SLC34A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin filament depolymerization (GO:0030042)9.81750775
2collecting duct development (GO:0072044)9.36165815
3drug transport (GO:0015893)9.25533535
4organic cation transport (GO:0015695)8.90059817
5lysine catabolic process (GO:0006554)8.61870855
6lysine metabolic process (GO:0006553)8.61870855
7cardiovascular system development (GO:0072358)8.21733040
8quaternary ammonium group transport (GO:0015697)7.35373057
9glyoxylate metabolic process (GO:0046487)7.33274377
10drug catabolic process (GO:0042737)7.26191598
11exogenous drug catabolic process (GO:0042738)7.21664676
12phosphate ion transmembrane transport (GO:0035435)7.03191260
13response to water (GO:0009415)6.97064514
14positive regulation of catenin import into nucleus (GO:0035413)6.64618193
15cell volume homeostasis (GO:0006884)6.55723770
16cysteine metabolic process (GO:0006534)6.55713831
17* phosphate ion transport (GO:0006817)6.45633202
18positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.43828962
19positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)6.34287812
20excretion (GO:0007588)6.25560639
21activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)6.06369421
22negative regulation of cholesterol transport (GO:0032375)6.00558067
23negative regulation of sterol transport (GO:0032372)6.00558067
24nonribosomal peptide biosynthetic process (GO:0019184)5.88818861
25short-chain fatty acid metabolic process (GO:0046459)5.84666094
26aspartate family amino acid catabolic process (GO:0009068)5.82248059
27renal absorption (GO:0070293)5.77510464
28vitamin D metabolic process (GO:0042359)5.70905920
29toxin transport (GO:1901998)5.51746751
30branched-chain amino acid metabolic process (GO:0009081)5.49374696
31metanephric tubule development (GO:0072170)5.44905562
32metanephric nephron tubule development (GO:0072234)5.44905562
33mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.42064435
34negative regulation of metanephros development (GO:0072217)5.36042286
35regulation of apoptotic process involved in morphogenesis (GO:1902337)5.34462942
36nephron tubule formation (GO:0072079)5.33292907
37carnitine transport (GO:0015879)5.24961766
38amino-acid betaine transport (GO:0015838)5.24961766
39homocysteine metabolic process (GO:0050667)5.24844186
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.24401508
41L-phenylalanine metabolic process (GO:0006558)5.24401508
42glutathione biosynthetic process (GO:0006750)5.22333927
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.17449395
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.17039480
45L-phenylalanine catabolic process (GO:0006559)5.17039480
46regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.10091948
47proline metabolic process (GO:0006560)5.09128889
48regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.08762120
49valine metabolic process (GO:0006573)5.07524855
50hyperosmotic response (GO:0006972)5.02773627
51metanephric nephron epithelium development (GO:0072243)5.01989257
52aromatic amino acid family catabolic process (GO:0009074)5.01137033
53modified amino acid transport (GO:0072337)4.98410754
54serine family amino acid catabolic process (GO:0009071)4.97848409
55cellular modified amino acid catabolic process (GO:0042219)4.89791872
56serine family amino acid metabolic process (GO:0009069)4.81556097
57tryptophan catabolic process (GO:0006569)4.78458020
58indole-containing compound catabolic process (GO:0042436)4.78458020
59indolalkylamine catabolic process (GO:0046218)4.78458020
60metanephric epithelium development (GO:0072207)4.61610920
612-oxoglutarate metabolic process (GO:0006103)4.59083489
62amino-acid betaine metabolic process (GO:0006577)4.56668893
63fructose metabolic process (GO:0006000)4.56533382
64tryptophan metabolic process (GO:0006568)4.56340379
65response to copper ion (GO:0046688)4.55850220
66regulation of protein localization to cell surface (GO:2000008)4.55762699
67renal system process (GO:0003014)4.53252327
68fatty acid beta-oxidation (GO:0006635)4.52259866
69branched-chain amino acid catabolic process (GO:0009083)4.49004293
70negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.39491671
71nephron tubule development (GO:0072080)4.30962097
72* tricarboxylic acid metabolic process (GO:0072350)4.30156818
73peptide biosynthetic process (GO:0043043)4.24292101
74acetyl-CoA metabolic process (GO:0006084)4.22421464
75glomerular visceral epithelial cell development (GO:0072015)4.19921917
76inositol metabolic process (GO:0006020)4.18538534
77fatty acid oxidation (GO:0019395)4.17970004
78cellular ketone body metabolic process (GO:0046950)4.14491407
79L-methionine salvage (GO:0071267)4.13115605
80L-methionine biosynthetic process (GO:0071265)4.13115605
81amino acid salvage (GO:0043102)4.13115605
82carnitine metabolic process (GO:0009437)4.12427624
83lipid oxidation (GO:0034440)4.10099273
84NADH metabolic process (GO:0006734)4.07695174
85pattern specification involved in kidney development (GO:0061004)4.07575822
86S-adenosylmethionine metabolic process (GO:0046500)4.05562379
87peptide catabolic process (GO:0043171)4.02434739
88mammary gland alveolus development (GO:0060749)4.01599500
89ERK1 and ERK2 cascade (GO:0070371)4.01034699
90oligosaccharide catabolic process (GO:0009313)3.95912755
91serine family amino acid biosynthetic process (GO:0009070)3.95229273
92sodium-independent organic anion transport (GO:0043252)3.94645472
