SLC25A47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.72325377
2omega-hydroxylase P450 pathway (GO:0097267)9.36679954
3epoxygenase P450 pathway (GO:0019373)9.17153107
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.57778272
5L-phenylalanine catabolic process (GO:0006559)7.57778272
6L-phenylalanine metabolic process (GO:0006558)7.27390762
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27390762
8aromatic amino acid family catabolic process (GO:0009074)6.80645974
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.52360753
10drug metabolic process (GO:0017144)6.24290861
11opsonization (GO:0008228)6.18463154
12tryptophan catabolic process (GO:0006569)6.12727734
13indole-containing compound catabolic process (GO:0042436)6.12727734
14indolalkylamine catabolic process (GO:0046218)6.12727734
15kynurenine metabolic process (GO:0070189)6.03078173
16bile acid biosynthetic process (GO:0006699)5.91875526
17oxidative demethylation (GO:0070989)5.91280707
18glyoxylate metabolic process (GO:0046487)5.77793763
19regulation of plasminogen activation (GO:0010755)5.76828308
20tryptophan metabolic process (GO:0006568)5.76738825
21urea cycle (GO:0000050)5.69488174
22urea metabolic process (GO:0019627)5.69488174
23high-density lipoprotein particle remodeling (GO:0034375)5.67702234
24negative regulation of fibrinolysis (GO:0051918)5.65617827
25alpha-linolenic acid metabolic process (GO:0036109)5.64650652
26ethanol metabolic process (GO:0006067)5.62835033
27regulation of fibrinolysis (GO:0051917)5.44028238
28sulfur amino acid catabolic process (GO:0000098)5.41536419
29protein carboxylation (GO:0018214)5.39736557
30peptidyl-glutamic acid carboxylation (GO:0017187)5.39736557
31regulation of protein activation cascade (GO:2000257)5.28474562
32cysteine metabolic process (GO:0006534)5.27182973
33complement activation, alternative pathway (GO:0006957)5.25777909
34nitrogen cycle metabolic process (GO:0071941)5.23358419
35serine family amino acid catabolic process (GO:0009071)5.14270619
36regulation of humoral immune response (GO:0002920)5.12515255
37bile acid metabolic process (GO:0008206)5.07839555
38disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.02498142
39killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.02498142
40regulation of cholesterol esterification (GO:0010872)5.00305227
41regulation of triglyceride catabolic process (GO:0010896)5.00164174
42reverse cholesterol transport (GO:0043691)4.96903434
43aromatic amino acid family metabolic process (GO:0009072)4.94949766
44regulation of complement activation (GO:0030449)4.90303663
45negative regulation of protein activation cascade (GO:2000258)4.89048667
46protein-lipid complex remodeling (GO:0034368)4.87090270
47macromolecular complex remodeling (GO:0034367)4.87090270
48plasma lipoprotein particle remodeling (GO:0034369)4.87090270
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86275274
50tyrosine metabolic process (GO:0006570)4.81816170
51negative regulation of hemostasis (GO:1900047)4.78533296
52negative regulation of blood coagulation (GO:0030195)4.78533296
53phenylpropanoid metabolic process (GO:0009698)4.74745009
54homocysteine metabolic process (GO:0050667)4.74617816
55triglyceride homeostasis (GO:0070328)4.69915275
56acylglycerol homeostasis (GO:0055090)4.69915275
57phospholipid efflux (GO:0033700)4.68702353
58alpha-amino acid catabolic process (GO:1901606)4.65510481
59negative regulation of cholesterol transport (GO:0032375)4.65332923
60negative regulation of sterol transport (GO:0032372)4.65332923
61amino-acid betaine metabolic process (GO:0006577)4.63478333
62positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.60952591
63coenzyme catabolic process (GO:0009109)4.58861099
64lysine metabolic process (GO:0006553)4.54962561
65lysine catabolic process (GO:0006554)4.54962561
66cellular ketone body metabolic process (GO:0046950)4.48351004
67plasma lipoprotein particle clearance (GO:0034381)4.42655092
68glycine metabolic process (GO:0006544)4.41089616
69imidazole-containing compound metabolic process (GO:0052803)4.34977565
70bile acid and bile salt transport (GO:0015721)4.34600518
71negative regulation of coagulation (GO:0050819)4.34290534
72S-adenosylmethionine metabolic process (GO:0046500)4.34080893
73indolalkylamine metabolic process (GO:0006586)4.32959853
74negative regulation of wound healing (GO:0061045)4.29598917
75cellular amino acid catabolic process (GO:0009063)4.29344466
76cholesterol efflux (GO:0033344)4.28122803
77cellular biogenic amine catabolic process (GO:0042402)4.23682423
