SLC25A42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.35414200
2L-phenylalanine catabolic process (GO:0006559)6.35414200
3L-phenylalanine metabolic process (GO:0006558)6.04874600
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.04874600
5aromatic amino acid family catabolic process (GO:0009074)5.80633021
6indole-containing compound catabolic process (GO:0042436)5.39031521
7indolalkylamine catabolic process (GO:0046218)5.39031521
8tryptophan catabolic process (GO:0006569)5.39031521
9kynurenine metabolic process (GO:0070189)5.22185433
10glyoxylate metabolic process (GO:0046487)5.06565620
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.05840199
12tryptophan metabolic process (GO:0006568)5.03063047
13lysine catabolic process (GO:0006554)4.97987912
14lysine metabolic process (GO:0006553)4.97987912
15bile acid biosynthetic process (GO:0006699)4.90060305
16alpha-linolenic acid metabolic process (GO:0036109)4.68170977
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.67896255
18regulation of isotype switching to IgG isotypes (GO:0048302)4.67830161
19heme transport (GO:0015886)4.55252329
20epoxygenase P450 pathway (GO:0019373)4.51765081
21regulation of triglyceride catabolic process (GO:0010896)4.51051590
22amino-acid betaine metabolic process (GO:0006577)4.49660102
23short-chain fatty acid metabolic process (GO:0046459)4.38555474
24cysteine metabolic process (GO:0006534)4.36913242
25urea metabolic process (GO:0019627)4.34106963
26urea cycle (GO:0000050)4.34106963
27cellular ketone body metabolic process (GO:0046950)4.32840488
28sulfur amino acid catabolic process (GO:0000098)4.29996956
29serine family amino acid catabolic process (GO:0009071)4.29739105
30high-density lipoprotein particle remodeling (GO:0034375)4.29625872
31fatty acid beta-oxidation (GO:0006635)4.27343304
32bile acid metabolic process (GO:0008206)4.18596693
33alpha-amino acid catabolic process (GO:1901606)4.17503659
34aromatic amino acid family metabolic process (GO:0009072)4.17486973
35peptidyl-glutamic acid carboxylation (GO:0017187)4.16909434
36protein carboxylation (GO:0018214)4.16909434
37regulation of fibrinolysis (GO:0051917)4.14259276
38acylglycerol homeostasis (GO:0055090)4.12380030
39triglyceride homeostasis (GO:0070328)4.12380030
40complement activation, alternative pathway (GO:0006957)4.08615616
41omega-hydroxylase P450 pathway (GO:0097267)4.06494299
42coenzyme catabolic process (GO:0009109)4.05872640
43fatty acid oxidation (GO:0019395)4.03988480
44homocysteine metabolic process (GO:0050667)4.03704485
45acetyl-CoA metabolic process (GO:0006084)4.03348036
46nitrogen cycle metabolic process (GO:0071941)4.01849165
47oxidative demethylation (GO:0070989)4.01775339
48negative regulation of fibrinolysis (GO:0051918)3.98830378
49fatty acid transmembrane transport (GO:1902001)3.98346179
50regulation of protein activation cascade (GO:2000257)3.97745661
51lipid oxidation (GO:0034440)3.96939432
52fatty acid catabolic process (GO:0009062)3.96071752
53tyrosine metabolic process (GO:0006570)3.92419904
54cellular amino acid catabolic process (GO:0009063)3.90111348
55aspartate family amino acid catabolic process (GO:0009068)3.89409647
56carnitine shuttle (GO:0006853)3.87385150
57monocarboxylic acid catabolic process (GO:0072329)3.87276991
58amine catabolic process (GO:0009310)3.83449243
59cellular biogenic amine catabolic process (GO:0042402)3.83449243
60indolalkylamine metabolic process (GO:0006586)3.82864540
612-oxoglutarate metabolic process (GO:0006103)3.79504732
62glutamate metabolic process (GO:0006536)3.78476985
63carnitine metabolic process (GO:0009437)3.77206199
64dicarboxylic acid biosynthetic process (GO:0043650)3.76607329
65creatine metabolic process (GO:0006600)3.74916828
66reverse cholesterol transport (GO:0043691)3.74390874
67drug catabolic process (GO:0042737)3.71835292
68carboxylic acid catabolic process (GO:0046395)3.70984200
69organic acid catabolic process (GO:0016054)3.70984200
70ketone body metabolic process (GO:1902224)3.70839113
71regulation of complement activation (GO:0030449)3.70082284
72negative regulation of lipase activity (GO:0060192)3.69888849
73regulation of cholesterol esterification (GO:0010872)3.68261734
74positive regulation of fatty acid beta-oxidation (GO:0032000)3.66897425
75cellular modified amino acid catabolic process (GO:0042219)3.66642639
76protein-lipid complex remodeling (GO:0034368)3.66041727
77macromolecular complex remodeling (GO:0034367)3.66041727
78plasma lipoprotein particle remodeling (GO:0034369)3.66041727
79iron coordination entity transport (GO:1901678)3.63592644
80biotin metabolic process (GO:0006768)3.62511660
81branched-chain amino acid catabolic process (GO:0009083)3.60854228
82regulation of bile acid biosynthetic process (GO:0070857)3.57395086
83ethanol oxidation (GO:0006069)3.57086836
84drug transmembrane transport (GO:0006855)3.56070911
85regulation of sequestering of triglyceride (GO:0010889)3.56061558
86phospholipid efflux (GO:0033700)3.55476986
87S-adenosylmethionine metabolic process (GO:0046500)3.52768447
88benzene-containing compound metabolic process (GO:0042537)3.52595132
89positive regulation of lipid catabolic process (GO:0050996)3.51199716
90phospholipid homeostasis (GO:0055091)3.48551418
91plasma lipoprotein particle clearance (GO:0034381)3.48137497
92cellular glucuronidation (GO:0052695)3.48003792
93bile acid and bile salt transport (GO:0015721)3.46362600
94oxaloacetate metabolic process (GO:0006107)3.41783942
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.40930844
96imidazole-containing compound metabolic process (GO:0052803)3.40114596