93cellular amino acid catabolic process (GO:0009063)3.94625502
94glutamate metabolic process (GO:0006536)3.93366591
95response to salt stress (GO:0009651)3.88522749
96positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.86121520
97alpha-amino acid catabolic process (GO:1901606)3.83047094
98cell differentiation involved in metanephros development (GO:0072202)3.82663295
99protein depolymerization (GO:0051261)3.82298421
100renal tubule development (GO:0061326)3.82223821
101glutathione metabolic process (GO:0006749)3.81470555
102* response to mercury ion (GO:0046689)3.76651746
103vitamin transport (GO:0051180)3.74249783
104fatty acid catabolic process (GO:0009062)3.73576068
105response to phenylpropanoid (GO:0080184)3.71955225
106aromatic amino acid family metabolic process (GO:0009072)3.71786974
107glomerular epithelial cell development (GO:0072310)3.68489507
108regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.67138517
109positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.66028235
110regulation of catenin import into nucleus (GO:0035412)3.62787807
111drug metabolic process (GO:0017144)3.61440732
112beta-amyloid metabolic process (GO:0050435)3.59318085
113organic acid catabolic process (GO:0016054)3.58213449
114carboxylic acid catabolic process (GO:0046395)3.58213449
115ketone body metabolic process (GO:1902224)3.56571070
116regulation of mesenchymal cell apoptotic process (GO:2001053)3.56347261
117nephron epithelium morphogenesis (GO:0072088)3.56121373
118nephron tubule morphogenesis (GO:0072078)3.56121373
119glutathione derivative biosynthetic process (GO:1901687)3.54452969
120glutathione derivative metabolic process (GO:1901685)3.54452969
121monocarboxylic acid catabolic process (GO:0072329)3.54305880
122mesonephros development (GO:0001823)3.53753543
123sulfur amino acid catabolic process (GO:0000098)3.53599314
124tricarboxylic acid cycle (GO:0006099)3.52787812
125regulation of cholesterol efflux (GO:0010874)3.51822121
126polyol transport (GO:0015791)3.50215104
127nephron epithelium development (GO:0072009)3.50066484
128sulfur compound transport (GO:0072348)3.48127992
129kynurenine metabolic process (GO:0070189)3.45804283
130regulation of fever generation (GO:0031620)3.45666758
131dicarboxylic acid metabolic process (GO:0043648)3.43725193
132cellular response to vitamin D (GO:0071305)3.42628918
133positive regulation of ERBB signaling pathway (GO:1901186)3.42006685
134succinate metabolic process (GO:0006105)3.40762161
135polyol catabolic process (GO:0046174)3.38688579
136response to lithium ion (GO:0010226)3.38175439
137indolalkylamine metabolic process (GO:0006586)3.38005137
138biotin metabolic process (GO:0006768)3.35999965
139benzene-containing compound metabolic process (GO:0042537)3.32857613
140glutamine family amino acid catabolic process (GO:0009065)3.31544963
141glycine metabolic process (GO:0006544)3.31244079
142pyrimidine ribonucleoside catabolic process (GO:0046133)3.30646005
143positive regulation of heat generation (GO:0031652)3.30077207
144uronic acid metabolic process (GO:0006063)3.29270606
145glucuronate metabolic process (GO:0019585)3.29270606
146urogenital system development (GO:0001655)3.27409527
147sulfur amino acid biosynthetic process (GO:0000097)3.26288319
148chloride transmembrane transport (GO:1902476)3.24925121
149regulation of potassium ion transmembrane transporter activity (GO:1901016)3.24621600
150inorganic anion transmembrane transport (GO:0098661)3.24581462
151methionine biosynthetic process (GO:0009086)3.23379586
152regulation of stem cell maintenance (GO:2000036)3.22224102
153sodium ion homeostasis (GO:0055078)3.17807508
154positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.16583002
155regulation of plasminogen activation (GO:0010755)3.11955654
156negative regulation of kidney development (GO:0090185)3.10371954
157regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.06573850
158epoxygenase P450 pathway (GO:0019373)3.04026812
159mesenchymal cell differentiation involved in kidney development (GO:0072161)3.03239330
160mesenchymal cell differentiation involved in renal system development (GO:2001012)3.03239330
161chloride transport (GO:0006821)3.01145293
162flavonoid metabolic process (GO:0009812)2.91900355
163regulation of calcium ion import (GO:0090279)2.89860710
164* sodium ion transport (GO:0006814)2.88839685
165regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.87519758
166methionine metabolic process (GO:0006555)2.87505265
167* inorganic anion transport (GO:0015698)2.83235266
168kidney epithelium development (GO:0072073)2.82199239
169histamine transport (GO:0051608)2.81532481
170negative regulation of lipid transport (GO:0032369)2.76692410
171urate metabolic process (GO:0046415)11.1153703
172drug transmembrane transport (GO:0006855)10.9721127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.50895439
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.41199829
3GATA1_22025678_ChIP-Seq_K562_Human5.25953235
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.52762512
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34803424
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.91451218
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.76302551
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27196537
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.88846929
