SLC35E3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.95429264
2regulation of sequestering of triglyceride (GO:0010889)6.79958201
3behavioral response to nicotine (GO:0035095)6.44592535
4valine metabolic process (GO:0006573)6.23479517
5low-density lipoprotein particle clearance (GO:0034383)6.16214688
6regulation of cholesterol storage (GO:0010885)5.19150669
7cellular response to vitamin (GO:0071295)5.17579709
8fucose catabolic process (GO:0019317)5.12972909
9L-fucose metabolic process (GO:0042354)5.12972909
10L-fucose catabolic process (GO:0042355)5.12972909
11white fat cell differentiation (GO:0050872)5.09985434
12brown fat cell differentiation (GO:0050873)5.06302026
13triglyceride catabolic process (GO:0019433)4.91550991
14acylglycerol catabolic process (GO:0046464)4.62144677
15neutral lipid catabolic process (GO:0046461)4.62144677
16kynurenine metabolic process (GO:0070189)4.57319486
17indole-containing compound catabolic process (GO:0042436)4.56309690
18indolalkylamine catabolic process (GO:0046218)4.56309690
19tryptophan catabolic process (GO:0006569)4.56309690
20positive regulation of protein export from nucleus (GO:0046827)4.55711418
21branched-chain amino acid catabolic process (GO:0009083)4.46953699
22negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.34200053
23response to UV-C (GO:0010225)4.32751353
24negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)4.31978487
25alpha-linolenic acid metabolic process (GO:0036109)4.26282224
26branched-chain amino acid metabolic process (GO:0009081)4.23680878
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.23093187
28indolalkylamine metabolic process (GO:0006586)4.06251149
29negative regulation of translation, ncRNA-mediated (GO:0040033)4.03246751
30regulation of translation, ncRNA-mediated (GO:0045974)4.03246751
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.03246751
32regulation of gene silencing by RNA (GO:0060966)3.99504441
33regulation of posttranscriptional gene silencing (GO:0060147)3.99504441
34regulation of gene silencing by miRNA (GO:0060964)3.99504441
35regulation of hippo signaling (GO:0035330)3.99453807
364-hydroxyproline metabolic process (GO:0019471)3.88019735
37NADH metabolic process (GO:0006734)3.84674682
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.83610747
39epoxygenase P450 pathway (GO:0019373)3.80758412
40positive regulation of glomerulus development (GO:0090193)3.80283477
41regulation of glycogen (starch) synthase activity (GO:2000465)3.79671751
42tryptophan metabolic process (GO:0006568)3.79501457
43response to magnesium ion (GO:0032026)3.76604975
44embryonic retina morphogenesis in camera-type eye (GO:0060059)3.76391918
45regulation of protein export from nucleus (GO:0046825)3.72324433
46positive regulation of fatty acid oxidation (GO:0046321)3.66205999
47glycerolipid catabolic process (GO:0046503)3.65333690
48cellular response to ATP (GO:0071318)3.61388760
49response to pheromone (GO:0019236)3.58516997
50triglyceride biosynthetic process (GO:0019432)3.56805985
51cellular ketone body metabolic process (GO:0046950)3.52146878
52peptidyl-proline hydroxylation (GO:0019511)3.48217003
53detection of light stimulus involved in sensory perception (GO:0050962)3.47831285
54detection of light stimulus involved in visual perception (GO:0050908)3.47831285
55negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.45979982
56regulation of macrophage derived foam cell differentiation (GO:0010743)3.38758205
57protein import into peroxisome matrix (GO:0016558)3.38584919
58indole-containing compound metabolic process (GO:0042430)3.38389938
59primary amino compound metabolic process (GO:1901160)3.37487668
60sulfur amino acid catabolic process (GO:0000098)3.37200498
61negative regulation of cell cycle arrest (GO:0071157)3.36814364
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36455225
63acylglycerol biosynthetic process (GO:0046463)3.35291921
64neutral lipid biosynthetic process (GO:0046460)3.35291921
65lipid particle organization (GO:0034389)3.33932799
66sulfation (GO:0051923)3.30703394
67neuronal action potential (GO:0019228)3.30386954
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28467710
69chondrocyte proliferation (GO:0035988)3.24181986
70serotonin metabolic process (GO:0042428)3.19822549
71protein destabilization (GO:0031648)3.19458099
72cilium or flagellum-dependent cell motility (GO:0001539)3.14428458
73collagen fibril organization (GO:0030199)3.14075636
74ketone body metabolic process (GO:1902224)3.12387243
75oxidative demethylation (GO:0070989)3.10567342
76cellular response to antibiotic (GO:0071236)3.10511807
77gamma-aminobutyric acid transport (GO:0015812)3.09316849
78endosome to pigment granule transport (GO:0043485)3.08697477
79endosome to melanosome transport (GO:0035646)3.08697477
80negative regulation of telomere maintenance (GO:0032205)3.08551069
81basement membrane organization (GO:0071711)3.07756416
82neural tube formation (GO:0001841)3.06266790
83cellular response to nutrient (GO:0031670)3.05739119
84regulation of glucose import in response to insulin stimulus (GO:2001273)3.05576314
85positive regulation of fatty acid metabolic process (GO:0045923)3.04291822
86positive regulation of lipid storage (GO:0010884)3.04043109
87complement activation, alternative pathway (GO:0006957)3.04038673
88plasma lipoprotein particle clearance (GO:0034381)3.03814627
89positive regulation of CREB transcription factor activity (GO:0032793)3.03319532
90amine catabolic process (GO:0009310)3.02715556
91cellular biogenic amine catabolic process (GO:0042402)3.02715556
92negative regulation of protein autophosphorylation (GO:0031953)3.02351198
93interkinetic nuclear migration (GO:0022027)3.02148786
94response to lipoprotein particle (GO:0055094)3.02118909
95cellular response to lithium ion (GO:0071285)3.00054975
96nephron epithelium morphogenesis (GO:0072088)2.98206378
97nephron tubule morphogenesis (GO:0072078)2.98206378
98fatty acid oxidation (GO:0019395)2.97629385
99snRNA transcription (GO:0009301)2.97084432
100negative regulation of DNA biosynthetic process (GO:2000279)2.97076399
101cornea development in camera-type eye (GO:0061303)2.96655253
102peristalsis (GO:0030432)2.95322959
103NAD biosynthetic process (GO:0009435)2.94196850
104positive regulation of glycolytic process (GO:0045821)2.93187018
105lipid oxidation (GO:0034440)2.90985849
106nonmotile primary cilium assembly (GO:0035058)2.90779526
107regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.90481996
108outer ear morphogenesis (GO:0042473)2.90370484
109regulation of nuclear cell cycle DNA replication (GO:0033262)2.90157518
110regulation of action potential (GO:0098900)2.89865414
111DNA deamination (GO:0045006)2.89642094
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88997474
113fatty acid beta-oxidation (GO:0006635)2.88280878
