SLC35E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.38236501
2L-phenylalanine catabolic process (GO:0006559)6.38236501
3behavioral response to nicotine (GO:0035095)6.08236029
4aromatic amino acid family catabolic process (GO:0009074)6.02362062
5indole-containing compound catabolic process (GO:0042436)5.76725602
6indolalkylamine catabolic process (GO:0046218)5.76725602
7tryptophan catabolic process (GO:0006569)5.76725602
8L-phenylalanine metabolic process (GO:0006558)5.68851021
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.68851021
10tryptophan metabolic process (GO:0006568)5.52437312
11bile acid biosynthetic process (GO:0006699)5.09276284
12kynurenine metabolic process (GO:0070189)5.05675698
13pyrimidine nucleobase catabolic process (GO:0006208)4.95792662
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.94986148
15urea cycle (GO:0000050)4.64752205
16urea metabolic process (GO:0019627)4.64752205
17high-density lipoprotein particle remodeling (GO:0034375)4.64006014
18cellular biogenic amine catabolic process (GO:0042402)4.50631481
19amine catabolic process (GO:0009310)4.50631481
20bile acid metabolic process (GO:0008206)4.43182848
21tyrosine metabolic process (GO:0006570)4.38521725
22aromatic amino acid family metabolic process (GO:0009072)4.34327651
23regulation of fibrinolysis (GO:0051917)4.33922214
24regulation of cholesterol esterification (GO:0010872)4.33674592
25indolalkylamine metabolic process (GO:0006586)4.32382548
26complement activation, alternative pathway (GO:0006957)4.30397665
27regulation of protein activation cascade (GO:2000257)4.29567849
28nitrogen cycle metabolic process (GO:0071941)4.27499218
29glyoxylate metabolic process (GO:0046487)4.18391185
30nucleobase catabolic process (GO:0046113)4.09196492
31regulation of bile acid biosynthetic process (GO:0070857)4.07722311
32NAD biosynthetic process (GO:0009435)4.06117384
33negative regulation of fibrinolysis (GO:0051918)4.03321672
34reverse cholesterol transport (GO:0043691)4.03273891
35protein-lipid complex remodeling (GO:0034368)4.00952878
36macromolecular complex remodeling (GO:0034367)4.00952878
37plasma lipoprotein particle remodeling (GO:0034369)4.00952878
38coenzyme catabolic process (GO:0009109)4.00684756
39negative regulation of telomere maintenance (GO:0032205)4.00670782
40regulation of complement activation (GO:0030449)3.96505071
41cholesterol efflux (GO:0033344)3.95196407
42serine family amino acid catabolic process (GO:0009071)3.94708709
43DNA deamination (GO:0045006)3.94686092
44imidazole-containing compound metabolic process (GO:0052803)3.93091708
45postsynaptic membrane organization (GO:0001941)3.88655493
46alpha-linolenic acid metabolic process (GO:0036109)3.86482400
47bile acid and bile salt transport (GO:0015721)3.85866200
48alpha-amino acid catabolic process (GO:1901606)3.82696348
49phospholipid efflux (GO:0033700)3.81105442
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.80677291
51acylglycerol homeostasis (GO:0055090)3.79557981
52triglyceride homeostasis (GO:0070328)3.79557981
53very-low-density lipoprotein particle assembly (GO:0034379)3.77330387
54homocysteine metabolic process (GO:0050667)3.76292742
55protein carboxylation (GO:0018214)3.73797931
56peptidyl-glutamic acid carboxylation (GO:0017187)3.73797931
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73183180
58low-density lipoprotein particle remodeling (GO:0034374)3.69233525
59cellular glucuronidation (GO:0052695)3.65728598
60blood coagulation, intrinsic pathway (GO:0007597)3.65066906
61regulation of triglyceride catabolic process (GO:0010896)3.61734640
62negative regulation of lipase activity (GO:0060192)3.60844182
63gamma-aminobutyric acid transport (GO:0015812)3.57578111
64glutamate metabolic process (GO:0006536)3.51987422
65amino-acid betaine metabolic process (GO:0006577)3.50821687
66cysteine metabolic process (GO:0006534)3.50062651
67L-fucose catabolic process (GO:0042355)3.49468602
68fucose catabolic process (GO:0019317)3.49468602
69L-fucose metabolic process (GO:0042354)3.49468602
70positive regulation of oligodendrocyte differentiation (GO:0048714)3.49166017
71axonal fasciculation (GO:0007413)3.47294758
72nicotinamide nucleotide biosynthetic process (GO:0019359)3.46143160
73pyridine nucleotide biosynthetic process (GO:0019363)3.46143160
74negative regulation of cholesterol transport (GO:0032375)3.43208866
75negative regulation of sterol transport (GO:0032372)3.43208866
76drug catabolic process (GO:0042737)3.41237413
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39107741
78cellular amino acid catabolic process (GO:0009063)3.38420042
79benzene-containing compound metabolic process (GO:0042537)3.37224931
80neuron cell-cell adhesion (GO:0007158)3.37187545
81negative regulation of protein activation cascade (GO:2000258)3.37057079
82arginine metabolic process (GO:0006525)3.36854976
83activated T cell proliferation (GO:0050798)3.36746228
84plasma lipoprotein particle assembly (GO:0034377)3.34640138
85sulfur amino acid catabolic process (GO:0000098)3.33548235
86dicarboxylic acid biosynthetic process (GO:0043650)3.31556760
87intestinal cholesterol absorption (GO:0030299)3.29757794
88epithelial cilium movement (GO:0003351)3.22009157
89fatty acid elongation (GO:0030497)3.21260104
90uronic acid metabolic process (GO:0006063)3.21226591
91glucuronate metabolic process (GO:0019585)3.21226591
92indole-containing compound metabolic process (GO:0042430)3.21097403
93synaptic transmission, cholinergic (GO:0007271)3.19020036
94protein activation cascade (GO:0072376)3.18754742
95nonmotile primary cilium assembly (GO:0035058)3.16772626
96response to pheromone (GO:0019236)3.16482538
97presynaptic membrane assembly (GO:0097105)3.12040458
98very long-chain fatty acid metabolic process (GO:0000038)3.11973919
99synapse assembly (GO:0007416)3.08482187
100phospholipid homeostasis (GO:0055091)3.08065544
101startle response (GO:0001964)3.07554717
102opsonization (GO:0008228)3.07142692
