SLC35A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.23806226
2DNA strand elongation involved in DNA replication (GO:0006271)5.10553174
3ribosomal small subunit assembly (GO:0000028)4.94175208
4telomere maintenance via semi-conservative replication (GO:0032201)4.86494616
5DNA strand elongation (GO:0022616)4.85528106
6IMP biosynthetic process (GO:0006188)4.25980252
7DNA unwinding involved in DNA replication (GO:0006268)4.23232421
8telomere maintenance via recombination (GO:0000722)4.22696778
9DNA replication initiation (GO:0006270)4.11804261
10NADH metabolic process (GO:0006734)4.06377262
11nucleobase biosynthetic process (GO:0046112)3.92962262
12maturation of SSU-rRNA (GO:0030490)3.89583273
13peptidyl-arginine omega-N-methylation (GO:0035247)3.87570414
14formation of translation preinitiation complex (GO:0001731)3.86025157
15mitotic recombination (GO:0006312)3.85498928
16IMP metabolic process (GO:0046040)3.85142838
17telomere maintenance via telomere lengthening (GO:0010833)3.75392156
18proline biosynthetic process (GO:0006561)3.69463879
19protein localization to kinetochore (GO:0034501)3.60384773
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.56820104
21viral transcription (GO:0019083)3.55639196
22DNA replication checkpoint (GO:0000076)3.50007658
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.49079854
24establishment of viral latency (GO:0019043)3.48093447
25translational termination (GO:0006415)3.48048080
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47152071
27purine nucleobase biosynthetic process (GO:0009113)3.44341265
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43723431
29pentose-phosphate shunt (GO:0006098)3.42171693
30folic acid-containing compound biosynthetic process (GO:0009396)3.41805429
31tricarboxylic acid cycle (GO:0006099)3.40365297
32translational elongation (GO:0006414)3.40070942
33mitotic nuclear envelope disassembly (GO:0007077)3.35093861
34protein maturation by protein folding (GO:0022417)3.34106835
35protein targeting to ER (GO:0045047)3.30821861
36cotranslational protein targeting to membrane (GO:0006613)3.30283635
37retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.29335163
38nuclear envelope reassembly (GO:0031468)3.27545806
39mitotic nuclear envelope reassembly (GO:0007084)3.27545806
40NIK/NF-kappaB signaling (GO:0038061)3.24415012
41regulation of cellular amino acid metabolic process (GO:0006521)3.19162980
42establishment of integrated proviral latency (GO:0075713)3.16277829
43CENP-A containing nucleosome assembly (GO:0034080)3.14409575
44pseudouridine synthesis (GO:0001522)3.13858665
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13625524
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13625524
47protein localization to endoplasmic reticulum (GO:0070972)3.12371105
48ribosome biogenesis (GO:0042254)3.12338768
49translational initiation (GO:0006413)3.12225142
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12117685
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10112980
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10112980
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10112980
54membrane disassembly (GO:0030397)3.08063995
55nuclear envelope disassembly (GO:0051081)3.08063995
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.08006664
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08006664
58protein localization to chromosome, centromeric region (GO:0071459)3.06688131
59NADPH regeneration (GO:0006740)3.05964346
60ribosomal small subunit biogenesis (GO:0042274)3.03456756
61ribonucleoprotein complex biogenesis (GO:0022613)3.01519850
62histone arginine methylation (GO:0034969)3.00936979
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.00251336
64chromatin remodeling at centromere (GO:0031055)2.97373172
65GDP-mannose metabolic process (GO:0019673)2.96135181
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95283329
67tRNA aminoacylation for protein translation (GO:0006418)2.94853563
68proteasome assembly (GO:0043248)2.94848844
69Golgi transport vesicle coating (GO:0048200)2.94185567
70COPI coating of Golgi vesicle (GO:0048205)2.94185567
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93337138
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90668171
73DNA replication-independent nucleosome assembly (GO:0006336)2.87447850
74DNA replication-independent nucleosome organization (GO:0034724)2.87447850
75peptidyl-arginine methylation (GO:0018216)2.87160446
76peptidyl-arginine N-methylation (GO:0035246)2.87160446
77rRNA processing (GO:0006364)2.87086545
78ribosomal large subunit biogenesis (GO:0042273)2.86608100
79telomere maintenance (GO:0000723)2.85841748
80telomere organization (GO:0032200)2.84984609
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84928795
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84928795
83mitotic metaphase plate congression (GO:0007080)2.82806292
84amino acid activation (GO:0043038)2.80080213
85tRNA aminoacylation (GO:0043039)2.80080213
86spliceosomal snRNP assembly (GO:0000387)2.80003788
87attachment of spindle microtubules to kinetochore (GO:0008608)2.78752409
88viral life cycle (GO:0019058)2.78613258
89negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.78427134
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77822844
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77137408
92gluconeogenesis (GO:0006094)2.77072497