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.87185748
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.67802369
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61691527
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.57646440
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52388387
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44419012
16AR_21909140_ChIP-Seq_LNCAP_Human2.37750096
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.33694396
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.25598448
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.21189361
20CLOCK_20551151_ChIP-Seq_293T_Human2.20289806
21DROSHA_22980978_ChIP-Seq_HELA_Human2.16844526
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.14199959
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87767220
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78654635
25* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77344732
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76399415
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73334990
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.68009660
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.64574791
30VDR_22108803_ChIP-Seq_LS180_Human1.63105692
31P53_22127205_ChIP-Seq_FIBROBLAST_Human1.62397591
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60691316
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.59628869
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53264606
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51751570
36KLF4_18555785_Chip-Seq_ESCs_Mouse1.50505508
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49910894
38* LXR_22292898_ChIP-Seq_THP-1_Human1.49686949
39GATA4_25053715_ChIP-Seq_YYC3_Human1.48475532
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.44491183
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43779705
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43714347
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41542029
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.38680796
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37823814
46RACK7_27058665_Chip-Seq_MCF-7_Human1.37524651
47CBP_21632823_ChIP-Seq_H3396_Human1.37002124
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35798685
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35630604
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.33467753
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32492071
52EGR1_19032775_ChIP-ChIP_M12_Human1.31868587
53OCT1_27270436_Chip-Seq_PROSTATE_Human1.31214725
54GBX2_23144817_ChIP-Seq_PC3_Human1.30515126
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.25874193
56KDM2B_26808549_Chip-Seq_REH_Human1.25579612
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25425707
58CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25095587
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24558434
60PHF8_20622853_ChIP-Seq_HELA_Human1.22559062
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21812495
62TCF4_22108803_ChIP-Seq_LS180_Human1.21580591
63SMAD4_21799915_ChIP-Seq_A2780_Human1.21327170
64P300_18555785_Chip-Seq_ESCs_Mouse1.21312626
65FOXH1_21741376_ChIP-Seq_ESCs_Human1.20402732
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19469413
67GATA6_25053715_ChIP-Seq_YYC3_Human1.19057397
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.18452469
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.18452469
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.17759315
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16715352
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16242289
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15922062
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.14930353
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.13692722
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12751558
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10892773
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10451492
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09686162
80ESET_19884257_ChIP-Seq_ESCs_Mouse1.09102672
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08694028
82NFYA_21822215_ChIP-Seq_K562_Human1.08276976
83RXR_22108803_ChIP-Seq_LS180_Human1.07668065
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.06617778
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06375619
86AHR_22903824_ChIP-Seq_MCF-7_Human1.05763036
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03881135
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03459164
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03316235
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02380780
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02380780
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01990173
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01844927
94ZFX_18555785_Chip-Seq_ESCs_Mouse1.01726415
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01271179
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00233258
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99661102
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.99420267
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98629721
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98286455
101PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98206664
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.97454527
