SLC25A31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.82499157
2regulation of meiosis I (GO:0060631)9.00727571
3meiotic nuclear division (GO:0007126)8.55085608
4chromosome organization involved in meiosis (GO:0070192)8.55055526
5male meiosis I (GO:0007141)7.81977654
6histone H3-K9 demethylation (GO:0033169)7.27917756
7meiotic chromosome segregation (GO:0045132)6.65121100
8meiosis I (GO:0007127)6.61481663
9gene silencing by RNA (GO:0031047)6.44328544
10meiotic cell cycle process (GO:1903046)6.15972449
11histone H3-K36 demethylation (GO:0070544)6.14122878
12DNA alkylation (GO:0006305)6.08082563
13DNA methylation (GO:0006306)6.08082563
14positive regulation of meiosis (GO:0045836)5.82481734
15reciprocal meiotic recombination (GO:0007131)5.73167420
16reciprocal DNA recombination (GO:0035825)5.73167420
17oogenesis (GO:0048477)5.61172152
18positive regulation of meiotic cell cycle (GO:0051446)5.45277286
19DNA synthesis involved in DNA repair (GO:0000731)5.32213041
20negative regulation of meiosis (GO:0045835)5.31512251
21attachment of spindle microtubules to kinetochore (GO:0008608)5.28623240
22positive regulation of translational initiation (GO:0045948)5.04540170
23positive regulation of cellular response to oxidative stress (GO:1900409)4.94776468
24positive regulation of response to oxidative stress (GO:1902884)4.94776468
25resolution of meiotic recombination intermediates (GO:0000712)4.93702015
26sister chromatid cohesion (GO:0007062)4.89607273
27nuclear pore complex assembly (GO:0051292)4.77545271
28nuclear pore organization (GO:0006999)4.77484448
29oocyte maturation (GO:0001556)4.75788425
30DNA replication checkpoint (GO:0000076)4.71160327
31female gamete generation (GO:0007292)4.69352521
32DNA methylation or demethylation (GO:0044728)4.69186699
33gene silencing (GO:0016458)4.51423630
34mitotic chromosome condensation (GO:0007076)4.40394743
35regulation of meiosis (GO:0040020)4.39208217
36heterochromatin organization (GO:0070828)4.33342226
37kinetochore organization (GO:0051383)4.32561486
38regulation of DNA endoreduplication (GO:0032875)4.29258557
39meiotic cell cycle (GO:0051321)4.27095375
40negative regulation of gene silencing (GO:0060969)4.20004298
41synapsis (GO:0007129)4.15184322
42oocyte development (GO:0048599)4.13781909
43kinetochore assembly (GO:0051382)4.06863314
44chromatin remodeling at centromere (GO:0031055)4.04665524
45regulation of double-strand break repair via homologous recombination (GO:0010569)4.00062025
46DNA modification (GO:0006304)3.96262803
47protein K6-linked ubiquitination (GO:0085020)3.94982275
48regulation of transcription from RNA polymerase I promoter (GO:0006356)3.91864316
49proteasome assembly (GO:0043248)3.89977919
50histone exchange (GO:0043486)3.87481828
51DNA replication-dependent nucleosome organization (GO:0034723)3.85631204
52DNA replication-dependent nucleosome assembly (GO:0006335)3.85631204
53negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.77040471
54germ cell development (GO:0007281)3.65300723
55mitotic metaphase plate congression (GO:0007080)3.64717770
56regulation of meiotic cell cycle (GO:0051445)3.54405500
57metaphase plate congression (GO:0051310)3.54370968
58histone lysine demethylation (GO:0070076)3.53967105
59pore complex assembly (GO:0046931)3.49269814
60negative regulation of meiotic cell cycle (GO:0051447)3.48633164
61chromosome organization (GO:0051276)3.48306711
62DNA biosynthetic process (GO:0071897)3.45907874
63histone demethylation (GO:0016577)3.44648671
64embryonic body morphogenesis (GO:0010172)3.44626258
65regulation of histone H3-K9 methylation (GO:0051570)3.43330249
66DNA replication-independent nucleosome organization (GO:0034724)3.43128244
67DNA replication-independent nucleosome assembly (GO:0006336)3.43128244
68male gamete generation (GO:0048232)3.43075773
69nuclear division (GO:0000280)3.42982763
70spermatogenesis (GO:0007283)3.42824884
71regulation of chromosome segregation (GO:0051983)3.39541784
72negative regulation of inclusion body assembly (GO:0090084)3.38901204
73histone H2A acetylation (GO:0043968)3.36419608
74CENP-A containing nucleosome assembly (GO:0034080)3.34894221
75mitotic spindle assembly checkpoint (GO:0007094)3.33629535
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33077670
77mitotic spindle checkpoint (GO:0071174)3.31529052
78sex differentiation (GO:0007548)3.29053907
79negative regulation of chromosome segregation (GO:0051985)3.27974590
80spindle assembly checkpoint (GO:0071173)3.27833298
81gamete generation (GO:0007276)3.27492442
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25707800
83negative regulation of sister chromatid segregation (GO:0033046)3.25707800
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.25707800
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25707800
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24007180
87spindle checkpoint (GO:0031577)3.21656870
88reproductive system development (GO:0061458)3.20125402
89protein dealkylation (GO:0008214)3.18415247
90protein demethylation (GO:0006482)3.18415247
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18140292
