SLC29A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.78354422
2positive regulation by symbiont of host defense response (GO:0052509)5.48914277
3modulation by symbiont of host defense response (GO:0052031)5.48914277
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.48914277
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.48914277
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.48914277
7modulation by symbiont of host immune response (GO:0052553)5.48914277
8amino sugar catabolic process (GO:0046348)5.35232997
9axon ensheathment in central nervous system (GO:0032291)5.31232265
10central nervous system myelination (GO:0022010)5.31232265
11microglial cell activation (GO:0001774)5.21437635
12regulation of interferon-beta biosynthetic process (GO:0045357)4.79366604
13neutrophil activation involved in immune response (GO:0002283)4.73294080
14macrophage activation involved in immune response (GO:0002281)4.55276283
15N-acetylneuraminate metabolic process (GO:0006054)4.19415741
16sphingolipid catabolic process (GO:0030149)4.03072945
17membrane lipid catabolic process (GO:0046466)3.99087099
18cellular response to thyroid hormone stimulus (GO:0097067)3.98230964
19pinocytosis (GO:0006907)3.95184862
20regulation of superoxide anion generation (GO:0032928)3.88021170
21response to thyroid hormone (GO:0097066)3.85077649
22response to lipoprotein particle (GO:0055094)3.72381875
23axon ensheathment (GO:0008366)3.70862835
24ensheathment of neurons (GO:0007272)3.70862835
25positive regulation of mast cell degranulation (GO:0043306)3.67758626
26positive regulation of mast cell activation involved in immune response (GO:0033008)3.67758626
27myelination (GO:0042552)3.66144820
28regulation of cholesterol esterification (GO:0010872)3.61221023
29fat-soluble vitamin biosynthetic process (GO:0042362)3.60051355
30negative regulation of interleukin-12 production (GO:0032695)3.56740067
31positive regulation of mast cell activation (GO:0033005)3.56119192
32positive regulation of toll-like receptor signaling pathway (GO:0034123)3.54907651
33regulation of B cell receptor signaling pathway (GO:0050855)3.54773655
34respiratory burst (GO:0045730)3.54044297
35positive regulation of chemokine secretion (GO:0090197)3.53292978
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51335349
37response to host immune response (GO:0052572)3.51335349
38amyloid precursor protein catabolic process (GO:0042987)3.51291780
39positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.47225004
40barbed-end actin filament capping (GO:0051016)3.46398205
41positive regulation of antigen processing and presentation (GO:0002579)3.46333371
42positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.45336248
43L-amino acid import (GO:0043092)3.44327225
44macrophage activation (GO:0042116)3.42493470
45import into cell (GO:0098657)3.41744657
46positive regulation of interferon-alpha production (GO:0032727)3.41108996
47neutrophil activation (GO:0042119)3.40001133
48B cell mediated immunity (GO:0019724)3.39501599
49regulation of mast cell activation involved in immune response (GO:0033006)3.36518208
50myeloid cell activation involved in immune response (GO:0002275)3.34874920
51G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.31610265
52regulation of cholesterol storage (GO:0010885)3.30808859
53regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27808681
54regulation of leukocyte degranulation (GO:0043300)3.26687416
55positive regulation of monocyte chemotaxis (GO:0090026)3.26175443
56response to host defenses (GO:0052200)3.26116503
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26116503
58response to host (GO:0075136)3.26116503
59regulation of interferon-alpha production (GO:0032647)3.23305759
60granulocyte activation (GO:0036230)3.21667913
61glucosamine-containing compound catabolic process (GO:1901072)3.20857942
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19304991
63virion attachment to host cell (GO:0019062)3.14256185
64adhesion of symbiont to host cell (GO:0044650)3.14256185
65positive regulation of bone resorption (GO:0045780)3.13533800
66positive regulation of bone remodeling (GO:0046852)3.13533800
67leukocyte aggregation (GO:0070486)3.08070479
68positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.05199955
69activated T cell proliferation (GO:0050798)3.05040890
70phagosome maturation (GO:0090382)3.05020845
71cellular extravasation (GO:0045123)3.04257159
72negative regulation of B cell proliferation (GO:0030889)3.02506778
73negative regulation of myeloid cell apoptotic process (GO:0033033)3.01069466
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.00461768
75amyloid precursor protein metabolic process (GO:0042982)2.99694012
76regulation of antigen processing and presentation (GO:0002577)2.99558692
77phospholipid efflux (GO:0033700)2.97875467
78pH reduction (GO:0045851)2.97207279
79phagocytosis, engulfment (GO:0006911)2.97142124
80positive regulation of lipoprotein lipase activity (GO:0051006)2.96960305
81positive regulation of triglyceride lipase activity (GO:0061365)2.96960305
82fatty acid elongation (GO:0030497)2.96614810
83negative regulation of neurotransmitter secretion (GO:0046929)2.91036784
84lipoxygenase pathway (GO:0019372)2.88573315
85glycosphingolipid catabolic process (GO:0046479)2.87493181
86positive regulation of B cell differentiation (GO:0045579)2.86512932
87regulation of hypersensitivity (GO:0002883)2.85984928
88lysosome organization (GO:0007040)2.85586328
89lytic vacuole organization (GO:0080171)2.85586328
90regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85454192
91immunoglobulin mediated immune response (GO:0016064)2.84507744
92intracellular pH reduction (GO:0051452)2.84195486
