SLC35E1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung lobe morphogenesis (GO:0060463)8.19543282
2neural tube formation (GO:0001841)6.59414928
3coronary vasculature morphogenesis (GO:0060977)5.41251603
4limb bud formation (GO:0060174)5.25978663
5regulation of ER to Golgi vesicle-mediated transport (GO:0060628)5.23995591
6negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.06976100
7postsynaptic membrane organization (GO:0001941)4.67614254
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.55763303
9somite development (GO:0061053)4.39920507
10negative regulation of DNA recombination (GO:0045910)4.16402238
11olfactory bulb development (GO:0021772)4.13934451
12COPII vesicle coating (GO:0048208)4.10105104
13inner ear receptor stereocilium organization (GO:0060122)4.04491375
14pyrimidine dimer repair (GO:0006290)3.98969750
15Golgi transport vesicle coating (GO:0048200)3.83826927
16COPI coating of Golgi vesicle (GO:0048205)3.83826927
17protein polyglutamylation (GO:0018095)3.81780030
18pyrimidine nucleobase catabolic process (GO:0006208)3.81251028
19regulation of response to osmotic stress (GO:0047484)3.79773840
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76114258
21intra-Golgi vesicle-mediated transport (GO:0006891)3.74790913
22prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.72174748
23gamma-aminobutyric acid transport (GO:0015812)3.71504986
24growth hormone secretion (GO:0030252)3.68429919
25neuron cell-cell adhesion (GO:0007158)3.67174954
26auditory receptor cell stereocilium organization (GO:0060088)3.63568181
27regulation of pigment cell differentiation (GO:0050932)3.55294467
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54311178
29cranial suture morphogenesis (GO:0060363)3.53149424
30eye photoreceptor cell differentiation (GO:0001754)3.49953656
31photoreceptor cell differentiation (GO:0046530)3.49953656
32cell wall macromolecule catabolic process (GO:0016998)3.49905245
33spermatid nucleus differentiation (GO:0007289)3.49368035
34positive regulation of mitochondrial fission (GO:0090141)3.46459784
35positive regulation of developmental pigmentation (GO:0048087)3.42247190
36microtubule depolymerization (GO:0007019)3.39884147
37peptidyl-arginine omega-N-methylation (GO:0035247)3.37050568
38synaptic vesicle exocytosis (GO:0016079)3.35453669
39protein insertion into membrane (GO:0051205)3.33823863
40microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.33171402
41peptidyl-arginine N-methylation (GO:0035246)3.27282544
42peptidyl-arginine methylation (GO:0018216)3.27282544
43presynaptic membrane assembly (GO:0097105)3.26777900
44L-serine transport (GO:0015825)3.26145926
45seminiferous tubule development (GO:0072520)3.24746842
46regulation of helicase activity (GO:0051095)3.24130798
47retrograde transport, vesicle recycling within Golgi (GO:0000301)3.20002403
48single strand break repair (GO:0000012)3.17307738
49protein targeting to Golgi (GO:0000042)3.13712686
50negative regulation of DNA repair (GO:0045738)3.12743979
51establishment of protein localization to Golgi (GO:0072600)3.12209892
52prostate gland growth (GO:0060736)3.11089072
53glial cell proliferation (GO:0014009)3.10914028
54head development (GO:0060322)3.09450418
55motile cilium assembly (GO:0044458)3.08999403
56telomere maintenance via telomerase (GO:0007004)3.07029409
57cilium or flagellum-dependent cell motility (GO:0001539)3.06963218
58cAMP-mediated signaling (GO:0019933)3.04079019
59neurotransmitter-gated ion channel clustering (GO:0072578)3.02009823
60central nervous system projection neuron axonogenesis (GO:0021952)3.00396099
61myelin assembly (GO:0032288)3.00370913
62axon extension (GO:0048675)2.98903087
63vesicle coating (GO:0006901)2.96985570
64double-strand break repair via nonhomologous end joining (GO:0006303)2.96941340
65non-recombinational repair (GO:0000726)2.96941340
66negative regulation of androgen receptor signaling pathway (GO:0060766)2.96604171
67response to pheromone (GO:0019236)2.91853544
68branching involved in prostate gland morphogenesis (GO:0060442)2.90972422
69nonmotile primary cilium assembly (GO:0035058)2.90947486
