SLC25A5P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.01972269
2proteasome assembly (GO:0043248)5.57216929
3cullin deneddylation (GO:0010388)4.51701907
4plasma membrane fusion (GO:0045026)4.19664608
5protein deneddylation (GO:0000338)4.10754524
6organelle disassembly (GO:1903008)3.97987111
7melanin biosynthetic process (GO:0042438)3.95291803
8rRNA methylation (GO:0031167)3.84390005
9signal peptide processing (GO:0006465)3.76994359
10kynurenine metabolic process (GO:0070189)3.76768331
11tryptophan metabolic process (GO:0006568)3.71590102
12DNA deamination (GO:0045006)3.71039315
13rRNA modification (GO:0000154)3.67387599
14water-soluble vitamin biosynthetic process (GO:0042364)3.64702722
15secondary metabolite biosynthetic process (GO:0044550)3.64155951
16aldehyde catabolic process (GO:0046185)3.63405640
17positive regulation of receptor recycling (GO:0001921)3.61385850
18regulation of centriole replication (GO:0046599)3.60952062
19melanin metabolic process (GO:0006582)3.60357096
20indole-containing compound catabolic process (GO:0042436)3.51994271
21indolalkylamine catabolic process (GO:0046218)3.51994271
22tryptophan catabolic process (GO:0006569)3.51994271
23mitotic G2 DNA damage checkpoint (GO:0007095)3.51803544
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.48987890
25ribonucleoprotein complex disassembly (GO:0032988)3.42163699
26mitochondrial DNA replication (GO:0006264)3.37141421
27indolalkylamine metabolic process (GO:0006586)3.36087776
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35526873
29mitotic G2/M transition checkpoint (GO:0044818)3.33923564
30ribosome assembly (GO:0042255)3.30675478
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30667571
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27223748
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26505643
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26505643
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.25757689
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25751803
37lysine metabolic process (GO:0006553)3.25565588
38lysine catabolic process (GO:0006554)3.25565588
39regulation of cellular amino acid metabolic process (GO:0006521)3.23798736
40histone exchange (GO:0043486)3.21457939
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18819737
42ATP synthesis coupled proton transport (GO:0015986)3.18819737
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18265798
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18265798
45artery smooth muscle contraction (GO:0014824)3.17670892
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16820402
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16820402
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16820402
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12685603
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12595888
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12550544
52IMP biosynthetic process (GO:0006188)3.11576504
53nucleotide transmembrane transport (GO:1901679)3.07987563
54DNA replication checkpoint (GO:0000076)3.06095192
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.04566090
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04566090
57negative regulation of ligase activity (GO:0051352)3.01054565
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01054565
59CENP-A containing nucleosome assembly (GO:0034080)2.99889140
60signal transduction involved in DNA damage checkpoint (GO:0072422)2.97728262
61signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97728262
62regulation of DNA endoreduplication (GO:0032875)2.95812577
63pseudouridine synthesis (GO:0001522)2.94743735
64signal transduction involved in cell cycle checkpoint (GO:0072395)2.91428759
65dopamine transport (GO:0015872)2.90757278
66tRNA aminoacylation (GO:0043039)2.90009323
67amino acid activation (GO:0043038)2.90009323
68double-strand break repair via homologous recombination (GO:0000724)2.87433874
69recombinational repair (GO:0000725)2.86769717
70replication fork processing (GO:0031297)2.86503463
71nucleoside transmembrane transport (GO:1901642)2.86389445
