SLC35G5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.89114031
2response to pheromone (GO:0019236)5.16778675
3regulation of meiosis I (GO:0060631)5.04137336
4DNA deamination (GO:0045006)4.45709347
5piRNA metabolic process (GO:0034587)4.34899548
6DNA methylation involved in gamete generation (GO:0043046)4.30392353
7protein polyglutamylation (GO:0018095)4.16577140
8positive regulation of meiosis (GO:0045836)4.00696497
9sphingosine metabolic process (GO:0006670)3.82088512
10indolalkylamine metabolic process (GO:0006586)3.81865038
11positive regulation of meiotic cell cycle (GO:0051446)3.74686761
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70073222
13centriole replication (GO:0007099)3.65392543
14sperm motility (GO:0030317)3.55110256
15tryptophan catabolic process (GO:0006569)3.48499748
16indole-containing compound catabolic process (GO:0042436)3.48499748
17indolalkylamine catabolic process (GO:0046218)3.48499748
18diol metabolic process (GO:0034311)3.46325938
19sphingoid metabolic process (GO:0046519)3.45929868
20male meiosis I (GO:0007141)3.35949383
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29025657
22kynurenine metabolic process (GO:0070189)3.22094818
23postsynaptic membrane organization (GO:0001941)3.16435197
24acrosome reaction (GO:0007340)3.16126067
25cellular ketone body metabolic process (GO:0046950)3.14939701
26axoneme assembly (GO:0035082)3.10546701
27axonemal dynein complex assembly (GO:0070286)3.08460191
28negative regulation of telomere maintenance (GO:0032205)3.06880931
29water-soluble vitamin biosynthetic process (GO:0042364)3.06559413
30negative regulation of mast cell activation (GO:0033004)3.02237436
31tachykinin receptor signaling pathway (GO:0007217)2.99888681
32regulation of rhodopsin mediated signaling pathway (GO:0022400)2.96766972
33regulation of hexokinase activity (GO:1903299)2.95656965
34regulation of glucokinase activity (GO:0033131)2.95656965
35reciprocal meiotic recombination (GO:0007131)2.92464123
36reciprocal DNA recombination (GO:0035825)2.92464123
37gamma-aminobutyric acid transport (GO:0015812)2.92057734
38regulation of cilium movement (GO:0003352)2.91784314
39indole-containing compound metabolic process (GO:0042430)2.90746301
40primary amino compound metabolic process (GO:1901160)2.90295137
41spermatid development (GO:0007286)2.89207562
42amine catabolic process (GO:0009310)2.87569549
43cellular biogenic amine catabolic process (GO:0042402)2.87569549
44detection of light stimulus involved in sensory perception (GO:0050962)2.87391318
45detection of light stimulus involved in visual perception (GO:0050908)2.87391318
46epithelial cilium movement (GO:0003351)2.87187573
47inositol phosphate catabolic process (GO:0071545)2.83993866
48ketone body metabolic process (GO:1902224)2.83543713
49transmission of nerve impulse (GO:0019226)2.80312664
50sequestering of actin monomers (GO:0042989)2.78655156
51rhodopsin mediated signaling pathway (GO:0016056)2.75751144
52establishment of protein localization to mitochondrial membrane (GO:0090151)2.74970220
53tryptophan metabolic process (GO:0006568)2.74545716
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71918779
55phosphorylated carbohydrate dephosphorylation (GO:0046838)2.70909741
56inositol phosphate dephosphorylation (GO:0046855)2.70909741
57sulfate transmembrane transport (GO:1902358)2.70619418
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70366013
59sulfation (GO:0051923)2.69182553
60serotonin metabolic process (GO:0042428)2.68979026
61meiotic chromosome segregation (GO:0045132)2.67694825
62protein localization to cilium (GO:0061512)2.65268420
63single strand break repair (GO:0000012)2.64860733
64peristalsis (GO:0030432)2.64606403
65regulation of collateral sprouting (GO:0048670)2.63289067
66kidney morphogenesis (GO:0060993)2.63200775
67regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.62813300
68positive regulation of oligodendrocyte differentiation (GO:0048714)2.60131071
69synaptic transmission, cholinergic (GO:0007271)2.58116236
70regulation of microtubule-based movement (GO:0060632)2.58111382
