SLC25A5P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.97008445
2cullin deneddylation (GO:0010388)5.11265535
3protein deneddylation (GO:0000338)5.01976960
4chaperone-mediated protein transport (GO:0072321)4.83126062
5water-soluble vitamin biosynthetic process (GO:0042364)4.73164924
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.56706513
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.41289710
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.40792539
9regulation of cellular amino acid metabolic process (GO:0006521)4.40770411
10protein complex biogenesis (GO:0070271)4.36327404
11DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.27447364
12regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.25112491
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16319662
14ATP synthesis coupled proton transport (GO:0015986)4.16319662
15signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.15999251
16intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.15999251
17signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.15649628
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.15649628
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.15649628
20mitochondrial respiratory chain complex assembly (GO:0033108)4.12876997
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10079523
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.10079523
23NADH dehydrogenase complex assembly (GO:0010257)4.10079523
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.05044824
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.02091119
26negative regulation of ligase activity (GO:0051352)4.01422814
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.01422814
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.00177948
29rRNA modification (GO:0000154)3.98008608
30DNA deamination (GO:0045006)3.97663025
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.96001272
32signal transduction involved in DNA damage checkpoint (GO:0072422)3.96001272
33protein K6-linked ubiquitination (GO:0085020)3.92727754
34signal transduction involved in cell cycle checkpoint (GO:0072395)3.91210877
35protein neddylation (GO:0045116)3.68449340
36positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.67485088
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53944672
38positive regulation of ligase activity (GO:0051351)3.53322753
39GTP biosynthetic process (GO:0006183)3.51898874
40rRNA methylation (GO:0031167)3.50459465
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50317325
42cytokine biosynthetic process (GO:0042089)3.49958691
43respiratory chain complex IV assembly (GO:0008535)3.46378916
44respiratory electron transport chain (GO:0022904)3.45486728
45regulation of chronic inflammatory response (GO:0002676)3.44179293
46signal peptide processing (GO:0006465)3.42617062
47electron transport chain (GO:0022900)3.42136090
48DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.29636462
49cytochrome complex assembly (GO:0017004)3.28433482
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.28372083
51telomere maintenance via semi-conservative replication (GO:0032201)3.28303065
52positive regulation of cell cycle arrest (GO:0071158)3.21959002
53CENP-A containing nucleosome assembly (GO:0034080)3.20787818
54chromatin remodeling at centromere (GO:0031055)3.17821238
55regulation of cellular amine metabolic process (GO:0033238)3.09810107
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07427371
57establishment of integrated proviral latency (GO:0075713)3.05923873
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.04204299
59IMP biosynthetic process (GO:0006188)3.03448650
60postreplication repair (GO:0006301)3.01887867
61amino acid activation (GO:0043038)3.01047558
62tRNA aminoacylation (GO:0043039)3.01047558
63DNA strand elongation involved in DNA replication (GO:0006271)3.00114819
64intracellular protein transmembrane import (GO:0044743)2.97276412
65tRNA aminoacylation for protein translation (GO:0006418)2.96444998
66regulation of ligase activity (GO:0051340)2.95116744
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90118400
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90118400
