SLC35F6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.49981247
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.49981247
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.49981247
4modulation by symbiont of host immune response (GO:0052553)6.49981247
5positive regulation by symbiont of host defense response (GO:0052509)6.49981247
6modulation by symbiont of host defense response (GO:0052031)6.49981247
7regulation of interferon-beta biosynthetic process (GO:0045357)4.85511950
8positive regulation of cellular amide metabolic process (GO:0034250)4.42141066
9macrophage activation involved in immune response (GO:0002281)4.41753033
10neutrophil activation involved in immune response (GO:0002283)4.26546622
11DNA deamination (GO:0045006)4.23173012
12response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.10277403
13response to host immune response (GO:0052572)4.10277403
14microglial cell activation (GO:0001774)3.98267426
15response to host (GO:0075136)3.83165752
16response to host defenses (GO:0052200)3.83165752
17response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83165752
18positive regulation of interferon-alpha production (GO:0032727)3.82422190
19proteasome assembly (GO:0043248)3.73172679
20response to peptidoglycan (GO:0032494)3.72101696
21hemidesmosome assembly (GO:0031581)3.68731182
22COPI coating of Golgi vesicle (GO:0048205)3.66768916
23Golgi transport vesicle coating (GO:0048200)3.66768916
24positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.63506435
25regulation of interferon-alpha production (GO:0032647)3.60905138
26regulation of cholesterol storage (GO:0010885)3.54424961
27platelet dense granule organization (GO:0060155)3.53523231
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53234791
29low-density lipoprotein particle clearance (GO:0034383)3.50958280
30positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.50038170
31amyloid precursor protein catabolic process (GO:0042987)3.37577851
32apoptotic cell clearance (GO:0043277)3.35179427
33negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.32204300
34mannosylation (GO:0097502)3.28874735
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23255484
36amino sugar catabolic process (GO:0046348)3.21659207
37negative regulation of response to reactive oxygen species (GO:1901032)3.14301206
38desmosome organization (GO:0002934)3.12197854
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12100847
40response to lipoprotein particle (GO:0055094)3.09810323
41regulation of membrane protein ectodomain proteolysis (GO:0051043)3.08425997
42keratan sulfate catabolic process (GO:0042340)3.03164651
43macrophage activation (GO:0042116)3.02099988
44eosinophil migration (GO:0072677)3.01697658
45sphingosine metabolic process (GO:0006670)3.01429706
46keratinocyte development (GO:0003334)2.98020048
47response to muramyl dipeptide (GO:0032495)2.93239896
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93071332
49dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.92346361
50lipopolysaccharide biosynthetic process (GO:0009103)2.92069686
51virion attachment to host cell (GO:0019062)2.91851942
52adhesion of symbiont to host cell (GO:0044650)2.91851942
53pinocytosis (GO:0006907)2.91656967
54pyrimidine ribonucleoside catabolic process (GO:0046133)2.91186897
55immunoglobulin mediated immune response (GO:0016064)2.89592321
56I-kappaB phosphorylation (GO:0007252)2.85189237
57negative regulation of protein autophosphorylation (GO:0031953)2.83548198
58skin morphogenesis (GO:0043589)2.82422365
59N-acetylneuraminate metabolic process (GO:0006054)2.81965727
60lytic vacuole organization (GO:0080171)2.81028191
61lysosome organization (GO:0007040)2.81028191
62regulation of hippo signaling (GO:0035330)2.80840361
63zinc ion transmembrane transport (GO:0071577)2.80669808
64UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80585205
65positive regulation of antigen processing and presentation (GO:0002579)2.77392691
66regulation of cellular amino acid metabolic process (GO:0006521)2.76800548
67regulation of hydrogen peroxide-induced cell death (GO:1903205)2.76390365
68regulation of sequestering of triglyceride (GO:0010889)2.75814925
69detection of molecule of bacterial origin (GO:0032490)2.75556882
70endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.75091516
71positive regulation of interferon-beta production (GO:0032728)2.75089213
72adhesion of symbiont to host (GO:0044406)2.73845637
73alanine transport (GO:0032328)2.73076332
74regulation of metalloenzyme activity (GO:0048552)2.71733055
75plasma lipoprotein particle clearance (GO:0034381)2.70372957
76positive regulation of monocyte chemotaxis (GO:0090026)2.68709071
77diol metabolic process (GO:0034311)2.66459172
78negative regulation of lipid storage (GO:0010888)2.66361190
79myeloid cell activation involved in immune response (GO:0002275)2.65979871
80mannose metabolic process (GO:0006013)2.62934558
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62767369
82phospholipid homeostasis (GO:0055091)2.62736378
83granulocyte activation (GO:0036230)2.62406641
84protein localization to endosome (GO:0036010)2.62228160
85GDP-mannose metabolic process (GO:0019673)2.61874058
86regulation of heat generation (GO:0031650)2.61548730
87sphingoid metabolic process (GO:0046519)2.61424588
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61422222
89neutrophil activation (GO:0042119)2.61401641
90lipoprotein transport (GO:0042953)2.61347229
91regulation of mononuclear cell migration (GO:0071675)2.61287898
92cell adhesion mediated by integrin (GO:0033627)2.59612568
93zinc ion transport (GO:0006829)2.58720870
94modification by symbiont of host morphology or physiology (GO:0044003)2.58666354
95serine transport (GO:0032329)2.57336620
96regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57175831
97respiratory burst (GO:0045730)2.55913681
98positive regulation of triglyceride biosynthetic process (GO:0010867)2.55739978
99positive regulation of chemokine biosynthetic process (GO:0045080)2.54804118
100amyloid precursor protein metabolic process (GO:0042982)2.53017359
