SLC35D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.96439954
2L-phenylalanine catabolic process (GO:0006559)6.96439954
3L-phenylalanine metabolic process (GO:0006558)6.56945170
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.56945170
5aromatic amino acid family catabolic process (GO:0009074)6.50359347
6indole-containing compound catabolic process (GO:0042436)6.11235821
7indolalkylamine catabolic process (GO:0046218)6.11235821
8tryptophan catabolic process (GO:0006569)6.11235821
9* cellular glucuronidation (GO:0052695)5.82043414
10tryptophan metabolic process (GO:0006568)5.77694380
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75002114
12kynurenine metabolic process (GO:0070189)5.73525158
13bile acid biosynthetic process (GO:0006699)5.68005898
14omega-hydroxylase P450 pathway (GO:0097267)5.64990114
15cysteine metabolic process (GO:0006534)5.49875983
16glyoxylate metabolic process (GO:0046487)5.43663487
17* glucuronate metabolic process (GO:0019585)5.42239504
18* uronic acid metabolic process (GO:0006063)5.42239504
19high-density lipoprotein particle remodeling (GO:0034375)5.25088018
20sulfur amino acid catabolic process (GO:0000098)5.24452003
21urea metabolic process (GO:0019627)5.14068535
22urea cycle (GO:0000050)5.14068535
23drug metabolic process (GO:0017144)5.04417942
24alpha-linolenic acid metabolic process (GO:0036109)4.99651680
25response to nitrosative stress (GO:0051409)4.96611136
26bile acid metabolic process (GO:0008206)4.93214730
27negative regulation of fibrinolysis (GO:0051918)4.90059739
28regulation of fibrinolysis (GO:0051917)4.88776034
29protein carboxylation (GO:0018214)4.88152917
30peptidyl-glutamic acid carboxylation (GO:0017187)4.88152917
31regulation of protein activation cascade (GO:2000257)4.82546103
32complement activation, alternative pathway (GO:0006957)4.77333684
33regulation of cholesterol esterification (GO:0010872)4.74317017
34serine family amino acid catabolic process (GO:0009071)4.70114255
35nitrogen cycle metabolic process (GO:0071941)4.68198105
36amino-acid betaine metabolic process (GO:0006577)4.67136568
37aromatic amino acid family metabolic process (GO:0009072)4.66886157
38reverse cholesterol transport (GO:0043691)4.64987379
39bile acid and bile salt transport (GO:0015721)4.62481086
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58344351
41oxidative demethylation (GO:0070989)4.56898143
42homocysteine metabolic process (GO:0050667)4.54381562
43protein-lipid complex remodeling (GO:0034368)4.53494458
44macromolecular complex remodeling (GO:0034367)4.53494458
45plasma lipoprotein particle remodeling (GO:0034369)4.53494458
46regulation of complement activation (GO:0030449)4.48634789
47benzene-containing compound metabolic process (GO:0042537)4.46815165
48phenylpropanoid metabolic process (GO:0009698)4.45007933
49phospholipid efflux (GO:0033700)4.44785513
50regulation of triglyceride catabolic process (GO:0010896)4.44515698
51tyrosine metabolic process (GO:0006570)4.42936700
52intestinal absorption (GO:0050892)4.40491800
53triglyceride homeostasis (GO:0070328)4.39841410
54acylglycerol homeostasis (GO:0055090)4.39841410
55amine catabolic process (GO:0009310)4.39170796
56cellular biogenic amine catabolic process (GO:0042402)4.39170796
57negative regulation of protein activation cascade (GO:2000258)4.37553424
58alpha-amino acid catabolic process (GO:1901606)4.36611968
59indolalkylamine metabolic process (GO:0006586)4.34639896
60drug catabolic process (GO:0042737)4.33497031
61hormone catabolic process (GO:0042447)4.29947066
62flavonoid metabolic process (GO:0009812)4.26571441
63xenobiotic catabolic process (GO:0042178)4.20452873
64lysine metabolic process (GO:0006553)4.17447143
65lysine catabolic process (GO:0006554)4.17447143
66blood coagulation, intrinsic pathway (GO:0007597)4.15804992
67negative regulation of hemostasis (GO:1900047)4.13782188
68negative regulation of blood coagulation (GO:0030195)4.13782188
69negative regulation of cholesterol transport (GO:0032375)4.11191706
70negative regulation of sterol transport (GO:0032372)4.11191706
71low-density lipoprotein particle remodeling (GO:0034374)4.10564250
72coenzyme catabolic process (GO:0009109)4.07862948
73imidazole-containing compound metabolic process (GO:0052803)4.07417279
74glutamate metabolic process (GO:0006536)4.06176869
75regulation of plasminogen activation (GO:0010755)4.04545811
76cellular amino acid catabolic process (GO:0009063)4.02458119
77exogenous drug catabolic process (GO:0042738)3.99533901
78cholesterol efflux (GO:0033344)3.99299951
79serine family amino acid metabolic process (GO:0009069)3.98343980
80aldehyde catabolic process (GO:0046185)3.94135845
81cellular ketone body metabolic process (GO:0046950)3.92610538
82cellular modified amino acid catabolic process (GO:0042219)3.88868359
83regulation of bile acid biosynthetic process (GO:0070857)3.88433889
84negative regulation of lipase activity (GO:0060192)3.87619625
85dicarboxylic acid biosynthetic process (GO:0043650)3.85231501