93positive regulation of interleukin-17 production (GO:0032740)2.83048499
94glycosylceramide metabolic process (GO:0006677)2.82950865
95positive regulation of cellular amide metabolic process (GO:0034250)2.82819631
96regulation of mast cell activation (GO:0033003)2.81865410
97response to cholesterol (GO:0070723)2.81523018
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80850846
99pentose metabolic process (GO:0019321)2.80830507
100leukocyte migration involved in inflammatory response (GO:0002523)2.80256190
101apoptotic cell clearance (GO:0043277)2.79542311
102keratan sulfate catabolic process (GO:0042340)2.78550543
103response to muramyl dipeptide (GO:0032495)2.78163449
104B cell receptor signaling pathway (GO:0050853)2.77565849
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76484994
106plasma lipoprotein particle clearance (GO:0034381)2.74776243
107I-kappaB phosphorylation (GO:0007252)2.73490570
108amino acid import (GO:0043090)2.72667559
109very-low-density lipoprotein particle assembly (GO:0034379)2.69745383
110negative regulation of nitric oxide biosynthetic process (GO:0045019)2.69301188
111regulation of chemokine secretion (GO:0090196)2.69239115
112positive regulation of gamma-delta T cell activation (GO:0046645)2.68948796
113myeloid leukocyte activation (GO:0002274)2.67174900
114purine nucleotide salvage (GO:0032261)2.64936264
115oligosaccharide catabolic process (GO:0009313)2.64682121
116myeloid dendritic cell differentiation (GO:0043011)2.64277162
117regulation of superoxide metabolic process (GO:0090322)2.63802911
118antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.63781318
119cholesterol efflux (GO:0033344)2.63598093
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63427737
121G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.63151289
122response to laminar fluid shear stress (GO:0034616)2.61677724
123cortical actin cytoskeleton organization (GO:0030866)2.61572954
124positive regulation of tissue remodeling (GO:0034105)2.61509075
125creatine metabolic process (GO:0006600)2.61473204
126glycolipid catabolic process (GO:0019377)2.61429358
127plasma lipoprotein particle assembly (GO:0034377)2.59957523
128mast cell activation (GO:0045576)2.59116106
129myeloid dendritic cell activation (GO:0001773)2.58391193
130regulation of interleukin-17 production (GO:0032660)2.58225235
131myelin maintenance (GO:0043217)2.57884753
132long-chain fatty acid biosynthetic process (GO:0042759)2.57715984
133protein maturation by protein folding (GO:0022417)2.57308133
134membrane protein intracellular domain proteolysis (GO:0031293)2.57122939
135purine deoxyribonucleotide catabolic process (GO:0009155)2.56606158
136response to peptidoglycan (GO:0032494)2.55726360
137energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.53815600
138ATP hydrolysis coupled proton transport (GO:0015991)2.53815600
139regulation of mononuclear cell migration (GO:0071675)2.53537069
140regulation of mast cell degranulation (GO:0043304)2.53301956
141peptide catabolic process (GO:0043171)2.53110271
142macrophage differentiation (GO:0030225)2.52838506
143purinergic nucleotide receptor signaling pathway (GO:0035590)2.52805886
144NADPH regeneration (GO:0006740)2.52591135
145B cell homeostasis (GO:0001782)2.52205675
146positive regulation of regulated secretory pathway (GO:1903307)2.51980338
147regulation of interferon-gamma biosynthetic process (GO:0045072)2.51434859
148lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50672297
149serine transport (GO:0032329)2.50241976
150negative regulation of granulocyte differentiation (GO:0030853)2.50233147
151monocyte chemotaxis (GO:0002548)2.49940781
152regulation of regulated secretory pathway (GO:1903305)2.49829846
153regulation of monocyte differentiation (GO:0045655)2.49305472
154pentose-phosphate shunt (GO:0006098)2.49079663
155positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48522680
156tolerance induction (GO:0002507)2.48367114
157cortical cytoskeleton organization (GO:0030865)2.48023357
158pyrimidine-containing compound salvage (GO:0008655)2.47869305
159pyrimidine nucleoside salvage (GO:0043097)2.47869305
160pathway-restricted SMAD protein phosphorylation (GO:0060389)2.45585796
161cyclooxygenase pathway (GO:0019371)2.44301244
162positive regulation of smooth muscle cell migration (GO:0014911)2.43842955
163positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.43726789
164adhesion of symbiont to host (GO:0044406)2.43605719
165hyaluronan catabolic process (GO:0030214)2.42543932
166positive regulation of leukocyte degranulation (GO:0043302)2.42373876
167positive regulation of interferon-beta production (GO:0032728)2.41583589
168ceramide catabolic process (GO:0046514)2.41580138
169germinal center formation (GO:0002467)2.41232320
170regulation of macrophage chemotaxis (GO:0010758)2.41187657
171protein-lipid complex assembly (GO:0065005)2.40902350
172regulation of B cell differentiation (GO:0045577)2.40354222
173transferrin transport (GO:0033572)2.39868677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.30401259
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06140673
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.78241148
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.25299637
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.21790759
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.74798756
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.29672662
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19796608
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.02062039
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71321191
11RUNX_20019798_ChIP-Seq_JUKART_Human2.67989343
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59946113