101neutrophil mediated immunity (GO:0002446)2.52543910
102vagina development (GO:0060068)2.52249787
103endosome to melanosome transport (GO:0035646)2.52101494
104endosome to pigment granule transport (GO:0043485)2.52101494
105pH reduction (GO:0045851)2.50886439
106cellular zinc ion homeostasis (GO:0006882)2.50317550
107L-amino acid import (GO:0043092)2.50082298
108hydrogen peroxide biosynthetic process (GO:0050665)2.48281976
109phagosome maturation (GO:0090382)2.48245125
110lipopolysaccharide metabolic process (GO:0008653)2.48179583
111C-terminal protein lipidation (GO:0006501)2.47463151
112intracellular pH reduction (GO:0051452)2.46669267
113L-serine transport (GO:0015825)2.46112288
114wound healing, spreading of epidermal cells (GO:0035313)2.45781195
115regulation of apoptotic process involved in morphogenesis (GO:1902337)2.45197002
116oligosaccharide catabolic process (GO:0009313)2.44911812
117positive regulation of lipid storage (GO:0010884)2.43878521
118amino acid import (GO:0043090)2.43309808
119positive regulation of p38MAPK cascade (GO:1900745)2.43259723
120galactose metabolic process (GO:0006012)2.43224263
121positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.43068153
122positive regulation of smooth muscle cell migration (GO:0014911)2.42593859
123type B pancreatic cell proliferation (GO:0044342)2.42023599
124leukocyte migration involved in inflammatory response (GO:0002523)2.41391884
125regulation of cell proliferation involved in kidney development (GO:1901722)2.40695613
126L-phenylalanine metabolic process (GO:0006558)2.40528265
127erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.40528265
128positive regulation of heat generation (GO:0031652)2.40268150
129membrane raft organization (GO:0031579)2.40056854
130basic amino acid transport (GO:0015802)2.39682155
131negative regulation of interleukin-17 production (GO:0032700)2.38853654
132positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38748481
133regulation of mast cell degranulation (GO:0043304)2.37817272
134regulation of water loss via skin (GO:0033561)2.37033322
135negative regulation of macroautophagy (GO:0016242)2.36168146
136positive regulation of mast cell activation (GO:0033005)2.35857142
137regulation of antigen processing and presentation (GO:0002577)2.35772394
138C-terminal protein amino acid modification (GO:0018410)2.35474021
139regulation of fever generation (GO:0031620)2.34763802
140signal peptide processing (GO:0006465)2.34653803
141regulation of integrin-mediated signaling pathway (GO:2001044)2.34596547
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34172386
143positive regulation of macrophage cytokine production (GO:0060907)2.32214276
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.32153496
145energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.30893285
146ATP hydrolysis coupled proton transport (GO:0015991)2.30893285
147regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.30074669
148regulation of B cell receptor signaling pathway (GO:0050855)2.29849597
149glycosphingolipid metabolic process (GO:0006687)2.29146212
150autophagic vacuole fusion (GO:0000046)2.29030285
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.28948671
152galactose catabolic process (GO:0019388)2.28178697
153protein maturation by protein folding (GO:0022417)2.28167285
154negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.27618151
155fucose metabolic process (GO:0006004)2.27438244
156norepinephrine metabolic process (GO:0042415)2.26620583
157positive regulation of leukocyte degranulation (GO:0043302)2.26336695
158membrane lipid catabolic process (GO:0046466)2.26001176
159glycosphingolipid catabolic process (GO:0046479)2.25441806
160response to testosterone (GO:0033574)2.25437927
161positive regulation of interleukin-8 secretion (GO:2000484)2.25119000
162ER overload response (GO:0006983)2.24982034
163regulation of mast cell activation involved in immune response (GO:0033006)2.24528060
164nucleotide transmembrane transport (GO:1901679)2.24333334
165triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.23698333
166natural killer cell mediated immunity (GO:0002228)2.23405094
167natural killer cell mediated cytotoxicity (GO:0042267)2.23405094
168sphingolipid catabolic process (GO:0030149)2.23053453
169macroautophagy (GO:0016236)2.22955600
170L-methionine salvage (GO:0071267)2.22824410
171L-methionine biosynthetic process (GO:0071265)2.22824410
172amino acid salvage (GO:0043102)2.22824410
173dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22690604
174regulation of interleukin-8 biosynthetic process (GO:0045414)2.22170527
175positive regulation of toll-like receptor signaling pathway (GO:0034123)2.21888395
176zinc ion homeostasis (GO:0055069)2.20156136
177regulation of interleukin-8 secretion (GO:2000482)2.18814888
178glucosamine-containing compound catabolic process (GO:1901072)2.18487931
179positive regulation of B cell differentiation (GO:0045579)2.17713959
180phagocytosis, recognition (GO:0006910)2.16449253
181negative regulation of mast cell activation (GO:0033004)2.16353732
182eosinophil chemotaxis (GO:0048245)2.15467898
183cytidine deamination (GO:0009972)2.15201490
184cytidine metabolic process (GO:0046087)2.15201490
185cytidine catabolic process (GO:0006216)2.15201490
186wound healing, spreading of cells (GO:0044319)2.13870348
187positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.13377192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.83890316
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.27245043
3Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.83727372
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.71450571
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45671431
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.44925077
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.24716374
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.20743147
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94069504
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.88341746
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.84085535