69protein-cofactor linkage (GO:0018065)2.88350623
70UTP biosynthetic process (GO:0006228)2.87356885
71positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.84564621
72regulation of mitochondrial translation (GO:0070129)2.83647477
73guanosine-containing compound biosynthetic process (GO:1901070)2.82533474
74mitochondrial RNA metabolic process (GO:0000959)2.81813605
75replication fork processing (GO:0031297)2.81405357
76tRNA metabolic process (GO:0006399)2.80993748
77recombinational repair (GO:0000725)2.80588564
78protein targeting to mitochondrion (GO:0006626)2.80204426
79DNA strand elongation (GO:0022616)2.80131818
80purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78933052
81cytokine metabolic process (GO:0042107)2.78782662
82pseudouridine synthesis (GO:0001522)2.78614133
83righting reflex (GO:0060013)2.78493561
84histone exchange (GO:0043486)2.78351922
85double-strand break repair via homologous recombination (GO:0000724)2.77662893
86cell wall macromolecule catabolic process (GO:0016998)2.75189337
87telomere maintenance via telomere lengthening (GO:0010833)2.74295857
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74001023
89tRNA processing (GO:0008033)2.73060838
90antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.72170209
91negative regulation of protein ubiquitination (GO:0031397)2.72125488
92piRNA metabolic process (GO:0034587)2.69084425
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67275133
94signal transduction in response to DNA damage (GO:0042770)2.66450248
95inner mitochondrial membrane organization (GO:0007007)2.66102143
96nonmotile primary cilium assembly (GO:0035058)2.65209468
97protein K11-linked ubiquitination (GO:0070979)2.64782863
98regulation of cell cycle arrest (GO:0071156)2.64691865
99G1/S transition of mitotic cell cycle (GO:0000082)2.62379655
100cell cycle G1/S phase transition (GO:0044843)2.62379655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.18894498
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.55422492
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.03897195
4VDR_22108803_ChIP-Seq_LS180_Human3.89172223
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67049530
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29339295
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14124834
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.98544385
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.82806914
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81930203
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81586464
12E2F7_22180533_ChIP-Seq_HELA_Human2.64995702
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59534771
14VDR_23849224_ChIP-Seq_CD4+_Human2.58846375
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57439734
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38096802
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36831048
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34609643
19ELK1_19687146_ChIP-ChIP_HELA_Human2.29693185
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.28028593
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.16264369
22FOXP3_21729870_ChIP-Seq_TREG_Human2.12546685
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.02734373
24ZNF274_21170338_ChIP-Seq_K562_Hela2.02062212
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98409648
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88113374
27IGF1R_20145208_ChIP-Seq_DFB_Human1.87948348
28EWS_26573619_Chip-Seq_HEK293_Human1.77738858
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76526314
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72537278
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71705598
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71379166
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69116702
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67734971
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62980163
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61196754
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53909695
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52417491
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51888105
