SLC26A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid gland development (GO:0030878)8.65712845
2surfactant homeostasis (GO:0043129)6.18576178
3drug transmembrane transport (GO:0006855)5.57903615
4urate metabolic process (GO:0046415)5.57080351
5phosphate ion transport (GO:0006817)5.55975867
6regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.55857445
7chemical homeostasis within a tissue (GO:0048875)5.54541887
8cellular response to gonadotropin stimulus (GO:0071371)5.01768194
9phosphate ion transmembrane transport (GO:0035435)4.96540914
10aminoglycoside antibiotic metabolic process (GO:0030647)4.95839819
11nephron tubule formation (GO:0072079)4.78741926
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.77929615
13behavioral response to nicotine (GO:0035095)4.73871357
14exogenous drug catabolic process (GO:0042738)4.62041683
15drug transport (GO:0015893)4.57413328
16phenol-containing compound metabolic process (GO:0018958)4.57158769
17drug catabolic process (GO:0042737)4.53110176
18negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.44003701
19hydrogen peroxide catabolic process (GO:0042744)4.28769822
20hormone biosynthetic process (GO:0042446)4.22349783
21organic cation transport (GO:0015695)4.16044543
22excretion (GO:0007588)4.04564033
23negative regulation of metanephros development (GO:0072217)4.03005834
24lysine catabolic process (GO:0006554)4.02059303
25lysine metabolic process (GO:0006553)4.02059303
26female gonad development (GO:0008585)3.84890186
27* sulfate transmembrane transport (GO:1902358)3.84566277
28pattern specification involved in kidney development (GO:0061004)3.80748983
29metanephric tubule development (GO:0072170)3.78870671
30metanephric nephron tubule development (GO:0072234)3.78870671
31quaternary ammonium group transport (GO:0015697)3.76456450
32regulation of mesenchymal cell apoptotic process (GO:2001053)3.75682262
33mesonephros development (GO:0001823)3.75444173
34regulation of apoptotic process involved in morphogenesis (GO:1902337)3.70937692
35response to mercury ion (GO:0046689)3.68838901
36urogenital system development (GO:0001655)3.68237889
37cysteine metabolic process (GO:0006534)3.64827008
38metanephric nephron epithelium development (GO:0072243)3.64007834
39sulfation (GO:0051923)3.57195054
40regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.53347587
41positive regulation of metanephros development (GO:0072216)3.51107873
42beta-amyloid metabolic process (GO:0050435)3.51075307
43cellular potassium ion homeostasis (GO:0030007)3.49576128
44negative regulation of hormone biosynthetic process (GO:0032353)3.48920279
45short-chain fatty acid metabolic process (GO:0046459)3.42080713
46cellular response to ATP (GO:0071318)3.40860771
47phosphate ion homeostasis (GO:0055062)3.36113685
48trivalent inorganic anion homeostasis (GO:0072506)3.36113685
49peptide catabolic process (GO:0043171)3.35939632
50* sulfate transport (GO:0008272)3.34741643
51gonadal mesoderm development (GO:0007506)3.29815166
52water-soluble vitamin biosynthetic process (GO:0042364)3.29780587
53nonribosomal peptide biosynthetic process (GO:0019184)3.29664310
54sodium-independent organic anion transport (GO:0043252)3.27454734
55positive regulation of hormone metabolic process (GO:0032352)3.25843625
56metanephric epithelium development (GO:0072207)3.25303315
57response to gonadotropin (GO:0034698)3.25128721
58lung lobe morphogenesis (GO:0060463)3.23148318
59response to xenobiotic stimulus (GO:0009410)3.15502925
60regulation of inositol phosphate biosynthetic process (GO:0010919)3.11125653
61positive regulation of digestive system process (GO:0060456)3.10749850
62positive regulation of fatty acid oxidation (GO:0046321)3.09450488
63positive regulation of fatty acid beta-oxidation (GO:0032000)3.08622494
64glutathione biosynthetic process (GO:0006750)3.05846886
65membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.03374475
66homocysteine metabolic process (GO:0050667)3.00373955
67thyroid hormone generation (GO:0006590)23.0553732
68negative regulation of kidney development (GO:0090185)2.99954976
69specification of organ identity (GO:0010092)2.97860721
70calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.96574622
71negative regulation of response to food (GO:0032096)2.95998348
72negative regulation of appetite (GO:0032099)2.95998348
73vitamin D metabolic process (GO:0042359)2.95673872
74glyoxylate metabolic process (GO:0046487)2.95568902
75embryonic epithelial tube formation (GO:0001838)2.95389815
76membrane repolarization during action potential (GO:0086011)2.93949880
77negative regulation of microtubule polymerization (GO:0031115)2.93052052
78sodium ion export (GO:0071436)2.92906528
79renal absorption (GO:0070293)2.91639280
80angiotensin maturation (GO:0002003)2.91383573
81atrial cardiac muscle cell action potential (GO:0086014)2.89426042
82negative regulation of hormone metabolic process (GO:0032351)2.87968759
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87753248
84embryonic hemopoiesis (GO:0035162)2.86288357
85mesenchymal to epithelial transition (GO:0060231)2.86282239
86glycoside metabolic process (GO:0016137)2.85710609
87regulation of clathrin-mediated endocytosis (GO:2000369)2.85479954
88cellular ketone body metabolic process (GO:0046950)2.82948368
89positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.81941767
90positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.80011899
91hydrogen peroxide metabolic process (GO:0042743)2.79599354
92kidney morphogenesis (GO:0060993)2.79494498
93aspartate family amino acid catabolic process (GO:0009068)2.79030527
94carnitine transport (GO:0015879)2.75804168
95amino-acid betaine transport (GO:0015838)2.75804168
96epithelial tube formation (GO:0072175)2.74105436
97response to parathyroid hormone (GO:0071107)2.73852123
98kynurenine metabolic process (GO:0070189)2.73791394
99cellular sodium ion homeostasis (GO:0006883)2.73022329
100nephron tubule development (GO:0072080)2.71281787
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70846378
102regulation of stem cell maintenance (GO:2000036)2.70683193
103cellular modified amino acid catabolic process (GO:0042219)2.70380407