72regulation of non-canonical Wnt signaling pathway (GO:2000050)2.86169741
73histamine secretion (GO:0001821)2.85318948
74IMP metabolic process (GO:0046040)2.83986401
75chromatin remodeling at centromere (GO:0031055)2.81837160
76DNA strand elongation involved in DNA replication (GO:0006271)2.81337639
77tRNA aminoacylation for protein translation (GO:0006418)2.80487157
78respiratory chain complex IV assembly (GO:0008535)2.79938353
79protein K6-linked ubiquitination (GO:0085020)2.78697412
80tonic smooth muscle contraction (GO:0014820)2.76106728
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74659853
82endosome to melanosome transport (GO:0035646)2.73285235
83endosome to pigment granule transport (GO:0043485)2.73285235
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71361565
85tRNA metabolic process (GO:0006399)2.70237891
86mitochondrial RNA metabolic process (GO:0000959)2.70154332
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66841371
88dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.66006798
89platelet dense granule organization (GO:0060155)2.63762407
90ketone body metabolic process (GO:1902224)2.63137471
91L-methionine salvage (GO:0071267)2.63017119
92L-methionine biosynthetic process (GO:0071265)2.63017119
93amino acid salvage (GO:0043102)2.63017119
94piRNA metabolic process (GO:0034587)2.62541061
95rRNA catabolic process (GO:0016075)2.62339119
96regulation of centrosome cycle (GO:0046605)2.61925356
97DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.61524344
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60731286
99spindle assembly involved in mitosis (GO:0090307)2.60584601
100melanosome organization (GO:0032438)2.60449736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97094571
2E2F7_22180533_ChIP-Seq_HELA_Human4.14174175
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.70179379
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67021422
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.48551538
6VDR_22108803_ChIP-Seq_LS180_Human2.98329831
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92878216
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87579723
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82588682
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72274890
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.62078480
12ELK1_19687146_ChIP-ChIP_HELA_Human2.49035478
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43409609
14VDR_23849224_ChIP-Seq_CD4+_Human2.38462350
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.31807048
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29085770
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.26417550
18ZNF274_21170338_ChIP-Seq_K562_Hela2.23333626
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16820091
20EWS_26573619_Chip-Seq_HEK293_Human2.15098408
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.04987008
22FOXP3_21729870_ChIP-Seq_TREG_Human1.97444826
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84162561
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.83648098
25IGF1R_20145208_ChIP-Seq_DFB_Human1.74046556
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71689953
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68981525
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68918146
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66368001
30DCP1A_22483619_ChIP-Seq_HELA_Human1.65861597
31GBX2_23144817_ChIP-Seq_PC3_Human1.57299915
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56968734
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55946287
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54897185
35ER_23166858_ChIP-Seq_MCF-7_Human1.53342624
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50071512
37GABP_19822575_ChIP-Seq_HepG2_Human1.45390385
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38656672
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35644172
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35644024
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31701853
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29709925
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28000907
