SLC2A14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)4.67785731
2plasma lipoprotein particle assembly (GO:0034377)4.60055852
3regulation of gene silencing by RNA (GO:0060966)4.33293623
4regulation of posttranscriptional gene silencing (GO:0060147)4.33293623
5regulation of gene silencing by miRNA (GO:0060964)4.33293623
6regulation of meiosis I (GO:0060631)4.03046653
7synapsis (GO:0007129)3.95743016
8protein-lipid complex assembly (GO:0065005)3.76647667
9somatic diversification of immune receptors via somatic mutation (GO:0002566)3.76378827
10somatic hypermutation of immunoglobulin genes (GO:0016446)3.76378827
11L-ascorbic acid metabolic process (GO:0019852)3.75467753
12DNA deamination (GO:0045006)3.70170344
13high-density lipoprotein particle remodeling (GO:0034375)3.67883167
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62723590
15L-fucose catabolic process (GO:0042355)3.60700351
16fucose catabolic process (GO:0019317)3.60700351
17L-fucose metabolic process (GO:0042354)3.60700351
18meiotic chromosome segregation (GO:0045132)3.54026256
19piRNA metabolic process (GO:0034587)3.40991562
20reverse cholesterol transport (GO:0043691)3.27827404
21regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.24271246
22protein neddylation (GO:0045116)3.17754056
23positive regulation of male gonad development (GO:2000020)3.17496446
24chromatin remodeling at centromere (GO:0031055)3.17093788
25regulation of non-canonical Wnt signaling pathway (GO:2000050)3.16253926
26protoporphyrinogen IX biosynthetic process (GO:0006782)3.15594877
27regulation of cholesterol esterification (GO:0010872)3.14772659
28plasma lipoprotein particle organization (GO:0071827)3.10646182
29low-density lipoprotein particle remodeling (GO:0034374)3.09972903
30cholesterol efflux (GO:0033344)3.06886778
31intestinal cholesterol absorption (GO:0030299)3.06187558
32CENP-A containing nucleosome assembly (GO:0034080)3.05704072
33DNA strand renaturation (GO:0000733)3.03704058
34protein-lipid complex remodeling (GO:0034368)3.01767275
35macromolecular complex remodeling (GO:0034367)3.01767275
36plasma lipoprotein particle remodeling (GO:0034369)3.01767275
37iron-sulfur cluster assembly (GO:0016226)2.98050290
38metallo-sulfur cluster assembly (GO:0031163)2.98050290
39behavioral response to nicotine (GO:0035095)2.97859505
40protoporphyrinogen IX metabolic process (GO:0046501)2.95790918
41indolalkylamine metabolic process (GO:0006586)2.94872836
42erythrocyte maturation (GO:0043249)2.90234853
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.88784191
44lung-associated mesenchyme development (GO:0060484)2.88497509
45histone exchange (GO:0043486)2.83597149
46male meiosis (GO:0007140)2.83190091
47estrogen biosynthetic process (GO:0006703)2.82737331
48mannosylation (GO:0097502)2.80819662
49porphyrin-containing compound biosynthetic process (GO:0006779)2.78571282
50C4-dicarboxylate transport (GO:0015740)2.77923485
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76452505
52regulation of male gonad development (GO:2000018)2.74663979
53response to follicle-stimulating hormone (GO:0032354)2.74399351
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.74372433
55protein-lipid complex subunit organization (GO:0071825)2.74205940
56tryptophan catabolic process (GO:0006569)2.70945969
57indole-containing compound catabolic process (GO:0042436)2.70945969
58indolalkylamine catabolic process (GO:0046218)2.70945969
59protein-cofactor linkage (GO:0018065)2.70181692
60tetrapyrrole biosynthetic process (GO:0033014)2.69593144
61tryptophan metabolic process (GO:0006568)2.68604213
62cell fate commitment involved in formation of primary germ layer (GO:0060795)2.66820336
63aromatic amino acid family catabolic process (GO:0009074)2.66710375
64proteasome assembly (GO:0043248)2.65348815
65negative regulation of DNA-dependent DNA replication (GO:2000104)2.62464970
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61945332
67L-phenylalanine catabolic process (GO:0006559)2.61945332
68centriole replication (GO:0007099)2.59696214
69sex differentiation (GO:0007548)2.58464727
70plasma lipoprotein particle clearance (GO:0034381)2.58222630