86ethanol oxidation (GO:0006069)3.82748906
87fat-soluble vitamin biosynthetic process (GO:0042362)3.82467989
88negative regulation of coagulation (GO:0050819)3.81173363
89epoxygenase P450 pathway (GO:0019373)3.80804839
90glycine metabolic process (GO:0006544)3.80256995
91very-low-density lipoprotein particle assembly (GO:0034379)3.78992894
92negative regulation of wound healing (GO:0061045)3.78013762
93positive regulation of blood coagulation (GO:0030194)3.77234925
94positive regulation of hemostasis (GO:1900048)3.77234925
95protein activation cascade (GO:0072376)3.76740883
96plasma lipoprotein particle assembly (GO:0034377)3.75875537
97phospholipid homeostasis (GO:0055091)3.75718513
98serine family amino acid biosynthetic process (GO:0009070)3.75357788
99fibrinolysis (GO:0042730)3.75165286
100ethanol metabolic process (GO:0006067)3.74527872
101plasma lipoprotein particle clearance (GO:0034381)3.73897731
102positive regulation of coagulation (GO:0050820)3.67532974
103negative regulation of complement activation (GO:0045916)3.65967852
104NAD biosynthetic process (GO:0009435)3.65955659
105positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.65274289
106drug transport (GO:0015893)3.63339708
107arginine metabolic process (GO:0006525)3.63088085
108S-adenosylmethionine metabolic process (GO:0046500)3.62027812
109regulation of cholesterol homeostasis (GO:2000188)3.61792086
110complement activation, classical pathway (GO:0006958)3.60678939
111positive regulation of lipoprotein lipase activity (GO:0051006)3.60505495
112positive regulation of triglyceride lipase activity (GO:0061365)3.60505495
113drug transmembrane transport (GO:0006855)3.60324539
114cholesterol homeostasis (GO:0042632)3.59612347
115organic acid catabolic process (GO:0016054)3.58315713
116carboxylic acid catabolic process (GO:0046395)3.58315713
117intestinal cholesterol absorption (GO:0030299)3.56691932
118regulation of cholesterol biosynthetic process (GO:0045540)3.56482141
119carnitine metabolic process (GO:0009437)3.54633893
120pyridine nucleotide biosynthetic process (GO:0019363)3.54268733
121nicotinamide nucleotide biosynthetic process (GO:0019359)3.54268733
122sterol homeostasis (GO:0055092)3.54086286
123regulation of cholesterol metabolic process (GO:0090181)3.53767791
124plasma lipoprotein particle organization (GO:0071827)3.51869565
125regulation of humoral immune response (GO:0002920)3.48738243
126complement activation (GO:0006956)3.38369659
127alkaloid metabolic process (GO:0009820)3.35736661
128positive regulation of lipid catabolic process (GO:0050996)3.35477813
129doxorubicin metabolic process (GO:0044598)3.29399383
130daunorubicin metabolic process (GO:0044597)3.29399383
131polyketide metabolic process (GO:0030638)3.29399383
132acute-phase response (GO:0006953)3.23790535
133protein-lipid complex assembly (GO:0065005)3.22758215
134lipoprotein metabolic process (GO:0042157)3.15909488
135* xenobiotic metabolic process (GO:0006805)3.08112998
136negative regulation of lipid transport (GO:0032369)3.01276648
137protein-lipid complex subunit organization (GO:0071825)2.99990446
138heme transport (GO:0015886)2.99173268
139very long-chain fatty acid metabolic process (GO:0000038)2.94544802
140COPII vesicle coating (GO:0048208)2.92455196
141regulation of hemostasis (GO:1900046)2.92377455
142regulation of blood coagulation (GO:0030193)2.92377455
143androgen metabolic process (GO:0008209)2.91981110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.63153433
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.69930651
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.53308105
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.10381292
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.81863349
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.58436229
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92784711
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75177996
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67404089
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32106626
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12658644
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.41119437
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6711186
14TCF4_18268006_ChIP-ChIP_LS174T_Human1.97427366
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95804388
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.94172722
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90138868
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88682579
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80864705
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.77769763
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73516917
22TP53_16413492_ChIP-PET_HCT116_Human1.62925729
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57303581
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50285323
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46508308
