SLC25A5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.63261124
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.35625882
3ATP synthesis coupled proton transport (GO:0015986)5.35625882
4proteasome assembly (GO:0043248)4.75761832
5DNA double-strand break processing (GO:0000729)4.74965059
6water-soluble vitamin biosynthetic process (GO:0042364)4.65586372
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.56386017
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.43892268
9protein complex biogenesis (GO:0070271)4.39141182
10regulation of cellular amino acid metabolic process (GO:0006521)4.32980547
11DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.29965505
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.26938495
13signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.25918838
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.25918838
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.25918838
16DNA catabolic process, exonucleolytic (GO:0000738)4.24462086
17respiratory electron transport chain (GO:0022904)4.23607620
18DNA deamination (GO:0045006)4.22443703
19electron transport chain (GO:0022900)4.19768656
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.19411147
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.19411147
22NADH dehydrogenase complex assembly (GO:0010257)4.15446515
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15446515
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.15446515
25negative regulation of ligase activity (GO:0051352)4.12483290
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.12483290
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.12409484
28signal transduction involved in DNA damage checkpoint (GO:0072422)4.07664140
29signal transduction involved in DNA integrity checkpoint (GO:0072401)4.07664140
30mitochondrial respiratory chain complex assembly (GO:0033108)4.06377380
31signal transduction involved in cell cycle checkpoint (GO:0072395)4.02478442
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.93934323
33rRNA modification (GO:0000154)3.87240682
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82907513
35protein neddylation (GO:0045116)3.73191689
36negative regulation of thymocyte apoptotic process (GO:0070244)3.68778609
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65458939
38positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.65216488
39protein deneddylation (GO:0000338)3.62233479
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61753670
41oxidative phosphorylation (GO:0006119)3.59362612
42cullin deneddylation (GO:0010388)3.54725543
43rRNA catabolic process (GO:0016075)3.47165690
44positive regulation of ligase activity (GO:0051351)3.45302937
45ribosome assembly (GO:0042255)3.36779483
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.36389701
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36389701
48rRNA methylation (GO:0031167)3.32194858
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28525476
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28525476
51positive regulation of cell cycle arrest (GO:0071158)3.28087331
52ribosomal large subunit biogenesis (GO:0042273)3.27048336
53cytochrome complex assembly (GO:0017004)3.23486389
54respiratory chain complex IV assembly (GO:0008535)3.21290166
55DNA damage response, detection of DNA damage (GO:0042769)3.18885171
56DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.17403795
57regulation of thymocyte apoptotic process (GO:0070243)3.16853247
58chaperone-mediated protein transport (GO:0072321)3.16304964
59hydrogen ion transmembrane transport (GO:1902600)3.13156207
60regulation of ubiquitin-protein transferase activity (GO:0051438)3.12322279
61maturation of 5.8S rRNA (GO:0000460)3.11660881
62regulation of cellular amine metabolic process (GO:0033238)3.11128303
63protein-cofactor linkage (GO:0018065)3.08040196
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06230437
65IMP biosynthetic process (GO:0006188)3.04711601
66iron-sulfur cluster assembly (GO:0016226)3.01479852
67metallo-sulfur cluster assembly (GO:0031163)3.01479852
68organelle disassembly (GO:1903008)3.00582902
69ATP biosynthetic process (GO:0006754)2.99350721
