SLC25A48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.30588136
2DNA deamination (GO:0045006)5.93042887
3sulfation (GO:0051923)5.91166218
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.45508800
5L-phenylalanine catabolic process (GO:0006559)5.45508800
6behavioral response to nicotine (GO:0035095)5.42744762
7aromatic amino acid family catabolic process (GO:0009074)5.41512649
8membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.41037907
9indole-containing compound catabolic process (GO:0042436)5.39324949
10indolalkylamine catabolic process (GO:0046218)5.39324949
11tryptophan catabolic process (GO:0006569)5.39324949
12L-phenylalanine metabolic process (GO:0006558)5.08288048
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.08288048
14water-soluble vitamin biosynthetic process (GO:0042364)5.05806479
15tryptophan metabolic process (GO:0006568)5.05217674
16amino-acid betaine metabolic process (GO:0006577)5.04139112
17membrane repolarization during action potential (GO:0086011)4.88447809
18cellular biogenic amine catabolic process (GO:0042402)4.56194575
19amine catabolic process (GO:0009310)4.56194575
20cellular response to ATP (GO:0071318)4.54157053
21kynurenine metabolic process (GO:0070189)4.50786876
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.49236805
23cysteine metabolic process (GO:0006534)4.48871429
24sulfur amino acid catabolic process (GO:0000098)4.47391244
25bile acid biosynthetic process (GO:0006699)4.42049615
26regulation of glomerulus development (GO:0090192)4.40637417
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.30633395
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.30633395
29NADH dehydrogenase complex assembly (GO:0010257)4.30633395
30urea metabolic process (GO:0019627)4.27398417
31urea cycle (GO:0000050)4.27398417
32glyoxylate metabolic process (GO:0046487)4.16408854
33homocysteine metabolic process (GO:0050667)4.12138374
34protein carboxylation (GO:0018214)4.12021973
35peptidyl-glutamic acid carboxylation (GO:0017187)4.12021973
36regulation of cell proliferation involved in kidney development (GO:1901722)4.08670336
37cell proliferation in forebrain (GO:0021846)4.03230305
38negative regulation of systemic arterial blood pressure (GO:0003085)4.02676001
39urate metabolic process (GO:0046415)4.01863777
40carnitine metabolic process (GO:0009437)4.01515672
41serine family amino acid catabolic process (GO:0009071)3.98937406
42positive regulation of potassium ion transmembrane transport (GO:1901381)3.98519480
43indolalkylamine metabolic process (GO:0006586)3.97411235
44purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.93713391
453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.93713391
46nitrogen cycle metabolic process (GO:0071941)3.92770026
47positive regulation of cardiac muscle cell differentiation (GO:2000727)3.91620448
48drug catabolic process (GO:0042737)3.87531354
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.86253387
50aromatic amino acid family metabolic process (GO:0009072)3.85256177
51bile acid metabolic process (GO:0008206)3.83555680
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.83405297
53imidazole-containing compound metabolic process (GO:0052803)3.82799192
54high-density lipoprotein particle remodeling (GO:0034375)3.80838211
55regulation of skeletal muscle contraction (GO:0014819)3.79032503
56cellular potassium ion homeostasis (GO:0030007)3.78880155
57lysine catabolic process (GO:0006554)3.67991346
58lysine metabolic process (GO:0006553)3.67991346
59magnesium ion transport (GO:0015693)3.66771748
60regulation of fibrinolysis (GO:0051917)3.62272994
61negative regulation of mast cell activation (GO:0033004)3.61386254
62negative regulation of keratinocyte proliferation (GO:0010839)3.60923679
63fibrinolysis (GO:0042730)3.60922057
64protein complex biogenesis (GO:0070271)3.60185618
65regulation of cholesterol esterification (GO:0010872)3.57827284
66gamma-aminobutyric acid transport (GO:0015812)3.53095437
67positive regulation of cAMP-mediated signaling (GO:0043950)3.52537641
68bile acid and bile salt transport (GO:0015721)3.51394312
69regulation of bile acid biosynthetic process (GO:0070857)3.49632699
70purine ribonucleotide transport (GO:0015868)3.49519683
71negative regulation of lipase activity (GO:0060192)3.47981385
72phospholipid efflux (GO:0033700)3.46601298
73triglyceride homeostasis (GO:0070328)3.45803382
74acylglycerol homeostasis (GO:0055090)3.45803382
75alpha-amino acid catabolic process (GO:1901606)3.43999056
76hemidesmosome assembly (GO:0031581)3.43004193
77positive regulation of fatty acid oxidation (GO:0046321)3.41944518
78membrane repolarization (GO:0086009)3.41384600
79cellular ketone body metabolic process (GO:0046950)3.40823745
80benzene-containing compound metabolic process (GO:0042537)3.39268051
81tyrosine metabolic process (GO:0006570)3.39048366
82regulation of mesoderm development (GO:2000380)3.37814275
83desmosome organization (GO:0002934)3.36630881
84negative regulation of fibrinolysis (GO:0051918)3.36251297
85regulation of triglyceride catabolic process (GO:0010896)3.36024861
86cellular glucuronidation (GO:0052695)3.34969741
87regulation of protein activation cascade (GO:2000257)3.34622264
88cellular response to exogenous dsRNA (GO:0071360)3.34173527
89xenobiotic catabolic process (GO:0042178)3.32148239
90complement activation, alternative pathway (GO:0006957)3.31467150
91positive regulation of triglyceride biosynthetic process (GO:0010867)3.31219378
92drug transmembrane transport (GO:0006855)3.28276083
93cellular amino acid catabolic process (GO:0009063)3.26635194
94mitochondrial respiratory chain complex assembly (GO:0033108)3.26490841
95linoleic acid metabolic process (GO:0043651)3.24877752
96cellular anion homeostasis (GO:0030002)3.24671877
97negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23726038
98pharyngeal system development (GO:0060037)3.22565934
99cellular modified amino acid catabolic process (GO:0042219)3.22503957
100plasma lipoprotein particle remodeling (GO:0034369)3.20032939
101protein-lipid complex remodeling (GO:0034368)3.20032939
102macromolecular complex remodeling (GO:0034367)3.20032939
103glutathione derivative biosynthetic process (GO:1901687)3.18837146
104glutathione derivative metabolic process (GO:1901685)3.18837146
105regulation of membrane repolarization (GO:0060306)3.17379457
106protein polyglutamylation (GO:0018095)3.16904078
107alpha-linolenic acid metabolic process (GO:0036109)3.16372160
108NAD biosynthetic process (GO:0009435)3.15879592
109reverse cholesterol transport (GO:0043691)3.14414519
110glucuronate metabolic process (GO:0019585)3.14217118