40MYC_18940864_ChIP-ChIP_HL60_Human1.50830404
41GBX2_23144817_ChIP-Seq_PC3_Human1.49701079
42GABP_19822575_ChIP-Seq_HepG2_Human1.46114351
43DCP1A_22483619_ChIP-Seq_HELA_Human1.45426247
44IRF1_19129219_ChIP-ChIP_H3396_Human1.44921410
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42469087
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41454034
47FUS_26573619_Chip-Seq_HEK293_Human1.41229506
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.36228757
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34065570
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33072281
51TTF2_22483619_ChIP-Seq_HELA_Human1.32607573
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.32030650
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30654552
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30381911
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29867561
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28879022
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24265789
58TP53_22573176_ChIP-Seq_HFKS_Human1.22850587
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.22180190
60P300_19829295_ChIP-Seq_ESCs_Human1.21224417
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16913672
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16063927
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15815362
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15793699
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14819484
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14290925
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12614020
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11447524
69ER_23166858_ChIP-Seq_MCF-7_Human1.11282194
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06167682
71NCOR_22424771_ChIP-Seq_293T_Human1.05823383
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05275571
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01874759
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.01874759
75NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99915708
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99468022
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99131714
78MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97989453
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97803872
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96996803
81AR_20517297_ChIP-Seq_VCAP_Human0.96770416
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95599606
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93582839
84NANOG_19829295_ChIP-Seq_ESCs_Human0.93556061
85SOX2_19829295_ChIP-Seq_ESCs_Human0.93556061
86TCF4_22108803_ChIP-Seq_LS180_Human0.92875866
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.91168780
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90738800
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88642592
90SALL4_22934838_ChIP-ChIP_CD34+_Human0.87455033
91BCAT_22108803_ChIP-Seq_LS180_Human0.86787513
92HOXB7_26014856_ChIP-Seq_BT474_Human0.86037773
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85099227
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.84919961
95XRN2_22483619_ChIP-Seq_HELA_Human0.84537354
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84064432
97HTT_18923047_ChIP-ChIP_STHdh_Human0.83797650
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83789639
99GATA3_26560356_Chip-Seq_TH2_Human0.82752954
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81695290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.81082304
2MP0002736_abnormal_nociception_after3.69601488
3MP0003806_abnormal_nucleotide_metabolis3.69516960
4MP0010094_abnormal_chromosome_stability2.95848962
5MP0003646_muscle_fatigue2.95774091
6MP0008057_abnormal_DNA_replication2.85059455
7MP0000372_irregular_coat_pigmentation2.82226041
8MP0001968_abnormal_touch/_nociception2.74992552
9MP0002837_dystrophic_cardiac_calcinosis2.50859835
10MP0003786_premature_aging2.49925646
11MP0006036_abnormal_mitochondrial_physio2.42267831
12MP0005408_hypopigmentation2.27096975
13MP0003693_abnormal_embryo_hatching2.12086490
14MP0008875_abnormal_xenobiotic_pharmacok2.06155388
15MP0003186_abnormal_redox_activity1.91767046
16MP0003718_maternal_effect1.87361054
