SLC25A3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.90211317
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.15801998
3ATP synthesis coupled proton transport (GO:0015986)5.15801998
4water-soluble vitamin biosynthetic process (GO:0042364)4.99895976
5L-methionine salvage (GO:0071267)4.95410212
6L-methionine biosynthetic process (GO:0071265)4.95410212
7amino acid salvage (GO:0043102)4.95410212
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.90917775
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77844754
10proteasome assembly (GO:0043248)4.65911933
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.42427536
12cullin deneddylation (GO:0010388)4.14954874
13electron transport chain (GO:0022900)4.06576875
14respiratory electron transport chain (GO:0022904)4.05638292
15respiratory chain complex IV assembly (GO:0008535)4.02943840
16methionine biosynthetic process (GO:0009086)4.02815915
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91927220
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.91927220
19NADH dehydrogenase complex assembly (GO:0010257)3.91927220
20protein complex biogenesis (GO:0070271)3.78858760
21peptidyl-histidine modification (GO:0018202)3.74006215
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.73837193
23termination of RNA polymerase III transcription (GO:0006386)3.73837193
24protein deneddylation (GO:0000338)3.73691699
25one-carbon compound transport (GO:0019755)3.70040690
26DNA synthesis involved in DNA repair (GO:0000731)3.63103800
27sequestering of actin monomers (GO:0042989)3.62302363
28metallo-sulfur cluster assembly (GO:0031163)3.62115318
29iron-sulfur cluster assembly (GO:0016226)3.62115318
30regulation of cilium movement (GO:0003352)3.61475434
31mitochondrial respiratory chain complex assembly (GO:0033108)3.60385548
32DNA deamination (GO:0045006)3.59688301
33ATP biosynthetic process (GO:0006754)3.45483374
34negative regulation of heart rate (GO:0010459)3.44303145
35regulation of helicase activity (GO:0051095)3.38781643
36piRNA metabolic process (GO:0034587)3.37737297
37methionine metabolic process (GO:0006555)3.34804624
38centriole replication (GO:0007099)3.34318924
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33149472
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31797407
41aspartate family amino acid biosynthetic process (GO:0009067)3.28184349
42negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.26962181
43positive regulation of lamellipodium assembly (GO:0010592)3.25714263
44S-adenosylmethionine metabolic process (GO:0046500)3.24716472
45protein neddylation (GO:0045116)3.24543737
46regulation of cellular amino acid metabolic process (GO:0006521)3.19946726
47protein prenylation (GO:0018342)3.18567737
48prenylation (GO:0097354)3.18567737
49deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.15096294
50hydrogen ion transmembrane transport (GO:1902600)3.11875257
51branched-chain amino acid catabolic process (GO:0009083)3.10799985
52mismatch repair (GO:0006298)3.10770759
53oxidative phosphorylation (GO:0006119)3.10560541
54rRNA modification (GO:0000154)3.09109303
55platelet dense granule organization (GO:0060155)3.07008729
56axoneme assembly (GO:0035082)3.06843404
57regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.06825475
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04497778
59cytochrome complex assembly (GO:0017004)3.03245552
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03158945
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96149121
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95496926
63proton transport (GO:0015992)2.95026151
64neural tube formation (GO:0001841)2.95003082
65sulfur amino acid biosynthetic process (GO:0000097)2.92680173
66transepithelial transport (GO:0070633)2.89905971
67hydrogen transport (GO:0006818)2.89640958
68regulation of regulatory T cell differentiation (GO:0045589)2.88980322
69mitochondrial RNA metabolic process (GO:0000959)2.88812498
70B cell mediated immunity (GO:0019724)2.86903074
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86152773
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86152773