70regulation of ligase activity (GO:0051340)2.97858147
71platelet dense granule organization (GO:0060155)2.97806983
72aldehyde catabolic process (GO:0046185)2.96872553
73negative regulation of protein ubiquitination (GO:0031397)2.94830998
74AMP metabolic process (GO:0046033)2.89849256
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.88558034
76purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86981345
77kynurenine metabolic process (GO:0070189)2.86805061
78RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86324162
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85525115
80hydrogen transport (GO:0006818)2.84611007
81regulation of mitotic spindle checkpoint (GO:1903504)2.83902149
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83902149
83proton transport (GO:0015992)2.83278398
84mismatch repair (GO:0006298)2.82875725
85protein localization to cilium (GO:0061512)2.82795175
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81947690
87negative regulation of cell cycle G1/S phase transition (GO:1902807)2.78550919
88negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.78550919
89behavioral response to nicotine (GO:0035095)2.78534675
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.77652822
91replication fork processing (GO:0031297)2.77466210
92peptidyl-histidine modification (GO:0018202)2.76568608
93negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.76566383
94purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.75524506
95purine nucleoside monophosphate biosynthetic process (GO:0009127)2.75524506
96DNA replication checkpoint (GO:0000076)2.74553399
97chromatin remodeling at centromere (GO:0031055)2.74192180
98synapsis (GO:0007129)2.74093918
99postreplication repair (GO:0006301)2.73627521
100CENP-A containing nucleosome assembly (GO:0034080)2.71575856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.37348720
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.54592389
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.24352886
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63564996
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40278329
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09360280
7VDR_22108803_ChIP-Seq_LS180_Human2.98027934
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.96898485
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.69512471
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64645981
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.63657757
12VDR_23849224_ChIP-Seq_CD4+_Human2.61658851
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52838181
14ZNF274_21170338_ChIP-Seq_K562_Hela2.46002329
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43422511
16ELK1_19687146_ChIP-ChIP_HELA_Human2.31877626
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30693986
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.18352797
19FOXP3_21729870_ChIP-Seq_TREG_Human2.17403245
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.12084757
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07902153
22E2F7_22180533_ChIP-Seq_HELA_Human2.02300199
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94919343
24IGF1R_20145208_ChIP-Seq_DFB_Human1.93790517
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92122112
26MYC_18940864_ChIP-ChIP_HL60_Human1.91002959
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89541637
28IRF1_19129219_ChIP-ChIP_H3396_Human1.86059989
29EWS_26573619_Chip-Seq_HEK293_Human1.78207432
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74069207
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65706787
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64001478
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59674983
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57192809
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54217951
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53895148
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.47600411
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46617086
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45610300
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43438454