111uronic acid metabolic process (GO:0006063)3.14217118
112membrane depolarization during action potential (GO:0086010)3.12234928
113regulation of complement activation (GO:0030449)3.10505714
114exogenous drug catabolic process (GO:0042738)3.09959391
115diterpenoid biosynthetic process (GO:0016102)3.09950824
116purine nucleotide transport (GO:0015865)3.09171942
117response to nitrosative stress (GO:0051409)3.09154686
118positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.04964482
119nicotinamide nucleotide biosynthetic process (GO:0019359)3.03535097
120pyridine nucleotide biosynthetic process (GO:0019363)3.03535097
121arginine metabolic process (GO:0006525)3.01035237
122regulation of posttranscriptional gene silencing (GO:0060147)3.00656415
123regulation of gene silencing by miRNA (GO:0060964)3.00656415
124regulation of gene silencing by RNA (GO:0060966)3.00656415
125organic acid catabolic process (GO:0016054)3.00617828
126carboxylic acid catabolic process (GO:0046395)3.00617828
127coenzyme catabolic process (GO:0009109)3.00012736
128somite development (GO:0061053)2.99522062
129ovulation from ovarian follicle (GO:0001542)2.97714626
130sphingoid metabolic process (GO:0046519)2.96444653
131lung morphogenesis (GO:0060425)2.95473871
132low-density lipoprotein particle remodeling (GO:0034374)2.94690668
133cAMP catabolic process (GO:0006198)2.93782378
134regulation of female receptivity (GO:0045924)2.93343496
135negative regulation of cholesterol transport (GO:0032375)2.92699219
136negative regulation of sterol transport (GO:0032372)2.92699219
137interferon-gamma secretion (GO:0072643)2.92570947
138DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91189972
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.90536112
140short-chain fatty acid metabolic process (GO:0046459)2.90035546
141negative regulation of telomere maintenance (GO:0032205)2.89645576
142flavonoid metabolic process (GO:0009812)2.88262142
143lymphangiogenesis (GO:0001946)2.87821124
144negative regulation of blood coagulation (GO:0030195)2.86923237
145negative regulation of hemostasis (GO:1900047)2.86923237
146cytidine deamination (GO:0009972)2.86775118
147cytidine metabolic process (GO:0046087)2.86775118
148cytidine catabolic process (GO:0006216)2.86775118
149L-ascorbic acid metabolic process (GO:0019852)2.85877872
150serotonin metabolic process (GO:0042428)2.85693143
151aldehyde catabolic process (GO:0046185)2.85420404
152negative regulation of response to food (GO:0032096)2.85140800
153negative regulation of appetite (GO:0032099)2.85140800
154very-low-density lipoprotein particle assembly (GO:0034379)2.84660742
155regulation of phospholipid biosynthetic process (GO:0071071)2.84458965
156drug transport (GO:0015893)2.84309796
157ketone body metabolic process (GO:1902224)2.83541618
158organ formation (GO:0048645)2.83473357
159serine family amino acid metabolic process (GO:0009069)2.83276644
160regulation of germinal center formation (GO:0002634)2.81258260
161middle ear morphogenesis (GO:0042474)2.80971132
162transepithelial transport (GO:0070633)2.79145278
163regulation of DNA endoreduplication (GO:0032875)2.78990345
164response to xenobiotic stimulus (GO:0009410)2.78439030
165replicative senescence (GO:0090399)2.77874486
166pituitary gland development (GO:0021983)2.76636199
167positive regulation of defense response to virus by host (GO:0002230)2.75555888
168indole-containing compound metabolic process (GO:0042430)2.74155480
169potassium ion import (GO:0010107)2.72686782
170mesonephros development (GO:0001823)2.71768522
171vitamin biosynthetic process (GO:0009110)2.71643477
172epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.68470147
173dentate gyrus development (GO:0021542)2.67868011
174parturition (GO:0007567)2.67481447
175artery development (GO:0060840)2.67062778
176organ induction (GO:0001759)2.66837773
177preassembly of GPI anchor in ER membrane (GO:0016254)2.62994891
178response to lipoprotein particle (GO:0055094)2.62906596
179primary amino compound metabolic process (GO:1901160)2.62331072
180endoderm formation (GO:0001706)2.60930261
181intestinal epithelial cell development (GO:0060576)2.60789026
182dopamine transport (GO:0015872)2.60583977
183regulation of heart rate by cardiac conduction (GO:0086091)2.60435110
184embryonic skeletal joint morphogenesis (GO:0060272)2.59206405
185cyclic nucleotide catabolic process (GO:0009214)2.59024699
186relaxation of cardiac muscle (GO:0055119)2.59003165
187negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.58171969
188GPI anchor metabolic process (GO:0006505)2.57467017
189negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56715132
190regulation of hippo signaling (GO:0035330)2.56147742
191regulation of action potential (GO:0098900)2.54648779
192response to UV-C (GO:0010225)2.53621630
193neuronal action potential (GO:0019228)2.53333465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.73875974
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.79793295
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.81612605
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.75045158
5EZH2_22144423_ChIP-Seq_EOC_Human4.66244180
6RXR_22158963_ChIP-Seq_LIVER_Mouse4.41587573
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.68761787
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.61857128
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.55179961
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.42474098
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.92673120
12VDR_22108803_ChIP-Seq_LS180_Human2.88869745
13* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.52245320
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.45173544
15ZNF274_21170338_ChIP-Seq_K562_Hela2.43709968
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28856066
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28015467
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.18914552
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13671548
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13071986
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07658509
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04673462
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.04318536
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.01935753
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93517400
26KAP1_22055183_ChIP-Seq_ESCs_Mouse1.87036910
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84716884
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80077588
29IRF1_19129219_ChIP-ChIP_H3396_Human1.79904027