93transcription-coupled nucleotide-excision repair (GO:0006283)2.76716781
94glucose catabolic process (GO:0006007)2.75175799
95chaperone mediated protein folding requiring cofactor (GO:0051085)2.75038338
96rRNA metabolic process (GO:0016072)2.74689640
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73687105
98translation (GO:0006412)2.72303643
99tricarboxylic acid metabolic process (GO:0072350)2.72246513
100cellular response to interleukin-4 (GO:0071353)2.70537993
101monosaccharide biosynthetic process (GO:0046364)2.70516729
102cellular protein complex disassembly (GO:0043624)2.70447763
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70280407
104negative regulation of RNA splicing (GO:0033119)2.69913720
105negative regulation of ligase activity (GO:0051352)2.69803799
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69803799
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69583494
108oxaloacetate metabolic process (GO:0006107)2.68102090
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67965866
110pentose metabolic process (GO:0019321)2.67435013
111G1/S transition of mitotic cell cycle (GO:0000082)2.66594783
112cell cycle G1/S phase transition (GO:0044843)2.66594783
113negative regulation of DNA-templated transcription, elongation (GO:0032785)2.65704930
114positive regulation of ligase activity (GO:0051351)2.63218670
1153-UTR-mediated mRNA stabilization (GO:0070935)2.62560537
116glycolytic process (GO:0006096)2.62469101
117regulation of protein heterodimerization activity (GO:0043497)2.62429927
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.62026126
119base-excision repair (GO:0006284)2.61821979
120antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.61317772
121regulation of translational termination (GO:0006449)2.61259292
122ribosome assembly (GO:0042255)2.59180380
123DNA duplex unwinding (GO:0032508)2.59145751
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58416943
125purine-containing compound salvage (GO:0043101)2.58409769
126response to interferon-beta (GO:0035456)2.58075157
127negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.57954827
128viral mRNA export from host cell nucleus (GO:0046784)2.57451776
129hexose biosynthetic process (GO:0019319)2.57449773
130translesion synthesis (GO:0019985)2.56877276
131DNA geometric change (GO:0032392)2.56864480
132branched-chain amino acid catabolic process (GO:0009083)2.56091198
133negative regulation of phagocytosis (GO:0050765)2.55440690
134DNA replication-dependent nucleosome organization (GO:0034723)2.53325805
135DNA replication-dependent nucleosome assembly (GO:0006335)2.53325805
136kinetochore organization (GO:0051383)2.53255254
137regulation of spindle organization (GO:0090224)2.52607171
138T cell apoptotic process (GO:0070231)2.52260364
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.52123277
140positive regulation of cell cycle arrest (GO:0071158)2.51387090
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51326808
142protein complex disassembly (GO:0043241)2.51010111
143postreplication repair (GO:0006301)2.50247952
144histone H2A acetylation (GO:0043968)2.49515074
145pteridine-containing compound biosynthetic process (GO:0042559)2.49246388
146rRNA modification (GO:0000154)2.48764954
147snRNA processing (GO:0016180)2.48664505
148amyloid precursor protein catabolic process (GO:0042987)2.47258295
149endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46896488
150DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46592160
151pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.46353550
152regulation of ubiquitin-protein transferase activity (GO:0051438)2.46306343
153metaphase plate congression (GO:0051310)2.46212062
154RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.45748497
155mRNA splicing, via spliceosome (GO:0000398)2.45748497
156cellular response to interferon-beta (GO:0035458)2.44110662
157negative regulation of B cell apoptotic process (GO:0002903)2.42965791
158positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.42430514
159regulation of ligase activity (GO:0051340)2.41420850
160antigen processing and presentation of endogenous antigen (GO:0019883)2.41248539
161protein deneddylation (GO:0000338)2.40684970
162ncRNA 3-end processing (GO:0043628)2.38365242
163virion assembly (GO:0019068)2.37900360
164membrane protein intracellular domain proteolysis (GO:0031293)2.37818975
165iron-sulfur cluster assembly (GO:0016226)2.36683831
166metallo-sulfur cluster assembly (GO:0031163)2.36683831
167L-serine metabolic process (GO:0006563)2.36277353
168DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.34860156
169positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33241857
170pinocytosis (GO:0006907)2.31531372
171response to interleukin-4 (GO:0070670)2.30611269
172folic acid metabolic process (GO:0046655)2.29599409
173cullin deneddylation (GO:0010388)2.29485429
174oxidative phosphorylation (GO:0006119)2.26780683
175negative regulation of protein ubiquitination (GO:0031397)2.26617526
176pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.22526455
177cellular response to type I interferon (GO:0071357)2.22503806
178type I interferon signaling pathway (GO:0060337)2.22503806
179regulation of mitochondrial membrane potential (GO:0051881)2.22473634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.38277630
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10305960