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.27350464
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26609633
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26337824
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26332381
48BCAT_22108803_ChIP-Seq_LS180_Human1.25849477
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25309473
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.25228340
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22858243
52FUS_26573619_Chip-Seq_HEK293_Human1.21212071
53AR_20517297_ChIP-Seq_VCAP_Human1.21071445
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18821122
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18097228
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.18097228
57CBP_20019798_ChIP-Seq_JUKART_Human1.17959019
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17959019
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17490505
60CDX2_22108803_ChIP-Seq_LS180_Human1.17244379
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.16936298
62SOX2_19829295_ChIP-Seq_ESCs_Human1.15332911
63NANOG_19829295_ChIP-Seq_ESCs_Human1.15332911
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13059911
65IRF1_19129219_ChIP-ChIP_H3396_Human1.12940717
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.12900601
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12544133
68MYC_18940864_ChIP-ChIP_HL60_Human1.11723903
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11221281
70SALL4_22934838_ChIP-ChIP_CD34+_Human1.09627026
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09203595
72P300_19829295_ChIP-Seq_ESCs_Human1.08424985
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05230697
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.03387071
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.03004656
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01568515
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01310068
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01028877
79HOXB7_26014856_ChIP-Seq_BT474_Human1.00706829
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99524399
81CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97658440
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95858997
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94563535
84TFEB_21752829_ChIP-Seq_HELA_Human0.94444686
85NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93325521
86TCF4_22108803_ChIP-Seq_LS180_Human0.92679574
87MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91395986
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91209218
89RBPJ_21746931_ChIP-Seq_IB4_Human0.91141396
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91110394
91AR_21909140_ChIP-Seq_LNCAP_Human0.91004795
92TP53_22573176_ChIP-Seq_HFKS_Human0.89908594
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.89298061
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88951174
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88656914
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88406888
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88248763
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87166846
99TAF15_26573619_Chip-Seq_HEK293_Human0.85965735
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85205450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.22312616
2MP0000372_irregular_coat_pigmentation4.95740570
3MP0005075_abnormal_melanosome_morpholog4.18595426
4MP0003646_muscle_fatigue3.78813829
5MP0002102_abnormal_ear_morphology3.76000418
6MP0005171_absent_coat_pigmentation3.59610440
7MP0003195_calcinosis3.19441899
8MP0005408_hypopigmentation2.83090643
9MP0008057_abnormal_DNA_replication2.81940031
10MP0003950_abnormal_plasma_membrane2.71296132
11MP0010094_abnormal_chromosome_stability2.68479121
12MP0008058_abnormal_DNA_repair2.58512614
13MP0004885_abnormal_endolymph2.41838153
14MP0006292_abnormal_olfactory_placode2.24728080
15MP0003693_abnormal_embryo_hatching2.21571858
16MP0004381_abnormal_hair_follicle2.19651455
17MP0005174_abnormal_tail_pigmentation2.16665358
18MP0006036_abnormal_mitochondrial_physio2.09223724
19MP0000015_abnormal_ear_pigmentation2.00746080