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59299145
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54358035
15SCL_19346495_ChIP-Seq_HPC-7_Human2.51449562
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50437306
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25741738
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14890903
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14534456
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12827949
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11529289
22VDR_24787735_ChIP-Seq_THP-1_Human2.09273212
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06528362
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99754040
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98685708
26NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.97171161
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96972494
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96311577
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95923830
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91740899
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90722917
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.83134331
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77319995
34SPI1_23127762_ChIP-Seq_K562_Human1.73582813
35LXR_22292898_ChIP-Seq_THP-1_Human1.72825579
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72334924
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72024497
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70223333
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69951600
40VDR_24763502_ChIP-Seq_THP-1_Human1.69587957
41TFEB_21752829_ChIP-Seq_HELA_Human1.69070635
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68547592
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67586732
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63404553
45E2F7_22180533_ChIP-Seq_HELA_Human1.61832524
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58740030
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57260932
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56171929
49SPI1_23547873_ChIP-Seq_NB4_Human1.55916114
50* PU_27001747_Chip-Seq_BMDM_Mouse1.55266666
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54870018
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54638020
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50886095
54MYB_26560356_Chip-Seq_TH2_Human1.50124167
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47310883
56MYC_22102868_ChIP-Seq_BL_Human1.46317896
57ZNF263_19887448_ChIP-Seq_K562_Human1.42359047
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.40907706
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.40429955
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.40263933
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39972006
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37288957
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35806683
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.34500684
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32245093
66BCL6_27268052_Chip-Seq_Bcells_Human1.31251658
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30256916
68* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30085207
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29430181
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29031043
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28316634
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.27507834
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24834710
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24276481
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24178711
76GATA3_27048872_Chip-Seq_THYMUS_Human1.24162595
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23799305
78VDR_21846776_ChIP-Seq_THP-1_Human1.23652041
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.23142758
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.21689100
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21021918
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20298190
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20098371
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19892415
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19500370
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19425644
87* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18893935
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.17096833
89* SRF_21415370_ChIP-Seq_HL-1_Mouse1.17062708
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.16729214
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.16724907
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16670001
93RXR_22158963_ChIP-Seq_LIVER_Mouse1.15811428
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15669250
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15605354
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14544674
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.14355866
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14013365
99MAF_26560356_Chip-Seq_TH1_Human1.13710218
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13559498
101BCOR_27268052_Chip-Seq_Bcells_Human1.13302194
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13280637
103GABP_19822575_ChIP-Seq_HepG2_Human1.12795183
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.12754711
105* FOXO3_23340844_ChIP-Seq_DLD1_Human1.11757774
106MYB_26560356_Chip-Seq_TH1_Human1.11256798
107* TET1_21451524_ChIP-Seq_MESCs_Mouse1.09978369
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09716011
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08435249