97exogenous drug catabolic process (GO:0042738)3.39914422
98glycine metabolic process (GO:0006544)3.38888918
99negative regulation of sterol transport (GO:0032372)3.38254932
100negative regulation of cholesterol transport (GO:0032375)3.38254932
101positive regulation of fatty acid oxidation (GO:0046321)3.37102703
102valine metabolic process (GO:0006573)3.36271925
103branched-chain amino acid metabolic process (GO:0009081)3.35989830
104positive thymic T cell selection (GO:0045059)3.28775945
105negative regulation of type 2 immune response (GO:0002829)3.28211441
106alkaloid metabolic process (GO:0009820)3.26380145
107regulation of lipoprotein particle clearance (GO:0010984)3.25435888
108cholesterol efflux (GO:0033344)3.23479038
109regulation of gamma-delta T cell differentiation (GO:0045586)3.22680702
110regulation of activation of Janus kinase activity (GO:0010533)3.21881182
111drug metabolic process (GO:0017144)3.21578198
112urate metabolic process (GO:0046415)3.20892501
113glucuronate metabolic process (GO:0019585)3.18634954
114uronic acid metabolic process (GO:0006063)3.18634954
115regulation of cholesterol metabolic process (GO:0090181)3.17983888
116flavonoid metabolic process (GO:0009812)3.17096058
117arginine metabolic process (GO:0006525)3.15551287
118cofactor catabolic process (GO:0051187)3.14282312
119regulation of phospholipid biosynthetic process (GO:0071071)3.00254227
120positive T cell selection (GO:0043368)2.95831600
121positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89326189
122regulation of B cell receptor signaling pathway (GO:0050855)2.88532104
123positive regulation of B cell differentiation (GO:0045579)2.82714145
124positive regulation of T-helper 1 type immune response (GO:0002827)2.80760296
125regulation of skeletal muscle contraction (GO:0014819)2.78330379
126negative regulation of telomerase activity (GO:0051974)2.78238851
127phosphatidylcholine acyl-chain remodeling (GO:0036151)2.75795954
128blood coagulation, intrinsic pathway (GO:0007597)2.70579563
129phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.70138358
130cytolysis (GO:0019835)2.69844787
131disruption of cells of other organism (GO:0044364)2.66377449
132killing of cells of other organism (GO:0031640)2.66377449
133piRNA metabolic process (GO:0034587)2.63852465
134regulation of gamma-delta T cell activation (GO:0046643)2.63030816
135cytidine deamination (GO:0009972)2.57000509
136cytidine metabolic process (GO:0046087)2.57000509
137cytidine catabolic process (GO:0006216)2.57000509
138positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55071638
139killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.53872346
140disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.53872346
141cellular response to interleukin-15 (GO:0071350)2.52804663
142detection of light stimulus involved in sensory perception (GO:0050962)2.51900717
143detection of light stimulus involved in visual perception (GO:0050908)2.51900717
144regulation of humoral immune response (GO:0002920)2.51524427
145drug transport (GO:0015893)2.51034818
146oxygen transport (GO:0015671)2.50658337
147positive regulation of gamma-delta T cell activation (GO:0046645)2.50014552
148thymic T cell selection (GO:0045061)2.48991117
149response to interleukin-15 (GO:0070672)2.48957467
150serine family amino acid metabolic process (GO:0009069)2.48573590
151antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47270522
152response to mercury ion (GO:0046689)2.45583630
153regulation of interferon-beta biosynthetic process (GO:0045357)2.44782423
154DNA deamination (GO:0045006)2.44772692
155muscle filament sliding (GO:0030049)2.44364684
156actin-myosin filament sliding (GO:0033275)2.44364684
157positive regulation of lipoprotein lipase activity (GO:0051006)2.43509062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.05419591
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.84319183
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.91227062
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.67901545
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.67734258
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.59446066
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.02896387
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45453652
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.87359712
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.85225318
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23259161
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18004806
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13931114
14BCL6_27268052_Chip-Seq_Bcells_Human2.11036070
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06700238
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96692656
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95100895
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93572753
19* P68_20966046_ChIP-Seq_HELA_Human1.89807608
20GBX2_23144817_ChIP-Seq_PC3_Human1.87812141
21* VDR_21846776_ChIP-Seq_THP-1_Human1.81983938
22OCT4_20526341_ChIP-Seq_ESCs_Human1.77306689
23BCOR_27268052_Chip-Seq_Bcells_Human1.72590855
24* E2F1_20622854_ChIP-Seq_HELA_Human1.68151794
25SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.68127675
26GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.67104134
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.64990064
28* ELF1_20517297_ChIP-Seq_JURKAT_Human1.64086698
29GATA1_19941827_ChIP-Seq_MEL_Mouse1.62950834
30SA1_27219007_Chip-Seq_Bcells_Human1.62609179
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61214188
32P300_27268052_Chip-Seq_Bcells_Human1.56195773