71nonmotile primary cilium assembly (GO:0035058)2.57904749
72polyol catabolic process (GO:0046174)2.57849012
73preassembly of GPI anchor in ER membrane (GO:0016254)2.56921556
74cellular response to ATP (GO:0071318)2.56490721
75neuronal action potential (GO:0019228)2.56281008
76cornea development in camera-type eye (GO:0061303)2.52538288
77neural tube formation (GO:0001841)2.51661210
78multicellular organism reproduction (GO:0032504)2.51607556
79protein localization to synapse (GO:0035418)2.50461257
80cellular biogenic amine biosynthetic process (GO:0042401)2.49233682
81spinal cord motor neuron differentiation (GO:0021522)2.49197143
82centriole assembly (GO:0098534)2.49110661
83sulfate transport (GO:0008272)2.48678233
84photoreceptor cell maintenance (GO:0045494)2.46595436
85iron coordination entity transport (GO:1901678)2.46575972
86pyrimidine nucleobase catabolic process (GO:0006208)2.46288572
87cell proliferation in forebrain (GO:0021846)2.45719554
88ubiquinone biosynthetic process (GO:0006744)2.44470425
89regulation of neurotransmitter uptake (GO:0051580)2.43076573
90male meiosis (GO:0007140)2.42912355
91replication fork processing (GO:0031297)2.42494939
92aspartate family amino acid catabolic process (GO:0009068)2.41179069
93amine biosynthetic process (GO:0009309)2.40922984
94L-fucose catabolic process (GO:0042355)2.40494814
95fucose catabolic process (GO:0019317)2.40494814
96L-fucose metabolic process (GO:0042354)2.40494814
97calcium ion-dependent exocytosis (GO:0017156)2.40412423
98cilium movement (GO:0003341)2.40297720
99motile cilium assembly (GO:0044458)2.37877855
100cilium organization (GO:0044782)2.37691303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66982940
2ZNF274_21170338_ChIP-Seq_K562_Hela3.46943728
3VDR_22108803_ChIP-Seq_LS180_Human3.24477045
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79549774
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40019359
6GBX2_23144817_ChIP-Seq_PC3_Human2.22456464
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21602770
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12049332
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10693184
10CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95626238
11FUS_26573619_Chip-Seq_HEK293_Human1.91590233
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91235695
13ER_23166858_ChIP-Seq_MCF-7_Human1.89181586
14P300_19829295_ChIP-Seq_ESCs_Human1.89131145
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88292353
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82047391
17REST_21632747_ChIP-Seq_MESCs_Mouse1.80819187
18AR_21572438_ChIP-Seq_LNCaP_Human1.78015643
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77655269
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77655269
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76601853
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.60569424
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57343919
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55059727
25BCAT_22108803_ChIP-Seq_LS180_Human1.47801320
26RNF2_27304074_Chip-Seq_NSC_Mouse1.47093739
27CBP_20019798_ChIP-Seq_JUKART_Human1.45410576
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45410576
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43951100
30EWS_26573619_Chip-Seq_HEK293_Human1.43085614
31TP53_22573176_ChIP-Seq_HFKS_Human1.42744207
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42271673
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39912741
34GATA3_21878914_ChIP-Seq_MCF-7_Human1.38121057
35IGF1R_20145208_ChIP-Seq_DFB_Human1.37951930
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37004903
37STAT3_23295773_ChIP-Seq_U87_Human1.36598631
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.35345198
39TCF4_23295773_ChIP-Seq_U87_Human1.35212647
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34779528
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.34353142
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34316357
43TAF15_26573619_Chip-Seq_HEK293_Human1.33066795
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.32833482