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08126268
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08112561
112* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06533904
113* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05201687
114RACK7_27058665_Chip-Seq_MCF-7_Human1.05130916
115* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04999215
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04805720
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04770570
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04752597
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04568448
120* CJUN_26792858_Chip-Seq_BT549_Human1.03880101
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02486309
122GATA3_26560356_Chip-Seq_TH2_Human1.02238910
123* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01496005
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00998269
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00942289
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00649918
127* NCOR1_26117541_ChIP-Seq_K562_Human1.00601006
128DCP1A_22483619_ChIP-Seq_HELA_Human1.00525489
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00324112
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99808724
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97156909
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97156909
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97109732
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96382279
135GATA2_19941826_ChIP-Seq_K562_Human0.96327398
136GATA1_19941826_ChIP-Seq_K562_Human0.95228636
137* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94635951
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91198667
139LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88375265
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86750664
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85636179
142* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85506742
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.84953826
144TP53_16413492_ChIP-PET_HCT116_Human0.84295243
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84123011
146SOX2_20726797_ChIP-Seq_SW620_Human0.82306535
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82153196
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80743035
149ER_23166858_ChIP-Seq_MCF-7_Human0.80524978
150JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80085769
151* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79467313
152GBX2_23144817_ChIP-Seq_PC3_Human0.77597009
153AR_21572438_ChIP-Seq_LNCaP_Human0.75950172
154P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75477605
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75226485
156TCF7_22412390_ChIP-Seq_EML_Mouse0.74619169
157* SMRT_27268052_Chip-Seq_Bcells_Human0.74186468
158UTX_26944678_Chip-Seq_JUKART_Human0.73917175
159STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73185290
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.73127481
161KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72698835
162AHR_22903824_ChIP-Seq_MCF-7_Human0.72290725
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71548841
164PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71452987
165TRIM28_21343339_ChIP-Seq_HEK293_Human0.70902848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.45065799
2MP0006082_CNS_inflammation3.83275336
3MP0000920_abnormal_myelination3.56084021
4MP0002139_abnormal_hepatobiliary_system3.42995924
5MP0003806_abnormal_nucleotide_metabolis3.40205800
6MP0001835_abnormal_antigen_presentation3.35351129
7MP0003690_abnormal_glial_cell3.31933229
8MP0005671_abnormal_response_to2.92455409
9MP0003172_abnormal_lysosome_physiology2.87632728
10MP0002419_abnormal_innate_immunity2.75466269
11MP0003191_abnormal_cellular_cholesterol2.70372142
12MP0005000_abnormal_immune_tolerance2.60851733
13MP0003303_peritoneal_inflammation2.57271333
14MP0003436_decreased_susceptibility_to2.51359663
15MP0002148_abnormal_hypersensitivity_rea2.50891138
16MP0001790_abnormal_immune_system2.43281534
17MP0005387_immune_system_phenotype2.43281534
18MP0002452_abnormal_antigen_presenting2.37609578
19MP0001851_eye_inflammation2.27422495
20MP0001800_abnormal_humoral_immune2.22302222
21MP0002723_abnormal_immune_serum2.19461416
22MP0005365_abnormal_bile_salt2.19243043
23MP0005025_abnormal_response_to2.16097159
24MP0001819_abnormal_immune_cell1.94691987
25MP0000685_abnormal_immune_system1.94287793
26MP0002420_abnormal_adaptive_immunity1.94005494
27MP0005464_abnormal_platelet_physiology1.93133845
28MP0001533_abnormal_skeleton_physiology1.91873091
29MP0003300_gastrointestinal_ulcer1.83168563
30MP0003950_abnormal_plasma_membrane1.82425521
31MP0005310_abnormal_salivary_gland1.81741880
32MP0003724_increased_susceptibility_to1.76359165
33MP0009840_abnormal_foam_cell1.75661693
34MP0009785_altered_susceptibility_to1.73989678
35MP0002933_joint_inflammation1.72819690
36MP0002998_abnormal_bone_remodeling1.69578189
37MP0003075_altered_response_to1.60130664
38MP0000604_amyloidosis1.53766607
39MP0003634_abnormal_glial_cell1.53722938
40MP0002405_respiratory_system_inflammati1.52406096
41MP0002396_abnormal_hematopoietic_system1.49655281
42MP0000465_gastrointestinal_hemorrhage1.47739391
43MP0000716_abnormal_immune_system1.47472220
44MP0004510_myositis1.44531573
45MP0000858_altered_metastatic_potential1.42959053
46MP0003186_abnormal_redox_activity1.41681922
47MP0000343_altered_response_to1.41627967
48MP0001845_abnormal_inflammatory_respons1.41461161
49MP0004947_skin_inflammation1.39635003
50MP0008438_abnormal_cutaneous_collagen1.38103677
51MP0005397_hematopoietic_system_phenotyp1.37458161
52MP0001545_abnormal_hematopoietic_system1.37458161
53MP0001853_heart_inflammation1.32924924