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79333665
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.63857563
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55956312
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.42044500
16ZNF263_19887448_ChIP-Seq_K562_Human2.40777609
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40489844
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.34124543
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21866320
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20052205
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18130388
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.17045489
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12571182
24ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.06935998
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05418319
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.05410030
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.00563147
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.98292627
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96906190
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90258331
31SPI1_23127762_ChIP-Seq_K562_Human1.86311832
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83566815
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83560255
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82202279
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81116501
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.78081717
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77298384
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.77221694
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75014009
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74955158
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72707162
42VDR_24787735_ChIP-Seq_THP-1_Human1.72544551
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71358139
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70284616
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70284616
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68833973
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.66079497
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63507299
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.63380755
50TFEB_21752829_ChIP-Seq_HELA_Human1.61914643
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58646235
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58321714
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57579250
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56096937
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.54132724
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52480386
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52248157
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50681371
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49966987
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47995691
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43983079
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42849971
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42738885
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.38431362
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.38392835
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38088568
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37618823
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37478103
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.37432030
70ATF3_27146783_Chip-Seq_COLON_Human1.36612940
71GATA1_22025678_ChIP-Seq_K562_Human1.33119555
72DCP1A_22483619_ChIP-Seq_HELA_Human1.32309719
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28885899
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27972055
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27972055
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27093840
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26803414
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25811554
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25015273
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25010013
81GATA4_25053715_ChIP-Seq_YYC3_Human1.25009364
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24911277
83PU_27001747_Chip-Seq_BMDM_Mouse1.24637857
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22714023
85GATA3_24758297_ChIP-Seq_MCF-7_Human1.21009018
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20678045
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19525489
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.19394842
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18943367
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.17549243
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.17549243
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15248382
93CLOCK_20551151_ChIP-Seq_293T_Human1.15198088
94CJUN_26792858_Chip-Seq_BT549_Human1.14782832
95VDR_24763502_ChIP-Seq_THP-1_Human1.13606187
96GATA1_19941826_ChIP-Seq_K562_Human1.13338524
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13037629
98GATA2_19941826_ChIP-Seq_K562_Human1.12677292
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10734801
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10561682
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10297681
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09905226
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09666427
104RUNX_20019798_ChIP-Seq_JUKART_Human1.08782585
105GABP_19822575_ChIP-Seq_HepG2_Human1.08731084
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07656943
107BRD4_25478319_ChIP-Seq_HGPS_Human1.07529091
108PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07249471
109AHR_22903824_ChIP-Seq_MCF-7_Human1.06195295
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.04963944
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04924165
112ELF5_23300383_ChIP-Seq_T47D_Human1.03800909
113LXR_22292898_ChIP-Seq_THP-1_Human1.03237607
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02916023
