SLC26A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell differentiation in thymus (GO:0033085)6.50947877
2transcytosis (GO:0045056)6.36201731
3glucocorticoid biosynthetic process (GO:0006704)6.25664815
4chondrocyte proliferation (GO:0035988)5.77432858
5negative regulation of keratinocyte proliferation (GO:0010839)5.59783168
6cellular glucuronidation (GO:0052695)5.28503871
7positive regulation of fatty acid beta-oxidation (GO:0032000)5.09967625
8positive regulation of T cell differentiation in thymus (GO:0033089)5.08625755
9cytidine deamination (GO:0009972)5.07689303
10cytidine metabolic process (GO:0046087)5.07689303
11cytidine catabolic process (GO:0006216)5.07689303
12UDP-N-acetylglucosamine metabolic process (GO:0006047)5.04310293
13uronic acid metabolic process (GO:0006063)4.93955551
14glucuronate metabolic process (GO:0019585)4.93955551
15regulation of vitamin metabolic process (GO:0030656)4.93264784
16intestinal epithelial cell development (GO:0060576)4.82570664
17epithelial cell-cell adhesion (GO:0090136)4.60994774
18sperm capacitation (GO:0048240)4.58364916
19renal system process involved in regulation of blood volume (GO:0001977)4.43741403
20intestinal absorption (GO:0050892)4.43673068
21positive regulation of epidermal cell differentiation (GO:0045606)4.41478452
22renal filtration (GO:0097205)4.34202906
23glomerular filtration (GO:0003094)4.31624143
24oligosaccharide biosynthetic process (GO:0009312)4.29251194
25negative regulation of macroautophagy (GO:0016242)4.23175637
26labyrinthine layer development (GO:0060711)4.12862027
27hepatocyte apoptotic process (GO:0097284)4.11232584
28bundle of His cell to Purkinje myocyte communication (GO:0086069)4.07775215
29positive regulation of respiratory burst (GO:0060267)4.04083121
30somite development (GO:0061053)4.01616710
31glucocorticoid metabolic process (GO:0008211)3.99777324
32maintenance of gastrointestinal epithelium (GO:0030277)3.94311750
33embryonic camera-type eye morphogenesis (GO:0048596)3.93231711
34lipid translocation (GO:0034204)3.89672471
35phospholipid translocation (GO:0045332)3.89672471
36positive regulation of epidermis development (GO:0045684)3.88387422
37regulation of cholesterol homeostasis (GO:2000188)3.86845016
38positive regulation of fatty acid oxidation (GO:0046321)3.86819241
39bone resorption (GO:0045453)3.85923048
40extracellular matrix assembly (GO:0085029)3.85059866
41gap junction assembly (GO:0016264)3.76712336
42polyketide metabolic process (GO:0030638)3.71465690
43doxorubicin metabolic process (GO:0044598)3.71465690
44daunorubicin metabolic process (GO:0044597)3.71465690
45regulation of fatty acid beta-oxidation (GO:0031998)3.69529117
46negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.67526107
47negative regulation of alpha-beta T cell differentiation (GO:0046639)3.66217222
48regulation of intracellular pH (GO:0051453)3.65943367
49regulation of autophagic vacuole assembly (GO:2000785)3.64421513
50vitamin A metabolic process (GO:0006776)3.64205140
51ethanol oxidation (GO:0006069)3.58372770
52nucleotide-sugar biosynthetic process (GO:0009226)3.57261335
53regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.54224856
54endocrine process (GO:0050886)3.54224856
55regulation of systemic arterial blood pressure by hormone (GO:0001990)3.54224856
56pyrimidine ribonucleoside catabolic process (GO:0046133)3.53460862
57O-glycan processing (GO:0016266)3.49704248
58positive regulation of chondrocyte differentiation (GO:0032332)3.45567095
59regulation of viral release from host cell (GO:1902186)3.44918928
60heterochromatin organization (GO:0070828)3.41526252
61drug transmembrane transport (GO:0006855)3.40580192
62bile acid and bile salt transport (GO:0015721)3.37066496
63hypotonic response (GO:0006971)3.34755308
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.34342610
65positive regulation of glycoprotein biosynthetic process (GO:0010560)3.33215769
66hemidesmosome assembly (GO:0031581)3.32521260
67regulation of cellular pH (GO:0030641)3.32502358
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30482053
69negative regulation of anoikis (GO:2000811)3.29800085
70negative regulation of myotube differentiation (GO:0010832)3.29754171
71regulation of vacuole organization (GO:0044088)3.27389421
72negative regulation of protein tyrosine kinase activity (GO:0061099)3.27371246
73receptor guanylyl cyclase signaling pathway (GO:0007168)3.25400122
74positive regulation of pseudopodium assembly (GO:0031274)3.23467100
75regulation of transforming growth factor beta1 production (GO:0032908)3.23044785
76regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.22443706
77auditory receptor cell differentiation (GO:0042491)3.22134886
78actin filament depolymerization (GO:0030042)3.18854966
79notochord development (GO:0030903)3.17029757
80one-carbon metabolic process (GO:0006730)3.16788606
81regulation of guanylate cyclase activity (GO:0031282)3.15512952
82cellular response to vitamin D (GO:0071305)3.15393234
83sulfur amino acid catabolic process (GO:0000098)3.14889641
84renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.14048974
85desmosome organization (GO:0002934)3.13688881
86regulation of water loss via skin (GO:0033561)3.09508205
87smooth muscle tissue development (GO:0048745)3.08697660
88intermediate filament organization (GO:0045109)3.08216703
89regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06889727
90flavonoid metabolic process (GO:0009812)3.05736136
91regulation of chemokine secretion (GO:0090196)3.04793706
92cGMP-mediated signaling (GO:0019934)3.04269464
93positive regulation of glycoprotein metabolic process (GO:1903020)3.01433488
94regulation of keratinocyte proliferation (GO:0010837)2.98945971