114tricarboxylic acid metabolic process (GO:0072350)2.87216255
115spinal cord motor neuron differentiation (GO:0021522)2.86226274
116fucosylation (GO:0036065)2.86223468
117retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85698949
118cellular response to exogenous dsRNA (GO:0071360)2.85245114
119triglyceride homeostasis (GO:0070328)2.84112856
120acylglycerol homeostasis (GO:0055090)2.84112856
121reflex (GO:0060004)2.83735221
122pyrimidine nucleobase catabolic process (GO:0006208)2.83708365
123triglyceride metabolic process (GO:0006641)2.81579962
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80574066
125cAMP catabolic process (GO:0006198)2.80503985
126negative regulation of smooth muscle cell migration (GO:0014912)2.79675694
127behavioral response to ethanol (GO:0048149)2.79554919
128negative regulation of systemic arterial blood pressure (GO:0003085)2.78679786
129regulation of fatty acid beta-oxidation (GO:0031998)2.78297481
130regulation of mesoderm development (GO:2000380)2.78131500
131response to morphine (GO:0043278)2.78103254
132reciprocal meiotic recombination (GO:0007131)2.77639189
133reciprocal DNA recombination (GO:0035825)2.77639189
134protein hydroxylation (GO:0018126)2.77562685
135nucleobase catabolic process (GO:0046113)2.75003478
136negative regulation of mast cell activation (GO:0033004)2.73963467
137fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73756028
138collagen catabolic process (GO:0030574)2.73358580
139skin morphogenesis (GO:0043589)2.73266409
140positive regulation of fatty acid beta-oxidation (GO:0032000)2.73071114
141negative regulation of reactive oxygen species metabolic process (GO:2000378)2.72836427
142positive regulation of glucose import (GO:0046326)2.72352889
143biotin metabolic process (GO:0006768)2.70604313
144regulation of fatty acid oxidation (GO:0046320)2.69883243
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.69508366
146kidney morphogenesis (GO:0060993)2.69347579
147response to iron ion (GO:0010039)2.68638418
148negative regulation of sodium ion transport (GO:0010766)2.68003558
149negative regulation of lipid storage (GO:0010888)2.66330603
150iron ion import (GO:0097286)2.66151551
151acylglycerol metabolic process (GO:0006639)2.65045100
152cardiovascular system development (GO:0072358)2.64637637
153positive regulation of developmental pigmentation (GO:0048087)2.64573013
154positive regulation of extracellular matrix organization (GO:1903055)2.64019751
155positive regulation of glucose transport (GO:0010828)2.63079422
156collagen metabolic process (GO:0032963)2.62742053
157histone-serine phosphorylation (GO:0035404)2.62648671
1582-oxoglutarate metabolic process (GO:0006103)2.62342827
159neutral lipid metabolic process (GO:0006638)2.62238404
160fatty acid catabolic process (GO:0009062)2.60497201
161carnitine metabolic process (GO:0009437)2.60433215
162regulation of cAMP-dependent protein kinase activity (GO:2000479)2.60392863
163synaptic transmission, cholinergic (GO:0007271)2.60367790
164linoleic acid metabolic process (GO:0043651)2.59280095
165response to isoquinoline alkaloid (GO:0014072)2.58327319
166membrane depolarization during action potential (GO:0086010)2.57782311
167epithelial cilium movement (GO:0003351)2.56633872
168long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.56429059
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56387570
170NADPH regeneration (GO:0006740)2.55973690
171regulation of establishment of cell polarity (GO:2000114)2.54454838
172positive regulation of lipid catabolic process (GO:0050996)2.53972143
173cellular response to epinephrine stimulus (GO:0071872)2.53636525
174long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.53158484
175axoneme assembly (GO:0035082)2.53034365
176meiotic chromosome segregation (GO:0045132)2.52698425
177protein K48-linked deubiquitination (GO:0071108)2.51908410
178positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.50658037
179regulation of lipid storage (GO:0010883)2.50545858
180positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.49224991
181cyclic nucleotide catabolic process (GO:0009214)2.49096826
182cilium organization (GO:0044782)2.48223656
183signal peptide processing (GO:0006465)2.48182061
184urinary tract smooth muscle contraction (GO:0014848)2.47172039
185regulation of pigment cell differentiation (GO:0050932)2.46346182
186regulation of telomere maintenance (GO:0032204)2.46260049
187preassembly of GPI anchor in ER membrane (GO:0016254)2.45756545
188purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.43233012
1893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.43233012
190rRNA catabolic process (GO:0016075)2.43149795
191transmission of nerve impulse (GO:0019226)2.43057514
192cilium assembly (GO:0042384)2.42733438
193endoderm formation (GO:0001706)2.42677149
194rhodopsin mediated signaling pathway (GO:0016056)2.41044264
195drug catabolic process (GO:0042737)2.39744088
196cilium movement (GO:0003341)2.38836335
197cilium morphogenesis (GO:0060271)2.38001474
198basic amino acid transport (GO:0015802)2.37929739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.88210264
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.00221863
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.49633794
4ZNF274_21170338_ChIP-Seq_K562_Hela4.12508909
5EZH2_22144423_ChIP-Seq_EOC_Human3.81392276
6VDR_22108803_ChIP-Seq_LS180_Human3.42121653
7CLOCK_20551151_ChIP-Seq_293T_Human3.20911698
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98324246
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.92999407
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82997822
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.71853538
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37265043
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.33868666
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31678923
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.29210974
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21606661
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15765596
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15000810
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.10223966
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99464035
21EWS_26573619_Chip-Seq_HEK293_Human1.97729500
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.94473226
23TAF15_26573619_Chip-Seq_HEK293_Human1.94082671
24ER_23166858_ChIP-Seq_MCF-7_Human1.91180007
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89872799
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.88448734
27* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85279786
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81651398
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.78801661
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75619866