20MP0002095_abnormal_skin_pigmentation1.86577187
21MP0003136_yellow_coat_color1.83194123
22MP0004957_abnormal_blastocyst_morpholog1.82303986
23MP0009046_muscle_twitch1.79198952
24MP0008872_abnormal_physiological_respon1.78706320
25MP0002938_white_spotting1.78320359
26MP0000371_diluted_coat_color1.73430146
27MP0010234_abnormal_vibrissa_follicle1.68075546
28MP0003786_premature_aging1.66090506
29MP0002006_tumorigenesis1.63364355
30MP0002090_abnormal_vision1.58922894
31MP0002138_abnormal_hepatobiliary_system1.56298897
32MP0003718_maternal_effect1.47324409
33MP0008875_abnormal_xenobiotic_pharmacok1.41777762
34MP0002837_dystrophic_cardiac_calcinosis1.41316112
35MP0003077_abnormal_cell_cycle1.41286376
36MP0003111_abnormal_nucleus_morphology1.40790644
37MP0006035_abnormal_mitochondrial_morpho1.39963267
38MP0001324_abnormal_eye_pigmentation1.37938703
39MP0006072_abnormal_retinal_apoptosis1.34746331
40MP0000569_abnormal_digit_pigmentation1.30652861
41MP0003252_abnormal_bile_duct1.30647458
42MP0005084_abnormal_gallbladder_morpholo1.28560404
43MP0003878_abnormal_ear_physiology1.28181213
44MP0005377_hearing/vestibular/ear_phenot1.28181213
45MP0008877_abnormal_DNA_methylation1.24585200
46MP0010386_abnormal_urinary_bladder1.21216289
47MP0006054_spinal_hemorrhage1.18271984
48MP0005266_abnormal_metabolism1.17496555
49MP0009697_abnormal_copulation1.16684455
50MP0008007_abnormal_cellular_replicative1.12902081
51MP0002277_abnormal_respiratory_mucosa1.11220332
52MP0005551_abnormal_eye_electrophysiolog1.05392949
53MP0001501_abnormal_sleep_pattern1.05236577
54MP0001984_abnormal_olfaction1.04819677
55MP0004147_increased_porphyrin_level1.04187819
56MP0005253_abnormal_eye_physiology0.99015121
57MP0002075_abnormal_coat/hair_pigmentati0.98245429
58MP0005379_endocrine/exocrine_gland_phen0.92602876
59MP0006276_abnormal_autonomic_nervous0.86578915
60MP0001929_abnormal_gametogenesis0.85626990
61MP0010678_abnormal_skin_adnexa0.83157688
62MP0001881_abnormal_mammary_gland0.82052438
63MP0002928_abnormal_bile_duct0.79982469
64MP0002166_altered_tumor_susceptibility0.77430142
65MP0001186_pigmentation_phenotype0.76725746
66MP0001919_abnormal_reproductive_system0.75909881
67MP0009765_abnormal_xenobiotic_induced0.73601239
68MP0002229_neurodegeneration0.69820082
69MP0005389_reproductive_system_phenotype0.69322304
70MP0001764_abnormal_homeostasis0.68514330
71MP0002210_abnormal_sex_determination0.68139848
72MP0000647_abnormal_sebaceous_gland0.65150493
73MP0004043_abnormal_pH_regulation0.64755000
74MP0001661_extended_life_span0.63950213
75MP0002272_abnormal_nervous_system0.61582259
76MP0003186_abnormal_redox_activity0.60190642
77MP0003936_abnormal_reproductive_system0.59740195
78MP0005646_abnormal_pituitary_gland0.59533059
79MP0008995_early_reproductive_senescence0.59405018
80MP0003698_abnormal_male_reproductive0.59397659
81MP0004215_abnormal_myocardial_fiber0.59269234
82MP0000631_abnormal_neuroendocrine_gland0.58967148
83MP0000358_abnormal_cell_content/0.58829924
84MP0003283_abnormal_digestive_organ0.55515052
85MP0001293_anophthalmia0.55327561
86MP0000383_abnormal_hair_follicle0.55191808
87MP0002139_abnormal_hepatobiliary_system0.54931122
88MP0008775_abnormal_heart_ventricle0.54760813
89MP0003172_abnormal_lysosome_physiology0.54433964
90MP0001756_abnormal_urination0.53091285
91MP0009745_abnormal_behavioral_response0.52401050
92MP0009764_decreased_sensitivity_to0.52332260
93MP0001529_abnormal_vocalization0.52242645
94MP0002163_abnormal_gland_morphology0.51876515
95MP0000427_abnormal_hair_cycle0.51550382
96MP0005332_abnormal_amino_acid0.51043720
97MP0002160_abnormal_reproductive_system0.50876190
98MP0005636_abnormal_mineral_homeostasis0.49846429
99MP0000653_abnormal_sex_gland0.48753831
100MP0001666_abnormal_nutrient_absorption0.48517160

Predicted human phenotypes

RankGene SetZ-score
1Median cleft lip (HP:0000161)3.64418186
2Pancreatic cysts (HP:0001737)3.39646502
3Abnormality of the labia minora (HP:0012880)3.33862375
4Adrenal hypoplasia (HP:0000835)3.32493254
5Pancreatic fibrosis (HP:0100732)3.19018847
6Large for gestational age (HP:0001520)3.12426652
7Acute necrotizing encephalopathy (HP:0006965)3.12348334