104transepithelial transport (GO:0070633)2.70098017
105locomotory exploration behavior (GO:0035641)2.69717527
106sodium ion homeostasis (GO:0055078)2.65706204
107ionotropic glutamate receptor signaling pathway (GO:0035235)2.64806919
108hormone metabolic process (GO:0042445)2.63600312
109L-fucose catabolic process (GO:0042355)2.62978348
110fucose catabolic process (GO:0019317)2.62978348
111L-fucose metabolic process (GO:0042354)2.62978348
112sodium ion transport (GO:0006814)2.62833543
113lung vasculature development (GO:0060426)2.61664350
114flavonoid metabolic process (GO:0009812)2.61634726
115toxin transport (GO:1901998)2.60214819
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.60165880
117positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.59772351
118tricarboxylic acid metabolic process (GO:0072350)2.59771897
119citrulline biosynthetic process (GO:0019240)2.59474219
120ketone body metabolic process (GO:1902224)2.58662974
121valine metabolic process (GO:0006573)2.57875173
122axoneme assembly (GO:0035082)2.57510909
123serotonin metabolic process (GO:0042428)2.57067352
124membrane repolarization (GO:0086009)2.56570143
125modified amino acid transport (GO:0072337)2.55812990
126cAMP catabolic process (GO:0006198)2.54283621
127primary amino compound metabolic process (GO:1901160)2.53756388
128cell communication by electrical coupling (GO:0010644)2.53094054
1294-hydroxyproline metabolic process (GO:0019471)2.52029500
130vocalization behavior (GO:0071625)2.51592305
131positive regulation of respiratory burst (GO:0060267)2.51098345
132indole-containing compound metabolic process (GO:0042430)2.50898280
133indole-containing compound catabolic process (GO:0042436)2.50780765
134indolalkylamine catabolic process (GO:0046218)2.50780765
135tryptophan catabolic process (GO:0006569)2.50780765
136keratinization (GO:0031424)2.50500601
137reflex (GO:0060004)2.49963616
138vitamin transmembrane transport (GO:0035461)2.49104095
139positive regulation of mesonephros development (GO:0061213)2.49000067
140indolalkylamine metabolic process (GO:0006586)2.47024018
141positive regulation of potassium ion transmembrane transport (GO:1901381)2.46776325
142adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.46554261
143regulation of cilium movement (GO:0003352)2.45429708
144regulation of energy homeostasis (GO:2000505)2.45276022
145protein polyglutamylation (GO:0018095)2.44670767
146cochlea development (GO:0090102)2.43703029
147synapse assembly (GO:0007416)2.43568395
148regulation of metanephros development (GO:0072215)2.43557009
149regulation of hippo signaling (GO:0035330)2.42899450
150endothelial cell chemotaxis (GO:0035767)2.42196182
151neuronal action potential (GO:0019228)2.42039107
152cellular response to ammonium ion (GO:0071242)2.41639618
153epithelial cilium movement (GO:0003351)2.40401788
154negative regulation of blood pressure (GO:0045776)2.40148198
155regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.39297983
156regulation of myelination (GO:0031641)2.37956169
157gamma-aminobutyric acid transport (GO:0015812)2.37635890
158cardiovascular system development (GO:0072358)2.37514115
159glutamate receptor signaling pathway (GO:0007215)2.37295978
160L-phenylalanine metabolic process (GO:0006558)2.36870522
161erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36870522
162renal tubule development (GO:0061326)2.35938027
163membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35627696
164nonmotile primary cilium assembly (GO:0035058)2.34518062
165regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.34438717
166hypotonic response (GO:0006971)2.34013119
167fructose metabolic process (GO:0006000)2.31958524
168sodium ion transmembrane transport (GO:0035725)2.31816909
169branched-chain amino acid metabolic process (GO:0009081)2.31807563
170fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.31521883
171regulation of action potential (GO:0098900)2.31293690
172cell volume homeostasis (GO:0006884)2.31200026
173complement activation, alternative pathway (GO:0006957)2.31129842
174transmission of nerve impulse (GO:0019226)2.30975787
175bicarbonate transport (GO:0015701)2.30875955
176response to magnesium ion (GO:0032026)2.30579923
177erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.29511535
178L-phenylalanine catabolic process (GO:0006559)2.29511535
179nephron epithelium development (GO:0072009)2.29400404
180peptide biosynthetic process (GO:0043043)2.28724979
181serine family amino acid catabolic process (GO:0009071)2.28627517
182cyclic nucleotide catabolic process (GO:0009214)2.28619411
183negative regulation of telomere maintenance (GO:0032205)2.28313095
184negative regulation of systemic arterial blood pressure (GO:0003085)2.28239581
185nephron epithelium morphogenesis (GO:0072088)2.26847813
186nephron tubule morphogenesis (GO:0072078)2.26847813
187exploration behavior (GO:0035640)2.26682322
188regulation of acrosome reaction (GO:0060046)2.26462577
189negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.25526383
190regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.20972922
191response to pheromone (GO:0019236)2.20851889
192thyroid hormone metabolic process (GO:0042403)19.3306758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human2.55315984
2ESR2_21235772_ChIP-Seq_MCF-7_Human2.54207724
3EZH2_22144423_ChIP-Seq_EOC_Human2.51135238
4VDR_22108803_ChIP-Seq_LS180_Human2.47487830
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35660946
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19591142
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15938808
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14894348
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13943202
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02994946
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02867448
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01390612
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01390612
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98681227
15* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95625398
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94625086
17FUS_26573619_Chip-Seq_HEK293_Human1.93456524
