143546
127FOXH1_21741376_ChIP-Seq_EPCs_Human0.37315745
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.37171884
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.36912458
130DNAJC2_21179169_ChIP-ChIP_NT2_Human0.36821351
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.35680614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.23958209
2MP0005360_urolithiasis7.49304809
3MP0005085_abnormal_gallbladder_physiolo6.38926428
4MP0005365_abnormal_bile_salt6.15440226
5MP0008875_abnormal_xenobiotic_pharmacok5.11475598
6MP0003806_abnormal_nucleotide_metabolis4.16441224
7MP0003252_abnormal_bile_duct3.82761872
8MP0010329_abnormal_lipoprotein_level3.61373118
9MP0009840_abnormal_foam_cell3.32076600
10MP0005083_abnormal_biliary_tract3.22483353
11MP0003195_calcinosis2.83595342
12MP0005332_abnormal_amino_acid2.81868104
13MP0001666_abnormal_nutrient_absorption2.67442641
14MP0003191_abnormal_cellular_cholesterol2.20909744
15MP0004019_abnormal_vitamin_homeostasis2.18755454
16MP0002118_abnormal_lipid_homeostasis2.13633002
17MP0000609_abnormal_liver_physiology2.10993297
18MP0003868_abnormal_feces_composition1.96262520
19MP0003011_delayed_dark_adaptation1.84531136
20MP0002138_abnormal_hepatobiliary_system1.80292551
21MP0005319_abnormal_enzyme/_coenzyme1.79346859
22MP0001764_abnormal_homeostasis1.66976809
23MP0005584_abnormal_enzyme/coenzyme_acti1.57025138
24MP0009697_abnormal_copulation1.55127700
25MP0005451_abnormal_body_composition1.36970968
26MP0000566_synostosis1.30272242
27MP0003656_abnormal_erythrocyte_physiolo1.22235421
28MP0002254_reproductive_system_inflammat1.18670034
29MP0009643_abnormal_urine_homeostasis1.18653688
30MP0003122_maternal_imprinting1.17416145
31MP0003186_abnormal_redox_activity1.15708072
32MP0005647_abnormal_sex_gland1.15080789
33MP0000604_amyloidosis1.14286356
34MP0003705_abnormal_hypodermis_morpholog1.10782905
35MP0000598_abnormal_liver_morphology1.10066623
36MP0003879_abnormal_hair_cell1.08033249
37MP0001915_intracranial_hemorrhage1.03799826
38MP0002132_abnormal_respiratory_system1.03554012
39MP0009764_decreased_sensitivity_to1.02123474
40MP0010368_abnormal_lymphatic_system0.99389009
41MP0009763_increased_sensitivity_to0.95730203
42MP0005670_abnormal_white_adipose0.91060228
43MP0003690_abnormal_glial_cell0.87887680
44MP0005636_abnormal_mineral_homeostasis0.87074345
45MP0005058_abnormal_lysosome_morphology0.85950732
46MP0009642_abnormal_blood_homeostasis0.84510919
47MP0005084_abnormal_gallbladder_morpholo0.83368208
48MP0003329_amyloid_beta_deposits0.82471821
49MP0002089_abnormal_postnatal_growth/wei0.82461207
50MP0002078_abnormal_glucose_homeostasis0.79629633
51MP0004130_abnormal_muscle_cell0.79115045
52MP0008469_abnormal_protein_level0.78920037
53MP0005376_homeostasis/metabolism_phenot0.78696881
54MP0006036_abnormal_mitochondrial_physio0.78351276
55MP0002971_abnormal_brown_adipose0.76828805
56MP0005220_abnormal_exocrine_pancreas0.76479966
57MP0002249_abnormal_larynx_morphology0.75397581
58MP0002876_abnormal_thyroid_physiology0.72703093
59MP0005535_abnormal_body_temperature0.72095750
60MP0005408_hypopigmentation0.71853698
61MP0009765_abnormal_xenobiotic_induced0.70509944
62MP0001661_extended_life_span0.70287377
63MP0005334_abnormal_fat_pad0.69390178
64MP0005266_abnormal_metabolism0.64016407
65MP0002822_catalepsy0.63606771
66MP0002282_abnormal_trachea_morphology0.61703656
67MP0000639_abnormal_adrenal_gland0.59328504
68MP0005448_abnormal_energy_balance0.58249452
69MP0005646_abnormal_pituitary_gland0.56047191
70MP0001756_abnormal_urination0.55668451
71MP0009780_abnormal_chondrocyte_physiolo0.55457595