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78190727
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77646429
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.70424425
33EWS_26573619_Chip-Seq_HEK293_Human1.69661624
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69618560
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67062508
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.64224834
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63907261
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.61279575
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.61114173
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60840845
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60298517
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.56373410
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56035805
44RNF2_27304074_Chip-Seq_NSC_Mouse1.55236974
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53560105
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.53253673
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52505913
48FUS_26573619_Chip-Seq_HEK293_Human1.51142099
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50844839
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49910695
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49357135
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48720999
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48261613
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.48173248
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47387079
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47188685
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.45778270
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45619307
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45223166
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45157795
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43727964
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43727964
63IGF1R_20145208_ChIP-Seq_DFB_Human1.42681873
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40888353
65GBX2_23144817_ChIP-Seq_PC3_Human1.40876780
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.37504934
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34333054
68MYC_18940864_ChIP-ChIP_HL60_Human1.33518884
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33280325
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33275095
71REST_21632747_ChIP-Seq_MESCs_Mouse1.30878160
72HTT_18923047_ChIP-ChIP_STHdh_Human1.28898495
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28345374
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27975641
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.27567190
76CJUN_26792858_Chip-Seq_BT549_Human1.27427648
77SOX2_20726797_ChIP-Seq_SW620_Human1.26507781
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25726233
79TP53_18474530_ChIP-ChIP_U2OS_Human1.25300091
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.24634854
81ER_23166858_ChIP-Seq_MCF-7_Human1.24246320
82* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23816234
83FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23340219
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22119278
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.22072023
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.22042257
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21884221
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20869448
89GATA4_25053715_ChIP-Seq_YYC3_Human1.19582387
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18518330
91CDX2_22108803_ChIP-Seq_LS180_Human1.16027220
92CBP_20019798_ChIP-Seq_JUKART_Human1.15482068
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15482068
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13917044
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12740244
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.12375146
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11954528
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11795519
99TP63_23658742_ChIP-Seq_EP156T_Human1.11776864
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11617770
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10909643
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.10777429
103AR_21572438_ChIP-Seq_LNCaP_Human1.10383263
104AR_25329375_ChIP-Seq_VCAP_Human1.10340465
105STAT3_23295773_ChIP-Seq_U87_Human1.10001941
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.09878846
107BCAT_22108803_ChIP-Seq_LS180_Human1.09445590
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09367565
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.09342141
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09342141
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.09118966
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07929102
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.07573964
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07375245
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07333486
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.06728425
117P53_22387025_ChIP-Seq_ESCs_Mouse1.06657490
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05956598
119RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05907671
120STAT1_17558387_ChIP-Seq_HELA_Human1.05900097
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05623026
122SMAD4_21799915_ChIP-Seq_A2780_Human1.05242919
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.05157603
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.04832337
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03973152
126TAF15_26573619_Chip-Seq_HEK293_Human1.03675177
127TCF4_23295773_ChIP-Seq_U87_Human1.03507120
128NMYC_18555785_Chip-Seq_ESCs_Mouse1.03434587
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.03025922
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02616877
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01943640
132NANOG_19829295_ChIP-Seq_ESCs_Human1.01544712
133SOX2_19829295_ChIP-Seq_ESCs_Human1.01544712
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.01374369
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01002110
136RING1B_27294783_Chip-Seq_ESCs_Mouse1.00895949
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00410383
138KDM2B_26808549_Chip-Seq_REH_Human1.00072175
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.99806732
140KLF4_18555785_Chip-Seq_ESCs_Mouse0.99695006
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99473620
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99277346
143ZFX_18555785_Chip-Seq_ESCs_Mouse0.99218774
144SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98244052
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98192622
146SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97948648
147TP53_22573176_ChIP-Seq_HFKS_Human0.97928259
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.97454908
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.97321824
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.97315666
151IRF8_22096565_ChIP-ChIP_GC-B_Human0.96518069
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95892375
153AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95662978
154ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95140113
155GATA6_21074721_ChIP-Seq_CACO-2_Human0.93854157
156HNFA_21074721_ChIP-Seq_CACO-2_Human0.93825408
157TP53_16413492_ChIP-PET_HCT116_Human0.93683568
158NCOR_22424771_ChIP-Seq_293T_Human0.93590097
159LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93432513
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92400517
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.92312543
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92236953
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92236953
164TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92076061
165CMYC_18555785_Chip-Seq_ESCs_Mouse0.91893988
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91794699
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91177149
168GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91075740
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91073720
170CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91057887
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.90584412
172SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90454816
173PHF8_20622853_ChIP-Seq_HELA_Human0.90182326
174FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89691381
175P300_18555785_Chip-Seq_ESCs_Mouse0.89174165
176SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88118028
177AHR_22903824_ChIP-Seq_MCF-7_Human0.87440244
178CTCF_18555785_Chip-Seq_ESCs_Mouse0.87401709
179OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87345492
180P300_19829295_ChIP-Seq_ESCs_Human0.86994262
181CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86705314
182STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86536347
183PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86442949
184PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85658054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.86754594
2MP0002139_abnormal_hepatobiliary_system5.34008266
3MP0002254_reproductive_system_inflammat5.22223620
4MP0003283_abnormal_digestive_organ4.83858190
5MP0005085_abnormal_gallbladder_physiolo4.34500311
6MP0005365_abnormal_bile_salt3.89460343
7MP0005451_abnormal_body_composition3.44878217
8MP0008875_abnormal_xenobiotic_pharmacok3.44305353
9MP0000566_synostosis3.22707732
10MP0004885_abnormal_endolymph2.99190401
11MP0004381_abnormal_hair_follicle2.72513140
12MP0001485_abnormal_pinna_reflex2.66950275
13MP0004134_abnormal_chest_morphology2.61508986
14MP0000049_abnormal_middle_ear2.55208637
15MP0002160_abnormal_reproductive_system2.52916029
16MP0003195_calcinosis2.50757875
17MP0004019_abnormal_vitamin_homeostasis2.47924272
18MP0003718_maternal_effect2.47672549
19MP0003252_abnormal_bile_duct2.41940519
20MP0002796_impaired_skin_barrier2.33922171
21MP0000579_abnormal_nail_morphology2.30458852
22MP0001968_abnormal_touch/_nociception2.21099189
23MP0000631_abnormal_neuroendocrine_gland2.20561970
24MP0003941_abnormal_skin_development2.16475911
25MP0003136_yellow_coat_color2.12483496
26MP0008872_abnormal_physiological_respon2.12312716
27MP0002102_abnormal_ear_morphology2.09982057
28MP0004145_abnormal_muscle_electrophysio2.06970138
29MP0010234_abnormal_vibrissa_follicle2.06218999
30MP0001666_abnormal_nutrient_absorption2.05564965
31MP0002272_abnormal_nervous_system2.03926247
32MP0000383_abnormal_hair_follicle2.02270019
33MP0005408_hypopigmentation1.98871610
34MP0003806_abnormal_nucleotide_metabolis1.96913378
35MP0008877_abnormal_DNA_methylation1.96410420
36MP0005332_abnormal_amino_acid1.93797610
37MP0004782_abnormal_surfactant_physiolog1.86237366
38MP0005551_abnormal_eye_electrophysiolog1.79926089
39MP0004142_abnormal_muscle_tone1.78538710
40MP0010329_abnormal_lipoprotein_level1.77974849
41MP0009697_abnormal_copulation1.77948624
42MP0010678_abnormal_skin_adnexa1.76095428
43MP0003119_abnormal_digestive_system1.75278837
44MP0003879_abnormal_hair_cell1.73913274
45MP0004130_abnormal_muscle_cell1.72401409
46MP0009745_abnormal_behavioral_response1.70566481
47MP0003453_abnormal_keratinocyte_physiol1.68948133
48MP0002138_abnormal_hepatobiliary_system1.68071358
49MP0002837_dystrophic_cardiac_calcinosis1.66836421
50MP0006072_abnormal_retinal_apoptosis1.66131212
51MP0001440_abnormal_grooming_behavior1.65933235
52MP0002736_abnormal_nociception_after1.65023977
53MP0009046_muscle_twitch1.64783378
54MP0002735_abnormal_chemical_nociception1.63483467
55MP0009250_abnormal_appendicular_skeleto1.62513613
56MP0004133_heterotaxia1.60115813
57MP0002060_abnormal_skin_morphology1.59934744
58MP0003646_muscle_fatigue1.59655016
59MP0002098_abnormal_vibrissa_morphology1.58592494
60MP0009780_abnormal_chondrocyte_physiolo1.51094103
61MP0002733_abnormal_thermal_nociception1.45746104
62MP0009840_abnormal_foam_cell1.42413410
63MP0002064_seizures1.42335256
64MP0003868_abnormal_feces_composition1.40272011
65MP0001216_abnormal_epidermal_layer1.39789917
66MP0003191_abnormal_cellular_cholesterol1.38552200
67MP0005395_other_phenotype1.36490823
68MP0003938_abnormal_ear_development1.34134223
69MP0001905_abnormal_dopamine_level1.33624403
70MP0002734_abnormal_mechanical_nocicepti1.33183630
71MP0005501_abnormal_skin_physiology1.28962168
72MP0005084_abnormal_gallbladder_morpholo1.28817624
73MP0009643_abnormal_urine_homeostasis1.28614354
74MP0001970_abnormal_pain_threshold1.27410647
75MP0000427_abnormal_hair_cycle1.26096480
76MP0002132_abnormal_respiratory_system1.24391640
77MP0000647_abnormal_sebaceous_gland1.24033319
78MP0003186_abnormal_redox_activity1.23592590
79MP0009764_decreased_sensitivity_to1.18205571
80MP0000377_abnormal_hair_follicle1.17352590
81MP0005647_abnormal_sex_gland1.16751799
82MP0003937_abnormal_limbs/digits/tail_de1.14504764
83MP0002751_abnormal_autonomic_nervous1.14139663
84MP0001346_abnormal_lacrimal_gland1.13836756
85MP0004742_abnormal_vestibular_system1.12455148
86MP0000538_abnormal_urinary_bladder1.11283178
87MP0000613_abnormal_salivary_gland1.10180562
88MP0001119_abnormal_female_reproductive1.09550821
89MP0001986_abnormal_taste_sensitivity1.09249498