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97431434
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97378228
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96930679
106TBL1_22424771_ChIP-Seq_293T_Human0.96508920
107HNFA_21074721_ChIP-Seq_CACO-2_Human0.96397006
108ERG_21242973_ChIP-ChIP_JURKAT_Human0.96111930
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93668383
110SOX2_20726797_ChIP-Seq_SW620_Human0.93101619
111SOX2_18555785_Chip-Seq_ESCs_Mouse0.93083057
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92535296
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92516621
114ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92250466
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92167759
116BCAT_22108803_ChIP-Seq_LS180_Human0.92039999
117ER_23166858_ChIP-Seq_MCF-7_Human0.91356537
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91133953
119ETV1_20927104_ChIP-Seq_GIST48_Human0.90431202
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89787672
121PU1_27457419_Chip-Seq_LIVER_Mouse0.89637408
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.89419104
123P53_22387025_ChIP-Seq_ESCs_Mouse0.89343136
124* OCT4_20526341_ChIP-Seq_ESCs_Human0.88678616
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88364581
126RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88089787
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87876649
128CDX2_22108803_ChIP-Seq_LS180_Human0.87662887
129STAT3_23295773_ChIP-Seq_U87_Human0.87508841
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87470676
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.86088989
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.85550028
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85417123
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85381724
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84377040
136MYC_19915707_ChIP-ChIP_AK7_Human0.83417433
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82197707
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81852641
139* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81729468
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80730021
141NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79330330
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79268256
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77393224
144TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76794390
145KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75005611
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74766853
147CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73533944
148TAF2_19829295_ChIP-Seq_ESCs_Human0.72657889
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72531781
150* RAC3_21632823_ChIP-Seq_H3396_Human0.71755712
151GATA2_19941826_ChIP-Seq_K562_Human0.70989452
152MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70035046
153P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69962219
154TET1_21451524_ChIP-Seq_MESCs_Mouse0.69953742
155CREB1_26743006_Chip-Seq_LNCaP_Human0.69847429
156CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69160980
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69076935
158SOX11_22085726_ChIP-Seq_ESNs_Mouse0.68404731
159* SMC4_20622854_ChIP-Seq_HELA_Human0.67062790
160* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66972157
161VDR_24787735_ChIP-Seq_THP-1_Human0.66746402
162FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66279767
163WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66214074
164EOMES_21245162_ChIP-Seq_HESCs_Human0.65170609
165* TP63_23658742_ChIP-Seq_EP156T_Human0.65080658
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.64742804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.89952717
2MP0004043_abnormal_pH_regulation6.87664338
3MP0005332_abnormal_amino_acid5.11922001
4MP0002139_abnormal_hepatobiliary_system4.88941190
5* MP0004019_abnormal_vitamin_homeostasis4.21695853
6MP0003195_calcinosis4.13867616
7* MP0009643_abnormal_urine_homeostasis3.94599459
8MP0002138_abnormal_hepatobiliary_system3.86056277
9* MP0001765_abnormal_ion_homeostasis3.72592880
10MP0001756_abnormal_urination3.22278784
11* MP0005636_abnormal_mineral_homeostasis3.04933502
12* MP0002136_abnormal_kidney_physiology2.95151881
13MP0008875_abnormal_xenobiotic_pharmacok2.94866027
14MP0005377_hearing/vestibular/ear_phenot2.94528613
15MP0003878_abnormal_ear_physiology2.94528613
16MP0001958_emphysema2.75665693
17MP0003252_abnormal_bile_duct2.44129739
18MP0005365_abnormal_bile_salt2.22467575
19MP0005058_abnormal_lysosome_morphology2.20127254
20MP0005085_abnormal_gallbladder_physiolo2.13688548
21MP0001270_distended_abdomen1.89443534
22MP0003186_abnormal_redox_activity1.89225472
23MP0004885_abnormal_endolymph1.87743728
24MP0008961_abnormal_basal_metabolism1.82061680
25MP0000538_abnormal_urinary_bladder1.71152106
26MP0005584_abnormal_enzyme/coenzyme_acti1.70364988
27MP0003183_abnormal_peptide_metabolism1.63460660
28MP0005084_abnormal_gallbladder_morpholo1.43689040
29MP0005451_abnormal_body_composition1.41587655
30MP0003045_fibrosis1.40706635
31MP0003806_abnormal_nucleotide_metabolis1.35290318
32MP0006036_abnormal_mitochondrial_physio1.34900390
33MP0003300_gastrointestinal_ulcer1.32394982
34MP0000230_abnormal_systemic_arterial1.28226852
35MP0002168_other_aberrant_phenotype1.28224304
36MP0002928_abnormal_bile_duct1.27888848