95Golgi transport vesicle coating (GO:0048200)2.97850701
96COPI coating of Golgi vesicle (GO:0048205)2.97850701
97regulation of pH (GO:0006885)2.97123467
98embryonic eye morphogenesis (GO:0048048)2.96855735
99establishment of skin barrier (GO:0061436)2.95152529
100receptor recycling (GO:0001881)2.95109129
101regulation of systemic arterial blood pressure (GO:0003073)2.93936378
102excretion (GO:0007588)2.92176955
103negative regulation of organelle assembly (GO:1902116)2.91839932
104Leydig cell differentiation (GO:0033327)2.89423261
105keratinocyte development (GO:0003334)2.87471730
106drug transport (GO:0015893)2.87388055
107sphingomyelin metabolic process (GO:0006684)2.87138742
108ethanol metabolic process (GO:0006067)2.85359092
109positive regulation of guanylate cyclase activity (GO:0031284)2.84872519
110regulation of pseudopodium assembly (GO:0031272)2.84475783
111regulation of T cell differentiation in thymus (GO:0033081)2.84138699
112regulation of epidermis development (GO:0045682)2.82124787
113epithelial structure maintenance (GO:0010669)2.81783259
114trophectodermal cell differentiation (GO:0001829)2.80569001
115ventricular cardiac muscle cell action potential (GO:0086005)2.80396286
116cellular response to hepatocyte growth factor stimulus (GO:0035729)2.79820309
117response to hepatocyte growth factor (GO:0035728)2.79820309
118hormone catabolic process (GO:0042447)2.77629174
119intestinal cholesterol absorption (GO:0030299)2.77473103
120cell differentiation involved in embryonic placenta development (GO:0060706)2.76634778
121pyrimidine-containing compound transmembrane transport (GO:0072531)2.74580066
122regulation of membrane lipid distribution (GO:0097035)2.74150743
123negative regulation of epidermis development (GO:0045683)2.74001350
124progesterone metabolic process (GO:0042448)2.73065712
125sodium ion homeostasis (GO:0055078)2.71099708
126* sulfur compound transport (GO:0072348)2.70196874
127nucleotide-sugar metabolic process (GO:0009225)2.69551170
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68300509
129positive regulation of cartilage development (GO:0061036)2.68209782
130cellular monovalent inorganic cation homeostasis (GO:0030004)2.67963412
131mitotic G2 DNA damage checkpoint (GO:0007095)2.67647281
132vitamin transmembrane transport (GO:0035461)2.66551188
133fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66071534
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65717030
135regulation of respiratory burst (GO:0060263)2.65504657
136regulation of anoikis (GO:2000209)2.64629552
137monovalent inorganic cation homeostasis (GO:0055067)2.64261685
138establishment of endothelial barrier (GO:0061028)2.64193222
139parturition (GO:0007567)2.64033080
140negative regulation of epidermal cell differentiation (GO:0045605)2.63730285
141mitotic G2/M transition checkpoint (GO:0044818)2.61734476
142regulation of pigment cell differentiation (GO:0050932)2.61626725
143thrombin receptor signaling pathway (GO:0070493)2.60576254
144regulation of epidermal cell differentiation (GO:0045604)2.59769289
145early endosome to late endosome transport (GO:0045022)2.59109776
146positive regulation of Cdc42 GTPase activity (GO:0043089)2.58650988
147negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.58188449
148* sulfate transport (GO:0008272)2.57196854
149positive regulation of keratinocyte differentiation (GO:0045618)2.57176731
150regulation of fatty acid oxidation (GO:0046320)2.56770460
151branching involved in labyrinthine layer morphogenesis (GO:0060670)2.56749827
152positive regulation of smoothened signaling pathway (GO:0045880)2.56668536
153cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.55748092
154cell adhesion mediated by integrin (GO:0033627)2.55739549
155* sulfate transmembrane transport (GO:1902358)2.55629412
156digestive system process (GO:0022600)2.54580954
157diol metabolic process (GO:0034311)2.53867828
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53274049
159regulation of cGMP biosynthetic process (GO:0030826)2.52792763
160maternal process involved in female pregnancy (GO:0060135)2.51617934
161striated muscle atrophy (GO:0014891)2.48175939
162regulation of developmental pigmentation (GO:0048070)2.47000014
163keratan sulfate catabolic process (GO:0042340)2.44291357
164bicarbonate transport (GO:0015701)2.43457097
165regulation of collagen biosynthetic process (GO:0032965)2.43224362
166negative regulation of alpha-beta T cell activation (GO:0046636)2.41918367
167angiotensin maturation (GO:0002003)2.39268283
168branching involved in mammary gland duct morphogenesis (GO:0060444)2.37925357
169regulation of chondrocyte differentiation (GO:0032330)2.37761561
170GDP-mannose metabolic process (GO:0019673)2.36147592
171calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.29456101
172negative regulation of chemokine production (GO:0032682)2.27708422
173negative regulation of cell cycle G2/M phase transition (GO:1902750)2.27514452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.34884941
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.97005448
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.72280371
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65029961
5* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.57634877
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50603696
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.45350615
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.45350615
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.45350615
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.34672226
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34276268