72MP0006035_abnormal_mitochondrial_morpho0.55050440
73MP0009053_abnormal_anal_canal0.51255291
74MP0005551_abnormal_eye_electrophysiolog0.50914230
75MP0003075_altered_response_to0.50192617
76MP0003638_abnormal_response/metabolism_0.50174697
77MP0002090_abnormal_vision0.49660770
78MP0002837_dystrophic_cardiac_calcinosis0.49207885
79MP0008874_decreased_physiological_sensi0.47724289
80MP0003172_abnormal_lysosome_physiology0.47437466
81MP0005248_abnormal_Harderian_gland0.45979345
82MP0005395_other_phenotype0.45184223
83MP0009384_cardiac_valve_regurgitation0.43572955
84MP0000920_abnormal_myelination0.43381729
85MP0003953_abnormal_hormone_level0.43350305
86MP0002928_abnormal_bile_duct0.42713463
87MP0002909_abnormal_adrenal_gland0.41636918
88MP0005464_abnormal_platelet_physiology0.41371126
89MP0005666_abnormal_adipose_tissue0.41283523
90MP0002136_abnormal_kidney_physiology0.41075255
91MP0003718_maternal_effect0.40577272
92MP0005166_decreased_susceptibility_to0.40193103
93MP0005164_abnormal_response_to0.39841640
94MP0004782_abnormal_surfactant_physiolog0.39807481
95MP0008872_abnormal_physiological_respon0.39196313
96MP0005167_abnormal_blood-brain_barrier0.38299730
97MP0003632_abnormal_nervous_system0.38044867
98MP0008873_increased_physiological_sensi0.37159197
99MP0000579_abnormal_nail_morphology0.36333066
100MP0000230_abnormal_systemic_arterial0.36043362
101MP0009672_abnormal_birth_weight0.35207915
102MP0009115_abnormal_fat_cell0.34150135
103MP0002269_muscular_atrophy0.33229114
104MP0000003_abnormal_adipose_tissue0.32646213
105MP0005595_abnormal_vascular_smooth0.32605701
106MP0001984_abnormal_olfaction0.32511818
107MP0001324_abnormal_eye_pigmentation0.31409577
108MP0005409_darkened_coat_color0.30842271
109MP0002168_other_aberrant_phenotype0.29970674
110MP0003633_abnormal_nervous_system0.29767986
111MP0000249_abnormal_blood_vessel0.29367916
112MP0001853_heart_inflammation0.28918999
113MP0003631_nervous_system_phenotype0.28304240
114MP0004883_abnormal_blood_vessel0.28204350
115MP0005023_abnormal_wound_healing0.27628474
116MP0002970_abnormal_white_adipose0.27163827
117MP0004272_abnormal_basement_membrane0.27103412
118MP0005377_hearing/vestibular/ear_phenot0.27034808
119MP0003878_abnormal_ear_physiology0.27034808
120MP0002796_impaired_skin_barrier0.26152882
121MP0003724_increased_susceptibility_to0.26102593
122MP0005330_cardiomyopathy0.25232311
123MP0003436_decreased_susceptibility_to0.24856381
124MP0001881_abnormal_mammary_gland0.24021119
125MP0004381_abnormal_hair_follicle0.23977443
126MP0005187_abnormal_penis_morphology0.23027497
127MP0004043_abnormal_pH_regulation0.23012391

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.37952623
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37873848
3Intrahepatic cholestasis (HP:0001406)7.20501343
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.55689240
5Prolonged partial thromboplastin time (HP:0003645)6.53557895
6Hypobetalipoproteinemia (HP:0003563)6.28194657
7Xanthomatosis (HP:0000991)6.26688151
8Hyperlipoproteinemia (HP:0010980)5.73089128
9Complement deficiency (HP:0004431)5.13850069
10Hypolipoproteinemia (HP:0010981)4.84040532
11Joint hemorrhage (HP:0005261)4.71674330
12Hyperammonemia (HP:0001987)4.65165755
13Hyperglycinemia (HP:0002154)4.53495863
14Epidermoid cyst (HP:0200040)4.44908041
15Abnormality of the common coagulation pathway (HP:0010990)4.40124751
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39402061
17Ketosis (HP:0001946)4.38757854
18Hypoalphalipoproteinemia (HP:0003233)4.38500779
19Abnormality of methionine metabolism (HP:0010901)4.24926517