78amine catabolic process (GO:0009310)4.23682423
79cellular modified amino acid catabolic process (GO:0042219)4.22237725
80glutamate metabolic process (GO:0006536)4.21990280
81positive regulation of hemostasis (GO:1900048)4.21613040
82positive regulation of blood coagulation (GO:0030194)4.21613040
83cellular glucuronidation (GO:0052695)4.19113076
84serine family amino acid metabolic process (GO:0009069)4.15703825
85benzene-containing compound metabolic process (GO:0042537)4.12827756
86arginine metabolic process (GO:0006525)4.06302642
87alkaloid metabolic process (GO:0009820)4.04469609
88plasma lipoprotein particle assembly (GO:0034377)4.03167270
89fibrinolysis (GO:0042730)4.02704258
90dicarboxylic acid biosynthetic process (GO:0043650)3.99279744
91serine family amino acid biosynthetic process (GO:0009070)3.98569269
92low-density lipoprotein particle remodeling (GO:0034374)3.98566499
93acute inflammatory response (GO:0002526)3.96876418
94aldehyde catabolic process (GO:0046185)3.95649594
95ethanol oxidation (GO:0006069)3.94148682
96cofactor catabolic process (GO:0051187)3.92267568
97positive regulation of lipoprotein lipase activity (GO:0051006)3.91463762
98positive regulation of triglyceride lipase activity (GO:0061365)3.91463762
99negative regulation of complement activation (GO:0045916)3.90448271
100blood coagulation, intrinsic pathway (GO:0007597)3.88721095
101drug catabolic process (GO:0042737)3.88010108
102ketone body metabolic process (GO:1902224)3.87868721
103negative regulation of lipase activity (GO:0060192)3.86197564
104positive regulation of coagulation (GO:0050820)3.85679436
105positive regulation of lipid catabolic process (GO:0050996)3.84334472
106cholesterol homeostasis (GO:0042632)3.77050906
107positive regulation of fatty acid biosynthetic process (GO:0045723)3.76256883
108organic acid catabolic process (GO:0016054)3.75186320
109carboxylic acid catabolic process (GO:0046395)3.75186320
110complement activation, classical pathway (GO:0006958)3.74338499
111flavonoid metabolic process (GO:0009812)3.73191641
112phospholipid homeostasis (GO:0055091)3.72356701
113regulation of bile acid biosynthetic process (GO:0070857)3.71907607
114protein activation cascade (GO:0072376)3.71376995
115sterol homeostasis (GO:0055092)3.70587732
116glucuronate metabolic process (GO:0019585)3.70201465
117uronic acid metabolic process (GO:0006063)3.70201465
118complement activation (GO:0006956)3.70005189
119very-low-density lipoprotein particle assembly (GO:0034379)3.69962298
120plasma lipoprotein particle organization (GO:0071827)3.68216816
121regulation of cholesterol homeostasis (GO:2000188)3.64397664
122acetyl-CoA metabolic process (GO:0006084)3.61547892
123protein-lipid complex assembly (GO:0065005)3.60714410
124cytolysis (GO:0019835)3.60436902
125short-chain fatty acid metabolic process (GO:0046459)3.59935886
126regulation of acute inflammatory response (GO:0002673)3.59662621
127heme transport (GO:0015886)3.58364642
128regulation of apoptotic cell clearance (GO:2000425)3.57037261
129acute-phase response (GO:0006953)3.55270096
130intestinal cholesterol absorption (GO:0030299)3.54421102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.47308693
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.24985084
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.93636611
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.53354874
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.41850403
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14217572
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94941224
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09596374
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01416871
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04398624
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0511818
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98320799
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95820804
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.57980794
15CLOCK_20551151_ChIP-Seq_293T_Human1.52225652
16HTT_18923047_ChIP-ChIP_STHdh_Human1.47221033
17GATA1_22025678_ChIP-Seq_K562_Human1.45643391
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41591293
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.40573064
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.28858352
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24205249
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24163382
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17019765