45TAF2_19829295_ChIP-Seq_ESCs_Human1.32329494
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31535417
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.30268176
48NCOR_22424771_ChIP-Seq_293T_Human1.28973242
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28188250
50SMAD4_21799915_ChIP-Seq_A2780_Human1.28155961
51NANOG_19829295_ChIP-Seq_ESCs_Human1.27562051
52SOX2_19829295_ChIP-Seq_ESCs_Human1.27562051
53AR_25329375_ChIP-Seq_VCAP_Human1.26751555
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26645163
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25523978
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25489696
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25356008
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.24485465
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.24365750
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23627595
61NANOG_20526341_ChIP-Seq_ESCs_Human1.23214947
62HOXB7_26014856_ChIP-Seq_BT474_Human1.22961525
63ERA_21632823_ChIP-Seq_H3396_Human1.22778027
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22482660
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21772270
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.20267616
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.20040268
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20040268
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18693264
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.18433010
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18088499
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.17547553
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.17351436
74DROSHA_22980978_ChIP-Seq_HELA_Human1.16589049
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16493139
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16416397
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15940586
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15021219
79RUNX2_22187159_ChIP-Seq_PCA_Human1.14727320
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14708018
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.11722803
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11501882
83IRF1_19129219_ChIP-ChIP_H3396_Human1.10414227
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09316547
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06859214
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.05002523
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04019333
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03361233
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.03324157
90MYC_19829295_ChIP-Seq_ESCs_Human1.03229398
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.02854161
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02613371
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01312554
94OCT4_20526341_ChIP-Seq_ESCs_Human1.00580164
95TCF4_22108803_ChIP-Seq_LS180_Human1.00039907
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.99946803
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99945237
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97906256
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97700012
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.97329739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.12275582
2MP0003646_muscle_fatigue3.19562904
3MP0003136_yellow_coat_color3.06442245
4MP0000569_abnormal_digit_pigmentation2.92033661
5MP0005171_absent_coat_pigmentation2.88295479
6MP0002653_abnormal_ependyma_morphology2.87172222
7MP0001348_abnormal_lacrimal_gland2.54332713
8MP0008877_abnormal_DNA_methylation2.52648488
9MP0001968_abnormal_touch/_nociception2.37967248
10MP0006276_abnormal_autonomic_nervous2.28581446
11MP0005551_abnormal_eye_electrophysiolog2.08614449
12MP0005174_abnormal_tail_pigmentation2.07302257
13MP0005410_abnormal_fertilization2.07135772
14MP0002160_abnormal_reproductive_system2.06794233
15MP0008872_abnormal_physiological_respon2.01014127
16MP0004885_abnormal_endolymph1.98805563
17MP0002735_abnormal_chemical_nociception1.95349450
18MP0003195_calcinosis1.91623014
19MP0003787_abnormal_imprinting1.87797581