103presynaptic membrane organization (GO:0097090)3.06823359
104plasma lipoprotein particle organization (GO:0071827)3.06206677
105cofactor catabolic process (GO:0051187)3.05291595
106positive regulation of lipoprotein lipase activity (GO:0051006)3.05195439
107positive regulation of triglyceride lipase activity (GO:0061365)3.05195439
108retinal ganglion cell axon guidance (GO:0031290)3.02912943
109regulation of action potential (GO:0098900)3.02260645
110complement activation, classical pathway (GO:0006958)3.01504348
111neuronal action potential (GO:0019228)2.99524408
112calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98747722
113cholesterol homeostasis (GO:0042632)2.97945937
114pyridine-containing compound biosynthetic process (GO:0072525)2.97489864
115flavonoid metabolic process (GO:0009812)2.97467670
116positive regulation of mitochondrial fission (GO:0090141)2.96485387
117regulation of telomere maintenance (GO:0032204)2.96388562
118plasma lipoprotein particle clearance (GO:0034381)2.96378552
119complement activation (GO:0006956)2.96151449
120neuron recognition (GO:0008038)2.95412263
121neural tube formation (GO:0001841)2.93455820
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92978971
123cellular ketone body metabolic process (GO:0046950)2.91548390
124auditory behavior (GO:0031223)2.90936807
125sterol homeostasis (GO:0055092)2.90831033
126protein polyglutamylation (GO:0018095)2.90507720
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89400312
128exogenous drug catabolic process (GO:0042738)2.88741647
129transmission of nerve impulse (GO:0019226)2.88051782
130negative regulation of oligodendrocyte differentiation (GO:0048715)2.87051140
131protein localization to synapse (GO:0035418)2.86927242
132cytolysis (GO:0019835)2.86568854
133organic acid catabolic process (GO:0016054)2.85611329
134carboxylic acid catabolic process (GO:0046395)2.85611329
135forebrain neuron differentiation (GO:0021879)2.85097643
136somite development (GO:0061053)2.83689604
137olfactory bulb development (GO:0021772)2.83630201
138fibrinolysis (GO:0042730)2.83512943
139cellular modified amino acid catabolic process (GO:0042219)2.82653706
140neuronal stem cell maintenance (GO:0097150)2.79675713
141spinal cord development (GO:0021510)2.79645970
142platelet dense granule organization (GO:0060155)2.79611208
143dendritic spine morphogenesis (GO:0060997)2.73764466
144protein localization to cilium (GO:0061512)2.73565895
145cilium or flagellum-dependent cell motility (GO:0001539)2.72780051
146neuron fate determination (GO:0048664)2.71902316
147cell differentiation in spinal cord (GO:0021515)2.71606456
148growth hormone secretion (GO:0030252)2.71088796
149positive regulation of growth hormone secretion (GO:0060124)2.67620548
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67065572
151mitochondrial respiratory chain complex I assembly (GO:0032981)2.67065572
152NADH dehydrogenase complex assembly (GO:0010257)2.67065572
153ubiquinone metabolic process (GO:0006743)2.66773895
154cilium movement (GO:0003341)2.66528439
155ionotropic glutamate receptor signaling pathway (GO:0035235)2.66218325
156head development (GO:0060322)2.63802652
157vocalization behavior (GO:0071625)2.62978374
158protein complex biogenesis (GO:0070271)2.61607262
159pyrimidine dimer repair (GO:0006290)2.59829755
160sequestering of actin monomers (GO:0042989)2.59741075
161spinal cord association neuron differentiation (GO:0021527)2.59721026
162regulation of mitochondrial fission (GO:0090140)2.59305059
163regulation of oligodendrocyte differentiation (GO:0048713)2.59294220
164ubiquinone biosynthetic process (GO:0006744)2.58862753
165cilium morphogenesis (GO:0060271)2.58197364
166protein-cofactor linkage (GO:0018065)2.56167274
167reflex (GO:0060004)2.54396049
168spinal cord motor neuron differentiation (GO:0021522)2.54218480
169reciprocal meiotic recombination (GO:0007131)2.53721162
170reciprocal DNA recombination (GO:0035825)2.53721162
171cytidine deamination (GO:0009972)2.53341708
172cytidine metabolic process (GO:0046087)2.53341708
173cytidine catabolic process (GO:0006216)2.53341708
174nephron tubule morphogenesis (GO:0072078)2.52479654
175nephron epithelium morphogenesis (GO:0072088)2.52479654
176establishment of protein localization to Golgi (GO:0072600)2.52192224
177primary amino compound metabolic process (GO:1901160)2.51071494
178preassembly of GPI anchor in ER membrane (GO:0016254)2.50989421
179mannosylation (GO:0097502)2.50724278
180regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49780599
181axoneme assembly (GO:0035082)2.49670474
182kidney morphogenesis (GO:0060993)2.49510492
183protein K11-linked deubiquitination (GO:0035871)2.49232501
184intraciliary transport (GO:0042073)2.49034126
185membrane depolarization during action potential (GO:0086010)2.48086111
186photoreceptor cell maintenance (GO:0045494)2.47172834
187negative regulation of mast cell activation (GO:0033004)2.46852898
188negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45947809
189photoreceptor cell development (GO:0042461)2.45420036
190thalamus development (GO:0021794)2.45358092
191regulation of cilium movement (GO:0003352)2.44565275
192positive regulation of synapse assembly (GO:0051965)2.42274611
193cilium organization (GO:0044782)2.42223807
194serotonin metabolic process (GO:0042428)2.42202715
195DNA double-strand break processing (GO:0000729)2.41936023
196central nervous system projection neuron axonogenesis (GO:0021952)2.40211505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.81866669
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.13090748
3ZNF274_21170338_ChIP-Seq_K562_Hela3.87785373
4GBX2_23144817_ChIP-Seq_PC3_Human3.84555796
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.60945612
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.92935409
7TAF15_26573619_Chip-Seq_HEK293_Human2.82009842
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.72632478
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.63786509