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75348316
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.74941208
33IGF1R_20145208_ChIP-Seq_DFB_Human1.72667881
34P300_19829295_ChIP-Seq_ESCs_Human1.72021076
35FUS_26573619_Chip-Seq_HEK293_Human1.70825375
36STAT3_23295773_ChIP-Seq_U87_Human1.69343074
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69260404
38PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.68386082
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.67825828
40REST_21632747_ChIP-Seq_MESCs_Mouse1.64755992
41* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63271169
42* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63271169
43IRF1_19129219_ChIP-ChIP_H3396_Human1.62482558
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61866174
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61826159
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.60169098
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59805825
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58834603
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58834603
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58669238
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58669238
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57870322
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57689658
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55877179
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.53612334
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52077982
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51826078
58BCAT_22108803_ChIP-Seq_LS180_Human1.51280476
59PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.50718551
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.50047246
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49626639
62TP53_16413492_ChIP-PET_HCT116_Human1.49436935
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48529723
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46011468
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45285748
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45208941
67* TCF4_23295773_ChIP-Seq_U87_Human1.44876488
68* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44225537
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43559709
70AR_25329375_ChIP-Seq_VCAP_Human1.42162285
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38501382
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38294185
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38017120
74AR_21572438_ChIP-Seq_LNCaP_Human1.37757048
75TP53_22573176_ChIP-Seq_HFKS_Human1.35981338
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34765363
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34490004
78SMAD4_21799915_ChIP-Seq_A2780_Human1.33754561
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.33315135
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33252113
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32718340
82KDM2B_26808549_Chip-Seq_K562_Human1.32141030
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30893875
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.28781571
85GBX2_23144817_ChIP-Seq_PC3_Human1.27602735
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.27391296
87CBP_20019798_ChIP-Seq_JUKART_Human1.25195450
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25195450
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24769433
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23917767
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20902737
92RXR_22108803_ChIP-Seq_LS180_Human1.20572637
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19905640
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.18799120
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18799120
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18328439
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18243248
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.18229087
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17971791
100RUNX2_22187159_ChIP-Seq_PCA_Human1.17704259
101TCF4_22108803_ChIP-Seq_LS180_Human1.17636299
102ERA_21632823_ChIP-Seq_H3396_Human1.17587467
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17147802
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16421928
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.16088711
106RNF2_27304074_Chip-Seq_NSC_Mouse1.15475845
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.14861259
108HOXB7_26014856_ChIP-Seq_BT474_Human1.14609478
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13240890
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11907042
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11704039
112SOX2_19829295_ChIP-Seq_ESCs_Human1.11647426
113NANOG_19829295_ChIP-Seq_ESCs_Human1.11647426
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11617936
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.11578164
116* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10887724
117ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10875490
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10479735
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10354787
120AHR_22903824_ChIP-Seq_MCF-7_Human1.10223065
121* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08414449
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08000901
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07928222
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07857920
125DROSHA_22980978_ChIP-Seq_HELA_Human1.07413497
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07081718
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06531011
128NCOR_22424771_ChIP-Seq_293T_Human1.06021623
129WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05744528
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.05583786
131ZNF263_19887448_ChIP-Seq_K562_Human1.04399866
132JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04017202
133SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03722056
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03633305
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02328246
136TP63_19390658_ChIP-ChIP_HaCaT_Human1.02081926
137CJUN_26792858_Chip-Seq_BT549_Human1.01714942
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01439069
139MYC_18940864_ChIP-ChIP_HL60_Human1.00039425
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.99805973
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98852184
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98655703
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98049156
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.97581105
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97121944
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.96726123
147KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96427799