115EST1_17652178_ChIP-ChIP_JURKAT_Human1.02278971
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01741435
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01397075
118SPI1_23547873_ChIP-Seq_NB4_Human1.01268890
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01126244
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00196788
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99951845
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99718434
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99527109
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99225584
125EOMES_21245162_ChIP-Seq_HESCs_Human0.98939002
126SOX2_20726797_ChIP-Seq_SW620_Human0.98491155
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98472013
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98273027
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.97318367
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97267871
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97262660
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97179974
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96397782
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.93804137
135SCL_19346495_ChIP-Seq_HPC-7_Human0.93444498
136CTCF_20526341_ChIP-Seq_ESCs_Human0.93403959
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.92941317
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92881397
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92795423
140TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92470411
141EGR1_19374776_ChIP-ChIP_THP-1_Human0.91669961
142GATA6_25053715_ChIP-Seq_YYC3_Human0.91555476
143MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91283770
144RXR_22108803_ChIP-Seq_LS180_Human0.91227875
145CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91158051
146E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90990395
147GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90758092
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.90430824
149STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90064652
150ELK1_19687146_ChIP-ChIP_HELA_Human0.90006406
151ZNF274_21170338_ChIP-Seq_K562_Hela0.89037179
152TP53_22127205_ChIP-Seq_IMR90_Human0.88678891
153FOXA2_19822575_ChIP-Seq_HepG2_Human0.88523403
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88089064
155SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87515153
156SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86808288
157RACK7_27058665_Chip-Seq_MCF-7_Human0.86498736
158CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85542345
159RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84605227
160CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82265547
161CDX2_20551321_ChIP-Seq_CACO-2_Human0.81943010
162RAC3_21632823_ChIP-Seq_H3396_Human0.81568259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.97992027
2MP0009840_abnormal_foam_cell4.33177958
3MP0003806_abnormal_nucleotide_metabolis3.29280999
4MP0003172_abnormal_lysosome_physiology3.13339924
5MP0006054_spinal_hemorrhage2.89311730
6MP0003191_abnormal_cellular_cholesterol2.65979481
7MP0003690_abnormal_glial_cell2.60392099
8MP0000569_abnormal_digit_pigmentation2.51893926
9MP0000604_amyloidosis2.45800556
10MP0004510_myositis2.33955555
11MP0002419_abnormal_innate_immunity2.31418828
12MP0003436_decreased_susceptibility_to2.30963932
13MP0003303_peritoneal_inflammation2.29289100
14MP0000015_abnormal_ear_pigmentation2.28373516
15MP0008438_abnormal_cutaneous_collagen2.25771601
16MP0008875_abnormal_xenobiotic_pharmacok2.22202795
17MP0010234_abnormal_vibrissa_follicle2.20804801
18MP0006082_CNS_inflammation2.18746509
19MP0000538_abnormal_urinary_bladder2.12802986
20MP0010386_abnormal_urinary_bladder2.08873122
21MP0001835_abnormal_antigen_presentation2.03653346
22MP0002254_reproductive_system_inflammat2.01598832
23MP0000343_altered_response_to1.99499393
24MP0003279_aneurysm1.96209934
25MP0003566_abnormal_cell_adhesion1.94284133
26MP0001661_extended_life_span1.92696348
27MP0004272_abnormal_basement_membrane1.84778255
28MP0003646_muscle_fatigue1.83834056
29MP0003950_abnormal_plasma_membrane1.81903056
30MP0005365_abnormal_bile_salt1.81241585
31MP0004130_abnormal_muscle_cell1.81205458
32MP0003011_delayed_dark_adaptation1.80571437
33MP0005408_hypopigmentation1.77333676
34MP0003075_altered_response_to1.68061058
35MP0005257_abnormal_intraocular_pressure1.67781138
36MP0001533_abnormal_skeleton_physiology1.66869562
37MP0003300_gastrointestinal_ulcer1.64971535
38MP0000371_diluted_coat_color1.62714523
39MP0002877_abnormal_melanocyte_morpholog1.61649784
40MP0002148_abnormal_hypersensitivity_rea1.60924067
41MP0001958_emphysema1.58185657
42MP0003705_abnormal_hypodermis_morpholog1.57089701
43MP0000427_abnormal_hair_cycle1.55374322
44MP0003656_abnormal_erythrocyte_physiolo1.53244849
45MP0004233_abnormal_muscle_weight1.51698170
46MP0002060_abnormal_skin_morphology1.51272885
47MP0009785_altered_susceptibility_to1.50516275
48MP0004019_abnormal_vitamin_homeostasis1.50454169
49MP0005000_abnormal_immune_tolerance1.48322493
50MP0005025_abnormal_response_to1.46468492
51MP0000516_abnormal_urinary_system1.45281733
52MP0005367_renal/urinary_system_phenotyp1.45281733
53MP0003195_calcinosis1.45168490
54MP0003091_abnormal_cell_migration1.43371670
55MP0000920_abnormal_myelination1.40948149
56MP0005167_abnormal_blood-brain_barrier1.39837507
57MP0005387_immune_system_phenotype1.39757268
58MP0001790_abnormal_immune_system1.39757268
59MP0002909_abnormal_adrenal_gland1.39499309
60MP0005464_abnormal_platelet_physiology1.39327383
61MP0001853_heart_inflammation1.37907586
62MP0000372_irregular_coat_pigmentation1.37278332
63MP0005083_abnormal_biliary_tract1.37056674
64MP0002452_abnormal_antigen_presenting1.35231303
65MP0002876_abnormal_thyroid_physiology1.33767813
66MP0001542_abnormal_bone_strength1.33604179
67MP0003724_increased_susceptibility_to1.32888043
68MP0003183_abnormal_peptide_metabolism1.32626756
69MP0002998_abnormal_bone_remodeling1.32036502
70MP0009764_decreased_sensitivity_to1.29460424
71MP0010678_abnormal_skin_adnexa1.28911268