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50740479
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42618522
12VDR_22108803_ChIP-Seq_LS180_Human2.39438884
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36110416
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30862487
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18702553
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09034488
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98446360
18EZH2_22144423_ChIP-Seq_EOC_Human1.90494924
19EWS_26573619_Chip-Seq_HEK293_Human1.87210097
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87039393
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82885427
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76914862
23P300_19829295_ChIP-Seq_ESCs_Human1.73901177
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71137610
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69441278
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.67918492
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.63647527
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62397330
29AR_21572438_ChIP-Seq_LNCaP_Human1.62362335
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60646705
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60245006
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60177654
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.59986416
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59789461
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58926720
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58561932
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55915703
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54807784
39TP53_22573176_ChIP-Seq_HFKS_Human1.54409574
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53454310
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.53311961
42HTT_18923047_ChIP-ChIP_STHdh_Human1.53074095
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52472845
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.52142516
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51945476
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.51794037
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51365460
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51136802
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49024623
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.48219356
51IGF1R_20145208_ChIP-Seq_DFB_Human1.47188825
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.46054513
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.45205084
54SMAD4_21799915_ChIP-Seq_A2780_Human1.44406049
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43913274
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42855038
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42256701
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40889990
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40694079
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40381636
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39747570
62DROSHA_22980978_ChIP-Seq_HELA_Human1.37869792
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36453007
64MYC_18940864_ChIP-ChIP_HL60_Human1.35568974
65P53_22387025_ChIP-Seq_ESCs_Mouse1.35137806
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.35046446
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34773470
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.34624519
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.34550405
70REST_21632747_ChIP-Seq_MESCs_Mouse1.33608794
71P300_18555785_Chip-Seq_ESCs_Mouse1.33518011
72BCAT_22108803_ChIP-Seq_LS180_Human1.32741437
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32712436
74IRF1_19129219_ChIP-ChIP_H3396_Human1.32543379
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32139014
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31734264
77STAT3_23295773_ChIP-Seq_U87_Human1.29835237
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28328556
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27628194
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27628194
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27410907
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.27080273
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.27009076
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26428656
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24683445
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.24192922
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22421691
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22337569
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.21789643
90CBP_20019798_ChIP-Seq_JUKART_Human1.20750720
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20750720
92RNF2_27304074_Chip-Seq_NSC_Mouse1.20494780
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.20399061
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19187617
95ER_23166858_ChIP-Seq_MCF-7_Human1.19110087
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19096020
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.19037454
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18790853
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18126190
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.16886530
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16726514
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12514842
103PU1_27457419_Chip-Seq_LIVER_Mouse1.12111128
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11888970
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.11847094
106SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11716271
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11392574
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.11277876
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11028280
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11002155