70spindle assembly involved in mitosis (GO:0090307)2.90214237
71positive regulation of macroautophagy (GO:0016239)2.90204170
72centriole replication (GO:0007099)2.88508424
73regulation of telomere maintenance (GO:0032204)2.86718177
74protein localization to synapse (GO:0035418)2.85610764
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85305757
76positive regulation of synapse assembly (GO:0051965)2.84318248
77retinal cone cell development (GO:0046549)2.84019867
78negative regulation of protein localization to cell surface (GO:2000009)2.83125923
79regulation of DNA endoreduplication (GO:0032875)2.83125876
80ovulation from ovarian follicle (GO:0001542)2.82985150
81craniofacial suture morphogenesis (GO:0097094)2.82371390
82histone H2B ubiquitination (GO:0033523)2.77327395
83cilium morphogenesis (GO:0060271)2.77285283
84embryonic epithelial tube formation (GO:0001838)2.76946024
85cell wall macromolecule metabolic process (GO:0044036)2.75858134
86histone arginine methylation (GO:0034969)2.73723721
87ER to Golgi vesicle-mediated transport (GO:0006888)2.73314693
88vocalization behavior (GO:0071625)2.72432595
89regulation of androgen receptor signaling pathway (GO:0060765)2.72193082
90regulation of respiratory system process (GO:0044065)2.71491805
91protein targeting to lysosome (GO:0006622)2.71212438
92establishment of protein localization to vacuole (GO:0072666)2.71212438
93protein targeting to vacuole (GO:0006623)2.71212438
94response to misfolded protein (GO:0051788)2.70034115
95cardiac ventricle formation (GO:0003211)2.68517544
96nucleobase catabolic process (GO:0046113)2.68333720
97spinal cord motor neuron differentiation (GO:0021522)2.65640049
98lung vasculature development (GO:0060426)2.65389736
99microtubule polymerization or depolymerization (GO:0031109)2.64068985
100inositol metabolic process (GO:0006020)2.63478088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.50632242
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.46844362
3GBX2_23144817_ChIP-Seq_PC3_Human4.24905170
4ZNF274_21170338_ChIP-Seq_K562_Hela3.63572085
5IGF1R_20145208_ChIP-Seq_DFB_Human3.48112866
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40822656
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25498544
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78114647
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.60768129
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57476323
11ER_23166858_ChIP-Seq_MCF-7_Human2.54141189
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48162475
13EWS_26573619_Chip-Seq_HEK293_Human2.40386052
14TAF15_26573619_Chip-Seq_HEK293_Human2.33799874
15AR_21572438_ChIP-Seq_LNCaP_Human2.32751598
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19090878
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.15940738
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14824668
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01256363
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.99919309
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.97377052
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96940590
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95989375
24FUS_26573619_Chip-Seq_HEK293_Human1.92808446
25AR_25329375_ChIP-Seq_VCAP_Human1.88862281
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86288073
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81439450
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80476773
29P300_19829295_ChIP-Seq_ESCs_Human1.80348876
30IRF1_19129219_ChIP-ChIP_H3396_Human1.79814714
31SMAD4_21799915_ChIP-Seq_A2780_Human1.71833873
32RNF2_27304074_Chip-Seq_NSC_Mouse1.64241124
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61564056
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61559773
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.59411796
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58907716
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.58788612
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58357144
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53265574
40FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48979713
