SLC35E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)5.13440937
2hemidesmosome assembly (GO:0031581)4.03468682
3regulation of cholesterol homeostasis (GO:2000188)4.02078723
4desmosome organization (GO:0002934)3.98051783
5lysine metabolic process (GO:0006553)3.76499240
6lysine catabolic process (GO:0006554)3.76499240
74-hydroxyproline metabolic process (GO:0019471)3.58950735
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58063967
9dicarboxylic acid biosynthetic process (GO:0043650)3.50413999
10positive regulation of fatty acid beta-oxidation (GO:0032000)3.46568712
11alpha-linolenic acid metabolic process (GO:0036109)3.44068250
12valine metabolic process (GO:0006573)3.40412338
132-oxoglutarate metabolic process (GO:0006103)3.40302768
14macroautophagy (GO:0016236)3.39164368
15regulation of cell proliferation involved in kidney development (GO:1901722)3.39151898
16regulation of fatty acid beta-oxidation (GO:0031998)3.37008910
17intestinal cholesterol absorption (GO:0030299)3.36146231
18cellular ketone body metabolic process (GO:0046950)3.31348022
19cellular response to ATP (GO:0071318)3.30636091
20phospholipid homeostasis (GO:0055091)3.24956342
21peptidyl-glutamic acid carboxylation (GO:0017187)3.23921148
22protein carboxylation (GO:0018214)3.23921148
23regulation of triglyceride catabolic process (GO:0010896)3.18919419
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.18211113
25L-phenylalanine catabolic process (GO:0006559)3.18211113
26negative regulation of fibrinolysis (GO:0051918)3.17554042
27positive regulation of histone deacetylation (GO:0031065)3.15532306
28kynurenine metabolic process (GO:0070189)3.15402223
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.15088032
30L-phenylalanine metabolic process (GO:0006558)3.15088032
31urea cycle (GO:0000050)3.11403062
32urea metabolic process (GO:0019627)3.11403062
33low-density lipoprotein particle clearance (GO:0034383)3.09816266
34negative regulation of TOR signaling (GO:0032007)3.08651976
35endosome to melanosome transport (GO:0035646)3.07850877
36endosome to pigment granule transport (GO:0043485)3.07850877
37intestinal absorption (GO:0050892)3.06202859
38COPI coating of Golgi vesicle (GO:0048205)3.04104007
39Golgi transport vesicle coating (GO:0048200)3.04104007
40behavioral response to nicotine (GO:0035095)3.03427493
41negative regulation of mast cell activation (GO:0033004)3.03185314
42activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.02117468
43negative regulation of sterol transport (GO:0032372)3.01197267
44negative regulation of cholesterol transport (GO:0032375)3.01197267
45fatty acid transmembrane transport (GO:1902001)3.00241994
46protein localization to endosome (GO:0036010)3.00016469
47white fat cell differentiation (GO:0050872)2.99419611
48high-density lipoprotein particle remodeling (GO:0034375)2.98226008
49carnitine shuttle (GO:0006853)2.97076975
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.95225657
51oxaloacetate metabolic process (GO:0006107)2.93422823
52cellular modified amino acid catabolic process (GO:0042219)2.92047558
53positive regulation of nuclease activity (GO:0032075)2.91878939
54regulation of tight junction assembly (GO:2000810)2.91369575
55negative regulation of axon extension involved in axon guidance (GO:0048843)2.90226505
56negative regulation of protein localization to cell surface (GO:2000009)2.89040186
57positive regulation of lipid catabolic process (GO:0050996)2.87101220
58ketone body metabolic process (GO:1902224)2.86883498
59regulation of integrin-mediated signaling pathway (GO:2001044)2.85909913
60regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85347606
61positive regulation of CREB transcription factor activity (GO:0032793)2.85243011
62cysteine metabolic process (GO:0006534)2.85041006
63iron ion import (GO:0097286)2.84658244
64negative regulation of fatty acid transport (GO:2000192)2.83491666
65insulin-like growth factor receptor signaling pathway (GO:0048009)2.81873010
66negative regulation of lipid transport (GO:0032369)2.80626960
67regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79293782
68positive regulation of triglyceride metabolic process (GO:0090208)2.78648329
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78595486
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78595486
71aspartate family amino acid catabolic process (GO:0009068)2.78449650
72glutamate metabolic process (GO:0006536)2.78299175
73complement activation, alternative pathway (GO:0006957)2.76559589
74sulfur amino acid catabolic process (GO:0000098)2.75940824
75homocysteine metabolic process (GO:0050667)2.75239627
76positive regulation of fatty acid oxidation (GO:0046321)2.73575684
77plasma lipoprotein particle clearance (GO:0034381)2.73482135
78negative regulation of cell size (GO:0045792)2.72716696
79reverse cholesterol transport (GO:0043691)2.72275442
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69874209
81regulation of gamma-delta T cell differentiation (GO:0045586)2.69791196
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69459451
83regulation of protein activation cascade (GO:2000257)2.69198153
84nitrogen cycle metabolic process (GO:0071941)2.69176615
85endothelial cell chemotaxis (GO:0035767)2.68908348
86regulation of sequestering of triglyceride (GO:0010889)2.68794560
87aromatic amino acid family catabolic process (GO:0009074)2.68654392
88lymphangiogenesis (GO:0001946)2.68521399
89cytoplasmic mRNA processing body assembly (GO:0033962)2.65503751
90protein-lipid complex assembly (GO:0065005)2.65478637
91regulation of nuclease activity (GO:0032069)2.65096861
92artery development (GO:0060840)2.64560395
93regulation of cholesterol storage (GO:0010885)2.64445387
94regulation of fibrinolysis (GO:0051917)2.63857694
95growth hormone receptor signaling pathway (GO:0060396)2.63740834
96triglyceride homeostasis (GO:0070328)2.62644745
97acylglycerol homeostasis (GO:0055090)2.62644745
98DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.61232334
99positive regulation of triglyceride biosynthetic process (GO:0010867)2.61104295
100phospholipid efflux (GO:0033700)2.60614797
101endoplasmic reticulum unfolded protein response (GO:0030968)2.60208893
102pharyngeal system development (GO:0060037)2.59829055
103maternal placenta development (GO:0001893)2.59654147
104cellular response to exogenous dsRNA (GO:0071360)2.59212321
105tricarboxylic acid metabolic process (GO:0072350)2.58787768