37MP0002876_abnormal_thyroid_physiology1.23086028
38MP0005670_abnormal_white_adipose1.19417883
39* MP0005319_abnormal_enzyme/_coenzyme1.18645456
40MP0002135_abnormal_kidney_morphology1.14762471
41MP0005535_abnormal_body_temperature1.08874827
42MP0005666_abnormal_adipose_tissue1.05743536
43MP0004147_increased_porphyrin_level1.05516722
44MP0001764_abnormal_homeostasis1.01361034
45MP0002089_abnormal_postnatal_growth/wei0.96430091
46MP0003283_abnormal_digestive_organ0.91069981
47MP0002118_abnormal_lipid_homeostasis0.90354783
48MP0003172_abnormal_lysosome_physiology0.90138554
49MP0001666_abnormal_nutrient_absorption0.87551783
50MP0008872_abnormal_physiological_respon0.82826444
51MP0003646_muscle_fatigue0.81443731
52MP0004264_abnormal_extraembryonic_tissu0.80624503
53MP0003638_abnormal_response/metabolism_0.80617388
54MP0003191_abnormal_cellular_cholesterol0.78794960
55* MP0009642_abnormal_blood_homeostasis0.76178399
56MP0009764_decreased_sensitivity_to0.75514339
57MP0010234_abnormal_vibrissa_follicle0.67832422
58MP0001485_abnormal_pinna_reflex0.67528772
59MP0001661_extended_life_span0.67519544
60MP0005220_abnormal_exocrine_pancreas0.64711901
61MP0000371_diluted_coat_color0.64196222
62* MP0002896_abnormal_bone_mineralization0.63758877
63MP0000609_abnormal_liver_physiology0.63611987
64MP0005395_other_phenotype0.63212382
65MP0010329_abnormal_lipoprotein_level0.62808556
66MP0001191_abnormal_skin_condition0.62389522
67MP0002796_impaired_skin_barrier0.61476632
68MP0003959_abnormal_lean_body0.58285641
69MP0004742_abnormal_vestibular_system0.56445779
70MP0003329_amyloid_beta_deposits0.56158454
71MP0005408_hypopigmentation0.56102697
72MP0003879_abnormal_hair_cell0.54282826
73MP0000598_abnormal_liver_morphology0.53644327
74MP0005165_increased_susceptibility_to0.51617046
75MP0000678_abnormal_parathyroid_gland0.50617697
76MP0003941_abnormal_skin_development0.50488370
77MP0001944_abnormal_pancreas_morphology0.49902947
78MP0005501_abnormal_skin_physiology0.49523884
79MP0000026_abnormal_inner_ear0.49329531
80MP0002998_abnormal_bone_remodeling0.49279741
81MP0002078_abnormal_glucose_homeostasis0.49217770
82MP0003943_abnormal_hepatobiliary_system0.49207183
83MP0004858_abnormal_nervous_system0.48126255
84MP0006035_abnormal_mitochondrial_morpho0.47460639
85MP0010386_abnormal_urinary_bladder0.46312744
86MP0005375_adipose_tissue_phenotype0.45689745
87* MP0008469_abnormal_protein_level0.45414458
88MP0005646_abnormal_pituitary_gland0.44052690
89MP0000013_abnormal_adipose_tissue0.43619471
90MP0004484_altered_response_of0.43555783
91MP0001663_abnormal_digestive_system0.43126566
92MP0003221_abnormal_cardiomyocyte_apopto0.42349108
93* MP0002115_abnormal_skeleton_extremities0.40511256
94MP0004272_abnormal_basement_membrane0.39816378
95* MP0003953_abnormal_hormone_level0.39603128
96MP0003705_abnormal_hypodermis_morpholog0.37734743
97MP0005167_abnormal_blood-brain_barrier0.36064145
98* MP0002069_abnormal_eating/drinking_beha0.35708929
99* MP0003795_abnormal_bone_structure0.35273847
100MP0002098_abnormal_vibrissa_morphology0.34884744
101MP0001963_abnormal_hearing_physiology0.34559526
102MP0000003_abnormal_adipose_tissue0.33887971
103MP0000534_abnormal_ureter_morphology0.33847980
104MP0000631_abnormal_neuroendocrine_gland0.33205014
105MP0005410_abnormal_fertilization0.32462368
106MP0003724_increased_susceptibility_to0.31163447
107MP0003075_altered_response_to0.29881432
108MP0002971_abnormal_brown_adipose0.29611166
109MP0010368_abnormal_lymphatic_system0.29358199
110MP0001177_atelectasis0.28179324
111MP0001664_abnormal_digestion0.27849521
112MP0005381_digestive/alimentary_phenotyp0.27416962
113MP0009780_abnormal_chondrocyte_physiolo0.27334213
114MP0005166_decreased_susceptibility_to0.26880445
115MP0000566_synostosis0.26465413
116MP0003938_abnormal_ear_development0.26456166
117* MP0001731_abnormal_postnatal_growth0.25914191
118MP0005620_abnormal_muscle_contractility0.25365689
119MP0008874_decreased_physiological_sensi0.25301195
120MP0002132_abnormal_respiratory_system0.24339208
121MP0001486_abnormal_startle_reflex0.24119526
122MP0002108_abnormal_muscle_morphology0.20609620
123MP0003942_abnormal_urinary_system0.20538791
124MP0004233_abnormal_muscle_weight0.19464144
125MP0004130_abnormal_muscle_cell0.19341603
126MP0000681_abnormal_thyroid_gland0.18249743
127MP0005452_abnormal_adipose_tissue0.18191469
128MP0000367_abnormal_coat/_hair0.17458273
129MP0009115_abnormal_fat_cell0.15615288
130MP0001845_abnormal_inflammatory_respons0.15578776
131MP0005367_renal/urinary_system_phenotyp0.15490964
132MP0000516_abnormal_urinary_system0.15490964
133MP0004215_abnormal_myocardial_fiber0.14570433
134MP0000762_abnormal_tongue_morphology0.14466093
135MP0001784_abnormal_fluid_regulation0.13525327
136MP0005376_homeostasis/metabolism_phenot0.13509095
137MP0005409_darkened_coat_color0.12257116
138MP0003011_delayed_dark_adaptation0.12185712
139MP0008004_abnormal_stomach_pH0.11783429

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.18200092
2Hypokalemic alkalosis (HP:0001949)7.65955771
3Metabolic alkalosis (HP:0200114)7.55954820
4Hypomagnesemia (HP:0002917)7.08150416
5Gout (HP:0001997)7.03665643
6Hyperactive renin-angiotensin system (HP:0000841)7.00624912
7Polyuria (HP:0000103)6.86618209
8Abnormality of chloride homeostasis (HP:0011422)6.47162693
9Abnormal urine output (HP:0012590)6.41635325
10Abnormality of renal excretion (HP:0011036)6.12505151