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.69222764
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96296073
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77055489
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76589908
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.75737472
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.74740139
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69943501
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.65027850
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64886265
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.56527946
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49666464
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40950622
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40909973
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34750903
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31058476
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29886882
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29209178
20MYC_22102868_ChIP-Seq_BL_Human2.21374592
21XRN2_22483619_ChIP-Seq_HELA_Human2.15535394
22VDR_23849224_ChIP-Seq_CD4+_Human2.07632743
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.06083644
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05116985
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02418698
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.00249834
27CIITA_25753668_ChIP-Seq_RAJI_Human1.90928513
28FOXP3_21729870_ChIP-Seq_TREG_Human1.89967886
29GABP_19822575_ChIP-Seq_HepG2_Human1.85588653
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83850655
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82858462
32DCP1A_22483619_ChIP-Seq_HELA_Human1.78947183
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75374307
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.71850360
35VDR_21846776_ChIP-Seq_THP-1_Human1.71540891
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70740914
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68941834
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.68596183
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67865907
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64643782
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64591943
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64514086
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.63657881
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63252597
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62876504
46AR_21909140_ChIP-Seq_LNCAP_Human1.62750362
47LXR_22292898_ChIP-Seq_THP-1_Human1.60955438
48TTF2_22483619_ChIP-Seq_HELA_Human1.59863865
49* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59466874
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56420149
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52789248
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51739883
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50363525
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48868723
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48558680
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.46954812
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44690560
58SPI1_23547873_ChIP-Seq_NB4_Human1.43486555
59ZNF263_19887448_ChIP-Seq_K562_Human1.43462709
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42995714
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.40680231
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36599134
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33955517
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32431281
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.31732526
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.31715683
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31266536
68KDM5A_27292631_Chip-Seq_BREAST_Human1.29722278
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28678708
70SCL_19346495_ChIP-Seq_HPC-7_Human1.28104454
71* ELK1_19687146_ChIP-ChIP_HELA_Human1.28056327
72* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27957806
73RACK7_27058665_Chip-Seq_MCF-7_Human1.27682595
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26708702
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25933328
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24838043
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24775730
78* TFEB_21752829_ChIP-Seq_HELA_Human1.24674493
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22247901
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.19203556
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18890801
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18833172
83MAF_26560356_Chip-Seq_TH2_Human1.16381586
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14087975
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13689664
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12220942
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11935500
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11186837
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10301155
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10246587
91BCL6_27268052_Chip-Seq_Bcells_Human1.10013125
92P68_20966046_ChIP-Seq_HELA_Human1.09530787
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08882674
94MAF_26560356_Chip-Seq_TH1_Human1.08059899
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07947965