54MP0004742_abnormal_vestibular_system1.27796082
55MP0009333_abnormal_splenocyte_physiolog1.24822083
56MP0002398_abnormal_bone_marrow1.22778555
57MP0008875_abnormal_xenobiotic_pharmacok1.22430568
58MP0000689_abnormal_spleen_morphology1.19801283
59MP0004019_abnormal_vitamin_homeostasis1.19746923
60MP0008469_abnormal_protein_level1.17535523
61MP0004185_abnormal_adipocyte_glucose1.15619193
62MP0003045_fibrosis1.14049857
63MP0005257_abnormal_intraocular_pressure1.13493343
64MP0005451_abnormal_body_composition1.12817129
65MP0005319_abnormal_enzyme/_coenzyme1.10200438
66MP0001764_abnormal_homeostasis1.09379698
67MP0002429_abnormal_blood_cell1.08946704
68MP0003448_altered_tumor_morphology1.08370279
69MP0000383_abnormal_hair_follicle1.06931694
70MP0004885_abnormal_endolymph1.06705541
71MP0003656_abnormal_erythrocyte_physiolo1.06698667
72MP0001958_emphysema1.04244806
73MP0010155_abnormal_intestine_physiology1.03793192
74MP0001849_ear_inflammation1.03261205
75MP0001873_stomach_inflammation1.01563973
76MP0003136_yellow_coat_color1.00528414
77MP0005390_skeleton_phenotype0.99613421
78MP0005166_decreased_susceptibility_to0.99476418
79MP0002722_abnormal_immune_system0.99449040
80MP0002166_altered_tumor_susceptibility0.97939179
81MP0003183_abnormal_peptide_metabolism0.96919705
82MP0009278_abnormal_bone_marrow0.93709323
83MP0003195_calcinosis0.91282870
84MP0002090_abnormal_vision0.91272941
85MP0005647_abnormal_sex_gland0.91068248
86MP0000609_abnormal_liver_physiology0.89099185
87MP0000371_diluted_coat_color0.88974235
88MP0000569_abnormal_digit_pigmentation0.88251393
89MP0010678_abnormal_skin_adnexa0.87699802
90MP0003795_abnormal_bone_structure0.86572760
91MP0000490_abnormal_crypts_of0.86284316
92MP0006054_spinal_hemorrhage0.84824610
93MP0002136_abnormal_kidney_physiology0.84271094
94MP0006036_abnormal_mitochondrial_physio0.84140313
95MP0005409_darkened_coat_color0.84054696
96MP0004233_abnormal_muscle_weight0.83856556
97MP0005171_absent_coat_pigmentation0.83814798
98MP0002132_abnormal_respiratory_system0.83690444
99MP0002254_reproductive_system_inflammat0.83478326
100MP0002877_abnormal_melanocyte_morpholog0.83176592
101MP0005584_abnormal_enzyme/coenzyme_acti0.82742017
102MP0005377_hearing/vestibular/ear_phenot0.80520978
103MP0003878_abnormal_ear_physiology0.80520978
104MP0005167_abnormal_blood-brain_barrier0.79453504
105MP0008004_abnormal_stomach_pH0.78647736
106MP0005164_abnormal_response_to0.78561002
107MP0009764_decreased_sensitivity_to0.77744229
108MP0003453_abnormal_keratinocyte_physiol0.77726760
109MP0010307_abnormal_tumor_latency0.76715127
110MP0000767_abnormal_smooth_muscle0.75601773
111MP0009763_increased_sensitivity_to0.75475786
112MP0003633_abnormal_nervous_system0.75325032
113MP0005085_abnormal_gallbladder_physiolo0.74486861
114MP0000249_abnormal_blood_vessel0.74467671
115MP0003279_aneurysm0.72571973
116MP0002006_tumorigenesis0.72272352
117MP0003329_amyloid_beta_deposits0.72248701
118MP0002277_abnormal_respiratory_mucosa0.71930375
119MP0003828_pulmonary_edema0.71910677
120MP0000681_abnormal_thyroid_gland0.71870982
121MP0001666_abnormal_nutrient_absorption0.70956547
122MP0005174_abnormal_tail_pigmentation0.70396212
123MP0003693_abnormal_embryo_hatching0.70178219
124MP0003718_maternal_effect0.70146485
125MP0004134_abnormal_chest_morphology0.70016229
126MP0003091_abnormal_cell_migration0.69672738
127MP0005360_urolithiasis0.68483474
128MP0008260_abnormal_autophagy0.68310173
129MP0010329_abnormal_lipoprotein_level0.67082754
130MP0000733_abnormal_muscle_development0.66655224
131MP0000358_abnormal_cell_content/0.65703991
132MP0005666_abnormal_adipose_tissue0.65571138
133MP0005165_increased_susceptibility_to0.65437600
134MP0003632_abnormal_nervous_system0.65411142
135MP0004381_abnormal_hair_follicle0.65046334
136MP0000313_abnormal_cell_death0.64220112
137MP0002229_neurodegeneration0.63685746
138MP0002168_other_aberrant_phenotype0.62699319
139MP0005410_abnormal_fertilization0.62269403

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.48670668
2Recurrent abscess formation (HP:0002722)5.42310436
3Increased neuronal autofluorescent lipopigment (HP:0002074)5.25346179
4Systemic lupus erythematosus (HP:0002725)5.08382280
5Recurrent bacterial skin infections (HP:0005406)5.05501675
6Abnormality of liposaccharide metabolism (HP:0010968)5.05007886
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.05007886
8Abnormality of glycolipid metabolism (HP:0010969)5.05007886
9Vacuolated lymphocytes (HP:0001922)5.02869972
10Eczematoid dermatitis (HP:0000976)4.58375819
11Abnormality of macrophages (HP:0004311)4.44236662
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.42723724
13Axonal loss (HP:0003447)4.16310460
14Dysostosis multiplex (HP:0000943)4.05480728
15Neurofibrillary tangles (HP:0002185)3.95886966
16Glomerulonephritis (HP:0000099)3.75802479
17Recurrent skin infections (HP:0001581)3.63541916
18Petechiae (HP:0000967)3.60705432
19Disinhibition (HP:0000734)3.53719440
20Arterial tortuosity (HP:0005116)3.44307071
21Hepatosplenomegaly (HP:0001433)3.33238580
22Vascular tortuosity (HP:0004948)3.03067108
23Recurrent gram-negative bacterial infections (HP:0005420)3.02898750
24Loss of speech (HP:0002371)2.98864919
25Multiple enchondromatosis (HP:0005701)2.98168551
26Diminished motivation (HP:0000745)2.93931039
27Urinary glycosaminoglycan excretion (HP:0003541)2.92392844
28Mucopolysacchariduria (HP:0008155)2.92392844
29Upper motor neuron abnormality (HP:0002127)2.89004028
30Apathy (HP:0000741)2.85848362
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.84404500
32Abnormality of polysaccharide metabolism (HP:0011012)2.84404500
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.84404500
34Increased serum ferritin (HP:0003281)2.71478871