20MP0004142_abnormal_muscle_tone1.84002830
21MP0003890_abnormal_embryonic-extraembry1.80282699
22MP0005075_abnormal_melanosome_morpholog1.77156469
23MP0009046_muscle_twitch1.71188275
24MP0002736_abnormal_nociception_after1.70101730
25MP0006292_abnormal_olfactory_placode1.68697679
26MP0009745_abnormal_behavioral_response1.68307194
27MP0002102_abnormal_ear_morphology1.67782471
28MP0003880_abnormal_central_pattern1.62629487
29MP0002272_abnormal_nervous_system1.61404098
30MP0001501_abnormal_sleep_pattern1.59152563
31MP0004742_abnormal_vestibular_system1.55176116
32MP0002733_abnormal_thermal_nociception1.54969117
33MP0005377_hearing/vestibular/ear_phenot1.53763359
34MP0003878_abnormal_ear_physiology1.53763359
35MP0001970_abnormal_pain_threshold1.52369588
36MP0005389_reproductive_system_phenotype1.50143338
37MP0001986_abnormal_taste_sensitivity1.47874658
38MP0001440_abnormal_grooming_behavior1.47410960
39MP0005423_abnormal_somatic_nervous1.41607612
40MP0005379_endocrine/exocrine_gland_phen1.40956411
41MP0005646_abnormal_pituitary_gland1.40407154
42MP0000015_abnormal_ear_pigmentation1.38037784
43MP0003879_abnormal_hair_cell1.37964912
44MP0002138_abnormal_hepatobiliary_system1.37274645
45MP0002163_abnormal_gland_morphology1.36925701
46MP0000427_abnormal_hair_cycle1.35194888
47MP0001486_abnormal_startle_reflex1.33063369
48MP0002572_abnormal_emotion/affect_behav1.29772069
49MP0005253_abnormal_eye_physiology1.28562238
50MP0006072_abnormal_retinal_apoptosis1.27767364
51MP0001984_abnormal_olfaction1.26563355
52MP0010386_abnormal_urinary_bladder1.21086036
53MP0003011_delayed_dark_adaptation1.21005779
54MP0003635_abnormal_synaptic_transmissio1.18746835
55MP0000778_abnormal_nervous_system1.18504612
56MP0000372_irregular_coat_pigmentation1.18344435
57MP0002095_abnormal_skin_pigmentation1.17685237
58MP0004043_abnormal_pH_regulation1.16771383
59MP0002734_abnormal_mechanical_nocicepti1.16599102
60MP0002938_white_spotting1.15511488
61MP0001905_abnormal_dopamine_level1.15289323
62MP0002067_abnormal_sensory_capabilities1.14707197
63MP0002557_abnormal_social/conspecific_i1.14068893
64MP0005670_abnormal_white_adipose1.13665961
65MP0003698_abnormal_male_reproductive1.12998625
66MP0003718_maternal_effect1.10906209
67MP0002928_abnormal_bile_duct1.10311424
68MP0002638_abnormal_pupillary_reflex1.09475455
69MP0004133_heterotaxia1.05845831
70MP0002063_abnormal_learning/memory/cond1.04425519
71MP0004147_increased_porphyrin_level1.03572328
72MP0001929_abnormal_gametogenesis1.02582096
73MP0001485_abnormal_pinna_reflex1.02052595
74MP0002064_seizures1.01211778
75MP0004381_abnormal_hair_follicle1.00715646
76MP0002210_abnormal_sex_determination1.00697051
77MP0008995_early_reproductive_senescence0.99910153
78MP0005645_abnormal_hypothalamus_physiol0.92548004
79MP0003283_abnormal_digestive_organ0.88450140
80MP0005167_abnormal_blood-brain_barrier0.88433730
81MP0002751_abnormal_autonomic_nervous0.87128792
82MP0003121_genomic_imprinting0.86695179
83MP0003137_abnormal_impulse_conducting0.86651472
84MP0005386_behavior/neurological_phenoty0.85745858
85MP0004924_abnormal_behavior0.85745858
86MP0001919_abnormal_reproductive_system0.83807324
87MP0002909_abnormal_adrenal_gland0.83538419
88MP0003045_fibrosis0.83270232
89MP0005448_abnormal_energy_balance0.81746865
90MP0000026_abnormal_inner_ear0.81537862
91MP0005195_abnormal_posterior_eye0.81180852
92MP0002876_abnormal_thyroid_physiology0.80323978
93MP0002184_abnormal_innervation0.79372652
94MP0001963_abnormal_hearing_physiology0.78493034
95MP0002229_neurodegeneration0.77771327
96MP0000653_abnormal_sex_gland0.77718071
97MP0002752_abnormal_somatic_nervous0.75857018
98MP0003119_abnormal_digestive_system0.75548612
99MP0008875_abnormal_xenobiotic_pharmacok0.75532373
100MP0001145_abnormal_male_reproductive0.75365328

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.81142731
2Pancreatic cysts (HP:0001737)4.43097413
3Pancreatic fibrosis (HP:0100732)4.26071158
4Abnormality of midbrain morphology (HP:0002418)4.13854989
5Molar tooth sign on MRI (HP:0002419)4.13854989
6Chronic hepatic failure (HP:0100626)3.98570632