71protein prenylation (GO:0018342)2.56732632
72prenylation (GO:0097354)2.56732632
73DNA double-strand break processing (GO:0000729)2.56277399
74DNA methylation involved in gamete generation (GO:0043046)2.54726497
75cholesterol biosynthetic process (GO:0006695)2.54632297
76reciprocal DNA recombination (GO:0035825)2.53971174
77reciprocal meiotic recombination (GO:0007131)2.53971174
78positive regulation of hormone biosynthetic process (GO:0046886)2.52123470
79phospholipid efflux (GO:0033700)2.50750283
80ubiquinone metabolic process (GO:0006743)2.50660427
81porphyrin-containing compound metabolic process (GO:0006778)2.49596860
82regulation of mesoderm development (GO:2000380)2.48224770
83male meiosis I (GO:0007141)2.47551252
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.47167932
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.46709810
86heme transport (GO:0015886)2.45194013
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44947919
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44947919
89transepithelial transport (GO:0070633)2.44506187
90female gonad development (GO:0008585)2.44436834
91ribosomal small subunit assembly (GO:0000028)2.44139995
92water-soluble vitamin biosynthetic process (GO:0042364)2.42565522
93response to insecticide (GO:0017085)2.42493932
94cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.42280362
95platelet dense granule organization (GO:0060155)2.41912068
96negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40258955
97positive regulation of megakaryocyte differentiation (GO:0045654)2.39390969
98negative regulation of translation, ncRNA-mediated (GO:0040033)2.39358823
99regulation of translation, ncRNA-mediated (GO:0045974)2.39358823
100negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39358823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.07506642
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.03883598
3ZNF274_21170338_ChIP-Seq_K562_Hela3.89669296
4VDR_22108803_ChIP-Seq_LS180_Human3.24421929
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16945464
6IGF1R_20145208_ChIP-Seq_DFB_Human2.83418436
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.56207511
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.51801966
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48905640
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37904215
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.26960618
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10385797
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07958363
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07958363
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07958363
16IRF1_19129219_ChIP-ChIP_H3396_Human2.05069323
17E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94956873
18P300_19829295_ChIP-Seq_ESCs_Human1.94068977
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92484597
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87830799
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87259919
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84529803
23TAF15_26573619_Chip-Seq_HEK293_Human1.82203679
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76115922
25VDR_23849224_ChIP-Seq_CD4+_Human1.75273804
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70650065
27EWS_26573619_Chip-Seq_HEK293_Human1.69559243
28ELK1_19687146_ChIP-ChIP_HELA_Human1.69298719
29GBX2_23144817_ChIP-Seq_PC3_Human1.66014041
30NANOG_16153702_ChIP-ChIP_HESCs_Human1.64628440
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58766430
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.58652734
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.58218973
34E2F7_22180533_ChIP-Seq_HELA_Human1.54197123
35FOXP3_21729870_ChIP-Seq_TREG_Human1.54111596
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50765541
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47069720
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46475678
39FUS_26573619_Chip-Seq_HEK293_Human1.45846395
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45033143
41TP53_22573176_ChIP-Seq_HFKS_Human1.43344036
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42806124