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96315415
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.95947661
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94794488
151JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94415165
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94366360
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.94064626
154SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93701257
155WDR5_24793694_ChIP-Seq_LNCAP_Human0.93671706
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93395032
157SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93077512
158TAF2_19829295_ChIP-Seq_ESCs_Human0.93032976
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92598306
160RNF2_27304074_Chip-Seq_ESCs_Mouse0.91344569
161EZH2_27304074_Chip-Seq_ESCs_Mouse0.90474174
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.89927502
163CREB1_26743006_Chip-Seq_LNCaP_Human0.89764623
164FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89433170
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.88566799
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87218512
167ATF3_27146783_Chip-Seq_COLON_Human0.86451112
168KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85994877
169CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85899468
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85679223
171SMAD_19615063_ChIP-ChIP_OVARY_Human0.85489959
172SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84655751
173MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84375253
174TP53_18474530_ChIP-ChIP_U2OS_Human0.84068084
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83330841
176TP53_22127205_ChIP-Seq_IMR90_Human0.83000909
177TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82794113
178KLF5_25053715_ChIP-Seq_YYC3_Human0.82316432
179TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81368609
180SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80820219
181LXR_22292898_ChIP-Seq_THP-1_Human0.79798498
182RACK7_27058665_Chip-Seq_MCF-7_Human0.79448109
183NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78260507
184EZH2_27294783_Chip-Seq_ESCs_Mouse0.78159868
185KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77045201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.67312128
2MP0004185_abnormal_adipocyte_glucose4.24508827
3MP0004130_abnormal_muscle_cell4.05345718
4MP0005670_abnormal_white_adipose4.00172016
5MP0003705_abnormal_hypodermis_morpholog3.66013081
6MP0003195_calcinosis3.51799577
7MP0000569_abnormal_digit_pigmentation3.41189018
8MP0005666_abnormal_adipose_tissue3.18476507
9MP0005503_abnormal_tendon_morphology3.11865492
10MP0005623_abnormal_meninges_morphology2.90077104
11MP0003136_yellow_coat_color2.90025149
12MP0003646_muscle_fatigue2.76671332
13MP0001968_abnormal_touch/_nociception2.72017279
14MP0003221_abnormal_cardiomyocyte_apopto2.68550419
15MP0004272_abnormal_basement_membrane2.67058048
16MP0002139_abnormal_hepatobiliary_system2.57166365
17MP0001661_extended_life_span2.53635348
18MP0004043_abnormal_pH_regulation2.49130791
19MP0001986_abnormal_taste_sensitivity2.48011619
20MP0005275_abnormal_skin_tensile2.46262099
21MP0009046_muscle_twitch2.44544906
22MP0005375_adipose_tissue_phenotype2.37300271
23MP0005551_abnormal_eye_electrophysiolog2.37155827
24MP0005360_urolithiasis2.35820848
25MP0000003_abnormal_adipose_tissue2.26960177
26MP0002877_abnormal_melanocyte_morpholog2.21360126
27MP0000013_abnormal_adipose_tissue2.09862358
28MP0008877_abnormal_DNA_methylation2.08998085
29MP0009745_abnormal_behavioral_response2.08908491
30MP0002736_abnormal_nociception_after2.05276590
31MP0005174_abnormal_tail_pigmentation2.01241431
32MP0002060_abnormal_skin_morphology2.00601266
33MP0009780_abnormal_chondrocyte_physiolo1.91994909
34MP0004142_abnormal_muscle_tone1.90894385
35MP0008872_abnormal_physiological_respon1.89651154
36MP0002876_abnormal_thyroid_physiology1.86638788
37MP0002735_abnormal_chemical_nociception1.85490711
38MP0002653_abnormal_ependyma_morphology1.81306502
39MP0003283_abnormal_digestive_organ1.79525977
40MP0004133_heterotaxia1.78810779
41MP0010329_abnormal_lipoprotein_level1.78242076
42MP0002102_abnormal_ear_morphology1.78174472
43MP0002638_abnormal_pupillary_reflex1.76064120
44MP0008875_abnormal_xenobiotic_pharmacok1.69476279
45MP0002971_abnormal_brown_adipose1.69088682
46MP0001485_abnormal_pinna_reflex1.68438109
47MP0010234_abnormal_vibrissa_follicle1.67294070
48MP0001501_abnormal_sleep_pattern1.67119742
49MP0005645_abnormal_hypothalamus_physiol1.66087855
50MP0003045_fibrosis1.59207277
51MP0004147_increased_porphyrin_level1.59164246
52MP0002272_abnormal_nervous_system1.58014042
53MP0003890_abnormal_embryonic-extraembry1.55316437
54MP0002064_seizures1.54379988
55MP0005646_abnormal_pituitary_gland1.52361220
56MP0000383_abnormal_hair_follicle1.47336285
57MP0002938_white_spotting1.45931936
58MP0009384_cardiac_valve_regurgitation1.45927878
59MP0002572_abnormal_emotion/affect_behav1.45583619
60MP0005076_abnormal_cell_differentiation1.44570040
61MP0004858_abnormal_nervous_system1.43804355
62MP0001486_abnormal_startle_reflex1.43265696
63MP0000631_abnormal_neuroendocrine_gland1.42424861
64MP0004145_abnormal_muscle_electrophysio1.41127723
65MP0004742_abnormal_vestibular_system1.40884173
66MP0006292_abnormal_olfactory_placode1.40482729
67MP0006276_abnormal_autonomic_nervous1.40316939
68MP0002067_abnormal_sensory_capabilities1.38874723
69MP0005334_abnormal_fat_pad1.36717687
70MP0005253_abnormal_eye_physiology1.36253450
71MP0002557_abnormal_social/conspecific_i1.35369292
72MP0005423_abnormal_somatic_nervous1.34566383
73MP0002928_abnormal_bile_duct1.33293295
74MP0002160_abnormal_reproductive_system1.31420498
75MP0004924_abnormal_behavior1.29110079
76MP0005386_behavior/neurological_phenoty1.29110079
77MP0001970_abnormal_pain_threshold1.29036533
78MP0002063_abnormal_learning/memory/cond1.28873503
79MP0002733_abnormal_thermal_nociception1.28679847
80MP0003635_abnormal_synaptic_transmissio1.27501286
81MP0005171_absent_coat_pigmentation1.27250401
82MP0005508_abnormal_skeleton_morphology1.26223729
83MP0001177_atelectasis1.24976911
84MP0002108_abnormal_muscle_morphology1.24564718
85MP0005397_hematopoietic_system_phenotyp1.24311551
86MP0001545_abnormal_hematopoietic_system1.24311551
87MP0002896_abnormal_bone_mineralization1.23590849
88MP0002118_abnormal_lipid_homeostasis1.23363470
89MP0009115_abnormal_fat_cell1.22506572
90MP0002168_other_aberrant_phenotype1.21857229
91MP0005365_abnormal_bile_salt1.21031616
92MP0005389_reproductive_system_phenotype1.20321689
93MP0001299_abnormal_eye_distance/1.19296222
94MP0001958_emphysema1.16503677
95MP0010386_abnormal_urinary_bladder1.16009728
96MP0003787_abnormal_imprinting1.14964269
97MP0003011_delayed_dark_adaptation1.14466680
98MP0001849_ear_inflammation1.14231465
99MP0003880_abnormal_central_pattern1.12000554
100MP0003252_abnormal_bile_duct1.11281493
101MP0006072_abnormal_retinal_apoptosis1.11241959
102MP0000538_abnormal_urinary_bladder1.10735233
103MP0003191_abnormal_cellular_cholesterol1.10612671
104MP0003119_abnormal_digestive_system1.08764432
105MP0004197_abnormal_fetal_growth/weight/1.06427728
106MP0001919_abnormal_reproductive_system1.05746358
107MP0000778_abnormal_nervous_system1.04590487
108MP0005195_abnormal_posterior_eye1.03706188
109MP0005448_abnormal_energy_balance1.03701084
110MP0002734_abnormal_mechanical_nocicepti1.03409842
111MP0005332_abnormal_amino_acid1.02629149
112MP0004859_abnormal_synaptic_plasticity1.00602111
113MP0003122_maternal_imprinting0.99752837
114MP0009250_abnormal_appendicular_skeleto0.97925877
115MP0002089_abnormal_postnatal_growth/wei0.97919487
116MP0001502_abnormal_circadian_rhythm0.97772302
117MP0000230_abnormal_systemic_arterial0.96764244
118MP0000428_abnormal_craniofacial_morphol0.96445966
119MP0010352_gastrointestinal_tract_polyps0.95216538
120MP0000026_abnormal_inner_ear0.94624076
121MP0010307_abnormal_tumor_latency0.93767895
122MP0002234_abnormal_pharynx_morphology0.93383129
123MP0001324_abnormal_eye_pigmentation0.93360914
124MP0003137_abnormal_impulse_conducting0.92537046
125MP0001664_abnormal_digestion0.90627272
126MP0003959_abnormal_lean_body0.89962465
127MP0000470_abnormal_stomach_morphology0.89827895
128MP0002095_abnormal_skin_pigmentation0.89205454
129MP0002970_abnormal_white_adipose0.88971786
130MP0002752_abnormal_somatic_nervous0.88451775
131MP0006138_congestive_heart_failure0.88144016
132MP0002837_dystrophic_cardiac_calcinosis0.84788119
133MP0003453_abnormal_keratinocyte_physiol0.84223896
134MP0003718_maternal_effect0.83221896
135MP0005167_abnormal_blood-brain_barrier0.83175701
136MP0005385_cardiovascular_system_phenoty0.83126758
137MP0001544_abnormal_cardiovascular_syste0.83126758
138MP0005248_abnormal_Harderian_gland0.83035148
139MP0002111_abnormal_tail_morphology0.81286345
140MP0005164_abnormal_response_to0.80616287
141MP0003878_abnormal_ear_physiology0.80114315
142MP0002796_impaired_skin_barrier0.79158796
143MP0002184_abnormal_innervation0.78936063
144MP0000609_abnormal_liver_physiology0.78468408
145MP0000751_myopathy0.77206273
146MP0003698_abnormal_male_reproductive0.76882113
147MP0004270_analgesia0.76713265
148MP0005084_abnormal_gallbladder_morpholo0.76679975
149MP0008775_abnormal_heart_ventricle0.76601042
150MP0003091_abnormal_cell_migration0.76400946
151MP0002751_abnormal_autonomic_nervous0.76287789
152MP0001963_abnormal_hearing_physiology0.76172895
153MP0008057_abnormal_DNA_replication0.76104264
154MP0003755_abnormal_palate_morphology0.75862937
155MP0000372_irregular_coat_pigmentation0.75671007
156MP0002882_abnormal_neuron_morphology0.75652900
157MP0000955_abnormal_spinal_cord0.75191056
158MP0000462_abnormal_digestive_system0.74528041
159MP0000647_abnormal_sebaceous_gland0.74282337
160MP0004134_abnormal_chest_morphology0.74117935
161MP0005535_abnormal_body_temperature0.73486281
162MP0010771_integument_phenotype0.73096005
163MP0000639_abnormal_adrenal_gland0.72206128
164MP0000733_abnormal_muscle_development0.72118357
165MP0009672_abnormal_birth_weight0.71677179
166MP0002115_abnormal_skeleton_extremities0.71646993
167MP0003329_amyloid_beta_deposits0.71485836
168MP0002090_abnormal_vision0.71308180
169MP0000163_abnormal_cartilage_morphology0.70754625
170MP0000427_abnormal_hair_cycle0.70642434
171MP0000566_synostosis0.69931600
172MP0005085_abnormal_gallbladder_physiolo0.69820700
173MP0001756_abnormal_urination0.68679464
174MP0002078_abnormal_glucose_homeostasis0.68315548
175MP0002909_abnormal_adrenal_gland0.67924834
176MP0005058_abnormal_lysosome_morphology0.67108103
177MP0003115_abnormal_respiratory_system0.65167117
178MP0004885_abnormal_endolymph0.64462700
179MP0002282_abnormal_trachea_morphology0.63159083
180MP0005197_abnormal_uvea_morphology0.63068140
181MP0002249_abnormal_larynx_morphology0.62537893
182MP0003279_aneurysm0.61788091
183MP0008961_abnormal_basal_metabolism0.61024293
184MP0001188_hyperpigmentation0.57408136
185MP0003937_abnormal_limbs/digits/tail_de0.57378398
186MP0003942_abnormal_urinary_system0.56675178
187MP0005377_hearing/vestibular/ear_phenot0.56136687

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)8.05301492
2Ankle contracture (HP:0006466)7.36115805
3Follicular hyperkeratosis (HP:0007502)5.70283521
4Slender build (HP:0001533)5.28104555
5Protrusio acetabuli (HP:0003179)5.11648678
6Type 1 muscle fiber predominance (HP:0003803)4.91101356
7Neoplasm of the adrenal gland (HP:0100631)4.71825188
8Pancreatic cysts (HP:0001737)4.67886475
9Abnormality of midbrain morphology (HP:0002418)4.43951556
10Molar tooth sign on MRI (HP:0002419)4.43951556
11Pancreatic fibrosis (HP:0100732)4.14048885
12Genetic anticipation (HP:0003743)4.09990066
13Congenital stationary night blindness (HP:0007642)4.08967707
14True hermaphroditism (HP:0010459)3.95658418
15Spinal rigidity (HP:0003306)3.94461093
16Oligomenorrhea (HP:0000876)3.92952390
17Premature rupture of membranes (HP:0001788)3.86541781
18Birth length less than 3rd percentile (HP:0003561)3.85093311
19Broad metatarsal (HP:0001783)3.81238997
20Hyperventilation (HP:0002883)3.75878044
21Abnormality of alanine metabolism (HP:0010916)3.65897435
22Hyperalaninemia (HP:0003348)3.65897435
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.65897435
24Nephronophthisis (HP:0000090)3.60785575
25Neonatal short-limb short stature (HP:0008921)3.50997863
26Increased variability in muscle fiber diameter (HP:0003557)3.44888187
27Protruding tongue (HP:0010808)3.42162549
28Cervical subluxation (HP:0003308)3.41167665
29Patellar aplasia (HP:0006443)3.34818454
30Epidermoid cyst (HP:0200040)3.32147222
31Progressive cerebellar ataxia (HP:0002073)3.31104662
32Buphthalmos (HP:0000557)3.27320619
33Clumsiness (HP:0002312)3.23787552
34Type II lissencephaly (HP:0007260)3.20631520
35Mildly elevated creatine phosphokinase (HP:0008180)3.20139286
36Attenuation of retinal blood vessels (HP:0007843)3.18849847
37Hyperlipoproteinemia (HP:0010980)3.18157022
38Skin nodule (HP:0200036)3.17489073
39Tubular atrophy (HP:0000092)3.17341460
40Turricephaly (HP:0000262)3.15133039
41Shallow orbits (HP:0000586)3.14603736
42Aplasia/Hypoplasia of the patella (HP:0006498)3.13784963
43Abnormality of the renal medulla (HP:0100957)3.13431894
44Large for gestational age (HP:0001520)3.12801150
45Hypoventilation (HP:0002791)3.08694886
46Inability to walk (HP:0002540)3.06393010
47Cystic liver disease (HP:0006706)3.05060106
48Abnormality of the renal cortex (HP:0011035)2.99855115
49Myocardial infarction (HP:0001658)2.92667645
50Gaze-evoked nystagmus (HP:0000640)2.89797879
51Chronic hepatic failure (HP:0100626)2.88065543
52Abnormal drinking behavior (HP:0030082)2.85798115
53Polydipsia (HP:0001959)2.85798115
54Acanthosis nigricans (HP:0000956)2.84148363
55Cerebral aneurysm (HP:0004944)2.77790808