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12369633
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04034694
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01255122
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94058979
28SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91267856
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91208805
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86054716
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83140577
32AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82919865
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81640802
34RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81108769
35GATA4_25053715_ChIP-Seq_YYC3_Human0.79388351
36BCAT_22108803_ChIP-Seq_LS180_Human0.78944638
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78084974
38IRF8_22096565_ChIP-ChIP_GC-B_Human0.78037428
39SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77536431
40RARA_24833708_ChIP-Seq_LIVER_Mouse0.76790722
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75472764
42SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74823953
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74034294
44SOX2_21211035_ChIP-Seq_LN229_Human0.72971076
45KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72555937
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70917462
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70507929
48ESR2_21235772_ChIP-Seq_MCF-7_Human0.69745894
49HNFA_21074721_ChIP-Seq_CACO-2_Human0.68332192
50SMC4_20622854_ChIP-Seq_HELA_Human0.68119668
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67456269
52CTCF_27219007_Chip-Seq_Bcells_Human0.67386507
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66881514
54RARB_24833708_ChIP-Seq_LIVER_Mouse0.66767865
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65990199
56STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65488704
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65461682
58E2F1_20622854_ChIP-Seq_HELA_Human0.65417036
59RAC3_21632823_ChIP-Seq_H3396_Human0.65024806
60ELF1_20517297_ChIP-Seq_JURKAT_Human0.64934171
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64383014
62ZNF263_19887448_ChIP-Seq_K562_Human0.64326355
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63948287
64PHF8_20622853_ChIP-Seq_HELA_Human0.63887768
65DNAJC2_21179169_ChIP-ChIP_NT2_Human0.63688941
66LXR_22292898_ChIP-Seq_THP-1_Human0.62400149
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60985403
68MYC_19829295_ChIP-Seq_ESCs_Human0.60635959
69SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60631530
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60342206
71SPI1_20517297_ChIP-Seq_HL60_Human0.60122273
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.59485372
73ETV2_25802403_ChIP-Seq_MESCs_Mouse0.59441893
74SA1_27219007_Chip-Seq_Bcells_Human0.59276376
75SRY_22984422_ChIP-ChIP_TESTIS_Rat0.58877585
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.57750933
77TP53_18474530_ChIP-ChIP_U2OS_Human0.56736999
78CTCF_20526341_ChIP-Seq_ESCs_Human0.56585204
79CEBPB_22108803_ChIP-Seq_LS180_Human0.56312846
80NFYA_21822215_ChIP-Seq_K562_Human0.56289774
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55488418
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55488418
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.53670093
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.52585862
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.52515485
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52486032
87CDX2_20551321_ChIP-Seq_CACO-2_Human0.51899195
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51724101
89POU5F1_16518401_ChIP-PET_MESCs_Mouse0.51684113
90ESET_19884257_ChIP-Seq_ESCs_Mouse0.51236467
91AR_20517297_ChIP-Seq_VCAP_Human0.50480321
92FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49956252
93FOXA1_25552417_ChIP-Seq_VCAP_Human0.49462551
94EGR1_19032775_ChIP-ChIP_M12_Human0.48582424
95MYC_19915707_ChIP-ChIP_AK7_Human0.48104269
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47662133
97BCL6_27268052_Chip-Seq_Bcells_Human0.45672165
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.45615698
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.45478687
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45457487
101CBX2_22325352_ChIP-Seq_293T-Rex_Human0.45167168
102PHF8_20622854_ChIP-Seq_HELA_Human0.44844041
103NFE2_27457419_Chip-Seq_LIVER_Mouse0.44757105
104P53_21459846_ChIP-Seq_SAOS-2_Human0.44619617
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44158291
106PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44056646
107IRF1_19129219_ChIP-ChIP_H3396_Human0.43163637
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.43146431
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42396024
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.41588477
111STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41562131
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.41459272
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.41398190
114GATA6_25053715_ChIP-Seq_YYC3_Human0.41388080
115MYC_27129775_Chip-Seq_CORNEA_Mouse0.40780244
116GATA1_19941826_ChIP-Seq_K562_Human0.40434596
117TAF2_19829295_ChIP-Seq_ESCs_Human0.39542696
118STAT1_17558387_ChIP-Seq_HELA_Human0.39463750
119SPI1_26923725_Chip-Seq_HPCs_Mouse0.39302491
120CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38576615
121CBP_21632823_ChIP-Seq_H3396_Human0.38489540
122GATA2_19941826_ChIP-Seq_K562_Human0.38148878
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.37221519
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37172173
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36485845
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.36166719
127BCOR_27268052_Chip-Seq_Bcells_Human0.35775353
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.34842857
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34826004
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.34545332
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.34528768
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.33995445
133SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33992796
134ERG_20517297_ChIP-Seq_VCAP_Human0.33640490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.31496211
2MP0005360_urolithiasis7.46757649
3MP0005085_abnormal_gallbladder_physiolo6.47146170
4MP0005365_abnormal_bile_salt6.18606112
5MP0008875_abnormal_xenobiotic_pharmacok5.19763123
6MP0003806_abnormal_nucleotide_metabolis4.17785390
7MP0003252_abnormal_bile_duct3.93370918
8MP0010329_abnormal_lipoprotein_level3.61289789
9MP0009840_abnormal_foam_cell3.38196306
10MP0005083_abnormal_biliary_tract3.04871803
11MP0003195_calcinosis2.79510854
12MP0005332_abnormal_amino_acid2.76051332
13MP0001666_abnormal_nutrient_absorption2.56454684
14MP0003191_abnormal_cellular_cholesterol2.40544065
15MP0000609_abnormal_liver_physiology2.19987940
16MP0004019_abnormal_vitamin_homeostasis2.11241293
17MP0002118_abnormal_lipid_homeostasis2.11061566
18MP0002138_abnormal_hepatobiliary_system1.95642911
19MP0003868_abnormal_feces_composition1.93496692
20MP0005319_abnormal_enzyme/_coenzyme1.86087691
21MP0003011_delayed_dark_adaptation1.66621913
22MP0001764_abnormal_homeostasis1.64330018
23MP0005584_abnormal_enzyme/coenzyme_acti1.55686858
24MP0005451_abnormal_body_composition1.53653834
25MP0009697_abnormal_copulation1.52077879
26MP0003656_abnormal_erythrocyte_physiolo1.28298660
27MP0003705_abnormal_hypodermis_morpholog1.27075903
28MP0003186_abnormal_redox_activity1.26114605
29MP0002254_reproductive_system_inflammat1.22970244
30MP0009643_abnormal_urine_homeostasis1.20579828
31MP0000598_abnormal_liver_morphology1.20432728
32MP0005647_abnormal_sex_gland1.11374380
33MP0000604_amyloidosis1.06617141
34MP0002282_abnormal_trachea_morphology1.05546223
35MP0009764_decreased_sensitivity_to1.04410455
36MP0009763_increased_sensitivity_to1.02154192
37MP0010368_abnormal_lymphatic_system0.97092217
38MP0005670_abnormal_white_adipose0.94289679
39MP0005636_abnormal_mineral_homeostasis0.89012602
40MP0008469_abnormal_protein_level0.87818076
41MP0002249_abnormal_larynx_morphology0.86710062
42MP0009642_abnormal_blood_homeostasis0.86188196
43MP0006036_abnormal_mitochondrial_physio0.84348963
44MP0005376_homeostasis/metabolism_phenot0.82420927
45MP0001915_intracranial_hemorrhage0.81453553
46MP0009765_abnormal_xenobiotic_induced0.78298957
47MP0005408_hypopigmentation0.78133933
48MP0002078_abnormal_glucose_homeostasis0.77622586
49MP0003879_abnormal_hair_cell0.75404455
50MP0002876_abnormal_thyroid_physiology0.73751097
51MP0002971_abnormal_brown_adipose0.72061143
52MP0005266_abnormal_metabolism0.70888400
53MP0005084_abnormal_gallbladder_morpholo0.68171649
54MP0005334_abnormal_fat_pad0.67795241
55MP0006035_abnormal_mitochondrial_morpho0.66820552
56MP0003690_abnormal_glial_cell0.65163652
57MP0004130_abnormal_muscle_cell0.65001043
58MP0005220_abnormal_exocrine_pancreas0.64668769
59MP0009785_altered_susceptibility_to0.64016570
60MP0005535_abnormal_body_temperature0.63046350
61MP0009053_abnormal_anal_canal0.62919236