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.23812452
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15646101
22Hyperglycinuria (HP:0003108)4.09595739
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08986123
24Abnormality of serine family amino acid metabolism (HP:0010894)4.07982875
25Abnormality of glycine metabolism (HP:0010895)4.07982875
26Fat malabsorption (HP:0002630)4.07439877
27Hypoglycemic coma (HP:0001325)3.92095635
28Abnormality of the intrinsic pathway (HP:0010989)3.70167523
29Abnormality of complement system (HP:0005339)3.68541632
30Conjugated hyperbilirubinemia (HP:0002908)3.66133447
31Abnormality of pyrimidine metabolism (HP:0004353)3.63362653
32Hypercholesterolemia (HP:0003124)3.62566339
33Nephritis (HP:0000123)3.40989653
34Abnormality of fatty-acid metabolism (HP:0004359)3.33123323
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31258995
36Hyperbilirubinemia (HP:0002904)3.29442080
37Delayed CNS myelination (HP:0002188)3.19237520
38Ketoacidosis (HP:0001993)3.17133298
39Steatorrhea (HP:0002570)3.10054380
40Abnormality of serum amino acid levels (HP:0003112)3.05263741
41Myocardial infarction (HP:0001658)2.99292645
42Abnormality of nucleobase metabolism (HP:0010932)2.98609330
43Spontaneous abortion (HP:0005268)2.98305411
44Purpura (HP:0000979)2.91705845
45Hepatocellular carcinoma (HP:0001402)2.88976183
46Hypochromic microcytic anemia (HP:0004840)2.82109919
47Skin nodule (HP:0200036)2.77832887
48Metabolic acidosis (HP:0001942)2.75495427
49Vascular calcification (HP:0004934)2.71152269
50Abnormality of purine metabolism (HP:0004352)2.66232669
51Hypoglycemic seizures (HP:0002173)2.58435448
52Dicarboxylic aciduria (HP:0003215)2.58305665
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58305665
54Lethargy (HP:0001254)2.58042483
55Systemic lupus erythematosus (HP:0002725)2.56279417
56Gout (HP:0001997)2.51707951
57Abnormality of the Achilles tendon (HP:0005109)2.51485472
58Abnormal gallbladder morphology (HP:0012437)2.50979628
59Osteomalacia (HP:0002749)2.48695250
60Mitral stenosis (HP:0001718)2.47996026
61Cholelithiasis (HP:0001081)2.45336708
62Cholecystitis (HP:0001082)2.43848573
63Abnormal gallbladder physiology (HP:0012438)2.43848573
64Cardiovascular calcification (HP:0011915)2.38919680
65Acanthocytosis (HP:0001927)2.37761473
66Spastic diplegia (HP:0001264)2.36364424
67Cerebral edema (HP:0002181)2.34871815
68Irritability (HP:0000737)2.33927719
69Pulmonary embolism (HP:0002204)2.33908642
70Glomerulonephritis (HP:0000099)2.33046464
71Amyloidosis (HP:0011034)2.31982395
72Neonatal onset (HP:0003623)2.31033311
73Bifid scrotum (HP:0000048)2.29232944
74Arthropathy (HP:0003040)2.28082453
75Malnutrition (HP:0004395)2.25264298
76Esophageal varix (HP:0002040)2.21725331
77Reduced antithrombin III activity (HP:0001976)2.20804506
78Sensorimotor neuropathy (HP:0007141)2.20608723
79Enlarged kidneys (HP:0000105)2.18929193
80Late onset (HP:0003584)2.16300327
81Hyperinsulinemic hypoglycemia (HP:0000825)2.14746082
82Brushfield spots (HP:0001088)2.08896471
83Gingival bleeding (HP:0000225)2.08507260
84Pancreatitis (HP:0001733)2.08008470
85Vomiting (HP:0002013)2.05771240
86Menorrhagia (HP:0000132)2.04519937
87Recurrent gram-negative bacterial infections (HP:0005420)2.02919684
88Abnormality of the gallbladder (HP:0005264)2.01845909
89Status epilepticus (HP:0002133)2.01376929
90Thrombophlebitis (HP:0004418)2.01227879
91Generalized aminoaciduria (HP:0002909)1.98548857
92Opisthotonus (HP:0002179)1.96782780
93Hydroxyprolinuria (HP:0003080)1.96119195
94Abnormality of proline metabolism (HP:0010907)1.96119195