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90887320
19TAF15_26573619_Chip-Seq_HEK293_Human1.87167410
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86790549
21AHR_22903824_ChIP-Seq_MCF-7_Human1.86585475
22IGF1R_20145208_ChIP-Seq_DFB_Human1.86509643
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85776720
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85422156
25* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85101243
26GBX2_23144817_ChIP-Seq_PC3_Human1.81521001
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78913450
28P300_19829295_ChIP-Seq_ESCs_Human1.78639422
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75506614
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75430680
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.74933245
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.68889567
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.68773485
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66980161
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.66699470
36DROSHA_22980978_ChIP-Seq_HELA_Human1.63317695
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62424328
38AR_21572438_ChIP-Seq_LNCaP_Human1.61902560
39EWS_26573619_Chip-Seq_HEK293_Human1.61783826
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59864368
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59404061
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58193385
43REST_21632747_ChIP-Seq_MESCs_Mouse1.56304369
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55822318
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52127741
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.51905804
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51829410
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.51506288
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50847262
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.49172604
51STAT3_23295773_ChIP-Seq_U87_Human1.48685397
52* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48624004
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.46965446
54* ER_23166858_ChIP-Seq_MCF-7_Human1.46019304
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.45841786
56SOX2_20726797_ChIP-Seq_SW620_Human1.45793548
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.45568802
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45451455
59CLOCK_20551151_ChIP-Seq_293T_Human1.44626412
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.43793932
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43418906
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.42614229
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41849312
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41560443
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.40666980
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39672709
67CBP_20019798_ChIP-Seq_JUKART_Human1.39672709
68IRF1_19129219_ChIP-ChIP_H3396_Human1.39324432
69* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38040864
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37369751
71ZNF274_21170338_ChIP-Seq_K562_Hela1.35149772
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.34119472
73TCF4_23295773_ChIP-Seq_U87_Human1.33553265
74* RNF2_27304074_Chip-Seq_NSC_Mouse1.33000804
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32595382
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31867894
77TP53_22573176_ChIP-Seq_HFKS_Human1.31548370
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30740335
79* RNF2_27304074_Chip-Seq_ESCs_Mouse1.30669320
80RUNX2_22187159_ChIP-Seq_PCA_Human1.30668964
81* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30653198
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.30589832
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.29135595
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27874427
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27750045
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27501503
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.27420236
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.26611530
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25831354
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25747163
91TCF4_22108803_ChIP-Seq_LS180_Human1.25084198
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23504697
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.22905373
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22895002
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22895002
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20781383
97TP53_18474530_ChIP-ChIP_U2OS_Human1.20002697
98ZNF263_19887448_ChIP-Seq_K562_Human1.18053523
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17853871
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17797196
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17363085
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16713520
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16090164
104RXR_22108803_ChIP-Seq_LS180_Human1.15582267
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15175973
106* SMAD4_21799915_ChIP-Seq_A2780_Human1.13467967
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.13277874
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13205890
109NANOG_19829295_ChIP-Seq_ESCs_Human1.13141920
110SOX2_19829295_ChIP-Seq_ESCs_Human1.13141920
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11887236
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11773670
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11744882
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11559040
115AR_25329375_ChIP-Seq_VCAP_Human1.11169980
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10567609
117RUNX1_27514584_Chip-Seq_MCF-7_Human1.10471402
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10420670
119PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10009410
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09280040
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09014001
122* REST_18959480_ChIP-ChIP_MESCs_Mouse1.07680251
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07582269
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05753437
125NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05753437
126* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05148545
127FOXA2_19822575_ChIP-Seq_HepG2_Human1.03476342
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01342962
129GATA3_21878914_ChIP-Seq_MCF-7_Human1.01319856
130FLI1_27457419_Chip-Seq_LIVER_Mouse1.00491629
131KDM2B_26808549_Chip-Seq_K562_Human1.00329245
132SMAD4_21741376_ChIP-Seq_HESCs_Human1.00036722
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00000946
134TP53_16413492_ChIP-PET_HCT116_Human0.99956013
135GATA4_25053715_ChIP-Seq_YYC3_Human0.99666404
136FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99453092
137FOXA1_25329375_ChIP-Seq_VCAP_Human0.99453092
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99144985
139BCAT_22108803_ChIP-Seq_LS180_Human0.98136786
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97199582
141* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97197527
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.96632374
143NCOR_22424771_ChIP-Seq_293T_Human0.96504603
144* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96072294
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95844362
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95510229
147RACK7_27058665_Chip-Seq_MCF-7_Human0.95086418
148LXR_22292898_ChIP-Seq_THP-1_Human0.94981722
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94659274
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93889007
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93714191
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91766466
153SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90929852
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90534130
155* RING1B_27294783_Chip-Seq_NPCs_Mouse0.90188457
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.87912858
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86745289
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86226379
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.85459664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.98494024
2MP0004043_abnormal_pH_regulation4.11426022
3MP0000383_abnormal_hair_follicle4.07030485
4MP0005360_urolithiasis3.76932512
5* MP0001765_abnormal_ion_homeostasis3.74117739
6MP0004019_abnormal_vitamin_homeostasis3.44304948
7MP0001958_emphysema3.34692602
8MP0002138_abnormal_hepatobiliary_system3.05073425
9MP0004859_abnormal_synaptic_plasticity3.03603339
10MP0005332_abnormal_amino_acid2.78060955
11MP0002139_abnormal_hepatobiliary_system2.68166399
12MP0005636_abnormal_mineral_homeostasis2.60957244
13* MP0009643_abnormal_urine_homeostasis2.50680224
14MP0004782_abnormal_surfactant_physiolog2.47210885
15MP0003880_abnormal_central_pattern2.46985842
16MP0001756_abnormal_urination2.39130919
17MP0010386_abnormal_urinary_bladder2.29995250
18MP0008875_abnormal_xenobiotic_pharmacok2.22545970
19MP0009780_abnormal_chondrocyte_physiolo2.13273872
20MP0002136_abnormal_kidney_physiology2.03055860
21MP0003646_muscle_fatigue1.87853626
22MP0000631_abnormal_neuroendocrine_gland1.76920855
23* MP0001485_abnormal_pinna_reflex1.75118229
24MP0004858_abnormal_nervous_system1.71284211
25MP0003329_amyloid_beta_deposits1.70699645
26MP0005310_abnormal_salivary_gland1.68500505
27MP0003635_abnormal_synaptic_transmissio1.64853779
28MP0001440_abnormal_grooming_behavior1.63836338
29MP0002272_abnormal_nervous_system1.63620928
30MP0005646_abnormal_pituitary_gland1.59033765
31MP0005167_abnormal_blood-brain_barrier1.58603911
32MP0000538_abnormal_urinary_bladder1.58109397
33MP0005058_abnormal_lysosome_morphology1.58082515
34MP0002796_impaired_skin_barrier1.56523430
35MP0000604_amyloidosis1.55433688
36MP0002909_abnormal_adrenal_gland1.55047874
37MP0000537_abnormal_urethra_morphology1.54280099
38MP0000372_irregular_coat_pigmentation1.52597991
39MP0005551_abnormal_eye_electrophysiolog1.52374085
40MP0004133_heterotaxia1.51347466
41MP0003938_abnormal_ear_development1.46675723
42MP0005085_abnormal_gallbladder_physiolo1.45729744
43MP0008872_abnormal_physiological_respon1.45229691
44MP0003195_calcinosis1.45203290
45MP0001664_abnormal_digestion1.41509471
46MP0010678_abnormal_skin_adnexa1.39650192
47MP0002653_abnormal_ependyma_morphology1.38212229
48MP0008569_lethality_at_weaning1.38190210
49MP0003075_altered_response_to1.37439523
50MP0002837_dystrophic_cardiac_calcinosis1.37400380
51MP0002938_white_spotting1.37241266
52* MP0000026_abnormal_inner_ear1.35885212
53MP0001666_abnormal_nutrient_absorption1.35519921
54MP0004264_abnormal_extraembryonic_tissu1.34922723
55* MP0001963_abnormal_hearing_physiology1.32328242
56MP0003890_abnormal_embryonic-extraembry1.32183166
57MP0002295_abnormal_pulmonary_circulatio1.31694764
58MP0003011_delayed_dark_adaptation1.31103892
59MP0002063_abnormal_learning/memory/cond1.30980186
60MP0008961_abnormal_basal_metabolism1.29883830
61MP0003252_abnormal_bile_duct1.29775010
62MP0001177_atelectasis1.29701722
63MP0005377_hearing/vestibular/ear_phenot1.28176470
64MP0003878_abnormal_ear_physiology1.28176470
65MP0004270_analgesia1.27330537
66MP0000049_abnormal_middle_ear1.26967274
67MP0002735_abnormal_chemical_nociception1.25613074
68MP0002234_abnormal_pharynx_morphology1.25040775
69MP0009745_abnormal_behavioral_response1.24694225
70MP0008877_abnormal_DNA_methylation1.24259989
71MP0002638_abnormal_pupillary_reflex1.24226546
72MP0000230_abnormal_systemic_arterial1.23618860
73MP0005166_decreased_susceptibility_to1.22189490
74MP0003879_abnormal_hair_cell1.21473357
75* MP0004885_abnormal_endolymph1.21375216
76MP0000569_abnormal_digit_pigmentation1.18553551
77MP0004484_altered_response_of1.17248946
78MP0005083_abnormal_biliary_tract1.17082002
79MP0009046_muscle_twitch1.16661407
80MP0001501_abnormal_sleep_pattern1.11655075
81MP0002102_abnormal_ear_morphology1.09955250
82MP0008004_abnormal_stomach_pH1.09286744
83MP0001984_abnormal_olfaction1.08871422
84MP0004134_abnormal_chest_morphology1.07246377
85MP0005365_abnormal_bile_salt1.06711709
86MP0008995_early_reproductive_senescence1.06343230
87MP0002064_seizures1.06199348
88MP0002876_abnormal_thyroid_physiology1.02219223
89MP0003045_fibrosis1.02000488
90MP0001486_abnormal_startle_reflex1.01182818