72MP0003786_premature_aging1.27973436
73MP0003329_amyloid_beta_deposits1.27777682
74MP0000751_myopathy1.27682801
75MP0005171_absent_coat_pigmentation1.26755244
76MP0005023_abnormal_wound_healing1.26425972
77MP0004381_abnormal_hair_follicle1.25142800
78MP0004947_skin_inflammation1.23838609
79MP0009278_abnormal_bone_marrow1.23535034
80MP0008469_abnormal_protein_level1.22996452
81MP0003448_altered_tumor_morphology1.21686814
82MP0001216_abnormal_epidermal_layer1.21414086
83MP0001849_ear_inflammation1.18403852
84MP0000383_abnormal_hair_follicle1.17187189
85MP0008260_abnormal_autophagy1.16937931
86MP0004084_abnormal_cardiac_muscle1.15249946
87MP0000749_muscle_degeneration1.14827322
88MP0002723_abnormal_immune_serum1.14134001
89MP0005360_urolithiasis1.12731819
90MP0000685_abnormal_immune_system1.11962564
91MP0002837_dystrophic_cardiac_calcinosis1.11871222
92MP0004858_abnormal_nervous_system1.11731908
93MP0000750_abnormal_muscle_regeneration1.11294061
94MP0003634_abnormal_glial_cell1.10667778
95MP0002139_abnormal_hepatobiliary_system1.09115708
96MP0000647_abnormal_sebaceous_gland1.08689611
97MP0005332_abnormal_amino_acid1.08429232
98MP0005075_abnormal_melanosome_morpholog1.08082214
99MP0001243_abnormal_dermal_layer1.07088484
100MP0005085_abnormal_gallbladder_physiolo1.06718646
101MP0003828_pulmonary_edema1.06346462
102MP0001800_abnormal_humoral_immune1.00702289
103MP0005166_decreased_susceptibility_to0.99073922
104MP0005165_increased_susceptibility_to0.98822887
105MP0008775_abnormal_heart_ventricle0.98626579
106MP0002972_abnormal_cardiac_muscle0.98330691
107MP0003186_abnormal_redox_activity0.98169487
108MP0002098_abnormal_vibrissa_morphology0.98010766
109MP0005330_cardiomyopathy0.96892104
110MP0010329_abnormal_lipoprotein_level0.96202523
111MP0004185_abnormal_adipocyte_glucose0.96111479
112MP0009643_abnormal_urine_homeostasis0.95974646
113MP0001845_abnormal_inflammatory_respons0.95969909
114MP0000858_altered_metastatic_potential0.95901288
115MP0000358_abnormal_cell_content/0.95599083
116MP0000467_abnormal_esophagus_morphology0.94989388
117MP0002075_abnormal_coat/hair_pigmentati0.94578140
118MP0002090_abnormal_vision0.94527803
119MP0005666_abnormal_adipose_tissue0.94317834
120MP0000767_abnormal_smooth_muscle0.93651331
121MP0001756_abnormal_urination0.93173034
122MP0002896_abnormal_bone_mineralization0.93090327
123MP0009780_abnormal_chondrocyte_physiolo0.92691151
124MP0003045_fibrosis0.92543823
125MP0004087_abnormal_muscle_fiber0.92365926
126MP0010771_integument_phenotype0.92239997
127MP0002332_abnormal_exercise_endurance0.92149157
128MP0001819_abnormal_immune_cell0.91823616
129MP0005174_abnormal_tail_pigmentation0.91775654
130MP0003136_yellow_coat_color0.91308045
131MP0002118_abnormal_lipid_homeostasis0.90936610
132MP0000609_abnormal_liver_physiology0.90880981
133MP0002971_abnormal_brown_adipose0.90733921
134MP0000377_abnormal_hair_follicle0.90603779
135MP0002420_abnormal_adaptive_immunity0.89381710
136MP0005197_abnormal_uvea_morphology0.88293291
137MP0009763_increased_sensitivity_to0.87729181
138MP0001324_abnormal_eye_pigmentation0.87540670
139MP0000579_abnormal_nail_morphology0.87266277
140MP0005319_abnormal_enzyme/_coenzyme0.87239435
141MP0005670_abnormal_white_adipose0.86787827
142MP0004215_abnormal_myocardial_fiber0.84389659
143MP0005595_abnormal_vascular_smooth0.83969958
144MP0005310_abnormal_salivary_gland0.83864884
145MP0005390_skeleton_phenotype0.83125035
146MP0001186_pigmentation_phenotype0.82556576
147MP0001544_abnormal_cardiovascular_syste0.82498121
148MP0005385_cardiovascular_system_phenoty0.82498121
149MP0000367_abnormal_coat/_hair0.82428761
150MP0002168_other_aberrant_phenotype0.82206223
151MP0005164_abnormal_response_to0.80517912
152MP0000249_abnormal_blood_vessel0.80207215
153MP0002295_abnormal_pulmonary_circulatio0.80200079
154MP0005451_abnormal_body_composition0.79730509
155MP0002102_abnormal_ear_morphology0.78792034
156MP0005275_abnormal_skin_tensile0.78623865
157MP0003453_abnormal_keratinocyte_physiol0.77779259
158MP0003252_abnormal_bile_duct0.77050401
159MP0005584_abnormal_enzyme/coenzyme_acti0.75772752
160MP0005501_abnormal_skin_physiology0.74160153
161MP0000627_abnormal_mammary_gland0.71917642
162MP0005508_abnormal_skeleton_morphology0.71881298
163MP0001873_stomach_inflammation0.71423582
164MP0005671_abnormal_response_to0.70837067

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.81711921
2Increased neuronal autofluorescent lipopigment (HP:0002074)4.97459937
3Recurrent abscess formation (HP:0002722)4.78428608
4Axonal loss (HP:0003447)4.72196046
5Vacuolated lymphocytes (HP:0001922)4.62687802
6Abnormality of macrophages (HP:0004311)4.35877265
7Recurrent bacterial skin infections (HP:0005406)4.32279639
8Dysostosis multiplex (HP:0000943)4.06781886
9Abnormality of glycolipid metabolism (HP:0010969)4.04692344
10Abnormality of liposaccharide metabolism (HP:0010968)4.04692344
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.04692344
12Systemic lupus erythematosus (HP:0002725)3.95736628
13Eczematoid dermatitis (HP:0000976)3.76535998
14Recurrent gram-negative bacterial infections (HP:0005420)3.59478395
15Loss of speech (HP:0002371)3.56984159
16Myocardial infarction (HP:0001658)3.55237363
17Neurofibrillary tangles (HP:0002185)3.42624616
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.42044299
19Mucopolysacchariduria (HP:0008155)3.33660686
20Urinary glycosaminoglycan excretion (HP:0003541)3.33660686
21Abnormality of polysaccharide metabolism (HP:0011012)3.31414086
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.31414086
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.31414086
24Hypokinesia (HP:0002375)3.25154492
25Asymmetric septal hypertrophy (HP:0001670)3.13907880
26Cervical subluxation (HP:0003308)3.06229186
27Tetraparesis (HP:0002273)3.01454489
28Tongue fasciculations (HP:0001308)2.98741777
29Xanthomatosis (HP:0000991)2.89343010
30Abnormal protein glycosylation (HP:0012346)2.85054272
31Abnormal glycosylation (HP:0012345)2.85054272
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.85054272
33Abnormal protein N-linked glycosylation (HP:0012347)2.85054272