62MP0005023_abnormal_wound_healing0.62249255
63MP0005187_abnormal_penis_morphology0.61631801
64MP0000639_abnormal_adrenal_gland0.61611146
65MP0001661_extended_life_span0.61403773
66MP0003329_amyloid_beta_deposits0.58307972
67MP0001756_abnormal_urination0.57919939
68MP0005448_abnormal_energy_balance0.54669971
69MP0005464_abnormal_platelet_physiology0.51131483
70MP0005395_other_phenotype0.46604816
71MP0008873_increased_physiological_sensi0.46571289
72MP0002822_catalepsy0.45888257
73MP0008874_decreased_physiological_sensi0.45692235
74MP0000566_synostosis0.45451723
75MP0003638_abnormal_response/metabolism_0.45427932
76MP0005248_abnormal_Harderian_gland0.44678381
77MP0000467_abnormal_esophagus_morphology0.44640173
78MP0002136_abnormal_kidney_physiology0.43670204
79MP0006292_abnormal_olfactory_placode0.43512551
80MP0002928_abnormal_bile_duct0.43092890
81MP0003718_maternal_effect0.42956604
82MP0003436_decreased_susceptibility_to0.42831696
83MP0005666_abnormal_adipose_tissue0.41849412
84MP0001545_abnormal_hematopoietic_system0.41230210
85MP0005397_hematopoietic_system_phenotyp0.41230210
86MP0008872_abnormal_physiological_respon0.40027378
87MP0003075_altered_response_to0.39906104
88MP0004782_abnormal_surfactant_physiolog0.39723176
89MP0003953_abnormal_hormone_level0.38855001
90MP0006082_CNS_inflammation0.38074592
91MP0004381_abnormal_hair_follicle0.37549990
92MP0009115_abnormal_fat_cell0.36455221
93MP0002970_abnormal_white_adipose0.36331950
94MP0002837_dystrophic_cardiac_calcinosis0.36294191
95MP0003724_increased_susceptibility_to0.36185281
96MP0009672_abnormal_birth_weight0.35889989
97MP0004883_abnormal_blood_vessel0.35871887
98MP0001243_abnormal_dermal_layer0.34672220
99MP0004264_abnormal_extraembryonic_tissu0.34416248
100MP0005166_decreased_susceptibility_to0.34368619
101MP0002332_abnormal_exercise_endurance0.34239893
102MP0001986_abnormal_taste_sensitivity0.33969771
103MP0000249_abnormal_blood_vessel0.33264825
104MP0005058_abnormal_lysosome_morphology0.31477154
105MP0001853_heart_inflammation0.30778551
106MP0000579_abnormal_nail_morphology0.30747024
107MP0002796_impaired_skin_barrier0.30674334
108MP0000230_abnormal_systemic_arterial0.29319027
109MP0002168_other_aberrant_phenotype0.28234489
110MP0009384_cardiac_valve_regurgitation0.27568337
111MP0002132_abnormal_respiratory_system0.27362744
112MP0001845_abnormal_inflammatory_respons0.26988786
113MP0001881_abnormal_mammary_gland0.26804826
114MP0005164_abnormal_response_to0.25752399
115MP0001851_eye_inflammation0.25557754
116MP0002090_abnormal_vision0.22375906
117MP0002128_abnormal_blood_circulation0.22004451
118MP0000678_abnormal_parathyroid_gland0.19869394
119MP0005377_hearing/vestibular/ear_phenot0.19506288
120MP0003878_abnormal_ear_physiology0.19506288

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.46966171
2Deep venous thrombosis (HP:0002625)7.44203445
3Intrahepatic cholestasis (HP:0001406)7.20504006
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75944458
5Prolonged partial thromboplastin time (HP:0003645)6.54031429
6Hypobetalipoproteinemia (HP:0003563)6.45379301
7Xanthomatosis (HP:0000991)6.42099837
8Hyperlipoproteinemia (HP:0010980)5.73839062
9Complement deficiency (HP:0004431)5.24823933
10Hypolipoproteinemia (HP:0010981)4.87746299
11Joint hemorrhage (HP:0005261)4.82226173
12Hyperammonemia (HP:0001987)4.64670523
13Epidermoid cyst (HP:0200040)4.52791330
14Abnormality of the common coagulation pathway (HP:0010990)4.47770345
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45925940
16Abnormality of methionine metabolism (HP:0010901)4.41568146
17Hypoalphalipoproteinemia (HP:0003233)4.37427464
18Hyperglycinemia (HP:0002154)4.31308932
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.29159569
20Ketosis (HP:0001946)4.28450342
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20150574
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08244579
23Nephritis (HP:0000123)4.05530329
24Fat malabsorption (HP:0002630)4.00460043
25Abnormality of pyrimidine metabolism (HP:0004353)3.91835349
26Hyperglycinuria (HP:0003108)3.89011651
27Abnormality of the intrinsic pathway (HP:0010989)3.88800174
28Abnormality of glycine metabolism (HP:0010895)3.85844023
29Abnormality of serine family amino acid metabolism (HP:0010894)3.85844023
30Abnormality of complement system (HP:0005339)3.84757507
31Hypoglycemic coma (HP:0001325)3.78775724
32Hypercholesterolemia (HP:0003124)3.65892798
33Conjugated hyperbilirubinemia (HP:0002908)3.57735318
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37239539