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07824679
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07702851
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07231047
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07222126
100MYB_26560356_Chip-Seq_TH2_Human1.06531173
101GATA1_22025678_ChIP-Seq_K562_Human1.05893318
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05546515
103UTX_26944678_Chip-Seq_JUKART_Human1.05256291
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03617668
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.03173924
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02732156
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02253383
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01588212
109CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01564296
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.01011583
111CTCF_26484167_Chip-Seq_Bcells_Mouse1.00824290
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.00069930
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00035912
114MYB_26560356_Chip-Seq_TH1_Human0.97998797
115VDR_24763502_ChIP-Seq_THP-1_Human0.97572836
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96824848
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94768353
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93748416
119* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93321968
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92820543
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90530052
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90131022
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87665408
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86666623
125GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86588904
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86412618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.32698547
2MP0005451_abnormal_body_composition3.84853541
3MP0002396_abnormal_hematopoietic_system3.68617514
4MP0010094_abnormal_chromosome_stability3.36120502
5MP0004957_abnormal_blastocyst_morpholog3.24061027
6MP0003111_abnormal_nucleus_morphology3.16812368
7MP0003077_abnormal_cell_cycle3.02764641
8MP0006054_spinal_hemorrhage2.96035233
9MP0008057_abnormal_DNA_replication2.76573903
10MP0008007_abnormal_cellular_replicative2.69370280
11MP0008260_abnormal_autophagy2.47339088
12MP0008058_abnormal_DNA_repair2.38361580
13MP0000490_abnormal_crypts_of2.21805252
14MP0003763_abnormal_thymus_physiology2.19245618
15MP0004808_abnormal_hematopoietic_stem2.16067391
16MP0009333_abnormal_splenocyte_physiolog2.10533171
17MP0000751_myopathy2.08408786
18MP0001545_abnormal_hematopoietic_system2.06114248
19MP0005397_hematopoietic_system_phenotyp2.06114248
20MP0004233_abnormal_muscle_weight2.01499830
21MP0001835_abnormal_antigen_presentation2.01253138
22MP0010352_gastrointestinal_tract_polyps1.97728334
23MP0003806_abnormal_nucleotide_metabolis1.92020703
24MP0004858_abnormal_nervous_system1.90224063
25MP0002398_abnormal_bone_marrow1.83296865
26MP0009840_abnormal_foam_cell1.73193980
27MP0005671_abnormal_response_to1.72991585
28MP0008932_abnormal_embryonic_tissue1.66579378
29MP0002722_abnormal_immune_system1.59117307
30MP0000350_abnormal_cell_proliferation1.58502756
31MP0000689_abnormal_spleen_morphology1.58248763
32MP0000685_abnormal_immune_system1.55321893
33MP0009785_altered_susceptibility_to1.53141502
34MP0003303_peritoneal_inflammation1.52746081
35MP0000858_altered_metastatic_potential1.51533294
36MP0001730_embryonic_growth_arrest1.51507762
37MP0002019_abnormal_tumor_incidence1.50997252
38MP0001853_heart_inflammation1.49326837
39MP0000703_abnormal_thymus_morphology1.47849368
40MP0002429_abnormal_blood_cell1.46148497
41MP0003436_decreased_susceptibility_to1.45640765
42MP0002420_abnormal_adaptive_immunity1.42934835
43MP0001819_abnormal_immune_cell1.40242692
44MP0000716_abnormal_immune_system1.39934245
45MP0001800_abnormal_humoral_immune1.39817571
46MP0002452_abnormal_antigen_presenting1.38391142
47MP0004147_increased_porphyrin_level1.37246675
48MP0000313_abnormal_cell_death1.36720217
49MP0003123_paternal_imprinting1.36629641
50MP0005330_cardiomyopathy1.36005159
51MP0005025_abnormal_response_to1.35026242
52MP0005000_abnormal_immune_tolerance1.30131875
53MP0002254_reproductive_system_inflammat1.27577547
54MP0000747_muscle_weakness1.25285416
55MP0000465_gastrointestinal_hemorrhage1.25115023
56MP0008789_abnormal_olfactory_epithelium1.25111121
57MP0002723_abnormal_immune_serum1.24556885
58MP0005501_abnormal_skin_physiology1.24179630
59MP0010155_abnormal_intestine_physiology1.24057024
60MP0005670_abnormal_white_adipose1.23279098
61MP0002877_abnormal_melanocyte_morpholog1.23160124
62MP0002166_altered_tumor_susceptibility1.22853557
63MP0000015_abnormal_ear_pigmentation1.21463483
64MP0005464_abnormal_platelet_physiology1.21381184
65MP0010307_abnormal_tumor_latency1.21107757
66MP0002405_respiratory_system_inflammati1.20917803
67MP0003191_abnormal_cellular_cholesterol1.20563427
68MP0003186_abnormal_redox_activity1.19610327
69MP0003786_premature_aging1.16531349
70MP0002080_prenatal_lethality1.16248954
71MP0001727_abnormal_embryo_implantation1.16185959
72MP0000749_muscle_degeneration1.15310518
73MP0003656_abnormal_erythrocyte_physiolo1.14813486
74MP0003075_altered_response_to1.13697281
75MP0001873_stomach_inflammation1.12580172
76MP0001697_abnormal_embryo_size1.12345252