91MP0003191_abnormal_cellular_cholesterol1.01002017
92MP0005253_abnormal_eye_physiology1.00913611
93MP0004147_increased_porphyrin_level1.00373051
94MP0006072_abnormal_retinal_apoptosis0.99802377
95MP0005319_abnormal_enzyme/_coenzyme0.99111839
96MP0002736_abnormal_nociception_after0.98825957
97MP0004272_abnormal_basement_membrane0.98184123
98MP0003953_abnormal_hormone_level0.97816557
99MP0000566_synostosis0.97244763
100MP0006292_abnormal_olfactory_placode0.97018661
101MP0001970_abnormal_pain_threshold0.93555289
102MP0009250_abnormal_appendicular_skeleto0.90617273
103MP0005645_abnormal_hypothalamus_physiol0.90122311
104MP0010368_abnormal_lymphatic_system0.89812694
105MP0002160_abnormal_reproductive_system0.89603760
106MP0003638_abnormal_response/metabolism_0.88813318
107MP0002133_abnormal_respiratory_system0.88685603
108MP0005388_respiratory_system_phenotype0.88685603
109MP0005165_increased_susceptibility_to0.87743090
110MP0001968_abnormal_touch/_nociception0.87725841
111MP0005389_reproductive_system_phenotype0.87188848
112MP0003136_yellow_coat_color0.87028466
113MP0002168_other_aberrant_phenotype0.86892907
114MP0005174_abnormal_tail_pigmentation0.86583337
115MP0005595_abnormal_vascular_smooth0.85980839
116MP0002734_abnormal_mechanical_nocicepti0.83513871
117MP0003937_abnormal_limbs/digits/tail_de0.83512130
118MP0004130_abnormal_muscle_cell0.82957728
119MP0002254_reproductive_system_inflammat0.82730741
120MP0000534_abnormal_ureter_morphology0.82367211
121MP0005584_abnormal_enzyme/coenzyme_acti0.82331415
122MP0002572_abnormal_emotion/affect_behav0.81816450
123MP0004145_abnormal_muscle_electrophysio0.81421729
124MP0000427_abnormal_hair_cycle0.80895299
125MP0002067_abnormal_sensory_capabilities0.80487933
126MP0001986_abnormal_taste_sensitivity0.80301616
127MP0003283_abnormal_digestive_organ0.79151968
128MP0003137_abnormal_impulse_conducting0.78475729
129MP0006276_abnormal_autonomic_nervous0.78284496
130MP0002135_abnormal_kidney_morphology0.78088770
131* MP0004742_abnormal_vestibular_system0.76759404
132MP0000678_abnormal_parathyroid_gland0.76456794
133MP0000681_abnormal_thyroid_gland0.74428995
134MP0000778_abnormal_nervous_system0.73715748
135MP0002184_abnormal_innervation0.73422934
136MP0005171_absent_coat_pigmentation0.72156933
137MP0001905_abnormal_dopamine_level0.71666098
138MP0002118_abnormal_lipid_homeostasis0.71637587
139* MP0002752_abnormal_somatic_nervous0.70330737
140MP0005535_abnormal_body_temperature0.69892077
141MP0004142_abnormal_muscle_tone0.68704685
142MP0003868_abnormal_feces_composition0.68279090
143MP0003787_abnormal_imprinting0.67909020
144MP0005386_behavior/neurological_phenoty0.67861371
145MP0004924_abnormal_behavior0.67861371
146* MP0002229_neurodegeneration0.67654996
147MP0001919_abnormal_reproductive_system0.66605902
148MP0005647_abnormal_sex_gland0.65658156
149MP0005075_abnormal_melanosome_morpholog0.64752601
150MP0000747_muscle_weakness0.62082848
151MP0002733_abnormal_thermal_nociception0.61807420
152MP0006138_congestive_heart_failure0.60801484
153MP0005084_abnormal_gallbladder_morpholo0.59664924
154MP0002557_abnormal_social/conspecific_i0.59415349
155MP0005501_abnormal_skin_physiology0.58353086
156MP0005187_abnormal_penis_morphology0.58331959
157MP0002928_abnormal_bile_duct0.57137472
158MP0002896_abnormal_bone_mineralization0.56362787
159MP0003115_abnormal_respiratory_system0.55779478
160MP0005275_abnormal_skin_tensile0.55629435
161MP0001502_abnormal_circadian_rhythm0.54890720
162MP0009764_decreased_sensitivity_to0.54772803
163MP0005381_digestive/alimentary_phenotyp0.53297037
164MP0001663_abnormal_digestive_system0.52983454

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.61459209
2Gout (HP:0001997)7.17583652
3Increased circulating renin level (HP:0000848)6.56471173
4Small epiphyses (HP:0010585)6.16794041
5* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)6.15453903
6Hypokalemic alkalosis (HP:0001949)6.10193791
7Abnormality of chloride homeostasis (HP:0011422)5.92041195
8Pili torti (HP:0003777)5.91886959
9Hypomagnesemia (HP:0002917)5.73719151
10Metabolic alkalosis (HP:0200114)5.70875081
11Hypothermia (HP:0002045)5.52107518
12Hyperthyroidism (HP:0000836)5.42461246
13Renal salt wasting (HP:0000127)5.10970602
14Abnormality of renal excretion (HP:0011036)5.07974940
15Abnormality of renin-angiotensin system (HP:0000847)4.90619671
16Abnormality of magnesium homeostasis (HP:0004921)4.82576921
17Abnormal urine output (HP:0012590)4.78946541
18Polyuria (HP:0000103)4.78823307
19Hyperaldosteronism (HP:0000859)4.62890806
20Hyperuricemia (HP:0002149)4.50735931
21Increased purine levels (HP:0004368)4.50735931
22Tetany (HP:0001281)4.14762799
23Irregular epiphyses (HP:0010582)4.14310233
24Delayed epiphyseal ossification (HP:0002663)4.11904801
25Abnormal drinking behavior (HP:0030082)3.98563047
26Polydipsia (HP:0001959)3.98563047
27Alkalosis (HP:0001948)3.92893653
28Abnormal hair laboratory examination (HP:0003328)3.77082957
29Abnormality of purine metabolism (HP:0004352)3.73637760
30Pancreatic cysts (HP:0001737)3.64607835
31Interstitial pulmonary disease (HP:0006530)3.54697658
32Pancreatic fibrosis (HP:0100732)3.47862305
33True hermaphroditism (HP:0010459)3.36332033
34Hyperglycinuria (HP:0003108)3.27371518
35Mild short stature (HP:0003502)3.25859580
36* Hypothyroidism (HP:0000821)3.24041843
37Tubulointerstitial fibrosis (HP:0005576)3.23882124
38Proximal tubulopathy (HP:0000114)3.22850861
39Epiphyseal dysplasia (HP:0002656)3.17059953
40Abnormality of glutamine family amino acid metabolism (HP:0010902)3.16827478
41Hypokalemia (HP:0002900)3.15090241
42Decreased circulating renin level (HP:0003351)3.14362973
43Abnormality of midbrain morphology (HP:0002418)3.11095734
44Molar tooth sign on MRI (HP:0002419)3.11095734
45Hyperpituitarism (HP:0010514)3.07317816
46Abnormality of potassium homeostasis (HP:0011042)2.96016201
47Facial shape deformation (HP:0011334)2.91683701
48Potter facies (HP:0002009)2.91683701
49Congenital stationary night blindness (HP:0007642)2.87581432
50Hypercalciuria (HP:0002150)2.83913209
51Nephronophthisis (HP:0000090)2.82027630
52* Congenital sensorineural hearing impairment (HP:0008527)2.81949697
53Aplasia of the phalanges of the hand (HP:0009802)2.66149588