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.84554194
74immunoglobulin mediated immune response (GO:0016064)2.83370274
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83238386
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83238386
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83238386
78negative regulation of appetite (GO:0032099)2.81252257
79negative regulation of response to food (GO:0032096)2.81252257
80deoxyribose phosphate biosynthetic process (GO:0046385)2.80411702
812-deoxyribonucleotide biosynthetic process (GO:0009265)2.80411702
82regulation of acyl-CoA biosynthetic process (GO:0050812)2.79754602
83GPI anchor metabolic process (GO:0006505)2.77562601
84mannosylation (GO:0097502)2.77117705
85protein targeting to mitochondrion (GO:0006626)2.76275075
86GPI anchor biosynthetic process (GO:0006506)2.75698047
87xenobiotic catabolic process (GO:0042178)2.73717556
88purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.72624339
89signal transduction involved in DNA damage checkpoint (GO:0072422)2.72083228
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72083228
91spliceosomal snRNP assembly (GO:0000387)2.66656627
92autophagic vacuole fusion (GO:0000046)2.66619235
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63728487
94establishment of protein localization to mitochondrion (GO:0072655)2.63573403
95cytidine metabolic process (GO:0046087)2.62982808
96cytidine catabolic process (GO:0006216)2.62982808
97cytidine deamination (GO:0009972)2.62982808
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.62075941
99aldehyde catabolic process (GO:0046185)2.60242199
100chaperone-mediated protein transport (GO:0072321)2.60100425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.40793260
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.31104859
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22396780
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.01075625
5VDR_22108803_ChIP-Seq_LS180_Human3.56103532
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00219799
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.94305824
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91667998
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74497571
10VDR_23849224_ChIP-Seq_CD4+_Human2.66056508
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58370368
12IGF1R_20145208_ChIP-Seq_DFB_Human2.31442968
13ELK1_19687146_ChIP-ChIP_HELA_Human2.28319555
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.26573067
15ZNF274_21170338_ChIP-Seq_K562_Hela2.25905647
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17684642
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94244810
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91455447
19FOXP3_21729870_ChIP-Seq_TREG_Human1.90535556
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85186493
21HTT_18923047_ChIP-ChIP_STHdh_Human1.78497433
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.76532905
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.70436602
24EWS_26573619_Chip-Seq_HEK293_Human1.68411995
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68010006
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.67202294
27TAF15_26573619_Chip-Seq_HEK293_Human1.66919287
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65112624
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63555501
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59191019
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59146713
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57948363
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57725792
34CIITA_25753668_ChIP-Seq_RAJI_Human1.55350516
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.53939372
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51886191
37AR_20517297_ChIP-Seq_VCAP_Human1.48342408
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44209654
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40189731
40NCOR_22424771_ChIP-Seq_293T_Human1.39672420
41TP53_22573176_ChIP-Seq_HFKS_Human1.39531604
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39518407
43GABP_19822575_ChIP-Seq_HepG2_Human1.39449322