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.45212082
27GATA1_22025678_ChIP-Seq_K562_Human1.44188466
28HTT_18923047_ChIP-ChIP_STHdh_Human1.43512678
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40312873
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39312757
31CLOCK_20551151_ChIP-Seq_293T_Human1.36803979
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34325562
33HNF4A_19822575_ChIP-Seq_HepG2_Human1.33559210
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.32138648
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31679653
36CJUN_26792858_Chip-Seq_BT549_Human1.31224762
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29920396
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28467979
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26910021
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24988890
41TP63_23658742_ChIP-Seq_EP156T_Human1.24513762
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23304116
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22530359
44* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22530359
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.22036609
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20870838
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20688826
48GATA4_25053715_ChIP-Seq_YYC3_Human1.14050222
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12858461
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12858461
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12693477
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11831739
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.10156946
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06330563
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.04670157
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04051195
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.03331639
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02641959
59RUNX_20019798_ChIP-Seq_JUKART_Human1.01992795
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01390427
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.00954856
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00236911
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.00050156
64E2F1_18555785_Chip-Seq_ESCs_Mouse0.99633158
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99231360
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99165088
67SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98943952
68TRIM28_21343339_ChIP-Seq_HEK293_Human0.98811554
69ESR1_20079471_ChIP-ChIP_T-47D_Human0.98248426
70AHR_22903824_ChIP-Seq_MCF-7_Human0.97920965
71OCT4_18555785_Chip-Seq_ESCs_Mouse0.97847787
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97096009
73CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96366087
74CMYC_18555785_Chip-Seq_ESCs_Mouse0.95498270
75P53_22387025_ChIP-Seq_ESCs_Mouse0.95296104
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94048682
77* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93594695
78RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93495635
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91675752
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91339341
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85927578
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85005338
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81208786
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.79758716
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79527244
86* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79371589
87TAF15_26573619_Chip-Seq_HEK293_Human0.79068627
88SOX2_20726797_ChIP-Seq_SW620_Human0.78983640
89AR_21572438_ChIP-Seq_LNCaP_Human0.76517162
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76369565
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75412446
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.75138696
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74769451
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.74137135
95BCAT_22108803_ChIP-Seq_LS180_Human0.69618952
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69022119
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68841728
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67379594
99KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67236273
100TP53_18474530_ChIP-ChIP_U2OS_Human0.65717089
101FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65540625
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.64908396
103* FOXA1_25552417_ChIP-Seq_VCAP_Human0.64469600
104FOXM1_26456572_ChIP-Seq_MCF-7_Human0.63368044
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.63247825
106EGR1_19032775_ChIP-ChIP_M12_Human0.63178763
107CDX2_22108803_ChIP-Seq_LS180_Human0.62949665
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.62292625
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.61850540
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61843637
111OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61839212
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.61794696
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.59399567
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.57595854
115GATA6_25053715_ChIP-Seq_YYC3_Human0.57158963
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57083812
117STAT1_17558387_ChIP-Seq_HELA_Human0.57050435
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54702993
119AR_20517297_ChIP-Seq_VCAP_Human0.54540857
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.53653967
121* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53548343
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.53511002
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.53287457
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52831616
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.52691466
126CBP_21632823_ChIP-Seq_H3396_Human0.51311893
127IRF1_19129219_ChIP-ChIP_H3396_Human0.51114598
128RUNX1_27457419_Chip-Seq_LIVER_Mouse0.51087610
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.50576146
130CEBPB_22108803_ChIP-Seq_LS180_Human0.49947254
131* GATA3_24758297_ChIP-Seq_MCF-7_Human0.49881075
132RXR_22108803_ChIP-Seq_LS180_Human0.48886300
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.48884382
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.47762728
135FOXH1_21741376_ChIP-Seq_EPCs_Human0.46638136
136GATA2_19941826_ChIP-Seq_K562_Human0.46592130
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.46507508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.82876577
2MP0005360_urolithiasis7.32250872
3MP0005085_abnormal_gallbladder_physiolo6.28085172
4MP0005365_abnormal_bile_salt6.17551614
5MP0008875_abnormal_xenobiotic_pharmacok5.92281541
6MP0003806_abnormal_nucleotide_metabolis3.86792365
7MP0003252_abnormal_bile_duct3.66347384
8MP0010329_abnormal_lipoprotein_level3.41868343
9MP0005332_abnormal_amino_acid2.75656820
10MP0009840_abnormal_foam_cell2.74190479
11MP0005083_abnormal_biliary_tract2.72097115
12MP0001666_abnormal_nutrient_absorption2.61917890
13MP0003195_calcinosis2.59740120
14MP0010234_abnormal_vibrissa_follicle2.13430060
15MP0004019_abnormal_vitamin_homeostasis2.09460198
16MP0000609_abnormal_liver_physiology1.92492039
17MP0002118_abnormal_lipid_homeostasis1.91619133
18MP0003191_abnormal_cellular_cholesterol1.90856852
19MP0002138_abnormal_hepatobiliary_system1.84636770
20MP0009697_abnormal_copulation1.75686744
21MP0010352_gastrointestinal_tract_polyps1.71369229
22MP0002254_reproductive_system_inflammat1.69711146
23MP0005319_abnormal_enzyme/_coenzyme1.69493499
24MP0003868_abnormal_feces_composition1.68835373
25MP0003183_abnormal_peptide_metabolism1.68166007
26MP0001764_abnormal_homeostasis1.65732852
27MP0003186_abnormal_redox_activity1.65354829
28MP0003950_abnormal_plasma_membrane1.47796841
29MP0005584_abnormal_enzyme/coenzyme_acti1.37432527
30MP0001661_extended_life_span1.35635838
31MP0003656_abnormal_erythrocyte_physiolo1.23185907
32MP0006054_spinal_hemorrhage1.22935032
33MP0005451_abnormal_body_composition1.20986594
34MP0003300_gastrointestinal_ulcer1.20477047
35MP0009643_abnormal_urine_homeostasis1.20381865
36MP0005647_abnormal_sex_gland1.20258309
37MP0003011_delayed_dark_adaptation1.16884412
38MP0005023_abnormal_wound_healing1.11741000
39MP0002132_abnormal_respiratory_system1.05158973
40MP0000598_abnormal_liver_morphology1.02415632
41MP0010155_abnormal_intestine_physiology1.00354418
42MP0010368_abnormal_lymphatic_system0.99068398
43MP0009764_decreased_sensitivity_to0.98725598
44MP0009053_abnormal_anal_canal0.96887559
45MP0004043_abnormal_pH_regulation0.91889877
46MP0009763_increased_sensitivity_to0.91870253
47MP0002876_abnormal_thyroid_physiology0.88849448
48MP0008438_abnormal_cutaneous_collagen0.88523866
49MP0009384_cardiac_valve_regurgitation0.88448262
50MP0002166_altered_tumor_susceptibility0.87905047
51MP0001915_intracranial_hemorrhage0.87253445
52MP0000566_synostosis0.84942734
53MP0009765_abnormal_xenobiotic_induced0.83039858
54MP0003705_abnormal_hypodermis_morpholog0.82611398
55MP0005408_hypopigmentation0.82525620
56MP0000685_abnormal_immune_system0.82309257
57MP0000013_abnormal_adipose_tissue0.81966292
58MP0005636_abnormal_mineral_homeostasis0.81862324
59MP0008789_abnormal_olfactory_epithelium0.81357651
60MP0010678_abnormal_skin_adnexa0.78236010
61MP0005499_abnormal_olfactory_system0.77867331
62MP0005394_taste/olfaction_phenotype0.77867331
63MP0005376_homeostasis/metabolism_phenot0.76107568
64MP0005084_abnormal_gallbladder_morpholo0.75665696
65MP0003690_abnormal_glial_cell0.75475986
66MP0003091_abnormal_cell_migration0.75312760
67MP0009642_abnormal_blood_homeostasis0.74606615
68MP0008469_abnormal_protein_level0.73756691
69MP0003763_abnormal_thymus_physiology0.73439660
70MP0001873_stomach_inflammation0.71589096
71MP0005670_abnormal_white_adipose0.70774261
72MP0005409_darkened_coat_color0.70529862
73MP0004782_abnormal_surfactant_physiolog0.68826898
74MP0004147_increased_porphyrin_level0.68235766