54Aplasia involving bones of the extremities (HP:0009825)2.66149588
55Aplasia involving bones of the upper limbs (HP:0009823)2.66149588
56* Coarse facial features (HP:0000280)2.65251506
57Tachypnea (HP:0002789)2.64534743
58Glomerulosclerosis (HP:0000096)2.60161046
59Macroglossia (HP:0000158)2.59727952
60Hyponatremia (HP:0002902)2.57811193
61Hypotension (HP:0002615)2.57675659
62Abnormality of glycine metabolism (HP:0010895)2.56575882
63Abnormality of serine family amino acid metabolism (HP:0010894)2.56575882
64Abnormality of the renal cortex (HP:0011035)2.55265189
65Vacuolated lymphocytes (HP:0001922)2.54148143
66Hyperkalemia (HP:0002153)2.53274456
67Abolished electroretinogram (ERG) (HP:0000550)2.52890434
68Abnormality of sodium homeostasis (HP:0010931)2.51985241
69Dehydration (HP:0001944)2.51516090
70Ketoacidosis (HP:0001993)2.50545000
71Focal motor seizures (HP:0011153)2.48028062
72Malnutrition (HP:0004395)2.47421571
73Adrenal overactivity (HP:0002717)2.43041011
74Type II lissencephaly (HP:0007260)2.38552629
75Abnormality of the renal medulla (HP:0100957)2.38442944
76Large for gestational age (HP:0001520)2.38377714
77Abnormality of nucleobase metabolism (HP:0010932)2.36828532
78Onycholysis (HP:0001806)2.36313509
79Widely patent fontanelles and sutures (HP:0004492)2.36230878
80Vascular calcification (HP:0004934)2.31755045
81Hyperventilation (HP:0002883)2.29819468
82Hypoplasia of the uterus (HP:0000013)2.29589040
83Cystic liver disease (HP:0006706)2.28395947
84Keratoconus (HP:0000563)2.27930771
85Increased corneal curvature (HP:0100692)2.27930771
86Renal tubular acidosis (HP:0001947)2.25770214
87Pendular nystagmus (HP:0012043)2.24385244
88Cerebral inclusion bodies (HP:0100314)2.23676772
89Agitation (HP:0000713)2.22500540
90Medial flaring of the eyebrow (HP:0010747)2.22119759
91Genetic anticipation (HP:0003743)2.21992405
92Abnormality of proline metabolism (HP:0010907)2.18099799
93Hydroxyprolinuria (HP:0003080)2.18099799
94Congenital, generalized hypertrichosis (HP:0004540)2.16288161
95Generalized aminoaciduria (HP:0002909)2.15829030
96Abnormality of the vitreous humor (HP:0004327)2.15670483
97Tubular atrophy (HP:0000092)2.13627138
98* Constipation (HP:0002019)2.12278029
99Chronic hepatic failure (HP:0100626)2.11448638
100Nephrolithiasis (HP:0000787)2.11111577
101Ketosis (HP:0001946)2.08901929
102Cardiovascular calcification (HP:0011915)2.08102404
103Abnormal rod and cone electroretinograms (HP:0008323)2.04869918
104Furrowed tongue (HP:0000221)2.04566730
105Genu varum (HP:0002970)2.04255400
106Ventricular fibrillation (HP:0001663)2.03444199
107Hypoplastic nipples (HP:0002557)2.02549502
108Hyperglycinemia (HP:0002154)2.02155963
109Abnormality of urine glucose concentration (HP:0011016)2.02125902
110Glycosuria (HP:0003076)2.02125902
111Urinary glycosaminoglycan excretion (HP:0003541)2.00358151
112Mucopolysacchariduria (HP:0008155)2.00358151
113Thyroid-stimulating hormone excess (HP:0002925)12.2035913
114* Goiter (HP:0000853)11.0359901
115Tubulointerstitial abnormality (HP:0001969)1.99595193
116Gaze-evoked nystagmus (HP:0000640)1.99161752
117Renal cortical cysts (HP:0000803)1.99031614
118Lymphangioma (HP:0100764)1.97672047
119Abnormal respiratory epithelium morphology (HP:0012253)1.97427284
120Abnormal respiratory motile cilium morphology (HP:0005938)1.97427284
121Decreased central vision (HP:0007663)1.96941727
122Nephrocalcinosis (HP:0000121)1.94906446
123Progressive cerebellar ataxia (HP:0002073)1.94485959
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93204126
125Attenuation of retinal blood vessels (HP:0007843)1.93080690
126Humeroradial synostosis (HP:0003041)1.92496459
127Synostosis involving the elbow (HP:0003938)1.92496459
128Confusion (HP:0001289)1.91476795
129* Thyroid carcinoma (HP:0002890)1.90725304
130Gait imbalance (HP:0002141)1.90005398
131Dysostosis multiplex (HP:0000943)1.89608038
132Chorioretinal atrophy (HP:0000533)1.85733009
133Hyperphosphatemia (HP:0002905)1.84801673
1343-Methylglutaconic aciduria (HP:0003535)1.84710812
135Neurofibrillary tangles (HP:0002185)1.84195258
136Umbilical hernia (HP:0001537)1.81875030
137Focal segmental glomerulosclerosis (HP:0000097)1.81634320
138Congenital primary aphakia (HP:0007707)1.81608983
139Inability to walk (HP:0002540)1.81389742
140Hyperphosphaturia (HP:0003109)1.79092586
141Abnormality of polysaccharide metabolism (HP:0011012)1.79013262
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79013262
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79013262
144Sensorimotor neuropathy (HP:0007141)1.77672869
145Sclerocornea (HP:0000647)1.76916663
146Abnormality of the middle phalanges of the toes (HP:0010183)1.76324944
147Rickets (HP:0002748)1.75669107
148Abnormality of the lower motor neuron (HP:0002366)1.73254142
149Absent/shortened dynein arms (HP:0200106)1.73228148
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.73228148
151Concave nail (HP:0001598)1.72910517
152Male pseudohermaphroditism (HP:0000037)1.72214087
153Abnormal urine phosphate concentration (HP:0012599)1.71429061
154Hypophosphatemia (HP:0002148)1.69903861
155Protuberant abdomen (HP:0001538)1.68949569
156Anencephaly (HP:0002323)1.68007973
157Steatorrhea (HP:0002570)1.67803179
158Genital tract atresia (HP:0001827)1.67438147
159Bicornuate uterus (HP:0000813)1.67065841
160Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.65734769
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.65669348
162Focal seizures (HP:0007359)1.65544430
163Long toe (HP:0010511)1.64396264
164Congenital hepatic fibrosis (HP:0002612)1.64184642
165Vaginal atresia (HP:0000148)1.62384916
166Abnormality of alanine metabolism (HP:0010916)1.62326343
167Hyperalaninemia (HP:0003348)1.62326343
168Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62326343
169Asplenia (HP:0001746)1.61826214
170Bradycardia (HP:0001662)1.60587746
171Prolonged QT interval (HP:0001657)1.60123146
172Nephrogenic diabetes insipidus (HP:0009806)1.60093898
173Astigmatism (HP:0000483)1.59930635
174Visceral angiomatosis (HP:0100761)1.59502286
175Polycythemia (HP:0001901)1.58676656
176Lethargy (HP:0001254)1.58438625
177Abnormal enzyme/coenzyme activity (HP:0012379)1.57105927