33ERA_21632823_ChIP-Seq_H3396_Human1.55917020
34* PHF8_20622854_ChIP-Seq_HELA_Human1.54735217
35* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54696144
36RUNX_20019798_ChIP-Seq_JUKART_Human1.54198996
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53466346
38MAF_26560356_Chip-Seq_TH2_Human1.50253253
39RAC3_21632823_ChIP-Seq_H3396_Human1.49945698
40LXR_22292898_ChIP-Seq_THP-1_Human1.49538885
41MAF_26560356_Chip-Seq_TH1_Human1.47650007
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47604661
43* GATA1_19941826_ChIP-Seq_K562_Human1.45618702
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45535014
45* TAF2_19829295_ChIP-Seq_ESCs_Human1.45464761
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.43773746
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42578480
48* OCT4_19829295_ChIP-Seq_ESCs_Human1.37849412
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37197148
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34117811
51NANOG_20526341_ChIP-Seq_ESCs_Human1.33467047
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33236593
53UTX_26944678_Chip-Seq_JUKART_Human1.32564663
54SPI1_20517297_ChIP-Seq_HL60_Human1.31908869
55GATA3_26560356_Chip-Seq_TH2_Human1.31713678
56CTCF_21964334_ChIP-Seq_BJAB-B_Human1.31559952
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.29221891
58SMC4_20622854_ChIP-Seq_HELA_Human1.28639982
59EZH2_22144423_ChIP-Seq_EOC_Human1.28628288
60HTT_18923047_ChIP-ChIP_STHdh_Human1.26934017
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24133006
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.23928973
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23692742
64* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22841167
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21848705
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21380014
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21204699
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.20203429
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19479766
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18745060
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.18232837
72MYC_19829295_ChIP-Seq_ESCs_Human1.17979505
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17868600
74FOXH1_21741376_ChIP-Seq_ESCs_Human1.17720071
75NCOR_22424771_ChIP-Seq_293T_Human1.17256555
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16953786
77P53_21459846_ChIP-Seq_SAOS-2_Human1.16922590
78CTCF_20526341_ChIP-Seq_ESCs_Human1.16836226
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15152718
80* SOX2_21211035_ChIP-Seq_LN229_Human1.14678741
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14213986
82TAF15_26573619_Chip-Seq_HEK293_Human1.14157675
83MYB_26560356_Chip-Seq_TH2_Human1.13935255
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13513595
85SCL_19346495_ChIP-Seq_HPC-7_Human1.13078743
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12115246
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11296451
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10123298
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08714390
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08554471
91GATA3_27048872_Chip-Seq_THYMUS_Human1.08414479
92DROSHA_22980978_ChIP-Seq_HELA_Human1.07639757
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07516768
94* HNF4A_19822575_ChIP-Seq_HepG2_Human1.07286007
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06771994
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06435990
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05984024
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05774037
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03847830
100RARB_24833708_ChIP-Seq_LIVER_Mouse1.03564570
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02596156
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02281859
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.02215306
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.02113852
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01763415
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01623724
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01582410
108TP53_22573176_ChIP-Seq_HFKS_Human1.00071312
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.99630374
110GATA1_22025678_ChIP-Seq_K562_Human0.99278404
111CTCF_21964334_Chip-Seq_Bcells_Human0.99140598
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99034985
113EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98715072
114RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98715072
115KDM2B_26808549_Chip-Seq_DND41_Human0.97891834
116CTCF_26484167_Chip-Seq_Bcells_Mouse0.97255937
117REST_18959480_ChIP-ChIP_MESCs_Mouse0.96633206
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96536550
119FOXH1_21741376_ChIP-Seq_EPCs_Human0.96196424
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95225040
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93405393
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.93069066
123EZH2_27294783_Chip-Seq_ESCs_Mouse0.92837761
124JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92225392
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91001266
126BCAT_22108803_ChIP-Seq_LS180_Human0.87983039
127JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87385695
128* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84192778
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83985352
130* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83869135
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83522032
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83522032