35Hyperbilirubinemia (HP:0002904)3.35711956
36Abnormality of fatty-acid metabolism (HP:0004359)3.32018425
37Hypochromic microcytic anemia (HP:0004840)3.30768649
38Spontaneous abortion (HP:0005268)3.11461593
39Abnormality of nucleobase metabolism (HP:0010932)3.10992097
40Delayed CNS myelination (HP:0002188)3.05219959
41Hepatocellular carcinoma (HP:0001402)3.03105438
42Abnormality of serum amino acid levels (HP:0003112)3.02600375
43Steatorrhea (HP:0002570)3.01213313
44Ketoacidosis (HP:0001993)2.98028894
45Myocardial infarction (HP:0001658)2.91928363
46Skin nodule (HP:0200036)2.91040760
47Metabolic acidosis (HP:0001942)2.79747550
48Neonatal hypoglycemia (HP:0001998)2.77465261
49Abnormality of purine metabolism (HP:0004352)2.70570471
50Systemic lupus erythematosus (HP:0002725)2.65383951
51Gout (HP:0001997)2.63629159
52Purpura (HP:0000979)2.60792193
53Lethargy (HP:0001254)2.59342024
54Dicarboxylic aciduria (HP:0003215)2.57678604
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57678604
56Vascular calcification (HP:0004934)2.52822270
57Abnormal gallbladder morphology (HP:0012437)2.49107112
58Spastic diplegia (HP:0001264)2.48443501
59Fair hair (HP:0002286)2.47044395
60Cholecystitis (HP:0001082)2.45165881
61Abnormal gallbladder physiology (HP:0012438)2.45165881
62Acanthocytosis (HP:0001927)2.45023979
63Cholelithiasis (HP:0001081)2.44991655
64Amyloidosis (HP:0011034)2.44810930
65Irritability (HP:0000737)2.40261537
66Malnutrition (HP:0004395)2.39927013
67Glomerulonephritis (HP:0000099)2.39364839
68Hypoglycemic seizures (HP:0002173)2.39158485
69Cerebral edema (HP:0002181)2.37141753
70Mitral stenosis (HP:0001718)2.36409500
71Pulmonary embolism (HP:0002204)2.35891064
72Neonatal onset (HP:0003623)2.30910467
73Gingival bleeding (HP:0000225)2.30045769
74Osteomalacia (HP:0002749)2.26199882
75Recurrent gram-negative bacterial infections (HP:0005420)2.24902588
76Cardiovascular calcification (HP:0011915)2.23483592
77Enlarged kidneys (HP:0000105)2.18661009
78Menorrhagia (HP:0000132)2.17055452
79Brushfield spots (HP:0001088)2.16174356
80Hyperinsulinemic hypoglycemia (HP:0000825)2.15462872
81Esophageal varix (HP:0002040)2.15267820
82Pancreatitis (HP:0001733)2.13566873
83Thrombophlebitis (HP:0004418)2.09727079
84Late onset (HP:0003584)2.09168402
85Vomiting (HP:0002013)2.08670613
86Sensorimotor neuropathy (HP:0007141)2.06913034
87Abnormal cartilage morphology (HP:0002763)2.03653953
88Joint swelling (HP:0001386)2.03258409
89Abnormality of the gallbladder (HP:0005264)2.01351674
90Hemorrhage of the eye (HP:0011885)1.99690209
91Poikilocytosis (HP:0004447)1.98169328
92Opisthotonus (HP:0002179)1.97448070
93Generalized aminoaciduria (HP:0002909)1.96965753
94Abnormality of iron homeostasis (HP:0011031)1.95790705
95Rickets (HP:0002748)1.94421355
96Elevated alkaline phosphatase (HP:0003155)1.94262887
97Abnormality of transition element cation homeostasis (HP:0011030)1.90898857
98Increased serum ferritin (HP:0003281)1.88478356
99Status epilepticus (HP:0002133)1.88160470
100Epistaxis (HP:0000421)1.87589064
101Gangrene (HP:0100758)1.82584250
102Hyperphosphaturia (HP:0003109)1.82448729
103Abnormal enzyme/coenzyme activity (HP:0012379)1.81242568
104Hypophosphatemic rickets (HP:0004912)1.80987873
105Elevated hepatic transaminases (HP:0002910)1.80726713
106Abnormality of alkaline phosphatase activity (HP:0004379)1.80180115
107Renal cortical cysts (HP:0000803)1.77877977
108Hydroxyprolinuria (HP:0003080)1.76914577
109Abnormality of proline metabolism (HP:0010907)1.76914577
110Alkalosis (HP:0001948)1.75486136
111Increased purine levels (HP:0004368)1.75293341
112Hyperuricemia (HP:0002149)1.75293341
113Reticulocytosis (HP:0001923)1.74672347
114Abnormality of the Achilles tendon (HP:0005109)1.74210750
115Reduced antithrombin III activity (HP:0001976)1.72649501
116Atrioventricular block (HP:0001678)1.72399901
117Generalized hypopigmentation of hair (HP:0011358)1.70717702
118Bifid scrotum (HP:0000048)1.67982328
119Abnormal delivery (HP:0001787)1.64178737
120Cerebral palsy (HP:0100021)1.62740600
121Arthropathy (HP:0003040)1.62191115
122Abnormality of urine glucose concentration (HP:0011016)1.56058842
123Glycosuria (HP:0003076)1.56058842
124Increased mean platelet volume (HP:0011877)1.55113498
125Abnormality of vitamin metabolism (HP:0100508)1.54291786
126Increased serum pyruvate (HP:0003542)1.53719506
127Blue irides (HP:0000635)1.53080564
128Abnormal urine phosphate concentration (HP:0012599)1.49547037
129Abnormal biliary tract physiology (HP:0012439)1.49153994