178Chondrocalcinosis (HP:0000934)1.56489521
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.56210817
180Abnormal ciliary motility (HP:0012262)1.55314072
181Aplasia/hypoplasia of the uterus (HP:0008684)1.54722828
182Fat malabsorption (HP:0002630)1.54585190
183Aplasia/Hypoplasia of the tibia (HP:0005772)1.54133914
184Syncope (HP:0001279)1.51120666
185Abnormal biliary tract physiology (HP:0012439)1.49122647
186Bile duct proliferation (HP:0001408)1.49122647
187Abnormality of the phalanges of the 2nd finger (HP:0009541)1.48863424
188Prenatal maternal abnormality (HP:0002686)1.48609044
189Postaxial foot polydactyly (HP:0001830)1.46335390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR15.97274427
2STK395.73451513
3WNK45.32154455
4NTRK33.79124593
5EPHA43.74316978
6GRK13.27891253
7ADRBK23.26533565
8BMPR1B3.22321384
9WNK33.18342573
10PINK12.96418988
11MAP3K92.62434172
12INSRR2.54956332
13CASK2.48311677
14EPHA22.38394595
15MAP4K22.37431335
16ZAK2.12407450
17MST42.03959625
18KSR22.00436753
19LMTK21.98560125
20RIPK41.95317055
21ACVR1B1.83853205
22TLK11.79114173
23FER1.78997457
24MAP3K21.70557686
25NUAK11.61605276
26MAPK131.53939955
27TIE11.50606509
28PTK2B1.48844529
29MAP3K131.48168800
30STK381.39708006
31TXK1.36959835
32AKT31.36543543
33DAPK21.33223343
34TAF11.27047967
35NME11.22356051
36ADRBK11.21088011
37KSR11.20691126
38MAPKAPK31.17519098
39SGK2231.16857435
40SGK4941.16857435
41MST1R1.14286232
42ARAF1.06198694
43CSNK1G21.05194267
44NTRK21.04473135
45NLK1.04315074
46DAPK11.04266998
47TGFBR11.00774726
48PTK20.99433222
49MINK10.97774239
50PRKCE0.96681919
51ERN10.96509218
52TGFBR20.95114790
53STK38L0.94088914
54MAP3K70.93355897
55MKNK20.90701752
56FRK0.88436149
57WNK10.88253291
58MAP3K120.87506282
59BCKDK0.84843909
60NTRK10.84170085
61MARK10.83118273
62DYRK20.78744113
63LRRK20.78692293
64MYLK0.75048498
65MAPKAPK50.73888708
66VRK10.72718167
67EPHB20.72477835
68CSNK1A10.72084441
69CAMKK20.71398560
70FGFR20.71355862
71TNIK0.71189717
72EPHB10.71183780
73PDPK10.70460384
74STK160.67410281
75EPHA30.66065364
76CSNK1G10.65274494
77STK30.64616815
78PDGFRA0.64285709
79RAF10.63903853
80PRKD20.63754808
81ILK0.63408256
82PKN10.62981794
83MAP3K10.62630948
84GRK60.61895859
85PAK40.61590177
86BRSK20.60978333
87TAOK30.60595797
88SGK30.59571413
89ERBB30.59552145
90RIPK10.59511331
91PDK20.59413421
92SGK10.59298636
93MUSK0.59034961
94CAMK2B0.57429211
95PRKACA0.54901097
96GRK50.54895334
97BMPR20.53761003
98SGK20.53435736
99MAP2K70.53189436
100PDGFRB0.52329552
101FGFR40.51745499
102MAP2K40.51466270
103PLK20.50716988
104ERBB20.50369470
105LATS10.50339717
106PDK30.49352806
107PDK40.49352806
108RPS6KA50.48714662
109PIK3CA0.47127846
110CDK50.46958708
111TRIM280.46515893
112CAMK10.45894974
113CSNK1G30.45789157
114MAP2K10.44602714
115PRPF4B0.44520173
116CAMK2A0.44422860
117FES0.43894246
118CAMKK10.43652647
119PTK60.43493419
120PRKCG0.42683565
121MAPK150.42647145
122PRKCI0.42357976
123CHUK0.41816080
124VRK20.41464049
125PDK10.40692131
126CCNB10.40646410
127GSK3A0.39940222
128SIK10.39612238
129IKBKB0.39224349
130STK240.38838688
131STK110.38739666
132DDR20.38097176
133DMPK0.37315010
134MAP2K60.37303247
135CSNK1A1L0.37164616
136PAK30.36706780
137FGR0.35977918
138PRKCA0.35871805
139PRKCQ0.35022089
140ROCK20.34758241
141PRKCZ0.34681592
142PNCK0.33963153
143PAK60.33890725
144RET0.32786389
145MET0.32344532
146MARK20.32045820
147MAP3K40.31406901
148MAP2K20.31263119
149TEC0.31255423
150CDK30.29934163
151DYRK1A0.29785464
152LATS20.29782045
153WEE10.29450400
154IGF1R0.28965735
155PHKG10.28297300
156PHKG20.28297300
157SCYL20.28145751
158CAMK1G0.26076266
159TRIB30.25938565

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053204.53526758
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.87963367
3Collecting duct acid secretion_Homo sapiens_hsa049662.75421123
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.60437987
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56729143
6Mineral absorption_Homo sapiens_hsa049782.53041925
7Tyrosine metabolism_Homo sapiens_hsa003502.27450890
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.19224733
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17861781
10Phototransduction_Homo sapiens_hsa047442.12020020
11Renin-angiotensin system_Homo sapiens_hsa046142.11363790
12Salivary secretion_Homo sapiens_hsa049701.95290442
13Oxidative phosphorylation_Homo sapiens_hsa001901.94050319
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.90284143
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86240228
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83109250
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82569487
18Linoleic acid metabolism_Homo sapiens_hsa005911.82549017
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74223198
20Butanoate metabolism_Homo sapiens_hsa006501.71995806
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70226355
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70171202
23Propanoate metabolism_Homo sapiens_hsa006401.67515019
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63677861
25Long-term potentiation_Homo sapiens_hsa047201.61048438
26Gastric acid secretion_Homo sapiens_hsa049711.58688312
27Bile secretion_Homo sapiens_hsa049761.57218541
28Synaptic vesicle cycle_Homo sapiens_hsa047211.56927116
29Nicotine addiction_Homo sapiens_hsa050331.53336430
30Vibrio cholerae infection_Homo sapiens_hsa051101.49003871
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47742490
32Protein export_Homo sapiens_hsa030601.45416307
33Ether lipid metabolism_Homo sapiens_hsa005651.44068579
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42987990
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41435683
36Selenocompound metabolism_Homo sapiens_hsa004501.38495215
37Sulfur metabolism_Homo sapiens_hsa009201.36451218
38Parkinsons disease_Homo sapiens_hsa050121.31071672
39Pyruvate metabolism_Homo sapiens_hsa006201.26667763
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24193291
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21644717
42Amphetamine addiction_Homo sapiens_hsa050311.19628276
43Fatty acid degradation_Homo sapiens_hsa000711.19359491
44Circadian entrainment_Homo sapiens_hsa047131.12960756