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37971613
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37371984
46GBX2_23144817_ChIP-Seq_PC3_Human1.37101605
47MYC_18940864_ChIP-ChIP_HL60_Human1.34629059
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33831739
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32686302
50ER_23166858_ChIP-Seq_MCF-7_Human1.32060396
51IRF1_19129219_ChIP-ChIP_H3396_Human1.29459500
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23534086
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22960010
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22172301
55SOX2_19829295_ChIP-Seq_ESCs_Human1.21609637
56NANOG_19829295_ChIP-Seq_ESCs_Human1.21609637
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.21386166
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21386166
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21340505
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20924586
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20865668
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20243346
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19898135
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.17344845
65P300_19829295_ChIP-Seq_ESCs_Human1.14248541
66DCP1A_22483619_ChIP-Seq_HELA_Human1.13682331
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12490055
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09315099
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08525348
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07186279
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06813371
72RBPJ_21746931_ChIP-Seq_IB4_Human1.06791443
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05541013
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05260859
75GATA3_26560356_Chip-Seq_TH2_Human1.05109363
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.03319361
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.03167203
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03028869
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02137967
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00696509
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.97890861
82CBP_20019798_ChIP-Seq_JUKART_Human0.97880201
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97880201
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.97525281
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.96793227
86NANOG_20526341_ChIP-Seq_ESCs_Human0.96593050
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96365772
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.96250723
89MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95332964
90ERG_20517297_ChIP-Seq_VCAP_Human0.95054714
91FUS_26573619_Chip-Seq_HEK293_Human0.95040543
92ERA_21632823_ChIP-Seq_H3396_Human0.94255938
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.93844409
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92554414
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92095587
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91928810
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90956915
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90950379
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90793376
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89976254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.41334879
2MP0002102_abnormal_ear_morphology2.92167245
3MP0008058_abnormal_DNA_repair2.88313770
4MP0005671_abnormal_response_to2.88028931
5MP0005360_urolithiasis2.46642966
6MP0009697_abnormal_copulation2.38145905
7MP0002837_dystrophic_cardiac_calcinosis2.36697906
8MP0003787_abnormal_imprinting2.29009096
9MP0008877_abnormal_DNA_methylation2.25117913
10MP0006292_abnormal_olfactory_placode2.21366621
11MP0000372_irregular_coat_pigmentation2.15998971
12MP0008995_early_reproductive_senescence2.15628780
13MP0008789_abnormal_olfactory_epithelium2.08311110
14MP0006072_abnormal_retinal_apoptosis2.05103784
15MP0005645_abnormal_hypothalamus_physiol1.91689109
16MP0008875_abnormal_xenobiotic_pharmacok1.91534674
17MP0003880_abnormal_central_pattern1.86216567
18MP0001835_abnormal_antigen_presentation1.82499189