12GATA6_25053715_ChIP-Seq_YYC3_Human2.28908171
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.27879037
14FOXO3_23340844_ChIP-Seq_DLD1_Human2.19571356
15GATA4_25053715_ChIP-Seq_YYC3_Human2.16148789
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13675369
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09758915
18* SOX2_20726797_ChIP-Seq_SW620_Human2.00399883
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98974738
20CLOCK_20551151_ChIP-Seq_293T_Human1.94386118
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92486787
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84379999
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.83225420
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.80021134
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79474293
26FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.75664811
27FOXM1_26456572_ChIP-Seq_MCF-7_Human1.73528417
28ZNF263_19887448_ChIP-Seq_K562_Human1.73266625
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.72575515
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.71818531
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71492801
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70825390
33* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.68521822
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68452166
35CDX2_22108803_ChIP-Seq_LS180_Human1.66123428
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.65650438
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65038873
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63592571
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.60388886
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60018580
41KLF5_25053715_ChIP-Seq_YYC3_Human1.55821827
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54441040
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54239895
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54239895
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52968607
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52118126
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.51458037
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51439475
49FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.50436250
50* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49339124
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.48691171
52VDR_22108803_ChIP-Seq_LS180_Human1.47457365
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46767823
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.46624954
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.45333563
56RACK7_27058665_Chip-Seq_MCF-7_Human1.43606556
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.42659978
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41309448
59AHR_22903824_ChIP-Seq_MCF-7_Human1.40465826
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38689123
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.34793059
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33736300
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33568299
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33568299
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33166951
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32667063
67* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32598612
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29907424
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27057507
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26758653
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26452458
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.25579757
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24994110
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23831771
75TP63_23658742_ChIP-Seq_EP156T_Human1.23773394
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22956001
77* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20799151
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19339093
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18595572
80* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18522967
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18161345
82TP53_16413492_ChIP-PET_HCT116_Human1.18091294
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.17446794
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15138198
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.14630722
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14537351
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14519150
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13697278
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.13449767
90GATA3_24758297_ChIP-Seq_MCF-7_Human1.12752557
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12750420
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12396042
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11738049
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11073317
95ATF3_27146783_Chip-Seq_COLON_Human1.10968884
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10899095
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09073061
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08974721
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08234401
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07623900
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06963451
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06376432
103E2F7_22180533_ChIP-Seq_HELA_Human1.05794459
104* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05699218
105* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04744060
106RXR_22108803_ChIP-Seq_LS180_Human1.04529675