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41396412
42GABP_19822575_ChIP-Seq_HepG2_Human1.40455851
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40006606
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37294056
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35469932
46DCP1A_22483619_ChIP-Seq_HELA_Human1.34552722
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33244073
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31284741
49TTF2_22483619_ChIP-Seq_HELA_Human1.31141576
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30400158
51FUS_26573619_Chip-Seq_HEK293_Human1.29378792
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28547743
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.28106672
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26824739
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24298602
56TAF15_26573619_Chip-Seq_HEK293_Human1.24173013
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22949769
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22732477
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18474919
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.17092258
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16859445
62NCOR_22424771_ChIP-Seq_293T_Human1.16748606
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15939545
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14496284
65TP53_22573176_ChIP-Seq_HFKS_Human1.10978883
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10674059
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09484724
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08760983
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08303840
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08291450
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07819786
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07734122
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07520781
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05997170
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05798382
76XRN2_22483619_ChIP-Seq_HELA_Human1.05122413
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04357317
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02070419
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.01957732
80AR_21572438_ChIP-Seq_LNCaP_Human1.01238221
81AR_20517297_ChIP-Seq_VCAP_Human1.01181269
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.00854354
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.00502123
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00502123
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00416763
86NANOG_19829295_ChIP-Seq_ESCs_Human1.00413036
87SOX2_19829295_ChIP-Seq_ESCs_Human1.00413036
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.99624947
89P300_19829295_ChIP-Seq_ESCs_Human0.97672255
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96609672
91LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95919035
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93025083
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91520856
94ER_23166858_ChIP-Seq_MCF-7_Human0.90885183
95HTT_18923047_ChIP-ChIP_STHdh_Human0.89696411
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89454777
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86372204
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86199824
99CBP_20019798_ChIP-Seq_JUKART_Human0.86199824
100HOXB7_26014856_ChIP-Seq_BT474_Human0.85023561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok3.37307282
2MP0002102_abnormal_ear_morphology3.15865615
3MP0008058_abnormal_DNA_repair3.14440625
4MP0005084_abnormal_gallbladder_morpholo3.14059000
5MP0000372_irregular_coat_pigmentation2.97561560
6MP0001984_abnormal_olfaction2.68049899
7MP0004885_abnormal_endolymph2.63926103
8MP0010094_abnormal_chromosome_stability2.50026107
9MP0001529_abnormal_vocalization2.43707778
10MP0003806_abnormal_nucleotide_metabolis2.30824128
11MP0003880_abnormal_central_pattern2.09067693
12MP0006072_abnormal_retinal_apoptosis2.07321974
13MP0003252_abnormal_bile_duct2.06087267
14MP0003646_muscle_fatigue1.87755401
15MP0008872_abnormal_physiological_respon1.82364724