19MP0003724_increased_susceptibility_to1.81959230
20MP0006036_abnormal_mitochondrial_physio1.76282737
21MP0009333_abnormal_splenocyte_physiolog1.76012410
22MP0005085_abnormal_gallbladder_physiolo1.74518540
23MP0003806_abnormal_nucleotide_metabolis1.70121707
24MP0003786_premature_aging1.69979908
25MP0006035_abnormal_mitochondrial_morpho1.68010316
26MP0001968_abnormal_touch/_nociception1.64613814
27MP0002876_abnormal_thyroid_physiology1.60202110
28MP0003137_abnormal_impulse_conducting1.58390221
29MP0005075_abnormal_melanosome_morpholog1.58042039
30MP0001485_abnormal_pinna_reflex1.55971713
31MP0004142_abnormal_muscle_tone1.54552521
32MP0002736_abnormal_nociception_after1.52329841
33MP0001873_stomach_inflammation1.50156620
34MP0005389_reproductive_system_phenotype1.46752287
35MP0000516_abnormal_urinary_system1.45581680
36MP0005367_renal/urinary_system_phenotyp1.45581680
37MP0001986_abnormal_taste_sensitivity1.43877705
38MP0005253_abnormal_eye_physiology1.43861694
39MP0005394_taste/olfaction_phenotype1.40895634
40MP0005499_abnormal_olfactory_system1.40895634
41MP0005551_abnormal_eye_electrophysiolog1.38164772
42MP0009764_decreased_sensitivity_to1.37064635
43MP0001919_abnormal_reproductive_system1.36474807
44MP0003646_muscle_fatigue1.31360781
45MP0005332_abnormal_amino_acid1.31047225
46MP0005646_abnormal_pituitary_gland1.29272653
47MP0003718_maternal_effect1.28951556
48MP0004145_abnormal_muscle_electrophysio1.28122481
49MP0009046_muscle_twitch1.25323348
50MP0004043_abnormal_pH_regulation1.22119160
51MP0001905_abnormal_dopamine_level1.21712984
52MP0001756_abnormal_urination1.21210182
53MP0003186_abnormal_redox_activity1.20813446
54MP0003195_calcinosis1.20529408
55MP0002751_abnormal_autonomic_nervous1.19655693
56MP0008872_abnormal_physiological_respon1.16407598
57MP0002166_altered_tumor_susceptibility1.15470723
58MP0005636_abnormal_mineral_homeostasis1.14841855
59MP0001119_abnormal_female_reproductive1.11990625
60MP0005379_endocrine/exocrine_gland_phen1.11038464
61MP0009785_altered_susceptibility_to1.10691077
62MP0002210_abnormal_sex_determination1.09767630
63MP0001984_abnormal_olfaction1.09574556
64MP0002277_abnormal_respiratory_mucosa1.09500761
65MP0003866_abnormal_defecation1.05834467
66MP0002095_abnormal_skin_pigmentation1.04548909
67MP0005084_abnormal_gallbladder_morpholo1.03915901
68MP0001764_abnormal_homeostasis1.02216161
69MP0001929_abnormal_gametogenesis1.00193543
70MP0001800_abnormal_humoral_immune0.98179308
71MP0001529_abnormal_vocalization0.98087837
72MP0002160_abnormal_reproductive_system0.96892571
73MP0002234_abnormal_pharynx_morphology0.94540453
74MP0000631_abnormal_neuroendocrine_gland0.94081067
75MP0009745_abnormal_behavioral_response0.93703200
76MP0002638_abnormal_pupillary_reflex0.93305442
77MP0000026_abnormal_inner_ear0.92476169
78MP0002693_abnormal_pancreas_physiology0.90661121
79MP0009643_abnormal_urine_homeostasis0.89844041
80MP0002148_abnormal_hypersensitivity_rea0.88565203
81MP0006276_abnormal_autonomic_nervous0.88246445
82MP0005647_abnormal_sex_gland0.87359875
83MP0001963_abnormal_hearing_physiology0.85848504
84MP0006082_CNS_inflammation0.83804831
85MP0000653_abnormal_sex_gland0.83120904
86MP0001970_abnormal_pain_threshold0.82269662
87MP0003121_genomic_imprinting0.81456152
88MP0002938_white_spotting0.80732005
89MP0009379_abnormal_foot_pigmentation0.80694278
90MP0002272_abnormal_nervous_system0.80552898
91MP0008775_abnormal_heart_ventricle0.79158819
92MP0008961_abnormal_basal_metabolism0.77888284
93MP0003136_yellow_coat_color0.75924734
94MP0005195_abnormal_posterior_eye0.75779048
95MP0005408_hypopigmentation0.72350570
96MP0003122_maternal_imprinting0.72317636
97MP0001765_abnormal_ion_homeostasis0.72193742
98MP0003878_abnormal_ear_physiology0.71961449
99MP0005377_hearing/vestibular/ear_phenot0.71961449
100MP0002733_abnormal_thermal_nociception0.71639905

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.17667688
2Acute necrotizing encephalopathy (HP:0006965)5.15403674
3Abnormal mitochondria in muscle tissue (HP:0008316)4.77915108
4Mitochondrial inheritance (HP:0001427)4.71730853
5Acute encephalopathy (HP:0006846)4.62173047