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03643245
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03500989
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02333565
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02318928
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02166513
112MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01892884
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01739221
114VDR_24787735_ChIP-Seq_THP-1_Human1.00909506
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00036103
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99579139
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98052000
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97624663
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97551938
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.97510672
121BRD4_25478319_ChIP-Seq_HGPS_Human0.97095503
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.97058895
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97033129
124NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96960435
125IRF8_21731497_ChIP-ChIP_J774_Mouse0.94599823
126VDR_24763502_ChIP-Seq_THP-1_Human0.94244695
127GATA2_19941826_ChIP-Seq_K562_Human0.94129237
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.93201853
129TCF7_22412390_ChIP-Seq_EML_Mouse0.93163698
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92226685
131AR_21909140_ChIP-Seq_LNCAP_Human0.91461643
132RUNX1_22412390_ChIP-Seq_EML_Mouse0.90348256
133GATA1_22025678_ChIP-Seq_K562_Human0.90125006
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.89856490
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.89251985
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.89251985
137* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89092190
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88497526
139* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88391588
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86917856
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86591852
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85780252
143NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84860543
144CJUN_26792858_Chip-Seq_BT549_Human0.83729320
145ELF5_23300383_ChIP-Seq_T47D_Human0.83109927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.39758426
2MP0010234_abnormal_vibrissa_follicle5.30559301
3MP0002139_abnormal_hepatobiliary_system4.38230568
4MP0004264_abnormal_extraembryonic_tissu3.66216394
5MP0004043_abnormal_pH_regulation3.62411056
6MP0005377_hearing/vestibular/ear_phenot3.15126021
7MP0003878_abnormal_ear_physiology3.15126021
8MP0002009_preneoplasia2.76483898
9MP0000462_abnormal_digestive_system2.72318644
10MP0002822_catalepsy2.69677374
11MP0003705_abnormal_hypodermis_morpholog2.69379632
12MP0010352_gastrointestinal_tract_polyps2.56666811
13MP0005409_darkened_coat_color2.47919603
14MP0003868_abnormal_feces_composition2.44834457
15MP0003866_abnormal_defecation2.26614926
16MP0001666_abnormal_nutrient_absorption2.25929401
17MP0009780_abnormal_chondrocyte_physiolo2.22653450
18MP0005167_abnormal_blood-brain_barrier2.10320413
19MP0004147_increased_porphyrin_level2.08846357
20MP0002254_reproductive_system_inflammat2.07585328
21MP0000490_abnormal_crypts_of2.00885817
22MP0010155_abnormal_intestine_physiology1.96479585
23MP0003566_abnormal_cell_adhesion1.89972061
24MP0001873_stomach_inflammation1.86174886
25MP0005257_abnormal_intraocular_pressure1.79469983
26MP0000477_abnormal_intestine_morphology1.76037320
27MP0009379_abnormal_foot_pigmentation1.74835304
28MP0003315_abnormal_perineum_morphology1.72285258
29MP0009053_abnormal_anal_canal1.72094946
30MP0005365_abnormal_bile_salt1.60969240
31MP0005381_digestive/alimentary_phenotyp1.59476173
32MP0002098_abnormal_vibrissa_morphology1.59300274
33MP0004947_skin_inflammation1.56691224
34MP0002234_abnormal_pharynx_morphology1.54148993
35MP0008438_abnormal_cutaneous_collagen1.50367945
36MP0003300_gastrointestinal_ulcer1.49803426
37MP0003045_fibrosis1.45874487
38MP0010678_abnormal_skin_adnexa1.45739548
39MP0001663_abnormal_digestive_system1.44182799
40MP0005636_abnormal_mineral_homeostasis1.40300198
41MP0000762_abnormal_tongue_morphology1.40161267
42MP0010368_abnormal_lymphatic_system1.37980904
43MP0002796_impaired_skin_barrier1.36796780
44MP0000467_abnormal_esophagus_morphology1.36274144
45MP0009384_cardiac_valve_regurgitation1.34229939
46MP0001849_ear_inflammation1.25263642
47MP0003453_abnormal_keratinocyte_physiol1.23803699
48MP0005310_abnormal_salivary_gland1.21482039
49MP0009840_abnormal_foam_cell1.21124893
50MP0004019_abnormal_vitamin_homeostasis1.19467705
51MP0000013_abnormal_adipose_tissue1.15843862
52MP0000537_abnormal_urethra_morphology1.14424294
53* MP0000163_abnormal_cartilage_morphology1.11182295
54MP0005670_abnormal_white_adipose1.09898943
55MP0002896_abnormal_bone_mineralization1.09685174
56MP0001216_abnormal_epidermal_layer1.06763546
57MP0005076_abnormal_cell_differentiation1.06149874
58MP0003011_delayed_dark_adaptation1.05676943
59MP0005508_abnormal_skeleton_morphology1.04928727
60MP0008875_abnormal_xenobiotic_pharmacok1.04601208
61MP0002282_abnormal_trachea_morphology1.03145389
62MP0003436_decreased_susceptibility_to1.02391075
63MP0002277_abnormal_respiratory_mucosa1.01353085
64MP0008004_abnormal_stomach_pH0.99937199
65MP0006054_spinal_hemorrhage0.99815333
66MP0000377_abnormal_hair_follicle0.99267428
67MP0004272_abnormal_basement_membrane0.98679811
68MP0002060_abnormal_skin_morphology0.97778479
69MP0003252_abnormal_bile_duct0.96488145
70MP0005367_renal/urinary_system_phenotyp0.95085538
71MP0000516_abnormal_urinary_system0.95085538
72MP0004782_abnormal_surfactant_physiolog0.94542967