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.10763991
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10457784
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.10273535
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09808524
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09370145
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.09280483
117FUS_26573619_Chip-Seq_HEK293_Human1.09216659
118RUNX2_22187159_ChIP-Seq_PCA_Human1.08924797
119ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08494050
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07731588
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07167890
122TCF4_23295773_ChIP-Seq_U87_Human1.06911036
123GATA3_21878914_ChIP-Seq_MCF-7_Human1.06492877
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05309421
125ZFX_18555785_Chip-Seq_ESCs_Mouse1.05238742
126* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04946280
127* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04946280
128AR_25329375_ChIP-Seq_VCAP_Human1.04917152
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.04538140
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02980356
131RNF2_27304074_Chip-Seq_ESCs_Mouse1.01751454
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00816353
133SOX2_16153702_ChIP-ChIP_HESCs_Human0.98805345
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.98251981
135NCOR_22424771_ChIP-Seq_293T_Human0.96936581
136TCF4_22108803_ChIP-Seq_LS180_Human0.95933821
137VDR_23849224_ChIP-Seq_CD4+_Human0.95275932
138* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94436994
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92411967
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.91571749
141SOX2_19829295_ChIP-Seq_ESCs_Human0.90671859
142NANOG_19829295_ChIP-Seq_ESCs_Human0.90671859
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90564930
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90461523
145FOXA1_25329375_ChIP-Seq_VCAP_Human0.90461523
146ERA_21632823_ChIP-Seq_H3396_Human0.87711762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.95380083
2MP0005360_urolithiasis6.26496654
3MP0005085_abnormal_gallbladder_physiolo5.44094606
4MP0005365_abnormal_bile_salt4.74845073
5MP0008875_abnormal_xenobiotic_pharmacok4.09918120
6MP0003122_maternal_imprinting3.19072439
7MP0003252_abnormal_bile_duct3.15656477
8MP0010329_abnormal_lipoprotein_level2.77693340
9MP0009697_abnormal_copulation2.66773739
10MP0008877_abnormal_DNA_methylation2.30347941
11MP0003121_genomic_imprinting2.30169551
12MP0002653_abnormal_ependyma_morphology2.27377155
13MP0002736_abnormal_nociception_after2.21038098
14MP0003806_abnormal_nucleotide_metabolis2.16339875
15MP0001666_abnormal_nutrient_absorption2.09115791
16MP0002876_abnormal_thyroid_physiology2.06939537
17MP0003195_calcinosis2.06342920
18MP0000569_abnormal_digit_pigmentation1.96888947
19MP0005083_abnormal_biliary_tract1.90051712
20MP0005646_abnormal_pituitary_gland1.82908872
21MP0005332_abnormal_amino_acid1.82256235
22MP0003880_abnormal_central_pattern1.78156709
23MP0004133_heterotaxia1.76831594
24MP0003868_abnormal_feces_composition1.76423980
25MP0001764_abnormal_homeostasis1.72078476
26MP0000631_abnormal_neuroendocrine_gland1.67469966
27MP0000566_synostosis1.67446044
28MP0008995_early_reproductive_senescence1.66350967
29MP0004381_abnormal_hair_follicle1.63054617
30MP0004019_abnormal_vitamin_homeostasis1.62976749
31MP0005253_abnormal_eye_physiology1.57021260
32MP0001984_abnormal_olfaction1.54549766
33MP0004885_abnormal_endolymph1.54061971
34MP0002118_abnormal_lipid_homeostasis1.48979677
35MP0006072_abnormal_retinal_apoptosis1.47465175
36MP0001485_abnormal_pinna_reflex1.46289070
37MP0002733_abnormal_thermal_nociception1.42555119
38MP0001970_abnormal_pain_threshold1.39962346
39MP0006276_abnormal_autonomic_nervous1.39892084
40MP0001486_abnormal_startle_reflex1.35493304
41MP0000609_abnormal_liver_physiology1.34357162
42MP0004142_abnormal_muscle_tone1.32370889
43MP0002837_dystrophic_cardiac_calcinosis1.32025975
44MP0009745_abnormal_behavioral_response1.31855875
45MP0008872_abnormal_physiological_respon1.29030667
46MP0008789_abnormal_olfactory_epithelium1.28905616
47MP0002751_abnormal_autonomic_nervous1.28579859
48MP0009840_abnormal_foam_cell1.28266641
49MP0009046_muscle_twitch1.27733527
50MP0002822_catalepsy1.26168586
51MP0005647_abnormal_sex_gland1.25756465
52MP0002234_abnormal_pharynx_morphology1.22128872
53MP0002163_abnormal_gland_morphology1.21816357
54MP0000778_abnormal_nervous_system1.19028361
55MP0002752_abnormal_somatic_nervous1.18913093
56MP0005551_abnormal_eye_electrophysiolog1.18896107
57MP0005408_hypopigmentation1.18633949
58MP0002184_abnormal_innervation1.18301871
59MP0003011_delayed_dark_adaptation1.17433081
60MP0002272_abnormal_nervous_system1.17421824
61MP0002882_abnormal_neuron_morphology1.16581546
62MP0004147_increased_porphyrin_level1.16547758
63MP0004043_abnormal_pH_regulation1.16468985
64MP0000049_abnormal_middle_ear1.15876875
65MP0003646_muscle_fatigue1.14861866
66MP0005075_abnormal_melanosome_morpholog1.14388695
67MP0006292_abnormal_olfactory_placode1.14311485
68MP0002138_abnormal_hepatobiliary_system1.12875737
69MP0002064_seizures1.12359009
70MP0005451_abnormal_body_composition1.11704376
71MP0003283_abnormal_digestive_organ1.11696704
72MP0004270_analgesia1.11518244
73MP0001188_hyperpigmentation1.11327491
74MP0005377_hearing/vestibular/ear_phenot1.10725755
75MP0003878_abnormal_ear_physiology1.10725755
76MP0002572_abnormal_emotion/affect_behav1.10410088
77MP0004145_abnormal_muscle_electrophysio1.09386337
78MP0002938_white_spotting1.08623087
79MP0004859_abnormal_synaptic_plasticity1.07750809
80MP0003191_abnormal_cellular_cholesterol1.05019210
81MP0003635_abnormal_synaptic_transmissio1.04642910
82MP0001986_abnormal_taste_sensitivity1.03485699
83MP0005195_abnormal_posterior_eye1.02248017
84MP0005389_reproductive_system_phenotype1.02192417
85MP0003690_abnormal_glial_cell1.02015939