17MP0002102_abnormal_ear_morphology1.86326511
18MP0006035_abnormal_mitochondrial_morpho1.83396196
19MP0003880_abnormal_central_pattern1.78829160
20MP0008872_abnormal_physiological_respon1.78180629
21MP0005075_abnormal_melanosome_morpholog1.77976934
22MP0001501_abnormal_sleep_pattern1.74453109
23MP0004142_abnormal_muscle_tone1.74105987
24MP0006072_abnormal_retinal_apoptosis1.73625780
25MP0003111_abnormal_nucleus_morphology1.67233323
26MP0001986_abnormal_taste_sensitivity1.62490992
27MP0005551_abnormal_eye_electrophysiolog1.59748677
28MP0003077_abnormal_cell_cycle1.57046556
29MP0004957_abnormal_blastocyst_morpholog1.55978032
30MP0000685_abnormal_immune_system1.47663005
31MP0004147_increased_porphyrin_level1.46094178
32MP0005171_absent_coat_pigmentation1.42194963
33MP0003136_yellow_coat_color1.40427188
34MP0001835_abnormal_antigen_presentation1.40346285
35MP0009046_muscle_twitch1.38688819
36MP0003195_calcinosis1.31282069
37MP0002095_abnormal_skin_pigmentation1.30517040
38MP0004885_abnormal_endolymph1.26945930
39MP0001529_abnormal_vocalization1.26500696
40MP0005253_abnormal_eye_physiology1.26056405
41MP0010386_abnormal_urinary_bladder1.25526434
42MP0005165_increased_susceptibility_to1.25302027
43MP0005671_abnormal_response_to1.25233625
44MP0002006_tumorigenesis1.23757595
45MP0001873_stomach_inflammation1.23499867
46MP0008877_abnormal_DNA_methylation1.20954081
47MP0002272_abnormal_nervous_system1.20091490
48MP0002938_white_spotting1.18546394
49MP0000358_abnormal_cell_content/1.17874979
50MP0001984_abnormal_olfaction1.10859320
51MP0001905_abnormal_dopamine_level1.10181665
52MP0008007_abnormal_cellular_replicative1.09677124
53MP0001764_abnormal_homeostasis1.08778901
54MP0008775_abnormal_heart_ventricle1.07866686
55MP0002733_abnormal_thermal_nociception1.07563252
56MP0009333_abnormal_splenocyte_physiolog1.07227541
57MP0000427_abnormal_hair_cycle1.05211836
58MP0004742_abnormal_vestibular_system1.04345153
59MP0004215_abnormal_myocardial_fiber1.03859678
60MP0001486_abnormal_startle_reflex1.03757901
61MP0008932_abnormal_embryonic_tissue1.02165821
62MP0002138_abnormal_hepatobiliary_system1.01060840
63MP0002148_abnormal_hypersensitivity_rea0.99192825
64MP0003119_abnormal_digestive_system0.98916751
65MP0005670_abnormal_white_adipose0.98309725
66MP0005646_abnormal_pituitary_gland0.97633185
67MP0004145_abnormal_muscle_electrophysio0.97133701
68MP0001970_abnormal_pain_threshold0.96377128
69MP0002210_abnormal_sex_determination0.96089054
70MP0009764_decreased_sensitivity_to0.96018583
71MP0005084_abnormal_gallbladder_morpholo0.92982381
72MP0005379_endocrine/exocrine_gland_phen0.92127241
73MP0001485_abnormal_pinna_reflex0.90054108
74MP0005410_abnormal_fertilization0.88130049
75MP0001929_abnormal_gametogenesis0.87680082
76MP0002751_abnormal_autonomic_nervous0.87624741
77MP0005423_abnormal_somatic_nervous0.83562974
78MP0009745_abnormal_behavioral_response0.83030111
79MP0005389_reproductive_system_phenotype0.81593929
80MP0004782_abnormal_surfactant_physiolog0.81139535
81MP0005645_abnormal_hypothalamus_physiol0.79516860
82MP0001756_abnormal_urination0.79325134
83MP0006276_abnormal_autonomic_nervous0.77252243
84MP0000653_abnormal_sex_gland0.76096377
85MP0005085_abnormal_gallbladder_physiolo0.75971934
86MP0005636_abnormal_mineral_homeostasis0.75171457
87MP0001963_abnormal_hearing_physiology0.74850173
88MP0002166_altered_tumor_susceptibility0.73949220
89MP0009785_altered_susceptibility_to0.73847873
90MP0005365_abnormal_bile_salt0.73631640
91MP0004019_abnormal_vitamin_homeostasis0.73525382
92MP0001145_abnormal_male_reproductive0.72839350
93MP0005266_abnormal_metabolism0.72309145
94MP0001853_heart_inflammation0.72295617
95MP0005174_abnormal_tail_pigmentation0.70310173
96MP0002067_abnormal_sensory_capabilities0.69797870
97MP0002160_abnormal_reproductive_system0.67496612
98MP0002090_abnormal_vision0.66517601
99MP0004043_abnormal_pH_regulation0.63166523
100MP0001119_abnormal_female_reproductive0.62784462

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.57764002
2Acute encephalopathy (HP:0006846)4.86498700
3Abnormal mitochondria in muscle tissue (HP:0008316)4.83039680
4Progressive macrocephaly (HP:0004481)4.70676517