56Abnormality of skeletal muscle fiber size (HP:0012084)2.73015140
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.71687889
58Concave nail (HP:0001598)2.70528227
59Xanthomatosis (HP:0000991)2.70242260
60Pendular nystagmus (HP:0012043)2.61962887
61Torticollis (HP:0000473)2.58905265
62Enlarged penis (HP:0000040)2.58549201
63Soft skin (HP:0000977)2.56659824
64Hypoalphalipoproteinemia (HP:0003233)2.56346486
65Atrophic scars (HP:0001075)2.56076202
66Broad-based gait (HP:0002136)2.53761212
67Progressive inability to walk (HP:0002505)2.52121902
68Decreased circulating renin level (HP:0003351)2.49936338
69Cerebellar dysplasia (HP:0007033)2.49189553
70Limb-girdle muscle weakness (HP:0003325)2.47336764
71Chorioretinal atrophy (HP:0000533)2.45388989
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.44760059
73Medial flaring of the eyebrow (HP:0010747)2.44570932
74Abnormality of the renal collecting system (HP:0004742)2.42314486
75Peritonitis (HP:0002586)2.42274364
76Duplicated collecting system (HP:0000081)2.40498127
77Furrowed tongue (HP:0000221)2.39936073
78Lissencephaly (HP:0001339)2.39653840
79Complement deficiency (HP:0004431)2.36843878
80Abnormality of the pons (HP:0007361)2.36135028
81Hypoplasia of the pons (HP:0012110)2.34722691
82Abolished electroretinogram (ERG) (HP:0000550)2.34572033
83Increased connective tissue (HP:0009025)2.34385138
84Decreased central vision (HP:0007663)2.32962462
85Abnormality of serine family amino acid metabolism (HP:0010894)2.32084898
86Abnormality of glycine metabolism (HP:0010895)2.32084898
87Bladder diverticulum (HP:0000015)2.31912862
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.30981821
89Absent/shortened dynein arms (HP:0200106)2.30981821
90Humeroradial synostosis (HP:0003041)2.30275843
91Synostosis involving the elbow (HP:0003938)2.30275843
92Melanoma (HP:0002861)2.28903383
93Craniofacial dystonia (HP:0012179)2.28105491
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27503623
95Sclerocornea (HP:0000647)2.27073633
96Congenital, generalized hypertrichosis (HP:0004540)2.26338290
97Congenital glaucoma (HP:0001087)2.22398275
98Increased corneal curvature (HP:0100692)2.20660671
99Keratoconus (HP:0000563)2.20660671
100Anencephaly (HP:0002323)2.20499835
101Vertebral compression fractures (HP:0002953)2.20141796
102Increased neuronal autofluorescent lipopigment (HP:0002074)2.20042246
103Hyperextensible skin (HP:0000974)2.18136183
104Severe muscular hypotonia (HP:0006829)2.17410606
105Polyuria (HP:0000103)2.17308094
106Generalized amyotrophy (HP:0003700)2.16441016
107Congenital hepatic fibrosis (HP:0002612)2.15016063
108Wrist flexion contracture (HP:0001239)2.13025752
109Fair hair (HP:0002286)2.12221158
110Focal dystonia (HP:0004373)2.11718350
111Breast hypoplasia (HP:0003187)2.11668022
112Fragile skin (HP:0001030)2.10314913
113Coronal craniosynostosis (HP:0004440)2.10127520
114Bony spicule pigmentary retinopathy (HP:0007737)2.09392147
115Termporal pattern (HP:0011008)2.08491333
116Insidious onset (HP:0003587)2.08491333
117Aplasia/Hypoplasia of the tongue (HP:0010295)2.08101487
118Tachypnea (HP:0002789)2.07669095
119Nausea (HP:0002018)2.07636456
120Ketosis (HP:0001946)2.07092065
121Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03800173
122Hyperglycinuria (HP:0003108)2.02966814
123Febrile seizures (HP:0002373)2.02313838
124Hypertriglyceridemia (HP:0002155)2.02045395
125Genu recurvatum (HP:0002816)2.01365214
126Stomach cancer (HP:0012126)2.01080845
127Gait imbalance (HP:0002141)1.99901227
128Hyperuricemia (HP:0002149)1.98383161
129Increased purine levels (HP:0004368)1.98383161
130Partial agenesis of the corpus callosum (HP:0001338)1.97974349
131Abnormal respiratory epithelium morphology (HP:0012253)1.97971625
132Abnormal respiratory motile cilium morphology (HP:0005938)1.97971625
133Cupped ribs (HP:0000887)1.96961545
134Hypoplastic ischia (HP:0003175)1.96339393
135Male pseudohermaphroditism (HP:0000037)1.95862033
136Elbow flexion contracture (HP:0002987)1.95461651
137Deviation of the hallux (HP:0010051)1.94865723
138Abnormality of dentin (HP:0010299)1.94759334
139Abnormal biliary tract physiology (HP:0012439)1.94304427
140Bile duct proliferation (HP:0001408)1.94304427
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94041861
142Abnormality of the middle phalanges of the toes (HP:0010183)1.92675514
143Cutaneous melanoma (HP:0012056)1.92516041
144Mild short stature (HP:0003502)1.92300861
145Ketoacidosis (HP:0001993)1.92286269
146Hyperglycinemia (HP:0002154)1.89657455
147Absent speech (HP:0001344)1.89392102
148Blue sclerae (HP:0000592)1.88873100
149Rib fusion (HP:0000902)1.88563025
150Congenital primary aphakia (HP:0007707)1.87864040
151Exostoses (HP:0100777)1.87464824
152Congenital sensorineural hearing impairment (HP:0008527)1.86520742
153Widely spaced teeth (HP:0000687)1.85680551
154Bulbous nose (HP:0000414)1.83326629
155Osteoarthritis (HP:0002758)1.80979525
156Small hand (HP:0200055)1.80359962
157Hypercholesterolemia (HP:0003124)1.79751061
158Nephrogenic diabetes insipidus (HP:0009806)1.79291525
159Reduced subcutaneous adipose tissue (HP:0003758)1.78651501
160Aortic dissection (HP:0002647)1.78243464
161Bronchomalacia (HP:0002780)1.77854627
162Abnormal rod and cone electroretinograms (HP:0008323)1.77539801
163Toxemia of pregnancy (HP:0100603)1.75838926
164Narrow nasal bridge (HP:0000446)1.75511155
165Abnormal gallbladder physiology (HP:0012438)1.75504103
166Cholecystitis (HP:0001082)1.75504103
167Lymphangioma (HP:0100764)1.72749103
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.72178236
169Postaxial foot polydactyly (HP:0001830)1.71498671
170Hallux valgus (HP:0001822)1.71338276
171Mitral valve prolapse (HP:0001634)1.70708320
172Insulin-resistant diabetes mellitus (HP:0000831)1.69514971
173Macroglossia (HP:0000158)1.68976674
174Biconcave vertebral bodies (HP:0004586)1.68885707
175Dandy-Walker malformation (HP:0001305)1.68747301
176Generalized hypopigmentation of hair (HP:0011358)1.68458820
177Preaxial hand polydactyly (HP:0001177)1.67848696
178Abnormal urine output (HP:0012590)1.67633952
179Deep venous thrombosis (HP:0002625)1.66293728
180Astrocytoma (HP:0009592)1.66148012
181Abnormality of the astrocytes (HP:0100707)1.66148012
182Hand muscle atrophy (HP:0009130)1.65778588
183Mesangial abnormality (HP:0001966)1.65438556
184Joint laxity (HP:0001388)1.65332375
185Hypoplastic iliac wings (HP:0002866)1.65218398
186Cerebral inclusion bodies (HP:0100314)1.64720244
187Renal cortical cysts (HP:0000803)1.64310398
188Increased number of teeth (HP:0011069)1.64303240
189Ectopic kidney (HP:0000086)1.63872497
190Abnormal ciliary motility (HP:0012262)1.63262878
191Abnormality of the ischium (HP:0003174)1.63051780
192Absent thumb (HP:0009777)1.62728985
193Abnormality of complement system (HP:0005339)1.62548874
194Abnormality of purine metabolism (HP:0004352)1.62393198