86MP0004811_abnormal_neuron_physiology1.01950825
87MP0001529_abnormal_vocalization1.00693583
88MP0002063_abnormal_learning/memory/cond1.00009498
89MP0005409_darkened_coat_color0.99193380
90MP0001919_abnormal_reproductive_system0.98424961
91MP0005584_abnormal_enzyme/coenzyme_acti0.98031223
92MP0009765_abnormal_xenobiotic_induced0.95812956
93MP0002160_abnormal_reproductive_system0.95807490
94MP0005084_abnormal_gallbladder_morpholo0.95108828
95MP0000427_abnormal_hair_cycle0.94731609
96MP0002928_abnormal_bile_duct0.94076068
97MP0002152_abnormal_brain_morphology0.93683170
98MP0004742_abnormal_vestibular_system0.92650697
99MP0002095_abnormal_skin_pigmentation0.91901895
100MP0001440_abnormal_grooming_behavior0.89451828
101MP0002557_abnormal_social/conspecific_i0.89361164
102MP0002067_abnormal_sensory_capabilities0.88958308
103MP0002638_abnormal_pupillary_reflex0.88685920
104MP0000372_irregular_coat_pigmentation0.88007237
105MP0009764_decreased_sensitivity_to0.87335409
106MP0003119_abnormal_digestive_system0.86201196
107MP0002102_abnormal_ear_morphology0.85354979
108MP0001661_extended_life_span0.85039004
109MP0005645_abnormal_hypothalamus_physiol0.84433769
110MP0003137_abnormal_impulse_conducting0.84389533
111MP0005319_abnormal_enzyme/_coenzyme0.83753370
112MP0004924_abnormal_behavior0.82683427
113MP0005386_behavior/neurological_phenoty0.82683427
114MP0003698_abnormal_male_reproductive0.79966491
115MP0002909_abnormal_adrenal_gland0.79948436
116MP0002735_abnormal_chemical_nociception0.79513753
117MP0001968_abnormal_touch/_nociception0.78831074
118MP0003656_abnormal_erythrocyte_physiolo0.78300363
119MP0001502_abnormal_circadian_rhythm0.76906195
120MP0005423_abnormal_somatic_nervous0.75504579
121MP0005171_absent_coat_pigmentation0.74266770
122MP0003787_abnormal_imprinting0.74134843
123MP0003718_maternal_effect0.70712414
124MP0005379_endocrine/exocrine_gland_phen0.70331670
125MP0005535_abnormal_body_temperature0.70277304
126MP0003183_abnormal_peptide_metabolism0.69699131
127MP0009780_abnormal_chondrocyte_physiolo0.69552200
128MP0002277_abnormal_respiratory_mucosa0.69166673
129MP0001905_abnormal_dopamine_level0.67603021
130MP0000920_abnormal_myelination0.67413530
131MP0001177_atelectasis0.67233568
132MP0002734_abnormal_mechanical_nocicepti0.67149106
133MP0005448_abnormal_energy_balance0.66569348
134MP0001501_abnormal_sleep_pattern0.66351672
135MP0005394_taste/olfaction_phenotype0.66228430
136MP0005499_abnormal_olfactory_system0.66228430
137MP0002229_neurodegeneration0.65999050
138MP0001963_abnormal_hearing_physiology0.64407940
139MP0005636_abnormal_mineral_homeostasis0.64380042
140MP0000026_abnormal_inner_ear0.61226438
141MP0000639_abnormal_adrenal_gland0.60910835
142MP0009642_abnormal_blood_homeostasis0.60776082
143MP0002069_abnormal_eating/drinking_beha0.60321325
144MP0001324_abnormal_eye_pigmentation0.60048245
145MP0003136_yellow_coat_color0.58751321
146MP0000955_abnormal_spinal_cord0.58737328

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.16700533
2Intrahepatic cholestasis (HP:0001406)6.15106659
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.52791663
4Hypobetalipoproteinemia (HP:0003563)5.28207345
5Conjugated hyperbilirubinemia (HP:0002908)5.23906685
6Type II lissencephaly (HP:0007260)5.12859859
7Deep venous thrombosis (HP:0002625)5.03596523
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.84241929
9Joint hemorrhage (HP:0005261)4.38567621
10Complement deficiency (HP:0004431)4.21829509
11Hyperlipoproteinemia (HP:0010980)4.18583890
12Xanthomatosis (HP:0000991)4.17672822
13Pancreatic cysts (HP:0001737)4.11167628
14Epidermoid cyst (HP:0200040)4.03316282
15Cerebellar dysplasia (HP:0007033)3.95933772
16Retinal dysplasia (HP:0007973)3.89602132
17Lissencephaly (HP:0001339)3.70286903
18True hermaphroditism (HP:0010459)3.64315657
19Molar tooth sign on MRI (HP:0002419)3.62348266
20Abnormality of midbrain morphology (HP:0002418)3.62348266
21Pancreatic fibrosis (HP:0100732)3.58858027
22Fat malabsorption (HP:0002630)3.54019295
23Abnormality of methionine metabolism (HP:0010901)3.50298225
24Hypolipoproteinemia (HP:0010981)3.43070448
25Hyperglycinemia (HP:0002154)3.38012032
26Nephronophthisis (HP:0000090)3.33489285
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29141056
28Fair hair (HP:0002286)3.26945750
29Abnormality of pyrimidine metabolism (HP:0004353)3.25687834
30Medial flaring of the eyebrow (HP:0010747)3.23634516
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.17295830
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.16309030
33Hyperventilation (HP:0002883)3.07545653
34Pendular nystagmus (HP:0012043)3.07307125
35Abnormality of the common coagulation pathway (HP:0010990)3.06546743
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.02380116
37Hyperglycinuria (HP:0003108)2.94085235
38Hypochromic microcytic anemia (HP:0004840)2.89947355
39Gait imbalance (HP:0002141)2.89604430
40Hypoplasia of the pons (HP:0012110)2.88679287
41Abnormality of glycine metabolism (HP:0010895)2.88604664
42Abnormality of serine family amino acid metabolism (HP:0010894)2.88604664
43Febrile seizures (HP:0002373)2.88252780
44Pachygyria (HP:0001302)2.87169160
45Abnormality of the renal medulla (HP:0100957)2.86896405
46Hyperbilirubinemia (HP:0002904)2.82808959
47Abolished electroretinogram (ERG) (HP:0000550)2.81142695
48Acanthocytosis (HP:0001927)2.80380994
49Abnormality of complement system (HP:0005339)2.75446663
50Abnormality of the renal cortex (HP:0011035)2.74617350
51Abnormality of the pons (HP:0007361)2.71569601
52Hyperammonemia (HP:0001987)2.68733096
53Congenital stationary night blindness (HP:0007642)2.67624992
54Congenital primary aphakia (HP:0007707)2.65381581
55Abnormal biliary tract physiology (HP:0012439)2.64752541
56Bile duct proliferation (HP:0001408)2.64752541
57Hypercholesterolemia (HP:0003124)2.60890113
58Ketosis (HP:0001946)2.56717793
59Focal motor seizures (HP:0011153)2.55198640
60Cystic liver disease (HP:0006706)2.54746674