11Abnormality of magnesium homeostasis (HP:0004921)6.00819768
12Abnormal drinking behavior (HP:0030082)5.59226014
13Polydipsia (HP:0001959)5.59226014
14Abnormality of renin-angiotensin system (HP:0000847)5.04828243
15Alkalosis (HP:0001948)5.03616394
16Increased purine levels (HP:0004368)5.02310972
17Hyperuricemia (HP:0002149)5.02310972
18Renal salt wasting (HP:0000127)4.91812161
19Tetany (HP:0001281)4.91749688
20Hyperaldosteronism (HP:0000859)4.83306741
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.82624704
22Hyperglycinuria (HP:0003108)4.80978068
23Abnormality of purine metabolism (HP:0004352)4.47708898
24Abnormality of serine family amino acid metabolism (HP:0010894)3.95265050
25Abnormality of glycine metabolism (HP:0010895)3.95265050
26Hypokalemia (HP:0002900)3.86511666
27Ketoacidosis (HP:0001993)3.66448133
28Renal tubular acidosis (HP:0001947)3.65907842
29* Proximal tubulopathy (HP:0000114)3.60858524
30* Hypercalciuria (HP:0002150)3.36452304
31Abnormality of nucleobase metabolism (HP:0010932)3.33143402
32Delayed epiphyseal ossification (HP:0002663)3.29111507
33Ketosis (HP:0001946)3.27536490
34Large eyes (HP:0001090)3.26982092
35Abnormality of potassium homeostasis (HP:0011042)3.26057939
36Abnormality of proline metabolism (HP:0010907)3.25251516
37Hydroxyprolinuria (HP:0003080)3.25251516
38Nephrocalcinosis (HP:0000121)3.04877288
39* Glycosuria (HP:0003076)2.85477888
40* Abnormality of urine glucose concentration (HP:0011016)2.85477888
41Abnormality of fatty-acid metabolism (HP:0004359)2.77426554
42Hyperglycinemia (HP:0002154)2.73950045
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72627222
44Metaphyseal cupping (HP:0003021)2.68304615
45Vascular calcification (HP:0004934)2.68139374
46Delayed CNS myelination (HP:0002188)2.61536216
47Widely patent fontanelles and sutures (HP:0004492)2.54760451
48Vacuolated lymphocytes (HP:0001922)2.52970668
49* Nephrolithiasis (HP:0000787)2.52576300
50Abnormality of sodium homeostasis (HP:0010931)2.50433025
51Dehydration (HP:0001944)2.49737960
52Hyponatremia (HP:0002902)2.47946903
53Hyperammonemia (HP:0001987)2.44484491
54Cardiovascular calcification (HP:0011915)2.39389002
55Abnormality of renal resorption (HP:0011038)2.37820340
56Dicarboxylic aciduria (HP:0003215)2.37261519
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37261519
58Vomiting (HP:0002013)2.30487839
59Renal tubular dysfunction (HP:0000124)2.27679412
60Enlarged kidneys (HP:0000105)2.27107098
61Metabolic acidosis (HP:0001942)2.26793335
62Thin bony cortex (HP:0002753)2.25260126
63* Abnormal urine phosphate concentration (HP:0012599)2.23933267
64Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23170819
65Adrenal overactivity (HP:0002717)2.22337507
66* Hyperphosphaturia (HP:0003109)2.20161250
67Malnutrition (HP:0004395)2.19590186
68Confusion (HP:0001289)2.18874183
69Bilateral sensorineural hearing impairment (HP:0008619)2.10550748
70Methylmalonic aciduria (HP:0012120)2.07208024
71Abnormal tarsal ossification (HP:0008369)2.06924275
72* Hypophosphatemia (HP:0002148)2.05520718
73Chondrocalcinosis (HP:0000934)2.04700269
74Lethargy (HP:0001254)2.03288608
75Abnormality of sulfur amino acid metabolism (HP:0004339)2.03112888
76Tubular atrophy (HP:0000092)1.98090633
77Lymphangioma (HP:0100764)1.98089998
78Abnormality of the costochondral junction (HP:0000919)1.98055895
79Tubulointerstitial fibrosis (HP:0005576)1.96059699
80Decreased circulating renin level (HP:0003351)1.91755069
81Abnormality of Sharpey fibers (HP:0100685)1.91598549
82Focal segmental glomerulosclerosis (HP:0000097)1.89991586
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87999733
84Nausea (HP:0002018)1.83242703
85Irritability (HP:0000737)1.82751976
86Metaphyseal irregularity (HP:0003025)1.82121102
87Glomerulosclerosis (HP:0000096)1.81645805
88Facial shape deformation (HP:0011334)1.79775668
89Potter facies (HP:0002009)1.79775668
90Bicornuate uterus (HP:0000813)1.79240845
91Metaphyseal dysplasia (HP:0100255)1.77392744
92Impaired platelet aggregation (HP:0003540)1.75093948
93Abnormal platelet function (HP:0011869)1.75093948
94Abnormality of serum amino acid levels (HP:0003112)1.71082193
95Hypotension (HP:0002615)1.70972809
96Neonatal onset (HP:0003623)1.69784658
97Generalized muscle weakness (HP:0003324)1.69413734
98Sensorimotor neuropathy (HP:0007141)1.67946443
99Tachypnea (HP:0002789)1.67456827
100Axonal loss (HP:0003447)1.65199463
101* Abnormal enzyme/coenzyme activity (HP:0012379)1.61944323
102Hyperkalemia (HP:0002153)1.61175163
103* Rickets (HP:0002748)1.61009336
104Abnormality of carpal bone ossification (HP:0006257)1.60086063
105Nephrogenic diabetes insipidus (HP:0009806)1.43767609
106Premature birth (HP:0001622)1.38319638
107Esophageal varix (HP:0002040)1.37356467
108Paresthesia (HP:0003401)1.36477510
109Abnormality of the renal medulla (HP:0100957)1.36440521
110Small for gestational age (HP:0001518)1.20321001
111Tubulointerstitial abnormality (HP:0001969)1.09655988
112Intellectual disability, moderate (HP:0002342)1.08437141
113Hypothermia (HP:0002045)1.03455387
114Polyhydramnios (HP:0001561)1.01488807
115Abnormality of calcium-phosphate metabolism (HP:0100530)1.00302639
116Chorioretinal atrophy (HP:0000533)0.98395708
117Neonatal death (HP:0003811)0.97490101
118Osteomalacia (HP:0002749)0.95836942
119Persistence of primary teeth (HP:0006335)0.94818005
120Visceral angiomatosis (HP:0100761)0.93907957
121Abnormality of macular pigmentation (HP:0008002)0.92036140