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46453919
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45806598
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38189390
44STAT3_23295773_ChIP-Seq_U87_Human1.37547000
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.35663931
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31487470
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29689236
48TP53_16413492_ChIP-PET_HCT116_Human1.26400541
49TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24731103
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24516857
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22596262
52FLI1_21867929_ChIP-Seq_TH2_Mouse1.21783401
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21017784
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16703524
55CBP_20019798_ChIP-Seq_JUKART_Human1.16658296
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16658296
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.15915589
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14969878
59RUNX2_22187159_ChIP-Seq_PCA_Human1.14915384
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10511164
61ELK1_19687146_ChIP-ChIP_HELA_Human1.10409655
62REST_21632747_ChIP-Seq_MESCs_Mouse1.09446162
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.08295422
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.07728284
65ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07518648
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05174721
67JUN_21703547_ChIP-Seq_K562_Human1.04035159
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03069900
69TCF4_23295773_ChIP-Seq_U87_Human1.02662005
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01706998
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00536800
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00324495
73SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98582993
74KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97920372
75EZH2_27304074_Chip-Seq_ESCs_Mouse0.97559634
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96063480
77JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94987044
78ELK1_22589737_ChIP-Seq_MCF10A_Human0.93419509
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91110676
80NANOG_19829295_ChIP-Seq_ESCs_Human0.90557848
81SOX2_19829295_ChIP-Seq_ESCs_Human0.90557848
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90544312
83JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90059975
84TAL1_26923725_Chip-Seq_HPCs_Mouse0.89828658
85NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88563802
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88563802
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88385767
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87465012
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85851384
90AR_19668381_ChIP-Seq_PC3_Human0.84929084
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84703494
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.83861275
93KDM2B_26808549_Chip-Seq_REH_Human0.83235086
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82659354
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82204868
96AHR_22903824_ChIP-Seq_MCF-7_Human0.81539475
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.81015496
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.80863768
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80559979
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78813940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology6.04235477
2MP0001529_abnormal_vocalization3.76803294
3MP0003787_abnormal_imprinting3.26375299
4MP0010030_abnormal_orbit_morphology3.14011550
5MP0002234_abnormal_pharynx_morphology2.96674514
6MP0001984_abnormal_olfaction2.30427388
7MP0001188_hyperpigmentation2.26596492
8MP0001986_abnormal_taste_sensitivity2.08181791
9MP0003385_abnormal_body_wall1.92182897
10MP0004924_abnormal_behavior1.92123510
11MP0005386_behavior/neurological_phenoty1.92123510
12MP0008058_abnormal_DNA_repair1.86763821
13MP0005253_abnormal_eye_physiology1.86119159
14MP0008995_early_reproductive_senescence1.85165114
15MP0003938_abnormal_ear_development1.82830237