61Abnormality of the intrinsic pathway (HP:0010989)2.53840879
62Nephrogenic diabetes insipidus (HP:0009806)2.53446947
63Hypoalphalipoproteinemia (HP:0003233)2.51864031
64Hypoplasia of the brainstem (HP:0002365)2.50811353
65Aplasia/Hypoplasia of the brainstem (HP:0007362)2.50811353
66Abnormality of serum amino acid levels (HP:0003112)2.49300081
67Renal cortical cysts (HP:0000803)2.46119047
68Scanning speech (HP:0002168)2.44959839
69Polyphagia (HP:0002591)2.44827798
70Inability to walk (HP:0002540)2.39808018
71Steatorrhea (HP:0002570)2.39036723
72Delayed CNS myelination (HP:0002188)2.38500138
73Blue irides (HP:0000635)2.37455268
74Severe muscular hypotonia (HP:0006829)2.35619076
75Generalized hypopigmentation of hair (HP:0011358)2.34514857
76Anencephaly (HP:0002323)2.31196843
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30537623
78Chronic hepatic failure (HP:0100626)2.26535740
79Genetic anticipation (HP:0003743)2.25093229
80Chorioretinal atrophy (HP:0000533)2.24885539
81Sclerocornea (HP:0000647)2.24111977
82Spontaneous abortion (HP:0005268)2.23387457
83Enlarged kidneys (HP:0000105)2.22765459
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22486469
85Abnormality of alanine metabolism (HP:0010916)2.22486469
86Hyperalaninemia (HP:0003348)2.22486469
87Abnormality of the labia minora (HP:0012880)2.20292475
88Metabolic acidosis (HP:0001942)2.20165624
89Decreased central vision (HP:0007663)2.19340729
90Attenuation of retinal blood vessels (HP:0007843)2.18753663
91Vaginal atresia (HP:0000148)2.15229622
92Postaxial foot polydactyly (HP:0001830)2.14728571
93Genital tract atresia (HP:0001827)2.13809073
94Status epilepticus (HP:0002133)2.12759835
95Poikilocytosis (HP:0004447)2.11227394
96Keratoconus (HP:0000563)2.10146989
97Increased corneal curvature (HP:0100692)2.10146989
98Progressive cerebellar ataxia (HP:0002073)2.08939080
99Poor coordination (HP:0002370)2.08478064
100Neonatal hypoglycemia (HP:0001998)2.07705865
101Agitation (HP:0000713)2.06384850
102Optic nerve hypoplasia (HP:0000609)2.05634085
103Patellar aplasia (HP:0006443)2.04608386
104Hypophosphatemic rickets (HP:0004912)2.03999129
105Congenital hepatic fibrosis (HP:0002612)2.02931570
106Abnormal rod and cone electroretinograms (HP:0008323)2.02650579
107Dry hair (HP:0011359)2.00896978
108Abnormality of the corticospinal tract (HP:0002492)2.00738936
109Hemiparesis (HP:0001269)1.98555518
110Neoplasm of the adrenal cortex (HP:0100641)1.98323267
111Postaxial hand polydactyly (HP:0001162)1.98322776
112Mitochondrial inheritance (HP:0001427)1.98313897
113Colon cancer (HP:0003003)1.97841626
114Vascular calcification (HP:0004934)1.97543211
115Acute necrotizing encephalopathy (HP:0006965)1.97277088
116Abnormal hair whorl (HP:0010721)1.96841869
117Epileptic encephalopathy (HP:0200134)1.96187770
118Abnormality of nucleobase metabolism (HP:0010932)1.95730847
119Dandy-Walker malformation (HP:0001305)1.93997167
120Tubular atrophy (HP:0000092)1.93960997
121Glomerulonephritis (HP:0000099)1.93576031
122Abnormality of DNA repair (HP:0003254)1.93523331
123Specific learning disability (HP:0001328)1.93055913
124Oligodactyly (hands) (HP:0001180)1.92464630
125Menorrhagia (HP:0000132)1.91278969
126Hypoglycemic seizures (HP:0002173)1.91072687
127Osteomalacia (HP:0002749)1.90686280
128Aplasia/Hypoplasia of the patella (HP:0006498)1.90639432
129Limb dystonia (HP:0002451)1.90118273
130Broad-based gait (HP:0002136)1.89892979
131Gingival bleeding (HP:0000225)1.89301651
132Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88941125
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88727406
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.88671194
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86042111
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.86042111
137Hypothermia (HP:0002045)1.85253407
138Confusion (HP:0001289)1.82910533
139Focal seizures (HP:0007359)1.81887119
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.81500612
141Hepatocellular carcinoma (HP:0001402)1.80755129
142Concave nail (HP:0001598)1.79921911
143Thyroid-stimulating hormone excess (HP:0002925)1.79252752
144Anterior segment dysgenesis (HP:0007700)1.79246958
145Polydipsia (HP:0001959)1.78688879
146Abnormal drinking behavior (HP:0030082)1.78688879
147Intestinal atresia (HP:0011100)1.78605117
148Male pseudohermaphroditism (HP:0000037)1.78294097
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78291813
150Cerebral palsy (HP:0100021)1.77897274
151Skin nodule (HP:0200036)1.77852136
152Polymicrogyria (HP:0002126)1.77772691
153Acute encephalopathy (HP:0006846)1.76827113
154Protruding tongue (HP:0010808)1.75892861
155Absent speech (HP:0001344)1.75629868
156Occipital encephalocele (HP:0002085)1.74540869
157Progressive inability to walk (HP:0002505)1.74383142
158Dynein arm defect of respiratory motile cilia (HP:0012255)1.74260931
159Absent/shortened dynein arms (HP:0200106)1.74260931
160Methylmalonic acidemia (HP:0002912)1.72781878
161Mitral stenosis (HP:0001718)1.72755110
1623-Methylglutaconic aciduria (HP:0003535)1.71790626
163Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71638160
164Opisthotonus (HP:0002179)1.71570137
165Large for gestational age (HP:0001520)1.71553759
166Increased CSF lactate (HP:0002490)1.70955343
167Failure to thrive in infancy (HP:0001531)1.70711025
168Elevated hepatic transaminases (HP:0002910)1.70516913
169Abnormality of the axillary hair (HP:0100134)1.70318384
170Abnormality of secondary sexual hair (HP:0009888)1.70318384
171Lethargy (HP:0001254)1.70146287
172Hepatocellular necrosis (HP:0001404)1.69777022
173Tubulointerstitial nephritis (HP:0001970)1.69569961
174Rib fusion (HP:0000902)1.69001778
175Abnormal mitochondria in muscle tissue (HP:0008316)1.68750428
176Symptomatic seizures (HP:0011145)1.67159100
177Abnormality of fatty-acid metabolism (HP:0004359)1.63843126
178Brushfield spots (HP:0001088)1.63481813
179Gaze-evoked nystagmus (HP:0000640)1.62693235
180Drooling (HP:0002307)1.62552229
181Excessive salivation (HP:0003781)1.62552229