90MP0010368_abnormal_lymphatic_system1.08768196
91MP0003011_delayed_dark_adaptation1.08743104
92MP0005253_abnormal_eye_physiology1.07070885
93MP0005174_abnormal_tail_pigmentation1.05769490
94MP0009384_cardiac_valve_regurgitation1.04821464
95MP0002118_abnormal_lipid_homeostasis1.04492191
96MP0001881_abnormal_mammary_gland1.04262107
97MP0005083_abnormal_biliary_tract1.04207847
98MP0003635_abnormal_synaptic_transmissio1.02830956
99MP0000467_abnormal_esophagus_morphology1.02228639
100MP0009379_abnormal_foot_pigmentation1.01262461
101MP0010771_integument_phenotype1.01064319
102MP0000013_abnormal_adipose_tissue1.00240237
103MP0005379_endocrine/exocrine_gland_phen1.00095525
104MP0001963_abnormal_hearing_physiology0.99831662
105MP0002063_abnormal_learning/memory/cond0.99160490
106MP0002876_abnormal_thyroid_physiology0.98900426
107MP0000609_abnormal_liver_physiology0.98604887
108MP0000026_abnormal_inner_ear0.97877082
109MP0004264_abnormal_extraembryonic_tissu0.97088364
110MP0001919_abnormal_reproductive_system0.96551409
111MP0005636_abnormal_mineral_homeostasis0.96219752
112MP0001486_abnormal_startle_reflex0.95750855
113MP0003567_abnormal_fetal_cardiomyocyte0.94852906
114MP0005671_abnormal_response_to0.94569881
115MP0002653_abnormal_ependyma_morphology0.94343700
116MP0002572_abnormal_emotion/affect_behav0.94219713
117MP0001756_abnormal_urination0.90507127
118MP0003699_abnormal_female_reproductive0.89375685
119MP0002638_abnormal_pupillary_reflex0.88302600
120MP0000762_abnormal_tongue_morphology0.85533936
121MP0000627_abnormal_mammary_gland0.84936434
122MP0000678_abnormal_parathyroid_gland0.84672224
123MP0005670_abnormal_white_adipose0.84576876
124MP0005389_reproductive_system_phenotype0.84495721
125MP0006276_abnormal_autonomic_nervous0.83959568
126MP0000230_abnormal_systemic_arterial0.83127538
127MP0003724_increased_susceptibility_to0.83024442
128MP0001764_abnormal_homeostasis0.80457916
129MP0001502_abnormal_circadian_rhythm0.80413771
130MP0005319_abnormal_enzyme/_coenzyme0.80095424
131MP0002557_abnormal_social/conspecific_i0.79898790
132MP0002277_abnormal_respiratory_mucosa0.79506382
133MP0002136_abnormal_kidney_physiology0.79354688
134MP0005195_abnormal_posterior_eye0.78670275
135MP0002938_white_spotting0.78255059
136MP0006292_abnormal_olfactory_placode0.78193828
137MP0001501_abnormal_sleep_pattern0.77374117
138MP0001879_abnormal_lymphatic_vessel0.75080863
139MP0003942_abnormal_urinary_system0.74286292
140MP0002067_abnormal_sensory_capabilities0.74175615
141MP0005646_abnormal_pituitary_gland0.74021968
142MP0009053_abnormal_anal_canal0.72634915
143MP0002295_abnormal_pulmonary_circulatio0.72467820
144MP0009765_abnormal_xenobiotic_induced0.71745924
145MP0002752_abnormal_somatic_nervous0.71451555
146MP0002089_abnormal_postnatal_growth/wei0.71193931
147MP0002249_abnormal_larynx_morphology0.70954773
148MP0003880_abnormal_central_pattern0.70261503
149MP0004947_skin_inflammation0.69638372
150MP0005367_renal/urinary_system_phenotyp0.69615169
151MP0000516_abnormal_urinary_system0.69615169
152MP0002116_abnormal_craniofacial_bone0.68887693
153MP0000372_irregular_coat_pigmentation0.67925277
154MP0000163_abnormal_cartilage_morphology0.67365774
155MP0001191_abnormal_skin_condition0.66585630
156MP0004215_abnormal_myocardial_fiber0.66334356
157MP0005645_abnormal_hypothalamus_physiol0.66114415
158MP0003936_abnormal_reproductive_system0.63804013
159MP0005584_abnormal_enzyme/coenzyme_acti0.61416439
160MP0002163_abnormal_gland_morphology0.61411223
161MP0001765_abnormal_ion_homeostasis0.59747284
162MP0006082_CNS_inflammation0.59740284
163MP0003638_abnormal_response/metabolism_0.59257850
164MP0003705_abnormal_hypodermis_morpholog0.56824479
165MP0000367_abnormal_coat/_hair0.55479431
166MP0009931_abnormal_skin_appearance0.54262902
167MP0002282_abnormal_trachea_morphology0.53042044
168MP0005220_abnormal_exocrine_pancreas0.52590255
169MP0005187_abnormal_penis_morphology0.52018228
170MP0008469_abnormal_protein_level0.51965922
171MP0005275_abnormal_skin_tensile0.50670208
172MP0010386_abnormal_urinary_bladder0.50060523
173MP0009642_abnormal_blood_homeostasis0.49979165
174MP0009763_increased_sensitivity_to0.49433968
175MP0004043_abnormal_pH_regulation0.49229253
176MP0002928_abnormal_bile_duct0.48727567

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.95015261
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.47630949
3Deep venous thrombosis (HP:0002625)4.34054755
4Prolonged partial thromboplastin time (HP:0003645)4.30181157
5Clumsiness (HP:0002312)4.08864595
6Onycholysis (HP:0001806)4.04709321
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.01640977
8Pendular nystagmus (HP:0012043)3.85887214
9Xanthomatosis (HP:0000991)3.73509050
10Genetic anticipation (HP:0003743)3.73039638
11Hyperglycinuria (HP:0003108)3.59898188
12Joint hemorrhage (HP:0005261)3.59040147
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.57879984
14Abnormality of aspartate family amino acid metabolism (HP:0010899)3.40073341
15Methylmalonic acidemia (HP:0002912)3.38042149
16Abolished electroretinogram (ERG) (HP:0000550)3.37354172
17Pancreatic cysts (HP:0001737)3.30783121
18Megalencephaly (HP:0001355)3.25277824
19Hyperglycinemia (HP:0002154)3.15286734
20Parakeratosis (HP:0001036)3.15250917
21Abnormality of the proximal phalanges of the hand (HP:0009834)3.11903634
22Alopecia of scalp (HP:0002293)3.08604879
23Progressive cerebellar ataxia (HP:0002073)3.07828614
24Hyperlipoproteinemia (HP:0010980)3.07405708
25Abnormality of glycine metabolism (HP:0010895)3.06932971
26Abnormality of serine family amino acid metabolism (HP:0010894)3.06932971
27Congenital, generalized hypertrichosis (HP:0004540)3.06929631
28Methylmalonic aciduria (HP:0012120)3.01845491
29Hypobetalipoproteinemia (HP:0003563)2.97666979
30Lip pit (HP:0100267)2.97027052
31Pancreatic fibrosis (HP:0100732)2.96718302
32Conjugated hyperbilirubinemia (HP:0002908)2.94914022
33Hyperammonemia (HP:0001987)2.89370746
34Short 1st metacarpal (HP:0010034)2.88506047
35Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.88506047
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.87613740
37Congenital sensorineural hearing impairment (HP:0008527)2.87534607
38Abnormality of methionine metabolism (HP:0010901)2.84383050
39Fat malabsorption (HP:0002630)2.83096566
40True hermaphroditism (HP:0010459)2.81688466
41Plantar hyperkeratosis (HP:0007556)2.79671366
42Fragile nails (HP:0001808)2.79030703
43Abnormality of pyrimidine metabolism (HP:0004353)2.77780652
44Congenital stationary night blindness (HP:0007642)2.74337042
45Abnormality of the middle phalanges of the toes (HP:0010183)2.72312720
46Nephronophthisis (HP:0000090)2.71427579