7Severe visual impairment (HP:0001141)3.89377258
8Stomach cancer (HP:0012126)3.85026506
9True hermaphroditism (HP:0010459)3.81186611
10Nephronophthisis (HP:0000090)3.75504372
11Abnormality of the renal cortex (HP:0011035)3.69872276
12Abnormality of the renal medulla (HP:0100957)3.47429747
13Pendular nystagmus (HP:0012043)3.28403830
14Abnormal rod and cone electroretinograms (HP:0008323)3.18271087
15Focal motor seizures (HP:0011153)3.15371367
16Attenuation of retinal blood vessels (HP:0007843)3.06060871
17Cystic liver disease (HP:0006706)2.96653101
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.87236287
19Absent/shortened dynein arms (HP:0200106)2.87236287
20Polydipsia (HP:0001959)2.82745723
21Abnormal drinking behavior (HP:0030082)2.82745723
22Decreased central vision (HP:0007663)2.73545816
23Anencephaly (HP:0002323)2.72662364
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69788144
25Tubular atrophy (HP:0000092)2.61657927
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61342088
27Medial flaring of the eyebrow (HP:0010747)2.61197844
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54237093
29Bony spicule pigmentary retinopathy (HP:0007737)2.50715885
30Sclerocornea (HP:0000647)2.48497343
31Polyuria (HP:0000103)2.47517373
32Gaze-evoked nystagmus (HP:0000640)2.47269105
33Hyperventilation (HP:0002883)2.46841083
34Abolished electroretinogram (ERG) (HP:0000550)2.44760421
35Amelogenesis imperfecta (HP:0000705)2.39511132
36Type II lissencephaly (HP:0007260)2.35621046
37Congenital hepatic fibrosis (HP:0002612)2.35031552
38Colon cancer (HP:0003003)2.32984713
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30203671
40Renal cortical cysts (HP:0000803)2.24238600
41Abnormal ciliary motility (HP:0012262)2.23523641
42Abnormal respiratory epithelium morphology (HP:0012253)2.19925167
43Abnormal respiratory motile cilium morphology (HP:0005938)2.19925167
44Focal seizures (HP:0007359)2.17053663
45Chorioretinal atrophy (HP:0000533)2.16378776
46Asplenia (HP:0001746)2.14730686
47Abnormal respiratory motile cilium physiology (HP:0012261)2.14202661
48Abnormality of macular pigmentation (HP:0008002)2.14061249
49Broad-based gait (HP:0002136)2.13242130
50Furrowed tongue (HP:0000221)2.11868299
51Gait imbalance (HP:0002141)2.11217449
52Progressive cerebellar ataxia (HP:0002073)2.10602325
53Increased corneal curvature (HP:0100692)2.10387805
54Keratoconus (HP:0000563)2.10387805
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.08511245
56Postaxial foot polydactyly (HP:0001830)2.08368892
57Lissencephaly (HP:0001339)2.07868593
58Bile duct proliferation (HP:0001408)2.05407464
59Abnormal biliary tract physiology (HP:0012439)2.05407464
60Nephrogenic diabetes insipidus (HP:0009806)2.02374199
61Abnormal urine output (HP:0012590)2.01829281
62Retinitis pigmentosa (HP:0000510)1.99130052
63Tubulointerstitial fibrosis (HP:0005576)1.98896186
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.95738585
65Congenital primary aphakia (HP:0007707)1.94179812
66Failure to thrive in infancy (HP:0001531)1.94131345
67Macular degeneration (HP:0000608)1.93985729
68Hypoalbuminemia (HP:0003073)1.93211113
69Abnormal albumin level (HP:0012116)1.93211113
70Dialeptic seizures (HP:0011146)1.92987321
71Aplasia/Hypoplasia of the uvula (HP:0010293)1.91694588
72IgG deficiency (HP:0004315)1.89413361
73Abnormality of renal excretion (HP:0011036)1.89215146
74Absent thumb (HP:0009777)1.88043037
75Male pseudohermaphroditism (HP:0000037)1.87870329
76Occipital encephalocele (HP:0002085)1.82702129
77Recurrent sinusitis (HP:0011108)1.82524150
78Volvulus (HP:0002580)1.79289976
79Cerebellar dysplasia (HP:0007033)1.78029484
80Glycosuria (HP:0003076)1.77570105
81Abnormality of urine glucose concentration (HP:0011016)1.77570105
82Febrile seizures (HP:0002373)1.77262659
83Abnormality of the renal collecting system (HP:0004742)1.76894306
84Rhinitis (HP:0012384)1.76681009
85Optic disc pallor (HP:0000543)1.72735191
86Decreased circulating renin level (HP:0003351)1.72412009
87Thyroiditis (HP:0100646)1.71858330
88Vaginal atresia (HP:0000148)1.71504456
89Retinal dysplasia (HP:0007973)1.71259932