106regulation of fatty acid oxidation (GO:0046320)2.58087315
107regulation of alkaline phosphatase activity (GO:0010692)2.57501879
108plasma membrane repair (GO:0001778)2.56934883
109cell differentiation involved in embryonic placenta development (GO:0060706)2.56882404
110endocardial cushion development (GO:0003197)2.56469078
111glyoxylate metabolic process (GO:0046487)2.56322712
112regulation of axon extension involved in axon guidance (GO:0048841)2.55380568
113amino-acid betaine metabolic process (GO:0006577)2.54913816
114regulation of complement activation (GO:0030449)2.53885354
115negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.52618946
116regulation of memory T cell differentiation (GO:0043380)2.52289544
117positive regulation of defense response to virus by host (GO:0002230)2.51515069
118plasma lipoprotein particle assembly (GO:0034377)2.51297179
119endoderm formation (GO:0001706)2.50661524
120UDP-N-acetylglucosamine metabolic process (GO:0006047)2.50329914
121lipoprotein metabolic process (GO:0042157)2.49910884
122L-alpha-amino acid transmembrane transport (GO:1902475)2.48360390
123positive regulation of glycogen biosynthetic process (GO:0045725)2.48068845
124ER-nucleus signaling pathway (GO:0006984)2.47806216
125inositol phosphate-mediated signaling (GO:0048016)2.47625223
126mesodermal cell differentiation (GO:0048333)2.46533614
127fatty acid homeostasis (GO:0055089)2.46270211
128fatty acid beta-oxidation (GO:0006635)2.46033469
129negative regulation of cell killing (GO:0031342)2.45982798
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45982798
131regulation of fatty acid biosynthetic process (GO:0042304)2.45941325
132regulation of membrane protein ectodomain proteolysis (GO:0051043)2.45664768
133negative regulation of keratinocyte proliferation (GO:0010839)2.44817208
134negative regulation of sodium ion transport (GO:0010766)2.44642027
135cellular response to unfolded protein (GO:0034620)2.43701440
136sterol homeostasis (GO:0055092)2.43594571
137hormone catabolic process (GO:0042447)2.43349059
138cellular glucuronidation (GO:0052695)2.42552461
139response to lipoprotein particle (GO:0055094)2.41526531
140regulation of triglyceride biosynthetic process (GO:0010866)2.41509040
141positive regulation of fatty acid biosynthetic process (GO:0045723)2.41325992
142regulation of gamma-delta T cell activation (GO:0046643)2.41257193
1433-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.41061342
144purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.41061342
145macromolecular complex remodeling (GO:0034367)2.40821655
146negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.40666069
147lung lobe morphogenesis (GO:0060463)2.40448607
148glycerophospholipid catabolic process (GO:0046475)2.40168459
149cornea development in camera-type eye (GO:0061303)2.40127735
150cellular response to lithium ion (GO:0071285)2.39785974
151negative regulation of systemic arterial blood pressure (GO:0003085)2.38446886
152regulation of action potential (GO:0098900)2.38351478
153cell-substrate junction assembly (GO:0007044)2.38269802
154regulation of histone deacetylation (GO:0031063)2.38022314
155cell adhesion mediated by integrin (GO:0033627)2.35899101
156positive regulation of glomerulus development (GO:0090193)2.35476068
157negative regulation of kidney development (GO:0090185)2.32752066
158regulation of water loss via skin (GO:0033561)2.30063881
159protein heterotrimerization (GO:0070208)2.26850457
160negative regulation of Rho protein signal transduction (GO:0035024)2.25162472
161endocrine hormone secretion (GO:0060986)2.24931248
162regulation of establishment of cell polarity (GO:2000114)2.23563590
163interleukin-1-mediated signaling pathway (GO:0070498)2.19647863
164regulation of receptor binding (GO:1900120)2.19234600
165lung secretory cell differentiation (GO:0061140)2.18001665
166regulation of establishment or maintenance of cell polarity (GO:0032878)2.16322130
167regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.16073994
168regulation of glomerulus development (GO:0090192)2.14663969
169striated muscle atrophy (GO:0014891)2.14124660
170cell migration involved in sprouting angiogenesis (GO:0002042)2.13630004
171positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.13054477
172sphingoid metabolic process (GO:0046519)2.12696826
173polarized epithelial cell differentiation (GO:0030859)2.11486763
174phosphatidylinositol acyl-chain remodeling (GO:0036149)2.11198524
175peristalsis (GO:0030432)2.11087113
176establishment of skin barrier (GO:0061436)2.10812432
177lung vasculature development (GO:0060426)2.10761055
178regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.10569518
179intestinal epithelial cell development (GO:0060576)2.07133317
180facial nerve structural organization (GO:0021612)2.07006617
181pericardium development (GO:0060039)2.06641767
182angiogenesis involved in wound healing (GO:0060055)2.06053787
183negative regulation of homotypic cell-cell adhesion (GO:0034111)2.05761078
184ovulation cycle (GO:0042698)2.05040191
185negative regulation of axon guidance (GO:1902668)2.04562831
186snRNA transcription (GO:0009301)2.04514201
187negative regulation of nitric-oxide synthase activity (GO:0051001)2.04440788
188regulation of axon guidance (GO:1902667)2.04050655
189glucocorticoid receptor signaling pathway (GO:0042921)2.03732421
190skin morphogenesis (GO:0043589)2.03155437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.49512677
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.65753348
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.96220225
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.76558576
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.74519809
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.36839441
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.36175876
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96670589
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.67532786
10AHR_22903824_ChIP-Seq_MCF-7_Human2.63974681
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59265081
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.57099930
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.52620050
14CLOCK_20551151_ChIP-Seq_293T_Human2.46929703
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36975443
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.34485704