92negative regulation of nuclear division (GO:0051784)3.15938067
93organelle fission (GO:0048285)3.14679116
94genitalia morphogenesis (GO:0035112)3.12711032
95regulation of double-strand break repair (GO:2000779)3.12264359
96positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.09613814
97regulation of sister chromatid segregation (GO:0033045)3.08957849
98regulation of mitotic sister chromatid separation (GO:0010965)3.08957849
99regulation of mitotic sister chromatid segregation (GO:0033047)3.08957849
100fertilization (GO:0009566)3.08943210
101DNA packaging (GO:0006323)3.08584785
102monoubiquitinated protein deubiquitination (GO:0035520)3.06587371
103mitotic nuclear envelope disassembly (GO:0007077)3.04540902
104chromosome segregation (GO:0007059)3.04531492
105negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.02501162
106spermatid development (GO:0007286)3.02495875
107histone H4-K16 acetylation (GO:0043984)3.02434005
108mitotic sister chromatid cohesion (GO:0007064)3.01615743
109histone H4-K12 acetylation (GO:0043983)3.01005757
110microtubule depolymerization (GO:0007019)2.99931596
111protein localization to chromosome (GO:0034502)2.99690424
112binding of sperm to zona pellucida (GO:0007339)2.98178961
113regulation of centriole replication (GO:0046599)2.96043766
114chromatin assembly or disassembly (GO:0006333)2.91796003
115body morphogenesis (GO:0010171)2.91005565
116membrane disassembly (GO:0030397)2.90488487
117nuclear envelope disassembly (GO:0051081)2.90488487
118cellular process involved in reproduction in multicellular organism (GO:0022412)2.89832862
119negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.88193892
120mRNA export from nucleus (GO:0006406)2.85878849
121histone H4-K5 acetylation (GO:0043981)2.84020325
122histone H4-K8 acetylation (GO:0043982)2.84020325
123interkinetic nuclear migration (GO:0022027)2.77403871
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.68058289
125regulation of female receptivity (GO:0045924)2.67508119
126protein maturation by protein folding (GO:0022417)2.66916736
127sperm-egg recognition (GO:0035036)2.66884746
128protein refolding (GO:0042026)2.59719584
129piRNA metabolic process (GO:0034587)16.2090756
130DNA methylation involved in gamete generation (GO:0043046)12.7554366
131synaptonemal complex assembly (GO:0007130)12.3809906
132synaptonemal complex organization (GO:0070193)11.5320689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.79920979
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.76253615
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.51902986
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.65549138
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95277562
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54670384
7AR_21909140_ChIP-Seq_LNCAP_Human3.23682037
8IGF1R_20145208_ChIP-Seq_DFB_Human3.20644605
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.12027606
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.09849849
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.98752600
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70254670
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50837454
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.45307715
15MYCN_18555785_ChIP-Seq_MESCs_Mouse2.39635254
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25958567
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23313335
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21968659
19* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21763651
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18944590
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.17164705
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12389658
23ZNF274_21170338_ChIP-Seq_K562_Hela2.02514361
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.01914861
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88633681
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87940181
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84735851
28RNF2_27304074_Chip-Seq_NSC_Mouse1.83547372
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81294887
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.80636413
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78185579
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78185579
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78185579
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78169915
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75079292
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66200175
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.66038987
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61080370
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59581525
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59013814
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57796310
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.56036288
43BCAT_22108803_ChIP-Seq_LS180_Human1.55022231
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53416050
45VDR_23849224_ChIP-Seq_CD4+_Human1.53224685
46DCP1A_22483619_ChIP-Seq_HELA_Human1.53027890
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.49070114
48* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47872423
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47256761
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.47177154
51ER_23166858_ChIP-Seq_MCF-7_Human1.44847630
52XRN2_22483619_ChIP-Seq_HELA_Human1.43870433
53GABP_19822575_ChIP-Seq_HepG2_Human1.40528338
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40246239
55PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39873921
56ERA_21632823_ChIP-Seq_H3396_Human1.37858098
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34481531
58KDM5A_27292631_Chip-Seq_BREAST_Human1.32960028
59* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.29879614
60FOXP3_21729870_ChIP-Seq_TREG_Human1.27749787
61GATA3_26560356_Chip-Seq_TH1_Human1.23056468
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22953323
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22070152
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.21527817
65TTF2_22483619_ChIP-Seq_HELA_Human1.18835910
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16068508
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.14261430
68TP53_22573176_ChIP-Seq_HFKS_Human1.09010358
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06875965
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06803535
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05840748
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02238540
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99762404
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99378395
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96791983
76GATA3_21867929_ChIP-Seq_TH1_Mouse0.96452196
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95021606
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94707683
79FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93733969
80CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92505978
81TAF15_26573619_Chip-Seq_HEK293_Human0.91780901
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91574492
83RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90929677
84* RUNX2_22187159_ChIP-Seq_PCA_Human0.90632015
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90302758
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90013074
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.89865564
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89440144
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89299184
90SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88417892
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88366279
92PHF8_20622854_ChIP-Seq_HELA_Human0.88167999
93SMC4_20622854_ChIP-Seq_HELA_Human0.87387522
94REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87130544
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86032759
96WDR5_24793694_ChIP-Seq_LNCAP_Human0.85781013
97* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85668215
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85639794
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85634801
100E2F1_17053090_ChIP-ChIP_MCF-7_Human0.85068987
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84254419
102YY1_21170310_ChIP-Seq_MESCs_Mouse0.83322764
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83308742
104ELK1_19687146_ChIP-ChIP_HELA_Human0.82594534
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81551452
106* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81184777
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.81137588
108TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81081132
109FUS_26573619_Chip-Seq_HEK293_Human0.80649518
110EWS_26573619_Chip-Seq_HEK293_Human0.80551935
111* MYC_18940864_ChIP-ChIP_HL60_Human0.80143596
112PHF8_20622853_ChIP-Seq_HELA_Human0.79966544
113HTT_18923047_ChIP-ChIP_STHdh_Human0.79076112
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.77869859
115STAT3_23295773_ChIP-Seq_U87_Human0.77299720
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77293294
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77214470
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77129210
119BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.76227231
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76136766
121TFEB_21752829_ChIP-Seq_HELA_Human0.75352260
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75216721
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75100005
124* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.73026058
125LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72367855
126CIITA_25753668_ChIP-Seq_RAJI_Human0.72064862
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71012629
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.69981963
129HOXB7_26014856_ChIP-Seq_BT474_Human0.69229396
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.68233274
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67645462
132FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63354139
133TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.62394887
134ETV1_20927104_ChIP-Seq_GIST48_Human0.62104076
135CDX2_22108803_ChIP-Seq_LS180_Human0.62095929
136OCT4_19829295_ChIP-Seq_ESCs_Human0.60633242
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.60550501
138ELK4_26923725_Chip-Seq_MESODERM_Mouse0.60423454
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.59278183
140HNFA_21074721_ChIP-Seq_CACO-2_Human0.59170462
141RBPJ_21746931_ChIP-Seq_IB4_Human0.58911654
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.58894274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.85858748
2* MP0002210_abnormal_sex_determination4.59359698
3MP0010094_abnormal_chromosome_stability4.14011077
4* MP0001929_abnormal_gametogenesis4.08816463
5MP0003786_premature_aging3.97175746
6MP0008058_abnormal_DNA_repair3.73290647
7* MP0001145_abnormal_male_reproductive3.60961735
8* MP0000653_abnormal_sex_gland3.40588070
9MP0008057_abnormal_DNA_replication3.39493845
10MP0003123_paternal_imprinting3.34599839
11* MP0003698_abnormal_male_reproductive3.20363468
12MP0003111_abnormal_nucleus_morphology3.05816802
13MP0000678_abnormal_parathyroid_gland2.84545227
14MP0003693_abnormal_embryo_hatching2.84079245
15MP0003077_abnormal_cell_cycle2.57943751
16MP0004957_abnormal_blastocyst_morpholog2.50942172
17MP0005410_abnormal_fertilization2.24564540
18MP0008004_abnormal_stomach_pH2.18216078
19* MP0002161_abnormal_fertility/fecundity2.02052529
20MP0008877_abnormal_DNA_methylation11.1547995
21MP0001119_abnormal_female_reproductive1.98401245
22MP0008007_abnormal_cellular_replicative1.87228578
23MP0003718_maternal_effect1.75974780
24MP0008932_abnormal_embryonic_tissue1.72986044
25MP0003121_genomic_imprinting1.70180970
26MP0001730_embryonic_growth_arrest1.63322381
27MP0008789_abnormal_olfactory_epithelium1.55880889
28MP0003699_abnormal_female_reproductive1.53001101
29MP0003890_abnormal_embryonic-extraembry1.39705897
30MP0002160_abnormal_reproductive_system1.39562503
31MP0000350_abnormal_cell_proliferation1.39363497
32MP0004808_abnormal_hematopoietic_stem1.31569065
33MP0003787_abnormal_imprinting1.20671118
34MP0006035_abnormal_mitochondrial_morpho1.19439244
35MP0001188_hyperpigmentation1.17654743
36MP0010352_gastrointestinal_tract_polyps1.17085650
37MP0010307_abnormal_tumor_latency1.16137268
38MP0000015_abnormal_ear_pigmentation1.09078774
39MP0005647_abnormal_sex_gland1.06141170
40MP0005058_abnormal_lysosome_morphology1.06035346
41MP0001697_abnormal_embryo_size1.03511066
42MP0005174_abnormal_tail_pigmentation1.03059197
43MP0003183_abnormal_peptide_metabolism1.01654154
44MP0005380_embryogenesis_phenotype0.98265847
45MP0001672_abnormal_embryogenesis/_devel0.98265847
46MP0002085_abnormal_embryonic_tissue0.97998428
47MP0005394_taste/olfaction_phenotype0.97465037
48MP0005499_abnormal_olfactory_system0.97465037
49MP0005409_darkened_coat_color0.94280803
50MP0003315_abnormal_perineum_morphology0.93418000
51MP0000313_abnormal_cell_death0.91995423
52MP0000013_abnormal_adipose_tissue0.88187558
53MP0005389_reproductive_system_phenotype0.87675460
54MP0002084_abnormal_developmental_patter0.87594851
55MP0009672_abnormal_birth_weight0.86837871
56MP0003984_embryonic_growth_retardation0.85281338
57MP0004197_abnormal_fetal_growth/weight/0.85086123
58MP0009379_abnormal_foot_pigmentation0.84188541
59MP0003878_abnormal_ear_physiology0.83537408
60MP0005377_hearing/vestibular/ear_phenot0.83537408
61MP0002019_abnormal_tumor_incidence0.82998361
62MP0001984_abnormal_olfaction0.82211984
63MP0003646_muscle_fatigue0.79735515
64MP0002088_abnormal_embryonic_growth/wei0.79123362
65MP0002249_abnormal_larynx_morphology0.78279307
66MP0002080_prenatal_lethality0.75734759
67MP0006036_abnormal_mitochondrial_physio0.73507959
68MP0003936_abnormal_reproductive_system0.72168115
69MP0003941_abnormal_skin_development0.72131068
70MP0010030_abnormal_orbit_morphology0.70876612
71MP0001661_extended_life_span0.69996426
72MP0005623_abnormal_meninges_morphology0.68242081
73MP0000358_abnormal_cell_content/0.68008226
74MP0005423_abnormal_somatic_nervous0.67710123
75MP0003943_abnormal_hepatobiliary_system0.66944537
76MP0005395_other_phenotype0.66391969
77MP0005076_abnormal_cell_differentiation0.66021417
78MP0003938_abnormal_ear_development0.65235296
79MP0005451_abnormal_body_composition0.64982616
80MP0002653_abnormal_ependyma_morphology0.64288506
81MP0000427_abnormal_hair_cycle0.63238101
82MP0002086_abnormal_extraembryonic_tissu0.62015305
83MP0003937_abnormal_limbs/digits/tail_de0.58889494
84MP0001915_intracranial_hemorrhage0.56005670
85MP0000778_abnormal_nervous_system0.54493403
86MP0004019_abnormal_vitamin_homeostasis0.53263679
87MP0001243_abnormal_dermal_layer0.53151971
88MP0009703_decreased_birth_body0.51910435
89MP0009697_abnormal_copulation0.51368530
90MP0003119_abnormal_digestive_system0.50244952
91MP0005621_abnormal_cell_physiology0.50179001
92MP0002095_abnormal_skin_pigmentation0.49283373
93MP0002971_abnormal_brown_adipose0.49243627
94MP0005384_cellular_phenotype0.47447216
95MP0001299_abnormal_eye_distance/0.46282844
96MP0004036_abnormal_muscle_relaxation0.45679544
97MP0001986_abnormal_taste_sensitivity0.45366227
98MP0010368_abnormal_lymphatic_system0.44866127
99MP0001293_anophthalmia0.44753728
100MP0006292_abnormal_olfactory_placode0.43515424
101MP0001502_abnormal_circadian_rhythm0.42481068
102MP0002269_muscular_atrophy0.42253624
103MP0008260_abnormal_autophagy0.42014587
104MP0002116_abnormal_craniofacial_bone0.41737533
105MP0002282_abnormal_trachea_morphology0.40347488
106MP0003861_abnormal_nervous_system0.39311763
107MP0009250_abnormal_appendicular_skeleto0.38994037
108MP0003221_abnormal_cardiomyocyte_apopto0.38782448
109MP0000647_abnormal_sebaceous_gland0.35150918
110MP0000631_abnormal_neuroendocrine_gland0.35032430
111MP0002114_abnormal_axial_skeleton0.34900962
112MP0003567_abnormal_fetal_cardiomyocyte0.34622441
113MP0003115_abnormal_respiratory_system0.32939472
114MP0004185_abnormal_adipocyte_glucose0.32210558
115MP0002108_abnormal_muscle_morphology0.31684792
116MP0002396_abnormal_hematopoietic_system0.29142470
117MP0000579_abnormal_nail_morphology0.28392431
118MP0000703_abnormal_thymus_morphology0.28215681
119MP0001919_abnormal_reproductive_system0.28170553
120MP0003632_abnormal_nervous_system0.27884541
121MP0001177_atelectasis0.27855409
122MP0002092_abnormal_eye_morphology0.27139310
123MP0000516_abnormal_urinary_system0.26324816
124MP0005367_renal/urinary_system_phenotyp0.26324816
125MP0000383_abnormal_hair_follicle0.26081921
126MP0003755_abnormal_palate_morphology0.26014755
127MP0000432_abnormal_head_morphology0.25699129
128MP0002233_abnormal_nose_morphology0.25502676
129MP0001849_ear_inflammation0.24328543
130MP0000537_abnormal_urethra_morphology0.24107371
131MP0000613_abnormal_salivary_gland0.24014362
132MP0000569_abnormal_digit_pigmentation0.23656608
133MP0003705_abnormal_hypodermis_morpholog0.22947274
134MP0002139_abnormal_hepatobiliary_system0.22924926
135MP0002075_abnormal_coat/hair_pigmentati0.22879175
136MP0004233_abnormal_muscle_weight0.22357219
137MP0005266_abnormal_metabolism0.21966943
138MP0010678_abnormal_skin_adnexa0.21873102
139MP0001727_abnormal_embryo_implantation0.21599668
140MP0006072_abnormal_retinal_apoptosis0.21335577

Predicted human phenotypes

RankGene SetZ-score
1Abnormal spermatogenesis (HP:0008669)9.49077112
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.54084394
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.54084394
4Abnormality of the lower motor neuron (HP:0002366)5.47981483
5Gonadotropin excess (HP:0000837)5.03812494
6Chromsome breakage (HP:0040012)4.81631694
7Tubulointerstitial nephritis (HP:0001970)4.62149714
8Short nail (HP:0001799)4.20715843
9Abnormality of the corticospinal tract (HP:0002492)4.15295845
10Abnormality of the labia minora (HP:0012880)4.12422311
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10920681
12Facial hemangioma (HP:0000329)4.08628071
13Horizontal nystagmus (HP:0000666)4.06999183
14Broad distal phalanx of finger (HP:0009836)3.88572171
15Papillary thyroid carcinoma (HP:0002895)3.72446189
16Rimmed vacuoles (HP:0003805)3.70957209
17Birth length less than 3rd percentile (HP:0003561)3.65264354
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.61794226
19Breast hypoplasia (HP:0003187)3.54260004
20Spontaneous abortion (HP:0005268)3.51139063
21Male infertility (HP:0003251)3.43048631
22Carpal bone hypoplasia (HP:0001498)3.39734349
23Shoulder girdle muscle weakness (HP:0003547)3.37804093
24Amyotrophic lateral sclerosis (HP:0007354)3.31315767
25Supernumerary spleens (HP:0009799)3.26662471
26Impulsivity (HP:0100710)3.24089786
27Impaired vibration sensation in the lower limbs (HP:0002166)3.18969589
28Abnormality of chromosome stability (HP:0003220)3.16239622
29Upper motor neuron abnormality (HP:0002127)3.15632986
30Capillary hemangiomas (HP:0005306)3.07671637
31Hyperpituitarism (HP:0010514)3.04521170
32Ectopic kidney (HP:0000086)3.00195608
33Large hands (HP:0001176)2.96866298
3411 pairs of ribs (HP:0000878)2.90618946
35Peripheral hypomyelination (HP:0007182)2.89415074
36Type I transferrin isoform profile (HP:0003642)2.88799815
37Ankle contracture (HP:0006466)2.88337464
38Oligodactyly (hands) (HP:0001180)2.84894338
39Abnormal glycosylation (HP:0012345)2.81534553
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.81534553
41Abnormal protein N-linked glycosylation (HP:0012347)2.81534553
42Abnormal protein glycosylation (HP:0012346)2.81534553
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.71030676
44Vertebral arch anomaly (HP:0008438)2.69831685
45Infertility (HP:0000789)2.68976961
46Resting tremor (HP:0002322)2.66981838
47Absent radius (HP:0003974)2.60838146
48Shawl scrotum (HP:0000049)2.60273255
49Absent thumb (HP:0009777)2.60093401
50Patellar aplasia (HP:0006443)2.59725022
51Abnormality of DNA repair (HP:0003254)2.58354673
52Oligodactyly (HP:0012165)2.56803926
53Fibular hypoplasia (HP:0003038)2.55239378
54Selective tooth agenesis (HP:0001592)2.55047014
55Abnormality of the anterior horn cell (HP:0006802)2.52662533
56Degeneration of anterior horn cells (HP:0002398)2.52662533
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.51012412
58Absent/shortened dynein arms (HP:0200106)2.51012412
59Progressive external ophthalmoplegia (HP:0000590)2.50932474
60Absent forearm bone (HP:0003953)2.50868555
61Aplasia involving forearm bones (HP:0009822)2.50868555
62Rhabdomyosarcoma (HP:0002859)2.49677216
63Meckel diverticulum (HP:0002245)2.48032266
64Scotoma (HP:0000575)2.47293757
65Bundle branch block (HP:0011710)2.44922813
66Sandal gap (HP:0001852)2.44798748
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.44253970
68Short tibia (HP:0005736)2.42500372
69Pelvic girdle muscle weakness (HP:0003749)2.36584990
70Menstrual irregularities (HP:0000858)2.35867446
71Premature ovarian failure (HP:0008209)2.35753340
72Facial cleft (HP:0002006)2.35293144
73Aplasia/Hypoplasia of the patella (HP:0006498)2.34005206
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33258186
75Abnormality of alanine metabolism (HP:0010916)2.33258186
76Hyperalaninemia (HP:0003348)2.33258186
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.32431738
78Short thumb (HP:0009778)2.31520214
79Non-midline cleft lip (HP:0100335)2.31100261
80Abnormal lung lobation (HP:0002101)2.31016525
81Duplicated collecting system (HP:0000081)2.27661212
82Thyroid carcinoma (HP:0002890)2.26915457
83Abnormal respiratory motile cilium physiology (HP:0012261)2.25726121
84Abnormality of the ileum (HP:0001549)2.25344837
85Colon cancer (HP:0003003)2.24092633
86Hypoplastic iliac wings (HP:0002866)2.23699777
87Wrist flexion contracture (HP:0001239)2.21355325
88Horseshoe kidney (HP:0000085)2.19799432
89Abnormality of the preputium (HP:0100587)2.19549670
90Small intestinal stenosis (HP:0012848)2.17493846
91Duodenal stenosis (HP:0100867)2.17493846
92Urinary urgency (HP:0000012)2.15290821
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.14914030
94Spastic gait (HP:0002064)2.14559818
95Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10909865
96Lip pit (HP:0100267)2.04949078
97Rhinitis (HP:0012384)2.04624778
98Impaired vibratory sensation (HP:0002495)2.04611431
99Abnormal biliary tract morphology (HP:0012440)2.03384657
100Medulloblastoma (HP:0002885)2.02667833
101Abnormality of chromosome segregation (HP:0002916)2.02030856
102Aplasia/Hypoplasia involving the musculature (HP:0001460)2.01715631
103Chronic bronchitis (HP:0004469)2.00760689
104Nephroblastoma (Wilms tumor) (HP:0002667)2.00414621
105Hand muscle atrophy (HP:0009130)2.00288896
106Limb-girdle muscle weakness (HP:0003325)2.00013678
107Azoospermia (HP:0000027)10.7697854
108Aplasia/Hypoplasia of the fibula (HP:0006492)1.98496054
109Abnormality of the hip-girdle musculature (HP:0001445)1.96485339
110Abnormality of the musculature of the pelvis (HP:0001469)1.96485339
111Decreased subcutaneous fat (HP:0001002)1.95842855
112Abnormality of the renal medulla (HP:0100957)1.94774823
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93764807
114Osteomalacia (HP:0002749)1.93424501
115Breast carcinoma (HP:0003002)1.92567414
116Tubulointerstitial abnormality (HP:0001969)1.90779821
117Abnormality of the dental root (HP:0006486)1.90110587
118Taurodontia (HP:0000679)1.90110587
119Abnormality of permanent molar morphology (HP:0011071)1.90110587
120Metaphyseal cupping (HP:0003021)1.89687255
121Nephronophthisis (HP:0000090)1.89669160
122Abnormality of dentin (HP:0010299)1.86393871
123Neoplasm of striated muscle (HP:0009728)1.84769940
124Ependymoma (HP:0002888)1.84154143
125Abnormality of cochlea (HP:0000375)1.83156150
126Abnormality of the renal collecting system (HP:0004742)1.83085401
127Long foot (HP:0001833)1.82468910
128Abnormality of lateral ventricle (HP:0030047)1.82237785
129Medial flaring of the eyebrow (HP:0010747)1.81769258
130Embryonal renal neoplasm (HP:0011794)1.81692440
131Cafe-au-lait spot (HP:0000957)1.81497664
132Missing ribs (HP:0000921)1.81177291
133Intellectual disability, profound (HP:0002187)1.80189857
134Proximal placement of thumb (HP:0009623)1.79979898
135Anteriorly placed anus (HP:0001545)1.78052679
136External ophthalmoplegia (HP:0000544)1.77415256
137Volvulus (HP:0002580)1.77357859
138Hypergonadotropic hypogonadism (HP:0000815)1.77155128
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.77010486
140Heterotopia (HP:0002282)1.76998337
141Sloping forehead (HP:0000340)1.75350925
142Abnormality of the phalanges of the hallux (HP:0010057)1.75307271
143Increased nuchal translucency (HP:0010880)1.75088140
144Widely spaced teeth (HP:0000687)1.74431213
145Abnormality of molar (HP:0011077)1.72879536
146Abnormality of molar morphology (HP:0011070)1.72879536
147Urinary bladder sphincter dysfunction (HP:0002839)1.72756945
148Abnormality of the aortic arch (HP:0012303)1.72480227
149Multicystic kidney dysplasia (HP:0000003)1.71827424
150Urethral obstruction (HP:0000796)1.71812782
151Loss of speech (HP:0002371)1.70959377
152Enlarged penis (HP:0000040)1.69576330
153Abnormality of the carotid arteries (HP:0005344)1.68977603
154Biliary tract neoplasm (HP:0100574)1.67546253
155Glioma (HP:0009733)1.66127355
156Abnormality of the duodenum (HP:0002246)1.65709186
157Truncal obesity (HP:0001956)1.64634975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.39719945
2CDK197.07804159
3CDC75.95633287
4MET4.98949770
5CDK123.70869772
6MST1R3.20621181
7WEE12.99779436
8OXSR12.79850905
9PDK42.76672601
10PDK32.76672601
11CAMK1G2.76496943
12NEK22.76276300
13TTK2.61198131
14FGR2.34487603
15BRSK22.27159184
16BMX2.23931865
17PLK12.19812796
18PLK42.17894665
19STK38L2.17167129
20NEK11.97314223
21CSF1R1.81447345
22PBK1.81339236
23NEK91.78649939
24STK161.74201165
25PRKD31.69606474
26BUB11.67044049
27ATR1.57094441
28PDK21.55610806
29CHEK11.54462025
30MELK1.50343498
31BRSK11.47778238
32CHEK21.41930241
33MAP3K41.32176569
34PLK31.31441074
35BRD41.31222173
36MAP3K61.30671400
37ATM1.28321172
38IRAK31.26201940
39CDK81.21645984
40STK31.20577785
41TESK11.20074005
42STK241.14554875
43BMPR1B1.14070751
44PDGFRB1.12277308
45EIF2AK11.09925449
46CDK71.09146537
47MKNK21.05889144
48AURKB1.04091964
49DYRK31.03840870
50PTK20.98224771
51TYRO30.96309209
52CCNB10.87476028
53SRPK10.87062072
54PLK20.84666426
55MAP3K100.82359072
56CDK20.80366736
57BMPR20.78856280
58CDK10.77429975
59IRAK10.77372941
60TGFBR10.77230770
61CDC42BPA0.74823490
62CDK40.74752232
63LATS20.74609121
64ZAK0.74380944
65LATS10.73275226
66RPS6KB10.71139941
67KSR10.70752668
68PINK10.69539039
69AURKA0.66487455
70STK40.66064918
71CASK0.65831935
72EGFR0.64156888
73MAP3K50.64073877
74MKNK10.63159976
75MAP3K130.61172589
76STK390.60421897
77PASK0.60370605
78MAP2K20.60053255
79CDK60.59765900
80PDPK10.58894051
81CDK30.58857207
82CDK90.58211573
83MOS0.57026610
84IRAK20.56479305
85MAP3K20.56469492
86KSR20.55060410
87STK110.53692306
88BCR0.52699373
89LIMK10.51702683
90SGK10.50714862
91PDK10.50084775
92CDK11A0.48822297
93MAP3K90.48344915
94NEK60.47366564
95CLK10.45842030
96PRKDC0.44430699
97ICK0.43957427
98EIF2AK30.43398736
99PRKCI0.42971866
100PKN20.42415300
101WNK10.40522156
102PTK2B0.39691137
103MAPK110.39259252
104AKT30.37312151
105ARAF0.37201605
106GSK3B0.36952296
107MAP3K80.36808804
108MTOR0.35956805
109WNK30.35915751
110BRAF0.34948157
111CSNK1D0.34783740
112MAP2K70.34207407
113CSNK2A20.33653519
114MARK30.33536753
115SCYL20.33320459
116IGF1R0.32841466
117DYRK1A0.32626609
118MAPK70.32497013
119CSNK1E0.31724114
120CSNK2A10.30654025
121MAPK80.30443153
122STK100.30204822
123CSNK1G10.29568424
124TSSK60.28178865
125MAP3K120.27402057
126TAOK10.26580325
127TAOK30.26308721
128WNK40.25495069
129VRK10.24747912
130MAP2K40.24152686
131PRKCZ0.23857269
132RET0.22368239
133CAMK10.21926264
134NTRK30.21667991
135RAF10.21663642
136MAPK140.21635971
137PNCK0.21486975
138STK380.21372194
139PAK40.20996814
140MARK10.20141244
141CDK150.17362537
142TAOK20.16999309
143AKT20.16753512
144CDK50.16375561
145TAF10.14979034
146YES10.14607337
147ROCK10.14031246
148CDK180.13399049
149MAPK10.13215417
150MAPK30.11155968

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.38820355
2Basal transcription factors_Homo sapiens_hsa030224.93639179
3Homologous recombination_Homo sapiens_hsa034404.32971099
4DNA replication_Homo sapiens_hsa030304.01373270
5Sulfur relay system_Homo sapiens_hsa041223.78929272
6Mismatch repair_Homo sapiens_hsa034303.65014017
7Cell cycle_Homo sapiens_hsa041103.57611927
8RNA transport_Homo sapiens_hsa030133.43233982
9Fanconi anemia pathway_Homo sapiens_hsa034603.10334447
10mRNA surveillance pathway_Homo sapiens_hsa030152.98655601
11RNA polymerase_Homo sapiens_hsa030202.96511456
12Non-homologous end-joining_Homo sapiens_hsa034502.77517209
13Nucleotide excision repair_Homo sapiens_hsa034202.73853516
14Spliceosome_Homo sapiens_hsa030402.48170845
15Proteasome_Homo sapiens_hsa030502.45386495
16RNA degradation_Homo sapiens_hsa030182.41507988
17Oocyte meiosis_Homo sapiens_hsa041142.30798304
18Base excision repair_Homo sapiens_hsa034102.22736645
19Dorso-ventral axis formation_Homo sapiens_hsa043201.80420982
20Selenocompound metabolism_Homo sapiens_hsa004501.78183014
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74796355
22Pyrimidine metabolism_Homo sapiens_hsa002401.68436143
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66551080
24p53 signaling pathway_Homo sapiens_hsa041151.64214185
25One carbon pool by folate_Homo sapiens_hsa006701.62920236
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44738864
27N-Glycan biosynthesis_Homo sapiens_hsa005101.35037120
28Purine metabolism_Homo sapiens_hsa002301.26310652
29Herpes simplex infection_Homo sapiens_hsa051681.19156611
30Vitamin B6 metabolism_Homo sapiens_hsa007501.12188597
31Epstein-Barr virus infection_Homo sapiens_hsa051691.11754360
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05229813
33SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96622284
34Linoleic acid metabolism_Homo sapiens_hsa005910.95102617
35Protein export_Homo sapiens_hsa030600.90767448
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.90705070
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86129650
38ErbB signaling pathway_Homo sapiens_hsa040120.84116496
39beta-Alanine metabolism_Homo sapiens_hsa004100.83837531
40Thyroid cancer_Homo sapiens_hsa052160.79532253
41TGF-beta signaling pathway_Homo sapiens_hsa043500.77582513
42Lysine degradation_Homo sapiens_hsa003100.73243143
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.71735476
44Retinol metabolism_Homo sapiens_hsa008300.69725343
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67682755
46Pentose phosphate pathway_Homo sapiens_hsa000300.64613900
47Influenza A_Homo sapiens_hsa051640.62587622
48Choline metabolism in cancer_Homo sapiens_hsa052310.62164181
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60882900
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60001430
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58525315
52Viral carcinogenesis_Homo sapiens_hsa052030.58367033
53Legionellosis_Homo sapiens_hsa051340.56885904
54Glycerolipid metabolism_Homo sapiens_hsa005610.55524392
55* HTLV-I infection_Homo sapiens_hsa051660.52256284
56MicroRNAs in cancer_Homo sapiens_hsa052060.52136098
57Fatty acid elongation_Homo sapiens_hsa000620.52090334
58Ether lipid metabolism_Homo sapiens_hsa005650.50682036
59Phenylalanine metabolism_Homo sapiens_hsa003600.48073256
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48046005
61Prion diseases_Homo sapiens_hsa050200.46860882
62Pyruvate metabolism_Homo sapiens_hsa006200.46408817
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46226981
64Hippo signaling pathway_Homo sapiens_hsa043900.45532732
65Peroxisome_Homo sapiens_hsa041460.41496858
66Biosynthesis of amino acids_Homo sapiens_hsa012300.40572236
67Circadian rhythm_Homo sapiens_hsa047100.40458176
68Huntingtons disease_Homo sapiens_hsa050160.40054819
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.39454820
70Pancreatic cancer_Homo sapiens_hsa052120.38140357
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37877662
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37653005
73Adherens junction_Homo sapiens_hsa045200.37345467
74ABC transporters_Homo sapiens_hsa020100.35852678
75FoxO signaling pathway_Homo sapiens_hsa040680.34829782
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34728691
77Endometrial cancer_Homo sapiens_hsa052130.33585838
78Inositol phosphate metabolism_Homo sapiens_hsa005620.32493007
79Ovarian steroidogenesis_Homo sapiens_hsa049130.32343080
80Tight junction_Homo sapiens_hsa045300.31727388
81Small cell lung cancer_Homo sapiens_hsa052220.29776233
82Glutathione metabolism_Homo sapiens_hsa004800.28965360
83Notch signaling pathway_Homo sapiens_hsa043300.27830938
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26846268
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24095221
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22426971
87MAPK signaling pathway_Homo sapiens_hsa040100.20748331
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19867244
89Endocytosis_Homo sapiens_hsa041440.19222550
90Glucagon signaling pathway_Homo sapiens_hsa049220.19104005
91Antigen processing and presentation_Homo sapiens_hsa046120.19046124
92Amoebiasis_Homo sapiens_hsa051460.18841880
93Fatty acid metabolism_Homo sapiens_hsa012120.18023375
94Colorectal cancer_Homo sapiens_hsa052100.17770729
95Shigellosis_Homo sapiens_hsa051310.15149002
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14771534
97Hedgehog signaling pathway_Homo sapiens_hsa043400.13994687
98Type II diabetes mellitus_Homo sapiens_hsa049300.13091711
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12258365
100Regulation of autophagy_Homo sapiens_hsa041400.11949715
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11821777
102Fat digestion and absorption_Homo sapiens_hsa049750.11618391
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10823810
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.09463319
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.09152594
106Pathways in cancer_Homo sapiens_hsa052000.08176967
107Apoptosis_Homo sapiens_hsa042100.07653298
108Wnt signaling pathway_Homo sapiens_hsa043100.06468356
109AMPK signaling pathway_Homo sapiens_hsa041520.06225252
110Olfactory transduction_Homo sapiens_hsa047400.05879558
111Protein digestion and absorption_Homo sapiens_hsa049740.05263698
112Propanoate metabolism_Homo sapiens_hsa006400.04758834
113Fatty acid biosynthesis_Homo sapiens_hsa000610.04634522
114Renal cell carcinoma_Homo sapiens_hsa052110.04405187
115Metabolic pathways_Homo sapiens_hsa011000.04393382
116Carbon metabolism_Homo sapiens_hsa012000.03933530
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.03288928
118Arachidonic acid metabolism_Homo sapiens_hsa005900.02934670
119Prostate cancer_Homo sapiens_hsa052150.02010781
120Systemic lupus erythematosus_Homo sapiens_hsa053220.00843979
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.00527973
122mTOR signaling pathway_Homo sapiens_hsa041500.00101875
123Folate biosynthesis_Homo sapiens_hsa00790-0.0766274
124Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0753099
125Steroid biosynthesis_Homo sapiens_hsa00100-0.0680734
126Long-term potentiation_Homo sapiens_hsa04720-0.0671912
127Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0640071
128VEGF signaling pathway_Homo sapiens_hsa04370-0.0629692
129Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0624992
130Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0436591
131HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0427847
132NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0402550
133Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0341883
134Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0119689
135Basal cell carcinoma_Homo sapiens_hsa05217-0.0109580
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040-0.0036915

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