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83350733
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82270503
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.82055436
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.81501839
137* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80564448
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79780374
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.79738318
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.79584339
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79138245
142AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78903662
143AR_21572438_ChIP-Seq_LNCaP_Human0.78606644
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78180595
145SMAD4_21799915_ChIP-Seq_A2780_Human0.76313089
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.75724553
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75588581
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.75406144
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75091200
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74411342
151TBX20_22080862_ChIP-Seq_HEART_Mouse0.74264866
152TBX20_22328084_ChIP-Seq_HEART_Mouse0.74264866
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.72758797
154CLOCK_20551151_ChIP-Seq_293T_Human0.70742967
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70709682
156P300_19829295_ChIP-Seq_ESCs_Human0.70226641
157ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69413747
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.68679577
159BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68617257
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68517453
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.67794564
162* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67514240
163TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67471769
164RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67190982
165RXRA_24833708_ChIP-Seq_LIVER_Mouse0.67071873
166SOX2_21211035_ChIP-Seq_LN229_Gbm0.66266520
167RUNX1_27457419_Chip-Seq_LIVER_Mouse0.65811447
168UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.65748848
169CBP_21632823_ChIP-Seq_H3396_Human0.65106349
170NR3C1_21868756_ChIP-Seq_MCF10A_Human0.64500440
171SMAD3_21741376_ChIP-Seq_HESCs_Human0.64272297
172CRX_20693478_ChIP-Seq_RETINA_Mouse0.64242022
173SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.64237960
174RARG_19884340_ChIP-ChIP_MEFs_Mouse0.63811396
175CTCF_27219007_Chip-Seq_Bcells_Human0.62415503
176AHR_22903824_ChIP-Seq_MCF-7_Human0.61784933
177REST_21632747_ChIP-Seq_MESCs_Mouse0.61616025
178ARNT_22903824_ChIP-Seq_MCF-7_Human0.60481728
179* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60013860
180EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.59430730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.09274246
2MP0005360_urolithiasis6.45589241
3MP0005085_abnormal_gallbladder_physiolo5.78942770
4MP0005365_abnormal_bile_salt5.49888511
5MP0008875_abnormal_xenobiotic_pharmacok4.35812272
6MP0003252_abnormal_bile_duct3.58793873
7MP0010329_abnormal_lipoprotein_level3.18858160
8MP0003195_calcinosis2.99997142
9MP0004145_abnormal_muscle_electrophysio2.99437440
10MP0003806_abnormal_nucleotide_metabolis2.99091064
11MP0005332_abnormal_amino_acid2.87003366
12MP0002837_dystrophic_cardiac_calcinosis2.72217391
13MP0005670_abnormal_white_adipose2.67551692
14MP0005083_abnormal_biliary_tract2.43793348
15MP0001666_abnormal_nutrient_absorption2.18403989
16MP0002118_abnormal_lipid_homeostasis2.18140217
17MP0004019_abnormal_vitamin_homeostasis2.17222155
18MP0009840_abnormal_foam_cell2.14938098
19MP0001986_abnormal_taste_sensitivity1.93884006
20MP0002138_abnormal_hepatobiliary_system1.92249036
21MP0003191_abnormal_cellular_cholesterol1.84904094
22MP0005451_abnormal_body_composition1.84373892
23MP0002653_abnormal_ependyma_morphology1.83422286
24MP0000609_abnormal_liver_physiology1.81038968
25MP0004130_abnormal_muscle_cell1.77758122
26MP0003646_muscle_fatigue1.75065280
27MP0003868_abnormal_feces_composition1.66754190
28MP0002132_abnormal_respiratory_system1.64878317
29MP0005319_abnormal_enzyme/_coenzyme1.64005451
30MP0004782_abnormal_surfactant_physiolog1.63549625
31MP0005666_abnormal_adipose_tissue1.61366354
32MP0001968_abnormal_touch/_nociception1.55881681
33MP0005584_abnormal_enzyme/coenzyme_acti1.53925868
34MP0002822_catalepsy1.52170101
35MP0001873_stomach_inflammation1.46804561
36MP0001764_abnormal_homeostasis1.45019361
37MP0005671_abnormal_response_to1.42114362
38MP0002971_abnormal_brown_adipose1.38318753
39MP0005535_abnormal_body_temperature1.36328043
40MP0001800_abnormal_humoral_immune1.36284733
41MP0006036_abnormal_mitochondrial_physio1.34900952
42MP0003763_abnormal_thymus_physiology1.32819931
43MP0009643_abnormal_urine_homeostasis1.31160260
44MP0004043_abnormal_pH_regulation1.26800128
45MP0002876_abnormal_thyroid_physiology1.24828278
46MP0002106_abnormal_muscle_physiology1.23844451
47MP0009333_abnormal_splenocyte_physiolog1.23105500
48MP0003436_decreased_susceptibility_to1.22751926
49MP0001502_abnormal_circadian_rhythm1.16958624
50MP0005330_cardiomyopathy1.14525986
51MP0005645_abnormal_hypothalamus_physiol1.11780641
52MP0005000_abnormal_immune_tolerance1.11518654
53MP0004215_abnormal_myocardial_fiber1.11239120
54MP0002078_abnormal_glucose_homeostasis1.11102427
55MP0002736_abnormal_nociception_after1.08613947
56MP0002723_abnormal_immune_serum1.05678485
57MP0003303_peritoneal_inflammation1.04391737
58MP0005334_abnormal_fat_pad1.04229297
59MP0005647_abnormal_sex_gland1.03936950
60MP0003879_abnormal_hair_cell1.03132941