47Keratoconus (HP:0000563)2.70482597
48Increased corneal curvature (HP:0100692)2.70482597
49Asplenia (HP:0001746)2.69096564
50Milia (HP:0001056)2.66221819
51Abnormality of the renal collecting system (HP:0004742)2.64352252
52Epidermoid cyst (HP:0200040)2.63253786
53Vascular calcification (HP:0004934)2.61908197
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.60724138
55Abnormality of DNA repair (HP:0003254)2.60669930
56Decreased central vision (HP:0007663)2.58389611
57Hypotrichosis (HP:0001006)2.58066129
58Short hallux (HP:0010109)2.57986939
59Abnormality of the phalanges of the 2nd finger (HP:0009541)2.56986275
60Type II lissencephaly (HP:0007260)2.56754923
61Gout (HP:0001997)2.56340131
62Confusion (HP:0001289)2.55987557
63Short femoral neck (HP:0100864)2.55105026
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.53713283
65Complement deficiency (HP:0004431)2.52296872
66Abnormality of nucleobase metabolism (HP:0010932)2.51464714
67Hemiplegia (HP:0002301)2.50840366
68Abnormality of the 1st metacarpal (HP:0010009)2.50253000
69Abnormality of the nasal septum (HP:0000419)2.49185092
70Proximal tubulopathy (HP:0000114)2.47848547
71Ketosis (HP:0001946)2.47154785
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47137784
73Abnormality of the common coagulation pathway (HP:0010990)2.46628519
74Hypolipoproteinemia (HP:0010981)2.44898386
75Aplasia/Hypoplasia of the hallux (HP:0008362)2.44545038
76Small hand (HP:0200055)2.43533167
77Persistence of primary teeth (HP:0006335)2.42868698
78Abnormality of fatty-acid metabolism (HP:0004359)2.42095673
79Hypoalphalipoproteinemia (HP:0003233)2.41845112
80Conjunctival hamartoma (HP:0100780)2.41336957
81Adrenal hypoplasia (HP:0000835)2.40964194
82Short phalanx of the thumb (HP:0009660)2.40193751
83Abnormality of midbrain morphology (HP:0002418)2.38537072
84Molar tooth sign on MRI (HP:0002419)2.38537072
85Abnormality of purine metabolism (HP:0004352)2.38306745
86Abnormality of serum amino acid levels (HP:0003112)2.37772828
87Absent thumb (HP:0009777)2.36955579
883-Methylglutaconic aciduria (HP:0003535)2.36599460
89Abnormality of the phalanges of the 5th finger (HP:0004213)2.36482464
90Porencephaly (HP:0002132)2.32041557
91Severe visual impairment (HP:0001141)2.32019268
92Steatorrhea (HP:0002570)2.30489159
93IgG deficiency (HP:0004315)2.30379691
94Decreased circulating renin level (HP:0003351)2.29664634
95Furrowed tongue (HP:0000221)2.28860150
96Visual hallucinations (HP:0002367)2.28447677
97Oligodontia (HP:0000677)2.25797117
98Abnormality of the renal cortex (HP:0011035)2.24860682
99Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24631547
100Chorioretinal atrophy (HP:0000533)2.21885728
101Abnormality of the intrinsic pathway (HP:0010989)2.21870141
102Gaze-evoked nystagmus (HP:0000640)2.20761969
103Agitation (HP:0000713)2.20416115
104Abnormality of urine glucose concentration (HP:0011016)2.20283210
105Glycosuria (HP:0003076)2.20283210
106Oral leukoplakia (HP:0002745)2.19938275
107Synostosis of carpal bones (HP:0005048)2.19299963
108Renal cortical cysts (HP:0000803)2.18925475
109Conical tooth (HP:0000698)2.18839033
110Myocardial infarction (HP:0001658)2.18695798
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17727969
112Short 4th metacarpal (HP:0010044)2.17727969
113Abnormality of the renal medulla (HP:0100957)2.15679152
114Cardiovascular calcification (HP:0011915)2.15423667
115Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.15394276
116Aplasia/Hypoplasia of the tibia (HP:0005772)2.13655344
117Abnormal rod and cone electroretinograms (HP:0008323)2.12742970
118Sclerocornea (HP:0000647)2.11459163
119Alkalosis (HP:0001948)2.11274236
120Metabolic acidosis (HP:0001942)2.10705815
121Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10597117
122Sparse eyelashes (HP:0000653)2.10533944
123Aplasia/hypoplasia of the uterus (HP:0008684)2.10044319
124Short tibia (HP:0005736)2.09309848
125Lethargy (HP:0001254)2.09274270
126Abnormality of chloride homeostasis (HP:0011422)2.09120825
127Hamartoma of the eye (HP:0010568)2.07963426
128Natal tooth (HP:0000695)2.07531791
129Dehydration (HP:0001944)2.07441379
130Abnormality of the pulmonary veins (HP:0011718)2.06762354
131Popliteal pterygium (HP:0009756)2.05368261
132Thyroid-stimulating hormone excess (HP:0002925)2.04958015
133Hepatocellular carcinoma (HP:0001402)2.04586625
134Generalized aminoaciduria (HP:0002909)2.04545546
135Rickets (HP:0002748)2.04414699
136Delayed CNS myelination (HP:0002188)2.02846546
137Palmoplantar hyperkeratosis (HP:0000972)2.01860161
138Attenuation of retinal blood vessels (HP:0007843)2.01597583
139Metabolic alkalosis (HP:0200114)2.01578804
140Diplopia (HP:0000651)2.00898422
141Abnormality of binocular vision (HP:0011514)2.00898422
142Malnutrition (HP:0004395)2.00444568
143Polydipsia (HP:0001959)1.99913179
144Abnormal drinking behavior (HP:0030082)1.99913179
145Abnormality of proline metabolism (HP:0010907)1.99905677
146Hydroxyprolinuria (HP:0003080)1.99905677
147Abnormality of placental membranes (HP:0011409)1.99085607
148Amniotic constriction ring (HP:0009775)1.99085607
149Congenital ichthyosiform erythroderma (HP:0007431)1.98835361
150Alveolar cell carcinoma (HP:0006519)1.98288344
151Hypophosphatemic rickets (HP:0004912)1.98248530
152Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.98027654
153Cystic liver disease (HP:0006706)1.97859745
154Impaired smooth pursuit (HP:0007772)1.97284015
155Hypoplasia of the uterus (HP:0000013)1.97110630
156Mitochondrial inheritance (HP:0001427)1.96825801
157Abnormality of homocysteine metabolism (HP:0010919)1.96424883
158Homocystinuria (HP:0002156)1.96424883
159Hypercholesterolemia (HP:0003124)1.95476811
160Paralysis (HP:0003470)1.95462344
161Stenosis of the external auditory canal (HP:0000402)1.95324962
162Tetany (HP:0001281)1.94745014
163Carpal bone hypoplasia (HP:0001498)1.94332355
164Symphalangism affecting the phalanges of the hand (HP:0009773)1.93207573
165Anomalous pulmonary venous return (HP:0010772)1.93028727
166Hematochezia (HP:0002573)1.91529670
167Hyperactive renin-angiotensin system (HP:0000841)1.91399230
168Hypoglycemic coma (HP:0001325)1.90586622
169Ectropion (HP:0000656)1.90289836
170Ketoacidosis (HP:0001993)1.88793068
171Palmar hyperkeratosis (HP:0010765)1.88142422
172Goiter (HP:0000853)1.87742492
173Spontaneous abortion (HP:0005268)1.87549507
174Morphological abnormality of the middle ear (HP:0008609)1.86862593
175Duplicated collecting system (HP:0000081)1.85946590
176Aplasia cutis congenita (HP:0001057)1.85781315
177Hyperuricemia (HP:0002149)1.85724595
178Increased purine levels (HP:0004368)1.85724595
179Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85643044
180Corneal erosion (HP:0200020)1.84939678
181Abnormality of complement system (HP:0005339)1.84833061
182Enlarged kidneys (HP:0000105)1.84306626
183Severe muscular hypotonia (HP:0006829)1.83188760
184Dicarboxylic aciduria (HP:0003215)1.83070631
185Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83070631
186Concave nail (HP:0001598)1.82974005
187Aplasia/Hypoplasia of the patella (HP:0006498)1.82258279
188Right ventricular cardiomyopathy (HP:0011663)1.81788480
189Thick nail (HP:0001805)1.81533474
190Disproportionate short-trunk short stature (HP:0003521)1.81511638
191Ectopic kidney (HP:0000086)1.81329907
192Abnormality of secondary sexual hair (HP:0009888)1.78459359
193Abnormality of the axillary hair (HP:0100134)1.78459359
194Pancreatitis (HP:0001733)1.77226984
195Neoplasm of the tracheobronchial system (HP:0100552)1.76907324
196Hyperglycemia (HP:0003074)1.75389342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.03738089
2STK38L3.97253775
3LATS13.93933319
4ERBB43.13626539
5MST1R2.94855358
6BMPR22.68817540
7BUB12.41277068
8MAP3K62.38192400
9MAPKAPK32.34999888
10TAOK32.31525707
11MAP3K142.30068400
12PRKD22.21260925
13EPHA22.05197219
14FRK1.96310434
15PBK1.89536958
16BCKDK1.85295041
17CDK81.76297467
18CASK1.76229377
19BMPR1B1.75137271
20ACVR1B1.72297322
21EPHB21.69780512
22FGFR41.59441739
23MAP4K21.57892087
24MUSK1.53219218
25WNK31.51227996
26LATS21.50081617
27MAP3K31.50044250
28TIE11.49269194
29IRAK31.48417182
30MST41.46741001
31SGK21.44341115
32NUAK11.44223983
33PHKG21.42696232
34PHKG11.42696232
35TRPM71.39111447
36NEK91.37324981
37DAPK21.34382022
38MAP3K131.33396476
39PLK41.31967506
40STK31.30628057
41GRK11.30413428
42BRAF1.26505351
43TAF11.25615349
44STK161.23032126
45OXSR11.22933362
46MAPKAPK51.22642464
47GRK61.22216576
48AKT31.20943278
49STK241.19195248
50MAP3K41.17957978
51GRK51.17506332
52NLK1.12688021
53TNIK1.06544954
54EPHA31.06432097
55RPS6KB21.05736883
56PINK11.05151426
57IKBKE1.03145203
58FER1.01136914
59WNK41.00284590
60ABL20.97586884
61PRKCG0.95366594
62SGK2230.95022972
63SGK4940.95022972
64ADRBK10.93379186
65INSRR0.93366777
66FGFR20.91893060
67STK390.90355276
68ZAK0.89819927
69PIK3CG0.89505904
70CSNK1G20.88649370
71MOS0.87352842
72BLK0.86583761
73CSNK1G30.85722282
74EIF2AK20.85512803
75MAP2K60.81211004
76PTK2B0.78434699
77IKBKB0.78348226
78CSNK1G10.76284606
79CDK90.75098410
80ERBB30.74970646
81MAP2K70.73438763
82VRK10.73145577
83TTK0.73090727
84MAP3K120.72549657
85SGK30.72267787
86KIT0.72021752
87PLK20.71352139
88CHUK0.71115059
89RPS6KA50.70407107
90PIK3CA0.69833038
91CDK30.67265880
92RPS6KA60.66989963
93STK100.65525342
94TGFBR20.65153867
95TEC0.64995448
96PAK30.64963028
97WNK10.64958823
98PRKAA20.64789923
99JAK30.64739877
100PRKCH0.61837932
101PRKCI0.61664072
102CSNK1A10.60421498
103PRKACA0.59721878
104MAP2K40.59419829
105CSNK1A1L0.58843058
106FLT30.58250346
107ABL10.58200141
108CAMKK20.57122909
109EPHA40.54427905
110PRPF4B0.53932819
111SIK10.53836808
112MAPK110.53431922
113SIK30.52777465
114ERBB20.52208914
115AURKA0.51313532
116SYK0.51145722
117CAMK2A0.50946678
118YES10.50111813
119VRK20.49197283
120DYRK20.48525574
121LMTK20.47127108
122MKNK20.45464776
123PTK20.44552650
124EEF2K0.44216003
125PRKCQ0.43907663
126MAP2K10.43736705
127MET0.43128197
128TXK0.41404138
129MAPK150.41308712
130IGF1R0.41129702
131MAPK130.40812641
132NEK20.40552665
133PRKAA10.40127049
134SGK10.40047611
135GRK70.39106691
136STK380.38783732
137MAP3K10.38497449
138PRKCA0.37369735
139MAP3K50.36879761
140PRKCZ0.36876241
141ADRBK20.36223555
142PKN10.35857517
143STK110.35757140
144PIM10.35730790
145NTRK30.35275581
146ARAF0.35021575
147DAPK30.34889802
148NME10.34794232
149CAMK10.34629220
150RPS6KA20.34603127
151NTRK20.33710655
152RPS6KL10.33554379
153RPS6KC10.33554379
154TGFBR10.33548701
155HIPK20.33355003
156PRKCE0.33044702
157MELK0.32344910
158MAP2K20.31398926

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.92052102
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.41853340
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16216929
4Histidine metabolism_Homo sapiens_hsa003402.76523315
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.64126882
6Nicotine addiction_Homo sapiens_hsa050332.55442300
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.55010477
8Tryptophan metabolism_Homo sapiens_hsa003802.42262475
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.40981204
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40006502
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37671341
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31620754
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29155581
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28968860
15Peroxisome_Homo sapiens_hsa041462.27688805
16Complement and coagulation cascades_Homo sapiens_hsa046102.27435334
17Fatty acid degradation_Homo sapiens_hsa000712.23469228
18Chemical carcinogenesis_Homo sapiens_hsa052042.19587154
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.18032544
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17209701
21Steroid hormone biosynthesis_Homo sapiens_hsa001402.15976262
22beta-Alanine metabolism_Homo sapiens_hsa004102.10492723
23Phototransduction_Homo sapiens_hsa047442.10475029
24Oxidative phosphorylation_Homo sapiens_hsa001902.10320409
25Arginine biosynthesis_Homo sapiens_hsa002202.08511457
26Retinol metabolism_Homo sapiens_hsa008302.00486498
27Morphine addiction_Homo sapiens_hsa050321.98216733
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96302024
29Propanoate metabolism_Homo sapiens_hsa006401.91816789
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.84532213
31Sulfur metabolism_Homo sapiens_hsa009201.79583711
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75839028
33Butanoate metabolism_Homo sapiens_hsa006501.73552822
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73001252
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72911112
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.71357534
37Homologous recombination_Homo sapiens_hsa034401.68518381
38RNA polymerase_Homo sapiens_hsa030201.68274547
39Parkinsons disease_Homo sapiens_hsa050121.64865010
40Staphylococcus aureus infection_Homo sapiens_hsa051501.63733777
41Fatty acid metabolism_Homo sapiens_hsa012121.59990175
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56498881
43PPAR signaling pathway_Homo sapiens_hsa033201.56073692
44Vitamin B6 metabolism_Homo sapiens_hsa007501.52451838
45Linoleic acid metabolism_Homo sapiens_hsa005911.51512041
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50082872