90Methylmalonic acidemia (HP:0002912)1.70776844
91Progressive macrocephaly (HP:0004481)1.70612595
92Abnormality of DNA repair (HP:0003254)1.69288478
93Genital tract atresia (HP:0001827)1.68670776
94Neoplasm of the adrenal cortex (HP:0100641)1.67589579
95Pachygyria (HP:0001302)1.67263850
96Inability to walk (HP:0002540)1.65754189
97Erythroderma (HP:0001019)1.65704909
98Elevated erythrocyte sedimentation rate (HP:0003565)1.65656551
99Limb dystonia (HP:0002451)1.65060166
100Optic nerve hypoplasia (HP:0000609)1.63245584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.28880751
2PINK13.29024428
3TAOK33.01681238
4STK38L2.97103854
5WNK42.85000772
6MAP4K22.67632767
7ADRBK22.66790560
8CASK2.50849092
9LATS12.47310646
10BMPR1B2.37141642
11ACVR1B2.26749867
12ZAK2.22558150
13TRIM282.06325072
14PDK22.02629481
15PNCK1.82617900
16WNK31.75887574
17GRK11.74073861
18CAMKK21.63566612
19MAPK131.57355234
20NEK21.55556932
21INSRR1.51187726
22DAPK21.46834615
23MAPKAPK31.34154471
24STK391.33909831
25NTRK31.30662483
26PLK21.29959241
27STK161.29879079
28MUSK1.19154492
29STK381.19054107
30NUAK11.18730444
31PLK41.13318712
32TLK11.12550462
33CAMK1G1.11968573
34SIK21.06861104
35CAMKK11.02237090
36ADRBK11.00431223
37TXK0.99122983
38NLK0.98243263
39OXSR10.94562106
40DYRK20.94386624
41MAPK150.92118331
42TNIK0.88362276
43LATS20.87089556
44GRK70.86685646
45NME10.84843811
46MKNK20.84706551
47PAK30.84023106
48PASK0.82622843
49STK30.81643378
50CAMK10.81007534
51PRKCG0.80974449
52MAP3K40.76987240
53WNK10.76363626
54MARK10.74443147
55PRKAA20.73763367
56TAF10.72581355
57IRAK40.70624435
58PKN10.69845034
59PTK2B0.68726383
60NTRK20.64537160
61IKBKE0.62293646
62CAMK1D0.61578644
63PRKCE0.61016714
64FGFR20.60964987
65STK110.60020271
66PRKD30.58586078
67TNK20.58022610
68MAP3K20.57792536
69PRKCQ0.56993187
70ERBB30.54824671
71MAP2K20.52296608
72PIK3CG0.46886744
73PRKACA0.46352153
74CSNK1G20.45911748
75KDR0.45504337
76IKBKB0.45048781
77PRKAA10.44915813
78BRSK20.44367604
79PRKCH0.44058511
80CAMK40.41684011
81CAMK2A0.40039371
82PRKCI0.39619341
83MAP2K70.39401872
84TRPM70.38163855
85PLK10.37909846
86DYRK1A0.36713380
87TGFBR10.33023305
88GRK60.31700473
89GRK50.30665640
90DYRK30.29437046
91PHKG20.29067839
92PHKG10.29067839
93PRKCA0.28480746
94CDK30.28063928
95MAPKAPK50.28054024
96ITK0.27993481
97FER0.27736649
98MARK30.27320093
99SYK0.26717571
100PRKCZ0.25248910

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.65524039
2Phototransduction_Homo sapiens_hsa047443.27858734
3Nicotine addiction_Homo sapiens_hsa050332.67416495
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49622679
5Nitrogen metabolism_Homo sapiens_hsa009102.32993225
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.32593504
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.30813221
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23488050
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18532669
10Linoleic acid metabolism_Homo sapiens_hsa005912.14917487
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11694431
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.10337312
13Oxidative phosphorylation_Homo sapiens_hsa001901.96612229
14Taste transduction_Homo sapiens_hsa047421.91559043
15Homologous recombination_Homo sapiens_hsa034401.88556411
16Butanoate metabolism_Homo sapiens_hsa006501.87346068
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65425672
18RNA polymerase_Homo sapiens_hsa030201.61287885
19Olfactory transduction_Homo sapiens_hsa047401.59961659
20Tryptophan metabolism_Homo sapiens_hsa003801.59418641
21Morphine addiction_Homo sapiens_hsa050321.53314673
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49992480
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48988943
24Histidine metabolism_Homo sapiens_hsa003401.47637310
25Dorso-ventral axis formation_Homo sapiens_hsa043201.45841187
26Ether lipid metabolism_Homo sapiens_hsa005651.45508337
27Fanconi anemia pathway_Homo sapiens_hsa034601.41921109
28Parkinsons disease_Homo sapiens_hsa050121.34820566
29Protein export_Homo sapiens_hsa030601.32958763
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19791882