6Progressive macrocephaly (HP:0004481)4.48423292
7Hepatocellular necrosis (HP:0001404)4.25272170
8Increased CSF lactate (HP:0002490)4.21281729
93-Methylglutaconic aciduria (HP:0003535)4.08621394
10Thyroid-stimulating hormone excess (HP:0002925)4.07985866
11Hepatic necrosis (HP:0002605)3.77943111
12Cerebral edema (HP:0002181)3.46182329
13Hyperglycinuria (HP:0003108)3.28800285
14Congenital stationary night blindness (HP:0007642)3.15546892
15Abnormality of serine family amino acid metabolism (HP:0010894)3.15325523
16Abnormality of glycine metabolism (HP:0010895)3.15325523
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.13492511
18Abnormality of alanine metabolism (HP:0010916)3.13492511
19Hyperalaninemia (HP:0003348)3.13492511
20Pancreatic cysts (HP:0001737)3.08594142
21Lactic acidosis (HP:0003128)3.05888159
22Increased hepatocellular lipid droplets (HP:0006565)2.99074614
23Lipid accumulation in hepatocytes (HP:0006561)2.92058929
24Respiratory failure (HP:0002878)2.84867847
25Microretrognathia (HP:0000308)2.83963379
26Decreased central vision (HP:0007663)2.78101884
27Increased serum lactate (HP:0002151)2.76238082
28Hypoproteinemia (HP:0003075)2.74869910
29Optic disc pallor (HP:0000543)2.71328873
30Cerebellar dysplasia (HP:0007033)2.67400115
31Hypoplasia of the uterus (HP:0000013)2.66551285
32Aplasia/hypoplasia of the uterus (HP:0008684)2.63013839
33Limb dystonia (HP:0002451)2.62980674
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56704422
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56704422
36Hyperglycinemia (HP:0002154)2.54789585
37Pancreatic fibrosis (HP:0100732)2.53834035
38True hermaphroditism (HP:0010459)2.51652529
39Increased intramyocellular lipid droplets (HP:0012240)2.51147921
40CNS demyelination (HP:0007305)2.50468817
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.49691136
42Short tibia (HP:0005736)2.47143620
43Leukodystrophy (HP:0002415)2.41332309
44Type II lissencephaly (HP:0007260)2.41224164
45Degeneration of anterior horn cells (HP:0002398)2.41066612
46Abnormality of the anterior horn cell (HP:0006802)2.41066612
47Hypothermia (HP:0002045)2.40148800
48Methylmalonic acidemia (HP:0002912)2.40125364
49Nephrogenic diabetes insipidus (HP:0009806)2.37992332
50Medial flaring of the eyebrow (HP:0010747)2.35132149
51Congenital, generalized hypertrichosis (HP:0004540)2.29641805
52Exercise intolerance (HP:0003546)2.27756933
53Lethargy (HP:0001254)2.27181098
54Renal Fanconi syndrome (HP:0001994)2.22789499
55Attenuation of retinal blood vessels (HP:0007843)2.21902286
56Abnormality of serum amino acid levels (HP:0003112)2.21714158
57Pancytopenia (HP:0001876)2.17417147
58Exertional dyspnea (HP:0002875)2.17146790
59Increased muscle lipid content (HP:0009058)2.14714239
60Abnormality of midbrain morphology (HP:0002418)2.14552527
61Molar tooth sign on MRI (HP:0002419)2.14552527
62Congenital primary aphakia (HP:0007707)2.09919790
63Glycosuria (HP:0003076)2.05961900
64Abnormality of urine glucose concentration (HP:0011016)2.05961900
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05027870
66Abolished electroretinogram (ERG) (HP:0000550)2.02870967
67Lissencephaly (HP:0001339)2.01254335
68Atrophy/Degeneration involving motor neurons (HP:0007373)1.99844854
69Severe combined immunodeficiency (HP:0004430)1.98004265
70Methylmalonic aciduria (HP:0012120)1.97710967
71Colon cancer (HP:0003003)1.95225210
72Gait imbalance (HP:0002141)1.95020400
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92156452
74Progressive microcephaly (HP:0000253)1.90135845
75Cerebral hypomyelination (HP:0006808)1.89733372
76Posterior subcapsular cataract (HP:0007787)1.88989853
77Generalized aminoaciduria (HP:0002909)1.87661641
78Type 2 muscle fiber atrophy (HP:0003554)1.84948746
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83622850
80X-linked dominant inheritance (HP:0001423)1.83569275
81Blindness (HP:0000618)1.83373131
82Alveolar cell carcinoma (HP:0006519)1.82201206
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79117315
84Abnormal rod and cone electroretinograms (HP:0008323)1.79028477
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76883542
86Ketoacidosis (HP:0001993)1.75507574