195Protruding ear (HP:0000411)1.62055816
196Upper limb amyotrophy (HP:0009129)1.61657585
197Distal upper limb amyotrophy (HP:0007149)1.61657585
198Polygenic inheritance (HP:0010982)1.60291777
199Abnormality of the lower motor neuron (HP:0002366)1.60200565
200Abnormal delivery (HP:0001787)1.58707861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.17431196
2TRIB34.07000266
3BMPR1B4.03362926
4PKN23.86286921
5ADRBK23.57410289
6TLK13.17684582
7SIK13.03158233
8DAPK33.01834484
9ERN13.01202697
10BCKDK2.88253070
11FGFR22.75182987
12PDGFRA2.72443571
13DDR22.70610078
14LATS22.67369297
15ZAK2.53057840
16INSRR2.40592564
17MKNK22.32456061
18GRK12.27978267
19FRK2.16449092
20KSR22.00197160
21CASK1.96881797
22DAPK21.96003523
23TAOK31.91930203
24TGFBR11.79098237
25PAK61.78274430
26MAP2K11.75635516
27RIPK11.73509563
28NTRK11.66809801
29CDK91.65539458
30MAPK151.61242478
31PINK11.60506490
32MAPK131.59953650
33ADRBK11.59484576
34WNK31.57031843
35CAMKK21.56512949
36FLT31.54980989
37BMX1.48052194
38PAK31.44565762
39PNCK1.42895326
40LATS11.40443358
41NUAK11.39205054
42FGFR11.37332058
43RPS6KB11.35044379
44PIM11.32312517
45CAMK1D1.30699171
46PDK31.26908786
47PDK41.26908786
48WNK41.25165817
49ICK1.24974283
50CAMKK11.23899024
51KSR11.22371358
52PIK3CA1.21569755
53CSNK1A1L1.21206126
54RET1.20984963
55CAMK1G1.19295784
56MET1.17198473
57MAP2K41.10910723
58MAP3K91.06234813
59AKT31.05532244
60MST1R1.05316237
61SIK21.05127815
62MAP4K21.04750057
63OXSR11.03373011
64EPHB21.00809281
65TNIK0.99318898
66CSNK1G10.99309716
67PDGFRB0.96750282
68MINK10.96725216
69NEK20.96319780
70MUSK0.94783706
71PTK60.92436334
72MKNK10.90944767
73MARK10.87277460
74CSNK1G20.86416224
75EPHB10.83099690
76TYRO30.82088630
77CSNK1G30.81474547
78PAK20.81088708
79MAPKAPK30.78226855
80WNK10.78163167
81SCYL20.78040375
82MAP2K60.77506417
83PTK20.77164785
84LMTK20.76340034
85PRKCH0.75692618
86PTK2B0.74613632
87RPS6KA60.70092520
88MAP3K40.69556360
89NTRK30.68977512
90TRPM70.68841449
91CHUK0.68836980
92NTRK20.68684583
93EEF2K0.68575569
94FER0.66230578
95MELK0.66148899
96FGFR30.65124326
97MTOR0.64856967
98ERBB40.64841208
99CAMK10.63941787
100PLK20.63914022
101DYRK20.63784117
102STK390.61693455
103TXK0.60914899
104PRKCE0.60439636
105MAP3K20.60328350
106CSNK1D0.60058009
107RPS6KA50.59971489
108PKN10.59455979
109RAF10.58350436
110STK30.55846743
111STK110.55534272
112LIMK10.54852300
113CDK50.54278169
114PRKCZ0.54234130
115SGK20.53944119
116ROCK20.52833510
117PRKCQ0.51464599
118MAP2K70.51384364
119STK38L0.51126490
120ABL20.50887477
121PRKAA20.50710470
122FGFR40.49489396
123BRSK20.49480531
124MAPKAPK50.48824875
125CAMK2A0.47611722
126IKBKB0.47375654
127IRAK10.47259905
128MARK20.46556818
129ROCK10.46246057
130STK380.45344586
131PDPK10.45326349
132OBSCN0.45161403
133LRRK20.44979454
134SRC0.44533871
135ARAF0.44207549
136ERBB20.43875386
137MAPK110.42835931
138ABL10.42729180
139CDK140.42565498
140PDK20.42334160
141CHEK20.42319456
142TIE10.41465866
143INSR0.41077869
144MAPKAPK20.39651897
145PHKG20.39594347
146PHKG10.39594347
147KIT0.39541594
148ILK0.38956371
149MAP3K70.38885081
150CAMK40.38783722
151PRKCG0.38141857
152WEE10.37435979
153TTN0.36859743
154NEK10.36801723
155TEC0.36655423
156PRKACA0.35779861
157PDK10.35335983
158ATR0.35056646
159PRKAA10.34971826
160SGK2230.34790943
161SGK4940.34790943
162ALK0.33800324
163NLK0.32897840
164MAP3K110.31007992
165DYRK1A0.29868993
166PIK3CG0.29762188
167CSNK1A10.27554455
168TNK20.26889639
169VRK10.26165868
170PRKCA0.24831287
171SGK10.23288407

Predicted pathways (KEGG)

RankGene SetZ-score
1Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.28751709
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.16880635
3PPAR signaling pathway_Homo sapiens_hsa033202.91418054
4Linoleic acid metabolism_Homo sapiens_hsa005912.82232489
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81247376
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.78113435
7Propanoate metabolism_Homo sapiens_hsa006402.71798709
8Phototransduction_Homo sapiens_hsa047442.69187659
9Nicotine addiction_Homo sapiens_hsa050332.58077151
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36316366
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35021339
12Butanoate metabolism_Homo sapiens_hsa006502.33795617
13Selenocompound metabolism_Homo sapiens_hsa004502.32821454
14Bladder cancer_Homo sapiens_hsa052192.28260316
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.27170295
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24326615
17Fatty acid metabolism_Homo sapiens_hsa012122.22810065
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.22476358
19Fatty acid degradation_Homo sapiens_hsa000712.22263551
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21369366
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.09494352
22Nitrogen metabolism_Homo sapiens_hsa009101.98412227
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97528253
24Taste transduction_Homo sapiens_hsa047421.92798521
25Homologous recombination_Homo sapiens_hsa034401.89446738
26Ether lipid metabolism_Homo sapiens_hsa005651.83998047
27ABC transporters_Homo sapiens_hsa020101.83949506
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81639837
29Glioma_Homo sapiens_hsa052141.80041681
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.73582740
31Sulfur metabolism_Homo sapiens_hsa009201.68305252
32Morphine addiction_Homo sapiens_hsa050321.63845226
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61669720
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59084305
35Fatty acid biosynthesis_Homo sapiens_hsa000611.57314978
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.55904896
37Melanoma_Homo sapiens_hsa052181.53826345
38ECM-receptor interaction_Homo sapiens_hsa045121.52348763
39beta-Alanine metabolism_Homo sapiens_hsa004101.49271554
40Fanconi anemia pathway_Homo sapiens_hsa034601.45752415
41Carbon metabolism_Homo sapiens_hsa012001.45003677
42Glycerolipid metabolism_Homo sapiens_hsa005611.43036643
43RNA polymerase_Homo sapiens_hsa030201.40713344
44Olfactory transduction_Homo sapiens_hsa047401.37797421
45Glutamatergic synapse_Homo sapiens_hsa047241.29542284
46Circadian entrainment_Homo sapiens_hsa047131.28214873
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27884812
48Protein digestion and absorption_Homo sapiens_hsa049741.24320719
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22799414
50Histidine metabolism_Homo sapiens_hsa003401.22763964
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.20137903
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.19922690
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.17903859
54Serotonergic synapse_Homo sapiens_hsa047261.17384958
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17287662
56Insulin secretion_Homo sapiens_hsa049111.16908215
57Peroxisome_Homo sapiens_hsa041461.16653464
58Pyruvate metabolism_Homo sapiens_hsa006201.14654484