73MP0003937_abnormal_limbs/digits/tail_de0.94367982
74MP0000230_abnormal_systemic_arterial0.94247258
75MP0005390_skeleton_phenotype0.94189408
76MP0004134_abnormal_chest_morphology0.93187833
77MP0003941_abnormal_skin_development0.93011622
78MP0005360_urolithiasis0.91273847
79MP0002148_abnormal_hypersensitivity_rea0.90999521
80MP0002877_abnormal_melanocyte_morpholog0.90638685
81MP0001835_abnormal_antigen_presentation0.89966490
82MP0006082_CNS_inflammation0.89814142
83MP0005501_abnormal_skin_physiology0.88580203
84MP0000678_abnormal_parathyroid_gland0.87573872
85MP0001879_abnormal_lymphatic_vessel0.87435727
86MP0009643_abnormal_urine_homeostasis0.87109366
87MP0005408_hypopigmentation0.87102723
88MP0002136_abnormal_kidney_physiology0.86279066
89MP0005023_abnormal_wound_healing0.85661581
90MP0003183_abnormal_peptide_metabolism0.85021545
91MP0005165_increased_susceptibility_to0.83720203
92MP0009250_abnormal_appendicular_skeleto0.83502722
93MP0005666_abnormal_adipose_tissue0.83159947
94MP0000432_abnormal_head_morphology0.82954556
95MP0002233_abnormal_nose_morphology0.82625696
96MP0004185_abnormal_adipocyte_glucose0.81561688
97MP0001765_abnormal_ion_homeostasis0.81040126
98MP0005166_decreased_susceptibility_to0.80930871
99MP0000613_abnormal_salivary_gland0.79817452
100* MP0002115_abnormal_skeleton_extremities0.78981890
101MP0002166_altered_tumor_susceptibility0.78878735
102* MP0002113_abnormal_skeleton_development0.77153172
103* MP0003795_abnormal_bone_structure0.76445029
104MP0010386_abnormal_urinary_bladder0.76399520
105MP0005275_abnormal_skin_tensile0.75559547
106MP0003191_abnormal_cellular_cholesterol0.74264650
107MP0005595_abnormal_vascular_smooth0.73132876
108MP0005451_abnormal_body_composition0.73072464
109MP0002006_tumorigenesis0.72919900
110MP0001664_abnormal_digestion0.72850226
111MP0001533_abnormal_skeleton_physiology0.71704637
112MP0000470_abnormal_stomach_morphology0.71426793
113MP0005085_abnormal_gallbladder_physiolo0.70748303
114MP0002933_joint_inflammation0.70506405
115MP0001881_abnormal_mammary_gland0.69277970
116MP0000383_abnormal_hair_follicle0.68587832
117MP0000627_abnormal_mammary_gland0.68009813
118MP0001756_abnormal_urination0.67262517
119MP0003950_abnormal_plasma_membrane0.67193457
120MP0001790_abnormal_immune_system0.66909286
121MP0005387_immune_system_phenotype0.66909286
122MP0009785_altered_susceptibility_to0.66219613
123MP0002452_abnormal_antigen_presenting0.65774130
124MP0002111_abnormal_tail_morphology0.65405670
125MP0000465_gastrointestinal_hemorrhage0.65369909
126MP0002086_abnormal_extraembryonic_tissu0.64896795
127MP0002138_abnormal_hepatobiliary_system0.64466150
128MP0001191_abnormal_skin_condition0.64151605
129MP0003091_abnormal_cell_migration0.63705401
130MP0003828_pulmonary_edema0.61539914
131MP0004484_altered_response_of0.61252174
132MP0000647_abnormal_sebaceous_gland0.60708174
133MP0001188_hyperpigmentation0.59151829
134MP0003724_increased_susceptibility_to0.58393930
135MP0004858_abnormal_nervous_system0.57733234
136MP0010771_integument_phenotype0.57583229
137MP0000566_synostosis0.55263012
138MP0000538_abnormal_urinary_bladder0.55192721

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)7.38047950
2Abnormality of renin-angiotensin system (HP:0000847)7.08419405
3Cupped ribs (HP:0000887)6.73599553
4Hyperaldosteronism (HP:0000859)6.18409917
5Abnormality of the 1st metacarpal (HP:0010009)5.27420661
6Abnormality of carpal bone ossification (HP:0006257)5.25729886
7Abnormality of the proximal phalanges of the hand (HP:0009834)5.21951107
8Abnormality of the phalanges of the hallux (HP:0010057)4.61783748
9Alkalosis (HP:0001948)4.59329988
10Abnormal tarsal ossification (HP:0008369)4.47824532
11Hyponatremia (HP:0002902)4.43634844
12Abnormality of the 2nd finger (HP:0004100)4.39839600
13Abnormal ossification of hand bones (HP:0005921)4.30841583
14Abnormal hand bone ossification (HP:0010660)4.27898435
15* Abnormality of the distal phalanx of the thumb (HP:0009617)4.21500900
16Short phalanx of the thumb (HP:0009660)3.99618916
17Posterior subcapsular cataract (HP:0007787)3.88170343
18Intrahepatic cholestasis (HP:0001406)3.82267724
19* Flat acetabular roof (HP:0003180)3.77377986
20Hypokalemia (HP:0002900)3.74300426
21Conjugated hyperbilirubinemia (HP:0002908)3.73663757
22Abnormality of the middle phalanges of the toes (HP:0010183)3.66365416
23Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.64632690
24Relative macrocephaly (HP:0004482)3.61637241
25Abnormality of potassium homeostasis (HP:0011042)3.58282500
26Genu varum (HP:0002970)3.56525080
27Abnormal biliary tract morphology (HP:0012440)3.56083604
28Abnormal foot bone ossification (HP:0010675)3.55058207
29Right ventricular cardiomyopathy (HP:0011663)3.44151246
30Epiphyseal dysplasia (HP:0002656)3.41270473
31Short humerus (HP:0005792)3.32339488
32Abnormality of sodium homeostasis (HP:0010931)3.31622231
33Osteolytic defects of the hand bones (HP:0009699)3.25841064
34Osteolytic defects of the phalanges of the hand (HP:0009771)3.25841064
35Abnormality of monocarboxylic acid metabolism (HP:0010996)3.23601439
36Hyperkalemia (HP:0002153)3.19679330
37Broad palm (HP:0001169)3.18592174
38Coxa vara (HP:0002812)3.07260989
39Adrenal overactivity (HP:0002717)3.06715924
40Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.02791083
41* Short middle phalanx of finger (HP:0005819)3.00853043
42Aplasia/hypoplasia of the humerus (HP:0006507)2.98993326
43Short femoral neck (HP:0100864)2.98283001
44Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.95807137
45Short hallux (HP:0010109)2.94182530
46Hypoplastic ischia (HP:0003175)2.91599309
47Renal tubular acidosis (HP:0001947)2.87165019
48* Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.83833836