75MP0002009_preneoplasia0.67176879
76MP0003566_abnormal_cell_adhesion0.67020856
77MP0004381_abnormal_hair_follicle0.65840944
78MP0002822_catalepsy0.65020666
79MP0005266_abnormal_metabolism0.64212309
80MP0001756_abnormal_urination0.63748315
81MP0002168_other_aberrant_phenotype0.63743108
82MP0000465_gastrointestinal_hemorrhage0.63245283
83MP0002896_abnormal_bone_mineralization0.62717089
84MP0003866_abnormal_defecation0.62549353
85MP0005334_abnormal_fat_pad0.61193254
86MP0005220_abnormal_exocrine_pancreas0.59944455
87MP0002877_abnormal_melanocyte_morpholog0.59595406
88MP0004264_abnormal_extraembryonic_tissu0.59297618
89MP0002006_tumorigenesis0.59000997
90MP0002089_abnormal_postnatal_growth/wei0.58942452
91MP0000477_abnormal_intestine_morphology0.58478187
92MP0002971_abnormal_brown_adipose0.57008054
93MP0001216_abnormal_epidermal_layer0.55585660
94MP0000604_amyloidosis0.55517435
95MP0005248_abnormal_Harderian_gland0.55323109
96MP0002396_abnormal_hematopoietic_system0.54424774
97MP0001845_abnormal_inflammatory_respons0.53917733
98MP0001765_abnormal_ion_homeostasis0.53543472
99MP0000003_abnormal_adipose_tissue0.53454665
100MP0008872_abnormal_physiological_respon0.53339543
101MP0001835_abnormal_antigen_presentation0.52952984
102MP0002136_abnormal_kidney_physiology0.52644908
103MP0005535_abnormal_body_temperature0.51489318
104MP0005166_decreased_susceptibility_to0.51474626
105MP0003718_maternal_effect0.50905511
106MP0002078_abnormal_glucose_homeostasis0.50623709
107MP0000249_abnormal_blood_vessel0.50314511
108MP0002249_abnormal_larynx_morphology0.48240640
109MP0004272_abnormal_basement_membrane0.48089745
110MP0000467_abnormal_esophagus_morphology0.47822040
111MP0005275_abnormal_skin_tensile0.47119560
112MP0005187_abnormal_penis_morphology0.47007216
113MP0003638_abnormal_response/metabolism_0.46717921
114MP0010030_abnormal_orbit_morphology0.46607141
115MP0003724_increased_susceptibility_to0.46441681
116MP0001851_eye_inflammation0.46368263
117MP0001800_abnormal_humoral_immune0.45503501
118MP0005395_other_phenotype0.43951532
119MP0005377_hearing/vestibular/ear_phenot0.43233363
120MP0003878_abnormal_ear_physiology0.43233363
121MP0001790_abnormal_immune_system0.43065421
122MP0005387_immune_system_phenotype0.43065421
123MP0000538_abnormal_urinary_bladder0.42855693
124MP0005058_abnormal_lysosome_morphology0.41725838
125MP0001984_abnormal_olfaction0.41342891
126MP0006036_abnormal_mitochondrial_physio0.41096047
127MP0008873_increased_physiological_sensi0.40670665
128MP0005164_abnormal_response_to0.40061442
129MP0000579_abnormal_nail_morphology0.40040360
130MP0002060_abnormal_skin_morphology0.39832481
131MP0009115_abnormal_fat_cell0.39047483
132MP0000639_abnormal_adrenal_gland0.38249153
133MP0001853_heart_inflammation0.37252394
134MP0006082_CNS_inflammation0.37111695
135MP0004883_abnormal_blood_vessel0.36922204
136MP0005448_abnormal_energy_balance0.36607722
137MP0001177_atelectasis0.35947452
138MP0002796_impaired_skin_barrier0.35771612
139MP0005464_abnormal_platelet_physiology0.34450656
140MP0002928_abnormal_bile_duct0.33179804
141MP0002098_abnormal_vibrissa_morphology0.32495298
142MP0003953_abnormal_hormone_level0.31816778
143MP0002282_abnormal_trachea_morphology0.31601970
144* MP0000163_abnormal_cartilage_morphology0.31075829
145MP0003136_yellow_coat_color0.30830386
146MP0002233_abnormal_nose_morphology0.30341393
147MP0009780_abnormal_chondrocyte_physiolo0.30038277

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.24033498
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.83855418
3Deep venous thrombosis (HP:0002625)6.74548894
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.44384021
5Prolonged partial thromboplastin time (HP:0003645)6.34088057
6Hypobetalipoproteinemia (HP:0003563)6.20698454
7Xanthomatosis (HP:0000991)5.99609941
8Hyperlipoproteinemia (HP:0010980)5.09727757
9Complement deficiency (HP:0004431)4.84568576
10Hypolipoproteinemia (HP:0010981)4.80357355
11Joint hemorrhage (HP:0005261)4.57163702
12Fat malabsorption (HP:0002630)4.43610685
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41809963
14Abnormality of methionine metabolism (HP:0010901)4.37584965
15Epidermoid cyst (HP:0200040)4.32688193
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.31588034
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.30408723
18Hypoalphalipoproteinemia (HP:0003233)4.30167944
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.28108897
20Hyperammonemia (HP:0001987)4.24422966
21Conjugated hyperbilirubinemia (HP:0002908)4.15345470
22Abnormality of the common coagulation pathway (HP:0010990)4.08480662
23Hyperglycinuria (HP:0003108)3.95493352
24Hyperglycinemia (HP:0002154)3.95279966
25Abnormality of glycine metabolism (HP:0010895)3.78413254
26Abnormality of serine family amino acid metabolism (HP:0010894)3.78413254
27Ketosis (HP:0001946)3.75031248
28Hypoglycemic coma (HP:0001325)3.66293489
29Abnormality of pyrimidine metabolism (HP:0004353)3.65492505