61MP0000685_abnormal_immune_system1.01177913
62MP0005025_abnormal_response_to1.00963262
63MP0000751_myopathy1.00908711
64MP0009697_abnormal_copulation0.99653392
65MP0006082_CNS_inflammation0.96410331
66MP0002254_reproductive_system_inflammat0.96091501
67MP0005369_muscle_phenotype0.95634027
68MP0003011_delayed_dark_adaptation0.95200309
69MP0009745_abnormal_behavioral_response0.94879195
70MP0003656_abnormal_erythrocyte_physiolo0.94253749
71MP0005636_abnormal_mineral_homeostasis0.93916210
72MP0001501_abnormal_sleep_pattern0.93567838
73MP0005423_abnormal_somatic_nervous0.93035644
74MP0009785_altered_susceptibility_to0.91951362
75MP0009764_decreased_sensitivity_to0.91939929
76MP0008995_early_reproductive_senescence0.91037667
77MP0009278_abnormal_bone_marrow0.91000622
78MP0002420_abnormal_adaptive_immunity0.90157737
79MP0005397_hematopoietic_system_phenotyp0.89335430
80MP0001545_abnormal_hematopoietic_system0.89335430
81MP0004185_abnormal_adipocyte_glucose0.89253071
82MP0001819_abnormal_immune_cell0.87281595
83MP0005375_adipose_tissue_phenotype0.85347201
84MP0004036_abnormal_muscle_relaxation0.84108027
85MP0005387_immune_system_phenotype0.83209757
86MP0001790_abnormal_immune_system0.83209757
87MP0002735_abnormal_chemical_nociception0.82980136
88MP0000689_abnormal_spleen_morphology0.82216165
89MP0009642_abnormal_blood_homeostasis0.82037798
90MP0005448_abnormal_energy_balance0.81491492
91MP0003186_abnormal_redox_activity0.80533052
92MP0003878_abnormal_ear_physiology0.79730992
93MP0005377_hearing/vestibular/ear_phenot0.79730992
94MP0000681_abnormal_thyroid_gland0.78468062
95MP0002398_abnormal_bone_marrow0.78276937
96MP0003690_abnormal_glial_cell0.78015767
97MP0003183_abnormal_peptide_metabolism0.77552862
98MP0008877_abnormal_DNA_methylation0.77460466
99MP0004142_abnormal_muscle_tone0.77438721
100MP0003137_abnormal_impulse_conducting0.77016541
101MP0000372_irregular_coat_pigmentation0.76511607
102MP0000230_abnormal_systemic_arterial0.75748003
103MP0000759_abnormal_skeletal_muscle0.75012682
104MP0000716_abnormal_immune_system0.74258785
105MP0002064_seizures0.73795181
106MP0002452_abnormal_antigen_presenting0.73130681
107MP0006276_abnormal_autonomic_nervous0.73045158
108MP0005620_abnormal_muscle_contractility0.72768847
109MP0001661_extended_life_span0.72316232
110MP0009763_increased_sensitivity_to0.71743215
111MP0000749_muscle_degeneration0.70694465
112MP0000598_abnormal_liver_morphology0.70658753
113MP0006138_congestive_heart_failure0.69970415
114MP0001756_abnormal_urination0.67236381
115MP0003953_abnormal_hormone_level0.66775522
116MP0006035_abnormal_mitochondrial_morpho0.66725075
117MP0004085_abnormal_heartbeat0.66557014
118MP0002972_abnormal_cardiac_muscle0.65243600
119MP0008775_abnormal_heart_ventricle0.65181520
120MP0001765_abnormal_ion_homeostasis0.64886895
121MP0000604_amyloidosis0.64594674
122MP0005376_homeostasis/metabolism_phenot0.64437406
123MP0008874_decreased_physiological_sensi0.63458038
124MP0010368_abnormal_lymphatic_system0.61996465
125MP0002269_muscular_atrophy0.61727564
126MP0005084_abnormal_gallbladder_morpholo0.61635453
127MP0005266_abnormal_metabolism0.60515700
128MP0009115_abnormal_fat_cell0.59354963
129MP0000566_synostosis0.59193674
130MP0008872_abnormal_physiological_respon0.59098075
131MP0001544_abnormal_cardiovascular_syste0.59073148
132MP0005385_cardiovascular_system_phenoty0.59073148
133MP0005646_abnormal_pituitary_gland0.57517910
134MP0004084_abnormal_cardiac_muscle0.56571196
135MP0004087_abnormal_muscle_fiber0.55534987
136MP0008469_abnormal_protein_level0.54632473
137MP0003329_amyloid_beta_deposits0.53666595
138MP0002332_abnormal_exercise_endurance0.52958941
139MP0004147_increased_porphyrin_level0.52507626
140MP0009780_abnormal_chondrocyte_physiolo0.52271355
141MP0004381_abnormal_hair_follicle0.50583600
142MP0005595_abnormal_vascular_smooth0.49180830
143MP0008961_abnormal_basal_metabolism0.48544653
144MP0000579_abnormal_nail_morphology0.48425028
145MP0002970_abnormal_white_adipose0.47753953
146MP0002136_abnormal_kidney_physiology0.45004486
147MP0005551_abnormal_eye_electrophysiolog0.44561584
148MP0009765_abnormal_xenobiotic_induced0.44257286
149MP0005452_abnormal_adipose_tissue0.43840929
150MP0002928_abnormal_bile_duct0.42396025
151MP0000747_muscle_weakness0.42106604

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.77565898
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.76868941
3Deep venous thrombosis (HP:0002625)5.36100148
4Prolonged partial thromboplastin time (HP:0003645)5.31589203
5Xanthomatosis (HP:0000991)4.92097764
6Hyperglycinuria (HP:0003108)4.91959276
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.81349957
8Ketosis (HP:0001946)4.77015957
9Hyperlipoproteinemia (HP:0010980)4.63451968
10Hyperammonemia (HP:0001987)4.61224301
11Hypoglycemic coma (HP:0001325)4.53692246
12Abnormality of glycine metabolism (HP:0010895)4.52458886
13Abnormality of serine family amino acid metabolism (HP:0010894)4.52458886
14Hyperglycinemia (HP:0002154)4.41617403
15Abnormality of fatty-acid metabolism (HP:0004359)4.16879298
16Hypobetalipoproteinemia (HP:0003563)4.11070427
17Ketoacidosis (HP:0001993)4.10503522
18Complement deficiency (HP:0004431)4.04790853
19Muscle fiber inclusion bodies (HP:0100299)4.00117814
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99645991
21Joint hemorrhage (HP:0005261)3.83263972
22Nemaline bodies (HP:0003798)3.80398100
23Hypoalphalipoproteinemia (HP:0003233)3.77533302
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.74160301
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.66573470
26Dicarboxylic aciduria (HP:0003215)3.66455776