43SOX2_19829295_ChIP-Seq_ESCs_Human1.42503433
44NANOG_19829295_ChIP-Seq_ESCs_Human1.42503433
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40672914
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38801505
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.38797706
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31526141
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29905166
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28313121
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.25900558
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22685957
53MYC_18940864_ChIP-ChIP_HL60_Human1.20801268
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.20620193
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20620193
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18941777
57CBP_20019798_ChIP-Seq_JUKART_Human1.18580913
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18580913
59BCAT_22108803_ChIP-Seq_LS180_Human1.17666608
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17662292
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16830086
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15157147
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14112951
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12473554
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12306819
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.11503695
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.10319213
68* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08298023
69AR_20517297_ChIP-Seq_VCAP_Human1.07853951
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07102076
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.07038379
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06280523
73TCF4_22108803_ChIP-Seq_LS180_Human1.06108945
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05976603
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.05556916
76RNF2_27304074_Chip-Seq_NSC_Mouse1.05496335
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05280885
78ER_23166858_ChIP-Seq_MCF-7_Human1.04656978
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04615786
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04245547
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03164682
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00976976
83CDX2_22108803_ChIP-Seq_LS180_Human0.99460603
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98895756
85SMAD4_21741376_ChIP-Seq_EPCs_Human0.98030286
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.97389738
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97111324
88HOXB7_26014856_ChIP-Seq_BT474_Human0.96556785
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95908140
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95172843
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94925134
92NCOR_22424771_ChIP-Seq_293T_Human0.93875173
93* TCF4_23295773_ChIP-Seq_U87_Human0.93072423
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92685016
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92255092
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92218602
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91812680
98AR_21572438_ChIP-Seq_LNCaP_Human0.91589916
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91512418
100MYC_18555785_ChIP-Seq_MESCs_Mouse0.91071477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.40260079
2MP0003195_calcinosis3.63851850
3MP0003878_abnormal_ear_physiology3.60603493
4MP0005377_hearing/vestibular/ear_phenot3.60603493
5MP0008877_abnormal_DNA_methylation3.29701477
6MP0004147_increased_porphyrin_level2.92268263
7MP0003567_abnormal_fetal_cardiomyocyte2.80724411
8MP0003890_abnormal_embryonic-extraembry2.59359247
9MP0003121_genomic_imprinting2.43541712
10MP0003136_yellow_coat_color2.43341125
11MP0004264_abnormal_extraembryonic_tissu2.23098187
12MP0001529_abnormal_vocalization2.19574786
13MP0003693_abnormal_embryo_hatching1.94171799
14MP0003941_abnormal_skin_development1.93045350
15MP0005083_abnormal_biliary_tract1.90465965
16MP0000372_irregular_coat_pigmentation1.88331001