30Abnormality of complement system (HP:0005339)3.63331426
31Abnormality of the intrinsic pathway (HP:0010989)3.50809040
32Steatorrhea (HP:0002570)3.47402058
33Hypercholesterolemia (HP:0003124)3.32210312
34Hyperbilirubinemia (HP:0002904)3.25536548
35Abnormality of fatty-acid metabolism (HP:0004359)3.22579857
36Myocardial infarction (HP:0001658)3.16304092
37Renal cortical cysts (HP:0000803)3.05099506
38Hypochromic microcytic anemia (HP:0004840)2.93500199
39Fair hair (HP:0002286)2.93453162
40Abnormality of nucleobase metabolism (HP:0010932)2.93156452
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91883541
42Hepatocellular carcinoma (HP:0001402)2.86947894
43Delayed CNS myelination (HP:0002188)2.86807135
44Abnormality of serum amino acid levels (HP:0003112)2.85450243
45Vascular calcification (HP:0004934)2.82648237
46Enlarged kidneys (HP:0000105)2.78534904
47Metabolic acidosis (HP:0001942)2.65417891
48Spontaneous abortion (HP:0005268)2.62996115
49Nephritis (HP:0000123)2.61687991
50Hemorrhage of the eye (HP:0011885)2.57911976
51Abnormality of purine metabolism (HP:0004352)2.56988426
52Ketoacidosis (HP:0001993)2.56478922
53Hypophosphatemic rickets (HP:0004912)2.55242832
54Acanthocytosis (HP:0001927)2.50088162
55Systemic lupus erythematosus (HP:0002725)2.47047611
56Cardiovascular calcification (HP:0011915)2.45401352
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44133196
58Dicarboxylic aciduria (HP:0003215)2.44133196
59Lethargy (HP:0001254)2.41281702
60Osteomalacia (HP:0002749)2.40425867
61Proximal tubulopathy (HP:0000114)2.40386727
62Rickets (HP:0002748)2.38251597
63Hydroxyprolinuria (HP:0003080)2.35426230
64Abnormality of proline metabolism (HP:0010907)2.35426230
65Malnutrition (HP:0004395)2.33010481
66Opisthotonus (HP:0002179)2.27282354
67Increased mean platelet volume (HP:0011877)2.25888404
68Hypoglycemic seizures (HP:0002173)2.23256515
69Generalized aminoaciduria (HP:0002909)2.22033938
70Hyperactive renin-angiotensin system (HP:0000841)2.21516922
71Amyloidosis (HP:0011034)2.18724114
72Gout (HP:0001997)2.18057241
73Skin nodule (HP:0200036)2.17861657
74Periodontitis (HP:0000704)2.16374430
75Joint swelling (HP:0001386)2.16054950
76Sensorimotor neuropathy (HP:0007141)2.15010297
77Esophageal varix (HP:0002040)2.12381579
78Abnormal platelet volume (HP:0011876)2.11791138
79Abnormal gallbladder morphology (HP:0012437)2.11547302
80Elevated alkaline phosphatase (HP:0003155)2.10319779
81Mitral stenosis (HP:0001718)2.08571955
82Papillary thyroid carcinoma (HP:0002895)2.06519013
83Cerebral edema (HP:0002181)2.03559225
84Pancreatitis (HP:0001733)2.03515952
85Vitreoretinal degeneration (HP:0000655)2.02753680
86Gingival bleeding (HP:0000225)2.00953829
87Abnormal cartilage morphology (HP:0002763)2.00674077
88Generalized hypopigmentation of hair (HP:0011358)1.99816854
89Cholelithiasis (HP:0001081)1.96803557
90Recurrent gram-negative bacterial infections (HP:0005420)1.95570936
91Menorrhagia (HP:0000132)1.92768150
92Abnormality of alkaline phosphatase activity (HP:0004379)1.91383830
93Vomiting (HP:0002013)1.90866450
94Irritability (HP:0000737)1.90467084
95Glycosuria (HP:0003076)1.89255359
96Abnormality of urine glucose concentration (HP:0011016)1.89255359
97Spastic diplegia (HP:0001264)1.88835059
98Poikilocytosis (HP:0004447)1.88590187
99Cholecystitis (HP:0001082)1.87620592
100Abnormal gallbladder physiology (HP:0012438)1.87620592
101Chronic diarrhea (HP:0002028)1.86730153
102* Flat acetabular roof (HP:0003180)1.86304664
103Thrombophlebitis (HP:0004418)1.86113958
104Abnormal enzyme/coenzyme activity (HP:0012379)1.86043323
105Abdominal distention (HP:0003270)1.85779868
106* Abnormal tarsal ossification (HP:0008369)1.84678537
107Glomerulonephritis (HP:0000099)1.84663157
108Abnormality of vitamin metabolism (HP:0100508)1.83916956
109Confusion (HP:0001289)1.83246411
110Decreased circulating renin level (HP:0003351)1.82970658
111Alkalosis (HP:0001948)1.82741320
112Neonatal onset (HP:0003623)1.82369467
113Abnormality of the gallbladder (HP:0005264)1.82250190
114Brushfield spots (HP:0001088)1.81214787
115Conjunctival telangiectasia (HP:0000524)1.79056050
116Elevated hepatic transaminases (HP:0002910)1.78238705
117Arthropathy (HP:0003040)1.76841471
118Alveolar cell carcinoma (HP:0006519)1.73911944
119Abnormal delivery (HP:0001787)1.73004960
120Thickened calvaria (HP:0002684)1.72599452
121Epistaxis (HP:0000421)1.68852858
122Pulmonary embolism (HP:0002204)1.68548362
123Lower limb hyperreflexia (HP:0002395)1.64501548
124Large earlobe (HP:0009748)1.62283810
125Neonatal short-limb short stature (HP:0008921)1.61579364
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.60737729
127* Abnormality of carpal bone ossification (HP:0006257)1.58610375
128Protuberant abdomen (HP:0001538)1.58081967
129Right ventricular cardiomyopathy (HP:0011663)1.56288984
130Osteolytic defects of the hand bones (HP:0009699)1.56272080
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.56272080
132Mucopolysacchariduria (HP:0008155)1.55371907