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49151561
48Steroid biosynthesis_Homo sapiens_hsa001001.48869809
49Systemic lupus erythematosus_Homo sapiens_hsa053221.48739461
50Vitamin digestion and absorption_Homo sapiens_hsa049771.48248526
51Phenylalanine metabolism_Homo sapiens_hsa003601.47435568
52Fatty acid elongation_Homo sapiens_hsa000621.42910054
53Folate biosynthesis_Homo sapiens_hsa007901.34962609
54Nitrogen metabolism_Homo sapiens_hsa009101.34696852
55Caffeine metabolism_Homo sapiens_hsa002321.34406083
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.32085717
57Starch and sucrose metabolism_Homo sapiens_hsa005001.31432091
58Insulin secretion_Homo sapiens_hsa049111.28314213
59Taste transduction_Homo sapiens_hsa047421.28100689
60Alzheimers disease_Homo sapiens_hsa050101.27727906
61Renin secretion_Homo sapiens_hsa049241.27037918
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25904214
63Tyrosine metabolism_Homo sapiens_hsa003501.25168828
64Glutathione metabolism_Homo sapiens_hsa004801.23784868
65Primary immunodeficiency_Homo sapiens_hsa053401.20198440
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17095932
67Glutamatergic synapse_Homo sapiens_hsa047241.16972723
68Bile secretion_Homo sapiens_hsa049761.16261724
69Asthma_Homo sapiens_hsa053101.14066644
70Circadian entrainment_Homo sapiens_hsa047131.13313645
71Arginine and proline metabolism_Homo sapiens_hsa003301.13248214
72Cardiac muscle contraction_Homo sapiens_hsa042601.13040984
73Arachidonic acid metabolism_Homo sapiens_hsa005901.11043628
74GABAergic synapse_Homo sapiens_hsa047271.09922846
75ABC transporters_Homo sapiens_hsa020101.07953653
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07554512
77Serotonergic synapse_Homo sapiens_hsa047261.04220162
78Pyruvate metabolism_Homo sapiens_hsa006201.01481262
79Huntingtons disease_Homo sapiens_hsa050160.99536499
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.95502314
81Cholinergic synapse_Homo sapiens_hsa047250.95131156
82Ribosome_Homo sapiens_hsa030100.94676259
83Calcium signaling pathway_Homo sapiens_hsa040200.93043252
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.91994677
85Olfactory transduction_Homo sapiens_hsa047400.91926448
86Ovarian steroidogenesis_Homo sapiens_hsa049130.88961318
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88542306
88Ether lipid metabolism_Homo sapiens_hsa005650.88100718
89Collecting duct acid secretion_Homo sapiens_hsa049660.87233599
90Gastric acid secretion_Homo sapiens_hsa049710.85158689
91RNA degradation_Homo sapiens_hsa030180.85085781
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84466241
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82413442
94Sulfur relay system_Homo sapiens_hsa041220.81776818
95Melanoma_Homo sapiens_hsa052180.81707835
96Amphetamine addiction_Homo sapiens_hsa050310.80562428
97Selenocompound metabolism_Homo sapiens_hsa004500.79800555
98Alcoholism_Homo sapiens_hsa050340.78260999
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78082235
100Salivary secretion_Homo sapiens_hsa049700.73930855
101Cocaine addiction_Homo sapiens_hsa050300.72080091
102Dopaminergic synapse_Homo sapiens_hsa047280.71618637
103Protein export_Homo sapiens_hsa030600.69196495
104cAMP signaling pathway_Homo sapiens_hsa040240.68281780
105Dorso-ventral axis formation_Homo sapiens_hsa043200.67404491
106Fat digestion and absorption_Homo sapiens_hsa049750.64888835
107Other glycan degradation_Homo sapiens_hsa005110.62179558
108Regulation of autophagy_Homo sapiens_hsa041400.62066750
109Type II diabetes mellitus_Homo sapiens_hsa049300.59933766
110Metabolic pathways_Homo sapiens_hsa011000.59511172
111Sphingolipid metabolism_Homo sapiens_hsa006000.58243244
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55301673
113Oxytocin signaling pathway_Homo sapiens_hsa049210.54712597
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53860635
115Purine metabolism_Homo sapiens_hsa002300.53394243
116Lysine degradation_Homo sapiens_hsa003100.53273163
117Synaptic vesicle cycle_Homo sapiens_hsa047210.51352676
118Hedgehog signaling pathway_Homo sapiens_hsa043400.50906582
119Circadian rhythm_Homo sapiens_hsa047100.50284901
120Carbon metabolism_Homo sapiens_hsa012000.48100200
121Fatty acid biosynthesis_Homo sapiens_hsa000610.46468720
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.46248155
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45007932
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44357327
125Biosynthesis of amino acids_Homo sapiens_hsa012300.44115483
126Graft-versus-host disease_Homo sapiens_hsa053320.43424954
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41219177
128MAPK signaling pathway_Homo sapiens_hsa040100.40015527
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39778379
130Autoimmune thyroid disease_Homo sapiens_hsa053200.39751311
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.39653933
132Allograft rejection_Homo sapiens_hsa053300.39329304
133Mineral absorption_Homo sapiens_hsa049780.38578191
134Glycerolipid metabolism_Homo sapiens_hsa005610.37488531
135Pentose phosphate pathway_Homo sapiens_hsa000300.34787929
136One carbon pool by folate_Homo sapiens_hsa006700.32075958
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29009712
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28414210
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26789449
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25885357
141Hematopoietic cell lineage_Homo sapiens_hsa046400.25542572
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24720211
143Renin-angiotensin system_Homo sapiens_hsa046140.20193161
144Basal cell carcinoma_Homo sapiens_hsa052170.19696338
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19160301
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18424431
147Galactose metabolism_Homo sapiens_hsa000520.17592714
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16423652
149ECM-receptor interaction_Homo sapiens_hsa045120.16174169
150Malaria_Homo sapiens_hsa051440.10762106
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10713750
152Hepatitis C_Homo sapiens_hsa051600.09681162
153Basal transcription factors_Homo sapiens_hsa030220.08486117
154Protein digestion and absorption_Homo sapiens_hsa049740.07200004
155Fanconi anemia pathway_Homo sapiens_hsa034600.03377774
156TGF-beta signaling pathway_Homo sapiens_hsa043500.03126269
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02635874
158NF-kappa B signaling pathway_Homo sapiens_hsa040640.02285567
159Fructose and mannose metabolism_Homo sapiens_hsa000510.02217358

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