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)0.90899491
123Abnormality of alanine metabolism (HP:0010916)0.90899491
124Hyperalaninemia (HP:0003348)0.90899491
125Thyroid-stimulating hormone excess (HP:0002925)0.90423249
126Congenital sensorineural hearing impairment (HP:0008527)0.90021145
127Enlarged epiphyses (HP:0010580)0.88193735
128Hypophosphatemic rickets (HP:0004912)0.85435534
129Hemangiomatosis (HP:0007461)0.83596174
130Abnormality of the fingertips (HP:0001211)0.80347541
131Hyperphosphatemia (HP:0002905)0.80016558
132* Osteopenia (HP:0000938)0.76848971
133Megaloblastic anemia (HP:0001889)0.76848949
134Paralysis (HP:0003470)0.72450889
135Abnormal foot bone ossification (HP:0010675)0.71401464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.53936393
2WNK37.72298492
3OXSR17.59720747
4STK394.86057800
5BCKDK2.97117248
6STK38L2.34425868
7WNK12.03155622
8NEK11.96507398
9PDK41.92498765
10PDK31.92498765
11SGK4941.82825582
12SGK2231.82825582
13PDK21.40466118
14STK381.28122911
15MST1R1.04571513
16MST41.03933018
17SGK20.94122530
18FGFR40.92194201
19LRRK20.91145015
20SGK30.90292243
21PINK10.79023267
22EPHB10.77556954
23GRK60.75958076
24GSK3A0.73111804
25TIE10.63126266
26SGK10.58345561
27MAP3K70.57553976
28TGFBR20.55254406
29ACVR1B0.55070519
30DYRK1B0.54713156
31PTK20.51973165
32PAK40.49248889
33ABL20.47730722
34MAP3K30.45286044
35PRKAA10.45163754
36PDPK10.43244777
37MAPK110.42490119
38ERN10.42300081
39PTK60.39805234
40TRIB30.39401674
41JAK30.37738131
42PAK30.32739358
43PRKAA20.32464556
44INSRR0.32133706
45FGR0.31271685
46PRKCI0.30845815
47PRKD20.30344655
48MET0.29556292
49STK100.29546102
50PTK2B0.29313107
51PDK10.29225569
52NME20.28804157
53FER0.28200926
54PRKCZ0.25974753
55NTRK10.25354236
56STK110.24089828
57RIPK10.23831961
58MAP4K10.23237707
59CDK90.22830327
60MYLK0.22547043
61NTRK30.22378671
62IRAK20.20199030
63PRKCD0.18674136
64PRKACG0.17793037
65MAP3K20.17210625
66PRKCH0.16713184
67MAPK150.15704317
68RPS6KB20.15680401
69LATS10.14757546
70MINK10.13616632
71FRK0.13488021
72ADRBK20.13440296
73AKT20.12857863
74MAP3K140.12363856
75TESK10.12292027
76MAP2K30.12136906
77EPHA40.11826517
78BMX0.11420970
79PRKCA0.10721900
80ERBB40.10587257
81CDK120.10531401
82PIM10.10425690
83SCYL20.10161867
84PRKACA0.09712708
85MAP2K10.09701297
86JAK20.09535783
87MAPK120.08763557
88MAP2K40.08180683
89DDR20.07811978
90FGFR30.07173918
91BTK0.06983127
92NTRK20.06789285
93CDK190.06124947
94IRAK10.06068685
95ROCK10.05811675
96IRAK30.04673498
97INSR0.04332370
98MAP3K110.03859333
99NEK60.03561826
100FGFR20.03268880
101AURKA0.03267359
102PRKCB0.02852400
103PRKCG0.02844866
104STK30.02673165
105CSF1R0.02525094
106SRC0.02521715
107KSR20.02357974
108KDR0.02266685
109TXK0.02121606
110BRSK20.01960880
111ADRBK10.01611115
112RPS6KB10.01448599
113CSK0.00845924
114MTOR0.00507660
115MAPK80.00363841
116CAMK40.00093961
117CAMK2B-0.0534074
118TNK2-0.0530825
119RET-0.0525712
120LCK-0.0494706
121PRKCE-0.0485663
122ABL1-0.0440862
123CCNB1-0.0422636
124EGFR-0.0407314
125SMG1-0.0401550
126FYN-0.0390016
127PIK3CA-0.0384924
128CAMK1G-0.0346295
129PIK3CG-0.0337832
130TAOK1-0.0317435
131PDGFRA-0.0296055
132ITK-0.0276659
133HIPK2-0.0226913
134PRKG2-0.0176393
135IGF1R-0.0169209
136PRKACB-0.0158768
137CSNK1A1-0.0154058
138TRPM7-0.0139231
139LMTK2-0.0136182
140PRPF4B-0.0121783
141RPS6KA1-0.0118048
142RPS6KA3-0.0098809
143MAPK4-0.0092799
144AKT3-0.0055770
145PRKD3-0.0048838
146YES1-0.0026821
147SYK-0.0012345
148PRKCQ-0.0003672

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.74292129
2Butanoate metabolism_Homo sapiens_hsa006503.70356054
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.50473820
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50371824
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49120630
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.20625882
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.15901525
8Propanoate metabolism_Homo sapiens_hsa006403.14979036
9Pentose and glucuronate interconversions_Homo sapiens_hsa000403.00414205
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.64113237
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60350254
12Peroxisome_Homo sapiens_hsa041462.41793206
13Pyruvate metabolism_Homo sapiens_hsa006202.41657420
14Collecting duct acid secretion_Homo sapiens_hsa049662.32870699
15Fatty acid degradation_Homo sapiens_hsa000712.32037829
16Tryptophan metabolism_Homo sapiens_hsa003802.18299395
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13936697
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01319854
19Vitamin digestion and absorption_Homo sapiens_hsa049771.96782052
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90068616
21beta-Alanine metabolism_Homo sapiens_hsa004101.88470519
22Fatty acid metabolism_Homo sapiens_hsa012121.72724699
23Sulfur metabolism_Homo sapiens_hsa009201.69914159
24Carbon metabolism_Homo sapiens_hsa012001.69418912
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64571178
26Bile secretion_Homo sapiens_hsa049761.59278382
27Glutathione metabolism_Homo sapiens_hsa004801.58168560
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54676792
29Arginine and proline metabolism_Homo sapiens_hsa003301.45323093
30Other glycan degradation_Homo sapiens_hsa005111.29014314
31Lysine degradation_Homo sapiens_hsa003101.26947567
32Mineral absorption_Homo sapiens_hsa049781.24835364
33Protein digestion and absorption_Homo sapiens_hsa049741.24719759