95Hemorrhage of the eye (HP:0011885)1.95909555
96Poikilocytosis (HP:0004447)1.94325958
97Rickets (HP:0002748)1.92712533
98Fair hair (HP:0002286)1.92136878
99Hypophosphatemic rickets (HP:0004912)1.91823899
100Hyperphosphaturia (HP:0003109)1.84079405
101Alkalosis (HP:0001948)1.82848236
102Renal cortical cysts (HP:0000803)1.80268698
103Abnormality of iron homeostasis (HP:0011031)1.78173217
104Abnormality of transition element cation homeostasis (HP:0011030)1.76713639
105Elevated hepatic transaminases (HP:0002910)1.76396192
106Abnormal cartilage morphology (HP:0002763)1.75677542
107Gangrene (HP:0100758)1.75142300
108Reticulocytosis (HP:0001923)1.74737181
109Abnormality of vitamin metabolism (HP:0100508)1.72121016
110Hyperglycemia (HP:0003074)1.71890283
111Abnormal enzyme/coenzyme activity (HP:0012379)1.71475687
112Increased serum pyruvate (HP:0003542)1.70277039
113Abnormality of urine glucose concentration (HP:0011016)1.67504582
114Glycosuria (HP:0003076)1.67504582
115Back pain (HP:0003418)1.62289451
116Facial shape deformation (HP:0011334)1.61993053
117Potter facies (HP:0002009)1.61993053
118Elevated alkaline phosphatase (HP:0003155)1.57440169
119Abnormal urine phosphate concentration (HP:0012599)1.55202855
120Retinal atrophy (HP:0001105)1.55052969
121Epistaxis (HP:0000421)1.53465979
122Increased mean platelet volume (HP:0011877)1.50610912
123Increased serum ferritin (HP:0003281)1.49449389
124Abnormality of glycolysis (HP:0004366)1.48759210
125Atrioventricular block (HP:0001678)1.48495347
126Abnormality of alkaline phosphatase activity (HP:0004379)1.47108843
127Hypophosphatemia (HP:0002148)1.43416774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.92378580
2SIK14.84786381
3FGFR44.28639870
4ERN14.08744271
5INSRR3.20212351
6TAOK32.79328122
7ERBB42.59910733
8NTRK32.41377878
9MAP2K42.33863835
10PKN22.22043867
11WNK42.05982476
12TRIB32.05552447
13MST1R1.74675360
14MAPK111.73180839
15DAPK21.66458704
16PIK3CG1.62221163
17PINK11.60205880
18FLT31.58628138
19LATS11.55611209
20FGFR21.50168320
21PTK61.46254265
22EPHA41.37829334
23MAP3K71.37024544
24TIE11.35470934
25TYK21.35172860
26CDK121.28489577
27KDR1.28120576
28PRKAA21.27213949
29ABL21.19740230
30TYRO31.18194743
31MAPK121.15717333
32FRK1.14756082
33FGFR11.13790035
34GRK11.11660051
35JAK21.10021980
36NEK91.07880022
37ERBB21.04422817
38CAMK1D1.01544302
39PRKCZ1.00615315
40SGK10.99955440
41PDGFRA0.99954037
42MAP3K20.98643245
43MAPK150.96750666
44STK38L0.95149811
45MAPK40.91330397
46SIK20.90043113
47JAK10.90017085
48GRK60.89049176
49MAPKAPK30.86956304
50SGK30.83872262
51PRKG10.83757083
52PRKACG0.83081360
53RIPK10.83054016
54PRKAA10.82245335
55MAPK70.80363694
56MAP2K30.78781056
57NTRK20.78716791
58TBK10.75271839
59EPHB10.75165000
60SGK20.72279397
61CAMK2G0.70188072
62EPHA30.68755598
63CSNK1D0.68208612
64WNK10.67184143
65PRKACA0.67016408
66PBK0.66690224
67MET0.66112910
68DYRK1B0.65896907
69MAP3K100.65252294
70CASK0.64982075
71RPS6KA30.64404273
72MAP3K30.64096110
73MAP3K140.63502969
74AKT30.63405959
75TAOK20.62979853
76RPS6KB10.62836433
77MAP2K60.62494330
78CAMK1G0.62463103
79SGK4940.62444253
80SGK2230.62444253
81GSK3A0.60417814
82IRAK30.60341817
83KSR20.60298097
84CDK60.58702526
85PRKCG0.58604520
86MAP3K10.57744460
87CSK0.57713754
88FGFR30.57048692
89PDPK10.55024937
90EEF2K0.54465098
91PRPF4B0.53219520
92ICK0.49382514
93PHKG20.49255936
94PHKG10.49255936
95PTK20.48974542
96CSNK1E0.48775768
97PRKCQ0.48129566
98MAP3K110.47623741
99PKN10.47301932
100RET0.46662718
101AKT20.46053351
102IGF1R0.45758305
103DDR20.45468018
104PDK20.44823161
105IRAK20.43907539