8Type I transferrin isoform profile (HP:0003642)3.09505807
9Increased CSF lactate (HP:0002490)3.06648054
10Medial flaring of the eyebrow (HP:0010747)2.96839339
11Hepatic necrosis (HP:0002605)2.87795622
12Mitochondrial inheritance (HP:0001427)2.87667918
13Congenital stationary night blindness (HP:0007642)2.85958194
14Acute encephalopathy (HP:0006846)2.84211992
15Abnormal mitochondria in muscle tissue (HP:0008316)2.82997775
16Aplasia/Hypoplasia of the fovea (HP:0008060)2.79274313
17Hypoplasia of the fovea (HP:0007750)2.79274313
18Gonadal dysgenesis (HP:0000133)2.73721310
19Hepatocellular necrosis (HP:0001404)2.72380481
20Progressive macrocephaly (HP:0004481)2.69628514
21Opisthotonus (HP:0002179)2.69211904
22Abnormal sex determination (HP:0012244)2.55306362
23Sex reversal (HP:0012245)2.55306362
24Molar tooth sign on MRI (HP:0002419)2.55011408
25Abnormality of midbrain morphology (HP:0002418)2.55011408
26Patchy hypopigmentation of hair (HP:0011365)2.49266945
27Cerebral edema (HP:0002181)2.48845993
28Gaze-evoked nystagmus (HP:0000640)2.47240518
29Ependymoma (HP:0002888)2.42509928
30Abnormality of the renal cortex (HP:0011035)2.41962735
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.40317403
32Tubulointerstitial nephritis (HP:0001970)2.40007837
33Clubbing of toes (HP:0100760)2.39607152
34Abnormality of chromosome stability (HP:0003220)2.37085919
35Renal cortical cysts (HP:0000803)2.36666703
36Mesomelia (HP:0003027)2.34933682
37Congenital primary aphakia (HP:0007707)2.33595060
38Abnormality of methionine metabolism (HP:0010901)2.33441148
39Ocular albinism (HP:0001107)2.32632383
40Increased serum lactate (HP:0002151)2.32350554
41True hermaphroditism (HP:0010459)2.31691512
42Aplasia cutis congenita (HP:0001057)2.30947746
43Chromsome breakage (HP:0040012)2.30815741
44Aplasia/Hypoplasia of the macula (HP:0008059)2.28966118
45Congenital hepatic fibrosis (HP:0002612)2.28327099
46Congenital, generalized hypertrichosis (HP:0004540)2.27599492
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25742718
48Abnormal protein glycosylation (HP:0012346)2.25705330
49Abnormal glycosylation (HP:0012345)2.25705330
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25705330
51Abnormal protein N-linked glycosylation (HP:0012347)2.25705330
52Male pseudohermaphroditism (HP:0000037)2.24265773
53Gait imbalance (HP:0002141)2.23356368
54Meckel diverticulum (HP:0002245)2.21935351
55Abnormality of the pons (HP:0007361)2.20344719
56Abnormality of the fovea (HP:0000493)2.19483798
57Abnormality of the ileum (HP:0001549)2.18916295
58Large eyes (HP:0001090)2.17520904
59Nephrogenic diabetes insipidus (HP:0009806)2.17423803
60Hypoplasia of the pons (HP:0012110)2.16464938
61Abnormality of lateral ventricle (HP:0030047)2.15774078
62Methylmalonic acidemia (HP:0002912)2.15102823
63Duplicated collecting system (HP:0000081)2.14379098
64Abnormality of the preputium (HP:0100587)2.13776409
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.13633031
66Abnormality of the renal collecting system (HP:0004742)2.11500094
67Aplasia/Hypoplasia affecting the retina (HP:0008061)2.11180515
68Iris hypopigmentation (HP:0007730)2.11108296
69Abnormality of glycolysis (HP:0004366)2.08084287
70Nephronophthisis (HP:0000090)2.07868633
71Female pseudohermaphroditism (HP:0010458)2.06276267
72Cystic liver disease (HP:0006706)2.03820639
73Lipid accumulation in hepatocytes (HP:0006561)2.03257769
74Astigmatism (HP:0000483)1.99717591
75Renal Fanconi syndrome (HP:0001994)1.99647423
76Increased hepatocellular lipid droplets (HP:0006565)1.99546778
773-Methylglutaconic aciduria (HP:0003535)1.99538539
78Small intestinal stenosis (HP:0012848)1.99152052
79Duodenal stenosis (HP:0100867)1.99152052
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96557063
81Hypoglycemic coma (HP:0001325)1.95062445
82Facial cleft (HP:0002006)1.93006198
83Limb hypertonia (HP:0002509)1.92343586
84Neoplasm of the adrenal cortex (HP:0100641)1.90190842
85Absent/shortened dynein arms (HP:0200106)1.88463013
86Dynein arm defect of respiratory motile cilia (HP:0012255)1.88463013
87Genital tract atresia (HP:0001827)1.87398663