16MP0003121_genomic_imprinting1.80758363
17MP0005187_abnormal_penis_morphology1.79707870
18MP0001286_abnormal_eye_development1.74000221
19MP0002751_abnormal_autonomic_nervous1.69811525
20MP0000750_abnormal_muscle_regeneration1.68397739
21MP0009780_abnormal_chondrocyte_physiolo1.63451521
22MP0002653_abnormal_ependyma_morphology1.60645658
23MP0005248_abnormal_Harderian_gland1.60462881
24MP0008057_abnormal_DNA_replication1.56341965
25MP0005409_darkened_coat_color1.55557095
26MP0009046_muscle_twitch1.54554927
27MP0005551_abnormal_eye_electrophysiolog1.53328898
28MP0003119_abnormal_digestive_system1.50712637
29MP0002697_abnormal_eye_size1.49952345
30MP0001299_abnormal_eye_distance/1.47012223
31MP0003011_delayed_dark_adaptation1.42429494
32MP0003172_abnormal_lysosome_physiology1.42309879
33MP0000778_abnormal_nervous_system1.41612835
34MP0003755_abnormal_palate_morphology1.40145421
35MP0005391_vision/eye_phenotype1.39143863
36MP0002233_abnormal_nose_morphology1.36880792
37MP0003937_abnormal_limbs/digits/tail_de1.32328636
38MP0004133_heterotaxia1.31746703
39MP0004270_analgesia1.31314656
40MP0005645_abnormal_hypothalamus_physiol1.31158883
41MP0005499_abnormal_olfactory_system1.30987341
42MP0005394_taste/olfaction_phenotype1.30987341
43MP0004134_abnormal_chest_morphology1.30719224
44MP0002282_abnormal_trachea_morphology1.30597993
45MP0001346_abnormal_lacrimal_gland1.28746114
46MP0000534_abnormal_ureter_morphology1.28427965
47MP0002332_abnormal_exercise_endurance1.28092013
48MP0003315_abnormal_perineum_morphology1.27412447
49MP0004859_abnormal_synaptic_plasticity1.27209990
50MP0000631_abnormal_neuroendocrine_gland1.27037191
51MP0003935_abnormal_craniofacial_develop1.22115991
52MP0001879_abnormal_lymphatic_vessel1.21854043
53MP0000049_abnormal_middle_ear1.16978329
54MP0005195_abnormal_posterior_eye1.16329301
55MP0002295_abnormal_pulmonary_circulatio1.14439737
56MP0000026_abnormal_inner_ear1.13812091
57MP0003950_abnormal_plasma_membrane1.11824196
58MP0005623_abnormal_meninges_morphology1.11526974
59MP0003861_abnormal_nervous_system1.09201439
60MP0002069_abnormal_eating/drinking_beha1.08998657
61MP0002092_abnormal_eye_morphology1.06265378
62MP0002177_abnormal_outer_ear1.05806899
63MP0000647_abnormal_sebaceous_gland1.05675241
64MP0003718_maternal_effect1.04414871
65MP0001293_anophthalmia1.01552876
66MP0006072_abnormal_retinal_apoptosis1.01314544
67MP0000015_abnormal_ear_pigmentation1.00896461
68MP0000462_abnormal_digestive_system1.00364400
69MP0003115_abnormal_respiratory_system1.00099747
70MP0003122_maternal_imprinting0.99299421
71MP0002909_abnormal_adrenal_gland0.99185480
72MP0001919_abnormal_reproductive_system0.98632300
73MP0009703_decreased_birth_body0.98190902
74MP0002882_abnormal_neuron_morphology0.96657437
75MP0001764_abnormal_homeostasis0.96595292
76MP0006276_abnormal_autonomic_nervous0.95883788
77MP0003942_abnormal_urinary_system0.94647914
78MP0002752_abnormal_somatic_nervous0.94505947
79MP0003635_abnormal_synaptic_transmissio0.93245548
80MP0002098_abnormal_vibrissa_morphology0.90111422
81MP0000383_abnormal_hair_follicle0.89883451
82MP0002557_abnormal_social/conspecific_i0.89454593
83MP0002081_perinatal_lethality0.87505286
84MP0004811_abnormal_neuron_physiology0.86036704
85MP0004197_abnormal_fetal_growth/weight/0.85778886
86MP0004233_abnormal_muscle_weight0.83849369
87MP0002184_abnormal_innervation0.82280527
88MP0008789_abnormal_olfactory_epithelium0.80741991
89MP0001340_abnormal_eyelid_morphology0.80663257
90MP0001486_abnormal_startle_reflex0.79762365
91MP0008961_abnormal_basal_metabolism0.78837735
92MP0002152_abnormal_brain_morphology0.78382414
93MP0002009_preneoplasia0.77638808
94MP0001270_distended_abdomen0.76754870
95MP0003868_abnormal_feces_composition0.76700774
96MP0002735_abnormal_chemical_nociception0.75969636
97MP0008877_abnormal_DNA_methylation0.75889860
98MP0003698_abnormal_male_reproductive0.75513225
99MP0002063_abnormal_learning/memory/cond0.73003290
100MP0004272_abnormal_basement_membrane0.70643548

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.17407422
2Thickened helices (HP:0000391)4.66665569
3Absent speech (HP:0001344)4.04132070
4Large earlobe (HP:0009748)3.50962710
5Frequent falls (HP:0002359)3.19556510
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.18124710
7Absent/shortened dynein arms (HP:0200106)3.18124710
8Drooling (HP:0002307)3.16739086
9Short 1st metacarpal (HP:0010034)3.12657007
10Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.12657007
11Hypoplastic ischia (HP:0003175)3.09416542
12Widely spaced teeth (HP:0000687)3.07541686
13Upper limb muscle weakness (HP:0003484)3.06706309
14Thyroid-stimulating hormone excess (HP:0002925)3.05426141
15Protruding tongue (HP:0010808)3.00300888
16Hypochromic microcytic anemia (HP:0004840)2.93561764
17Open mouth (HP:0000194)2.91731149
18Excessive salivation (HP:0003781)2.86333084
19Absent frontal sinuses (HP:0002688)2.74605056
20Abnormality of the 1st metacarpal (HP:0010009)2.73488751
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.62818248
22Hand muscle atrophy (HP:0009130)2.61430942
23Tented upper lip vermilion (HP:0010804)2.60902342
24Abnormality of the ischium (HP:0003174)2.53866973
25Cone-rod dystrophy (HP:0000548)2.53422962
26Abnormal ciliary motility (HP:0012262)2.46883190
27Tapered finger (HP:0001182)2.42576765
28Bile duct proliferation (HP:0001408)2.42454040
29Abnormal biliary tract physiology (HP:0012439)2.42454040
30Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.41522308
31Decreased lacrimation (HP:0000633)2.36370283
32Submucous cleft hard palate (HP:0000176)2.33518904
33Gait imbalance (HP:0002141)2.32591675
34Microvesicular hepatic steatosis (HP:0001414)2.31990902
35Facial hemangioma (HP:0000329)2.29577979
36Buphthalmos (HP:0000557)2.28693458
37Gastroesophageal reflux (HP:0002020)2.28453654
38Congenital primary aphakia (HP:0007707)2.26560494
39Volvulus (HP:0002580)2.20885149
40Vaginal atresia (HP:0000148)2.20099925
41Abnormality of the labia minora (HP:0012880)2.17932704
42Nephrogenic diabetes insipidus (HP:0009806)2.16958240
43Heterotopia (HP:0002282)2.15932364
44Poor coordination (HP:0002370)2.15474346
45Hypoplastic iliac wings (HP:0002866)2.15241143
46Nephronophthisis (HP:0000090)2.15158912
47Abnormal respiratory motile cilium morphology (HP:0005938)2.15050611
48Abnormal respiratory epithelium morphology (HP:0012253)2.15050611
49Thickened nuchal skin fold (HP:0000474)2.15048643
50Intellectual disability, moderate (HP:0002342)2.14209462
51Genital tract atresia (HP:0001827)2.12965653
52Medial flaring of the eyebrow (HP:0010747)2.11775490
53Mild short stature (HP:0003502)2.11769210
54Long clavicles (HP:0000890)2.11384891
55Complete atrioventricular canal defect (HP:0001674)2.06927649
56Upper limb amyotrophy (HP:0009129)2.06278417
57Distal upper limb amyotrophy (HP:0007149)2.06278417
58Coxa valga (HP:0002673)2.06266884
59Medulloblastoma (HP:0002885)2.05407407
60Shawl scrotum (HP:0000049)2.04270770
61Impaired smooth pursuit (HP:0007772)2.03882722
62Vitreoretinal degeneration (HP:0000655)2.03096670
63Broad alveolar ridges (HP:0000187)2.01432582
64Cupped ear (HP:0000378)1.99849743
65Short 4th metacarpal (HP:0010044)1.97976053
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97976053
67Short clavicles (HP:0000894)1.94405074
68Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.94373121
69Dysdiadochokinesis (HP:0002075)1.94104859
70Gaze-evoked nystagmus (HP:0000640)1.92645230
71Intellectual disability, progressive (HP:0006887)1.92293134
72Exotropia (HP:0000577)1.91785701
73Single transverse palmar crease (HP:0000954)1.90952378
74Short phalanx of the thumb (HP:0009660)1.89448236
75Alacrima (HP:0000522)1.89165293
76Mixed hearing impairment (HP:0000410)1.88725224
7711 pairs of ribs (HP:0000878)1.88606277
78Papillary thyroid carcinoma (HP:0002895)1.88496069
79Abnormality of dentin (HP:0010299)1.88151145
80Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.86803835
81Neoplasm of the oral cavity (HP:0100649)1.84868346
82Menorrhagia (HP:0000132)1.84100574
83Aplasia/Hypoplasia of the lens (HP:0008063)1.84059964
84Microtia (HP:0008551)1.83659389
85Premature skin wrinkling (HP:0100678)1.82423561
86Congenital glaucoma (HP:0001087)1.82307420
87Smooth philtrum (HP:0000319)1.81172541
88Ulnar bowing (HP:0003031)1.81014979
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80053467
90Deep philtrum (HP:0002002)1.76289061
91Broad palm (HP:0001169)1.75673673
92Peripheral hypomyelination (HP:0007182)1.75407715
93Abnormality of the pubic bones (HP:0003172)1.74138094
94Narrow forehead (HP:0000341)1.71652476
95Atrioventricular canal defect (HP:0006695)1.71154906
96Increased mean platelet volume (HP:0011877)1.70386294
97Abnormality of the wing of the ilium (HP:0011867)1.69962612
98Abnormality of the frontal sinuses (HP:0002687)1.68685817
99Coronal craniosynostosis (HP:0004440)1.66693151
100Abnormal respiratory motile cilium physiology (HP:0012261)1.66542160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.09537905
2MAP4K24.11993099
3AKT33.98207067
4MAP3K43.53805017
5MARK13.11550225
6MAP2K72.83794612
7MAP3K62.45913475
8MAPK132.38923148
9DYRK32.38594494
10BCR2.15550600
11SRPK12.02181193
12WNK32.00506851
13NEK21.68862199
14SGK21.57232115
15SGK4941.56123972
16SGK2231.56123972
17FGFR21.55797559
18PNCK1.50879552
19EPHB11.48862900
20EIF2AK11.47547701
21ERBB21.42379288
22STK161.41698878
23CSNK1A1L1.34596314
24RPS6KA41.30661491
25DDR21.29057022
26CDK31.22663645
27PLK21.14939804
28MAP2K41.12401830
29ERBB31.11488989
30PIK3CA1.08987669
31CSNK1G31.06253032
32UHMK11.01550839
33STK38L0.97989913
34FGR0.96736682
35PLK40.94562424
36DYRK1B0.91886592
37CDK90.91701266
38SGK30.91569247
39PAK30.91176325
40CSNK1G10.86179617
41BCKDK0.86001975
42PRKD30.82742691
43MAPK150.82313154
44INSRR0.81697715
45CAMK1G0.81521474
46TESK10.81210220
47NTRK20.80909946
48DYRK1A0.76697276
49PINK10.76084400
50PAK20.73896478
51MINK10.73595271
52FGFR10.72416601
53CSNK1G20.68842563
54NEK60.67781172
55BRD40.63214310
56SIK30.62969136
57CDK80.58370638
58BRAF0.56008740
59PTK2B0.55918375
60PDGFRB0.54498717
61EEF2K0.52752063
62FRK0.52549334
63MET0.52510699
64RET0.52256689
65MAPK90.52094030
66MAPK100.51746472
67PRKAA10.51741951
68TNK20.50426302
69ERBB40.48031278
70NEK90.45895629
71WNK10.45225495
72CHEK10.45017426
73PRKCE0.44649688
74CDK180.43944145
75STK30.43500618
76MTOR0.43272075
77GSK3B0.43012005
78RPS6KB10.41940848
79YES10.41688795
80SGK10.41688619
81PRKACB0.40635621
82TRIM280.39971431
83TAOK20.39370407
84MARK20.39285131
85PAK60.38918513
86CDK20.38874623
87CDK140.38095336
88CSNK1D0.37772219
89CDK150.37769374
90CDK60.36593954
91MAPK140.36199124
92CSNK1A10.36021040
93PKN20.35941360
94MAPK80.35518989
95CAMK2G0.34871095
96CDK50.34013023
97EIF2AK30.33146764
98CAMK2A0.32219449
99CSNK1E0.32170056
100PRPF4B0.31052789

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034505.01993136
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.83117543
3Sulfur relay system_Homo sapiens_hsa041223.27940533
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.07924235
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.93064285
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73238303
7Steroid biosynthesis_Homo sapiens_hsa001002.20286205
8Butanoate metabolism_Homo sapiens_hsa006502.06646391
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97697625
10GABAergic synapse_Homo sapiens_hsa047271.97312928
11mRNA surveillance pathway_Homo sapiens_hsa030151.66134520
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54819353
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53383521
14Protein export_Homo sapiens_hsa030601.50843003
15Nicotine addiction_Homo sapiens_hsa050331.47213944
16Insulin secretion_Homo sapiens_hsa049111.45613198
17Selenocompound metabolism_Homo sapiens_hsa004501.43441434
18TGF-beta signaling pathway_Homo sapiens_hsa043501.36391087
19Colorectal cancer_Homo sapiens_hsa052101.26351646
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19590810
21Dopaminergic synapse_Homo sapiens_hsa047281.19084949
22Vibrio cholerae infection_Homo sapiens_hsa051101.16205789
23Glutamatergic synapse_Homo sapiens_hsa047241.14705860
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11236710
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09543793
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06963071
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04883698
28Propanoate metabolism_Homo sapiens_hsa006401.04664347
29Circadian entrainment_Homo sapiens_hsa047131.03208965
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02209458
31Cholinergic synapse_Homo sapiens_hsa047251.00426781
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00400779
33AMPK signaling pathway_Homo sapiens_hsa041520.99547057
34Amphetamine addiction_Homo sapiens_hsa050310.99246553
35beta-Alanine metabolism_Homo sapiens_hsa004100.97709076
36RNA transport_Homo sapiens_hsa030130.97689474
37Phototransduction_Homo sapiens_hsa047440.95887392
38Taste transduction_Homo sapiens_hsa047420.95816311
39Cocaine addiction_Homo sapiens_hsa050300.93285225
40Fanconi anemia pathway_Homo sapiens_hsa034600.92872169
41Oocyte meiosis_Homo sapiens_hsa041140.86866022
42Morphine addiction_Homo sapiens_hsa050320.84042871
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84006548
44Notch signaling pathway_Homo sapiens_hsa043300.83844257
45Alcoholism_Homo sapiens_hsa050340.83386009
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80346513
47Circadian rhythm_Homo sapiens_hsa047100.80162690
48Choline metabolism in cancer_Homo sapiens_hsa052310.79385813
49ECM-receptor interaction_Homo sapiens_hsa045120.77828526
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77633420
51Axon guidance_Homo sapiens_hsa043600.74301886
52Small cell lung cancer_Homo sapiens_hsa052220.73329933
53Glioma_Homo sapiens_hsa052140.72835963
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72097459
55Endometrial cancer_Homo sapiens_hsa052130.71576352
56Hippo signaling pathway_Homo sapiens_hsa043900.68291174
57Fatty acid biosynthesis_Homo sapiens_hsa000610.67622703
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67006750
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65766208
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65506421
61Serotonergic synapse_Homo sapiens_hsa047260.65014239
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64203269
63Glycerolipid metabolism_Homo sapiens_hsa005610.63872913
64Prostate cancer_Homo sapiens_hsa052150.63497307
65mTOR signaling pathway_Homo sapiens_hsa041500.62612764
66Olfactory transduction_Homo sapiens_hsa047400.60508848
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59887824
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58175235
69Inositol phosphate metabolism_Homo sapiens_hsa005620.58088505
70ErbB signaling pathway_Homo sapiens_hsa040120.56860562
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.55604928
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53283356
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52332813
74Melanoma_Homo sapiens_hsa052180.52053289
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50053991
76ABC transporters_Homo sapiens_hsa020100.49388253
77Dilated cardiomyopathy_Homo sapiens_hsa054140.48835138
78Ovarian steroidogenesis_Homo sapiens_hsa049130.48664734
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45600895
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45284491
81Nitrogen metabolism_Homo sapiens_hsa009100.41929192
82FoxO signaling pathway_Homo sapiens_hsa040680.41830408
83Caffeine metabolism_Homo sapiens_hsa002320.40717879
84MicroRNAs in cancer_Homo sapiens_hsa052060.39656751
85Long-term depression_Homo sapiens_hsa047300.39566142
86Gap junction_Homo sapiens_hsa045400.37468183
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.36330662
88Tight junction_Homo sapiens_hsa045300.35573389
89Pancreatic cancer_Homo sapiens_hsa052120.35518730
90Type II diabetes mellitus_Homo sapiens_hsa049300.35051663
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34971732
92Endocytosis_Homo sapiens_hsa041440.34407126
93Focal adhesion_Homo sapiens_hsa045100.34335158
94Glucagon signaling pathway_Homo sapiens_hsa049220.34257511
95Synaptic vesicle cycle_Homo sapiens_hsa047210.33249658
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32475174
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32302373
98Basal transcription factors_Homo sapiens_hsa030220.31874461
99Pyruvate metabolism_Homo sapiens_hsa006200.31705818
100Lysine degradation_Homo sapiens_hsa003100.31410175

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