16MP0003718_maternal_effect1.80853868
17MP0002160_abnormal_reproductive_system1.80555546
18MP0003195_calcinosis1.76789547
19MP0004957_abnormal_blastocyst_morpholog1.76786340
20MP0003786_premature_aging1.73805380
21MP0004147_increased_porphyrin_level1.71832534
22MP0006036_abnormal_mitochondrial_physio1.70412973
23MP0003186_abnormal_redox_activity1.68744021
24MP0004145_abnormal_muscle_electrophysio1.68012800
25MP0003693_abnormal_embryo_hatching1.61216873
26MP0005389_reproductive_system_phenotype1.60626771
27MP0005075_abnormal_melanosome_morpholog1.55834512
28MP0002938_white_spotting1.51722454
29MP0002837_dystrophic_cardiac_calcinosis1.49865135
30MP0008877_abnormal_DNA_methylation1.46963662
31MP0004133_heterotaxia1.42276120
32MP0003111_abnormal_nucleus_morphology1.42087259
33MP0001881_abnormal_mammary_gland1.40645279
34MP0001485_abnormal_pinna_reflex1.38745943
35MP0002006_tumorigenesis1.36161721
36MP0005551_abnormal_eye_electrophysiolog1.34791577
37MP0002928_abnormal_bile_duct1.31196225
38MP0001835_abnormal_antigen_presentation1.31127294
39MP0002638_abnormal_pupillary_reflex1.29456767
40MP0004142_abnormal_muscle_tone1.29314315
41MP0002095_abnormal_skin_pigmentation1.28921391
42MP0006035_abnormal_mitochondrial_morpho1.25384839
43MP0001293_anophthalmia1.24890425
44MP0005187_abnormal_penis_morphology1.23929061
45MP0005423_abnormal_somatic_nervous1.23249213
46MP0005377_hearing/vestibular/ear_phenot1.23069902
47MP0003878_abnormal_ear_physiology1.23069902
48MP0010234_abnormal_vibrissa_follicle1.16830386
49MP0005671_abnormal_response_to1.15843003
50MP0001968_abnormal_touch/_nociception1.15517919
51MP0003011_delayed_dark_adaptation1.15108553
52MP0010386_abnormal_urinary_bladder1.14240492
53MP0005379_endocrine/exocrine_gland_phen1.13695230
54MP0006292_abnormal_olfactory_placode1.12759763
55MP0006276_abnormal_autonomic_nervous1.12755176
56MP0008775_abnormal_heart_ventricle1.12583075
57MP0000647_abnormal_sebaceous_gland1.11231585
58MP0001905_abnormal_dopamine_level1.11000406
59MP0006054_spinal_hemorrhage1.07418336
60MP0005253_abnormal_eye_physiology1.05982214
61MP0004742_abnormal_vestibular_system1.05403039
62MP0009333_abnormal_splenocyte_physiolog1.04548839
63MP0002148_abnormal_hypersensitivity_rea1.02512066
64MP0002282_abnormal_trachea_morphology1.02151868
65MP0002735_abnormal_chemical_nociception1.00785031
66MP0005174_abnormal_tail_pigmentation1.00230927
67MP0000516_abnormal_urinary_system0.97471893
68MP0005367_renal/urinary_system_phenotyp0.97471893
69MP0009764_decreased_sensitivity_to0.96538808
70MP0001324_abnormal_eye_pigmentation0.93075544
71MP0002272_abnormal_nervous_system0.92995593
72MP0008995_early_reproductive_senescence0.92068386
73MP0000685_abnormal_immune_system0.90960962
74MP0002166_altered_tumor_susceptibility0.90690601
75MP0009046_muscle_twitch0.90679947
76MP0001986_abnormal_taste_sensitivity0.88963446
77MP0008007_abnormal_cellular_replicative0.88011154
78MP0000538_abnormal_urinary_bladder0.87756974
79MP0001929_abnormal_gametogenesis0.86891320
80MP0002163_abnormal_gland_morphology0.84853339
81MP0003950_abnormal_plasma_membrane0.84515803
82MP0003724_increased_susceptibility_to0.84122063
83MP0002736_abnormal_nociception_after0.83810551
84MP0002210_abnormal_sex_determination0.83407339
85MP0005410_abnormal_fertilization0.81912002
86MP0000653_abnormal_sex_gland0.79334424
87MP0003077_abnormal_cell_cycle0.76043724
88MP0008789_abnormal_olfactory_epithelium0.75644306
89MP0005408_hypopigmentation0.74853227
90MP0005332_abnormal_amino_acid0.74549760
91MP0005165_increased_susceptibility_to0.73134115
92MP0008932_abnormal_embryonic_tissue0.72868710
93MP0001727_abnormal_embryo_implantation0.72583299
94MP0003936_abnormal_reproductive_system0.72387482
95MP0000015_abnormal_ear_pigmentation0.72375447
96MP0001145_abnormal_male_reproductive0.71468836
97MP0001970_abnormal_pain_threshold0.71145836
98MP0009250_abnormal_appendicular_skeleto0.67958917
99MP0001919_abnormal_reproductive_system0.67529266
100MP0001790_abnormal_immune_system0.67232570

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.68014480
2Increased CSF lactate (HP:0002490)4.63370452
3Acute necrotizing encephalopathy (HP:0006965)4.57870052
4Hepatic necrosis (HP:0002605)4.53383627