87Pendular nystagmus (HP:0012043)1.73800555
88Chronic bronchitis (HP:0004469)1.71982640
89Metabolic acidosis (HP:0001942)1.70502022
90Sclerocornea (HP:0000647)1.70411349
91Renal cortical cysts (HP:0000803)1.69277366
92Unsteady gait (HP:0002317)1.68625442
93Dicarboxylic aciduria (HP:0003215)1.68051841
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68051841
95Ketosis (HP:0001946)1.67174230
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64948683
97Anencephaly (HP:0002323)1.64028725
98Emotional lability (HP:0000712)1.62917815
99Chorioretinal atrophy (HP:0000533)1.61743419
100Cystic liver disease (HP:0006706)1.60468550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.66434244
2TXK3.51976277
3CDK193.36422459
4KDR3.10279987
5TAOK32.89896034
6EIF2AK32.82269737
7BUB12.72675525
8STK162.62719528
9PLK42.42064456
10OXSR12.20937419
11FRK2.16948837
12ADRBK22.10352747
13MAP4K22.07726979
14MKNK22.03094681
15TLK12.01655608
16ERBB31.99956384
17STK391.80348806
18ZAK1.79949290
19GRK11.75513451
20VRK11.75459765
21BMPR21.66490518
22BCR1.59923435
23RPS6KA51.44216869
24TRIM281.41144759
25MKNK11.38561754
26CSNK1G31.36481915
27CSNK1A1L1.31606722
28MST41.27885311
29PINK11.25821567
30WNK31.25686033
31LATS11.17089624
32CSNK1G11.13758060
33TESK21.08047361
34EIF2AK11.05476865
35STK31.02482601
36TYRO30.98194925
37BMPR1B0.98098798
38MAPK130.98033225
39INSRR0.97111012
40CSNK1G20.95788477
41TNK20.92494105
42PLK20.90267335
43BCKDK0.87380917
44FES0.87268454
45EPHA40.85790214
46LIMK10.84913925
47PIM20.82702659
48VRK20.82194653
49SIK20.81877099
50TRPM70.81407129
51PASK0.81346539
52CSNK1A10.75584604
53ITK0.74622067
54SRPK10.74351765
55EIF2AK20.71166378
56NEK10.67933045
57CHUK0.66609960
58RPS6KA40.65966480
59CSF1R0.61897230
60ACVR1B0.60502382
61MYLK0.59950393
62LCK0.59605606
63ILK0.59299969
64PLK30.58200711
65PRKCG0.56543557
66TEC0.55877912
67WNK40.55532674
68LYN0.54429101
69OBSCN0.54041308
70MAP3K120.51904870
71CAMKK20.51535776
72AURKB0.51246831
73MAP2K70.51119963
74MINK10.50906883
75CSNK2A10.50286582
76ADRBK10.49522267
77NEK20.48729435
78CSK0.48101110
79CSNK2A20.47409818
80MARK30.46512927
81DYRK20.45092491
82IGF1R0.42976731
83MAP3K60.42809021
84DYRK30.41433718
85BTK0.40446705
86RAF10.40139033
87ABL10.39466125
88CAMK2A0.39239411
89MAPKAPK30.38614047
90PRKACA0.37200911
91PRKCA0.36382468
92PRKCE0.35839380
93CASK0.35391895
94FLT30.32274175
95ROCK10.31634845
96SIK30.31221083
97BRSK10.30300989
98KIT0.29172120
99PBK0.28744128
100CDC70.28669122

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.58550964
2Asthma_Homo sapiens_hsa053103.52067738
3Proteasome_Homo sapiens_hsa030503.40746292
4Parkinsons disease_Homo sapiens_hsa050122.96676282
5Autoimmune thyroid disease_Homo sapiens_hsa053202.78002723
6RNA polymerase_Homo sapiens_hsa030202.77795286
7Graft-versus-host disease_Homo sapiens_hsa053322.66063752
8Allograft rejection_Homo sapiens_hsa053302.61773343
9Type I diabetes mellitus_Homo sapiens_hsa049402.32806211
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.08394626
11Propanoate metabolism_Homo sapiens_hsa006401.96346155
12Sulfur metabolism_Homo sapiens_hsa009201.94852185
13One carbon pool by folate_Homo sapiens_hsa006701.94152823
14Huntingtons disease_Homo sapiens_hsa050161.92586764
15Protein export_Homo sapiens_hsa030601.89956762
16Ribosome_Homo sapiens_hsa030101.86147783
17Alzheimers disease_Homo sapiens_hsa050101.79747367
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75183727
19Viral myocarditis_Homo sapiens_hsa054161.66177315
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64536613
21Systemic lupus erythematosus_Homo sapiens_hsa053221.62774118
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57715894
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57286002
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51350221
25Basal transcription factors_Homo sapiens_hsa030221.51312000
26Antigen processing and presentation_Homo sapiens_hsa046121.43719400
27Rheumatoid arthritis_Homo sapiens_hsa053231.40809284
28Nitrogen metabolism_Homo sapiens_hsa009101.39008942
29Phototransduction_Homo sapiens_hsa047441.37429201
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33434430