77MP0002419_abnormal_innate_immunity1.11549495
78MP0002796_impaired_skin_barrier1.07690076
79MP0003866_abnormal_defecation1.06293856
80MP0006035_abnormal_mitochondrial_morpho1.05133215
81MP0009278_abnormal_bone_marrow1.03931465
82MP0008469_abnormal_protein_level1.02671954
83MP0005387_immune_system_phenotype1.00129451
84MP0001790_abnormal_immune_system1.00129451
85MP0003984_embryonic_growth_retardation0.99926518
86MP0001346_abnormal_lacrimal_gland0.99764558
87MP0009764_decreased_sensitivity_to0.98806097
88MP0005023_abnormal_wound_healing0.98518306
89MP0005380_embryogenesis_phenotype0.98145993
90MP0001672_abnormal_embryogenesis/_devel0.98145993
91MP0002148_abnormal_hypersensitivity_rea0.97873805
92MP0000759_abnormal_skeletal_muscle0.97588601
93MP0002088_abnormal_embryonic_growth/wei0.95111051
94MP0005319_abnormal_enzyme/_coenzyme0.94752539
95MP0006082_CNS_inflammation0.93625861
96MP0003566_abnormal_cell_adhesion0.93597362
97MP0002006_tumorigenesis0.93110296
98MP0005075_abnormal_melanosome_morpholog0.92915230
99MP0005165_increased_susceptibility_to0.91929605
100MP0003221_abnormal_cardiomyocyte_apopto0.91542964
101MP0001845_abnormal_inflammatory_respons0.91326963
102MP0003646_muscle_fatigue0.90283419
103MP0002933_joint_inflammation0.89891768
104MP0002132_abnormal_respiratory_system0.88422337
105MP0001348_abnormal_lacrimal_gland0.88399517
106MP0000343_altered_response_to0.86834757
107MP0003567_abnormal_fetal_cardiomyocyte0.86224610
108MP0004782_abnormal_surfactant_physiolog0.84795136
109MP0001849_ear_inflammation0.84396661
110MP0003279_aneurysm0.82288682
111MP0000477_abnormal_intestine_morphology0.82132498
112MP0001216_abnormal_epidermal_layer0.82089750
113MP0000358_abnormal_cell_content/0.81419925
114MP0002095_abnormal_skin_pigmentation0.80638912
115MP0003172_abnormal_lysosome_physiology0.80436630
116MP0002086_abnormal_extraembryonic_tissu0.80337257
117MP0001533_abnormal_skeleton_physiology0.79993121
118MP0004947_skin_inflammation0.79119309
119MP0003724_increased_susceptibility_to0.78940772
120MP0003300_gastrointestinal_ulcer0.78670602
121MP0006036_abnormal_mitochondrial_physio0.77329932
122MP0003943_abnormal_hepatobiliary_system0.76280411
123MP0008877_abnormal_DNA_methylation0.74780845
124MP0002089_abnormal_postnatal_growth/wei0.74489444
125MP0005058_abnormal_lysosome_morphology0.72842978
126MP0004197_abnormal_fetal_growth/weight/0.72622599
127MP0001243_abnormal_dermal_layer0.72321915
128MP0001915_intracranial_hemorrhage0.72270221
129MP0002085_abnormal_embryonic_tissue0.72134069
130MP0005384_cellular_phenotype0.70640486
131MP0005621_abnormal_cell_physiology0.69960786
132MP0008438_abnormal_cutaneous_collagen0.67301697
133MP0010030_abnormal_orbit_morphology0.66398293
134MP0000750_abnormal_muscle_regeneration0.62886453
135MP0003448_altered_tumor_morphology0.60449262

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.40092521
2Cholecystitis (HP:0001082)4.35495968
3Abnormal gallbladder physiology (HP:0012438)4.35495968
4Abnormality of cells of the erythroid lineage (HP:0012130)4.12780462
5Aplastic anemia (HP:0001915)4.12514254
6Thrombocytosis (HP:0001894)4.02667456
7Reticulocytopenia (HP:0001896)3.71085722
8Ragged-red muscle fibers (HP:0003200)3.64652668
9Abnormality of glycolysis (HP:0004366)3.50721136
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.34853692
11IgM deficiency (HP:0002850)3.33200403
12Myopathic facies (HP:0002058)3.28330893
13Rhabdomyolysis (HP:0003201)3.18741985
14Microvesicular hepatic steatosis (HP:0001414)3.14192781
15Increased serum pyruvate (HP:0003542)3.13127556
16Oral leukoplakia (HP:0002745)3.03677578
17Birth length less than 3rd percentile (HP:0003561)2.94852406
18Petechiae (HP:0000967)2.93280781
19Elevated erythrocyte sedimentation rate (HP:0003565)2.82981858
20Hypertensive crisis (HP:0100735)2.82793261
21Degeneration of anterior horn cells (HP:0002398)2.76702258
22Abnormality of the anterior horn cell (HP:0006802)2.76702258
23Selective tooth agenesis (HP:0001592)2.75103137
24Abnormality of the distal phalanges of the toes (HP:0010182)2.74208401
25Type I transferrin isoform profile (HP:0003642)2.73967471
26Cholelithiasis (HP:0001081)2.70573275
27Fatigue (HP:0012378)2.69662039
28Progressive muscle weakness (HP:0003323)2.63810241
2911 pairs of ribs (HP:0000878)2.60069978
30Increased IgM level (HP:0003496)2.54090447
31Increased connective tissue (HP:0009025)2.51352387
32Exercise-induced myalgia (HP:0003738)2.49092951
33Agnosia (HP:0010524)2.48516571
34Distal lower limb muscle weakness (HP:0009053)2.47279575
35Microretrognathia (HP:0000308)2.46617752
36Rough bone trabeculation (HP:0100670)2.41342424
37Abnormal gallbladder morphology (HP:0012437)2.38455004
38Eczematoid dermatitis (HP:0000976)2.36415616
39Myelodysplasia (HP:0002863)2.35301645
40Long palpebral fissure (HP:0000637)2.34034363
41Pallor (HP:0000980)2.33807688
42Poikiloderma (HP:0001029)2.33761705
43Abnormality of B cell number (HP:0010975)2.33552699
44B lymphocytopenia (HP:0010976)2.33552699
45Hepatosplenomegaly (HP:0001433)2.33256556
46Colon cancer (HP:0003003)2.32502467
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.32132921
48Chronic otitis media (HP:0000389)2.31318603
49Abnormality of the gallbladder (HP:0005264)2.30137846
50Abnormality of glycolipid metabolism (HP:0010969)2.28587897
51Abnormality of liposaccharide metabolism (HP:0010968)2.28587897
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.28587897