34Type I transferrin isoform profile (HP:0003642)2.82360603
35Vascular calcification (HP:0004934)2.81578886
36Gingivitis (HP:0000230)2.71975447
37Thick nail (HP:0001805)2.68676898
38Cutaneous melanoma (HP:0012056)2.68546874
39Cardiovascular calcification (HP:0011915)2.62006563
40Hypoalphalipoproteinemia (HP:0003233)2.58344337
41Glomerulonephritis (HP:0000099)2.57376965
42Autoimmune thrombocytopenia (HP:0001973)2.52720972
43Premature rupture of membranes (HP:0001788)2.50534951
44Cerebral inclusion bodies (HP:0100314)2.50136727
45Large for gestational age (HP:0001520)2.49728626
46Muscle fibrillation (HP:0010546)2.49416891
47Disinhibition (HP:0000734)2.48594098
48Recurrent skin infections (HP:0001581)2.46989933
49Osteolytic defects of the hand bones (HP:0009699)2.44566721
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.44566721
51Peripheral demyelination (HP:0011096)2.42448240
52Hyperlipoproteinemia (HP:0010980)2.39675361
53Supranuclear gaze palsy (HP:0000605)2.36534241
54Amyloidosis (HP:0011034)2.35033792
55Poor head control (HP:0002421)2.29391517
56Basal ganglia calcification (HP:0002135)2.29134394
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27385510
58Urticaria (HP:0001025)2.26514008
59Turricephaly (HP:0000262)2.25424857
60Prolonged neonatal jaundice (HP:0006579)2.25390006
61Nuclear cataract (HP:0100018)2.22332538
62Pathologic fracture (HP:0002756)2.21033946
63Hepatosplenomegaly (HP:0001433)2.19799613
64Hypoplasia of the odontoid process (HP:0003311)2.19518764
65Short nail (HP:0001799)2.19002618
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18618485
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18618485
68Neuronal loss in central nervous system (HP:0002529)2.14903914
69Entropion (HP:0000621)2.12768003
70Plantar hyperkeratosis (HP:0007556)2.11788553
71Stomatitis (HP:0010280)2.11273924
72Complement deficiency (HP:0004431)2.10474219
73Alopecia of scalp (HP:0002293)2.09338135
74Opisthotonus (HP:0002179)2.08453790
75J-shaped sella turcica (HP:0002680)2.07425581
76Cerebral aneurysm (HP:0004944)2.06668462
77Fragile nails (HP:0001808)2.05735284
78Global brain atrophy (HP:0002283)2.05021183
79Abnormality of the distal phalanges of the toes (HP:0010182)2.04832522
80Cardiomegaly (HP:0001640)2.04534868
81Hamartoma of the eye (HP:0010568)2.04038118
82Muscle fiber splitting (HP:0003555)2.03853454
83Onycholysis (HP:0001806)2.03091001
84Sparse eyelashes (HP:0000653)2.01993794
85Beaking of vertebral bodies (HP:0004568)2.01607250
86Vertebral compression fractures (HP:0002953)2.00816343
87Nephritis (HP:0000123)1.99951341
88Hypercholesterolemia (HP:0003124)1.99609826
89Hydroxyprolinuria (HP:0003080)1.98848313
90Abnormality of proline metabolism (HP:0010907)1.98848313
91Ventricular tachycardia (HP:0004756)1.98433892
92Retinal atrophy (HP:0001105)1.98161452
93Orchitis (HP:0100796)1.97644403
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97306607
95Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97245520
96Abnormality of complement system (HP:0005339)1.93738207
97Albinism (HP:0001022)1.93549126
98Bone pain (HP:0002653)1.93077177
99Aplasia involving bones of the extremities (HP:0009825)1.92890178
100Aplasia involving bones of the upper limbs (HP:0009823)1.92890178
101Aplasia of the phalanges of the hand (HP:0009802)1.92890178
102Mediastinal lymphadenopathy (HP:0100721)1.92820577
103Premature loss of primary teeth (HP:0006323)1.90801602
104Increased serum ferritin (HP:0003281)1.89755735
105Distal lower limb muscle weakness (HP:0009053)1.89407217
106Upper motor neuron abnormality (HP:0002127)1.89271428
107Increased connective tissue (HP:0009025)1.88093761
108Atrophic scars (HP:0001075)1.87091075
109Bone cyst (HP:0012062)1.86775725
110Nausea (HP:0002018)1.86520813
111Skin nodule (HP:0200036)1.86502488
112Spastic paraparesis (HP:0002313)1.86384201
113Abnormality of fatty-acid metabolism (HP:0004359)1.86346279
114Hyporeflexia of lower limbs (HP:0002600)1.85388491
115Sudden death (HP:0001699)1.85209988
116Progressive visual loss (HP:0000529)1.84595142
117Amelogenesis imperfecta (HP:0000705)1.82932058
118Congenital ichthyosiform erythroderma (HP:0007431)1.82431720
119Right ventricular cardiomyopathy (HP:0011663)1.82281236
120Paraparesis (HP:0002385)1.81535734
121Exercise-induced muscle cramps (HP:0003710)1.81136629
122Palmoplantar hyperkeratosis (HP:0000972)1.79526493
123Ovoid vertebral bodies (HP:0003300)1.78916449
124Abnormality of the odontoid process (HP:0003310)1.78641705
125Mesangial abnormality (HP:0001966)1.78322388
126Bilateral sensorineural hearing impairment (HP:0008619)1.78041729
127Protuberant abdomen (HP:0001538)1.77908008
128Myositis (HP:0100614)1.77411297
129Periodontitis (HP:0000704)1.77031222
130Progressive neurologic deterioration (HP:0002344)1.75499521
131Delayed gross motor development (HP:0002194)1.75074502
132Natal tooth (HP:0000695)1.73170950
133Aplasia/hypoplasia of the uterus (HP:0008684)1.71906374
134Disproportionate short-trunk short stature (HP:0003521)1.71692115
135Concave nail (HP:0001598)1.69930768
136Personality changes (HP:0000751)1.68944649
137Neoplasm of head and neck (HP:0012288)1.68729517
138Esophageal neoplasm (HP:0100751)1.68729517
139Clumsiness (HP:0002312)1.67520904
140Pustule (HP:0200039)1.67025155
141Ketoacidosis (HP:0001993)1.66876314
142Distal lower limb amyotrophy (HP:0008944)1.66545405
143Nail dystrophy (HP:0008404)1.66399131
144Abnormality of iron homeostasis (HP:0011031)1.66163462
145Methylmalonic aciduria (HP:0012120)1.66124606
146Sensorimotor neuropathy (HP:0007141)1.66032080
147Apathy (HP:0000741)1.66025434
148Deformed sella turcica (HP:0002681)1.65997884
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65426090
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.64571828
151Abnormality of the lumbar spine (HP:0100712)1.64280357
152Increased corneal curvature (HP:0100692)1.64070551
153Keratoconus (HP:0000563)1.64070551
154Congenital, generalized hypertrichosis (HP:0004540)1.63749233
155Mitral stenosis (HP:0001718)1.63301082
156Broad face (HP:0000283)1.60484612
157Microretrognathia (HP:0000308)1.59600146