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18034992
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17910479
36Starch and sucrose metabolism_Homo sapiens_hsa005001.16663983
37PPAR signaling pathway_Homo sapiens_hsa033201.16549626
38Arginine biosynthesis_Homo sapiens_hsa002201.16322105
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.08700057
40Nitrogen metabolism_Homo sapiens_hsa009101.06822327
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05490126
42Non-small cell lung cancer_Homo sapiens_hsa052231.03712059
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01608917
44Histidine metabolism_Homo sapiens_hsa003401.00544683
45Biosynthesis of amino acids_Homo sapiens_hsa012300.99365883
46Phenylalanine metabolism_Homo sapiens_hsa003600.98933155
47Selenocompound metabolism_Homo sapiens_hsa004500.97694874
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97180252
49Endometrial cancer_Homo sapiens_hsa052130.96352107
50Folate biosynthesis_Homo sapiens_hsa007900.96348375
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94225424
52Complement and coagulation cascades_Homo sapiens_hsa046100.90159964
53Glycerolipid metabolism_Homo sapiens_hsa005610.89340502
54Glioma_Homo sapiens_hsa052140.88803792
55Fructose and mannose metabolism_Homo sapiens_hsa000510.83839722
56Pancreatic cancer_Homo sapiens_hsa052120.83433987
57Melanoma_Homo sapiens_hsa052180.76714465
58Oxidative phosphorylation_Homo sapiens_hsa001900.76214632
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.70526948
60Renin-angiotensin system_Homo sapiens_hsa046140.70175884
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68229725
62Fatty acid elongation_Homo sapiens_hsa000620.66637407
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.66352107
64Fatty acid biosynthesis_Homo sapiens_hsa000610.65063024
65Pentose phosphate pathway_Homo sapiens_hsa000300.61780663
66Lysosome_Homo sapiens_hsa041420.61153476
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.60655562
68Chemical carcinogenesis_Homo sapiens_hsa052040.58719984
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56169555
70Thyroid hormone synthesis_Homo sapiens_hsa049180.55626605
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.54533299
72FoxO signaling pathway_Homo sapiens_hsa040680.52693655
73Metabolic pathways_Homo sapiens_hsa011000.52392513
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.51964352
75Gastric acid secretion_Homo sapiens_hsa049710.47080872
76GABAergic synapse_Homo sapiens_hsa047270.46362228
77ErbB signaling pathway_Homo sapiens_hsa040120.45090434
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44882989
79Retinol metabolism_Homo sapiens_hsa008300.42161093
80Prostate cancer_Homo sapiens_hsa052150.42113068
81Thyroid cancer_Homo sapiens_hsa052160.41989478
82Parkinsons disease_Homo sapiens_hsa050120.40755989
83Hepatitis C_Homo sapiens_hsa051600.38731545
84Gap junction_Homo sapiens_hsa045400.38411706
85Vibrio cholerae infection_Homo sapiens_hsa051100.37069976
86Steroid biosynthesis_Homo sapiens_hsa001000.32482448
87Arachidonic acid metabolism_Homo sapiens_hsa005900.32010446
88Taste transduction_Homo sapiens_hsa047420.31716938
89Synaptic vesicle cycle_Homo sapiens_hsa047210.30538611
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29908126
91Morphine addiction_Homo sapiens_hsa050320.26290641
92Tyrosine metabolism_Homo sapiens_hsa003500.26045429
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25112477
94Vitamin B6 metabolism_Homo sapiens_hsa007500.24432278
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23182978
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22438206
97ABC transporters_Homo sapiens_hsa020100.22269204
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22086776
99Sulfur relay system_Homo sapiens_hsa041220.20378673
100Choline metabolism in cancer_Homo sapiens_hsa052310.18345640
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17691791
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.17076643
103HIF-1 signaling pathway_Homo sapiens_hsa040660.16363200
104Cardiac muscle contraction_Homo sapiens_hsa042600.14528184
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13751842
106Serotonergic synapse_Homo sapiens_hsa047260.12770202
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11745650
108Alzheimers disease_Homo sapiens_hsa050100.11181980
109Caffeine metabolism_Homo sapiens_hsa002320.10809262
110Sphingolipid metabolism_Homo sapiens_hsa006000.10058700
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.08299259
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.08289083
113Inositol phosphate metabolism_Homo sapiens_hsa005620.07895040
114Insulin resistance_Homo sapiens_hsa049310.07760810
115Renin secretion_Homo sapiens_hsa049240.07651032
116Galactose metabolism_Homo sapiens_hsa000520.07060486
117Rheumatoid arthritis_Homo sapiens_hsa053230.06877724
118AMPK signaling pathway_Homo sapiens_hsa041520.01249650
119Huntingtons disease_Homo sapiens_hsa050160.00076469
120Phagosome_Homo sapiens_hsa04145-0.0928074
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0706228
122One carbon pool by folate_Homo sapiens_hsa00670-0.0524248
123Bladder cancer_Homo sapiens_hsa05219-0.0365297
124alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0338935
125Glucagon signaling pathway_Homo sapiens_hsa04922-0.0233483

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