88Abnormality of the renal medulla (HP:0100957)1.86399435
89Birth length less than 3rd percentile (HP:0003561)1.85621129
90Ovarian neoplasm (HP:0100615)1.84574624
91Nausea (HP:0002018)1.83692959
92Neoplasm of the adrenal gland (HP:0100631)1.82436644
93Oligohydramnios (HP:0001562)1.81969790
94Methylmalonic aciduria (HP:0012120)1.81441891
95Testicular neoplasm (HP:0010788)1.78695212
96Abolished electroretinogram (ERG) (HP:0000550)1.78255888
97Abnormality of renal resorption (HP:0011038)1.78201620
98Postaxial hand polydactyly (HP:0001162)1.77655716
99Lethargy (HP:0001254)1.76010880
100Asplenia (HP:0001746)1.75571778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.15575337
2FRK3.74755637
3MST43.53337098
4EIF2AK33.15180172
5WEE13.09294711
6ACVR1B2.95154752
7FER2.85275093
8FES2.80530588
9TSSK62.75107128
10STK162.44861234
11NUAK12.43102704
12PNCK2.34903713
13BUB12.11475273
14EIF2AK12.08326243
15PDK22.02493670
16PLK31.78649944
17TRIM281.69086708
18PBK1.67308066
19ALK1.61418092
20BMPR1B1.60668108
21GRK11.54665771
22PLK21.51985772
23NEK11.40066249
24VRK21.36253403
25CCNB11.35991863
26WNK31.26625189
27TAF11.25095440
28PINK11.23243112
29ADRBK21.18366895
30TEC1.11154676
31DAPK11.11022229
32SRPK11.10401391
33EIF2AK21.05844965
34GRK50.97056860
35OXSR10.93360704
36MAP3K120.92654589
37PLK10.91320744
38PLK40.90057962
39MAPK130.89036829
40TTK0.87144807
41MYLK0.85434147
42MKNK20.84443399
43PTK2B0.81265768
44ERBB30.79482143
45CDC70.76406259
46ATR0.72477836
47CHEK20.71207079
48TNIK0.71134828
49STK30.68977864
50ZAK0.66439927
51FLT30.65024171
52NEK20.64128912
53TGFBR10.64022874
54STK390.63372846
55VRK10.62876406
56PRKCE0.60955729
57SIK30.60319625
58AKT30.58394043
59NME10.57546829
60CSNK1A10.53289784
61ATM0.51572295
62MKNK10.50293057
63MAP4K20.47109105
64GRK60.46568408
65CSNK1E0.45051810
66INSRR0.43196452
67PRKCG0.41008846
68PHKG10.39531004
69PHKG20.39531004
70STK40.39285571
71FGR0.39208620
72TNK20.39152533
73TIE10.38968308
74FGFR10.38344883
75PAK60.36908233
76ADRBK10.36564059
77KIT0.35703069
78BMPR20.35479834
79FGFR20.35331762
80TXK0.34851606
81CSNK2A10.34838834
82PAK30.33088841
83ERBB40.31504658
84IKBKB0.31132038
85CSNK1G10.30955142
86CAMK2A0.30789534
87CHEK10.29996901
88TGFBR20.29565706
89CDK30.29303159
90STK38L0.28846664
91MAPK110.28586835
92CAMK10.27414153
93CSNK1D0.26255778
94CSNK1G30.25981958
95AURKB0.24512497
96BCKDK0.24441320
97DAPK30.24116059
98PRKCA0.24020844
99MAPKAPK50.23087999
100IRAK10.22925673

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.53179277
2Homologous recombination_Homo sapiens_hsa034402.83348471
3Protein export_Homo sapiens_hsa030602.78193298
4Non-homologous end-joining_Homo sapiens_hsa034502.67200784
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62606868
6Parkinsons disease_Homo sapiens_hsa050122.53135096
7DNA replication_Homo sapiens_hsa030302.51521496
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46533539
9Mismatch repair_Homo sapiens_hsa034302.37894249
10Oxidative phosphorylation_Homo sapiens_hsa001902.34003980
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25279018
12One carbon pool by folate_Homo sapiens_hsa006702.13477445
13Tryptophan metabolism_Homo sapiens_hsa003801.95879575
14Sulfur metabolism_Homo sapiens_hsa009201.89645400
15Base excision repair_Homo sapiens_hsa034101.88069708
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.84341404
17RNA transport_Homo sapiens_hsa030131.71882338
18Propanoate metabolism_Homo sapiens_hsa006401.66372571
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64980462
20Glutathione metabolism_Homo sapiens_hsa004801.62486027
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.59703156
22RNA degradation_Homo sapiens_hsa030181.57850350
23Sulfur relay system_Homo sapiens_hsa041221.50746111
24Fanconi anemia pathway_Homo sapiens_hsa034601.45625694
25Basal transcription factors_Homo sapiens_hsa030221.44056729
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41167255
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39643946
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35929373
29RNA polymerase_Homo sapiens_hsa030201.31994507
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31645223