158Generalized amyotrophy (HP:0003700)1.58925306
159Rough bone trabeculation (HP:0100670)1.58779614
160Upper limb amyotrophy (HP:0009129)1.57904581
161Distal upper limb amyotrophy (HP:0007149)1.57904581
162Hematochezia (HP:0002573)1.57260754
163Follicular hyperkeratosis (HP:0007502)1.56973291
164Aortic valve stenosis (HP:0001650)1.56867953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.55909003
2TTN3.43132379
3MAPKAPK33.36471402
4IRAK33.35218597
5TRIB33.28258855
6FRK2.93163246
7ERN12.81813577
8BLK2.65133479
9EPHB12.59381805
10TBK12.57414146
11RIPK42.56139659
12LIMK12.44800094
13KIT2.40674440
14MAP3K122.37012053
15RIPK12.36821088
16TYK22.32150190
17ADRBK22.24380502
18MAP2K32.19649958
19PAK42.11490167
20PBK2.10666337
21MAP3K142.01798973
22TXK1.99858869
23MAP3K131.89955011
24IRAK41.88069296
25TESK21.84098220
26LMTK21.81511926
27FER1.74561546
28JAK11.71706976
29TGFBR21.67343471
30PHKG11.66330665
31PHKG21.66330665
32MUSK1.65450879
33CAMK1D1.53723292
34CAMK1G1.50897175
35TLK11.45359708
36STK101.44305699
37EPHB21.42726810
38TRPM71.41906755
39FGR1.38125397
40EIF2AK31.37671567
41DMPK1.35559269
42MAPK121.32547943
43TAOK31.29597264
44ACVR1B1.28089506
45PRKCI1.27737955
46IKBKE1.21099495
47IKBKB1.18742481
48PTK61.18652871
49MET1.14669543
50CSF1R1.12337690
51GRK11.11054105
52MST41.07014957
53HCK1.06639902
54CSK1.05490011
55WNK41.02864581
56JAK31.01993474
57BMX0.99735713
58PRKD20.99708511
59SIK10.97812703
60ADRBK10.96537379
61ABL20.93497862
62KDR0.91036642
63MST1R0.90348749
64JAK20.88829544
65CSNK1A1L0.88694330
66MAP3K50.88493902
67PDPK10.87083814
68SIK30.86211053
69PKN20.85292026
70MAP4K10.85172510
71GRK70.83656698
72BMPR1B0.82636545
73PDK20.78764303
74CSNK1G30.78298490
75MAPKAPK50.77933922
76ZAP700.77617498
77FES0.76505547
78LRRK20.75714116
79EIF2AK10.73127407
80PRKD10.72797521
81CHUK0.72253868
82NTRK10.71715607
83BUB10.68734372
84MAP2K60.64902170
85NUAK10.64475603
86GSK3A0.64023532
87ERBB40.63340602
88PRKCD0.63077567
89DAPK30.62977883
90MAP3K30.62686428
91FLT30.62488736
92STK390.62244404
93CAMKK20.60562026
94MOS0.60550964
95PKN10.59037818
96CAMK2G0.58288423
97STK40.58257049
98ARAF0.58091073
99ZAK0.57303679
100PRKCH0.57268766
101PAK60.57153058
102MAP4K20.57124541
103EIF2AK20.56546853
104MAP2K10.56431173
105PDGFRA0.56350493
106PDK10.55945946
107EGFR0.54554800
108TIE10.54375784
109MAPKAPK20.54335505
110KSR20.54150085
111ROCK10.54083775
112CSNK1G10.53627437
113BCKDK0.53003056
114ABL10.52968469
115PIM20.52106092
116VRK20.51512471
117TGFBR10.51062992
118NEK90.50934049
119LYN0.50379649
120STK380.50015842
121PRKAA20.49311373
122PIK3CA0.48733840
123PRKCE0.47886578
124CSNK1G20.46956066
125LCK0.46197427
126SYK0.45968205
127PTK20.45189738
128PAK20.44779854
129MELK0.43307362
130PDGFRB0.43116709
131MYLK0.42788656
132FYN0.42485723
133BRSK10.41607900
134PRKG20.41593999
135SGK30.41141928
136PAK30.40685003
137MAPK70.40155472
138IRAK10.40113341
139FGFR40.39661935
140ICK0.39507734
141PRKCQ0.39351127
142ILK0.39312027
143MAP3K20.38616494
144DAPK10.38302960
145NME20.38197107
146OBSCN0.37021294
147IGF1R0.36875748
148WNK10.36454761
149CAMK2D0.35809222
150INSRR0.35658421
151RPS6KA20.35321874
152MATK0.35228452
153DDR20.35171794
154MAP3K10.34570490
155CAMK2B0.34085408
156SRC0.33684526
157TESK10.31623802

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041423.42032510
2Proteasome_Homo sapiens_hsa030503.38831783
3Staphylococcus aureus infection_Homo sapiens_hsa051503.00904179
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.79639440
5Sulfur metabolism_Homo sapiens_hsa009202.64749494
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.60035660
7Other glycan degradation_Homo sapiens_hsa005112.23970029
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20433642
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14728806
10Steroid biosynthesis_Homo sapiens_hsa001002.07775986
11Leishmaniasis_Homo sapiens_hsa051402.04841963
12N-Glycan biosynthesis_Homo sapiens_hsa005101.96962435
13Malaria_Homo sapiens_hsa051441.94482600
14Vitamin B6 metabolism_Homo sapiens_hsa007501.92865252
15Phagosome_Homo sapiens_hsa041451.89835646
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85557017
17Osteoclast differentiation_Homo sapiens_hsa043801.80951334
18Tuberculosis_Homo sapiens_hsa051521.77786335
19Rheumatoid arthritis_Homo sapiens_hsa053231.77187793
20Galactose metabolism_Homo sapiens_hsa000521.75653222
21Fatty acid degradation_Homo sapiens_hsa000711.72939975
22Fatty acid metabolism_Homo sapiens_hsa012121.69820051
23Protein export_Homo sapiens_hsa030601.69305032
24Oxidative phosphorylation_Homo sapiens_hsa001901.61882415
25Selenocompound metabolism_Homo sapiens_hsa004501.56807012
26Pertussis_Homo sapiens_hsa051331.53921905
27Caffeine metabolism_Homo sapiens_hsa002321.49969270
28Complement and coagulation cascades_Homo sapiens_hsa046101.41643838
29Collecting duct acid secretion_Homo sapiens_hsa049661.41587645
30PPAR signaling pathway_Homo sapiens_hsa033201.37131399
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36086442
32Fatty acid biosynthesis_Homo sapiens_hsa000611.35905460
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31188267
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28648831
35Glutathione metabolism_Homo sapiens_hsa004801.26508150
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21843297
37Butanoate metabolism_Homo sapiens_hsa006501.19676529
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.18411205
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17186537
40Nitrogen metabolism_Homo sapiens_hsa009101.14817410
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13312455
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.13206070
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.12528662
44Legionellosis_Homo sapiens_hsa051341.12254539
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12140457
46Salmonella infection_Homo sapiens_hsa051321.12039746
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11467700
48Toxoplasmosis_Homo sapiens_hsa051451.10726323
49Tryptophan metabolism_Homo sapiens_hsa003801.06658688
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04346933