35Recurrent fungal infections (HP:0002841)2.71408002
36Chronic obstructive pulmonary disease (HP:0006510)2.69871185
37Obstructive lung disease (HP:0006536)2.69871185
38Segmental peripheral demyelination/remyelination (HP:0003481)2.67106652
39Peripheral demyelination (HP:0011096)2.61219482
40Autoimmune thrombocytopenia (HP:0001973)2.60569065
41Disproportionate tall stature (HP:0001519)2.60306171
42Cerebral inclusion bodies (HP:0100314)2.58825222
43Metabolic alkalosis (HP:0200114)2.57683581
44Thick nail (HP:0001805)2.56953102
45Chronic diarrhea (HP:0002028)2.56304591
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.54647975
47Osteolytic defects of the hand bones (HP:0009699)2.54647975
48Hypertensive crisis (HP:0100735)2.52721649
49Nuclear cataract (HP:0100018)2.52230035
50Clumsiness (HP:0002312)2.51717445
51Stomatitis (HP:0010280)2.51319251
52Cellulitis (HP:0100658)2.48948147
53Progressive neurologic deterioration (HP:0002344)2.47313818
54Hematochezia (HP:0002573)2.43859307
55Parakeratosis (HP:0001036)2.43639612
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43507357
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.43507357
58Peripheral hypomyelination (HP:0007182)2.42891905
59Personality changes (HP:0000751)2.41039710
60Gastrointestinal stroma tumor (HP:0100723)2.40552167
61Prolonged neonatal jaundice (HP:0006579)2.39625272
62Metaphyseal irregularity (HP:0003025)2.39235272
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.38431244
64Recurrent viral infections (HP:0004429)2.36753546
65Mutism (HP:0002300)2.35385197
66Neuronal loss in central nervous system (HP:0002529)2.35104794
67Chronic otitis media (HP:0000389)2.34858622
68Recurrent pneumonia (HP:0006532)2.33705496
69Supranuclear gaze palsy (HP:0000605)2.32373224
70Thoracic kyphosis (HP:0002942)2.31409534
71Premature skin wrinkling (HP:0100678)2.29904863
72Progressive visual loss (HP:0000529)2.27821793
73Slow saccadic eye movements (HP:0000514)2.26873145
74Increased circulating renin level (HP:0000848)2.24363066
75Retinal atrophy (HP:0001105)2.22514543
76Elevated erythrocyte sedimentation rate (HP:0003565)2.22105766
77Pathologic fracture (HP:0002756)2.21678336
78Vertebral compression fractures (HP:0002953)2.20656524
79Colitis (HP:0002583)2.19619557
80Onion bulb formation (HP:0003383)2.18396753
81Increased IgM level (HP:0003496)2.17904055
82Spondylolisthesis (HP:0003302)2.17132747
83Gingivitis (HP:0000230)2.16920200
84Interstitial pulmonary disease (HP:0006530)2.16538898
85Recurrent cutaneous fungal infections (HP:0011370)2.15188079
86Chronic mucocutaneous candidiasis (HP:0002728)2.15188079
87Nausea (HP:0002018)2.14346260
88Mediastinal lymphadenopathy (HP:0100721)2.14032664
89Inflammation of the large intestine (HP:0002037)2.11744961
90Eosinophilia (HP:0001880)2.09567650
91Prostate neoplasm (HP:0100787)2.08863010
92Cerebral aneurysm (HP:0004944)2.08828692
93Pustule (HP:0200039)2.07989784
94Xanthomatosis (HP:0000991)2.03878118
95Abnormality of iron homeostasis (HP:0011031)2.02899744
96Agnosia (HP:0010524)2.00922644
97* Cardiomegaly (HP:0001640)2.00370903
98Nephritis (HP:0000123)1.99404487
99Vasculitis (HP:0002633)1.99227847
100Hypokalemic alkalosis (HP:0001949)1.98230469
101Aortic aneurysm (HP:0004942)1.96674411
102Dementia (HP:0000726)1.96409642
103Leukocytosis (HP:0001974)1.95484918
104Spontaneous hematomas (HP:0007420)1.94571779
105Inappropriate behavior (HP:0000719)1.94442141
106Myocardial infarction (HP:0001658)1.91576832
107Myositis (HP:0100614)1.91494654
108Osteomyelitis (HP:0002754)1.90971697
109Gingival bleeding (HP:0000225)1.90714879
110Aortic dissection (HP:0002647)1.90652320
111Hypokinesia (HP:0002375)1.89247579
112Gastrointestinal inflammation (HP:0004386)1.86681356
113Hypomagnesemia (HP:0002917)1.86449884
114Bone pain (HP:0002653)1.85144594
115Purpura (HP:0000979)1.85016807
116Thyroiditis (HP:0100646)1.84814199
117Sensory axonal neuropathy (HP:0003390)1.83460983
118Complement deficiency (HP:0004431)1.82797176
119Amyloidosis (HP:0011034)1.81952670
120Persistence of primary teeth (HP:0006335)1.81690799
121Abnormality of eosinophils (HP:0001879)1.81009112
122Polydipsia (HP:0001959)1.80221805
123Abnormal drinking behavior (HP:0030082)1.80221805
124Basal ganglia calcification (HP:0002135)1.79969955
125Generalized aminoaciduria (HP:0002909)1.79799164
126Recurrent lower respiratory tract infections (HP:0002783)1.79194550
127Beaking of vertebral bodies (HP:0004568)1.78738221
128J-shaped sella turcica (HP:0002680)1.78611656
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78266845
130Abnormality of the prostate (HP:0008775)1.77370511
131Abnormality of the periventricular white matter (HP:0002518)1.76814084
132Seborrheic dermatitis (HP:0001051)1.72705376
133Abnormality of the lumbar spine (HP:0100712)1.72591055
134Type I transferrin isoform profile (HP:0003642)1.70929939
135Ragged-red muscle fibers (HP:0003200)1.70266472
136Abnormality of transition element cation homeostasis (HP:0011030)1.69501730
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69033292
138Epistaxis (HP:0000421)1.68774983
139Esophageal neoplasm (HP:0100751)1.67902515
140Neoplasm of head and neck (HP:0012288)1.67902515
141Delusions (HP:0000746)1.67246460
142Amaurosis fugax (HP:0100576)1.65717998
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.64107237
144Urticaria (HP:0001025)1.63237142
145Paralysis (HP:0003470)1.60923245
146Abnormality of pyrimidine metabolism (HP:0004353)1.60008907
147Abnormality of complement system (HP:0005339)1.59647702
148Abnormality of the thoracic spine (HP:0100711)1.59592310
149Aplasia/Hypoplasia of the sacrum (HP:0008517)1.59100014
150Premature loss of primary teeth (HP:0006323)1.58883961
151* Splenomegaly (HP:0001744)1.56968422