49* Irregular epiphyses (HP:0010582)2.78740801
50Delayed epiphyseal ossification (HP:0002663)2.78719921
51Flared iliac wings (HP:0002869)2.76973005
52Absent phalangeal crease (HP:0006109)2.75877677
53Ovoid vertebral bodies (HP:0003300)2.73804354
54Aplasia/Hypoplasia of the hallux (HP:0008362)2.70207447
55Hyperactive renin-angiotensin system (HP:0000841)2.68647695
56Ileus (HP:0002595)2.64769170
57* Abdominal distention (HP:0003270)2.62593236
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58583975
59Severe short stature (HP:0003510)2.57577838
60Short tibia (HP:0005736)2.56299618
61Renal salt wasting (HP:0000127)2.55919552
62Micronodular cirrhosis (HP:0001413)2.54540708
63Subcapsular cataract (HP:0000523)2.54240911
64Vitreoretinal degeneration (HP:0000655)2.53289566
65Cone-rod dystrophy (HP:0000548)2.51787584
66Pili torti (HP:0003777)2.50164529
67Focal segmental glomerulosclerosis (HP:0000097)2.49271234
68* Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.48382971
69* Abnormality of femoral epiphyses (HP:0006499)2.48382971
70Abnormality of the ischium (HP:0003174)2.48109325
71Chronic diarrhea (HP:0002028)2.43887288
72* Abnormality of the epiphysis of the femoral head (HP:0010574)2.42141683
73Dehydration (HP:0001944)2.41037254
74Shawl scrotum (HP:0000049)2.38697546
75Hemorrhage of the eye (HP:0011885)2.37839449
76Metaphyseal cupping (HP:0003021)2.35616264
77Thin bony cortex (HP:0002753)2.33505893
78* Symphalangism affecting the phalanges of the hand (HP:0009773)2.31501822
79Rectal prolapse (HP:0002035)2.30494570
80* Aplasia/hypoplasia of the femur (HP:0005613)2.29821893
81Pustule (HP:0200039)2.27551289
82Down-sloping shoulders (HP:0200021)2.26988319
83Small epiphyses (HP:0010585)2.24726740
84Fat malabsorption (HP:0002630)2.23445712
85Hypoplastic iliac wings (HP:0002866)2.21817885
86Abnormal finger flexion creases (HP:0006143)2.21632054
87Mildly elevated creatine phosphokinase (HP:0008180)2.21477054
88Fragile nails (HP:0001808)2.19407491
89Aplasia/Hypoplasia of the tibia (HP:0005772)2.18645741
90Petechiae (HP:0000967)2.18255197
91Palpitations (HP:0001962)2.17301322
92* Abnormality of the femoral head (HP:0003368)2.17061273
93Woolly hair (HP:0002224)2.15954169
94* Lumbar hyperlordosis (HP:0002938)2.13252556
95* Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.12359127
96Abnormality of small intestinal villus morphology (HP:0011472)2.12254006
97Villous atrophy (HP:0011473)2.12254006
98Cervical subluxation (HP:0003308)2.12006029
99Neoplasm of the rectum (HP:0100743)2.09440330
100Hyperparathyroidism (HP:0000843)2.07094721
101Abnormality of chloride homeostasis (HP:0011422)2.05591849
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05393406
103Protuberant abdomen (HP:0001538)2.04578388
104* Hypoplastic ilia (HP:0000946)2.03893746
105Tetraparesis (HP:0002273)2.02817941
106Enlarged epiphyses (HP:0010580)2.01319361
107Milia (HP:0001056)2.00556232
108Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.99946289
109Neoplasm of the small intestine (HP:0100833)1.99661088
110Abnormal hair laboratory examination (HP:0003328)1.98710650
111Short nail (HP:0001799)1.95508603
112Hydroxyprolinuria (HP:0003080)1.94878735
113Abnormality of proline metabolism (HP:0010907)1.94878735
114Glomerulosclerosis (HP:0000096)1.94721798
115Atrophic scars (HP:0001075)1.94047682
116Metaphyseal irregularity (HP:0003025)1.92801084
117Syncope (HP:0001279)1.92465903
118Cheilitis (HP:0100825)1.90217613
119Abnormality of the vitamin B12 metabolism (HP:0004341)1.90011716
120Cardiovascular calcification (HP:0011915)1.89203344
121Increased density of long bones (HP:0006392)1.88353614
122* Abnormality of the middle phalanges of the hand (HP:0009833)1.87996875
123Malnutrition (HP:0004395)1.86790627
124Biliary tract neoplasm (HP:0100574)1.86787933
125Abnormality of the epiphyses of the hand (HP:0005924)1.86389948
126Abnormality of the pubic bones (HP:0003172)1.84013350
127Aortic aneurysm (HP:0004942)1.83045917
128Vascular calcification (HP:0004934)1.82782038
129Abnormality of the distal phalanges of the toes (HP:0010182)1.82672950
130Autoimmune thrombocytopenia (HP:0001973)1.82618083
131* Flat capital femoral epiphysis (HP:0003370)1.81054532
132Beaking of vertebral bodies (HP:0004568)1.80273226
133Ulnar bowing (HP:0003031)1.80207246
134Congenital sensorineural hearing impairment (HP:0008527)1.80183376
135Aortic dissection (HP:0002647)1.79082716
136Hematochezia (HP:0002573)1.77903574
137Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76347537
138Hypoplastic scapulae (HP:0000882)1.76347537
139Bone pain (HP:0002653)1.72255898
140Abnormality of vitamin B metabolism (HP:0004340)1.72215144
141Curly hair (HP:0002212)1.70449792
142Blepharitis (HP:0000498)1.69627775
143Abnormality of the humerus (HP:0003063)1.69523756
144Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.68761764
145Metabolic alkalosis (HP:0200114)1.67018335
146* Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.66771999
147Breast hypoplasia (HP:0003187)1.65637646
148Abnormality of the fibula (HP:0002991)1.65443562
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65188625
150Tibial bowing (HP:0002982)1.63743772
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.62435219
152Symptomatic seizures (HP:0011145)1.61849217
153Ankyloglossia (HP:0010296)1.61312623
154Hypotension (HP:0002615)1.61156991
155Bilateral sensorineural hearing impairment (HP:0008619)1.60386478
156Abnormality of vitamin metabolism (HP:0100508)1.57306079
157Coarse hair (HP:0002208)1.56089914
158Abnormality of the gastric mucosa (HP:0004295)1.54154698
159Wormian bones (HP:0002645)1.52093758
160Distal lower limb amyotrophy (HP:0008944)1.51525332