133Urinary glycosaminoglycan excretion (HP:0003541)1.55371907
134Coarse hair (HP:0002208)1.53960785
135Abnormality of the gastric mucosa (HP:0004295)1.52016398
136Purpura (HP:0000979)1.51064176
137Submucous cleft hard palate (HP:0000176)1.50455349
138Ileus (HP:0002595)1.47904868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.58769172
2SIK13.48095531
3FRK3.38676382
4FGFR43.31232349
5INSRR3.02758437
6ACVR1B2.88759503
7CDK122.78150058
8ERBB42.71754442
9MAP3K32.70231120
10ERN12.58899216
11MAP2K32.36861846
12MST1R2.32202905
13PRPF4B2.14055400
14LATS12.13607495
15NUAK12.09300223
16MAP2K41.96850795
17PBK1.90286205
18PIK3CA1.89384371
19MAP3K21.83430612
20TAOK31.83032599
21STK241.79607581
22MAP3K141.74732881
23CDK91.72724443
24EIF2AK31.69608024
25STK38L1.65259616
26NEK91.62786127
27MAPK151.62612292
28RIPK11.53620888
29TRPM71.53096477
30STK391.49272100
31MAPK111.46981293
32MAP3K131.45825794
33ZAK1.40097427
34AKT31.34972731
35MAPK71.34910848
36TAOK21.34151068
37KSR21.34095178
38SGK21.33030742
39IRAK31.24307989
40MAP2K61.23578757
41BRSK21.23079607
42BRD41.21730044
43EPHB21.21471686
44ERBB21.19758329
45SGK31.19128726
46JAK31.18611060
47PIK3CG1.18251777
48PINK11.16372478
49MAP3K101.14152145
50PDGFRA1.13942783
51CDK61.13118215
52ABL21.12859081
53MAP3K61.04896177
54TYK21.02856231
55PKN20.98296439
56CSF1R0.97879309
57MAPK120.97124393
58MAPK40.96906191
59PRKAA20.95275352
60MAP3K120.93610332
61MELK0.93244658
62RAF10.92584058
63NEK60.88195974
64EPHB10.85610698
65FGFR20.84777775
66GRK60.83935676
67SGK4940.82882889
68SGK2230.82882889
69MET0.80564219
70WNK40.79135118
71STK380.78460057
72PTK60.78201457
73EPHA30.77896309
74PDK10.76765156
75JAK20.76642033
76NLK0.75878474
77GRK10.74984600
78GSK3A0.74390225
79MAP2K20.73524707
80JAK10.72908593
81FLT30.71076041
82MAP3K50.70666393
83PRKG20.69490833
84WNK10.68678556
85TIE10.68340141
86PDPK10.67938428
87PDK20.66373753
88KSR10.64920373
89MAP3K70.64588637
90LMTK20.64454183
91RET0.64428463
92IKBKE0.63242641
93TXK0.63032517
94MST40.62480305
95ZAP700.61954161
96CSNK1G10.60761480
97SIK30.60316043
98FER0.59799752
99IGF1R0.59749162
100CSNK1A1L0.58951828
101PRKCQ0.58312578
102STK30.57876996
103MAP3K10.56995484
104CDK80.56462851
105MAP3K110.56018460
106PDGFRB0.55419748
107FGFR30.55118921
108DAPK20.53135751
109KDR0.52267325
110ERBB30.51912370
111CSK0.51728565
112MAP4K10.51348925
113ICK0.51136301
114TRIB30.50398595
115BCR0.50031964
116EPHA20.49244577
117CAMK2G0.49119345
118TBK10.48999227
119PRKACG0.47768319
120ADRBK20.47243171
121MAPK30.45507985
122CASK0.45413924
123TNK20.44977328
124PTK20.44609440
125PRKAA10.44421847
126MYLK0.42328170
127PRKCZ0.41872507
128PIM10.41450158
129MTOR0.41354366
130CDC42BPA0.41010618
131DDR20.40384857
132IKBKB0.39685348
133MATK0.39485329
134BTK0.38724936
135CAMKK20.35988871
136KIT0.35936543
137MAP2K10.35753478
138RPS6KB10.35590329
139TGFBR20.35341052
140CHUK0.34276071
141IRAK10.33932141
142PRKCA0.33797478
143BLK0.33549609
144ABL10.32899465
145CDK40.30719777
146ITK0.30161142
147BMPR20.29538433

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.20750103
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.85810631
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.02408245
4Nitrogen metabolism_Homo sapiens_hsa009103.00691215
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67366978
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.66674252
7Arginine biosynthesis_Homo sapiens_hsa002202.66418941
8Tryptophan metabolism_Homo sapiens_hsa003802.57168687
9Complement and coagulation cascades_Homo sapiens_hsa046102.53475368
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.47171058
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.43998057
12Chemical carcinogenesis_Homo sapiens_hsa052042.40752090
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36501200
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36279335
15Fatty acid degradation_Homo sapiens_hsa000712.27875084
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21015444
17Butanoate metabolism_Homo sapiens_hsa006502.19867901
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18912810
19Sulfur metabolism_Homo sapiens_hsa009202.05502626
20Peroxisome_Homo sapiens_hsa041462.04817059
21Caffeine metabolism_Homo sapiens_hsa002322.02724961
22Retinol metabolism_Homo sapiens_hsa008301.97350802
23Histidine metabolism_Homo sapiens_hsa003401.96277907
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.89711143
25Propanoate metabolism_Homo sapiens_hsa006401.78146650
26beta-Alanine metabolism_Homo sapiens_hsa004101.76606381
27PPAR signaling pathway_Homo sapiens_hsa033201.74945014
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73760707
29Starch and sucrose metabolism_Homo sapiens_hsa005001.64054603
30Fatty acid metabolism_Homo sapiens_hsa012121.59839249
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55895826
32Bile secretion_Homo sapiens_hsa049761.51571488
33Staphylococcus aureus infection_Homo sapiens_hsa051501.50868963
34Selenocompound metabolism_Homo sapiens_hsa004501.49295753
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48710206
36Phenylalanine metabolism_Homo sapiens_hsa003601.46742704
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44541767
38ABC transporters_Homo sapiens_hsa020101.41081637
39Steroid biosynthesis_Homo sapiens_hsa001001.35738258
40Tyrosine metabolism_Homo sapiens_hsa003501.32678571
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26624241
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24884448
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.19511129
44Folate biosynthesis_Homo sapiens_hsa007901.18305880
45Sulfur relay system_Homo sapiens_hsa041221.17236256
46Fatty acid elongation_Homo sapiens_hsa000621.15571005
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11785661
48Pyruvate metabolism_Homo sapiens_hsa006201.10270017
49Fat digestion and absorption_Homo sapiens_hsa049751.07535656
50Vitamin digestion and absorption_Homo sapiens_hsa049771.06260909
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05276808
52Glutathione metabolism_Homo sapiens_hsa004801.01103334
53Arginine and proline metabolism_Homo sapiens_hsa003300.98665754
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.95744474
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.95240117
56Biosynthesis of amino acids_Homo sapiens_hsa012300.86295739
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83946353
58Carbon metabolism_Homo sapiens_hsa012000.81793346
59Lysine degradation_Homo sapiens_hsa003100.80215670
60Vitamin B6 metabolism_Homo sapiens_hsa007500.78784697
61One carbon pool by folate_Homo sapiens_hsa006700.76761398
62Other glycan degradation_Homo sapiens_hsa005110.73723653
63Glycerolipid metabolism_Homo sapiens_hsa005610.61854432
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61718959
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53844747
66Sphingolipid metabolism_Homo sapiens_hsa006000.51296743
67Metabolic pathways_Homo sapiens_hsa011000.48652917
68Galactose metabolism_Homo sapiens_hsa000520.48167176
69Fatty acid biosynthesis_Homo sapiens_hsa000610.43451618
70Pentose phosphate pathway_Homo sapiens_hsa000300.37603454
71Prion diseases_Homo sapiens_hsa050200.28277686
72Linoleic acid metabolism_Homo sapiens_hsa005910.26495392
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23636714
74Fructose and mannose metabolism_Homo sapiens_hsa000510.21989521
75N-Glycan biosynthesis_Homo sapiens_hsa005100.20363975
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20236488
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17309933
78Thyroid cancer_Homo sapiens_hsa052160.16617048
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15763924
80Insulin resistance_Homo sapiens_hsa049310.15536937
81Dorso-ventral axis formation_Homo sapiens_hsa043200.12032028
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10097691
83Ether lipid metabolism_Homo sapiens_hsa005650.09846231
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.09773463
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09559971
86Prostate cancer_Homo sapiens_hsa052150.09309075
87TGF-beta signaling pathway_Homo sapiens_hsa043500.09215861
88Amoebiasis_Homo sapiens_hsa051460.08482344
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.07714970
90Mineral absorption_Homo sapiens_hsa049780.07714063
91Small cell lung cancer_Homo sapiens_hsa052220.07691631
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07612466
93FoxO signaling pathway_Homo sapiens_hsa040680.07537029
94Inositol phosphate metabolism_Homo sapiens_hsa005620.07341242
95Pancreatic secretion_Homo sapiens_hsa049720.06930931
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.05839515
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.04862896
98Arachidonic acid metabolism_Homo sapiens_hsa005900.02982458
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.02783836
100Ovarian steroidogenesis_Homo sapiens_hsa049130.01323418
101ECM-receptor interaction_Homo sapiens_hsa04512-0.2182785
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.2142230
103Pertussis_Homo sapiens_hsa05133-0.2104087
104Bladder cancer_Homo sapiens_hsa05219-0.2000357
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1979719
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1893451
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1734839
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1544658
109AMPK signaling pathway_Homo sapiens_hsa04152-0.1323431
110Malaria_Homo sapiens_hsa05144-0.1202668
111Renin-angiotensin system_Homo sapiens_hsa04614-0.1124979
112Hepatitis C_Homo sapiens_hsa05160-0.0840610
113Circadian rhythm_Homo sapiens_hsa04710-0.0739216
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0636854
115Glucagon signaling pathway_Homo sapiens_hsa04922-0.0589271
116Protein digestion and absorption_Homo sapiens_hsa04974-0.0428290
117Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0163433
118African trypanosomiasis_Homo sapiens_hsa05143-0.0047434

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