5Mitochondrial inheritance (HP:0001427)4.67692885
6Increased CSF lactate (HP:0002490)4.57842363
7Hepatocellular necrosis (HP:0001404)4.03805156
8Cerebral edema (HP:0002181)3.66251899
9Abnormality of the labia minora (HP:0012880)3.64510339
10Hepatic necrosis (HP:0002605)3.62952631
11Congenital sensorineural hearing impairment (HP:0008527)3.43358861
12Increased hepatocellular lipid droplets (HP:0006565)3.31233553
13Increased serum lactate (HP:0002151)3.13460151
14Congenital, generalized hypertrichosis (HP:0004540)3.12891030
15Lipid accumulation in hepatocytes (HP:0006561)2.93940027
16Renal Fanconi syndrome (HP:0001994)2.84738258
17Lactic acidosis (HP:0003128)2.76004018
18Respiratory failure (HP:0002878)2.75106619
19Optic disc pallor (HP:0000543)2.69080477
20Pancreatic cysts (HP:0001737)2.67652847
21Leukodystrophy (HP:0002415)2.61574035
22Increased serum pyruvate (HP:0003542)2.61458239
23Exertional dyspnea (HP:0002875)2.60511257
24Meckel diverticulum (HP:0002245)2.58210196
25Abnormality of glycolysis (HP:0004366)2.56738296
26Abnormality of the anterior horn cell (HP:0006802)2.54860119
27Degeneration of anterior horn cells (HP:0002398)2.54860119
28Abolished electroretinogram (ERG) (HP:0000550)2.51164405
29Exercise intolerance (HP:0003546)2.50835002
30Abnormality of the ileum (HP:0001549)2.42865839
31Pancreatic fibrosis (HP:0100732)2.40252498
32Lethargy (HP:0001254)2.37214157
33Congenital stationary night blindness (HP:0007642)2.29439539
34Medial flaring of the eyebrow (HP:0010747)2.27580898
35CNS demyelination (HP:0007305)2.26639343
36Molar tooth sign on MRI (HP:0002419)2.26161099
37Abnormality of midbrain morphology (HP:0002418)2.26161099
38Abnormality of chromosome stability (HP:0003220)2.24072200
393-Methylglutaconic aciduria (HP:0003535)2.22697303
40Increased intramyocellular lipid droplets (HP:0012240)2.22521919
41Abnormality of the prostate (HP:0008775)2.21024379
42Prostate neoplasm (HP:0100787)2.20828550
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.19409751
44True hermaphroditism (HP:0010459)2.18784477
45Supernumerary spleens (HP:0009799)2.14870149
46Methylmalonic acidemia (HP:0002912)2.08257164
47Cutaneous melanoma (HP:0012056)2.05807271
48Opisthotonus (HP:0002179)2.04441135
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04049894
50Adrenal hypoplasia (HP:0000835)2.03902329
51Abnormality of the preputium (HP:0100587)2.03867485
52Type I transferrin isoform profile (HP:0003642)2.03687660
53Methylmalonic aciduria (HP:0012120)2.02974666
54Progressive microcephaly (HP:0000253)2.00285423
55Aplasia/hypoplasia of the uterus (HP:0008684)2.00049307
56Abnormality of alanine metabolism (HP:0010916)1.96530916
57Hyperalaninemia (HP:0003348)1.96530916
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96530916
59Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95797521
60Glycosuria (HP:0003076)1.93888716
61Abnormality of urine glucose concentration (HP:0011016)1.93888716
62Palpitations (HP:0001962)1.93493785
63Neoplasm of the adrenal gland (HP:0100631)1.93391859
64Hypoplasia of the fovea (HP:0007750)1.92306726
65Aplasia/Hypoplasia of the fovea (HP:0008060)1.92306726
66Pendular nystagmus (HP:0012043)1.87558722
67Delayed CNS myelination (HP:0002188)1.86765411
68Retinal dysplasia (HP:0007973)1.84309210
69Abnormality of methionine metabolism (HP:0010901)1.82799033
70IgG deficiency (HP:0004315)1.80914650
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80726200
72Clubbing of toes (HP:0100760)1.80155625
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.80048528
74Abnormal protein N-linked glycosylation (HP:0012347)1.79070856
75Abnormal protein glycosylation (HP:0012346)1.79070856
76Abnormal glycosylation (HP:0012345)1.79070856
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79070856
78Chromsome breakage (HP:0040012)1.78966486
79Colon cancer (HP:0003003)1.78787327
80Patchy hypopigmentation of hair (HP:0011365)1.78520840
81Blindness (HP:0000618)1.77552394
82Congenital primary aphakia (HP:0007707)1.75828808
83Absent/shortened dynein arms (HP:0200106)1.74127461
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.74127461
85Hypoproteinemia (HP:0003075)1.72984307
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71230164