106MAP3K130.43741628
107CAMK40.42132598
108MAP2K10.40963164
109TGFBR20.39860315
110PRKCB0.38669979
111MAPK100.38360507
112SRC0.36810918
113MARK10.35323013
114PAK30.35273723
115MAP3K50.34921446
116CSNK1G10.34369457
117STK380.34008904
118MAP3K40.33849445
119PRKCA0.33714877
120MTOR0.33463994
121PDK10.33268867
122BMX0.32438323
123CSF1R0.31493647
124PIK3CA0.31301491
125PRKACB0.30438922
126CAMKK10.30418830
127CSNK1A10.29906403
128IRAK10.28248346
129NLK0.28078403
130OBSCN0.28046729
131MAP3K60.27943345
132CSNK2A20.27770904
133MARK20.27710308
134EGFR0.27705597
135STK160.27523024
136PDK40.27039718
137PDK30.27039718

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40174892
2Nitrogen metabolism_Homo sapiens_hsa009103.82099703
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38178906
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30554954
5Arginine biosynthesis_Homo sapiens_hsa002203.10259937
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.78843536
7Complement and coagulation cascades_Homo sapiens_hsa046102.68735009
8Tryptophan metabolism_Homo sapiens_hsa003802.64390703
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61475006
10Fatty acid degradation_Homo sapiens_hsa000712.53571532
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51983434
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41145660
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20461982
14Butanoate metabolism_Homo sapiens_hsa006502.18238995
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08547322
16Peroxisome_Homo sapiens_hsa041462.05244997
17Propanoate metabolism_Homo sapiens_hsa006401.97544820
18Chemical carcinogenesis_Homo sapiens_hsa052041.90159162
19PPAR signaling pathway_Homo sapiens_hsa033201.90152577
20Fatty acid metabolism_Homo sapiens_hsa012121.89118688
21Histidine metabolism_Homo sapiens_hsa003401.87990682
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.87056017
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86180299
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78584073
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.70112592
26Retinol metabolism_Homo sapiens_hsa008301.68988417
27beta-Alanine metabolism_Homo sapiens_hsa004101.68604583
28Staphylococcus aureus infection_Homo sapiens_hsa051501.67769682
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67066759
30Caffeine metabolism_Homo sapiens_hsa002321.64501227
31Bile secretion_Homo sapiens_hsa049761.59134127
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58845314
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58525414
34Selenocompound metabolism_Homo sapiens_hsa004501.51364269
35Phenylalanine metabolism_Homo sapiens_hsa003601.51276863
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44214277
37Tyrosine metabolism_Homo sapiens_hsa003501.39477450
38Pyruvate metabolism_Homo sapiens_hsa006201.36941004
39Fatty acid elongation_Homo sapiens_hsa000621.33476453
40Starch and sucrose metabolism_Homo sapiens_hsa005001.29575685
41Sulfur metabolism_Homo sapiens_hsa009201.29224198
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.27815728
43Steroid biosynthesis_Homo sapiens_hsa001001.24185268
44Biosynthesis of amino acids_Homo sapiens_hsa012301.23730308
45ABC transporters_Homo sapiens_hsa020101.23544635
46Fat digestion and absorption_Homo sapiens_hsa049751.19007519
47Carbon metabolism_Homo sapiens_hsa012001.13768105
48Folate biosynthesis_Homo sapiens_hsa007901.12367536
49Arginine and proline metabolism_Homo sapiens_hsa003301.01210445
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00509220