161Spinal cord lesions (HP:0100561)1.51504607
162Syringomyelia (HP:0003396)1.51504607
163Amelogenesis imperfecta (HP:0000705)1.51449035
164Abnormal pancreas size (HP:0012094)1.51190979
165Conjunctival telangiectasia (HP:0000524)1.50586017
166Hyperammonemia (HP:0001987)1.50179212
167Periodontitis (HP:0000704)1.50077585
168Hypoplasia of dental enamel (HP:0006297)1.49248240
169Arterial tortuosity (HP:0005116)1.48435633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK39.24938824
2ACVR1B5.22513885
3MST1R4.92289260
4EPHB23.77109569
5CDK123.32632598
6PIK3CA3.01072269
7STK392.55332711
8MST42.29783317
9PDK22.24940521
10RIPK12.22634028
11FRK2.12327917
12GRK62.06186374
13PRKG22.01807067
14MAP2K21.96508331
15MET1.88728281
16ERN11.83967477
17STK101.80558274
18DDR21.72881546
19EPHA21.71446209
20TGFBR21.59377864
21MAP3K121.58751439
22MATK1.50409067
23GRK11.48587649
24PTK61.41280332
25MAP3K21.26442636
26MAP3K141.23763867
27SCYL21.22181576
28OXSR11.18969142
29PAK41.14819914
30TAOK11.06957358
31LMTK20.94739504
32CSF1R0.93195160
33NUAK10.90730189
34ICK0.89063223
35FGFR30.88845199
36LATS10.87435337
37NEK60.87026614
38PTK20.86505659
39CSK0.86171958
40MAP3K30.84887988
41TTK0.84120773
42TRIB30.80839198
43ITK0.78244629
44BRSK20.74765024
45SIK10.72765087
46LATS20.71209877
47TESK10.71134220
48CDK90.70732418
49MAP3K80.69803082
50MOS0.69733877
51CHUK0.69362274
52MAPK70.68275522
53STK30.68091081
54MAP2K10.66439272
55ABL20.66402684
56KSR20.66365515
57GRK50.66107652
58CAMK1D0.64710159
59NME10.64270601
60ERBB20.64232720
61BCR0.63495846
62ERBB30.63310718
63MAPKAPK30.62324786
64PDPK10.61273818
65RIPK40.60808565
66AURKB0.60514973
67MAP3K100.60345371
68RET0.59800990
69CAMK2D0.59757630
70MAP3K70.57705628
71CDK70.55017006
72TYK20.52698797
73TIE10.52683729
74NTRK10.51601105
75DMPK0.50390306
76CDK60.50231162
77RPS6KB20.50048319
78BMPR20.49518372
79WNK10.49208397
80PDGFRB0.49185209
81PAK20.49117998
82PRKAA20.48796282
83WNK40.48348843
84NEK90.48172414
85IKBKB0.47436354
86PBK0.46600089
87FLT30.46409214
88NME20.44787515
89CDC42BPA0.44329668
90EIF2AK30.42682081
91ERBB40.42650538
92MYLK0.41239825
93MAPK110.40757531
94ADRBK20.39959341
95JAK10.38243909
96STK240.37886563
97EPHB10.37866264
98GSK3A0.37343632
99AKT30.36128706
100TRPM70.35406070
101PIM20.34826389
102MAP3K10.34486095
103IRAK30.34247306
104NLK0.34024703
105MELK0.33518222
106BMX0.33385446
107MTOR0.32417170
108MAP3K130.31999989
109PRKCI0.31801416
110PDGFRA0.31645454
111EEF2K0.31575754
112EPHA30.31324957
113TYRO30.31323224
114RPS6KA20.31180887
115TTN0.30493297
116MAPKAPK20.30363318
117IGF1R0.29687147
118ZAK0.29422746
119AKT20.28843124
120STK38L0.28658436
121YES10.27865623
122JAK30.27400065
123NEK20.27043080
124PDK10.26907471
125LRRK20.26292594
126FGFR40.26017468
127FGFR10.25272843
128RPS6KB10.24469675
129SRC0.24304169
130EIF2AK20.24097318
131ADRBK10.23581107
132PRKCQ0.23402821
133FER0.23290743
134CLK10.23241263
135NEK10.21761360
136MAP3K60.21303708
137SMG10.20995387
138PRKACG0.19193694
139PKN20.17869498
140CSNK1A10.17857797
141SGK30.17198340
142ROCK10.16786609

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.24876264
2Nitrogen metabolism_Homo sapiens_hsa009104.73657908
3Mineral absorption_Homo sapiens_hsa049784.03377593
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.98522233
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.51008448
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.42971661
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.19007326
8Sulfur relay system_Homo sapiens_hsa041222.08048256
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06930132
10Fat digestion and absorption_Homo sapiens_hsa049751.97941213
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91972449
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.90852264
13Protein digestion and absorption_Homo sapiens_hsa049741.82896169
14Galactose metabolism_Homo sapiens_hsa000521.80712276
15Histidine metabolism_Homo sapiens_hsa003401.71564532
16Renin-angiotensin system_Homo sapiens_hsa046141.71331971
17Fructose and mannose metabolism_Homo sapiens_hsa000511.68594928
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.67602834
19Fatty acid degradation_Homo sapiens_hsa000711.61346445
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.52381117
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50149716
22Thyroid cancer_Homo sapiens_hsa052161.46919586
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46355064
24Adherens junction_Homo sapiens_hsa045201.45116938
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43957387
26Retinol metabolism_Homo sapiens_hsa008301.40562980
27ECM-receptor interaction_Homo sapiens_hsa045121.34741716
28Other glycan degradation_Homo sapiens_hsa005111.33710852
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.31469022
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25953737
31Bile secretion_Homo sapiens_hsa049761.25777465
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.21291643
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.21231174
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20562561
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19546883
36TNF signaling pathway_Homo sapiens_hsa046681.14352339
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13550685
38Linoleic acid metabolism_Homo sapiens_hsa005911.11951776
39Caffeine metabolism_Homo sapiens_hsa002321.11197394
40Toxoplasmosis_Homo sapiens_hsa051451.04846986
41Arachidonic acid metabolism_Homo sapiens_hsa005901.04787117
42Leishmaniasis_Homo sapiens_hsa051401.01350141
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00530928
44Small cell lung cancer_Homo sapiens_hsa052220.99996101
45Apoptosis_Homo sapiens_hsa042100.99303207