182Systemic lupus erythematosus (HP:0002725)1.61643905
183Progressive external ophthalmoplegia (HP:0000590)1.58806926
184Pancreatitis (HP:0001733)1.58422686
185Impaired vibratory sensation (HP:0002495)1.58282430
186Morphological abnormality of the pyramidal tract (HP:0002062)1.56522272
187Alkalosis (HP:0001948)1.56518365
188Cerebral edema (HP:0002181)1.56235019
189Abnormality of vitamin metabolism (HP:0100508)1.56020904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.54656752
2INSRR3.27816812
3MAP4K23.08229914
4SIK32.73020942
5TNIK2.60643836
6PRPF4B2.41301081
7MAP2K72.30891847
8WNK42.26100598
9AKT32.24261361
10MARK12.14922912
11BCR2.11672143
12NEK62.08363823
13TLK12.04615283
14FGFR21.90132281
15SGK21.85263366
16STK161.80813514
17FGFR41.77877433
18TRIM281.76478415
19EPHA41.66107444
20TXK1.63918257
21SGK4941.55381370
22SGK2231.55381370
23YES11.53181407
24IRAK21.51453206
25ERBB41.47883004
26NTRK31.47687172
27MAP3K141.45338377
28GRK11.43060889
29SRPK11.41536118
30IRAK31.40604740
31OXSR11.39149748
32ZAK1.36973517
33NUAK11.33462037
34MKNK21.33283709
35PKN11.29695191
36SIK21.29608611
37ADRBK21.26862169
38MAPK131.22881603
39KSR11.20142360
40TAOK31.17744174
41IRAK11.13804948
42MAP3K41.13417822
43MAP2K41.13320726
44SGK31.13095276
45BRD41.09792878
46PAK31.07355071
47CAMKK21.06004355
48MAPK71.05703808
49CDK191.01827613
50CDK30.99552152
51VRK10.98164371
52BMPR20.93955600
53PRKCG0.93302666
54SIK10.93048437
55NTRK20.92732736
56ACVR1B0.92174452
57RPS6KA50.91784398
58DYRK30.90454182
59NME10.90096804
60DYRK20.89380560
61EIF2AK10.87694637
62FES0.87437304
63IRAK40.85604596
64EPHA30.83828662
65TNK20.81022878
66EIF2AK20.79631115
67PRKCE0.77693374
68CSNK1A1L0.77116602
69CAMK1G0.75624744
70PINK10.75445954
71ADRBK10.74474617
72DYRK1B0.74194267
73MAP2K60.74121538
74CAMK2B0.73081452
75DAPK20.72722036
76CSNK1G10.71766170
77CCNB10.71232908
78PHKG20.70871246
79PHKG10.70871246
80MAP3K120.68824450
81MAP4K10.68431191
82STK110.66329403
83TIE10.65840502
84ERBB20.65165360
85PRKAA20.65099503
86UHMK10.63887616
87CSNK1G30.63251440
88PRKCQ0.62172410
89BCKDK0.61757704
90RPS6KB10.60863087
91CAMK2G0.60792401
92MAPKAPK50.59861068
93PNCK0.59501432
94PRKCZ0.59131904
95PIK3CA0.58992113
96STK390.57884546
97SGK10.56673170
98CSNK1G20.56449014
99WNK30.56056324
100ERBB30.55657897
101PTK2B0.55616306
102CAMK40.55464772
103FRK0.55035368
104FGFR30.54922004
105CAMK1D0.54386668
106BMPR1B0.51801267
107DYRK1A0.51362464
108CAMK2A0.51085840
109CAMK10.50374047
110TESK20.50319813
111PLK20.50145513
112IKBKE0.46952896
113CSNK1D0.45729317
114ATR0.45164039
115MUSK0.44549116
116PIK3CG0.44102821
117MARK30.43556650
118MAPK150.42397590
119PAK60.42008126
120FER0.41322022
121MAP3K110.40786519
122MINK10.40693400
123MKNK10.40536184
124CDK50.40148312
125CSNK1A10.38837719
126PRKACA0.38709747
127TEC0.38641449
128CAMKK10.38445757
129WNK10.38098212
130PRKACG0.37794546
131MARK20.37760631
132MAP3K130.37605124
133TYRO30.36900009
134MAPK120.35805604
135CAMK2D0.35497910
136PRKG10.35361777
137EPHB10.35064566
138MAPK40.34325736
139RPS6KA40.33310798
140PRKAA10.33301910
141NLK0.32941096
142CHUK0.32902254
143PRKCA0.32221539
144PIM10.32106410

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40385429
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.97402352
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76289771
4Nitrogen metabolism_Homo sapiens_hsa009102.75849587
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70576906
6Arginine biosynthesis_Homo sapiens_hsa002202.66581547
7Complement and coagulation cascades_Homo sapiens_hsa046102.62292442
8Tryptophan metabolism_Homo sapiens_hsa003802.55102733
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.50834211
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.46730463
11Butanoate metabolism_Homo sapiens_hsa006502.34104407
12Oxidative phosphorylation_Homo sapiens_hsa001902.33775636
13Parkinsons disease_Homo sapiens_hsa050122.19155782
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.16930453
15Peroxisome_Homo sapiens_hsa041462.10344157
16Fanconi anemia pathway_Homo sapiens_hsa034602.06875213
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03601243
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03150244
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02021778
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.95332282
21Histidine metabolism_Homo sapiens_hsa003401.95183351
22Retinol metabolism_Homo sapiens_hsa008301.95033597
23Fatty acid elongation_Homo sapiens_hsa000621.91213238
24RNA polymerase_Homo sapiens_hsa030201.89997271
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89272766
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89047303
27Fatty acid degradation_Homo sapiens_hsa000711.86088979
28beta-Alanine metabolism_Homo sapiens_hsa004101.77992062
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73881050
30Primary immunodeficiency_Homo sapiens_hsa053401.73016754
31Basal transcription factors_Homo sapiens_hsa030221.72758103
32Steroid biosynthesis_Homo sapiens_hsa001001.72576236
33Chemical carcinogenesis_Homo sapiens_hsa052041.70889769
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70679659
35Homologous recombination_Homo sapiens_hsa034401.64311477
36ABC transporters_Homo sapiens_hsa020101.62137796
37Staphylococcus aureus infection_Homo sapiens_hsa051501.60247316
38Cardiac muscle contraction_Homo sapiens_hsa042601.59451225
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.57784136
40PPAR signaling pathway_Homo sapiens_hsa033201.56095510
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53976285
42Caffeine metabolism_Homo sapiens_hsa002321.53597605
43Tyrosine metabolism_Homo sapiens_hsa003501.52675734
44Fatty acid metabolism_Homo sapiens_hsa012121.51433060
45Propanoate metabolism_Homo sapiens_hsa006401.51073823
46Dopaminergic synapse_Homo sapiens_hsa047281.46552532
47Sulfur metabolism_Homo sapiens_hsa009201.45693784
48Huntingtons disease_Homo sapiens_hsa050161.45488306
49Phenylalanine metabolism_Homo sapiens_hsa003601.43828192