5Hepatocellular necrosis (HP:0001404)4.47069225
6Increased hepatocellular lipid droplets (HP:0006565)4.45921750
7Lipid accumulation in hepatocytes (HP:0006561)4.03157213
8Acute encephalopathy (HP:0006846)4.01398727
9Abnormal mitochondria in muscle tissue (HP:0008316)3.95830426
10Progressive macrocephaly (HP:0004481)3.93486822
11Renal Fanconi syndrome (HP:0001994)3.59140759
12Increased serum lactate (HP:0002151)3.35431828
13Cerebral edema (HP:0002181)3.27161522
14Exertional dyspnea (HP:0002875)3.24974145
15Nephronophthisis (HP:0000090)3.07535858
16Increased serum pyruvate (HP:0003542)3.03878656
17Generalized aminoaciduria (HP:0002909)2.99049759
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92949483
19Abnormality of urine glucose concentration (HP:0011016)2.89156368
20Glycosuria (HP:0003076)2.89156368
21Abnormality of the labia minora (HP:0012880)2.84846785
22IgM deficiency (HP:0002850)2.83842174
23Optic disc pallor (HP:0000543)2.82194476
24Lactic acidosis (HP:0003128)2.82082753
25Increased intramyocellular lipid droplets (HP:0012240)2.78682241
26Respiratory failure (HP:0002878)2.67274300
27Abnormality of glycolysis (HP:0004366)2.64014000
28Degeneration of anterior horn cells (HP:0002398)2.57899887
29Abnormality of the anterior horn cell (HP:0006802)2.57899887
30Decreased central vision (HP:0007663)2.56108366
31Methylmalonic acidemia (HP:0002912)2.53567565
32Hyperglycinemia (HP:0002154)2.51088237
33Abnormality of the renal medulla (HP:0100957)2.50746536
34Respiratory difficulties (HP:0002880)2.50672166
35Colon cancer (HP:0003003)2.48201598
36Lethargy (HP:0001254)2.44885966
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44371196
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44371196
39Renal cortical cysts (HP:0000803)2.39056877
40Medial flaring of the eyebrow (HP:0010747)2.38646572
41Exercise intolerance (HP:0003546)2.36739512
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33559083
43Methylmalonic aciduria (HP:0012120)2.31493442
44CNS demyelination (HP:0007305)2.30344534
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.23878441
46Abnormality of glycine metabolism (HP:0010895)2.20753058
47Abnormality of serine family amino acid metabolism (HP:0010894)2.20753058
48Ependymoma (HP:0002888)2.20633350
49Abnormality of the vocal cords (HP:0008777)2.19864048
50Attenuation of retinal blood vessels (HP:0007843)2.19357134
51Nausea (HP:0002018)2.18731710
52Cerebral hypomyelination (HP:0006808)2.18450162
53Increased muscle lipid content (HP:0009058)2.18435271
54Abnormality of serum amino acid levels (HP:0003112)2.16268190
55Abnormality of the renal cortex (HP:0011035)2.15200881
56Congenital stationary night blindness (HP:0007642)2.10859105
57Abnormality of renal resorption (HP:0011038)2.09736445
58IgG deficiency (HP:0004315)2.09065809
59Abolished electroretinogram (ERG) (HP:0000550)2.08532374
60Molar tooth sign on MRI (HP:0002419)2.04952623
61Abnormality of midbrain morphology (HP:0002418)2.04952623
62Supernumerary spleens (HP:0009799)2.04061056
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02258912
64Congenital, generalized hypertrichosis (HP:0004540)2.00697187
65Hypoglycemic coma (HP:0001325)2.00450096
66Hypoplasia of the uterus (HP:0000013)1.97820437
67Pancytopenia (HP:0001876)1.95099956
68Stomatitis (HP:0010280)1.95013557
69Hyperphosphaturia (HP:0003109)1.94008855
70Pancreatic cysts (HP:0001737)1.91656668
71Hyperglycinuria (HP:0003108)1.90829321
72Leukodystrophy (HP:0002415)1.90176692
73Type I transferrin isoform profile (HP:0003642)1.89667922
74Abnormality of alanine metabolism (HP:0010916)1.89367923
75Hyperalaninemia (HP:0003348)1.89367923
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89367923
77Abnormality of B cell number (HP:0010975)1.87671264
78Type II lissencephaly (HP:0007260)1.85202857
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84625206
80Abnormal protein N-linked glycosylation (HP:0012347)1.84625206
81Abnormal protein glycosylation (HP:0012346)1.84625206
82Abnormal glycosylation (HP:0012345)1.84625206
83Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84179652
84Pendular nystagmus (HP:0012043)1.81076336