31Nucleotide excision repair_Homo sapiens_hsa034201.29910617
32Huntingtons disease_Homo sapiens_hsa050161.29054461
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27974684
34N-Glycan biosynthesis_Homo sapiens_hsa005101.22462981
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20966953
36Alzheimers disease_Homo sapiens_hsa050101.20325033
37Folate biosynthesis_Homo sapiens_hsa007901.19071912
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19013269
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18445748
40Phototransduction_Homo sapiens_hsa047441.14755769
41Purine metabolism_Homo sapiens_hsa002301.14482982
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13740562
43Glycerolipid metabolism_Homo sapiens_hsa005611.10396994
44Chemical carcinogenesis_Homo sapiens_hsa052041.10343106
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.98260156
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97394629
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96514173
48Pyrimidine metabolism_Homo sapiens_hsa002400.95744765
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.94752201
50Pyruvate metabolism_Homo sapiens_hsa006200.93840314
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93835911
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90985979
53Pentose phosphate pathway_Homo sapiens_hsa000300.90159566
54Caffeine metabolism_Homo sapiens_hsa002320.89300636
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88114436
56Retinol metabolism_Homo sapiens_hsa008300.87232518
57Fatty acid degradation_Homo sapiens_hsa000710.86941441
58p53 signaling pathway_Homo sapiens_hsa041150.86792267
59Fructose and mannose metabolism_Homo sapiens_hsa000510.85973820
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85023714
61Cell cycle_Homo sapiens_hsa041100.84488402
62Peroxisome_Homo sapiens_hsa041460.82339465
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81314758
64Butanoate metabolism_Homo sapiens_hsa006500.80956596
65Tyrosine metabolism_Homo sapiens_hsa003500.80875930
66Olfactory transduction_Homo sapiens_hsa047400.79555501
67Metabolic pathways_Homo sapiens_hsa011000.78673655
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78635703
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.78216242
70Selenocompound metabolism_Homo sapiens_hsa004500.76044324
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75159573
72Biosynthesis of amino acids_Homo sapiens_hsa012300.72847153
73Lysine degradation_Homo sapiens_hsa003100.69656907
74Fatty acid elongation_Homo sapiens_hsa000620.69136341
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68955255
76beta-Alanine metabolism_Homo sapiens_hsa004100.67020383
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66951765
78Nitrogen metabolism_Homo sapiens_hsa009100.63100535
79Starch and sucrose metabolism_Homo sapiens_hsa005000.60884183
80Oocyte meiosis_Homo sapiens_hsa041140.57374883
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55822111
82Linoleic acid metabolism_Homo sapiens_hsa005910.53851858
83Carbon metabolism_Homo sapiens_hsa012000.53116255
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.49429280
85Regulation of autophagy_Homo sapiens_hsa041400.46556725
86Fat digestion and absorption_Homo sapiens_hsa049750.44396272
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43489436
88Histidine metabolism_Homo sapiens_hsa003400.42803062
89Pancreatic secretion_Homo sapiens_hsa049720.42615312
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42377953
91Primary immunodeficiency_Homo sapiens_hsa053400.39920596
92Steroid biosynthesis_Homo sapiens_hsa001000.39380247
93Spliceosome_Homo sapiens_hsa030400.39098472
94Arginine and proline metabolism_Homo sapiens_hsa003300.35881993
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35834363
96Collecting duct acid secretion_Homo sapiens_hsa049660.34724209
97Ether lipid metabolism_Homo sapiens_hsa005650.34262796
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32950647
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30099859
100Sphingolipid metabolism_Homo sapiens_hsa006000.27488671

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