130Bile duct proliferation (HP:0001408)1.49153994
131Abnormal platelet function (HP:0011869)1.45933565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.06020348
2ERN15.13759847
3FGFR44.41226504
4SIK14.36208443
5TAOK32.89997692
6INSRR2.79174302
7ERBB42.78927909
8MAP2K42.50299439
9PKN22.24626040
10NTRK32.18393644
11PIK3CA1.97799527
12MST1R1.93990412
13FLT31.92570559
14MAPK111.82951147
15TRIB31.80216615
16GRK61.77836893
17TYK21.65563145
18LATS11.57309300
19PIK3CG1.55462080
20ABL21.46506856
21PTK61.37889869
22DAPK21.35755017
23MAP3K71.26975740
24TNK21.25903085
25MAP3K101.23689606
26KDR1.22586463
27NEK91.21484842
28FGFR21.21240822
29PRPF4B1.20653892
30JAK21.19632903
31PINK11.11265997
32PRKAA21.07300516
33BLK1.07085965
34ERBB21.06556881
35FRK1.05691015
36MAP2K31.05162573
37NLK1.04907486
38MAPK41.04509040
39TBK10.98109095
40CSF1R0.96726704
41TGFBR20.95831606
42GRK10.94910918
43MAPK70.94031051
44MAPK120.91829676
45JAK10.91596028
46FER0.90020796
47PRKCZ0.86797469
48CSK0.84967708
49MAP3K30.83570110
50MAP3K140.82897076
51PRKG10.82319158
52MAP2K60.81319759
53EPHB10.81234764
54MET0.80990799
55STK38L0.80175914
56MAPK150.77674927
57CDK60.77431568
58PRKACA0.77397582
59PRKACG0.77289012
60MAP3K110.73665842
61PDK20.73420098
62DYRK1B0.72235024
63MAP3K20.72050977
64CAMKK20.71749812
65EPHA30.71701147
66ZAP700.70124533
67FGFR30.69468469
68GSK3A0.68654229
69TIE10.67331922
70CAMK2G0.64410072
71PRKAA10.63366197
72RIPK10.60876506
73PTK20.60051416
74CAMK1D0.56724285
75SGK30.54701838
76CAMK40.54594339
77IRAK30.53569910
78CSNK1E0.52785206
79TAOK20.50496295
80SGK4940.49750065
81RPS6KA30.49543163
82GRK50.48799722
83MAP4K10.48414965
84CDK40.47952990
85IGF1R0.47617138
86CAMKK10.47260959
87PRKCQ0.47112137
88CSNK1D0.46972823
89PDPK10.46411104
90PRKCB0.45304878
91IKBKE0.44845687
92MAP3K50.44737360
93MTOR0.42220229
94SRC0.41901550
95SGK10.40951542
96PRKCG0.40947006
97EPHA40.39896803
98CDK120.38955159
99CSNK1G10.38712909
100ICK0.38671365
101LATS20.37654999
102SMG10.37599698
103EPHA20.37209055
104PDGFRA0.37110960
105CSNK2A10.36641751
106WNK40.35753611
107MAP2K10.34890719
108RET0.34888196
109EGFR0.33866020
110PKN10.33795731
111MAP3K60.32965651
112SGK20.32416852
113PDK10.32026192
114ADRBK20.29471657
115CSNK2A20.29032410
116MAP3K130.28769162
117MYLK0.28058041
118KSR20.27571290
119AKT30.24748596
120BMX0.23626012
121PRKCA0.23067257
122MAP3K10.20540036
123ABL10.20472137
124MAP2K20.19629106
125ITK0.19380692
126MAPK30.18904409
127PRKACB0.18562961
128IRAK20.18332585
129CSNK1G20.18152693
130SGK2230.18105818

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.51944241
2Nitrogen metabolism_Homo sapiens_hsa009103.54721536
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43635809
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34416362
5Arginine biosynthesis_Homo sapiens_hsa002203.09514871
6Complement and coagulation cascades_Homo sapiens_hsa046102.79050287
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74707182
8Tryptophan metabolism_Homo sapiens_hsa003802.68454579
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60455213
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55934809
11Fatty acid degradation_Homo sapiens_hsa000712.49077786
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38009227
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29869650
14Butanoate metabolism_Homo sapiens_hsa006502.12437077
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11600667
16Peroxisome_Homo sapiens_hsa041462.08318031
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97180852
18Chemical carcinogenesis_Homo sapiens_hsa052041.97110227
19PPAR signaling pathway_Homo sapiens_hsa033201.91431968
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.89968110
21Histidine metabolism_Homo sapiens_hsa003401.88692540
22Propanoate metabolism_Homo sapiens_hsa006401.87451715
23Fatty acid metabolism_Homo sapiens_hsa012121.79995298
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76864669
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76318524
26Staphylococcus aureus infection_Homo sapiens_hsa051501.74152081
27beta-Alanine metabolism_Homo sapiens_hsa004101.69604057
28Retinol metabolism_Homo sapiens_hsa008301.68845235
29Caffeine metabolism_Homo sapiens_hsa002321.67234565
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65755399
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59701253
32Selenocompound metabolism_Homo sapiens_hsa004501.58733657
33Phenylalanine metabolism_Homo sapiens_hsa003601.55856997
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52272572
35Bile secretion_Homo sapiens_hsa049761.49674242