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19528665
32Caffeine metabolism_Homo sapiens_hsa002321.15929455
33Primary immunodeficiency_Homo sapiens_hsa053401.15229321
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.10700093
35Basal transcription factors_Homo sapiens_hsa030221.10433422
36GABAergic synapse_Homo sapiens_hsa047271.08796932
37Glutamatergic synapse_Homo sapiens_hsa047241.08024967
38Retinol metabolism_Homo sapiens_hsa008301.06748076
39Cardiac muscle contraction_Homo sapiens_hsa042601.06605356
40Peroxisome_Homo sapiens_hsa041461.03997343
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03422587
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01750863
43Chemical carcinogenesis_Homo sapiens_hsa052041.01549645
44Alzheimers disease_Homo sapiens_hsa050101.00448082
45Regulation of autophagy_Homo sapiens_hsa041400.99671335
46Selenocompound metabolism_Homo sapiens_hsa004500.98449659
47Huntingtons disease_Homo sapiens_hsa050160.97066324
48Calcium signaling pathway_Homo sapiens_hsa040200.97030797
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96328515
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.93826778
51Asthma_Homo sapiens_hsa053100.93795166
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92871042
53Arachidonic acid metabolism_Homo sapiens_hsa005900.90315295
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90233991
55Insulin secretion_Homo sapiens_hsa049110.89617007
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.88910492
57Sphingolipid metabolism_Homo sapiens_hsa006000.86752554
58Circadian entrainment_Homo sapiens_hsa047130.86565269
59ABC transporters_Homo sapiens_hsa020100.84218220
60Serotonergic synapse_Homo sapiens_hsa047260.83202243
61RNA degradation_Homo sapiens_hsa030180.77748536
62Salivary secretion_Homo sapiens_hsa049700.77320478
63Ovarian steroidogenesis_Homo sapiens_hsa049130.76647118
64Glycerolipid metabolism_Homo sapiens_hsa005610.75518547
65Fat digestion and absorption_Homo sapiens_hsa049750.74796074
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73769127
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72854930
68Fatty acid biosynthesis_Homo sapiens_hsa000610.68921578
69Collecting duct acid secretion_Homo sapiens_hsa049660.68106159
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64482577
71Vitamin digestion and absorption_Homo sapiens_hsa049770.60665161
72Cholinergic synapse_Homo sapiens_hsa047250.55041049
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53869386
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53861158
75Metabolic pathways_Homo sapiens_hsa011000.52735364
76Hedgehog signaling pathway_Homo sapiens_hsa043400.50718942
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.49841496
78Allograft rejection_Homo sapiens_hsa053300.49697985
79Dopaminergic synapse_Homo sapiens_hsa047280.49131794
80cAMP signaling pathway_Homo sapiens_hsa040240.48892529
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48653581
82Propanoate metabolism_Homo sapiens_hsa006400.48407851
83Oxytocin signaling pathway_Homo sapiens_hsa049210.48074454
84Sulfur relay system_Homo sapiens_hsa041220.47037564
85Hematopoietic cell lineage_Homo sapiens_hsa046400.45353433
86Fatty acid degradation_Homo sapiens_hsa000710.41882122
87Pancreatic secretion_Homo sapiens_hsa049720.41022160
88beta-Alanine metabolism_Homo sapiens_hsa004100.40799872
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37414863
90Autoimmune thyroid disease_Homo sapiens_hsa053200.34697886
91Type I diabetes mellitus_Homo sapiens_hsa049400.34610481
92Synaptic vesicle cycle_Homo sapiens_hsa047210.34383946
93Tyrosine metabolism_Homo sapiens_hsa003500.32814464
94Non-homologous end-joining_Homo sapiens_hsa034500.31394729
95Type II diabetes mellitus_Homo sapiens_hsa049300.30187005
96Ribosome_Homo sapiens_hsa030100.30179839
97Amphetamine addiction_Homo sapiens_hsa050310.29202120
98Purine metabolism_Homo sapiens_hsa002300.28784918
99Graft-versus-host disease_Homo sapiens_hsa053320.28738117
100Pyrimidine metabolism_Homo sapiens_hsa002400.27751708

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