17MP0005551_abnormal_eye_electrophysiolog1.86163254
18MP0002102_abnormal_ear_morphology1.86099023
19MP0003718_maternal_effect1.82478555
20MP0005365_abnormal_bile_salt1.79354597
21MP0002938_white_spotting1.75747027
22MP0004133_heterotaxia1.74047497
23MP0010329_abnormal_lipoprotein_level1.69549540
24MP0008995_early_reproductive_senescence1.69354231
25MP0006054_spinal_hemorrhage1.68607279
26MP0001293_anophthalmia1.63395813
27MP0006292_abnormal_olfactory_placode1.62277649
28MP0003119_abnormal_digestive_system1.61756239
29MP0003787_abnormal_imprinting1.56380422
30MP0005410_abnormal_fertilization1.55210988
31MP0008058_abnormal_DNA_repair1.51641159
32MP0008875_abnormal_xenobiotic_pharmacok1.48789318
33MP0006072_abnormal_retinal_apoptosis1.47810313
34MP0005085_abnormal_gallbladder_physiolo1.47056661
35MP0001485_abnormal_pinna_reflex1.43442721
36MP0004742_abnormal_vestibular_system1.42182315
37MP0003315_abnormal_perineum_morphology1.39000431
38MP0005394_taste/olfaction_phenotype1.37909800
39MP0005499_abnormal_olfactory_system1.37909800
40MP0004957_abnormal_blastocyst_morpholog1.34594235
41MP0005360_urolithiasis1.33014321
42MP0008789_abnormal_olfactory_epithelium1.31934771
43MP0001929_abnormal_gametogenesis1.31837331
44MP0001324_abnormal_eye_pigmentation1.31836927
45MP0005253_abnormal_eye_physiology1.31151661
46MP0001984_abnormal_olfaction1.29453681
47MP0003123_paternal_imprinting1.27807678
48MP0005084_abnormal_gallbladder_morpholo1.26209645
49MP0003011_delayed_dark_adaptation1.21512832
50MP0000647_abnormal_sebaceous_gland1.20952047
51MP0005646_abnormal_pituitary_gland1.20816470
52MP0003937_abnormal_limbs/digits/tail_de1.20706385
53MP0002254_reproductive_system_inflammat1.20198479
54MP0001666_abnormal_nutrient_absorption1.19687571
55MP0002210_abnormal_sex_determination1.19145073
56MP0000639_abnormal_adrenal_gland1.17781045
57MP0001764_abnormal_homeostasis1.17122318
58MP0000653_abnormal_sex_gland1.15728019
59MP0005636_abnormal_mineral_homeostasis1.12482195
60MP0003646_muscle_fatigue1.12372236
61MP0003698_abnormal_male_reproductive1.12309672
62MP0003111_abnormal_nucleus_morphology1.11769790
63MP0003186_abnormal_redox_activity1.09132161
64MP0000566_synostosis1.07793330
65MP0008872_abnormal_physiological_respon1.07101676
66MP0001145_abnormal_male_reproductive1.05751014
67MP0004019_abnormal_vitamin_homeostasis1.05368933
68MP0002736_abnormal_nociception_after1.04781293
69MP0002139_abnormal_hepatobiliary_system1.04636383
70MP0003656_abnormal_erythrocyte_physiolo1.03750202
71MP0001119_abnormal_female_reproductive1.01190102
72MP0006276_abnormal_autonomic_nervous0.99222012
73MP0002132_abnormal_respiratory_system0.93865749
74MP0004142_abnormal_muscle_tone0.91312583
75MP0010094_abnormal_chromosome_stability0.89577380
76MP0001286_abnormal_eye_development0.89321775
77MP0002653_abnormal_ependyma_morphology0.87784638
78MP0008057_abnormal_DNA_replication0.86879580
79MP0001986_abnormal_taste_sensitivity0.85390833
80MP0000383_abnormal_hair_follicle0.82370302
81MP0006035_abnormal_mitochondrial_morpho0.82173371
82MP0009672_abnormal_birth_weight0.81122880
83MP0005408_hypopigmentation0.78349543
84MP0005389_reproductive_system_phenotype0.77213572
85MP0002161_abnormal_fertility/fecundity0.75629156
86MP0001486_abnormal_startle_reflex0.75012186
87MP0009697_abnormal_copulation0.74582367
88MP0005332_abnormal_amino_acid0.73186649
89MP0001968_abnormal_touch/_nociception0.72953535
90MP0009046_muscle_twitch0.71761457
91MP0005391_vision/eye_phenotype0.71165272
92MP0005647_abnormal_sex_gland0.71039640
93MP0003252_abnormal_bile_duct0.68126368
94MP0010368_abnormal_lymphatic_system0.67394339
95MP0008932_abnormal_embryonic_tissue0.66941236
96MP0003077_abnormal_cell_cycle0.66385362
97MP0005187_abnormal_penis_morphology0.66297519
98MP0002160_abnormal_reproductive_system0.63733959
99MP0008004_abnormal_stomach_pH0.63454552
100MP0000516_abnormal_urinary_system0.63268841

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)3.81491785
2Hyperglycinuria (HP:0003108)3.71665080
3Acanthocytosis (HP:0001927)3.27386393
4Poikilocytosis (HP:0004447)3.16187459
5Prolonged partial thromboplastin time (HP:0003645)3.07871356