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.43470753
51Bile secretion_Homo sapiens_hsa049761.36787089
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35076050
53Alzheimers disease_Homo sapiens_hsa050101.33623479
54Vitamin B6 metabolism_Homo sapiens_hsa007501.33589076
55Vitamin digestion and absorption_Homo sapiens_hsa049771.33379657
56Alcoholism_Homo sapiens_hsa050341.26462231
57Protein export_Homo sapiens_hsa030601.13925657
58Fat digestion and absorption_Homo sapiens_hsa049751.13762923
59Starch and sucrose metabolism_Homo sapiens_hsa005001.12455522
60Cholinergic synapse_Homo sapiens_hsa047251.07212748
61Nicotine addiction_Homo sapiens_hsa050331.06745819
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05844959
63RNA degradation_Homo sapiens_hsa030181.02243496
64Long-term depression_Homo sapiens_hsa047301.00322117
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98953016
66Selenocompound metabolism_Homo sapiens_hsa004500.98903404
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.97431792
68Amphetamine addiction_Homo sapiens_hsa050310.96837642
69Arginine and proline metabolism_Homo sapiens_hsa003300.93043720
70Lysine degradation_Homo sapiens_hsa003100.91941473
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86311470
72Pyruvate metabolism_Homo sapiens_hsa006200.85565359
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79484188
74Hedgehog signaling pathway_Homo sapiens_hsa043400.79245070
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75063170
76Folate biosynthesis_Homo sapiens_hsa007900.74395459
77Collecting duct acid secretion_Homo sapiens_hsa049660.74193725
78Salivary secretion_Homo sapiens_hsa049700.72866356
79Synaptic vesicle cycle_Homo sapiens_hsa047210.72637188
80Calcium signaling pathway_Homo sapiens_hsa040200.72088128
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71301578
82Basal cell carcinoma_Homo sapiens_hsa052170.68337029
83Phototransduction_Homo sapiens_hsa047440.68186133
84cAMP signaling pathway_Homo sapiens_hsa040240.61516768
85Fatty acid biosynthesis_Homo sapiens_hsa000610.61146261
86Oxytocin signaling pathway_Homo sapiens_hsa049210.60180050
87Glycerolipid metabolism_Homo sapiens_hsa005610.60133429
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.58422767
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57557644
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56336382
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56188099
92Systemic lupus erythematosus_Homo sapiens_hsa053220.52323214
93Metabolic pathways_Homo sapiens_hsa011000.52153118
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52034843
95Purine metabolism_Homo sapiens_hsa002300.52011374
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51810276
97Gastric acid secretion_Homo sapiens_hsa049710.50292475
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48759061
99Pyrimidine metabolism_Homo sapiens_hsa002400.47720051
100GABAergic synapse_Homo sapiens_hsa047270.46551477
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45788031
102Taste transduction_Homo sapiens_hsa047420.43482571
103Ras signaling pathway_Homo sapiens_hsa040140.42411893
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.39136347
105Base excision repair_Homo sapiens_hsa034100.39115575
106p53 signaling pathway_Homo sapiens_hsa041150.38933772
107Dorso-ventral axis formation_Homo sapiens_hsa043200.38332572
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38232412
109Ether lipid metabolism_Homo sapiens_hsa005650.37860109
110Morphine addiction_Homo sapiens_hsa050320.36092712
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35796139
112Autoimmune thyroid disease_Homo sapiens_hsa053200.34876422
113Ovarian steroidogenesis_Homo sapiens_hsa049130.34764102
114T cell receptor signaling pathway_Homo sapiens_hsa046600.34135646
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33401979
116Biosynthesis of amino acids_Homo sapiens_hsa012300.33043955
117Glutamatergic synapse_Homo sapiens_hsa047240.32696655
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32512760
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31775068
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30630894
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28657034
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28611726
123Hippo signaling pathway_Homo sapiens_hsa043900.28179481
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28156928
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28111510
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27406580
127Linoleic acid metabolism_Homo sapiens_hsa005910.26007776
128Regulation of autophagy_Homo sapiens_hsa041400.25900705
129One carbon pool by folate_Homo sapiens_hsa006700.24742347
130Sulfur relay system_Homo sapiens_hsa041220.21809742
131Axon guidance_Homo sapiens_hsa043600.21756962
132Carbon metabolism_Homo sapiens_hsa012000.21510703
133Sphingolipid metabolism_Homo sapiens_hsa006000.20550056
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19552461
135Glutathione metabolism_Homo sapiens_hsa004800.18057908
136Serotonergic synapse_Homo sapiens_hsa047260.13106521
137Olfactory transduction_Homo sapiens_hsa047400.12907311
138Prion diseases_Homo sapiens_hsa050200.12905605
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12764696
140Arachidonic acid metabolism_Homo sapiens_hsa005900.10173810
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09201488
142Cocaine addiction_Homo sapiens_hsa050300.05658075
143Insulin secretion_Homo sapiens_hsa049110.05249275
144Mineral absorption_Homo sapiens_hsa049780.04365803
145Intestinal immune network for IgA production_Homo sapiens_hsa046720.02925796
146Circadian entrainment_Homo sapiens_hsa047130.02816859
147Circadian rhythm_Homo sapiens_hsa047100.02622688
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.01198682
149Type II diabetes mellitus_Homo sapiens_hsa049300.00514567

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