152Myoclonus (HP:0001336)1.55614509
153Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.54685319
154Protuberant abdomen (HP:0001538)1.54561040
155Opisthotonus (HP:0002179)1.53672010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.39860214
2TGFBR24.57636678
3STK393.77200872
4EPHB13.76157518
5OXSR13.07596918
6TESK22.87877402
7PDK22.57386396
8CSF1R2.49268740
9VRK22.44648624
10GRK72.25127066
11TRIM282.22186140
12TESK12.20222747
13BLK2.19994678
14MAPK152.18465934
15MAP4K12.16638935
16IRAK42.11732313
17MAP3K142.09569459
18ABL22.05773586
19CLK12.03553405
20TYK22.01372132
21MAP3K111.96135128
22TAOK21.94304228
23KIT1.92343234
24ITK1.88921025
25IRAK31.82908865
26BCKDK1.77791252
27CAMK1D1.73809534
28STK101.71904555
29RIPK41.69766533
30CAMK1G1.68773814
31PBK1.68529659
32PIM21.67927533
33TBK11.67631751
34IKBKB1.64016236
35PKN11.60507697
36MAP3K31.54579411
37MST41.53813306
38WNK11.52676596
39WNK41.47677600
40FGR1.47497176
41BUB11.47141265
42JAK11.43110978
43EIF2AK11.41538519
44CSK1.38329600
45MUSK1.33959002
46HCK1.30240708
47TEC1.25837914
48STK161.25006584
49TAOK11.23714386
50LIMK11.23541441
51MAP2K31.22987044
52SMG11.22805139
53MAP3K131.19942087
54LCK1.18278096
55TXK1.18021750
56TRPM71.16983019
57ZAP701.15593551
58IKBKE1.14583751
59MAPKAPK51.12161497
60GRK61.09006830
61LYN1.08317239
62BTK1.08082911
63JAK31.07159369
64DAPK11.06914474
65ICK1.06896928
66MAP3K11.06813169
67CDK121.04293980
68KDR1.02719601
69MET1.02011141
70SIK31.00639906
71CSNK1A1L0.94184093
72ADRBK20.92741129
73EPHA20.91946825
74ARAF0.91293331
75FGFR20.86901181
76SYK0.82349176
77ERN10.82183816
78MATK0.79096605
79PRKCQ0.78396729
80MAP3K80.76649154
81FES0.75118416
82CAMKK20.72308215
83IRAK20.71329840
84IRAK10.71111152
85MARK30.70453437
86DDR20.70107940
87CHUK0.67712777
88NEK60.66869830
89CSNK1G30.66515576
90ROCK20.64094151
91PDPK10.63485193
92CDC42BPA0.63239951
93PDGFRB0.62937319
94CSNK1G10.61206033
95EGFR0.60932957
96BMX0.60663423
97MAP3K50.59904963
98ACVR1B0.59300734
99MAPKAPK20.59281122
100PRPF4B0.59126020
101MAPK70.58746020
102ABL10.57943481
103TNIK0.57448619
104PRKD10.56463625
105BMPR1B0.55789392
106CDK190.55645437
107MAP3K120.55027962
108JAK20.54878147
109EPHA30.53621316
110MAPK120.53250511
111TAOK30.53155847
112STK40.53010722
113PDK10.52763392
114TNK20.52652812
115FYN0.52585015
116BRD40.52312713
117GSK3A0.50900775
118PAK20.50626284
119NME10.49911350
120INSR0.49693352
121SIK10.49574899
122RPS6KA50.49385310
123DAPK30.49287694
124NEK90.49145216
125CDK90.45142587
126NUAK10.44947595
127VRK10.42801045
128PAK10.42592866
129IGF1R0.42351028
130YES10.42330571
131LRRK20.41658823
132MOS0.41360870
133DMPK0.40135531
134PAK40.39700333
135PRKCD0.39014824
136CDK60.38233409
137BMPR20.36486751
138CDK70.36467314
139PRKAA20.35155622
140MELK0.34380520
141CSNK2A10.34364288
142CAMK2G0.34304422
143STK30.34020317
144CDK30.33853038
145FGFR40.33768129
146PIM10.33708036
147CSNK1G20.33364087
148ILK0.32108442
149RPS6KC10.26690824
150RPS6KL10.26690824
151FLT30.24063718
152SCYL20.23497891

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041423.13012159
2Staphylococcus aureus infection_Homo sapiens_hsa051502.95566363
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.86682035
4Other glycan degradation_Homo sapiens_hsa005112.74051625
5Osteoclast differentiation_Homo sapiens_hsa043802.39139184
6Proteasome_Homo sapiens_hsa030502.35533010
7Leishmaniasis_Homo sapiens_hsa051402.34315766
8Steroid biosynthesis_Homo sapiens_hsa001002.22468306
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22002287
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15065819
11B cell receptor signaling pathway_Homo sapiens_hsa046622.12451055
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.12360417
13Malaria_Homo sapiens_hsa051441.90407192
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.87757625
15Rheumatoid arthritis_Homo sapiens_hsa053231.86696116
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85005329
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84744478
18Ether lipid metabolism_Homo sapiens_hsa005651.81682669
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.80098922
20Galactose metabolism_Homo sapiens_hsa000521.76280477
21Pertussis_Homo sapiens_hsa051331.74953491
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69728855
23Sphingolipid metabolism_Homo sapiens_hsa006001.69105265
24Tuberculosis_Homo sapiens_hsa051521.67881850
25Hematopoietic cell lineage_Homo sapiens_hsa046401.57083376
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.52843415
27Phagosome_Homo sapiens_hsa041451.46161777
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.42653233
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40435708
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39173092
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39083841
32Antigen processing and presentation_Homo sapiens_hsa046121.37146695
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36904340
34Vibrio cholerae infection_Homo sapiens_hsa051101.34490637
35Glutathione metabolism_Homo sapiens_hsa004801.34036041
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33936812
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33298687
38Primary immunodeficiency_Homo sapiens_hsa053401.32981103
39Measles_Homo sapiens_hsa051621.32857043
40Sulfur metabolism_Homo sapiens_hsa009201.30647515
41Chemokine signaling pathway_Homo sapiens_hsa040621.29889861
42Fatty acid elongation_Homo sapiens_hsa000621.29160255
43Toxoplasmosis_Homo sapiens_hsa051451.26189851
44Salmonella infection_Homo sapiens_hsa051321.24464205
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.24242336
46Base excision repair_Homo sapiens_hsa034101.23742560
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22822273