6Pancreatic islet-cell hyperplasia (HP:0004510)3.06658342
7Abnormality of serine family amino acid metabolism (HP:0010894)3.06124738
8Abnormality of glycine metabolism (HP:0010895)3.06124738
9Colon cancer (HP:0003003)2.83074508
10Abnormality of the heme biosynthetic pathway (HP:0010472)2.65117585
11Abnormal lung lobation (HP:0002101)2.64716552
12True hermaphroditism (HP:0010459)2.64053935
13Abolished electroretinogram (ERG) (HP:0000550)2.60886483
14Supernumerary spleens (HP:0009799)2.59798807
15Osteomalacia (HP:0002749)2.58597425
16Pancreatic cysts (HP:0001737)2.57391714
17Bilateral microphthalmos (HP:0007633)2.48340487
18Renal cortical cysts (HP:0000803)2.45481724
19Hypobetalipoproteinemia (HP:0003563)2.42994735
20Abnormality of the labia minora (HP:0012880)2.41231944
21Decreased central vision (HP:0007663)2.39728460
22Bifid tongue (HP:0010297)2.38257030
23Pendular nystagmus (HP:0012043)2.33699444
24Pancreatic fibrosis (HP:0100732)2.31263450
25Gonadal dysgenesis (HP:0000133)2.27812739
26Acute encephalopathy (HP:0006846)2.20483201
27Abnormality of serum amino acid levels (HP:0003112)2.17672565
28Meckel diverticulum (HP:0002245)2.14834557
29Nephroblastoma (Wilms tumor) (HP:0002667)2.11684496
30Attenuation of retinal blood vessels (HP:0007843)2.11489276
31Male pseudohermaphroditism (HP:0000037)2.09860495
32Anophthalmia (HP:0000528)2.08717269
33Abnormality of the ileum (HP:0001549)2.07370377
34Clitoromegaly (HP:0000057)2.07365836
35Spontaneous abortion (HP:0005268)2.05125533
36Abnormality of dental color (HP:0011073)2.03421995
37Embryonal renal neoplasm (HP:0011794)2.01664631
38Abnormal biliary tract physiology (HP:0012439)2.00820222
39Bile duct proliferation (HP:0001408)2.00820222
40Absent eyebrow (HP:0002223)2.00615945
41Abnormality of the renal cortex (HP:0011035)1.99805393
42Myelomeningocele (HP:0002475)1.99652949
43Abnormal number of erythroid precursors (HP:0012131)1.99115168
44Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98833696
45Chronic hepatic failure (HP:0100626)1.97324080
46Lissencephaly (HP:0001339)1.97128829
47Abnormality of methionine metabolism (HP:0010901)1.96518454
48Hypophosphatemic rickets (HP:0004912)1.92704015
49Molar tooth sign on MRI (HP:0002419)1.92175133
50Abnormality of midbrain morphology (HP:0002418)1.92175133
51Proximal tubulopathy (HP:0000114)1.91907254
52Hypothermia (HP:0002045)1.91382732
53Irregular epiphyses (HP:0010582)1.90985388
54Birth length less than 3rd percentile (HP:0003561)1.89767163
55Abnormality of the nasal septum (HP:0000419)1.89589523
56Acute necrotizing encephalopathy (HP:0006965)1.89048075
57Type II lissencephaly (HP:0007260)1.89040934
58Aplasia/Hypoplasia of the tibia (HP:0005772)1.88473385
59Methylmalonic aciduria (HP:0012120)1.86509855
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86327855
61Abnormality of alanine metabolism (HP:0010916)1.86327855
62Hyperalaninemia (HP:0003348)1.86327855
63Methylmalonic acidemia (HP:0002912)1.85617133
64Vaginal fistula (HP:0004320)1.84594597
65Enlarged kidneys (HP:0000105)1.83700749
66Stenosis of the external auditory canal (HP:0000402)1.83694515
67Neoplasm of the liver (HP:0002896)1.83184194
68Abnormality of the clitoris (HP:0000056)1.83032001
69Paralysis (HP:0003470)1.81767397
70Deep venous thrombosis (HP:0002625)1.80294897
71Abnormality of the pubic bones (HP:0003172)1.79384892
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79356741
73Female pseudohermaphroditism (HP:0010458)1.78289253
74Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77495773
75Short tibia (HP:0005736)1.75888363
76Bicornuate uterus (HP:0000813)1.74310431
77Vaginal atresia (HP:0000148)1.73928055
78Cupped ear (HP:0000378)1.73624565
79Broad alveolar ridges (HP:0000187)1.72545961
80Type I transferrin isoform profile (HP:0003642)1.71749034
81Rectovaginal fistula (HP:0000143)1.70651076
82Rectal fistula (HP:0100590)1.70651076
83Genital tract atresia (HP:0001827)1.69381745
84Hypomagnesemia (HP:0002917)1.68916761
85Increased CSF lactate (HP:0002490)1.67906359
86Hypochromic microcytic anemia (HP:0004840)1.64794828
87Chromsome breakage (HP:0040012)1.63523175
88Abnormality of urine glucose concentration (HP:0011016)1.63408180