87Short 1st metacarpal (HP:0010034)1.70485713
88Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70485713
89Sclerocornea (HP:0000647)1.70331046
90Abnormal spermatogenesis (HP:0008669)1.69861906
91Abnormality of renal resorption (HP:0011038)1.68803424
92Cerebral hypomyelination (HP:0006808)1.68495594
93Constricted visual fields (HP:0001133)1.67531072
94Gait imbalance (HP:0002141)1.67010903
95Increased muscle lipid content (HP:0009058)1.66524453
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.64483365
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.64483365
98Gaze-evoked nystagmus (HP:0000640)1.62939518
99Emotional lability (HP:0000712)1.62913209
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.62905547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.08939871
2EIF2AK13.60403112
3STK163.47291608
4FRK3.27232466
5EIF2AK32.96913088
6PDK22.87150756
7BMPR1B2.56421029
8TSSK62.55973000
9SRPK12.53851038
10TRIM282.29932592
11NUAK12.17742704
12NEK12.14282888
13BUB12.00063575
14MST41.97918447
15PBK1.93319012
16VRK11.89007236
17MAP3K121.85165803
18PLK31.81640251
19PLK41.73573221
20CCNB11.67307620
21TLK11.52635470
22ZAK1.52358410
23NME11.48499264
24CSNK1G31.45760176
25GRK11.43419987
26MKNK21.41085662
27PLK21.37342761
28EPHA41.32894625
29NME21.31070135
30CSNK1A1L1.27965349
31OXSR11.26949586
32TAOK31.24143160
33PHKG21.22044469
34PHKG11.22044469
35CSNK1G21.17498688
36DAPK11.17467327
37MKNK11.17073016
38TIE11.13714896
39CSNK1G11.13381930
40CDK191.07606175
41MAPK131.06328329
42STK391.04098906
43PLK11.02701815
44ADRBK21.02658937
45ACVR1B1.01939878
46WNK40.92555827
47CDC70.92457696
48EIF2AK20.87358708
49TTK0.86755269
50STK38L0.85656707
51MYLK0.78650840
52BCKDK0.76688265
53LIMK10.75359765
54ERBB30.71837551
55KDR0.71638293
56CAMK2D0.71290830
57LMTK20.69491618
58MAP4K20.68624204
59ATR0.65103068
60TEC0.65100423
61PAK30.62540775
62GRK50.60721973
63ALK0.60534872
64BCR0.59909352
65TNIK0.59010619
66NEK60.58067616
67WNK30.57612720
68ADRBK10.56583865
69PTK2B0.55925164
70TXK0.55361593
71WEE10.53080301
72INSRR0.52924336
73RPS6KB20.51530574
74MAPKAPK30.51314018
75ILK0.50706546
76TAF10.49250229
77AURKB0.48728296
78CAMKK20.47912911
79CAMK2A0.47030471
80PASK0.46692093
81CSNK2A10.43764303
82ERBB40.42845276
83PRKCI0.41934380
84PAK40.40947008
85CAMK2G0.39782386
86AURKA0.39651602
87TGFBR10.39536749
88PRKCE0.39020475
89IKBKB0.38976562
90STK100.37877791
91PINK10.36993260
92MAPKAPK50.36739783
93BMPR20.35363793
94DAPK30.34048146
95CSNK2A20.32853193
96ATM0.31483601
97CSNK1A10.31397379
98PKN10.30722896
99CHEK20.30635282
100CAMK2B0.28998142

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.48439719
2Oxidative phosphorylation_Homo sapiens_hsa001903.12252326
3Homologous recombination_Homo sapiens_hsa034402.77994775
4DNA replication_Homo sapiens_hsa030302.62698415
5Parkinsons disease_Homo sapiens_hsa050122.60756280
6Non-homologous end-joining_Homo sapiens_hsa034502.55957937
7Protein export_Homo sapiens_hsa030602.48947493
8Mismatch repair_Homo sapiens_hsa034302.40576960
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32187321
10Asthma_Homo sapiens_hsa053102.07771353
11RNA polymerase_Homo sapiens_hsa030202.06625864
12Fanconi anemia pathway_Homo sapiens_hsa034601.94707690
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87356059
14Huntingtons disease_Homo sapiens_hsa050161.81602143
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77916813
16Nucleotide excision repair_Homo sapiens_hsa034201.73665480
17Base excision repair_Homo sapiens_hsa034101.71716538
18Alzheimers disease_Homo sapiens_hsa050101.70077623
19Ribosome_Homo sapiens_hsa030101.67356281
20RNA degradation_Homo sapiens_hsa030181.50091075
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.48551208
22Allograft rejection_Homo sapiens_hsa053301.47944879
23Pyrimidine metabolism_Homo sapiens_hsa002401.46852343
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45717305
25Sulfur metabolism_Homo sapiens_hsa009201.40967461
26One carbon pool by folate_Homo sapiens_hsa006701.38253608
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35011831
28Propanoate metabolism_Homo sapiens_hsa006401.31054474
29Basal transcription factors_Homo sapiens_hsa030221.29734436