17* MYC_22102868_ChIP-Seq_BL_Human2.30938559
18ARNT_22903824_ChIP-Seq_MCF-7_Human2.21055249
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05303398
20TCF7_22412390_ChIP-Seq_EML_Mouse2.05116530
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03956592
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98421864
23* KDM2B_26808549_Chip-Seq_DND41_Human1.92229507
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91552345
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90512602
26* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86536342
27* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81755897
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78374308
29* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75536799
30ZNF263_19887448_ChIP-Seq_K562_Human1.75360763
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.74946895
32LXR_22292898_ChIP-Seq_THP-1_Human1.70527553
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.64870437
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.63858647
35VDR_21846776_ChIP-Seq_THP-1_Human1.62496330
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61226448
37RACK7_27058665_Chip-Seq_MCF-7_Human1.59767429
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57924285
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56410053
40TP53_16413492_ChIP-PET_HCT116_Human1.56154120
41CJUN_26792858_Chip-Seq_BT549_Human1.56142884
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54933462
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54251177
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53674993
45MAF_26560356_Chip-Seq_TH1_Human1.52677776
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49139489
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49139489
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44964239
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.43579851
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43241149
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.42786508
52* ATF3_27146783_Chip-Seq_COLON_Human1.42480197
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42386567
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40797181
55GBX2_23144817_ChIP-Seq_PC3_Human1.40475831
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40189889
57* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39134809
58* TBX20_22328084_ChIP-Seq_HEART_Mouse1.39084730
59* TBX20_22080862_ChIP-Seq_HEART_Mouse1.39084730
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38910821
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38787609
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38114717
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37443184
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34963589
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34931167
66* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34379233
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34118392
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33311031
69* UTX_26944678_Chip-Seq_JUKART_Human1.33156067
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32993447
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31805522
72KDM2B_26808549_Chip-Seq_K562_Human1.31589246
73TP53_23651856_ChIP-Seq_MEFs_Mouse1.31101848
74GATA1_22025678_ChIP-Seq_K562_Human1.30782427
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30328109
76* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29972965
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29792052
78ER_23166858_ChIP-Seq_MCF-7_Human1.27883212
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.27661827
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25460827
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25200002
82DROSHA_22980978_ChIP-Seq_HELA_Human1.23900394
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.22649160
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21938562
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21087286
86TP53_22127205_ChIP-Seq_IMR90_Human1.20628608
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20107164
88GATA1_19941826_ChIP-Seq_K562_Human1.19290711
89CREB1_26743006_Chip-Seq_LNCaP_Human1.17575257
90ZNF274_21170338_ChIP-Seq_K562_Hela1.17237761
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.16630983
92RUNX_20019798_ChIP-Seq_JUKART_Human1.16582976
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16390502
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15658902
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14788099
96GATA6_25053715_ChIP-Seq_YYC3_Human1.14186161
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13835213
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13087173
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13077175
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.12973342
101IRF8_22096565_ChIP-ChIP_GC-B_Human1.12732395
102* GATA3_24758297_ChIP-Seq_MCF-7_Human1.10896200
103SPI1_23127762_ChIP-Seq_K562_Human1.10342991
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09735814
105FOXA1_25552417_ChIP-Seq_VCAP_Human1.09475893
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09026555
107* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08610472
108MYB_26560356_Chip-Seq_TH1_Human1.08567691
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.08559381
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07975225
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07352230
112* NCOR1_26117541_ChIP-Seq_K562_Human1.06558666
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06014158
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04630946
115FOXM1_23109430_ChIP-Seq_U2OS_Human1.04265913
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03734986
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.03555060
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03396483
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03356831
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03086060
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02913969
122ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02858659
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02113242
124MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02076110
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01257866
126VDR_24763502_ChIP-Seq_THP-1_Human1.01076226
127* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00968808