89Glycosuria (HP:0003076)1.63408180
90Hepatoblastoma (HP:0002884)1.63085409
91Hypolipoproteinemia (HP:0010981)1.61996311
92Joint hemorrhage (HP:0005261)1.61900267
93Hypoplasia of the pons (HP:0012110)1.57809349
94Hypoplasia of the uterus (HP:0000013)1.57769168
95Scrotal hypoplasia (HP:0000046)1.55480415
96Abnormal mitochondria in muscle tissue (HP:0008316)1.55185092
97Horseshoe kidney (HP:0000085)1.55108912
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.54149205
99Hypoglycemic coma (HP:0001325)1.53973167
100Abnormality of endocrine pancreas physiology (HP:0012093)1.53578690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.59080166
2LATS13.56643229
3INSRR3.33379806
4WNK42.73616846
5BMPR1B2.61594372
6ACVR1B2.61108515
7WNK32.53220801
8FRK2.31268695
9VRK22.13665142
10NUAK12.09480824
11STK38L1.99868266
12TNIK1.97397208
13PLK41.95312713
14OXSR11.91825781
15TXK1.88329591
16STK391.87293055
17TAF11.66394751
18NME11.63810755
19SRPK11.63251183
20VRK11.62155692
21PLK31.61882426
22CDK191.60085170
23ADRBK21.58545130
24GRK11.56832025
25TRIM281.52857796
26EIF2AK31.50658533
27MAP4K21.45032318
28PINK11.41662707
29BCKDK1.34490559
30MST41.32533986
31DYRK21.31755489
32TTK1.28633965
33MKNK21.25164579
34EIF2AK11.24941488
35KDR1.21819995
36BRSK21.18841301
37TIE11.15786357
38MAP3K41.14046681
39BUB11.12043132
40STK31.08399632
41MATK1.07493482
42MKNK11.04208914
43FGR0.99906702
44NEK20.99475170
45WEE10.97761111
46STK160.97176741
47PLK10.96620307
48DYRK30.94215981
49TAOK30.90738093
50PIK3CA0.87044797
51LATS20.86647259
52BCR0.85764060
53PASK0.84768989
54CAMK1D0.84056117
55TYRO30.83627819
56MAP3K90.80650014
57PLK20.80407274
58CSNK1G10.78529464
59TLK10.72788132
60AKT30.65021873
61CSNK1G20.64234450
62FGFR10.63948673
63NLK0.63834207
64TSSK60.62368613
65CSNK1G30.61978492
66PIM10.59822224
67CSNK1A1L0.59452324
68MAPK130.58627865
69CAMK1G0.58145872
70MAP3K120.51993435
71TEC0.51222925
72PRKCG0.50844462
73RPS6KA50.50800411
74PRKCQ0.50639903
75CHEK20.49920442
76RPS6KA40.48906837
77ADRBK10.48544538
78PDK20.47509449
79CSNK2A10.46809553
80ITK0.46039451
81CSNK1D0.45311610
82ATM0.43243375
83ERBB20.42944952
84CDC70.42152999
85PNCK0.41552428
86CLK10.41551610
87MAP2K70.41290033
88BRSK10.40356503
89CSNK2A20.39126597
90TESK20.38278551
91PIK3CG0.37995937
92NEK10.37906446
93ATR0.37902290
94TGFBR10.37805857
95CSNK1A10.37274667
96CDK70.33656422
97PRKAA20.33384643
98PRKACA0.33182341
99PBK0.32285456
100DYRK1A0.31346028

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.30987230
2Propanoate metabolism_Homo sapiens_hsa006402.60551013
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30591707
4Mismatch repair_Homo sapiens_hsa034302.23707591
5Proteasome_Homo sapiens_hsa030502.22781529
6Protein export_Homo sapiens_hsa030602.12668905
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.11234119
8Vitamin digestion and absorption_Homo sapiens_hsa049772.06772441
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94035284
10One carbon pool by folate_Homo sapiens_hsa006701.92680792
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89814251
12Fat digestion and absorption_Homo sapiens_hsa049751.83232182
13Selenocompound metabolism_Homo sapiens_hsa004501.82652232
14Homologous recombination_Homo sapiens_hsa034401.82182962
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78883151
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76737867
17Oxidative phosphorylation_Homo sapiens_hsa001901.74392692
18RNA polymerase_Homo sapiens_hsa030201.71236371
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71183146
20Nitrogen metabolism_Homo sapiens_hsa009101.70537563
21RNA degradation_Homo sapiens_hsa030181.70241259
22Butanoate metabolism_Homo sapiens_hsa006501.69628592
23Complement and coagulation cascades_Homo sapiens_hsa046101.69531505
24Basal transcription factors_Homo sapiens_hsa030221.68214613
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65530774
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63984787
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63888159
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58340909
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54245541