53Entropion (HP:0000621)2.26510859
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24871723
55Abnormal protein N-linked glycosylation (HP:0012347)2.24871723
56Abnormal protein glycosylation (HP:0012346)2.24871723
57Abnormal glycosylation (HP:0012345)2.24871723
58Abnormality of T cell physiology (HP:0011840)2.24730426
59Increased IgE level (HP:0003212)2.23716733
60Macrocytic anemia (HP:0001972)2.22458785
61Hypokinesia (HP:0002375)2.20269326
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17806870
63Cervical subluxation (HP:0003308)2.16746097
64Lymphoma (HP:0002665)2.15713346
65J-shaped sella turcica (HP:0002680)2.14815222
66Reduced antithrombin III activity (HP:0001976)2.14495666
67Abnormality of the calcaneus (HP:0008364)2.12920537
68Recurrent viral infections (HP:0004429)2.12699891
69Myoglobinuria (HP:0002913)2.11866133
70Prolonged neonatal jaundice (HP:0006579)2.10661383
71Bone marrow hypocellularity (HP:0005528)2.10506378
72Pancytopenia (HP:0001876)2.10457675
73Muscle fiber atrophy (HP:0100295)2.10297086
74Dicarboxylic aciduria (HP:0003215)2.09369903
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09369903
76Progressive neurologic deterioration (HP:0002344)2.09275169
77Abnormality of the umbilical cord (HP:0010881)2.09192852
78Abnormal mitochondria in muscle tissue (HP:0008316)2.08512680
79Nemaline bodies (HP:0003798)2.08393682
80Exercise intolerance (HP:0003546)2.08355512
81Cerebral hypomyelination (HP:0006808)2.07045174
82Lactic acidosis (HP:0003128)2.06469480
83Abnormality of T cells (HP:0002843)2.06010591
84Axonal loss (HP:0003447)2.05261084
85Carpal bone hypoplasia (HP:0001498)2.05107241
86Hyperacusis (HP:0010780)2.04097711
87Recurrent abscess formation (HP:0002722)2.02757019
88Patellar aplasia (HP:0006443)2.01637029
89Trismus (HP:0000211)2.01608409
90Basal cell carcinoma (HP:0002671)2.01034363
91Chromsome breakage (HP:0040012)1.99056748
92Multiple enchondromatosis (HP:0005701)1.99033941
93Testicular atrophy (HP:0000029)1.97710165
94Recurrent bronchitis (HP:0002837)1.97386972
95Nonimmune hydrops fetalis (HP:0001790)1.96878845
96Agammaglobulinemia (HP:0004432)1.96732977
97Distal upper limb amyotrophy (HP:0007149)1.95264153
98Upper limb amyotrophy (HP:0009129)1.95264153
99Reticulocytosis (HP:0001923)1.95230337
100Increased muscle lipid content (HP:0009058)1.95187057
101Premature graying of hair (HP:0002216)1.95031811
102Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93441464
103Myositis (HP:0100614)1.92919154
104Muscle fiber inclusion bodies (HP:0100299)1.92589512
105Abnormality of the preputium (HP:0100587)1.92331147
106Cerebral palsy (HP:0100021)1.91564236
107Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91063282
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91063282
109Neck muscle weakness (HP:0000467)1.90533074
110Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89990372
111Abnormality of skeletal muscle fiber size (HP:0012084)1.88781028
112Amaurosis fugax (HP:0100576)1.88313159
113Type 2 muscle fiber atrophy (HP:0003554)1.88257881
114Aplasia/Hypoplasia of the patella (HP:0006498)1.87795689
115Hepatic necrosis (HP:0002605)1.86046908
116Calcaneovalgus deformity (HP:0001848)1.84689594
117Neoplasm of the pancreas (HP:0002894)1.83715245
118Slender long bone (HP:0003100)1.83707949
119Medulloblastoma (HP:0002885)1.83317406
120Athetosis (HP:0002305)1.83245140
121Distal lower limb amyotrophy (HP:0008944)1.83153800
122Abnormality of chromosome stability (HP:0003220)1.82906569
123Lymphopenia (HP:0001888)1.81906124
124Abnormality of cells of the lymphoid lineage (HP:0012140)1.81336316
125Poor head control (HP:0002421)1.81188485
126Meckel diverticulum (HP:0002245)1.80796367
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80061296
128Absent epiphyses (HP:0010577)1.80061296
129Loss of speech (HP:0002371)1.79437776
130Hepatocellular necrosis (HP:0001404)1.78204831
131IgG deficiency (HP:0004315)1.76622369
132Acute necrotizing encephalopathy (HP:0006965)1.76532442
133Breast hypoplasia (HP:0003187)1.75710232
134Hand muscle atrophy (HP:0009130)1.75336830
135Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75209859
136Increased intramyocellular lipid droplets (HP:0012240)1.74560242
137Abnormality of the ileum (HP:0001549)1.73778053
138Vertebral compression fractures (HP:0002953)1.72813499
139Beaking of vertebral bodies (HP:0004568)1.72666627
140Interstitial pulmonary disease (HP:0006530)1.72521809
141Acute myeloid leukemia (HP:0004808)1.72101847
142Single umbilical artery (HP:0001195)1.72034001
143Abnormality of the fetal cardiovascular system (HP:0010948)1.72034001
144Abnormal umbilical cord blood vessels (HP:0011403)1.72034001
145Obstructive lung disease (HP:0006536)1.71610087
146Chronic obstructive pulmonary disease (HP:0006510)1.71610087
147Spastic paraparesis (HP:0002313)1.71567347
148Albinism (HP:0001022)1.71321015
149Deformed tarsal bones (HP:0008119)1.70079005
150Seborrheic dermatitis (HP:0001051)1.70018027
151Cellulitis (HP:0100658)1.69762178
152EMG: myopathic abnormalities (HP:0003458)1.68405405
153Opisthotonus (HP:0002179)1.67800912
154Pulmonary fibrosis (HP:0002206)1.67675768
155Increased serum lactate (HP:0002151)1.67229843
156Mitochondrial inheritance (HP:0001427)1.66506837
157Abnormality of fatty-acid metabolism (HP:0004359)1.66256964
158Megaloblastic anemia (HP:0001889)1.65339249
159Irregular epiphyses (HP:0010582)1.65263035