59Calcium signaling pathway_Homo sapiens_hsa040201.13616612
60Chronic myeloid leukemia_Homo sapiens_hsa052201.12978531
61Tryptophan metabolism_Homo sapiens_hsa003801.12626782
62Ovarian steroidogenesis_Homo sapiens_hsa049131.12583011
63Biosynthesis of amino acids_Homo sapiens_hsa012301.12404067
64Adipocytokine signaling pathway_Homo sapiens_hsa049201.12041819
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11368656
66Phenylalanine metabolism_Homo sapiens_hsa003601.10748302
67Central carbon metabolism in cancer_Homo sapiens_hsa052301.09012510
68GABAergic synapse_Homo sapiens_hsa047271.02363713
69AMPK signaling pathway_Homo sapiens_hsa041521.02141322
70Basal transcription factors_Homo sapiens_hsa030221.00864175
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98818498
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94701993
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93809489
74One carbon pool by folate_Homo sapiens_hsa006700.93691527
75Arginine biosynthesis_Homo sapiens_hsa002200.93190347
76Prostate cancer_Homo sapiens_hsa052150.92848413
77Focal adhesion_Homo sapiens_hsa045100.92092120
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91529452
79Arachidonic acid metabolism_Homo sapiens_hsa005900.91047304
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90518329
81Salivary secretion_Homo sapiens_hsa049700.89960325
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88062032
83Retinol metabolism_Homo sapiens_hsa008300.83883292
84Dorso-ventral axis formation_Homo sapiens_hsa043200.82857075
85Fat digestion and absorption_Homo sapiens_hsa049750.80310833
86Bile secretion_Homo sapiens_hsa049760.80066319
87Vitamin digestion and absorption_Homo sapiens_hsa049770.79564635
88Proteoglycans in cancer_Homo sapiens_hsa052050.79462963
89Lysine degradation_Homo sapiens_hsa003100.79262248
90Cholinergic synapse_Homo sapiens_hsa047250.78893311
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.78633911
92Type II diabetes mellitus_Homo sapiens_hsa049300.77988652
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76782948
94Sulfur relay system_Homo sapiens_hsa041220.75818133
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74505992
96Long-term depression_Homo sapiens_hsa047300.74131980
97Cocaine addiction_Homo sapiens_hsa050300.71839851
98Oxidative phosphorylation_Homo sapiens_hsa001900.70798680
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70753488
100mTOR signaling pathway_Homo sapiens_hsa041500.70657275
101Caffeine metabolism_Homo sapiens_hsa002320.69465944
102Insulin signaling pathway_Homo sapiens_hsa049100.69224167
103Cardiac muscle contraction_Homo sapiens_hsa042600.68687356
104Tyrosine metabolism_Homo sapiens_hsa003500.67562527
105Insulin resistance_Homo sapiens_hsa049310.67031635
106Thyroid cancer_Homo sapiens_hsa052160.66673327
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65969889
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64948329
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64672939
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64574068
111Renal cell carcinoma_Homo sapiens_hsa052110.64308691
112Gastric acid secretion_Homo sapiens_hsa049710.62714370
113Dopaminergic synapse_Homo sapiens_hsa047280.61708319
114Starch and sucrose metabolism_Homo sapiens_hsa005000.60960785
115Amoebiasis_Homo sapiens_hsa051460.60226449
116Steroid biosynthesis_Homo sapiens_hsa001000.58917768
117cAMP signaling pathway_Homo sapiens_hsa040240.57788248
118Oxytocin signaling pathway_Homo sapiens_hsa049210.57032207
119Endometrial cancer_Homo sapiens_hsa052130.56187708
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54784482
121Mineral absorption_Homo sapiens_hsa049780.53827104
122Fatty acid elongation_Homo sapiens_hsa000620.52803997
123MicroRNAs in cancer_Homo sapiens_hsa052060.52417840
124Basal cell carcinoma_Homo sapiens_hsa052170.50288861
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50058740
126Vibrio cholerae infection_Homo sapiens_hsa051100.49751083
127FoxO signaling pathway_Homo sapiens_hsa040680.49657842
128Non-small cell lung cancer_Homo sapiens_hsa052230.48448786
129Glucagon signaling pathway_Homo sapiens_hsa049220.48353294
130Pancreatic cancer_Homo sapiens_hsa052120.48315934
131Synaptic vesicle cycle_Homo sapiens_hsa047210.47053252
132Chemical carcinogenesis_Homo sapiens_hsa052040.46851991
133RNA degradation_Homo sapiens_hsa030180.46481064
134Estrogen signaling pathway_Homo sapiens_hsa049150.45237898
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45189228
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.45079754
137Circadian rhythm_Homo sapiens_hsa047100.44169668
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43030683
139Huntingtons disease_Homo sapiens_hsa050160.42931677
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42901038
141Complement and coagulation cascades_Homo sapiens_hsa046100.42604589
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41417845
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.40989287
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40625553
145Amphetamine addiction_Homo sapiens_hsa050310.39552339
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.38791056
147Hedgehog signaling pathway_Homo sapiens_hsa043400.38531754
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38417887
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38298088
150Asthma_Homo sapiens_hsa053100.37350486
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36907574
152p53 signaling pathway_Homo sapiens_hsa041150.36637394
153MAPK signaling pathway_Homo sapiens_hsa040100.36470202
154ErbB signaling pathway_Homo sapiens_hsa040120.35631497
155GnRH signaling pathway_Homo sapiens_hsa049120.35205332
156Axon guidance_Homo sapiens_hsa043600.34818468
157Purine metabolism_Homo sapiens_hsa002300.33378355
158Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33068875
159Vitamin B6 metabolism_Homo sapiens_hsa007500.33000016
160Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32747673
161Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32392560
162Collecting duct acid secretion_Homo sapiens_hsa049660.31956879
163Hippo signaling pathway_Homo sapiens_hsa043900.31763363
164Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31122270
165Regulation of autophagy_Homo sapiens_hsa041400.30968404
166Parkinsons disease_Homo sapiens_hsa050120.30952564
167Gap junction_Homo sapiens_hsa045400.30314950
168Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29640680
169Metabolic pathways_Homo sapiens_hsa011000.29592971
170Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28932482
171Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26826493
172Alzheimers disease_Homo sapiens_hsa050100.25924102
173Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25765841

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