46Chronic myeloid leukemia_Homo sapiens_hsa052200.99249420
47Sphingolipid metabolism_Homo sapiens_hsa006000.95550272
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92668090
49Starch and sucrose metabolism_Homo sapiens_hsa005000.91729259
50Vitamin digestion and absorption_Homo sapiens_hsa049770.89654085
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89494788
52Tight junction_Homo sapiens_hsa045300.89132305
53Hepatitis C_Homo sapiens_hsa051600.88977155
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88916178
55Tryptophan metabolism_Homo sapiens_hsa003800.87095944
56Bladder cancer_Homo sapiens_hsa052190.84992866
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84519558
58Acute myeloid leukemia_Homo sapiens_hsa052210.84515873
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83974588
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83872664
61Arginine biosynthesis_Homo sapiens_hsa002200.82756849
62Influenza A_Homo sapiens_hsa051640.81421000
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.79267770
64Focal adhesion_Homo sapiens_hsa045100.77568150
65Legionellosis_Homo sapiens_hsa051340.77548778
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77131363
67Proteoglycans in cancer_Homo sapiens_hsa052050.77081325
68Endometrial cancer_Homo sapiens_hsa052130.75205932
69Osteoclast differentiation_Homo sapiens_hsa043800.74791605
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71396527
71Propanoate metabolism_Homo sapiens_hsa006400.71381343
72Chemical carcinogenesis_Homo sapiens_hsa052040.70282094
73Hematopoietic cell lineage_Homo sapiens_hsa046400.69784847
74Fatty acid metabolism_Homo sapiens_hsa012120.69571406
75p53 signaling pathway_Homo sapiens_hsa041150.68236765
76Pancreatic cancer_Homo sapiens_hsa052120.68185751
77Phototransduction_Homo sapiens_hsa047440.67374470
78Malaria_Homo sapiens_hsa051440.66619066
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65471934
80African trypanosomiasis_Homo sapiens_hsa051430.65378854
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62760539
82Arginine and proline metabolism_Homo sapiens_hsa003300.62702047
83Salmonella infection_Homo sapiens_hsa051320.62669115
84Renin secretion_Homo sapiens_hsa049240.61129677
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60422646
86T cell receptor signaling pathway_Homo sapiens_hsa046600.60420888
87Glycerolipid metabolism_Homo sapiens_hsa005610.60248612
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58682612
89PPAR signaling pathway_Homo sapiens_hsa033200.56758843
90MicroRNAs in cancer_Homo sapiens_hsa052060.56752967
91Hepatitis B_Homo sapiens_hsa051610.56571551
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56117557
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55753805
94Pertussis_Homo sapiens_hsa051330.55499969
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55306225
96Amoebiasis_Homo sapiens_hsa051460.53900591
97Insulin resistance_Homo sapiens_hsa049310.53096024
98ABC transporters_Homo sapiens_hsa020100.52699805
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51138119
100Herpes simplex infection_Homo sapiens_hsa051680.48913780
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.48661029
102Measles_Homo sapiens_hsa051620.47967356
103B cell receptor signaling pathway_Homo sapiens_hsa046620.47965892
104Choline metabolism in cancer_Homo sapiens_hsa052310.47963690
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47667730
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47490432
107Tyrosine metabolism_Homo sapiens_hsa003500.47337243
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46519597
109Fatty acid biosynthesis_Homo sapiens_hsa000610.45978149
110Hedgehog signaling pathway_Homo sapiens_hsa043400.45407673
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45135809
112Ovarian steroidogenesis_Homo sapiens_hsa049130.43991090
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.43971830
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43901008
115TGF-beta signaling pathway_Homo sapiens_hsa043500.43540508
116Inositol phosphate metabolism_Homo sapiens_hsa005620.43100751
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42564989
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.42518225
119Pyruvate metabolism_Homo sapiens_hsa006200.41944278
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.40760048
121Pathways in cancer_Homo sapiens_hsa052000.40460436
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40455331
123Pancreatic secretion_Homo sapiens_hsa049720.40134199
124Glutathione metabolism_Homo sapiens_hsa004800.39999269
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39973047
126Tuberculosis_Homo sapiens_hsa051520.39730602
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39726710
128Prostate cancer_Homo sapiens_hsa052150.39022809
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.37480904
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34438120
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32988507
132Vibrio cholerae infection_Homo sapiens_hsa051100.29632575
133Butanoate metabolism_Homo sapiens_hsa006500.28004057
134N-Glycan biosynthesis_Homo sapiens_hsa005100.26942583
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26610553
136Thyroid hormone synthesis_Homo sapiens_hsa049180.25746080
137Renal cell carcinoma_Homo sapiens_hsa052110.21998367
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20208691
139Prolactin signaling pathway_Homo sapiens_hsa049170.20000087
140FoxO signaling pathway_Homo sapiens_hsa040680.19148561
141Endocytosis_Homo sapiens_hsa041440.18668885
142GnRH signaling pathway_Homo sapiens_hsa049120.18441092

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