51Fatty acid elongation_Homo sapiens_hsa000621.02899019
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01828580
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99723673
54B cell receptor signaling pathway_Homo sapiens_hsa046620.98829936
55Sphingolipid metabolism_Homo sapiens_hsa006000.98547579
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96659076
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96507589
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.96431484
59Apoptosis_Homo sapiens_hsa042100.93993651
60RNA polymerase_Homo sapiens_hsa030200.92598792
61Peroxisome_Homo sapiens_hsa041460.92532228
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91743002
63Viral myocarditis_Homo sapiens_hsa054160.91297745
64TNF signaling pathway_Homo sapiens_hsa046680.90851139
65Shigellosis_Homo sapiens_hsa051310.90811593
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90593065
67Mineral absorption_Homo sapiens_hsa049780.90193675
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89307723
69Chemical carcinogenesis_Homo sapiens_hsa052040.89209360
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88434017
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88322072
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87460534
73Dilated cardiomyopathy_Homo sapiens_hsa054140.83379850
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83333198
75Amoebiasis_Homo sapiens_hsa051460.82852810
76Influenza A_Homo sapiens_hsa051640.82297997
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80198445
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80038900
79Sulfur relay system_Homo sapiens_hsa041220.79530881
80beta-Alanine metabolism_Homo sapiens_hsa004100.79463763
81Metabolic pathways_Homo sapiens_hsa011000.78333678
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78112126
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.77749045
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77534780
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77380939
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77340643
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76765436
88Arginine biosynthesis_Homo sapiens_hsa002200.75527059
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75098338
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73447299
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.72608549
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72145189
93Alzheimers disease_Homo sapiens_hsa050100.71377025
94Propanoate metabolism_Homo sapiens_hsa006400.71281410
95Measles_Homo sapiens_hsa051620.70601137
96Hepatitis C_Homo sapiens_hsa051600.70381993
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.68029102
98Histidine metabolism_Homo sapiens_hsa003400.66247241
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65668560
100Starch and sucrose metabolism_Homo sapiens_hsa005000.65397424
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63259821
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63145033
103Parkinsons disease_Homo sapiens_hsa050120.62911319
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62524117
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62448119
106Antigen processing and presentation_Homo sapiens_hsa046120.62377907
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.61363737
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.60737078
109Insulin resistance_Homo sapiens_hsa049310.60089681
110Regulation of autophagy_Homo sapiens_hsa041400.58666161
111Endocytosis_Homo sapiens_hsa041440.58419180
112African trypanosomiasis_Homo sapiens_hsa051430.57761113
113Carbon metabolism_Homo sapiens_hsa012000.56451057
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56067701
115Ovarian steroidogenesis_Homo sapiens_hsa049130.55438720
116Chemokine signaling pathway_Homo sapiens_hsa040620.54419386
117Pyrimidine metabolism_Homo sapiens_hsa002400.52131758
118Proteoglycans in cancer_Homo sapiens_hsa052050.51462217
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51206832
120Arachidonic acid metabolism_Homo sapiens_hsa005900.51030379
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50615490
122ABC transporters_Homo sapiens_hsa020100.48838304
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48826020
124Retinol metabolism_Homo sapiens_hsa008300.48670694
125Prion diseases_Homo sapiens_hsa050200.48093084
126Vibrio cholerae infection_Homo sapiens_hsa051100.47915599
127Glycerolipid metabolism_Homo sapiens_hsa005610.47093498
128Vitamin digestion and absorption_Homo sapiens_hsa049770.46926539
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45671025
130Tyrosine metabolism_Homo sapiens_hsa003500.45354798
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45306332
132Allograft rejection_Homo sapiens_hsa053300.44956102
133Folate biosynthesis_Homo sapiens_hsa007900.44671076
134Pancreatic cancer_Homo sapiens_hsa052120.44398065
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.43124681
136Fructose and mannose metabolism_Homo sapiens_hsa000510.42991698
137Renal cell carcinoma_Homo sapiens_hsa052110.42545144
138Bile secretion_Homo sapiens_hsa049760.42248029
139Arginine and proline metabolism_Homo sapiens_hsa003300.41397507
140Focal adhesion_Homo sapiens_hsa045100.41011108
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40418644
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39361947
143ECM-receptor interaction_Homo sapiens_hsa045120.39338972
144Ether lipid metabolism_Homo sapiens_hsa005650.38905225
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.38758090
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38196593
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38000569
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37326269
149Linoleic acid metabolism_Homo sapiens_hsa005910.35701415
150Bladder cancer_Homo sapiens_hsa052190.34180202
151p53 signaling pathway_Homo sapiens_hsa041150.28693583
152Huntingtons disease_Homo sapiens_hsa050160.23975298
153TGF-beta signaling pathway_Homo sapiens_hsa043500.22242417

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