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.66455776
28Epidermoid cyst (HP:0200040)3.63656919
29Hypolipoproteinemia (HP:0010981)3.62377007
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.59335499
31Hypochromic anemia (HP:0001931)3.55728926
32Abnormality of methionine metabolism (HP:0010901)3.40589460
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.38736562
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.36062669
35Metabolic acidosis (HP:0001942)3.21347511
36Conjugated hyperbilirubinemia (HP:0002908)3.17139638
37Abnormality of serum amino acid levels (HP:0003112)3.10652461
38Abnormality of the common coagulation pathway (HP:0010990)3.10104148
39Generalized aminoaciduria (HP:0002909)3.07061671
40Fat malabsorption (HP:0002630)3.03057398
41Renal cortical cysts (HP:0000803)3.01296903
42Cerebral edema (HP:0002181)2.96918975
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.94778079
44Lethargy (HP:0001254)2.93048282
45Gastrointestinal infarctions (HP:0005244)2.91177355
46Congenital stationary night blindness (HP:0007642)2.90166659
47Delayed CNS myelination (HP:0002188)2.85337166
48Myoglobinuria (HP:0002913)2.82619313
49Gout (HP:0001997)2.79114882
50Abnormality of eosinophils (HP:0001879)2.77944108
51Hyperbilirubinemia (HP:0002904)2.77560538
52Abnormality of purine metabolism (HP:0004352)2.76599626
53Abnormality of nucleobase metabolism (HP:0010932)2.75219593
54Myopathic facies (HP:0002058)2.72999917
55Proximal tubulopathy (HP:0000114)2.72789325
56Hypercholesterolemia (HP:0003124)2.72468470
57Abnormality of pyrimidine metabolism (HP:0004353)2.72459527
58Abnormality of complement system (HP:0005339)2.71211236
59Poikilocytosis (HP:0004447)2.70344055
60Hemorrhage of the eye (HP:0011885)2.69931812
61Hypoglycemic seizures (HP:0002173)2.69605288
62Type 1 muscle fiber predominance (HP:0003803)2.68952975
63Stomatitis (HP:0010280)2.68461036
64Neck muscle weakness (HP:0000467)2.68098328
65Hydroxyprolinuria (HP:0003080)2.67334645
66Abnormality of proline metabolism (HP:0010907)2.67334645
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.62735185
68Muscle hypertrophy of the lower extremities (HP:0008968)2.62524572
69Abnormality of the intrinsic pathway (HP:0010989)2.62002157
70Hyperinsulinemic hypoglycemia (HP:0000825)2.60938466
71Vascular calcification (HP:0004934)2.55253509
72Elevated erythrocyte sedimentation rate (HP:0003565)2.51400506
73Vomiting (HP:0002013)2.50403016
74Increased IgM level (HP:0003496)2.45379612
75Enlarged kidneys (HP:0000105)2.40848595
76Skin nodule (HP:0200036)2.36522020
77Calf muscle hypertrophy (HP:0008981)2.33552977
78Exercise-induced myalgia (HP:0003738)2.31658329
79Hyperventilation (HP:0002883)2.30597023
80Myocardial infarction (HP:0001658)2.28865985
81Abnormal gallbladder morphology (HP:0012437)2.27035887
82Cholelithiasis (HP:0001081)2.26740841
83Hypochromic microcytic anemia (HP:0004840)2.26373480
84Steatorrhea (HP:0002570)2.24640375
85Increased purine levels (HP:0004368)2.22294873
86Hyperuricemia (HP:0002149)2.22294873
87Sensorimotor neuropathy (HP:0007141)2.22284858
88Cardiovascular calcification (HP:0011915)2.21407205
89Glycosuria (HP:0003076)2.20798582
90Abnormality of urine glucose concentration (HP:0011016)2.20798582
91Abnormality of T cell physiology (HP:0011840)2.19254970
92Reticulocytosis (HP:0001923)2.16748309
93Hepatic necrosis (HP:0002605)2.16531238
94Stomach cancer (HP:0012126)2.15294174
95Spontaneous abortion (HP:0005268)2.15237550
96Neonatal onset (HP:0003623)2.14361736
97Distal arthrogryposis (HP:0005684)2.12141789
98Anorexia (HP:0002039)2.12123966
99Recurrent gram-negative bacterial infections (HP:0005420)2.09143652
100Increased muscle lipid content (HP:0009058)2.08784704
101Hepatocellular carcinoma (HP:0001402)2.08678953
102Encephalitis (HP:0002383)2.08458093
103Rhabdomyolysis (HP:0003201)2.08222644
104Pancreatitis (HP:0001733)2.08039784
105Ulnar deviation of the wrist (HP:0003049)2.07954640
106Sudden death (HP:0001699)2.06024378
107Attenuation of retinal blood vessels (HP:0007843)2.05606310
108Symptomatic seizures (HP:0011145)2.05092461
109Hyperglycemia (HP:0003074)2.04347885
110Panhypogammaglobulinemia (HP:0003139)2.03784074
111Late onset (HP:0003584)2.02164818
112Increased serum ferritin (HP:0003281)2.01761591
113Acute encephalopathy (HP:0006846)2.01747213
114Methylmalonic aciduria (HP:0012120)2.01499943
115Alkalosis (HP:0001948)2.01149459
116Muscle fiber splitting (HP:0003555)2.00712082
117Chronic hepatic failure (HP:0100626)2.00675539
118Abnormality of transition element cation homeostasis (HP:0011030)1.98515124
119Hypophosphatemic rickets (HP:0004912)1.98200218
120Abnormality of iron homeostasis (HP:0011031)1.98039342
121Eosinophilia (HP:0001880)1.97821137
122Cheilitis (HP:0100825)1.97216562
123Rickets (HP:0002748)1.96952679
124Myositis (HP:0100614)1.96748259
125Meningitis (HP:0001287)1.96743440
126Round ear (HP:0100830)1.96022964
127Methylmalonic acidemia (HP:0002912)1.95335843
128Cerebral palsy (HP:0100021)1.95147516
129Exercise-induced muscle cramps (HP:0003710)1.95088470
130EMG: myopathic abnormalities (HP:0003458)1.92212197
131Confusion (HP:0001289)1.91895375
132Nausea (HP:0002018)1.91796065
133Abnormality of the fingertips (HP:0001211)1.91033479
134Granulocytopenia (HP:0001913)1.90515929
135Status epilepticus (HP:0002133)1.89719625
136Irritability (HP:0000737)1.89528711
137Hyperthyroidism (HP:0000836)1.89226855
138Systemic lupus erythematosus (HP:0002725)1.88834651
139Asymmetric septal hypertrophy (HP:0001670)1.87603173
140Hyporeflexia of lower limbs (HP:0002600)1.86949778
141Atrioventricular block (HP:0001678)1.85813384
142Brushfield spots (HP:0001088)1.84914330