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.52922423
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49859328
32Fanconi anemia pathway_Homo sapiens_hsa034601.49105441
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45825769
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41800662
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.39967183
36Peroxisome_Homo sapiens_hsa041461.36974821
37Parkinsons disease_Homo sapiens_hsa050121.32037645
38Non-homologous end-joining_Homo sapiens_hsa034501.31805493
39ABC transporters_Homo sapiens_hsa020101.30889281
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.25257908
41Phototransduction_Homo sapiens_hsa047441.23019684
42RNA transport_Homo sapiens_hsa030131.21672138
43Fatty acid metabolism_Homo sapiens_hsa012121.21373827
44Tryptophan metabolism_Homo sapiens_hsa003801.20684063
45Fatty acid elongation_Homo sapiens_hsa000621.17266465
46Ribosome_Homo sapiens_hsa030101.16414791
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.13092265
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09931577
49Fatty acid degradation_Homo sapiens_hsa000711.07917571
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05997164
51Fatty acid biosynthesis_Homo sapiens_hsa000611.05282920
52DNA replication_Homo sapiens_hsa030301.05131431
53Linoleic acid metabolism_Homo sapiens_hsa005911.04851026
54Base excision repair_Homo sapiens_hsa034101.04034838
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03288466
56Chemical carcinogenesis_Homo sapiens_hsa052041.02040713
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01685739
58Retinol metabolism_Homo sapiens_hsa008300.99980651
59Pyruvate metabolism_Homo sapiens_hsa006200.93519753
60Ether lipid metabolism_Homo sapiens_hsa005650.92170667
61Huntingtons disease_Homo sapiens_hsa050160.90818804
62Nucleotide excision repair_Homo sapiens_hsa034200.89761864
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88281873
64Metabolic pathways_Homo sapiens_hsa011000.85341926
65Spliceosome_Homo sapiens_hsa030400.83125116
66Basal cell carcinoma_Homo sapiens_hsa052170.80693254
67Cell cycle_Homo sapiens_hsa041100.79757151
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77028260
69Collecting duct acid secretion_Homo sapiens_hsa049660.71605175
70N-Glycan biosynthesis_Homo sapiens_hsa005100.71590731
71Purine metabolism_Homo sapiens_hsa002300.69865789
72Hedgehog signaling pathway_Homo sapiens_hsa043400.67952433
73Histidine metabolism_Homo sapiens_hsa003400.67612478
74Nicotine addiction_Homo sapiens_hsa050330.67377583
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67319743
76Glutathione metabolism_Homo sapiens_hsa004800.63571427
77Arginine and proline metabolism_Homo sapiens_hsa003300.63329306
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62530475
79mRNA surveillance pathway_Homo sapiens_hsa030150.61786855
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61692850
81Primary immunodeficiency_Homo sapiens_hsa053400.60955208
82Regulation of autophagy_Homo sapiens_hsa041400.60832073
83TGF-beta signaling pathway_Homo sapiens_hsa043500.59358492
84beta-Alanine metabolism_Homo sapiens_hsa004100.58536234
85Caffeine metabolism_Homo sapiens_hsa002320.56485832
86PPAR signaling pathway_Homo sapiens_hsa033200.54603290
87Pyrimidine metabolism_Homo sapiens_hsa002400.53902809
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53397360
89Ovarian steroidogenesis_Homo sapiens_hsa049130.52413136
90Starch and sucrose metabolism_Homo sapiens_hsa005000.52015750
91Mineral absorption_Homo sapiens_hsa049780.50762222
92Alzheimers disease_Homo sapiens_hsa050100.50725755
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50677918
94Systemic lupus erythematosus_Homo sapiens_hsa053220.50645987
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48843796
96Olfactory transduction_Homo sapiens_hsa047400.46201952
97p53 signaling pathway_Homo sapiens_hsa041150.42772600
98Folate biosynthesis_Homo sapiens_hsa007900.42061025
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39399665
100Glycerolipid metabolism_Homo sapiens_hsa005610.38587985

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