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.99678476
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.98390750
53Vitamin B6 metabolism_Homo sapiens_hsa007500.90202465
54Sulfur relay system_Homo sapiens_hsa041220.88513025
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88388827
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87703232
57Lysine degradation_Homo sapiens_hsa003100.82358932
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82150883
59Glycerolipid metabolism_Homo sapiens_hsa005610.74292389
60* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73844983
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73072594
62Fatty acid biosynthesis_Homo sapiens_hsa000610.69465504
63One carbon pool by folate_Homo sapiens_hsa006700.65725488
64Glutathione metabolism_Homo sapiens_hsa004800.57336159
65Pentose phosphate pathway_Homo sapiens_hsa000300.55156020
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51264149
67Metabolic pathways_Homo sapiens_hsa011000.44879271
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35762001
69Fructose and mannose metabolism_Homo sapiens_hsa000510.30817297
70Pertussis_Homo sapiens_hsa051330.30600713
71Prion diseases_Homo sapiens_hsa050200.30382388
72Other glycan degradation_Homo sapiens_hsa005110.28406513
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28266680
74Galactose metabolism_Homo sapiens_hsa000520.27599009
75Insulin resistance_Homo sapiens_hsa049310.26327742
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.26018629
77Linoleic acid metabolism_Homo sapiens_hsa005910.20933431
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.20483777
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18525896
80Glucagon signaling pathway_Homo sapiens_hsa049220.15432745
81AMPK signaling pathway_Homo sapiens_hsa041520.04998039
82Mineral absorption_Homo sapiens_hsa049780.01400962
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01250320
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2236886
85Renin-angiotensin system_Homo sapiens_hsa04614-0.2214537
86Protein digestion and absorption_Homo sapiens_hsa04974-0.2213486
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2188650
88Phototransduction_Homo sapiens_hsa04744-0.2101639
89Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2044923
90Hepatitis C_Homo sapiens_hsa05160-0.2023422
91Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1980017
92Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1917402
93Type II diabetes mellitus_Homo sapiens_hsa04930-0.1726138
94Circadian rhythm_Homo sapiens_hsa04710-0.1705693
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1670811
96Regulation of autophagy_Homo sapiens_hsa04140-0.1666968
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1507736
98African trypanosomiasis_Homo sapiens_hsa05143-0.1490790
99Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1485986
100Amoebiasis_Homo sapiens_hsa05146-0.1421729
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1402088
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1280749
103Serotonergic synapse_Homo sapiens_hsa04726-0.1187308
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1153651
105N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1061169
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0762521
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0704481
108Sphingolipid metabolism_Homo sapiens_hsa00600-0.0662378
109Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0650687
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0306043

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »