SLC25A33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.64093064
2cellular potassium ion homeostasis (GO:0030007)4.47398213
3retinal cone cell development (GO:0046549)4.42762179
4synapsis (GO:0007129)4.25338678
5gamma-aminobutyric acid transport (GO:0015812)4.20555516
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.19585905
7behavioral response to nicotine (GO:0035095)4.17563854
8sodium ion export (GO:0071436)4.16715736
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.15346222
10synaptic vesicle exocytosis (GO:0016079)4.01268083
11synaptic vesicle maturation (GO:0016188)3.98490422
12pseudouridine synthesis (GO:0001522)3.95367870
13piRNA metabolic process (GO:0034587)3.88872150
14regulation of rhodopsin mediated signaling pathway (GO:0022400)3.87841065
15neurotransmitter secretion (GO:0007269)3.84761164
16glutamate secretion (GO:0014047)3.81559453
17male meiosis I (GO:0007141)3.77568898
18rhodopsin mediated signaling pathway (GO:0016056)3.72601489
19kynurenine metabolic process (GO:0070189)3.72018988
20respiratory chain complex IV assembly (GO:0008535)3.70318508
21water-soluble vitamin biosynthetic process (GO:0042364)3.65693193
22neuromuscular process controlling posture (GO:0050884)3.62993170
23maturation of 5.8S rRNA (GO:0000460)3.61066067
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57596688
25replication fork processing (GO:0031297)3.55541638
26mitochondrial respiratory chain complex assembly (GO:0033108)3.53592415
27DNA replication-dependent nucleosome organization (GO:0034723)3.53097012
28DNA replication-dependent nucleosome assembly (GO:0006335)3.53097012
29protein-cofactor linkage (GO:0018065)3.52499267
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.51237433
31NADH dehydrogenase complex assembly (GO:0010257)3.51237433
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51237433
33protein complex biogenesis (GO:0070271)3.47303010
34imidazole-containing compound metabolic process (GO:0052803)3.44179513
35neuronal action potential propagation (GO:0019227)3.39868430
36neurotransmitter transport (GO:0006836)3.38584799
37indole-containing compound catabolic process (GO:0042436)3.37468156
38indolalkylamine catabolic process (GO:0046218)3.37468156
39tryptophan catabolic process (GO:0006569)3.37468156
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36679437
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36669496
42cytochrome complex assembly (GO:0017004)3.35198164
43regulation of synaptic vesicle exocytosis (GO:2000300)3.35180050
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.25069097
45vocalization behavior (GO:0071625)3.22890727
46alanine transport (GO:0032328)3.22629859
47protein localization to synapse (GO:0035418)3.20446711
48DNA methylation involved in gamete generation (GO:0043046)3.20432355
49regulation of hexokinase activity (GO:1903299)3.19771651
50regulation of glucokinase activity (GO:0033131)3.19771651
51photoreceptor cell development (GO:0042461)3.19648127
52cellular sodium ion homeostasis (GO:0006883)3.18744357
53DNA replication checkpoint (GO:0000076)3.17302983
54positive regulation of guanylate cyclase activity (GO:0031284)3.16032970
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15674743
56regulation of neurotransmitter levels (GO:0001505)3.14194593
57cilium or flagellum-dependent cell motility (GO:0001539)3.13234097
58regulation of synaptic vesicle transport (GO:1902803)3.12227609
59C4-dicarboxylate transport (GO:0015740)3.12028774
60tryptophan metabolic process (GO:0006568)3.09735600
61dicarboxylic acid biosynthetic process (GO:0043650)3.09428268
62regulation of mitochondrial translation (GO:0070129)3.09390515
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.08372606
64ubiquinone biosynthetic process (GO:0006744)3.07897310
65translesion synthesis (GO:0019985)3.07487256
66response to histamine (GO:0034776)3.07459530
67CDP-diacylglycerol biosynthetic process (GO:0016024)3.07000964
68CDP-diacylglycerol metabolic process (GO:0046341)3.05896501
69mitochondrial RNA metabolic process (GO:0000959)3.05722117
70locomotory exploration behavior (GO:0035641)3.03954584
71proline transport (GO:0015824)3.03498955
72glutamate metabolic process (GO:0006536)3.03469223
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.02303941
74termination of RNA polymerase III transcription (GO:0006386)3.02303941
75eye photoreceptor cell development (GO:0042462)3.01778864
76reciprocal DNA recombination (GO:0035825)3.01332620
77reciprocal meiotic recombination (GO:0007131)3.01332620
78retinal rod cell development (GO:0046548)2.98495972
79ATP synthesis coupled proton transport (GO:0015986)2.97464620
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97464620
81acrosome reaction (GO:0007340)2.97450928
82DNA deamination (GO:0045006)2.96813371
83mating behavior (GO:0007617)2.95130608
84cell communication by electrical coupling (GO:0010644)2.94228189
85proteasome assembly (GO:0043248)2.94010257
86indolalkylamine metabolic process (GO:0006586)2.93831497
87detection of light stimulus involved in visual perception (GO:0050908)2.93323696
88detection of light stimulus involved in sensory perception (GO:0050962)2.93323696
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91466651
90potassium ion import (GO:0010107)2.90675209
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88494744
92male meiosis (GO:0007140)2.87521915
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.86923946
94tRNA modification (GO:0006400)2.86332966
95potassium ion homeostasis (GO:0055075)2.85255168
96ubiquinone metabolic process (GO:0006743)2.84867108
97fucose catabolic process (GO:0019317)2.84573998
98L-fucose metabolic process (GO:0042354)2.84573998
99L-fucose catabolic process (GO:0042355)2.84573998
100protein-chromophore linkage (GO:0018298)2.84477528
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83213097
102somatic hypermutation of immunoglobulin genes (GO:0016446)2.83213097
103calcium ion-dependent exocytosis (GO:0017156)2.82933049
104meiosis I (GO:0007127)2.81953823
105positive regulation of prostaglandin secretion (GO:0032308)2.81814313
106axonemal dynein complex assembly (GO:0070286)2.81259544
107triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.80045857
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79853426
109regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78632077
110layer formation in cerebral cortex (GO:0021819)2.78171709
111regulation of neuronal synaptic plasticity (GO:0048168)2.76484877
112regulation of voltage-gated calcium channel activity (GO:1901385)2.75052332
113regulation of guanylate cyclase activity (GO:0031282)2.74962563
114regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74846422
115neuron-neuron synaptic transmission (GO:0007270)2.73842226
116protein K6-linked ubiquitination (GO:0085020)2.73626219
117behavioral response to cocaine (GO:0048148)2.73174816
118rRNA modification (GO:0000154)2.73056900
119aspartate family amino acid catabolic process (GO:0009068)2.72279048
120tRNA processing (GO:0008033)2.71898528
121short-term memory (GO:0007614)2.70818095
122aromatic amino acid family catabolic process (GO:0009074)2.70430312
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69470269
124regulation of glutamate receptor signaling pathway (GO:1900449)2.68718116
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.68321943
126L-phenylalanine metabolic process (GO:0006558)2.68321943
127ketone body metabolic process (GO:1902224)2.68214429
128ionotropic glutamate receptor signaling pathway (GO:0035235)2.66853416
129cilium movement (GO:0003341)2.66548769
130neurotransmitter-gated ion channel clustering (GO:0072578)2.66188533
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66019038
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64770299
133alpha-linolenic acid metabolic process (GO:0036109)2.64694834
134chromosome organization involved in meiosis (GO:0070192)2.64340978
135intracellular protein transmembrane import (GO:0044743)2.64154618
136response to pheromone (GO:0019236)2.63834141
137regulation of synaptic transmission, dopaminergic (GO:0032225)2.63635526
138amino acid salvage (GO:0043102)2.62902010
139L-methionine salvage (GO:0071267)2.62902010
140L-methionine biosynthetic process (GO:0071265)2.62902010
141membrane depolarization during action potential (GO:0086010)2.62829755
142L-phenylalanine catabolic process (GO:0006559)2.62788274
143erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.62788274
144cysteine metabolic process (GO:0006534)2.62503435
145dicarboxylic acid catabolic process (GO:0043649)2.62207837
146ribosome biogenesis (GO:0042254)2.61975011
147phototransduction (GO:0007602)2.61691637
148synaptic transmission, glutamatergic (GO:0035249)2.60818655
149methionine biosynthetic process (GO:0009086)2.60584645
150positive regulation of sodium ion transmembrane transport (GO:1902307)2.60358562
151fear response (GO:0042596)2.60162370
152regulation of clathrin-mediated endocytosis (GO:2000369)2.58809118
153sperm motility (GO:0030317)2.58322430
154long-term memory (GO:0007616)2.58240545
155double-strand break repair via homologous recombination (GO:0000724)2.57383870
156recombinational repair (GO:0000725)2.57380499
157meiotic chromosome segregation (GO:0045132)2.56960338
158positive regulation of cGMP biosynthetic process (GO:0030828)2.56478645
159behavioral fear response (GO:0001662)2.56477779
160behavioral defense response (GO:0002209)2.56477779
161positive regulation of neurotransmitter transport (GO:0051590)2.56124124
162activation of protein kinase A activity (GO:0034199)2.56107114
163regulation of sodium ion transmembrane transporter activity (GO:2000649)2.55351485
164electron transport chain (GO:0022900)2.55198556
165chromatin remodeling at centromere (GO:0031055)2.55174189
166glutamate receptor signaling pathway (GO:0007215)2.54955000
167peptidyl-histidine modification (GO:0018202)2.54064514
168resolution of meiotic recombination intermediates (GO:0000712)2.54063324
169neurotransmitter uptake (GO:0001504)2.53376527
170acrosome assembly (GO:0001675)2.53207610
171transcription elongation from RNA polymerase I promoter (GO:0006362)2.52942003
172detection of light stimulus (GO:0009583)2.52577270
173lysine catabolic process (GO:0006554)2.52293142
174lysine metabolic process (GO:0006553)2.52293142
175striatum development (GO:0021756)2.52066392
176regulation of meiosis I (GO:0060631)2.51303061
177postreplication repair (GO:0006301)2.50367669
178positive regulation of synapse maturation (GO:0090129)2.49906876
179negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49802751
180respiratory electron transport chain (GO:0022904)2.49101209
181quinone biosynthetic process (GO:1901663)2.47692711
182regulation of vesicle fusion (GO:0031338)2.47433252
183membrane hyperpolarization (GO:0060081)2.46995467
184mannosylation (GO:0097502)2.46311677
185cellular ketone body metabolic process (GO:0046950)2.46179196
186termination of RNA polymerase I transcription (GO:0006363)2.44971708
187RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44573901
188regulation of prostaglandin secretion (GO:0032306)2.43671447
189glycerophospholipid catabolic process (GO:0046475)2.43014323
190rRNA processing (GO:0006364)2.42929061
191exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.41947910
192tRNA metabolic process (GO:0006399)2.41767774
193cellular biogenic amine biosynthetic process (GO:0042401)2.41159768
194rRNA metabolic process (GO:0016072)2.39780642
195nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38725861
196regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.35909711
197regulation of mitotic spindle checkpoint (GO:1903504)2.35909711
198amine biosynthetic process (GO:0009309)2.33724644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.18301371
2EZH2_22144423_ChIP-Seq_EOC_Human4.83637785
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83215145
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.61812670
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.45469220
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16495154
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14379020
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00776699
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.95064650
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.93106002
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.92468522
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.90502438
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.68823461
14E2F7_22180533_ChIP-Seq_HELA_Human2.54010530
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.39851618
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.32140106
17VDR_23849224_ChIP-Seq_CD4+_Human2.31467322
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30187681
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.30161945
20MYC_18940864_ChIP-ChIP_HL60_Human2.29312941
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18456604
22IRF1_19129219_ChIP-ChIP_H3396_Human2.11062912
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10250415
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.09628938
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.09310618
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08219000
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06210279
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03551910
29MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00497992
30IGF1R_20145208_ChIP-Seq_DFB_Human1.97314327
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94779347
32FOXP3_21729870_ChIP-Seq_TREG_Human1.93407865
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93376008
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.93087781
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92115948
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86770503
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85544512
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84866898
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82769612
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82205426
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82205426
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81413386
43ELK1_19687146_ChIP-ChIP_HELA_Human1.79842734
44ZNF263_19887448_ChIP-Seq_K562_Human1.79522381
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77571740
46DROSHA_22980978_ChIP-Seq_HELA_Human1.76749890
47EWS_26573619_Chip-Seq_HEK293_Human1.76643141
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75590192
49DCP1A_22483619_ChIP-Seq_HELA_Human1.74492521
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74435019
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74205533
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.71748764
53TP53_22573176_ChIP-Seq_HFKS_Human1.71277445
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70877314
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.70518216
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69617975
57GABP_19822575_ChIP-Seq_HepG2_Human1.69366096
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69232393
59* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67284032
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.66430192
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65979201
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64781447
63GBX2_23144817_ChIP-Seq_PC3_Human1.64429790
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.64037472
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63515475
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62105043
67* TTF2_22483619_ChIP-Seq_HELA_Human1.56672219
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.56600246
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56219752
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55833722
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55136372
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54992401
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52349858
74ZNF274_21170338_ChIP-Seq_K562_Hela1.48274165
75AR_21572438_ChIP-Seq_LNCaP_Human1.47913492
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.46409268
77* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45349095
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45307194
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45206339
80FUS_26573619_Chip-Seq_HEK293_Human1.44005063
81VDR_22108803_ChIP-Seq_LS180_Human1.39939611
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.37859475
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36400539
84* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35815640
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.35537983
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35299704
87BCAT_22108803_ChIP-Seq_LS180_Human1.32177437
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31309798
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.30834951
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.28922571
91ER_23166858_ChIP-Seq_MCF-7_Human1.28839032
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28577736
93* KDM5A_27292631_Chip-Seq_BREAST_Human1.26517235
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23283936
95* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23199502
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22454965
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22380374
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22238383
99* XRN2_22483619_ChIP-Seq_HELA_Human1.22230040
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21014231
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.17346632
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17346632
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16255217
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.15718687
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.15605313
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15398835
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15094364
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.14980910
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14655606
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12204743
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12137188
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09874076
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09688282
114SMAD4_21799915_ChIP-Seq_A2780_Human1.08981038
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06895949
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.06781695
117KLF4_19829295_ChIP-Seq_ESCs_Human1.06764170
118CTCF_27219007_Chip-Seq_Bcells_Human1.06384661
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05764886
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05135889
121ERA_21632823_ChIP-Seq_H3396_Human1.04578260
122GATA3_21878914_ChIP-Seq_MCF-7_Human1.03329078
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02770320
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02751395
125* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01909471
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00409816
127* HOXB7_26014856_ChIP-Seq_BT474_Human0.99219495
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98825691
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98541362
130* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98030495
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97706618
132TAF15_26573619_Chip-Seq_HEK293_Human0.97590929
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97503078
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96950496
135* SMC4_20622854_ChIP-Seq_HELA_Human0.96663979
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.95762792
137HTT_18923047_ChIP-ChIP_STHdh_Human0.95753922
138NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95518838
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93731768
140NCOR_22424771_ChIP-Seq_293T_Human0.93658614
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93552824
142MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92679239
143RNF2_27304074_Chip-Seq_NSC_Mouse0.92267374
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92090199
145PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92050738
146SOX2_19829295_ChIP-Seq_ESCs_Human0.91451571
147NANOG_19829295_ChIP-Seq_ESCs_Human0.91451571
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91428650
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91427598
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91233548
151MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90730361
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89629639
153CBP_20019798_ChIP-Seq_JUKART_Human0.89629639
154* KDM2B_26808549_Chip-Seq_K562_Human0.89517516
155MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89354869
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89047381
157AR_20517297_ChIP-Seq_VCAP_Human0.88975083
158AR_19668381_ChIP-Seq_PC3_Human0.88848238
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88105771
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87560251
161* AR_25329375_ChIP-Seq_VCAP_Human0.85955333
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.85754247
163* WDR5_24793694_ChIP-Seq_LNCAP_Human0.85749537
164FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84210720
165NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83261921
166ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82942090
167TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82690751
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82367956
169SOX2_21211035_ChIP-Seq_LN229_Gbm0.82012813
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.81404954
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81338853
172UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80513741
173TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.79162792
174SMAD3_21741376_ChIP-Seq_EPCs_Human0.78495775
175* CREB1_26743006_Chip-Seq_LNCaP_Human0.78006606
176* OCT4_19829295_ChIP-Seq_ESCs_Human0.77967038
177MYC_27129775_Chip-Seq_CORNEA_Mouse0.76667581
178SMAD3_21741376_ChIP-Seq_HESCs_Human0.75465727
179* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75301544
180FLI1_21867929_ChIP-Seq_TH2_Mouse0.74879544
181TAF2_19829295_ChIP-Seq_ESCs_Human0.74774354
182P300_19829295_ChIP-Seq_ESCs_Human0.73909062
183* SA1_27219007_Chip-Seq_Bcells_Human0.72420413
184TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72160050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.86434304
2MP0005551_abnormal_eye_electrophysiolog3.55678858
3MP0008877_abnormal_DNA_methylation3.49322256
4MP0003011_delayed_dark_adaptation3.13703454
5MP0003880_abnormal_central_pattern2.99782723
6MP0003635_abnormal_synaptic_transmissio2.98375009
7MP0002822_catalepsy2.97249515
8MP0003195_calcinosis2.90509145
9MP0004270_analgesia2.89208541
10MP0009046_muscle_twitch2.84316395
11MP0003718_maternal_effect2.79927911
12MP0008058_abnormal_DNA_repair2.76152147
13MP0005410_abnormal_fertilization2.54077784
14MP0009745_abnormal_behavioral_response2.51604753
15MP0002064_seizures2.51087422
16MP0002139_abnormal_hepatobiliary_system2.49585159
17MP0005423_abnormal_somatic_nervous2.34185659
18MP0003646_muscle_fatigue2.27161968
19MP0003329_amyloid_beta_deposits2.26831710
20MP0002063_abnormal_learning/memory/cond2.24605098
21MP0003693_abnormal_embryo_hatching2.22740023
22MP0002272_abnormal_nervous_system2.17664351
23MP0002876_abnormal_thyroid_physiology2.17084829
24MP0001968_abnormal_touch/_nociception2.16577124
25MP0005253_abnormal_eye_physiology2.13871043
26MP0006072_abnormal_retinal_apoptosis2.12362611
27MP0001501_abnormal_sleep_pattern2.07574161
28MP0002572_abnormal_emotion/affect_behav2.06928314
29MP0005360_urolithiasis2.04327610
30MP0001440_abnormal_grooming_behavior2.00336347
31MP0002638_abnormal_pupillary_reflex1.96397131
32MP0001486_abnormal_startle_reflex1.91283297
33MP0004147_increased_porphyrin_level1.89238636
34MP0005646_abnormal_pituitary_gland1.85206654
35MP0002653_abnormal_ependyma_morphology1.81940937
36MP0010094_abnormal_chromosome_stability1.80364442
37MP0006276_abnormal_autonomic_nervous1.78064033
38MP0002734_abnormal_mechanical_nocicepti1.77836064
39MP0005085_abnormal_gallbladder_physiolo1.67194532
40MP0002160_abnormal_reproductive_system1.67054884
41MP0002837_dystrophic_cardiac_calcinosis1.63879277
42MP0009697_abnormal_copulation1.63871392
43MP0002090_abnormal_vision1.60879063
44MP0002210_abnormal_sex_determination1.60571573
45MP0008875_abnormal_xenobiotic_pharmacok1.59891074
46MP0002229_neurodegeneration1.58190287
47MP0001661_extended_life_span1.56971920
48MP0004885_abnormal_endolymph1.56737068
49MP0003111_abnormal_nucleus_morphology1.54892616
50MP0003806_abnormal_nucleotide_metabolis1.54828243
51MP0002733_abnormal_thermal_nociception1.54192585
52MP0002067_abnormal_sensory_capabilities1.51890213
53MP0001984_abnormal_olfaction1.48443307
54MP0005386_behavior/neurological_phenoty1.46362068
55MP0004924_abnormal_behavior1.46362068
56MP0000604_amyloidosis1.45861678
57MP0005365_abnormal_bile_salt1.45822478
58MP0002736_abnormal_nociception_after1.44669293
59MP0002735_abnormal_chemical_nociception1.43293716
60MP0001502_abnormal_circadian_rhythm1.42984166
61MP0002102_abnormal_ear_morphology1.42930712
62MP0000372_irregular_coat_pigmentation1.42642956
63MP0009840_abnormal_foam_cell1.41030163
64MP0001970_abnormal_pain_threshold1.37909466
65MP0008995_early_reproductive_senescence1.37131655
66MP0000751_myopathy1.33547423
67MP0005389_reproductive_system_phenotype1.32676996
68MP0005645_abnormal_hypothalamus_physiol1.31612730
69MP0002882_abnormal_neuron_morphology1.30177478
70MP0005195_abnormal_posterior_eye1.29933238
71MP0001905_abnormal_dopamine_level1.29678495
72MP0003890_abnormal_embryonic-extraembry1.29018736
73MP0005084_abnormal_gallbladder_morpholo1.28809508
74MP0006292_abnormal_olfactory_placode1.27756635
75MP0000569_abnormal_digit_pigmentation1.27278074
76MP0002938_white_spotting1.26844698
77MP0004858_abnormal_nervous_system1.26688592
78MP0010329_abnormal_lipoprotein_level1.25769906
79MP0001986_abnormal_taste_sensitivity1.25197965
80MP0008007_abnormal_cellular_replicative1.23578530
81MP0000653_abnormal_sex_gland1.23396742
82MP0005379_endocrine/exocrine_gland_phen1.22872859
83MP0004142_abnormal_muscle_tone1.22406056
84MP0002909_abnormal_adrenal_gland1.22143430
85MP0001145_abnormal_male_reproductive1.22112523
86MP0005332_abnormal_amino_acid1.21898019
87MP0003786_premature_aging1.21696087
88MP0003186_abnormal_redox_activity1.21420361
89MP0001529_abnormal_vocalization1.20624435
90MP0004043_abnormal_pH_regulation1.20079030
91MP0008057_abnormal_DNA_replication1.19992870
92MP0004130_abnormal_muscle_cell1.19989825
93MP0008569_lethality_at_weaning1.17556989
94MP0004233_abnormal_muscle_weight1.16704730
95MP0008872_abnormal_physiological_respon1.15869755
96MP0005623_abnormal_meninges_morphology1.15493226
97MP0004215_abnormal_myocardial_fiber1.14677457
98MP0002066_abnormal_motor_capabilities/c1.13828786
99MP0005647_abnormal_sex_gland1.13482929
100MP0003633_abnormal_nervous_system1.13304652
101MP0005535_abnormal_body_temperature1.12422310
102MP0002184_abnormal_innervation1.12297298
103MP0003698_abnormal_male_reproductive1.12245967
104MP0003121_genomic_imprinting1.11288465
105MP0002557_abnormal_social/conspecific_i1.10942453
106MP0004811_abnormal_neuron_physiology1.08143896
107MP0005174_abnormal_tail_pigmentation1.06943554
108MP0002752_abnormal_somatic_nervous1.06709261
109MP0008961_abnormal_basal_metabolism1.06527530
110MP0003690_abnormal_glial_cell1.05907235
111MP0000955_abnormal_spinal_cord1.05699921
112MP0003950_abnormal_plasma_membrane1.05487805
113MP0000631_abnormal_neuroendocrine_gland1.04094341
114MP0004133_heterotaxia1.02809536
115MP0001919_abnormal_reproductive_system1.02571993
116MP0006035_abnormal_mitochondrial_morpho1.02146651
117MP0003787_abnormal_imprinting1.01301847
118MP0003634_abnormal_glial_cell0.97599620
119MP0008874_decreased_physiological_sensi0.96470698
120MP0005448_abnormal_energy_balance0.96102536
121MP0003631_nervous_system_phenotype0.94027034
122MP0000747_muscle_weakness0.93869840
123MP0002332_abnormal_exercise_endurance0.93845430
124MP0004145_abnormal_muscle_electrophysio0.92247453
125MP0000427_abnormal_hair_cycle0.90524145
126MP0005584_abnormal_enzyme/coenzyme_acti0.89258934
127MP0001873_stomach_inflammation0.88052543
128MP0002163_abnormal_gland_morphology0.86968015
129MP0006036_abnormal_mitochondrial_physio0.86218881
130MP0001764_abnormal_homeostasis0.85247671
131MP0002152_abnormal_brain_morphology0.84587224
132MP0004036_abnormal_muscle_relaxation0.84366678
133MP0003879_abnormal_hair_cell0.84251009
134MP0005083_abnormal_biliary_tract0.83260719
135MP0001324_abnormal_eye_pigmentation0.83180480
136MP0005167_abnormal_blood-brain_barrier0.82436762
137MP0000778_abnormal_nervous_system0.81980804
138MP0001944_abnormal_pancreas_morphology0.81699646
139MP0003136_yellow_coat_color0.81206137
140MP0002118_abnormal_lipid_homeostasis0.80682457
141MP0005391_vision/eye_phenotype0.79828040
142MP0002161_abnormal_fertility/fecundity0.78428982
143MP0003075_altered_response_to0.77935026
144MP0005266_abnormal_metabolism0.77577261
145MP0001119_abnormal_female_reproductive0.75731980
146MP0003699_abnormal_female_reproductive0.75230878
147MP0003122_maternal_imprinting0.74930934
148MP0002970_abnormal_white_adipose0.74736865
149MP0003252_abnormal_bile_duct0.74243602
150MP0001929_abnormal_gametogenesis0.72259038
151MP0004742_abnormal_vestibular_system0.70493095
152MP0003137_abnormal_impulse_conducting0.70302702
153MP0004484_altered_response_of0.70136459

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.69962352
2Congenital stationary night blindness (HP:0007642)4.64647296
3Focal motor seizures (HP:0011153)4.59548056
4Dyschromatopsia (HP:0007641)4.50642362
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.23170728
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.01695868
7Abnormality of alanine metabolism (HP:0010916)4.01695868
8Hyperalaninemia (HP:0003348)4.01695868
9Central scotoma (HP:0000603)4.01365355
10Bony spicule pigmentary retinopathy (HP:0007737)3.93124462
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.72245978
12Abnormality of macular pigmentation (HP:0008002)3.61120459
13Scotoma (HP:0000575)3.59197099
14Visual hallucinations (HP:0002367)3.56587056
15Absent/shortened dynein arms (HP:0200106)3.56319520
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.56319520
17Abnormal rod and cone electroretinograms (HP:0008323)3.51703027
18Abnormal respiratory motile cilium physiology (HP:0012261)3.49416666
19Abnormal ciliary motility (HP:0012262)3.30623440
20Focal seizures (HP:0007359)3.27155889
21Type II lissencephaly (HP:0007260)3.23989099
22Decreased central vision (HP:0007663)3.19846766
23Birth length less than 3rd percentile (HP:0003561)3.18284823
24Increased CSF lactate (HP:0002490)3.16384810
25Chorioretinal atrophy (HP:0000533)3.16195278
26Pigmentary retinal degeneration (HP:0001146)3.10162076
27Abnormality of midbrain morphology (HP:0002418)3.08277152
28Molar tooth sign on MRI (HP:0002419)3.08277152
29Vitreoretinal degeneration (HP:0000655)3.03945289
30Lipid accumulation in hepatocytes (HP:0006561)2.98780380
31Abnormality of the pons (HP:0007361)2.98526348
32Mitochondrial inheritance (HP:0001427)2.97325242
33Hypoplasia of the pons (HP:0012110)2.93068186
34Abolished electroretinogram (ERG) (HP:0000550)2.84470085
35Rhinitis (HP:0012384)2.82242847
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80840942
37Increased hepatocellular lipid droplets (HP:0006565)2.79577327
38Increased serum lactate (HP:0002151)2.77724933
39Status epilepticus (HP:0002133)2.75062279
40Pancreatic cysts (HP:0001737)2.74142081
41Dysdiadochokinesis (HP:0002075)2.73939050
42Epileptic encephalopathy (HP:0200134)2.72686266
43Generalized tonic-clonic seizures (HP:0002069)2.70584245
44Abnormal respiratory epithelium morphology (HP:0012253)2.66485672
45Abnormal respiratory motile cilium morphology (HP:0005938)2.66485672
46Progressive cerebellar ataxia (HP:0002073)2.64281379
47Progressive macrocephaly (HP:0004481)2.61284999
48Hepatic necrosis (HP:0002605)2.58263881
49Chromsome breakage (HP:0040012)2.57186813
50Supranuclear gaze palsy (HP:0000605)2.53295639
51Absence seizures (HP:0002121)2.53101874
52Posterior subcapsular cataract (HP:0007787)2.52057956
53Hepatocellular necrosis (HP:0001404)2.50639168
54Renal Fanconi syndrome (HP:0001994)2.49334478
55Nephronophthisis (HP:0000090)2.47617620
56Pancreatic fibrosis (HP:0100732)2.44944018
57Atonic seizures (HP:0010819)2.44434611
58Impaired vibration sensation in the lower limbs (HP:0002166)2.43801330
59Attenuation of retinal blood vessels (HP:0007843)2.42555669
60Macular degeneration (HP:0000608)2.40332989
61Pheochromocytoma (HP:0002666)2.40146792
62True hermaphroditism (HP:0010459)2.39419225
63Optic disc pallor (HP:0000543)2.36373740
64Lactic acidosis (HP:0003128)2.35673131
65Abnormality of the lower motor neuron (HP:0002366)2.34956795
66Abnormal number of erythroid precursors (HP:0012131)2.34880248
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34733932
68Hemiplegia (HP:0002301)2.30976859
69Dialeptic seizures (HP:0011146)2.30264069
703-Methylglutaconic aciduria (HP:0003535)2.29783959
71Choroideremia (HP:0001139)2.29763905
72Hypoalphalipoproteinemia (HP:0003233)2.29612343
73Azoospermia (HP:0000027)2.28218391
74Neurofibrillary tangles (HP:0002185)2.27928480
75Action tremor (HP:0002345)2.26759454
76Retinal atrophy (HP:0001105)2.26376703
77Cerebral inclusion bodies (HP:0100314)2.25160847
78Large for gestational age (HP:0001520)2.24824257
79Back pain (HP:0003418)2.23992603
80Abnormality of serum amino acid levels (HP:0003112)2.23841796
81Inability to walk (HP:0002540)2.23830264
82Postural instability (HP:0002172)2.23332510
83Pendular nystagmus (HP:0012043)2.22701488
84Hyperlipoproteinemia (HP:0010980)2.21523990
85Type II diabetes mellitus (HP:0005978)2.20900575
86Tetraplegia (HP:0002445)2.20508595
87Hemiparesis (HP:0001269)2.20487855
88Depression (HP:0000716)2.20357214
89Aplasia/Hypoplasia of the uvula (HP:0010293)2.20056668
90Photophobia (HP:0000613)2.19857186
91Urinary urgency (HP:0000012)2.18887956
92Xanthomatosis (HP:0000991)2.18843919
93Cone-rod dystrophy (HP:0000548)2.18572918
94Febrile seizures (HP:0002373)2.17199527
95Intrahepatic cholestasis (HP:0001406)2.16965569
96Ketosis (HP:0001946)2.15604049
97Bile duct proliferation (HP:0001408)2.15201184
98Abnormal biliary tract physiology (HP:0012439)2.15201184
99Generalized aminoaciduria (HP:0002909)2.14634145
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14000596
101Delusions (HP:0000746)2.13827645
102Retinitis pigmentosa (HP:0000510)2.13780583
103Cholecystitis (HP:0001082)2.13004143
104Abnormal gallbladder physiology (HP:0012438)2.13004143
105Hyperglycinemia (HP:0002154)2.12659910
106Dysmetria (HP:0001310)2.12075687
107Cerebellar dysplasia (HP:0007033)2.11976613
108Abnormality of binocular vision (HP:0011514)2.11324580
109Diplopia (HP:0000651)2.11324580
110Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11040283
111Global brain atrophy (HP:0002283)2.09820680
112Neuroendocrine neoplasm (HP:0100634)2.06290562
113Meckel diverticulum (HP:0002245)2.06277182
114Hypolipoproteinemia (HP:0010981)2.06048475
115Lissencephaly (HP:0001339)2.05715808
116Deep venous thrombosis (HP:0002625)2.04252127
117Hyperammonemia (HP:0001987)2.02622866
118Hyperglycinuria (HP:0003108)2.01727032
119Abnormality of the labia minora (HP:0012880)2.01140862
120Abnormality of the ileum (HP:0001549)2.00104719
121Hypobetalipoproteinemia (HP:0003563)2.00076714
122Abnormality of the renal cortex (HP:0011035)1.99623588
123Severe visual impairment (HP:0001141)1.99151310
124Sclerocornea (HP:0000647)1.98908580
125Exercise-induced myalgia (HP:0003738)1.97119674
126Abnormality of cells of the erythroid lineage (HP:0012130)1.96939702
127Truncal ataxia (HP:0002078)1.96839090
128Lethargy (HP:0001254)1.96561659
129Duplicated collecting system (HP:0000081)1.96530659
130Cerebral edema (HP:0002181)1.95600990
131Absent thumb (HP:0009777)1.94855630
132Abnormality of glycine metabolism (HP:0010895)1.94776314
133Abnormality of serine family amino acid metabolism (HP:0010894)1.94776314
134Abnormality of urine glucose concentration (HP:0011016)1.93867155
135Glycosuria (HP:0003076)1.93867155
136Abnormal drinking behavior (HP:0030082)1.93218957
137Polydipsia (HP:0001959)1.93218957
138Urinary bladder sphincter dysfunction (HP:0002839)1.92906607
139Abnormality of the Achilles tendon (HP:0005109)1.92627995
140Increased intramyocellular lipid droplets (HP:0012240)1.91717600
141Acute encephalopathy (HP:0006846)1.91631733
142Anxiety (HP:0000739)1.90751746
143Athetosis (HP:0002305)1.90399662
144Severe muscular hypotonia (HP:0006829)1.89091074
145Abnormality of the renal medulla (HP:0100957)1.88804364
146Termporal pattern (HP:0011008)1.88432875
147Insidious onset (HP:0003587)1.88432875
148Abnormality of the renal collecting system (HP:0004742)1.88376124
149Progressive inability to walk (HP:0002505)1.87553261
150Confusion (HP:0001289)1.87213761
151Patellar aplasia (HP:0006443)1.86684985
152Abnormal mitochondria in muscle tissue (HP:0008316)1.85999392
153Ketoacidosis (HP:0001993)1.84864902
154Acute necrotizing encephalopathy (HP:0006965)1.82951497
155Myoglobinuria (HP:0002913)1.82596765
156Aplastic anemia (HP:0001915)1.82488072
157Infertility (HP:0000789)1.82455162
158Congenital, generalized hypertrichosis (HP:0004540)1.81701662
159Brushfield spots (HP:0001088)1.81621582
160Increased muscle lipid content (HP:0009058)1.80437140
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.79893601
162Aplasia/Hypoplasia of the patella (HP:0006498)1.79622775
163Mesangial abnormality (HP:0001966)1.79402466
164Concave nail (HP:0001598)1.78069135
165Retinal dysplasia (HP:0007973)1.77297780
166Abnormal glycosylation (HP:0012345)1.76710537
167Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76710537
168Abnormal protein N-linked glycosylation (HP:0012347)1.76710537
169Abnormal protein glycosylation (HP:0012346)1.76710537
170Limb dystonia (HP:0002451)1.72935210
171Abnormal spermatogenesis (HP:0008669)1.72559742
172Prolonged partial thromboplastin time (HP:0003645)1.72140313
173Type I transferrin isoform profile (HP:0003642)1.72014344
174Reticulocytopenia (HP:0001896)1.70284542
175Renal cortical cysts (HP:0000803)1.70215996
176Testicular atrophy (HP:0000029)1.69440296
177CNS demyelination (HP:0007305)1.69248116
178Impulsivity (HP:0100710)1.68861251
179Microretrognathia (HP:0000308)1.68781219
180Progressive microcephaly (HP:0000253)1.64822260
181Abnormality of renal resorption (HP:0011038)1.62776196
182Medial flaring of the eyebrow (HP:0010747)1.61070946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.87808129
2PNCK3.83888420
3FRK3.47313937
4TLK13.32422602
5EPHA43.31938460
6NTRK33.22061245
7MAP3K93.08062915
8MAP3K43.07359779
9BMPR1B2.78773790
10ADRBK22.69515922
11MINK12.62988699
12PINK12.55915318
13TRIM282.41504319
14PDK42.41390492
15PDK32.41390492
16TSSK62.36763695
17MAP2K42.36206976
18KSR22.35160047
19PAK62.24240131
20PRKD32.12384895
21MAP2K72.05402637
22WEE12.01502348
23VRK11.87958266
24MKNK21.86358584
25NTRK21.86309477
26LMTK21.84214317
27MAP4K21.80620375
28ACVR1B1.74166087
29PHKG21.70969020
30PHKG11.70969020
31CAMKK11.70226334
32STK161.64202532
33BUB11.59989778
34TAOK11.56566851
35KSR11.56265682
36PDK21.55959978
37STK381.55885223
38ARAF1.55661894
39MARK11.54598512
40BCKDK1.52819134
41PRKCG1.52355748
42NUAK11.49530469
43GRK11.47575352
44BRSK21.45903692
45NTRK11.39625070
46VRK21.38678744
47MAPKAPK51.36061015
48CDC71.35401542
49EIF2AK31.34022406
50OXSR11.33034949
51MAP3K131.29088877
52TAF11.25630445
53CSNK1G11.23842204
54CAMK1D1.21938298
55GRK51.21391499
56TAOK31.19825524
57NEK11.18813218
58CDK51.18090243
59LATS21.15892627
60RPS6KA51.15775965
61MAPK131.15457410
62CAMKK21.14713148
63TRIB31.14249608
64CHEK21.12988454
65DAPK21.12707048
66NME11.11648393
67MAPK151.09457160
68CSNK1A1L1.09426185
69PLK31.08688923
70PBK1.08482322
71MKNK11.05747436
72SCYL21.04123673
73INSRR1.01087281
74CAMK2A1.01028878
75FES1.00862733
76RIPK40.99749648
77CDK80.99664303
78PRKCI0.98873857
79ATR0.98419378
80CAMK2G0.97377533
81IRAK30.93160263
82PTK2B0.92372324
83TGFBR10.90754858
84DYRK20.90350111
85WNK40.89580264
86TTK0.88251770
87PLK40.87964932
88PLK10.87296287
89CSNK1G20.85134414
90MAP2K10.83438242
91TYRO30.81794365
92STK110.81163641
93MAPK120.81083368
94ICK0.80566506
95PLK20.76901352
96PDK10.76379191
97CDK140.75409618
98PDPK10.75313419
99RAF10.74370332
100CASK0.74243381
101PRKCZ0.71980054
102STK390.71319187
103UHMK10.70955056
104MAP3K10.70288820
105SGK2230.70263973
106SGK4940.70263973
107CDK150.70163673
108STK38L0.69449310
109CDK180.68664771
110MAP2K20.66312012
111EIF2AK20.64706044
112PIM20.64512464
113ALK0.63350213
114RET0.63035440
115EIF2AK10.63027542
116CDK190.61626796
117DYRK1A0.60915870
118MAP3K110.59218191
119TNIK0.58308170
120CDK11A0.58049921
121CAMK2B0.57676549
122BRSK10.57231215
123MAP3K20.56859713
124MST40.54333955
125IRAK20.53859354
126CSNK1E0.53568761
127PRKACG0.53107064
128MAPK100.53038797
129CAMK2D0.52759772
130WNK10.52357727
131RPS6KA30.51605685
132AURKA0.50649465
133PAK30.50331680
134SRPK10.49203008
135DAPK10.48967507
136ATM0.47816199
137CSNK1G30.47636472
138PKN10.46871643
139CDK30.46166593
140ABL20.45966469
141MAP3K50.45522333
142FGR0.45396122
143SGK30.45288865
144PRKCE0.44927883
145MAPKAPK30.43541874
146CSNK2A10.43181685
147ERBB40.43119273
148WNK30.42690368
149CAMK1G0.42272341
150ROCK20.40810548
151DYRK30.40450525
152PRKAA10.40133228
153ADRBK10.39439088
154STK30.39007704
155FER0.38986369
156CHUK0.38894097
157PRKACA0.38748766
158CAMK10.38249409
159IKBKB0.38117202
160MAP2K60.38012738
161PRKG20.37736840
162PIM10.37016219
163CHEK10.36862988
164PASK0.36796768
165CDK70.36032247
166CSNK1A10.34078827
167CSNK2A20.33676978
168FGFR20.32808742
169CCNB10.31210564
170CSNK1D0.30320446

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.71640600
2Nitrogen metabolism_Homo sapiens_hsa009104.10258499
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79773526
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.54208235
5Selenocompound metabolism_Homo sapiens_hsa004502.53365508
6RNA polymerase_Homo sapiens_hsa030202.49265406
7Synaptic vesicle cycle_Homo sapiens_hsa047212.40963482
8Basal transcription factors_Homo sapiens_hsa030222.23049815
9Nicotine addiction_Homo sapiens_hsa050332.14719234
10One carbon pool by folate_Homo sapiens_hsa006702.13749092
11Arginine biosynthesis_Homo sapiens_hsa002202.09541386
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07093332
13Homologous recombination_Homo sapiens_hsa034402.05230207
14GABAergic synapse_Homo sapiens_hsa047271.97351935
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.91938497
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87109418
17Olfactory transduction_Homo sapiens_hsa047401.83197854
18Ribosome_Homo sapiens_hsa030101.76247866
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74848429
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74824840
21Protein export_Homo sapiens_hsa030601.71279250
22Proteasome_Homo sapiens_hsa030501.70145493
23Fanconi anemia pathway_Homo sapiens_hsa034601.67933382
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67173732
25Caffeine metabolism_Homo sapiens_hsa002321.64414826
26Amphetamine addiction_Homo sapiens_hsa050311.63134869
27Linoleic acid metabolism_Homo sapiens_hsa005911.62833593
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61776621
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59503239
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59318492
31Propanoate metabolism_Homo sapiens_hsa006401.57204350
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.57138761
33Pyruvate metabolism_Homo sapiens_hsa006201.57051326
34Long-term potentiation_Homo sapiens_hsa047201.53697347
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52682941
36Glutamatergic synapse_Homo sapiens_hsa047241.52241759
37Cardiac muscle contraction_Homo sapiens_hsa042601.51611627
38Bile secretion_Homo sapiens_hsa049761.48568136
39Circadian entrainment_Homo sapiens_hsa047131.48404410
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46453245
41Salivary secretion_Homo sapiens_hsa049701.39514450
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39473188
43Dopaminergic synapse_Homo sapiens_hsa047281.38119885
44Steroid biosynthesis_Homo sapiens_hsa001001.38027678
45Fatty acid biosynthesis_Homo sapiens_hsa000611.36366363
46Histidine metabolism_Homo sapiens_hsa003401.35909523
47Fatty acid degradation_Homo sapiens_hsa000711.34552427
48Biosynthesis of amino acids_Homo sapiens_hsa012301.34411225
49RNA degradation_Homo sapiens_hsa030181.34370635
50Oxidative phosphorylation_Homo sapiens_hsa001901.33328083
51Morphine addiction_Homo sapiens_hsa050321.31280129
52Parkinsons disease_Homo sapiens_hsa050121.29514218
53Carbon metabolism_Homo sapiens_hsa012001.28963413
54Butanoate metabolism_Homo sapiens_hsa006501.27821443
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25549907
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23504130
57RNA transport_Homo sapiens_hsa030131.22944449
58Nucleotide excision repair_Homo sapiens_hsa034201.22565965
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20102120
60Fatty acid metabolism_Homo sapiens_hsa012121.19329268
61Insulin secretion_Homo sapiens_hsa049111.17608939
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16253267
63DNA replication_Homo sapiens_hsa030301.16014314
64Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12150851
65Pyrimidine metabolism_Homo sapiens_hsa002401.11712717
66Gastric acid secretion_Homo sapiens_hsa049711.11266263
67PPAR signaling pathway_Homo sapiens_hsa033201.11156417
68Cocaine addiction_Homo sapiens_hsa050301.10257417
69Ether lipid metabolism_Homo sapiens_hsa005651.09108477
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08160665
71Sulfur metabolism_Homo sapiens_hsa009201.03948726
72Mismatch repair_Homo sapiens_hsa034301.03338868
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02772552
74Renin secretion_Homo sapiens_hsa049241.02569573
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02411686
76Cholinergic synapse_Homo sapiens_hsa047251.02149026
77Huntingtons disease_Homo sapiens_hsa050160.98997431
78Alzheimers disease_Homo sapiens_hsa050100.98059268
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.97437004
80Base excision repair_Homo sapiens_hsa034100.93025273
81Purine metabolism_Homo sapiens_hsa002300.92697162
82Chemical carcinogenesis_Homo sapiens_hsa052040.89980370
83Spliceosome_Homo sapiens_hsa030400.89468941
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89433873
85Calcium signaling pathway_Homo sapiens_hsa040200.87913507
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87386394
87Asthma_Homo sapiens_hsa053100.85793125
88Metabolic pathways_Homo sapiens_hsa011000.85681836
89Retinol metabolism_Homo sapiens_hsa008300.85281178
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83989134
91Vitamin B6 metabolism_Homo sapiens_hsa007500.83804765
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.83530039
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.83517477
94Tryptophan metabolism_Homo sapiens_hsa003800.82764587
95Glucagon signaling pathway_Homo sapiens_hsa049220.82375447
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82258627
97Glycerolipid metabolism_Homo sapiens_hsa005610.82115142
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80439022
99Serotonergic synapse_Homo sapiens_hsa047260.79665523
100Taste transduction_Homo sapiens_hsa047420.79335385
101Phenylalanine metabolism_Homo sapiens_hsa003600.78892080
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78430051
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76689101
104Oxytocin signaling pathway_Homo sapiens_hsa049210.75175386
105Folate biosynthesis_Homo sapiens_hsa007900.72953751
106Vitamin digestion and absorption_Homo sapiens_hsa049770.72140340
107Non-homologous end-joining_Homo sapiens_hsa034500.71751864
108Long-term depression_Homo sapiens_hsa047300.70964373
109Complement and coagulation cascades_Homo sapiens_hsa046100.70291896
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69481141
111cAMP signaling pathway_Homo sapiens_hsa040240.66015739
112GnRH signaling pathway_Homo sapiens_hsa049120.65700062
113Arachidonic acid metabolism_Homo sapiens_hsa005900.65600714
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65325268
115Arginine and proline metabolism_Homo sapiens_hsa003300.64169046
116Gap junction_Homo sapiens_hsa045400.63900029
117Collecting duct acid secretion_Homo sapiens_hsa049660.63431381
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.62459467
119Regulation of autophagy_Homo sapiens_hsa041400.61689489
120Tyrosine metabolism_Homo sapiens_hsa003500.60843930
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60586262
122Peroxisome_Homo sapiens_hsa041460.59467946
123Thyroid hormone synthesis_Homo sapiens_hsa049180.59385602
124beta-Alanine metabolism_Homo sapiens_hsa004100.58271011
125Pentose phosphate pathway_Homo sapiens_hsa000300.58154279
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57061754
127Estrogen signaling pathway_Homo sapiens_hsa049150.56059998
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54477978
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52852191
130Prion diseases_Homo sapiens_hsa050200.52519280
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52097214
132Fatty acid elongation_Homo sapiens_hsa000620.51889544
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51760623
134Pancreatic secretion_Homo sapiens_hsa049720.51401006
135Cell cycle_Homo sapiens_hsa041100.50687197
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.50424834
137Dorso-ventral axis formation_Homo sapiens_hsa043200.49447470
138mRNA surveillance pathway_Homo sapiens_hsa030150.49337429
139Systemic lupus erythematosus_Homo sapiens_hsa053220.48916669
140Fat digestion and absorption_Homo sapiens_hsa049750.48119961
141Oocyte meiosis_Homo sapiens_hsa041140.47343103
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47117527
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.43779339
144Sulfur relay system_Homo sapiens_hsa041220.43679117
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43235501
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.42924988
147ABC transporters_Homo sapiens_hsa020100.42782606
148Fructose and mannose metabolism_Homo sapiens_hsa000510.42328442
149Circadian rhythm_Homo sapiens_hsa047100.42265538
150Melanogenesis_Homo sapiens_hsa049160.35583437
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34122723
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.33844896
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.32769646
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31936976

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