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00911864
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00271294
130* GATA4_25053715_ChIP-Seq_YYC3_Human0.99803030
131GATA2_19941826_ChIP-Seq_K562_Human0.99094508
132MYB_26560356_Chip-Seq_TH2_Human0.98401996
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98045559
134IRF8_27001747_Chip-Seq_BMDM_Mouse0.96957672
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.96912835
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96337205
137RNF2_27304074_Chip-Seq_ESCs_Mouse0.95939366
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95678338
139EED_16625203_ChIP-ChIP_MESCs_Mouse0.95412862
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95192916
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.94837963
142EZH2_27294783_Chip-Seq_ESCs_Mouse0.94832171
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93156097
144BRD4_25478319_ChIP-Seq_HGPS_Human0.93129363
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93120108
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92991492
147STAT3_23295773_ChIP-Seq_U87_Human0.92378084
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92071502
149RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92036948
150EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92036948
151TP63_23658742_ChIP-Seq_EP156T_Human0.91863718
152ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91403849
153TP63_22573176_ChIP-Seq_HFKS_Human0.90991315
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90682684
155SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90622552
156JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90419788
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89884378
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89357787
159HOXB7_26014856_ChIP-Seq_BT474_Human0.88801199
160FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88355203
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88287495
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87678229
163SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87356776
164SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87003976
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.85492879
166TP53_20018659_ChIP-ChIP_R1E_Mouse0.84769803
167STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84457627
168SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84276048
169AR_21572438_ChIP-Seq_LNCaP_Human0.84130957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.45822831
2MP0003705_abnormal_hypodermis_morpholog3.87217777
3MP0002139_abnormal_hepatobiliary_system3.76603279
4MP0003300_gastrointestinal_ulcer3.20555175
5MP0005085_abnormal_gallbladder_physiolo3.17475136
6MP0003646_muscle_fatigue3.00522141
7MP0005365_abnormal_bile_salt2.93370654
8MP0003252_abnormal_bile_duct2.76240926
9MP0009840_abnormal_foam_cell2.66743239
10MP0009053_abnormal_anal_canal2.66069088
11MP0002876_abnormal_thyroid_physiology2.59624161
12MP0000383_abnormal_hair_follicle2.48014992
13MP0010234_abnormal_vibrissa_follicle2.45573238
14MP0010352_gastrointestinal_tract_polyps2.38596822
15MP0003950_abnormal_plasma_membrane2.32464875
16MP0002837_dystrophic_cardiac_calcinosis2.27009375
17MP0003303_peritoneal_inflammation2.25156940
18MP0010329_abnormal_lipoprotein_level2.19509619
19MP0010678_abnormal_skin_adnexa2.11934762
20MP0001666_abnormal_nutrient_absorption2.10259193
21MP0002877_abnormal_melanocyte_morpholog2.07234395
22MP0000427_abnormal_hair_cycle2.04874969
23MP0008875_abnormal_xenobiotic_pharmacok2.01252991
24MP0004130_abnormal_muscle_cell1.92477631
25MP0003191_abnormal_cellular_cholesterol1.91962228
26MP0009780_abnormal_chondrocyte_physiolo1.91605642
27MP0000467_abnormal_esophagus_morphology1.87494549
28MP0005083_abnormal_biliary_tract1.86725413
29MP0005646_abnormal_pituitary_gland1.85174579
30MP0003566_abnormal_cell_adhesion1.82333796
31MP0005076_abnormal_cell_differentiation1.72077793
32MP0005409_darkened_coat_color1.71964094
33MP0002138_abnormal_hepatobiliary_system1.68780596
34MP0008872_abnormal_physiological_respon1.68552232
35MP0004272_abnormal_basement_membrane1.67532199
36MP0000609_abnormal_liver_physiology1.65179154
37MP0002098_abnormal_vibrissa_morphology1.64997333
38MP0000579_abnormal_nail_morphology1.63347529
39MP0000537_abnormal_urethra_morphology1.62609937
40MP0004185_abnormal_adipocyte_glucose1.60962207
41MP0000538_abnormal_urinary_bladder1.60952859
42MP0005257_abnormal_intraocular_pressure1.58348335
43MP0008961_abnormal_basal_metabolism1.57949159
44MP0004233_abnormal_muscle_weight1.55923174
45MP0000534_abnormal_ureter_morphology1.46617807
46MP0003806_abnormal_nucleotide_metabolis1.45702652
47MP0001879_abnormal_lymphatic_vessel1.43726887
48MP0004510_myositis1.43319688
49MP0004084_abnormal_cardiac_muscle1.42578976
50MP0003942_abnormal_urinary_system1.38922086
51MP0002234_abnormal_pharynx_morphology1.38831257
52MP0003436_decreased_susceptibility_to1.38055042
53MP0000470_abnormal_stomach_morphology1.36464609
54MP0004885_abnormal_endolymph1.35395425
55MP0001348_abnormal_lacrimal_gland1.32809362
56MP0010771_integument_phenotype1.32717995
57MP0005666_abnormal_adipose_tissue1.32234155
58MP0002118_abnormal_lipid_homeostasis1.31095606
59MP0004087_abnormal_muscle_fiber1.31078007
60MP0008438_abnormal_cutaneous_collagen1.30729187
61MP0005275_abnormal_skin_tensile1.28331550
62MP0000230_abnormal_systemic_arterial1.27778302
63MP0004134_abnormal_chest_morphology1.27579139
64MP0001765_abnormal_ion_homeostasis1.26778495
65MP0002160_abnormal_reproductive_system1.22058576
66MP0003011_delayed_dark_adaptation1.22019656
67MP0000678_abnormal_parathyroid_gland1.21464669
68MP0009250_abnormal_appendicular_skeleto1.20524447
69MP0001661_extended_life_span1.20389427
70MP0001968_abnormal_touch/_nociception1.20229538
71MP0005330_cardiomyopathy1.20223270
72MP0005375_adipose_tissue_phenotype1.19562077
73MP0003879_abnormal_hair_cell1.19202413
74MP0004947_skin_inflammation1.19049597
75MP0001664_abnormal_digestion1.18913391
76MP0004858_abnormal_nervous_system1.18596119
77MP0005023_abnormal_wound_healing1.18329250
78MP0005332_abnormal_amino_acid1.17414207
79MP0000003_abnormal_adipose_tissue1.16506527
80MP0010630_abnormal_cardiac_muscle1.15630448
81MP0001944_abnormal_pancreas_morphology1.11721259
82MP0001216_abnormal_epidermal_layer1.11624154
83MP0005319_abnormal_enzyme/_coenzyme1.10980083
84MP0002166_altered_tumor_susceptibility1.10930652
85MP0004264_abnormal_extraembryonic_tissu1.08985263
86MP0001919_abnormal_reproductive_system1.08898107
87MP0003315_abnormal_perineum_morphology1.06827512
88MP0002269_muscular_atrophy1.06553815
89MP0010368_abnormal_lymphatic_system1.05626266
90MP0000013_abnormal_adipose_tissue1.05340605
91MP0003091_abnormal_cell_migration1.04586927
92MP0004381_abnormal_hair_follicle1.04565680
93MP0003959_abnormal_lean_body1.04558012
94MP0002909_abnormal_adrenal_gland1.04223686
95MP0005389_reproductive_system_phenotype1.03761429
96MP0002796_impaired_skin_barrier1.02518367
97MP0000685_abnormal_immune_system1.02226266
98MP0009278_abnormal_bone_marrow1.01894245
99MP0000747_muscle_weakness0.99941412
100MP0005503_abnormal_tendon_morphology0.99861535
101MP0009643_abnormal_urine_homeostasis0.99855097
102MP0000751_myopathy0.99077653
103MP0003936_abnormal_reproductive_system0.97048126
104MP0003279_aneurysm0.95977990
105MP0000377_abnormal_hair_follicle0.95971694
106MP0003183_abnormal_peptide_metabolism0.95625021
107MP0005167_abnormal_blood-brain_barrier0.94610819
108MP0010155_abnormal_intestine_physiology0.94265114
109MP0001756_abnormal_urination0.93668353
110MP0000767_abnormal_smooth_muscle0.92124632
111MP0000627_abnormal_mammary_gland0.91470768
112MP0003868_abnormal_feces_composition0.90852339
113MP0000604_amyloidosis0.90732815
114MP0000598_abnormal_liver_morphology0.90710413
115MP0001849_ear_inflammation0.89813162
116MP0003195_calcinosis0.89712431
117MP0003453_abnormal_keratinocyte_physiol0.89624603
118MP0004036_abnormal_muscle_relaxation0.87285762
119MP0010386_abnormal_urinary_bladder0.87175025
120MP0009384_cardiac_valve_regurgitation0.86865284
121MP0000613_abnormal_salivary_gland0.86396821
122MP0005584_abnormal_enzyme/coenzyme_acti0.86090248
123MP0002078_abnormal_glucose_homeostasis0.86089826
124MP0005220_abnormal_exocrine_pancreas0.85817976
125MP0004145_abnormal_muscle_electrophysio0.85397778
126MP0004782_abnormal_surfactant_physiolog0.85034136
127MP0001533_abnormal_skeleton_physiology0.84985778
128MP0000163_abnormal_cartilage_morphology0.83702524
129MP0005166_decreased_susceptibility_to0.83183735
130MP0000733_abnormal_muscle_development0.82071018
131MP0005387_immune_system_phenotype0.82020490
132MP0001790_abnormal_immune_system0.82020490
133MP0005501_abnormal_skin_physiology0.81341973
134MP0000762_abnormal_tongue_morphology0.81319231
135MP0005385_cardiovascular_system_phenoty0.80653612
136MP0001544_abnormal_cardiovascular_syste0.80653612
137MP0006054_spinal_hemorrhage0.80572123
138MP0002089_abnormal_postnatal_growth/wei0.80322596
139MP0005670_abnormal_white_adipose0.80156086
140MP0003045_fibrosis0.79509227
141MP0001873_stomach_inflammation0.79261849
142MP0002693_abnormal_pancreas_physiology0.79102292
143MP0003283_abnormal_digestive_organ0.77865654
144MP0000367_abnormal_coat/_hair0.77012827
145MP0002972_abnormal_cardiac_muscle0.74260265
146MP0005334_abnormal_fat_pad0.74204481
147MP0002108_abnormal_muscle_morphology0.73334300
148MP0002933_joint_inflammation0.73127614
149MP0001502_abnormal_circadian_rhythm0.73115621
150MP0002735_abnormal_chemical_nociception0.72975413
151MP0002896_abnormal_bone_mineralization0.72883424
152MP0010307_abnormal_tumor_latency0.72447936
153MP0001270_distended_abdomen0.72345132
154MP0004043_abnormal_pH_regulation0.71595608
155MP0001845_abnormal_inflammatory_respons0.70867854
156MP0002254_reproductive_system_inflammat0.70716200
157MP0005058_abnormal_lysosome_morphology0.70581803
158MP0001958_emphysema0.69785092
159MP0005464_abnormal_platelet_physiology0.67930109
160MP0008775_abnormal_heart_ventricle0.66457475
161MP0002971_abnormal_brown_adipose0.66402659
162MP0000759_abnormal_skeletal_muscle0.66193118
163MP0005623_abnormal_meninges_morphology0.64703408
164MP0003075_altered_response_to0.64356783
165MP0001800_abnormal_humoral_immune0.64337617
166MP0009763_increased_sensitivity_to0.64008009
167MP0001853_heart_inflammation0.63334871
168MP0002060_abnormal_skin_morphology0.62342465

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)4.04619796
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.04619796
3Deep venous thrombosis (HP:0002625)3.82700152
4Abnormality of the 1st metacarpal (HP:0010009)3.50193949
5Xanthomatosis (HP:0000991)3.39063618
6Intrahepatic cholestasis (HP:0001406)3.14400289
7Clumsiness (HP:0002312)3.09140795
8Genetic anticipation (HP:0003743)3.02962151
9Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94045143
10Right ventricular cardiomyopathy (HP:0011663)2.91208766
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.90587012
12Abnormality of the common coagulation pathway (HP:0010990)2.88204962
13Hypoglycemic coma (HP:0001325)2.85440290
14Concave nail (HP:0001598)2.84962270
15Follicular hyperkeratosis (HP:0007502)2.80985294
16Keratoconus (HP:0000563)2.80257912
17Increased corneal curvature (HP:0100692)2.80257912
18Exercise-induced muscle cramps (HP:0003710)2.72860583
19Hyporeflexia of lower limbs (HP:0002600)2.69027251
20Abnormality of the nasal septum (HP:0000419)2.68447628
21Cerebral aneurysm (HP:0004944)2.65723188
22Hyperventilation (HP:0002883)2.65575609
23Increased connective tissue (HP:0009025)2.64861975
24Myocardial infarction (HP:0001658)2.64362108
25Morphological abnormality of the middle ear (HP:0008609)2.64297409
26Hypobetalipoproteinemia (HP:0003563)2.60632261
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56181781
28Complement deficiency (HP:0004431)2.54437088
29Congenital stationary night blindness (HP:0007642)2.53152861
30Myoglobinuria (HP:0002913)2.52958487
31Lip pit (HP:0100267)2.50176598
32Radial bowing (HP:0002986)2.49819069
33Abnormality of the proximal phalanges of the hand (HP:0009834)2.49468562
34Short hallux (HP:0010109)2.48113020
35Hypoalphalipoproteinemia (HP:0003233)2.46323485
36Hypoplasia of the odontoid process (HP:0003311)2.42348976
37Hypolipoproteinemia (HP:0010981)2.41326410
38Aneurysm (HP:0002617)2.40963527
39Ketosis (HP:0001946)2.39991233
40Hyperglycemia (HP:0003074)2.37973726
41Hyperlipoproteinemia (HP:0010980)2.36725965
42Mitral valve prolapse (HP:0001634)2.35530404
43Ketoacidosis (HP:0001993)2.35273620
44Skin nodule (HP:0200036)2.34828790
45Abnormality of the Achilles tendon (HP:0005109)2.32958465
46Short phalanx of the thumb (HP:0009660)2.32745908
47Hyperinsulinemic hypoglycemia (HP:0000825)2.31647043
48Exercise-induced myalgia (HP:0003738)2.30349424
49Protrusio acetabuli (HP:0003179)2.29383937
50Tented upper lip vermilion (HP:0010804)2.29261722
51Ventricular tachycardia (HP:0004756)2.29240995
52Hyperammonemia (HP:0001987)2.29177167
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29060712
54Abnormality of alanine metabolism (HP:0010916)2.29060712
55Hyperalaninemia (HP:0003348)2.29060712
56Chorioretinal atrophy (HP:0000533)2.27146757
57Tubular atrophy (HP:0000092)2.26817626
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26384411
59Atrophic scars (HP:0001075)2.26318687
60J-shaped sella turcica (HP:0002680)2.24180942
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22457164
62Sudden death (HP:0001699)2.20415054
63Decreased subcutaneous fat (HP:0001002)2.19936808
64Esophageal varix (HP:0002040)2.19678928
65Fragile nails (HP:0001808)2.19589915
66Spastic diplegia (HP:0001264)2.18449382
67Fibular aplasia (HP:0002990)2.17289509
68Epidermoid cyst (HP:0200040)2.17116512
69Protruding tongue (HP:0010808)2.16907963
70Abnormality of the renal cortex (HP:0011035)2.15960099
71Large for gestational age (HP:0001520)2.15867607
72Aortic dissection (HP:0002647)2.15476301
73Abnormality of the intrinsic pathway (HP:0010989)2.14597530
74Achilles tendon contracture (HP:0001771)2.13859363
75Cardiovascular calcification (HP:0011915)2.13765530
76Vascular calcification (HP:0004934)2.11927384
77Abnormality of complement system (HP:0005339)2.11773059
78Shawl scrotum (HP:0000049)2.10001397
79Aortic aneurysm (HP:0004942)2.09956711
80Aplasia/Hypoplasia of the hallux (HP:0008362)2.09904828
81Abnormality of the odontoid process (HP:0003310)2.09199271
82Alopecia of scalp (HP:0002293)2.08697884
83Back pain (HP:0003418)2.08283626
84Arterial tortuosity (HP:0005116)2.06571598
85Fragile skin (HP:0001030)2.05903484
86Bladder diverticulum (HP:0000015)2.05305752
87Abnormality of nail color (HP:0100643)2.04180537
88Lymphangioma (HP:0100764)2.03912573
89Dysmetric saccades (HP:0000641)2.03704232
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.03124708
91Hypoglycemic seizures (HP:0002173)2.02587893
92Amelogenesis imperfecta (HP:0000705)2.02468794
93Fused cervical vertebrae (HP:0002949)2.02086200
94Menorrhagia (HP:0000132)2.01490598
95Hyperglycinuria (HP:0003108)2.00201085
96Hydroxyprolinuria (HP:0003080)1.99674931
97Abnormality of proline metabolism (HP:0010907)1.99674931
98Oligodontia (HP:0000677)1.99168636
99Obstructive sleep apnea (HP:0002870)1.97240336
100Flat acetabular roof (HP:0003180)1.96860539
101Increased mean platelet volume (HP:0011877)1.95704125
102Pancreatic cysts (HP:0001737)1.95219572
103Asymmetric septal hypertrophy (HP:0001670)1.94639023
104Congenital sensorineural hearing impairment (HP:0008527)1.94241787
105Distal lower limb amyotrophy (HP:0008944)1.94224263
106Abnormality of serine family amino acid metabolism (HP:0010894)1.92665335
107Abnormality of glycine metabolism (HP:0010895)1.92665335
108Mitral stenosis (HP:0001718)1.91390822
109Hyperacusis (HP:0010780)1.91308899
110Bundle branch block (HP:0011710)1.90696230
111Abnormal foot bone ossification (HP:0010675)1.90599787
112Cheilitis (HP:0100825)1.90393351
113Sparse lateral eyebrow (HP:0005338)1.89963377
114Polycythemia (HP:0001901)1.89783264
115Vascular tortuosity (HP:0004948)1.88989953
116Abnormality of subcutaneous fat tissue (HP:0001001)1.88779373
117Natal tooth (HP:0000695)1.87588170
118Abnormal platelet volume (HP:0011876)1.86994559
119Difficulty running (HP:0009046)1.86249177
120Bowed forearm bones (HP:0003956)1.86149538
121Bowing of the arm (HP:0006488)1.86149538
122Abnormality of the distal phalanges of the toes (HP:0010182)1.85045359
123Short femoral neck (HP:0100864)1.83398965
124Upper limb amyotrophy (HP:0009129)1.83107302
125Distal upper limb amyotrophy (HP:0007149)1.83107302
126Long toe (HP:0010511)1.83083770
127Hamartoma of the eye (HP:0010568)1.82831515
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82372278
129Tibial bowing (HP:0002982)1.82214737
130Milia (HP:0001056)1.82149527
131Dilatation of the ascending aorta (HP:0005111)1.81760814
132Soft skin (HP:0000977)1.81759691
133Increased density of long bones (HP:0006392)1.78625932
134Type II lissencephaly (HP:0007260)1.78513505
135Fat malabsorption (HP:0002630)1.78389448
136Hematochezia (HP:0002573)1.78135345
137Aplasia/Hypoplasia of the patella (HP:0006498)1.78132669
138Premature rupture of membranes (HP:0001788)1.77068859
139Severe muscular hypotonia (HP:0006829)1.76762408
140Peritonitis (HP:0002586)1.76653819
141Hypercholesterolemia (HP:0003124)1.76486564
142Abnormality of the renal collecting system (HP:0004742)1.76381738
143Resting tremor (HP:0002322)1.75852250
144Joint hemorrhage (HP:0005261)1.75143745
145Rhabdomyolysis (HP:0003201)1.75007566
146Difficulty climbing stairs (HP:0003551)1.74304332
147Macroorchidism (HP:0000053)1.73925023
148Abnormal cartilage morphology (HP:0002763)1.73810806
149Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.73169243
150Frequent falls (HP:0002359)1.72221211
151Pendular nystagmus (HP:0012043)1.72137462
152Gaze-evoked nystagmus (HP:0000640)1.72072346
153Abnormality of the pancreatic islet cells (HP:0006476)1.71991285
154Abnormality of endocrine pancreas physiology (HP:0012093)1.71991285
155Hypoplasia of dental enamel (HP:0006297)1.70993285
156Increased neuronal autofluorescent lipopigment (HP:0002074)1.70796504
157Decreased circulating renin level (HP:0003351)1.70732350
158Visceral angiomatosis (HP:0100761)1.70281228
159Subaortic stenosis (HP:0001682)1.69227257
160Abnormality of the left ventricular outflow tract (HP:0011103)1.69227257
161Atrioventricular block (HP:0001678)1.68840767
162Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67213384
163Aplasia/hypoplasia of the femur (HP:0005613)1.67095584
164Broad metatarsal (HP:0001783)1.66567157
165Prolonged partial thromboplastin time (HP:0003645)1.66479997
166Conical tooth (HP:0000698)1.66107324
167Abnormality of purine metabolism (HP:0004352)1.65944838
168Ulnar bowing (HP:0003031)1.65914489
169Muscle fiber splitting (HP:0003555)1.65537693
170Mildly elevated creatine phosphokinase (HP:0008180)1.65448840
171Plantar hyperkeratosis (HP:0007556)1.65251951
172Slender long bone (HP:0003100)1.64892872
173Spontaneous hematomas (HP:0007420)1.64417358
174Hand muscle atrophy (HP:0009130)1.63697326
175Striae distensae (HP:0001065)1.63348481
176Ovoid vertebral bodies (HP:0003300)1.62647396
177Furrowed tongue (HP:0000221)1.62596091
178Reduced subcutaneous adipose tissue (HP:0003758)1.62588872
179Colitis (HP:0002583)1.62440739
180Rectal prolapse (HP:0002035)1.62400480
181Abnormality of the radial head (HP:0003995)1.62061613
182Abnormal tarsal ossification (HP:0008369)1.62054940
183Hypoplastic ischia (HP:0003175)1.61855122
184EMG: myopathic abnormalities (HP:0003458)1.59096145
185Hemangiomatosis (HP:0007461)1.58842749
186Patellar aplasia (HP:0006443)1.58617249
187Increased variability in muscle fiber diameter (HP:0003557)1.58139097
188Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.57350128
189Bulbous nose (HP:0000414)1.57141858
190Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.55801865
191Blue sclerae (HP:0000592)1.55362416
192Dysostosis multiplex (HP:0000943)1.54657662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.74279997
2PKN24.09420901
3TTN3.53735097
4ERN13.52822686
5MAPKAPK33.14580324
6MAP3K102.70780237
7GRK12.51028596
8RIPK12.42031163
9WNK42.38225530
10PTK62.27356472
11EEF2K2.23391950
12ADRBK22.17237862
13MUSK2.07000887
14PRKD22.00965970
15SIK11.99822007
16FGFR41.92297285
17MAP2K31.88984061
18FRK1.79241976
19MAP4K11.78851273
20AKT31.72428835
21MAP3K71.65663726
22FGFR31.58784049
23PDGFRA1.57046979
24CDK121.48708594
25GRK61.45716738
26STK391.44415523
27TLK11.42853916
28DMPK1.40997836
29MAP2K11.40897204
30MAP3K31.40421427
31STK381.38215459
32JAK11.33164936
33BMPR1B1.33085020
34ADRBK11.32925956
35LRRK21.30013446
36LATS11.27537561
37EPHB11.27092639
38ALK1.24337143
39FLT31.23841132
40BCKDK1.18531074
41SCYL21.18187261
42LMTK21.17754576
43TAOK11.17515851
44CAMK1D1.15403379
45RET1.13889230
46PRKCH1.09936120
47PRKCI1.09650292
48STK101.09508926
49BMX1.03521780
50TYK21.03005662
51TAOK31.02754971
52MAP2K61.00953022
53PIK3CA1.00608680
54ZAP700.99745462
55PTK2B0.99175841
56ITK0.97705991
57JAK20.96946335
58MAP3K20.95575245
59TGFBR20.95138707
60MAP3K10.92647876
61RPS6KA60.92022777
62TBK10.90953946
63KSR20.90221599
64SMG10.88386536
65CAMK1G0.85755627
66MYLK0.83197261
67PTK20.83059165
68CDK60.82061499
69MTOR0.81691666
70ACVR1B0.81495022
71PDGFRB0.81086812
72STK240.79994526
73PAK30.78149646
74ILK0.74600700
75IRAK30.74212558
76IKBKB0.74005125
77MAP3K90.73675573
78CSK0.73053889
79MAP2K20.72928192
80IRAK10.71640831
81JAK30.71189108
82WNK10.69182185
83SIK20.68786417
84CAMKK10.68185317
85MAP3K140.68134277
86MAPKAPK50.68004265
87FGFR20.67827749
88EPHA30.67272890
89HCK0.64390578
90PRKD30.64188457
91FGFR10.64128319
92PINK10.61960477
93HIPK20.61858460
94SIK30.61487875
95CDK40.61143703
96CDC42BPA0.61011404
97PRKD10.60532545
98RPS6KL10.60077714
99RPS6KC10.60077714
100SGK30.59535944
101MAP3K80.59094214
102PRKG20.57616807
103DDR20.57400689
104PDK10.56860072
105MELK0.56660995
106STK30.55606065
107PHKG20.55118735
108PHKG10.55118735
109PAK20.54237098
110PDPK10.52581800
111TNK20.50890764
112PRKCE0.48821866
113STK110.48399451
114PRKAA10.48359200
115PRKAA20.47164146
116CHUK0.47145981
117CASK0.46494297
118CDK80.45525716
119RPS6KB20.45504629
120MAP3K50.44754521
121EIF2AK10.44675247
122NEK10.44090588
123CDK90.43592044
124INSRR0.43251713
125MAP2K40.42955206
126NEK90.42823193
127RPS6KB10.42339946
128MARK20.42194712
129LATS20.41346385
130MAPK110.41268936
131MAPKAPK20.41178822
132GSK3A0.40838779
133PRKCZ0.40326824
134PAK40.40101974
135ICK0.38807987
136PIM20.37945165
137MST1R0.37854102
138EPHB20.37807946
139SGK20.37434920
140MAP3K110.37352321
141MET0.36413014
142TRPM70.36132970
143TGFBR10.36041344
144EPHA20.35921783
145RPS6KA20.35793796
146BTK0.35306312
147CSF1R0.35034471
148PIK3CG0.34081015
149FER0.33517519
150MST40.33501534
151EGFR0.31519899
152CAMK40.31214359

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.75897059
2Nitrogen metabolism_Homo sapiens_hsa009103.43517355
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.31211820
4Arginine biosynthesis_Homo sapiens_hsa002202.73083054
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.36341865
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18660436
7Fatty acid degradation_Homo sapiens_hsa000712.12400680
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09156036
9ECM-receptor interaction_Homo sapiens_hsa045122.04158545
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96875821
11Tryptophan metabolism_Homo sapiens_hsa003801.85201277
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83350451
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80214331
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64077256
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63463164
16Complement and coagulation cascades_Homo sapiens_hsa046101.60795188
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59666950
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56631275
19Fat digestion and absorption_Homo sapiens_hsa049751.55466627
20Starch and sucrose metabolism_Homo sapiens_hsa005001.54926428
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53038892
22Bile secretion_Homo sapiens_hsa049761.51830093
23PPAR signaling pathway_Homo sapiens_hsa033201.51445535
24Butanoate metabolism_Homo sapiens_hsa006501.51061623
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.48384172
26Caffeine metabolism_Homo sapiens_hsa002321.47499311
27Insulin resistance_Homo sapiens_hsa049311.45915002
28Phototransduction_Homo sapiens_hsa047441.45023475
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37002307
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33346012
31Staphylococcus aureus infection_Homo sapiens_hsa051501.32801192
32Fatty acid metabolism_Homo sapiens_hsa012121.32536546
33Linoleic acid metabolism_Homo sapiens_hsa005911.31917416
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28059885
35Melanoma_Homo sapiens_hsa052181.26275095
36Lysine degradation_Homo sapiens_hsa003101.25726096
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25659031
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20824222
39Carbon metabolism_Homo sapiens_hsa012001.17323499
40Type II diabetes mellitus_Homo sapiens_hsa049301.16897003
41Ovarian steroidogenesis_Homo sapiens_hsa049131.16344057
42ABC transporters_Homo sapiens_hsa020101.12193398
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.12169089
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.10384842
45Selenocompound metabolism_Homo sapiens_hsa004501.10177220
46Propanoate metabolism_Homo sapiens_hsa006401.07842557
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06613567
48Sphingolipid metabolism_Homo sapiens_hsa006001.03929815