143Muscle stiffness (HP:0003552)1.84293135
144Retrobulbar optic neuritis (HP:0100654)1.84242409
145Optic neuritis (HP:0100653)1.84242409
146Abnormality of vitamin metabolism (HP:0100508)1.84064019
147Abnormality of the gallbladder (HP:0005264)1.83929963
148Mesangial abnormality (HP:0001966)1.83573776
149Mitral stenosis (HP:0001718)1.83178796
150Long clavicles (HP:0000890)1.81945263
151Cholecystitis (HP:0001082)1.81613366
152Abnormal gallbladder physiology (HP:0012438)1.81613366
153Recurrent fungal infections (HP:0002841)1.80280287
154Decreased central vision (HP:0007663)1.78106921
155EMG: neuropathic changes (HP:0003445)1.77881107
156Heart block (HP:0012722)1.77040810
157Prolonged bleeding time (HP:0003010)1.72478573
158Keratoconjunctivitis (HP:0001096)1.71545218
159Abnormality of T cells (HP:0002843)1.69348160
160Dyskinesia (HP:0100660)1.69119121
161Conical tooth (HP:0000698)1.68930504
162Vasculitis (HP:0002633)1.67826204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.38035833
2INSRR3.95270176
3SIK13.35304547
4MAP4K12.99541532
5FGFR42.53959714
6PINK12.26309918
7TNK22.23466661
8RIPK42.05620582
9TXK2.01459118
10TLK11.88561624
11EPHA41.87327483
12TAOK21.86777158
13MAP2K41.85870486
14ERN11.77173083
15ITK1.71476458
16PDK41.67286991
17PDK31.67286991
18PHKG11.65864957
19PHKG21.65864957
20TAOK31.61468041
21WNK41.59291881
22GRK61.53660495
23OBSCN1.50119361
24ERBB41.48670466
25PRKAA21.46699522
26TIE11.44644096
27SYK1.42243375
28MAP3K71.40552859
29MST1R1.38618416
30MAPK131.35485713
31CAMK1D1.33405828
32DAPK21.30197559
33PIK3CG1.30129045
34CAMK1G1.27925918
35PRPF4B1.26461507
36CASK1.26428767
37GRK71.25118977
38PKN11.23928955
39MAPK111.20355253
40STK38L1.19321763
41MAPK151.19092282
42BTK1.18437497
43FES1.16908544
44MAPK121.16600295
45MAPKAPK31.15683970
46ZAP701.13245674
47MYLK1.13222922
48MAP4K21.12793931
49MAP2K21.12219283
50SIK21.11763248
51PDK21.11734824
52BLK1.11310214
53IKBKB1.11029788
54TYK21.09837533
55MAP3K111.08187860
56SGK31.07952738
57PIK3CA1.07410815
58SGK21.06146686
59MUSK1.04557450
60OXSR11.04467348
61RIPK11.04366744
62LATS11.03136827
63WNK31.00703780
64ADRBK21.00619332
65IRAK40.98536494
66SGK2230.98102789
67SGK4940.98102789
68TTN0.96405706
69TNIK0.96184650
70PDPK10.96087715
71PRKAA10.96064882
72IRAK30.94767438
73CAMKK10.94499347
74LCK0.94298475
75MARK30.92330480
76LMTK20.91683519
77TRIB30.91535400
78STK380.89834290
79PTK2B0.86919296
80FGFR20.86462171
81SIK30.86182371
82HCK0.82930953
83NTRK30.80652510
84MARK10.78689927
85HIPK20.77822197
86CAMK2G0.77067073
87PRKACG0.76863008
88MAPK70.76714942
89MAP3K40.74971562
90JAK10.73923571
91JAK30.70856991
92CAMK2A0.69823289
93DMPK0.68948450
94GRK10.68179051
95PRKCI0.68108416
96MAP2K70.67575180
97PRKD10.67482809
98TESK20.66756699
99PIM10.66660755
100CAMK40.66361485
101EPHB10.65708361
102PRKCZ0.65442904
103MAP3K140.62576049
104PDK10.62091973
105ABL20.61943098
106CAMK10.61670981
107MAP2K10.61485023
108STK390.61076163
109BMPR20.60971730
110CAMK2D0.60437801
111PAK30.59519904
112LYN0.58460913
113PKN20.58075003
114SGK10.57081729
115TEC0.56459866
116PRKACA0.56077994
117TBK10.56019037
118JAK20.56012248
119MAP3K60.55883009
120PRKCH0.55422968
121CCNB10.55104740
122MAP2K30.54127761
123PRKCQ0.53905633
124FLT30.52917925
125AKT30.52510079
126TGFBR20.50463866
127IRAK20.50138910
128MAPK40.48819831
129PRKCE0.48540744
130PRKCG0.48482106
131IKBKE0.47886802
132FRK0.47845480
133RPS6KA60.47468695
134ZAK0.46725259
135ERBB20.44542071
136MAP3K130.44313770
137CDK40.44206338
138MAPK30.43259424
139RPS6KA50.43173521
140MARK20.42862438
141WNK10.42829093
142CAMKK20.42223265
143PRKD20.41310911
144RPS6KB10.41006000
145CDK190.40147372
146CSNK1A10.38906741
147PRKCA0.38202845
148STK110.37916591
149MAP2K60.37555967

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.72330552
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.15464954
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08144695
4Fatty acid degradation_Homo sapiens_hsa000713.07966375
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97631578
6Propanoate metabolism_Homo sapiens_hsa006402.88694749
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74537075
8Nitrogen metabolism_Homo sapiens_hsa009102.71817965
9Tryptophan metabolism_Homo sapiens_hsa003802.70184814
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64582606
11Arginine biosynthesis_Homo sapiens_hsa002202.58759086
12Butanoate metabolism_Homo sapiens_hsa006502.57402974
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53920973
14Fatty acid metabolism_Homo sapiens_hsa012122.44674134
15PPAR signaling pathway_Homo sapiens_hsa033202.17038554
16Peroxisome_Homo sapiens_hsa041462.11098819
17Complement and coagulation cascades_Homo sapiens_hsa046102.09967763
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04657339
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04358357
20beta-Alanine metabolism_Homo sapiens_hsa004101.98775997
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95686862
22Primary immunodeficiency_Homo sapiens_hsa053401.93244047
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83483992
24Fatty acid elongation_Homo sapiens_hsa000621.82415230
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78282703
26Pyruvate metabolism_Homo sapiens_hsa006201.69020071
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67918387
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.67359661
29Histidine metabolism_Homo sapiens_hsa003401.66446157
30Chemical carcinogenesis_Homo sapiens_hsa052041.56158118
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55183258
32Phototransduction_Homo sapiens_hsa047441.54589401
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49600378