160Hypergammaglobulinemia (HP:0010702)1.64486405
161Abnormality of DNA repair (HP:0003254)1.64193595
162Ulnar deviation of the wrist (HP:0003049)1.64143278
163Secondary amenorrhea (HP:0000869)1.64128374
164Fasciculations (HP:0002380)1.63787249
165Mesangial abnormality (HP:0001966)1.62772440
166Small intestinal stenosis (HP:0012848)1.62289628
167Duodenal stenosis (HP:0100867)1.62289628
168Reduced subcutaneous adipose tissue (HP:0003758)1.62188147
169Exertional dyspnea (HP:0002875)1.61086347
170Cutaneous melanoma (HP:0012056)1.60830188
171Absent thumb (HP:0009777)1.60711433
172Abnormal trabecular bone morphology (HP:0100671)1.59996900
173Optic nerve coloboma (HP:0000588)1.57715059
174Neutropenia (HP:0001875)1.56406235
175Increased neuronal autofluorescent lipopigment (HP:0002074)1.54692805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.86120663
2BUB13.72606645
3SMG12.94079156
4CDC72.89690523
5WEE12.83140663
6EIF2AK12.59372925
7NME22.55407040
8MAP4K12.45931397
9STK162.45702864
10PRPF4B2.31683702
11PIM22.19887960
12TSSK62.17860152
13EPHB12.09423468
14EEF2K2.08855175
15EIF2AK31.96153129
16TRIB31.94354661
17BRSK21.89348217
18FLT31.84045976
19KDR1.79675284
20TESK21.79107838
21PASK1.78358508
22RPS6KA41.72947101
23NEK11.63826280
24EPHA21.59119840
25ACVR1B1.58449082
26KIT1.58256185
27ERN11.57307627
28NEK21.54111285
29CCNB11.53693197
30TGFBR11.52526991
31SCYL21.49907603
32PKN21.48556982
33BTK1.47532022
34VRK11.46199600
35JAK31.43279524
36ATR1.43096929
37PLK41.40397043
38ZAP701.39691557
39SIK11.39571140
40STK101.38641536
41CDK71.36262356
42LRRK21.36055051
43MAP2K31.33938784
44PDK21.28470908
45PAK41.27849296
46MAP3K101.24928115
47RPS6KB21.24208478
48BRSK11.24117404
49TESK11.22604557
50NEK91.22413869
51SRPK11.21705296
52NME11.20840085
53TEC1.19949100
54PLK11.17158909
55AURKB1.17081494
56TTK1.16220079
57ICK1.11247995
58EPHA31.09417911
59MAP3K81.08498870
60MAP3K111.06238986
61ILK1.06209209
62CDK41.04994083
63FGFR41.04967583
64TBK11.01040950
65LMTK21.00075075
66ARAF0.99345069
67TXK0.98476873
68IRAK40.97764768
69MAP3K140.96847214
70TYK20.96173421
71BCKDK0.92402933
72CDK80.92267526
73MKNK10.90796786
74DYRK30.85189823
75MAPKAPK30.84669387
76IRAK30.81273830
77CSF1R0.80150491
78TAOK20.79435411
79BLK0.78740635
80TLK10.73816636
81PIM10.71660551
82FER0.68333600
83CDK120.68287332
84CLK10.67407286
85PLK30.66923162
86CHEK20.66256550
87AURKA0.65580972
88ZAK0.62966406
89CHEK10.62746399
90PRKD20.62046300
91MAP3K30.61783171
92SYK0.58721693
93MST40.57818215
94CSNK1G30.57158356
95AKT20.57012727
96LYN0.55500778
97TGFBR20.54495940
98PRKCI0.53022006
99JAK10.52859494
100PRKD30.52612195
101PAK10.52514489
102MST1R0.52290019
103HIPK20.50812396
104IRAK20.50271127
105IKBKB0.49925486
106IRAK10.48943866
107ITK0.48861065
108TTN0.48493561
109GRK60.47858261
110MAPKAPK20.47809615
111MYLK0.47505136
112TAOK30.47381944
113MAP3K10.47216768
114PIK3CG0.46890032
115DAPK10.46528722
116CSNK2A10.45718663
117MAP2K20.44900602
118LIMK10.44676988
119STK40.44300550
120TAOK10.44090628
121MAP3K130.43696934
122LCK0.43447274
123SIK30.43399904
124PHKG10.43031243
125PHKG20.43031243
126RIPK40.42602160
127RPS6KA60.42211458
128CDK90.41556566
129BRD40.40972285
130ATM0.40885237
131PTK60.40484192
132MATK0.40202021
133MAPK110.40133048
134CSNK2A20.39925697
135CDK20.39633795
136IKBKE0.39463445
137TNK20.38300281
138RPS6KC10.33805843
139RPS6KL10.33805843
140TRIM280.33582813
141RIPK10.32533610
142DMPK0.32520527

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17696531
2Mismatch repair_Homo sapiens_hsa034303.98006935
3Base excision repair_Homo sapiens_hsa034103.16113298
4Ribosome_Homo sapiens_hsa030103.13047173
5Proteasome_Homo sapiens_hsa030502.79850972
6Homologous recombination_Homo sapiens_hsa034402.67756343
7Nucleotide excision repair_Homo sapiens_hsa034202.63282005
8Spliceosome_Homo sapiens_hsa030402.62376067
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59287302
10RNA polymerase_Homo sapiens_hsa030202.57847258
11Pyrimidine metabolism_Homo sapiens_hsa002402.27324382
12Cell cycle_Homo sapiens_hsa041102.26069792
13RNA transport_Homo sapiens_hsa030132.24275709
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21598381
15Fatty acid elongation_Homo sapiens_hsa000622.15048581
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04060257
17One carbon pool by folate_Homo sapiens_hsa006702.03647446
18Non-homologous end-joining_Homo sapiens_hsa034501.70388466
19Protein export_Homo sapiens_hsa030601.61970072
20Pyruvate metabolism_Homo sapiens_hsa006201.60333567
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59694900
22RNA degradation_Homo sapiens_hsa030181.52178361
23Fanconi anemia pathway_Homo sapiens_hsa034601.49043760
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47910987
25Antigen processing and presentation_Homo sapiens_hsa046121.40211496
26p53 signaling pathway_Homo sapiens_hsa041151.38306185
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35592113
28Autoimmune thyroid disease_Homo sapiens_hsa053201.33922149
29Primary immunodeficiency_Homo sapiens_hsa053401.32792868
30N-Glycan biosynthesis_Homo sapiens_hsa005101.30584946
31Sulfur metabolism_Homo sapiens_hsa009201.26970416
32Graft-versus-host disease_Homo sapiens_hsa053321.19001445
33Purine metabolism_Homo sapiens_hsa002301.16505270
34Herpes simplex infection_Homo sapiens_hsa051681.16458201
35Legionellosis_Homo sapiens_hsa051341.15291920
36Epstein-Barr virus infection_Homo sapiens_hsa051691.13359392