85Gonadotropin excess (HP:0000837)1.78238451
86Opisthotonus (HP:0002179)1.76475942
87Abnormality of T cell physiology (HP:0011840)1.75949871
88Neuroendocrine neoplasm (HP:0100634)1.75440673
89Gliosis (HP:0002171)1.72866431
90Hypothermia (HP:0002045)1.72711904
91Aplasia/hypoplasia of the uterus (HP:0008684)1.71982859
92Azoospermia (HP:0000027)1.71805866
93Emotional lability (HP:0000712)1.70281926
94Hypomagnesemia (HP:0002917)1.70148708
95Ketosis (HP:0001946)1.69294877
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69184558
97Neutropenia (HP:0001875)1.67699075
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65224181
99Dicarboxylic aciduria (HP:0003215)1.65224181
100Pachygyria (HP:0001302)1.65033171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.18724105
2VRK23.63752372
3ZAK3.49975614
4TLK13.15996209
5BUB13.06873421
6EIF2AK12.98675702
7NUAK12.94276294
8TAF12.55507498
9TSSK62.47504402
10TRIM282.31896063
11MST42.10128564
12VRK12.06591500
13PLK32.01396556
14FRK1.84368594
15PDK21.79380337
16NEK11.77555757
17BMPR1B1.70074556
18BCKDK1.62682385
19MKNK21.62312241
20MKNK11.59609822
21TAOK31.55607166
22EIF2AK21.50215734
23ADRBK21.47746046
24WNK41.46636227
25SRPK11.42572325
26PLK21.41560261
27OXSR11.29186550
28PBK1.25215089
29PHKG21.23115211
30PHKG11.23115211
31STK391.17091341
32PLK41.14761017
33STK161.14624555
34MAP3K141.13403065
35GRK11.12802805
36NME11.07762320
37GRK51.06371483
38DYRK21.05124288
39TTK1.04541362
40CSNK1G31.02884164
41KIT0.98713764
42PASK0.98127893
43CDK80.94181343
44CSNK1G10.93602489
45INSRR0.89822805
46TEC0.87954137
47WNK30.87790666
48MAP4K20.86990397
49TXK0.85256799
50PINK10.85181875
51MAP2K70.84700041
52TGFBR10.84317525
53STK240.82437469
54CSNK1G20.81741443
55ILK0.81066758
56PLK10.78395785
57SYK0.75870629
58ATR0.75459815
59ERBB30.75410000
60CSNK1A1L0.73219133
61ALK0.72801496
62MAPKAPK50.71931929
63CAMKK10.70976439
64CDC70.66759670
65DAPK10.65828594
66FES0.61115892
67BCR0.59225459
68TIE10.58392896
69CCNB10.56737076
70PRKCQ0.56086543
71TNIK0.55157834
72PRKCG0.55009019
73ADRBK10.53467561
74BRSK10.52818087
75PNCK0.52222442
76PIM20.51326997
77GRK60.50967040
78MAP3K120.50249622
79RPS6KA50.48767780
80CHEK20.47884887
81AURKB0.46964571
82MAP3K40.46801862
83ITK0.46497269
84WEE10.45070286
85AURKA0.42920666
86PRKCI0.42573792
87FGFR20.41241543
88ATM0.40569684
89CSNK2A10.40187668
90MAPK130.39757720
91MYLK0.35055805
92DAPK30.35013565
93EPHA30.34140961
94PRKCE0.33251862
95CDK30.32345083
96PRKCA0.30029727
97CSNK2A20.29733452
98DYRK1A0.28919135
99MAPKAPK30.28784296
100ACVR1B0.28201682

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.29756897
2Oxidative phosphorylation_Homo sapiens_hsa001903.51618496
3Caffeine metabolism_Homo sapiens_hsa002323.26663484
4Protein export_Homo sapiens_hsa030603.13898282
5Parkinsons disease_Homo sapiens_hsa050123.13506814
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35818188
7Asthma_Homo sapiens_hsa053102.35817533
8Ribosome_Homo sapiens_hsa030102.27007763
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04117051
10Mismatch repair_Homo sapiens_hsa034301.99185455
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.91339689
12Alzheimers disease_Homo sapiens_hsa050101.90589233
13Huntingtons disease_Homo sapiens_hsa050161.90268404
14Propanoate metabolism_Homo sapiens_hsa006401.77105393
15DNA replication_Homo sapiens_hsa030301.76254198
16One carbon pool by folate_Homo sapiens_hsa006701.73352050
17RNA polymerase_Homo sapiens_hsa030201.64060717
18Allograft rejection_Homo sapiens_hsa053301.62092708
19Non-homologous end-joining_Homo sapiens_hsa034501.61613815
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59981876
21Nitrogen metabolism_Homo sapiens_hsa009101.58005188
22Homologous recombination_Homo sapiens_hsa034401.51650484
23Autoimmune thyroid disease_Homo sapiens_hsa053201.50236162
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49360493
25Basal transcription factors_Homo sapiens_hsa030221.47719619
26RNA degradation_Homo sapiens_hsa030181.46926985
27Base excision repair_Homo sapiens_hsa034101.42299666
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38453749
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35813669
30Graft-versus-host disease_Homo sapiens_hsa053321.35358082