31Butanoate metabolism_Homo sapiens_hsa006501.30561597
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30028710
33Fatty acid elongation_Homo sapiens_hsa000621.27266522
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25380821
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.21650914
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.17974364
37Cardiac muscle contraction_Homo sapiens_hsa042601.10405801
38Staphylococcus aureus infection_Homo sapiens_hsa051501.09703917
39RNA degradation_Homo sapiens_hsa030181.09451985
40Peroxisome_Homo sapiens_hsa041461.09211276
41Mismatch repair_Homo sapiens_hsa034301.08721759
42Collecting duct acid secretion_Homo sapiens_hsa049661.08097262
43RNA transport_Homo sapiens_hsa030131.06257745
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00846119
45Pyrimidine metabolism_Homo sapiens_hsa002401.00845579
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00741544
47Tryptophan metabolism_Homo sapiens_hsa003800.96329746
48Primary immunodeficiency_Homo sapiens_hsa053400.94411991
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92959284
50Spliceosome_Homo sapiens_hsa030400.91445963
51beta-Alanine metabolism_Homo sapiens_hsa004100.89073540
52Homologous recombination_Homo sapiens_hsa034400.88650782
53Purine metabolism_Homo sapiens_hsa002300.84776631
54Fanconi anemia pathway_Homo sapiens_hsa034600.84560606
55Fatty acid metabolism_Homo sapiens_hsa012120.84005780
56Regulation of autophagy_Homo sapiens_hsa041400.77903733
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74338910
58Pyruvate metabolism_Homo sapiens_hsa006200.73526194
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69969627
60Chemical carcinogenesis_Homo sapiens_hsa052040.69149152
61Fatty acid degradation_Homo sapiens_hsa000710.68800167
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67463091
63Metabolic pathways_Homo sapiens_hsa011000.66332427
64Linoleic acid metabolism_Homo sapiens_hsa005910.64201619
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.63880725
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63737474
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63079277
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62875371
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60102288
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57295863
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56336452
72Vitamin B6 metabolism_Homo sapiens_hsa007500.54469463
73Hematopoietic cell lineage_Homo sapiens_hsa046400.53708170
74Leishmaniasis_Homo sapiens_hsa051400.53411705
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53269517
76Arginine and proline metabolism_Homo sapiens_hsa003300.52862642
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52748011
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52628998
79Tyrosine metabolism_Homo sapiens_hsa003500.51656585
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51462230
81Olfactory transduction_Homo sapiens_hsa047400.51302184
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.47596015
83Herpes simplex infection_Homo sapiens_hsa051680.46986253
84Base excision repair_Homo sapiens_hsa034100.46714655
85ABC transporters_Homo sapiens_hsa020100.44313357
86Carbon metabolism_Homo sapiens_hsa012000.43975933
87Sulfur relay system_Homo sapiens_hsa041220.43288209
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.42700295
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42502949
90Phenylalanine metabolism_Homo sapiens_hsa003600.42223870
91Alcoholism_Homo sapiens_hsa050340.41224911
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40950479
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38824475
94Retinol metabolism_Homo sapiens_hsa008300.38650008
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37896367
96Glutathione metabolism_Homo sapiens_hsa004800.37192506
97Non-homologous end-joining_Homo sapiens_hsa034500.36966075
98Selenocompound metabolism_Homo sapiens_hsa004500.36124945
99DNA replication_Homo sapiens_hsa030300.33692374
100Epstein-Barr virus infection_Homo sapiens_hsa051690.29475483

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