45Renin secretion_Homo sapiens_hsa049241.12212967
46Cardiac muscle contraction_Homo sapiens_hsa042601.12078643
47Tryptophan metabolism_Homo sapiens_hsa003801.07077175
48Peroxisome_Homo sapiens_hsa041461.06617248
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01700716
50Glutamatergic synapse_Homo sapiens_hsa047241.01686378
51Alzheimers disease_Homo sapiens_hsa050101.01123715
52* Thyroid hormone synthesis_Homo sapiens_hsa049181.00975201
53ABC transporters_Homo sapiens_hsa020100.98219268
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98004954
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97972997
56Basal transcription factors_Homo sapiens_hsa030220.96926388
57Chemical carcinogenesis_Homo sapiens_hsa052040.94166997
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93962826
59Other glycan degradation_Homo sapiens_hsa005110.93956462
60Protein digestion and absorption_Homo sapiens_hsa049740.92654727
61Cocaine addiction_Homo sapiens_hsa050300.91657628
62beta-Alanine metabolism_Homo sapiens_hsa004100.91645448
63Vitamin digestion and absorption_Homo sapiens_hsa049770.91588653
64Huntingtons disease_Homo sapiens_hsa050160.91259405
65Lysosome_Homo sapiens_hsa041420.90078824
66Arginine and proline metabolism_Homo sapiens_hsa003300.89982986
67Caffeine metabolism_Homo sapiens_hsa002320.89614727
68Olfactory transduction_Homo sapiens_hsa047400.88559156
69Taste transduction_Homo sapiens_hsa047420.87705540
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87416798
71Arachidonic acid metabolism_Homo sapiens_hsa005900.86910091
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86860829
73Pancreatic secretion_Homo sapiens_hsa049720.85605680
74Choline metabolism in cancer_Homo sapiens_hsa052310.84969084
75Arginine biosynthesis_Homo sapiens_hsa002200.84935333
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83572479
77Glycerolipid metabolism_Homo sapiens_hsa005610.80130460
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78716516
79GABAergic synapse_Homo sapiens_hsa047270.77448199
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76846469
81Nitrogen metabolism_Homo sapiens_hsa009100.76811286
82Fatty acid metabolism_Homo sapiens_hsa012120.75229465
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74744723
84Circadian rhythm_Homo sapiens_hsa047100.74237396
85Histidine metabolism_Homo sapiens_hsa003400.71219385
86Glutathione metabolism_Homo sapiens_hsa004800.70138062
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.66401589
88Tight junction_Homo sapiens_hsa045300.64840218
89Insulin secretion_Homo sapiens_hsa049110.64627088
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64585931
91RNA polymerase_Homo sapiens_hsa030200.64584815
92Regulation of autophagy_Homo sapiens_hsa041400.64580022
93Morphine addiction_Homo sapiens_hsa050320.64562904
94Carbon metabolism_Homo sapiens_hsa012000.63856027
95Oxytocin signaling pathway_Homo sapiens_hsa049210.63638376
96Retinol metabolism_Homo sapiens_hsa008300.62262693
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60754322
98Long-term depression_Homo sapiens_hsa047300.60712922
99Calcium signaling pathway_Homo sapiens_hsa040200.60338736
100Fat digestion and absorption_Homo sapiens_hsa049750.60016398
101Dopaminergic synapse_Homo sapiens_hsa047280.59189666
102Fructose and mannose metabolism_Homo sapiens_hsa000510.59131290
103Hedgehog signaling pathway_Homo sapiens_hsa043400.59010592
104Inositol phosphate metabolism_Homo sapiens_hsa005620.58836148
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.58066270
106cAMP signaling pathway_Homo sapiens_hsa040240.57769695
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57449976
108Homologous recombination_Homo sapiens_hsa034400.57235733
109PPAR signaling pathway_Homo sapiens_hsa033200.57184187
110Cholinergic synapse_Homo sapiens_hsa047250.56322304
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.56273946
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56178765
113Ovarian steroidogenesis_Homo sapiens_hsa049130.55266976
114GnRH signaling pathway_Homo sapiens_hsa049120.52768489
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52248724
116Estrogen signaling pathway_Homo sapiens_hsa049150.52210697
117Basal cell carcinoma_Homo sapiens_hsa052170.52115356
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52001188
119VEGF signaling pathway_Homo sapiens_hsa043700.51696753
120Gap junction_Homo sapiens_hsa045400.51589453
121Metabolic pathways_Homo sapiens_hsa011000.51565071
122Axon guidance_Homo sapiens_hsa043600.51056712
123ECM-receptor interaction_Homo sapiens_hsa045120.49713910
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48710720
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48436851
126Glioma_Homo sapiens_hsa052140.48434416
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48266602
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47851784
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47559736
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47101130
131Melanogenesis_Homo sapiens_hsa049160.45970835
132Dorso-ventral axis formation_Homo sapiens_hsa043200.45844760
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45667304
134Bladder cancer_Homo sapiens_hsa052190.45462073
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.43346563
136TGF-beta signaling pathway_Homo sapiens_hsa043500.43339279
137Rheumatoid arthritis_Homo sapiens_hsa053230.42716762
138Lysine degradation_Homo sapiens_hsa003100.41109364
139Starch and sucrose metabolism_Homo sapiens_hsa005000.39952525
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.39121563
141Serotonergic synapse_Homo sapiens_hsa047260.38576569
142Adherens junction_Homo sapiens_hsa045200.37884765
143Intestinal immune network for IgA production_Homo sapiens_hsa046720.37127019
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.36172640
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35910313
146Hippo signaling pathway_Homo sapiens_hsa043900.33919096
147Type II diabetes mellitus_Homo sapiens_hsa049300.33672031
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30897623
149One carbon pool by folate_Homo sapiens_hsa006700.30003114

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