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29039770
31Spliceosome_Homo sapiens_hsa030401.27489724
32Autoimmune thyroid disease_Homo sapiens_hsa053201.27170575
33Fatty acid elongation_Homo sapiens_hsa000621.25666420
34Type I diabetes mellitus_Homo sapiens_hsa049401.25500088
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24464820
36Purine metabolism_Homo sapiens_hsa002301.18593908
37Pyruvate metabolism_Homo sapiens_hsa006201.16676753
38RNA transport_Homo sapiens_hsa030131.15201252
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15184650
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12950711
41Peroxisome_Homo sapiens_hsa041461.10646710
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.10380986
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09164093
44Folate biosynthesis_Homo sapiens_hsa007901.05236656
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03221788
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95968278
47Collecting duct acid secretion_Homo sapiens_hsa049660.92067974
48Glutathione metabolism_Homo sapiens_hsa004800.88769106
49Cardiac muscle contraction_Homo sapiens_hsa042600.84613989
50Phototransduction_Homo sapiens_hsa047440.82268754
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81661214
52Pentose phosphate pathway_Homo sapiens_hsa000300.80745410
53Graft-versus-host disease_Homo sapiens_hsa053320.80091948
54Carbon metabolism_Homo sapiens_hsa012000.77006832
55Rheumatoid arthritis_Homo sapiens_hsa053230.76289802
56Antigen processing and presentation_Homo sapiens_hsa046120.75612762
57Tryptophan metabolism_Homo sapiens_hsa003800.75174642
58Fatty acid biosynthesis_Homo sapiens_hsa000610.74947045
59Metabolic pathways_Homo sapiens_hsa011000.72759617
60Linoleic acid metabolism_Homo sapiens_hsa005910.72570778
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71194031
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70629234
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69721205
64Biosynthesis of amino acids_Homo sapiens_hsa012300.69115327
65Fatty acid degradation_Homo sapiens_hsa000710.69029447
66Caffeine metabolism_Homo sapiens_hsa002320.68061277
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.65209269
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62507035
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62478285
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61908713
71Fatty acid metabolism_Homo sapiens_hsa012120.61424324
72Nitrogen metabolism_Homo sapiens_hsa009100.61310600
73Regulation of autophagy_Homo sapiens_hsa041400.60844790
74Olfactory transduction_Homo sapiens_hsa047400.60554448
75Sulfur relay system_Homo sapiens_hsa041220.59522044
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55546720
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54752703
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53798936
79Butanoate metabolism_Homo sapiens_hsa006500.51263543
80Chemical carcinogenesis_Homo sapiens_hsa052040.50953441
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50244468
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50208373
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49868705
84beta-Alanine metabolism_Homo sapiens_hsa004100.47587618
85Vitamin B6 metabolism_Homo sapiens_hsa007500.46324598
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45908380
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42428151
88Selenocompound metabolism_Homo sapiens_hsa004500.41878566
89Glycerolipid metabolism_Homo sapiens_hsa005610.39316166
90Cell cycle_Homo sapiens_hsa041100.38772578
91Retinol metabolism_Homo sapiens_hsa008300.35829394
92Arginine and proline metabolism_Homo sapiens_hsa003300.35598137
93N-Glycan biosynthesis_Homo sapiens_hsa005100.34917448
94Steroid biosynthesis_Homo sapiens_hsa001000.34356558
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32880232
96Primary immunodeficiency_Homo sapiens_hsa053400.32611984
97Fat digestion and absorption_Homo sapiens_hsa049750.32073573
98p53 signaling pathway_Homo sapiens_hsa041150.30684964
99Arachidonic acid metabolism_Homo sapiens_hsa005900.30253007
100Mineral absorption_Homo sapiens_hsa049780.27851789

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