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47863630
35Ether lipid metabolism_Homo sapiens_hsa005651.46921795
36Phenylalanine metabolism_Homo sapiens_hsa003601.46272966
37Retinol metabolism_Homo sapiens_hsa008301.45392614
38Bile secretion_Homo sapiens_hsa049761.42737122
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34955937
40Carbon metabolism_Homo sapiens_hsa012001.34481869
41Starch and sucrose metabolism_Homo sapiens_hsa005001.33210109
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31312011
43Tyrosine metabolism_Homo sapiens_hsa003501.30578452
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24875125
45Staphylococcus aureus infection_Homo sapiens_hsa051501.23858775
46Sulfur metabolism_Homo sapiens_hsa009201.23854079
47ABC transporters_Homo sapiens_hsa020101.23263063
48Caffeine metabolism_Homo sapiens_hsa002321.22553617
49Arachidonic acid metabolism_Homo sapiens_hsa005901.22018899
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.18485384
51Autoimmune thyroid disease_Homo sapiens_hsa053201.15845501
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09425047
53Lysine degradation_Homo sapiens_hsa003101.08304308
54Graft-versus-host disease_Homo sapiens_hsa053321.02682459
55Fatty acid biosynthesis_Homo sapiens_hsa000611.02118011
56Selenocompound metabolism_Homo sapiens_hsa004500.99340778
57Arginine and proline metabolism_Homo sapiens_hsa003300.98548074
58Fat digestion and absorption_Homo sapiens_hsa049750.95623721
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93262688
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.92267292
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91470324
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.91418745
63Biosynthesis of amino acids_Homo sapiens_hsa012300.91311472
64Steroid biosynthesis_Homo sapiens_hsa001000.89372476
65Glycerolipid metabolism_Homo sapiens_hsa005610.89007965
66Vitamin digestion and absorption_Homo sapiens_hsa049770.81779117
67Allograft rejection_Homo sapiens_hsa053300.80481268
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79551807
69Folate biosynthesis_Homo sapiens_hsa007900.74777624
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.73630026
71Vitamin B6 metabolism_Homo sapiens_hsa007500.70337995
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69678419
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65581313
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.63470148
75Sulfur relay system_Homo sapiens_hsa041220.60241786
76T cell receptor signaling pathway_Homo sapiens_hsa046600.53813114
77Metabolic pathways_Homo sapiens_hsa011000.49781466
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.48728381
79Type I diabetes mellitus_Homo sapiens_hsa049400.47968393
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.46319982
81Glutathione metabolism_Homo sapiens_hsa004800.43669420
82Regulation of autophagy_Homo sapiens_hsa041400.43475245
83Insulin resistance_Homo sapiens_hsa049310.40851003
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40369527
85Glucagon signaling pathway_Homo sapiens_hsa049220.39675657
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36549317
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34202813
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.34174205
89B cell receptor signaling pathway_Homo sapiens_hsa046620.33563982
90Hematopoietic cell lineage_Homo sapiens_hsa046400.32770934
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30983991
92Oxidative phosphorylation_Homo sapiens_hsa001900.27745647
93Cardiac muscle contraction_Homo sapiens_hsa042600.27586021
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25432699
95Olfactory transduction_Homo sapiens_hsa047400.25101499
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24654576
97Linoleic acid metabolism_Homo sapiens_hsa005910.22779188
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22757931
99Dorso-ventral axis formation_Homo sapiens_hsa043200.22315249
100Fructose and mannose metabolism_Homo sapiens_hsa000510.21524773
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21247113
102Pentose phosphate pathway_Homo sapiens_hsa000300.21140348
103mTOR signaling pathway_Homo sapiens_hsa041500.20797395
104AMPK signaling pathway_Homo sapiens_hsa041520.20611723
105Ovarian steroidogenesis_Homo sapiens_hsa049130.17631035
106Galactose metabolism_Homo sapiens_hsa000520.17355236
107Alzheimers disease_Homo sapiens_hsa050100.14378451
108Prion diseases_Homo sapiens_hsa050200.11509874
109Parkinsons disease_Homo sapiens_hsa050120.11044907
110Type II diabetes mellitus_Homo sapiens_hsa049300.10051348
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09778413
112Insulin signaling pathway_Homo sapiens_hsa049100.08963793
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08374397
114Nicotine addiction_Homo sapiens_hsa050330.08063472
115GABAergic synapse_Homo sapiens_hsa047270.07483470
116Dilated cardiomyopathy_Homo sapiens_hsa054140.06381665
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03419850
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.02958052
119One carbon pool by folate_Homo sapiens_hsa006700.02885678
120Circadian rhythm_Homo sapiens_hsa047100.02572554
121Calcium signaling pathway_Homo sapiens_hsa040200.02092094
122Taste transduction_Homo sapiens_hsa047420.01909036
123Insulin secretion_Homo sapiens_hsa049110.01690732
124Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0375875
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0358189
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0090511

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