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49581403
37Tyrosine metabolism_Homo sapiens_hsa003501.42706076
38Pyruvate metabolism_Homo sapiens_hsa006201.35284801
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.35266847
40Fatty acid elongation_Homo sapiens_hsa000621.32737956
41Starch and sucrose metabolism_Homo sapiens_hsa005001.28720975
42Sulfur metabolism_Homo sapiens_hsa009201.27718443
43Folate biosynthesis_Homo sapiens_hsa007901.24417101
44Biosynthesis of amino acids_Homo sapiens_hsa012301.22811577
45ABC transporters_Homo sapiens_hsa020101.19591409
46Fat digestion and absorption_Homo sapiens_hsa049751.16902571
47Steroid biosynthesis_Homo sapiens_hsa001001.14078559
48Carbon metabolism_Homo sapiens_hsa012001.13086261
49Vitamin B6 metabolism_Homo sapiens_hsa007501.06734110
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00518140
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.98853098
52Sulfur relay system_Homo sapiens_hsa041220.97896769
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.96449470
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96301355
55Arginine and proline metabolism_Homo sapiens_hsa003300.96093872
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87319737
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84117328
58Vitamin digestion and absorption_Homo sapiens_hsa049770.83989892
59Lysine degradation_Homo sapiens_hsa003100.81392817
60One carbon pool by folate_Homo sapiens_hsa006700.76242516
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73168917
62Glycerolipid metabolism_Homo sapiens_hsa005610.68197610
63Glutathione metabolism_Homo sapiens_hsa004800.63512906
64Pentose phosphate pathway_Homo sapiens_hsa000300.60384758
65Fatty acid biosynthesis_Homo sapiens_hsa000610.49542063
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46498799
67Metabolic pathways_Homo sapiens_hsa011000.46274997
68Pertussis_Homo sapiens_hsa051330.46090525
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36974786
70Fructose and mannose metabolism_Homo sapiens_hsa000510.33803317
71Prion diseases_Homo sapiens_hsa050200.33730261
72Galactose metabolism_Homo sapiens_hsa000520.32647382
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31568617
74Linoleic acid metabolism_Homo sapiens_hsa005910.26861528
75Insulin resistance_Homo sapiens_hsa049310.24694824
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.24248611
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.18473455
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15721789
79Amoebiasis_Homo sapiens_hsa051460.11854013
80Glucagon signaling pathway_Homo sapiens_hsa049220.10568168
81Mineral absorption_Homo sapiens_hsa049780.08696593
82AMPK signaling pathway_Homo sapiens_hsa041520.04579154
83Other glycan degradation_Homo sapiens_hsa005110.04257469
84FoxO signaling pathway_Homo sapiens_hsa04068-0.2787956
85N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2745330
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.2675784
87Bladder cancer_Homo sapiens_hsa05219-0.2414064
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2403887
89Ether lipid metabolism_Homo sapiens_hsa00565-0.2351388
90Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2328242
91Sphingolipid metabolism_Homo sapiens_hsa00600-0.2326528
92Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2287803
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2158580
94Circadian rhythm_Homo sapiens_hsa04710-0.2084553
95Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2054389
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1937357
97Renin-angiotensin system_Homo sapiens_hsa04614-0.1913349
98Hepatitis C_Homo sapiens_hsa05160-0.1747076
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1674791
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1404965
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1335819
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1283402
103Regulation of autophagy_Homo sapiens_hsa04140-0.1264403
104African trypanosomiasis_Homo sapiens_hsa05143-0.1203402
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1036244
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1012029
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0681437
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0541244
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0522980
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0400298
111Serotonergic synapse_Homo sapiens_hsa04726-0.0396356

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