37Pentose phosphate pathway_Homo sapiens_hsa000301.11404385
38Basal transcription factors_Homo sapiens_hsa030221.07967531
39Other glycan degradation_Homo sapiens_hsa005111.06689865
40Asthma_Homo sapiens_hsa053101.03101072
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02593699
42Vibrio cholerae infection_Homo sapiens_hsa051101.01472530
43Measles_Homo sapiens_hsa051620.98248381
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96685693
45mRNA surveillance pathway_Homo sapiens_hsa030150.93265789
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92666524
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92562863
48Parkinsons disease_Homo sapiens_hsa050120.91631328
49Folate biosynthesis_Homo sapiens_hsa007900.91144188
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89599119
51HTLV-I infection_Homo sapiens_hsa051660.89068341
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88630573
53Thyroid cancer_Homo sapiens_hsa052160.86214537
54Leishmaniasis_Homo sapiens_hsa051400.85762645
55Viral carcinogenesis_Homo sapiens_hsa052030.84749445
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83528354
57Shigellosis_Homo sapiens_hsa051310.82331755
58Selenocompound metabolism_Homo sapiens_hsa004500.82213431
59Apoptosis_Homo sapiens_hsa042100.81669931
60Galactose metabolism_Homo sapiens_hsa000520.80763147
61Biosynthesis of amino acids_Homo sapiens_hsa012300.78025657
62Hepatitis C_Homo sapiens_hsa051600.77887520
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75330125
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75147413
65Hepatitis B_Homo sapiens_hsa051610.72943022
66Hematopoietic cell lineage_Homo sapiens_hsa046400.71974827
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.71580240
68Fatty acid metabolism_Homo sapiens_hsa012120.71168256
69Sulfur relay system_Homo sapiens_hsa041220.70573183
70Oxidative phosphorylation_Homo sapiens_hsa001900.67168901
71Small cell lung cancer_Homo sapiens_hsa052220.66872188
72Acute myeloid leukemia_Homo sapiens_hsa052210.65209369
73Chronic myeloid leukemia_Homo sapiens_hsa052200.63318717
74Carbon metabolism_Homo sapiens_hsa012000.61403058
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59802812
76Arginine and proline metabolism_Homo sapiens_hsa003300.59707974
77Type I diabetes mellitus_Homo sapiens_hsa049400.59313787
78Influenza A_Homo sapiens_hsa051640.57666950
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.57189972
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56033299
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55179990
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.54890897
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53662698
84Phenylalanine metabolism_Homo sapiens_hsa003600.53525576
85B cell receptor signaling pathway_Homo sapiens_hsa046620.53336531
86Salmonella infection_Homo sapiens_hsa051320.51554306
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51226815
88Huntingtons disease_Homo sapiens_hsa050160.50776428
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48642555
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48401709
91Viral myocarditis_Homo sapiens_hsa054160.47698382
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.47214612
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.46512423
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.46207148
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45625596
96Toxoplasmosis_Homo sapiens_hsa051450.45454759
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45369928
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43922630
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.43539148
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43275858
101Fructose and mannose metabolism_Homo sapiens_hsa000510.42539680
102Rheumatoid arthritis_Homo sapiens_hsa053230.42100233
103Renin-angiotensin system_Homo sapiens_hsa046140.41257575
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.39867050
105Pancreatic cancer_Homo sapiens_hsa052120.39448029
106Glutathione metabolism_Homo sapiens_hsa004800.39144752
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39045884
108Lysosome_Homo sapiens_hsa041420.37282706
109Phagosome_Homo sapiens_hsa041450.37066780
110Bladder cancer_Homo sapiens_hsa052190.35802694
111Colorectal cancer_Homo sapiens_hsa052100.35769760
112Notch signaling pathway_Homo sapiens_hsa043300.35502474
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34800983
114Metabolic pathways_Homo sapiens_hsa011000.34493305
115HIF-1 signaling pathway_Homo sapiens_hsa040660.34280769
116TNF signaling pathway_Homo sapiens_hsa046680.34206367
117Propanoate metabolism_Homo sapiens_hsa006400.33118775
118Pertussis_Homo sapiens_hsa051330.32544624
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32464189
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.32458129
121Malaria_Homo sapiens_hsa051440.32077821
122Osteoclast differentiation_Homo sapiens_hsa043800.30920886
123Oocyte meiosis_Homo sapiens_hsa041140.30714953
124Tuberculosis_Homo sapiens_hsa051520.29570536
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28678095
126T cell receptor signaling pathway_Homo sapiens_hsa046600.27688327
127Allograft rejection_Homo sapiens_hsa053300.27095946
128Systemic lupus erythematosus_Homo sapiens_hsa053220.26668843
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26201715

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