48DNA replication_Homo sapiens_hsa030301.22376392
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20623368
50Graft-versus-host disease_Homo sapiens_hsa053321.19078144
51Allograft rejection_Homo sapiens_hsa053301.17444090
52Pentose phosphate pathway_Homo sapiens_hsa000301.14291926
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13614206
54Legionellosis_Homo sapiens_hsa051341.12231857
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11793805
56Fructose and mannose metabolism_Homo sapiens_hsa000511.11358853
57T cell receptor signaling pathway_Homo sapiens_hsa046601.09356068
58Type I diabetes mellitus_Homo sapiens_hsa049401.08629968
59Mismatch repair_Homo sapiens_hsa034301.07913654
60Shigellosis_Homo sapiens_hsa051311.07408002
61Oxidative phosphorylation_Homo sapiens_hsa001901.06800031
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04284893
63Asthma_Homo sapiens_hsa053101.04000969
64Renal cell carcinoma_Homo sapiens_hsa052111.02001520
65Autoimmune thyroid disease_Homo sapiens_hsa053201.00685596
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.00340438
67Nitrogen metabolism_Homo sapiens_hsa009101.00290216
68Pancreatic cancer_Homo sapiens_hsa052120.99110378
69Endocytosis_Homo sapiens_hsa041440.98380060
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.95531758
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94259423
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91545466
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.88055094
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.87643466
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84696849
76Carbon metabolism_Homo sapiens_hsa012000.84494415
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84469507
78Influenza A_Homo sapiens_hsa051640.84243059
79Chronic myeloid leukemia_Homo sapiens_hsa052200.84072098
80N-Glycan biosynthesis_Homo sapiens_hsa005100.83506939
81TNF signaling pathway_Homo sapiens_hsa046680.82178443
82Apoptosis_Homo sapiens_hsa042100.80194072
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78965586
84Mineral absorption_Homo sapiens_hsa049780.78826705
85Pyrimidine metabolism_Homo sapiens_hsa002400.78566359
86Hepatitis C_Homo sapiens_hsa051600.78534332
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78181418
88PPAR signaling pathway_Homo sapiens_hsa033200.75565334
89Hepatitis B_Homo sapiens_hsa051610.74127145
90Sulfur relay system_Homo sapiens_hsa041220.73639985
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73475519
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72739241
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71736958
94Notch signaling pathway_Homo sapiens_hsa043300.70784677
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68924052
96Epstein-Barr virus infection_Homo sapiens_hsa051690.68918402
97Herpes simplex infection_Homo sapiens_hsa051680.68696573
98Platelet activation_Homo sapiens_hsa046110.68140218
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66986760
100Collecting duct acid secretion_Homo sapiens_hsa049660.64201611
101Viral myocarditis_Homo sapiens_hsa054160.63291086
102Acute myeloid leukemia_Homo sapiens_hsa052210.62230762
103Dorso-ventral axis formation_Homo sapiens_hsa043200.60103521
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59985496
105RNA polymerase_Homo sapiens_hsa030200.59277056
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59252385
107Prion diseases_Homo sapiens_hsa050200.58249797
108Amoebiasis_Homo sapiens_hsa051460.56602015
109Arachidonic acid metabolism_Homo sapiens_hsa005900.56442578
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55686492
111Biosynthesis of amino acids_Homo sapiens_hsa012300.55210074
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53062229
113African trypanosomiasis_Homo sapiens_hsa051430.53047000
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52361280
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.52189918
116Vitamin digestion and absorption_Homo sapiens_hsa049770.51993579
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51372080
118Renin-angiotensin system_Homo sapiens_hsa046140.48310510
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46551109
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46066791
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44491890
122Histidine metabolism_Homo sapiens_hsa003400.43813345
123Prostate cancer_Homo sapiens_hsa052150.42656917
124Ribosome_Homo sapiens_hsa030100.42190616
125Axon guidance_Homo sapiens_hsa043600.41581961
126Ras signaling pathway_Homo sapiens_hsa040140.41152964
127Choline metabolism in cancer_Homo sapiens_hsa052310.40873142
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.40606987
129Folate biosynthesis_Homo sapiens_hsa007900.38833654
130Parkinsons disease_Homo sapiens_hsa050120.38619498
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37327600
132ECM-receptor interaction_Homo sapiens_hsa045120.36574804
133Homologous recombination_Homo sapiens_hsa034400.36201455
134Complement and coagulation cascades_Homo sapiens_hsa046100.36135013
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35193153
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34934721
137ABC transporters_Homo sapiens_hsa020100.34928258
138MAPK signaling pathway_Homo sapiens_hsa040100.34779954
139Metabolic pathways_Homo sapiens_hsa011000.34482161
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33889636
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33515279
142Proteoglycans in cancer_Homo sapiens_hsa052050.32523406
143Vitamin B6 metabolism_Homo sapiens_hsa007500.32445321
144Bladder cancer_Homo sapiens_hsa052190.31646690
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28959069

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