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03314756
50Ether lipid metabolism_Homo sapiens_hsa005651.01762238
51Biosynthesis of amino acids_Homo sapiens_hsa012301.00222614
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00152394
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.97363932
54N-Glycan biosynthesis_Homo sapiens_hsa005100.96941073
55Insulin secretion_Homo sapiens_hsa049110.96853116
56Circadian rhythm_Homo sapiens_hsa047100.95576198
57Prostate cancer_Homo sapiens_hsa052150.91875790
58Chronic myeloid leukemia_Homo sapiens_hsa052200.90954949
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88558550
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86119952
61Dilated cardiomyopathy_Homo sapiens_hsa054140.85786793
62Insulin signaling pathway_Homo sapiens_hsa049100.81413840
63Calcium signaling pathway_Homo sapiens_hsa040200.81346844
64beta-Alanine metabolism_Homo sapiens_hsa004100.80794196
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80782551
66Osteoclast differentiation_Homo sapiens_hsa043800.79377303
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79040972
68TGF-beta signaling pathway_Homo sapiens_hsa043500.78816264
69AMPK signaling pathway_Homo sapiens_hsa041520.78679466
70Hippo signaling pathway_Homo sapiens_hsa043900.78209562
71Phenylalanine metabolism_Homo sapiens_hsa003600.77946170
72Long-term depression_Homo sapiens_hsa047300.77462144
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.76855222
74mTOR signaling pathway_Homo sapiens_hsa041500.76816803
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.76549951
76Thyroid hormone synthesis_Homo sapiens_hsa049180.75702539
77Focal adhesion_Homo sapiens_hsa045100.75199897
78MAPK signaling pathway_Homo sapiens_hsa040100.74835846
79Pancreatic secretion_Homo sapiens_hsa049720.74725439
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.74715447
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74330968
82Galactose metabolism_Homo sapiens_hsa000520.73494346
83Bladder cancer_Homo sapiens_hsa052190.73403115
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73152801
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73065307
86Adherens junction_Homo sapiens_hsa045200.72110080
87Viral myocarditis_Homo sapiens_hsa054160.72000854
88Mineral absorption_Homo sapiens_hsa049780.71066811
89Prion diseases_Homo sapiens_hsa050200.69998213
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69709631
91Peroxisome_Homo sapiens_hsa041460.69588826
92Amoebiasis_Homo sapiens_hsa051460.69552143
93Glucagon signaling pathway_Homo sapiens_hsa049220.68990518
94Proteoglycans in cancer_Homo sapiens_hsa052050.68430276
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68304678
96Cholinergic synapse_Homo sapiens_hsa047250.66704526
97Choline metabolism in cancer_Homo sapiens_hsa052310.66450927
98B cell receptor signaling pathway_Homo sapiens_hsa046620.66419896
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.66242183
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66130789
101Salivary secretion_Homo sapiens_hsa049700.65981454
102Serotonergic synapse_Homo sapiens_hsa047260.65577055
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64786255
104Toxoplasmosis_Homo sapiens_hsa051450.64289853
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63811093
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63778632
107Fructose and mannose metabolism_Homo sapiens_hsa000510.63079337
108Non-small cell lung cancer_Homo sapiens_hsa052230.62580616
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62199860
110Axon guidance_Homo sapiens_hsa043600.61888208
111ErbB signaling pathway_Homo sapiens_hsa040120.61265174
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.60699290
113VEGF signaling pathway_Homo sapiens_hsa043700.59976658
114Pyruvate metabolism_Homo sapiens_hsa006200.59691921
115Sulfur metabolism_Homo sapiens_hsa009200.59547614
116Dorso-ventral axis formation_Homo sapiens_hsa043200.58585002
117Circadian entrainment_Homo sapiens_hsa047130.58444316
118Prolactin signaling pathway_Homo sapiens_hsa049170.58069734
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57696878
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.57543203
121Oxytocin signaling pathway_Homo sapiens_hsa049210.56856469
122Pathways in cancer_Homo sapiens_hsa052000.56698899
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.56531811
124Leishmaniasis_Homo sapiens_hsa051400.56423582
125Gastric acid secretion_Homo sapiens_hsa049710.55814127
126Glycerolipid metabolism_Homo sapiens_hsa005610.55523328
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54744960
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53472640
129Ras signaling pathway_Homo sapiens_hsa040140.53330209
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52933544
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.52552430
132Glutamatergic synapse_Homo sapiens_hsa047240.52377047
133One carbon pool by folate_Homo sapiens_hsa006700.52009410
134GnRH signaling pathway_Homo sapiens_hsa049120.51995770
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50970882
136Renin secretion_Homo sapiens_hsa049240.50864323
137Histidine metabolism_Homo sapiens_hsa003400.50212785
138Acute myeloid leukemia_Homo sapiens_hsa052210.49354161
139Small cell lung cancer_Homo sapiens_hsa052220.49091783
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49068747
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48533021
142T cell receptor signaling pathway_Homo sapiens_hsa046600.48125077
143Arginine and proline metabolism_Homo sapiens_hsa003300.46339434
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45964901
145Pancreatic cancer_Homo sapiens_hsa052120.45942490
146Platelet activation_Homo sapiens_hsa046110.45517379
147Protein digestion and absorption_Homo sapiens_hsa049740.45215150
148Fatty acid biosynthesis_Homo sapiens_hsa000610.43117863
149Endometrial cancer_Homo sapiens_hsa052130.42914570
150Renal cell carcinoma_Homo sapiens_hsa052110.41004913
151Glioma_Homo sapiens_hsa052140.40324158
152Estrogen signaling pathway_Homo sapiens_hsa049150.39893107
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39003456
154FoxO signaling pathway_Homo sapiens_hsa040680.38159783
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37754985
156TNF signaling pathway_Homo sapiens_hsa046680.37525184
157Chemical carcinogenesis_Homo sapiens_hsa052040.36975735

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