31Type I diabetes mellitus_Homo sapiens_hsa049401.34149694
32Nucleotide excision repair_Homo sapiens_hsa034201.31790711
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28651750
34Phototransduction_Homo sapiens_hsa047441.22230861
35Spliceosome_Homo sapiens_hsa030401.21595794
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18966713
37Purine metabolism_Homo sapiens_hsa002301.13809158
38Butanoate metabolism_Homo sapiens_hsa006501.10573790
39Cardiac muscle contraction_Homo sapiens_hsa042601.10226980
40RNA transport_Homo sapiens_hsa030131.09721681
41Pyruvate metabolism_Homo sapiens_hsa006201.05613256
42Fanconi anemia pathway_Homo sapiens_hsa034600.99669798
43Pyrimidine metabolism_Homo sapiens_hsa002400.96853141
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.96422080
45Fatty acid elongation_Homo sapiens_hsa000620.95011645
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94179687
47Antigen processing and presentation_Homo sapiens_hsa046120.92281015
48Systemic lupus erythematosus_Homo sapiens_hsa053220.89936650
49Tryptophan metabolism_Homo sapiens_hsa003800.89808678
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84393764
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83518407
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83217364
53Rheumatoid arthritis_Homo sapiens_hsa053230.79885281
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79878507
55Peroxisome_Homo sapiens_hsa041460.78586535
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.77398664
57Linoleic acid metabolism_Homo sapiens_hsa005910.74540735
58Sulfur relay system_Homo sapiens_hsa041220.72231319
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71515703
60Metabolic pathways_Homo sapiens_hsa011000.70605505
61Folate biosynthesis_Homo sapiens_hsa007900.67808463
62Chemical carcinogenesis_Homo sapiens_hsa052040.65399585
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63441434
64Sulfur metabolism_Homo sapiens_hsa009200.60870649
65Steroid biosynthesis_Homo sapiens_hsa001000.60248302
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58897310
67Primary immunodeficiency_Homo sapiens_hsa053400.58045286
68Collecting duct acid secretion_Homo sapiens_hsa049660.57345529
69Vitamin B6 metabolism_Homo sapiens_hsa007500.56620214
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56553193
71p53 signaling pathway_Homo sapiens_hsa041150.56172388
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54391309
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52633801
74Oocyte meiosis_Homo sapiens_hsa041140.50622349
75Regulation of autophagy_Homo sapiens_hsa041400.50086474
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49333395
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.47503484
78Glutathione metabolism_Homo sapiens_hsa004800.46215464
79Ether lipid metabolism_Homo sapiens_hsa005650.45937822
80Arachidonic acid metabolism_Homo sapiens_hsa005900.44573056
81Vitamin digestion and absorption_Homo sapiens_hsa049770.44554033
82Olfactory transduction_Homo sapiens_hsa047400.43245024
83beta-Alanine metabolism_Homo sapiens_hsa004100.42954855
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.41809857
85Epstein-Barr virus infection_Homo sapiens_hsa051690.40803981
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39345977
87Carbon metabolism_Homo sapiens_hsa012000.38154891
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36972202
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36085866
90Morphine addiction_Homo sapiens_hsa050320.34618449
91Cell cycle_Homo sapiens_hsa041100.34096491
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33561627
93Ovarian steroidogenesis_Homo sapiens_hsa049130.33488028
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32981176
95Viral myocarditis_Homo sapiens_hsa054160.32773161
96Fatty acid degradation_Homo sapiens_hsa000710.31200273
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30930204
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.30579423
99Starch and sucrose metabolism_Homo sapiens_hsa005000.29831592
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29350132

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »