SLC25A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.07670256
2oxidative phosphorylation (GO:0006119)5.42362429
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.38585623
4NADH metabolic process (GO:0006734)4.86415495
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.78279011
6ATP synthesis coupled proton transport (GO:0015986)4.78279011
7sarcomere organization (GO:0045214)4.50127405
8DNA deamination (GO:0045006)4.30267043
9formation of translation preinitiation complex (GO:0001731)4.12969741
10ribosomal small subunit biogenesis (GO:0042274)4.10241297
11tricarboxylic acid metabolic process (GO:0072350)4.03704862
12establishment of integrated proviral latency (GO:0075713)4.00970164
13ribosomal large subunit biogenesis (GO:0042273)3.93684269
14regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.83445853
15regulation of translational fidelity (GO:0006450)3.82388831
16muscle filament sliding (GO:0030049)3.75868030
17actin-myosin filament sliding (GO:0033275)3.75868030
18IMP biosynthetic process (GO:0006188)3.68851685
19respiratory electron transport chain (GO:0022904)3.64992896
20nucleobase biosynthetic process (GO:0046112)3.63384535
21purine nucleobase biosynthetic process (GO:0009113)3.61965083
22COPI coating of Golgi vesicle (GO:0048205)3.60841517
23Golgi transport vesicle coating (GO:0048200)3.60841517
24regulation of coenzyme metabolic process (GO:0051196)3.57034400
25regulation of cofactor metabolic process (GO:0051193)3.57034400
26electron transport chain (GO:0022900)3.56785814
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55751279
28cardiac muscle contraction (GO:0060048)3.55713770
29oxaloacetate metabolic process (GO:0006107)3.52955152
30mitotic chromosome condensation (GO:0007076)3.50669712
31regulation of mitochondrial translation (GO:0070129)3.50139770
32IMP metabolic process (GO:0046040)3.47781364
33ribosomal small subunit assembly (GO:0000028)3.47180243
34lysine catabolic process (GO:0006554)3.46227988
35lysine metabolic process (GO:0006553)3.46227988
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.46221096
372-oxoglutarate metabolic process (GO:0006103)3.45384328
38cardiac myofibril assembly (GO:0055003)3.44908417
39galactose catabolic process (GO:0019388)3.41849370
40nuclear pore complex assembly (GO:0051292)3.37605648
41regulation of acyl-CoA biosynthetic process (GO:0050812)3.36065107
42proline biosynthetic process (GO:0006561)3.35448775
43establishment of viral latency (GO:0019043)3.34970500
44maturation of SSU-rRNA (GO:0030490)3.29483568
45protein maturation by protein folding (GO:0022417)3.27489663
46translational elongation (GO:0006414)3.27378315
47ribonucleoprotein complex biogenesis (GO:0022613)3.25860583
48regulation of skeletal muscle contraction (GO:0014819)3.23846889
49cardiac muscle cell development (GO:0055013)3.22180577
50viral life cycle (GO:0019058)3.21468375
51cellular protein complex disassembly (GO:0043624)3.20626391
52DNA strand elongation involved in DNA replication (GO:0006271)3.20580432
53viral transcription (GO:0019083)3.20533538
54translational termination (GO:0006415)3.20487350
55folic acid-containing compound biosynthetic process (GO:0009396)3.19958865
56negative regulation of potassium ion transmembrane transport (GO:1901380)3.16730644
57regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.15806811
58ribosome assembly (GO:0042255)3.15719458
59succinate metabolic process (GO:0006105)3.15163209
60nuclear pore organization (GO:0006999)3.14446511
61regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13789686
62purine nucleoside monophosphate biosynthetic process (GO:0009127)3.11897007
63purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.11897007
64peptidyl-arginine omega-N-methylation (GO:0035247)3.08342701
65glycolytic process (GO:0006096)3.06853690
66heart process (GO:0003015)3.06180664
67heart contraction (GO:0060047)3.06180664
68folic acid metabolic process (GO:0046655)3.06096564
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05871118
70regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05560679
71ventricular cardiac muscle cell action potential (GO:0086005)3.04821976
72heterochromatin organization (GO:0070828)3.04620499
73mitotic nuclear envelope reassembly (GO:0007084)3.03776247
74nuclear envelope reassembly (GO:0031468)3.03776247
75translational initiation (GO:0006413)3.02260634
76negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.99898374
77DNA unwinding involved in DNA replication (GO:0006268)2.98953425
78ATP biosynthetic process (GO:0006754)2.96655934
79DNA strand elongation (GO:0022616)2.96573879
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96259785
81protein complex disassembly (GO:0043241)2.95692990
82cardiac cell development (GO:0055006)2.94039600
83actin-mediated cell contraction (GO:0070252)2.93298947
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92769258
85quinone biosynthetic process (GO:1901663)2.92408190
86ubiquinone biosynthetic process (GO:0006744)2.92408190
87regulation of ATP catabolic process (GO:1903289)2.92126221
88regulation of ATPase activity (GO:0043462)2.92126221
89tRNA aminoacylation for protein translation (GO:0006418)2.91700852
90nucleobase-containing small molecule interconversion (GO:0015949)2.91066789
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89253190
92bundle of His cell to Purkinje myocyte communication (GO:0086069)2.88610473
93protein retention in ER lumen (GO:0006621)2.88143502
94purine nucleotide salvage (GO:0032261)2.87888564
95macromolecular complex disassembly (GO:0032984)2.87769454
96valine metabolic process (GO:0006573)2.84878135
97tRNA aminoacylation (GO:0043039)2.83643298
98amino acid activation (GO:0043038)2.83643298
99regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.83213163
100regulation of translational termination (GO:0006449)2.82951937
101ribonucleoside monophosphate biosynthetic process (GO:0009156)2.82834526
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81877031
103plasma membrane repair (GO:0001778)2.81205007
104mitotic sister chromatid segregation (GO:0000070)2.80944157
105maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.80670746
106telomere maintenance via semi-conservative replication (GO:0032201)2.80311570
107L-serine metabolic process (GO:0006563)2.80059357
108gluconeogenesis (GO:0006094)2.78451794
109protein targeting to ER (GO:0045047)2.76920474
110myofibril assembly (GO:0030239)2.76110248
111nucleoside monophosphate biosynthetic process (GO:0009124)2.75422738
112cotranslational protein targeting to membrane (GO:0006613)2.74568646
113cell communication by electrical coupling (GO:0010644)2.74507655
114ventricular cardiac muscle cell development (GO:0055015)2.72022147
115mitotic metaphase plate congression (GO:0007080)2.71708861
116AMP metabolic process (GO:0046033)2.71306940
117ribosome biogenesis (GO:0042254)2.70151117
118DNA replication initiation (GO:0006270)2.69384534
119histone arginine methylation (GO:0034969)2.69361908
120protein complex localization (GO:0031503)2.69331661
121monosaccharide biosynthetic process (GO:0046364)2.69047237
122regulation of sulfur metabolic process (GO:0042762)2.68093920
123translation (GO:0006412)2.66855814
124regulation of relaxation of muscle (GO:1901077)2.66707455
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66568887
126protein targeting to membrane (GO:0006612)2.65541961
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65405532
128hexose biosynthetic process (GO:0019319)2.65038829
129regulation of mitotic spindle organization (GO:0060236)2.62576366
130mitochondrial fusion (GO:0008053)2.62043756
131aerobic respiration (GO:0009060)2.61472765
132protein localization to endoplasmic reticulum (GO:0070972)2.60880137
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60613587
134peptidyl-arginine methylation (GO:0018216)2.59646453
135peptidyl-arginine N-methylation (GO:0035246)2.59646453
136actomyosin structure organization (GO:0031032)2.57579195
137purine-containing compound salvage (GO:0043101)2.57116131
138protein localization to chromosome, centromeric region (GO:0071459)2.57022020
139sister chromatid segregation (GO:0000819)2.56710954
140cellular protein complex localization (GO:0034629)2.56532566
141pore complex assembly (GO:0046931)2.54182000
142paraxial mesoderm development (GO:0048339)2.52858038
143anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43561573
144regulation of cardioblast differentiation (GO:0051890)2.42895231
145cellular component biogenesis (GO:0044085)2.41561512
146regulation of translational elongation (GO:0006448)2.40005641
147mitotic nuclear envelope disassembly (GO:0007077)2.39248295
148nuclear-transcribed mRNA catabolic process (GO:0000956)2.38048595
149pyruvate metabolic process (GO:0006090)2.36729775
150regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.34872657
151negative regulation of ligase activity (GO:0051352)2.34395096
152negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.34395096
153proteasome assembly (GO:0043248)2.30130402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.65755185
2E2F7_22180533_ChIP-Seq_HELA_Human4.33879906
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.03717822
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.27031048
5* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72424807
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64449544
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.64105011
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59900882
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47002620
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.45224199
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41519840
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39863080
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31111117
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.21542043
15XRN2_22483619_ChIP-Seq_HELA_Human2.19581815
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16094705
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13264582
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12647680
19* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10139861
20* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.09129994
21* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95116000
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.85949673
23DCP1A_22483619_ChIP-Seq_HELA_Human1.84984039
24ZNF263_19887448_ChIP-Seq_K562_Human1.83504480
25MYC_22102868_ChIP-Seq_BL_Human1.81976112
26GABP_19822575_ChIP-Seq_HepG2_Human1.81625750
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79674677
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77824306
29CIITA_25753668_ChIP-Seq_RAJI_Human1.72505632
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72406696
31* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71732083
32* VDR_23849224_ChIP-Seq_CD4+_Human1.69801375
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69539017
34* AR_21909140_ChIP-Seq_LNCAP_Human1.66225704
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63488942
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61525562
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.59128141
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56350468
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56140635
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53997599
41TTF2_22483619_ChIP-Seq_HELA_Human1.53363388
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51643186
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50316405
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.49941633
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49281858
46CLOCK_20551151_ChIP-Seq_293T_Human1.47941203
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47304936
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.47098086
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44896065
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43317491
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42568535
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42367127
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42244784
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.42115150
55* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40178725
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39604681
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38486088
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34617558
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33878566
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33580683
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31840317
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31153257
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30909214
64* ATF3_27146783_Chip-Seq_COLON_Human1.30511906
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29727310
66TFEB_21752829_ChIP-Seq_HELA_Human1.28923823
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28311628
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28149930
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.27315873
70* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26610424
71VDR_21846776_ChIP-Seq_THP-1_Human1.26442962
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25665695
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24510925
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23110471
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21140093
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18918701
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.18831706
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18516363
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18453300
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18412656
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18358316
82* SOX17_20123909_ChIP-Seq_XEN_Mouse1.17306946
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15279306
84ELK1_19687146_ChIP-ChIP_HELA_Human1.13743575
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12878234
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11682489
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10227571
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10162942
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10078554
90KDM5A_27292631_Chip-Seq_BREAST_Human1.10007323
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09825407
92GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09357146
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09347957
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.08168432
95TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07704585
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07562926
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05818552
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.05612192
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05594454
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05271118
101* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04432513
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04412849
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03038259
104CHD1_26751641_Chip-Seq_LNCaP_Human1.02852428
105TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02797545
106* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02414783
107* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02061490
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02044256
109TP63_17297297_ChIP-ChIP_HaCaT_Human1.00904044
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00576389
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00454424
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00110339
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99872869
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98828273
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96864629
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95625735
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95531523
118GATA1_22025678_ChIP-Seq_K562_Human0.94014352
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93961055
120YY1_22570637_ChIP-Seq_MALME-3M_Human0.92823434
121* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91772366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.53107289
2MP0004215_abnormal_myocardial_fiber3.54908131
3MP0002837_dystrophic_cardiac_calcinosis3.44529289
4MP0000751_myopathy3.41584655
5MP0003646_muscle_fatigue3.39708917
6MP0005330_cardiomyopathy3.00138417
7MP0004036_abnormal_muscle_relaxation2.94358253
8MP0000749_muscle_degeneration2.91574634
9MP0003693_abnormal_embryo_hatching2.77501902
10MP0000750_abnormal_muscle_regeneration2.69918602
11MP0006036_abnormal_mitochondrial_physio2.59204580
12MP0005451_abnormal_body_composition2.52698850
13MP0004087_abnormal_muscle_fiber2.27890363
14MP0002269_muscular_atrophy2.25271567
15MP0004957_abnormal_blastocyst_morpholog2.22233383
16MP0003221_abnormal_cardiomyocyte_apopto2.19694258
17MP0002972_abnormal_cardiac_muscle2.12764347
18MP0009379_abnormal_foot_pigmentation2.11833613
19MP0004233_abnormal_muscle_weight2.05891360
20MP0000537_abnormal_urethra_morphology2.05804815
21MP0003941_abnormal_skin_development2.02181625
22MP0000747_muscle_weakness2.01740827
23MP0003806_abnormal_nucleotide_metabolis1.99585578
24MP0004043_abnormal_pH_regulation1.98088724
25MP0008775_abnormal_heart_ventricle1.96790980
26MP0010630_abnormal_cardiac_muscle1.96129663
27MP0001544_abnormal_cardiovascular_syste1.94589092
28MP0005385_cardiovascular_system_phenoty1.94589092
29MP0002106_abnormal_muscle_physiology1.88675215
30MP0010352_gastrointestinal_tract_polyps1.81160605
31MP0003567_abnormal_fetal_cardiomyocyte1.78491027
32MP0005620_abnormal_muscle_contractility1.77884071
33MP0006035_abnormal_mitochondrial_morpho1.76480544
34MP0010234_abnormal_vibrissa_follicle1.75998700
35MP0004272_abnormal_basement_membrane1.71110583
36MP0003137_abnormal_impulse_conducting1.59903467
37MP0004484_altered_response_of1.55299242
38MP0003315_abnormal_perineum_morphology1.53373948
39MP0003077_abnormal_cell_cycle1.49693503
40MP0003111_abnormal_nucleus_morphology1.48873584
41MP0000759_abnormal_skeletal_muscle1.43631101
42MP0001730_embryonic_growth_arrest1.42922028
43MP0006138_congestive_heart_failure1.42709627
44MP0003828_pulmonary_edema1.42071359
45MP0003123_paternal_imprinting1.40996562
46MP0006054_spinal_hemorrhage1.39800764
47MP0004130_abnormal_muscle_cell1.39358237
48MP0003705_abnormal_hypodermis_morpholog1.38661848
49MP0005369_muscle_phenotype1.37132242
50MP0008260_abnormal_autophagy1.33875570
51MP0004185_abnormal_adipocyte_glucose1.33086823
52MP0009643_abnormal_urine_homeostasis1.31442404
53MP0000013_abnormal_adipose_tissue1.31149731
54MP0009697_abnormal_copulation1.30498087
55MP0003186_abnormal_redox_activity1.30232254
56MP0009840_abnormal_foam_cell1.29596139
57MP0000358_abnormal_cell_content/1.29084121
58MP0004145_abnormal_muscle_electrophysio1.26934341
59MP0010094_abnormal_chromosome_stability1.23151711
60MP0005332_abnormal_amino_acid1.22374822
61MP0002396_abnormal_hematopoietic_system1.22018159
62MP0005257_abnormal_intraocular_pressure1.21742538
63MP0008058_abnormal_DNA_repair1.21046877
64MP0008007_abnormal_cellular_replicative1.20800505
65MP0002127_abnormal_cardiovascular_syste1.19785457
66MP0001756_abnormal_urination1.19620163
67MP0003566_abnormal_cell_adhesion1.17654544
68MP0001661_extended_life_span1.17246771
69MP0002234_abnormal_pharynx_morphology1.15623604
70MP0002085_abnormal_embryonic_tissue1.15619594
71MP0000762_abnormal_tongue_morphology1.14392919
72MP0002697_abnormal_eye_size1.13081338
73MP0002877_abnormal_melanocyte_morpholog1.11898919
74MP0003984_embryonic_growth_retardation1.11549993
75MP0002909_abnormal_adrenal_gland1.10107319
76MP0005266_abnormal_metabolism1.09638342
77MP0001853_heart_inflammation1.09458323
78MP0002084_abnormal_developmental_patter1.09274887
79MP0003878_abnormal_ear_physiology1.08996888
80MP0005377_hearing/vestibular/ear_phenot1.08996888
81MP0005501_abnormal_skin_physiology1.08598747
82MP0001293_anophthalmia1.08275532
83MP0002088_abnormal_embryonic_growth/wei1.07707807
84MP0000566_synostosis1.05612251
85MP0001727_abnormal_embryo_implantation1.04056713
86MP0008438_abnormal_cutaneous_collagen1.02913860
87MP0000733_abnormal_muscle_development1.02589694
88MP0002080_prenatal_lethality1.02475412
89MP0003385_abnormal_body_wall1.02214532
90MP0000266_abnormal_heart_morphology1.01024222
91MP0001299_abnormal_eye_distance/1.01005539
92MP0001697_abnormal_embryo_size1.00342155
93MP0000343_altered_response_to1.00332854
94MP0001849_ear_inflammation1.00288772
95MP0005319_abnormal_enzyme/_coenzyme0.99679056
96MP0003283_abnormal_digestive_organ0.99259437
97MP0000490_abnormal_crypts_of0.97311467
98MP0005165_increased_susceptibility_to0.97209453
99MP0005670_abnormal_white_adipose0.97208308
100MP0004197_abnormal_fetal_growth/weight/0.97036419
101MP0003279_aneurysm0.96491034
102MP0004858_abnormal_nervous_system0.95575528
103MP0004147_increased_porphyrin_level0.95427531
104MP0004085_abnormal_heartbeat0.95347953
105MP0001346_abnormal_lacrimal_gland0.93706878
106MP0005380_embryogenesis_phenotype0.93336356
107MP0001672_abnormal_embryogenesis/_devel0.93336356
108MP0009053_abnormal_anal_canal0.91537139
109MP0008789_abnormal_olfactory_epithelium0.91278016
110MP0005666_abnormal_adipose_tissue0.89760972
111MP0000350_abnormal_cell_proliferation0.89443783
112MP0002092_abnormal_eye_morphology0.88919513
113MP0005636_abnormal_mineral_homeostasis0.88672704
114MP0001765_abnormal_ion_homeostasis0.84148364
115MP0005623_abnormal_meninges_morphology0.82338005
116MP0008961_abnormal_basal_metabolism0.81820068
117MP0008932_abnormal_embryonic_tissue0.81336289
118MP0004808_abnormal_hematopoietic_stem0.81073074
119MP0003937_abnormal_limbs/digits/tail_de0.80097664
120MP0003786_premature_aging0.79852823
121MP0002796_impaired_skin_barrier0.78643410
122MP0002332_abnormal_exercise_endurance0.78638984
123MP0010030_abnormal_orbit_morphology0.78356940
124MP0005499_abnormal_olfactory_system0.77587808
125MP0005394_taste/olfaction_phenotype0.77587808
126MP0001529_abnormal_vocalization0.76842974
127MP0000003_abnormal_adipose_tissue0.76649025
128MP0002089_abnormal_postnatal_growth/wei0.76398335
129MP0003300_gastrointestinal_ulcer0.75969224
130MP0000313_abnormal_cell_death0.75480481
131MP0005375_adipose_tissue_phenotype0.72214957
132MP0002086_abnormal_extraembryonic_tissu0.72088652
133MP0005360_urolithiasis0.68280889
134MP0000230_abnormal_systemic_arterial0.66940777
135MP0004510_myositis0.65600269
136MP0002136_abnormal_kidney_physiology0.65122507
137MP0009672_abnormal_birth_weight0.64562229
138MP0005584_abnormal_enzyme/coenzyme_acti0.63820826
139MP0010368_abnormal_lymphatic_system0.63594094

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)4.58665013
2Sudden death (HP:0001699)4.20593036
3Exercise-induced muscle cramps (HP:0003710)4.12866341
4Rhabdomyolysis (HP:0003201)4.01142203
5Ventricular tachycardia (HP:0004756)3.90985137
6Palpitations (HP:0001962)3.87737802
7Hepatic necrosis (HP:0002605)3.81425626
8Nemaline bodies (HP:0003798)3.43845314
9Exercise-induced myalgia (HP:0003738)3.39941088
10Hypoglycemic coma (HP:0001325)3.38014459
11Abnormality of alanine metabolism (HP:0010916)3.32963898
12Hyperalaninemia (HP:0003348)3.32963898
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.32963898
14Abnormal mitochondria in muscle tissue (HP:0008316)3.29931337
15Hepatocellular necrosis (HP:0001404)3.29135232
16Ventricular fibrillation (HP:0001663)3.16581797
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11639919
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11639919
19Right ventricular cardiomyopathy (HP:0011663)3.10468542
20Lipoatrophy (HP:0100578)3.09107116
21Ketoacidosis (HP:0001993)3.06089445
22Multiple enchondromatosis (HP:0005701)3.05749077
23Generalized aminoaciduria (HP:0002909)3.03467336
24Ragged-red muscle fibers (HP:0003200)3.03461522
25Muscle fiber splitting (HP:0003555)3.02263444
26Dicarboxylic aciduria (HP:0003215)3.01038121
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.01038121
28Acute necrotizing encephalopathy (HP:0006965)2.99509512
29Calf muscle hypertrophy (HP:0008981)2.99034204
30Increased muscle lipid content (HP:0009058)2.98820645
31Increased CSF lactate (HP:0002490)2.95777479
32Atrial fibrillation (HP:0005110)2.95076847
33Reticulocytopenia (HP:0001896)2.88817750
34Supraventricular tachycardia (HP:0004755)2.88241762
35Dilated cardiomyopathy (HP:0001644)2.85417073
36Progressive muscle weakness (HP:0003323)2.83433624
37Supraventricular arrhythmia (HP:0005115)2.83067783
38Ventricular arrhythmia (HP:0004308)2.82019424
39Mitochondrial inheritance (HP:0001427)2.81995433
40Abnormality of fatty-acid metabolism (HP:0004359)2.79317677
41Acute encephalopathy (HP:0006846)2.78569263
42Primary atrial arrhythmia (HP:0001692)2.78190027
43Syncope (HP:0001279)2.75290562
44Increased intramyocellular lipid droplets (HP:0012240)2.75013433
45Bundle branch block (HP:0011710)2.74977702
46Subaortic stenosis (HP:0001682)2.73824575
47Abnormality of the left ventricular outflow tract (HP:0011103)2.73824575
48* Lactic acidosis (HP:0003128)2.71811023
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.70136045
50Limb-girdle muscle atrophy (HP:0003797)2.69518752
51Asymmetric septal hypertrophy (HP:0001670)2.69229871
52Gout (HP:0001997)2.68658322
53Microvesicular hepatic steatosis (HP:0001414)2.65467777
54Difficulty climbing stairs (HP:0003551)2.65162453
55Increased serum lactate (HP:0002151)2.62832444
56Abnormality of the calf musculature (HP:0001430)2.61542488
57Muscle hypertrophy of the lower extremities (HP:0008968)2.58781192
58Exercise intolerance (HP:0003546)2.55539924
59Hyperglycinuria (HP:0003108)2.54387219
60Shoulder girdle muscle weakness (HP:0003547)2.53380312
61Neoplasm of the adrenal gland (HP:0100631)2.52138134
62Distal lower limb amyotrophy (HP:0008944)2.49585407
63Increased connective tissue (HP:0009025)2.46648331
64Rimmed vacuoles (HP:0003805)2.45280736
65Proximal tubulopathy (HP:0000114)2.36406491
66Nausea (HP:0002018)2.35925473
67Prolonged QT interval (HP:0001657)2.33077260
68Hyperammonemia (HP:0001987)2.31415756
69Atrioventricular block (HP:0001678)2.31223020
70Microglossia (HP:0000171)2.28953529
71Lipid accumulation in hepatocytes (HP:0006561)2.28794978
72Cerebral edema (HP:0002181)2.28190370
73Respiratory failure (HP:0002878)2.26918297
74Late onset (HP:0003584)2.25859281
75EMG: myopathic abnormalities (HP:0003458)2.23837745
76Calcaneovalgus deformity (HP:0001848)2.23213065
77Conjunctival hamartoma (HP:0100780)2.22405975
78Progressive macrocephaly (HP:0004481)2.21702718
79Heart block (HP:0012722)2.20386313
80Ketosis (HP:0001946)2.17894829
81Neck muscle weakness (HP:0000467)2.15135524
82Angiofibromas (HP:0010615)2.15005387
83Adenoma sebaceum (HP:0009720)2.15005387
84Cholecystitis (HP:0001082)2.13448519
85Abnormal gallbladder physiology (HP:0012438)2.13448519
86Abnormal atrioventricular conduction (HP:0005150)2.12352739
87Achilles tendon contracture (HP:0001771)2.12263487
88Cortical dysplasia (HP:0002539)2.09676100
89Muscle stiffness (HP:0003552)2.09578074
90CNS demyelination (HP:0007305)2.08696275
91Abnormal number of erythroid precursors (HP:0012131)2.08633774
92Abnormality of the calcaneus (HP:0008364)2.08367500
93Macrocytic anemia (HP:0001972)2.08282210
94Emotional lability (HP:0000712)2.07758287
95Myotonia (HP:0002486)2.06242769
96Deformed tarsal bones (HP:0008119)2.06193053
97Abnormality of glycolysis (HP:0004366)2.05955628
98Increased serum pyruvate (HP:0003542)2.05955628
99Muscle fiber inclusion bodies (HP:0100299)2.05606463
100Pelvic girdle muscle weakness (HP:0003749)2.05494153
101Trismus (HP:0000211)2.05396873
102Mildly elevated creatine phosphokinase (HP:0008180)2.02587132
103Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02053796
104Insomnia (HP:0100785)2.01254365
105Abnormality of cells of the erythroid lineage (HP:0012130)2.00372971
106Premature rupture of membranes (HP:0001788)2.00346251
107Progressive external ophthalmoplegia (HP:0000590)1.99876193
108Abnormality of glycine metabolism (HP:0010895)1.98088994
109Abnormality of serine family amino acid metabolism (HP:0010894)1.98088994
110Areflexia of lower limbs (HP:0002522)1.97481086
111Distal lower limb muscle weakness (HP:0009053)1.97027538
112Lethargy (HP:0001254)1.94567645
113Hyperacusis (HP:0010780)1.94317702
114Hyperuricemia (HP:0002149)1.94033533
115Increased purine levels (HP:0004368)1.94033533
116Increased hepatocellular lipid droplets (HP:0006565)1.91130417
117Type 1 muscle fiber predominance (HP:0003803)1.89319895
118Abnormality of urine glucose concentration (HP:0011016)1.88948098
119Glycosuria (HP:0003076)1.88948098
120Abnormal EKG (HP:0003115)1.88823527
121Myopathic facies (HP:0002058)1.88726076
122Abnormality of reticulocytes (HP:0004312)1.86698896
123Microretrognathia (HP:0000308)1.86663204
124Hyporeflexia of lower limbs (HP:0002600)1.85974702
125Abnormality of the hip-girdle musculature (HP:0001445)1.83583846
126Abnormality of the musculature of the pelvis (HP:0001469)1.83583846
127Spinal rigidity (HP:0003306)1.83185845
128Abnormality of skeletal muscle fiber size (HP:0012084)1.80426383
129Neuroendocrine neoplasm (HP:0100634)1.80130850
130Proximal placement of thumb (HP:0009623)1.79595320
131High anterior hairline (HP:0009890)1.79152477
132Lower limb amyotrophy (HP:0007210)1.78389462
133Abnormality of the Achilles tendon (HP:0005109)1.77643663
134Abnormality of the anterior horn cell (HP:0006802)1.77409709
135Degeneration of anterior horn cells (HP:0002398)1.77409709
136Scapular winging (HP:0003691)1.77036763
137Vertebral compression fractures (HP:0002953)1.76922914
138Deviation of the thumb (HP:0009603)1.73286504
139Breech presentation (HP:0001623)1.69883168
140Hypokinesia (HP:0002375)1.68820463
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66053920
142Abnormality of the umbilical cord (HP:0010881)1.65869538
143Overriding aorta (HP:0002623)1.65505022
144Protrusio acetabuli (HP:0003179)1.62569477
145Abnormality of the tricuspid valve (HP:0001702)1.59994342
146Increased variability in muscle fiber diameter (HP:0003557)1.59071536
147Back pain (HP:0003418)1.58193754
148Spastic diplegia (HP:0001264)1.58057168
149Generalized amyotrophy (HP:0003700)1.57856082
150Abnormality of the foot musculature (HP:0001436)1.53755609
151Testicular atrophy (HP:0000029)1.53240849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.15185469
2PKN23.38805001
3BCKDK3.26435831
4LMTK23.07512451
5TTN3.06304596
6TRIB33.05791639
7NME22.95686806
8WEE12.67571127
9PBK2.42407371
10SRPK12.40530370
11PDK42.36626401
12PDK32.36626401
13BUB12.24769377
14OBSCN2.24333924
15FLT32.11411978
16SCYL22.03138778
17ARAF2.01163562
18EIF2AK11.96493323
19CDK191.95647941
20MAPKAPK31.93948005
21MAP3K111.82426850
22SMG11.78649767
23MAP2K31.76873023
24VRK21.74245383
25RPS6KA41.70170793
26MYLK1.57989185
27PHKG21.56075682
28PHKG11.56075682
29LATS21.55189137
30ERN11.54177380
31KDR1.48716591
32ICK1.46577535
33NME11.40945024
34LRRK21.34276290
35ACVR1B1.32434805
36BRSK21.23972985
37TGFBR11.22902161
38RPS6KB21.21074213
39PDK21.20661980
40BRAF1.20312178
41MST1R1.19938794
42MAP3K31.18573457
43TESK11.17606957
44PASK1.14473438
45STK161.13137470
46STK241.12532632
47TSSK61.12423921
48NEK21.12411925
49WNK31.09748556
50WNK41.08616632
51CDC71.08369914
52EPHB21.08097580
53PAK41.07524080
54TAOK21.05066413
55EIF2AK31.03557315
56ILK1.01841449
57EPHA21.00899123
58EEF2K1.00857689
59PRPF4B0.98646122
60MOS0.98089089
61PIM20.97638108
62TESK20.94966039
63MAP3K80.93449167
64MET0.91170929
65ERBB40.90773126
66STK38L0.90170902
67CDK40.88509685
68PTK20.86404359
69DYRK30.86350758
70AURKB0.86050265
71MAP3K100.85600132
72MAP3K50.85007036
73PLK40.84078576
74NEK90.83569492
75KSR20.82666221
76CHEK20.81615205
77MAP3K90.81551100
78TAF10.81357882
79CDK80.81180460
80TAOK10.79120236
81PINK10.75929237
82MKNK10.75827493
83PRKG20.74800404
84PDGFRA0.74410238
85CDK11A0.73109229
86TTK0.70693949
87ZAK0.69980252
88RIPK10.69201595
89PLK10.66985791
90CDK140.66408818
91BRSK10.64213696
92CDK180.64191637
93CDK150.64172741
94CHEK10.62471603
95PTK60.62148759
96LIMK10.61206067
97TIE10.60589881
98ERBB30.59221911
99PIK3CG0.58162062
100IRAK30.57486710
101ABL20.55415901
102DMPK0.55239399
103PLK30.53702345
104ZAP700.53579505
105MAP2K60.53020187
106CDK70.52591716
107CSNK1G30.52523822
108AKT20.52506543
109MAP3K120.51924505
110TBK10.49653219
111AURKA0.49438142
112KSR10.49412901
113NTRK10.49332211
114BCR0.48981543
115CSNK1A1L0.48974695
116DAPK10.48973141
117SIK10.47138460
118MAP4K10.46656762
119PAK30.46337055
120TRIM280.45877289
121MTOR0.45702329
122STK40.44856254
123STK100.41910500
124MAP3K70.39723426
125MAP2K20.37530153
126PRKCI0.36160981
127ATR0.35865184
128DAPK30.33906275
129STK380.31972765
130VRK10.31824971
131MAPK110.31350093
132MAP3K10.30739257
133PAK20.29081959
134CAMKK20.28533320
135CDK60.27309217
136MAP2K10.27159631
137ALK0.27013753
138PAK10.26937121
139PIK3CA0.25671906
140RAF10.25068887
141JAK30.24938178
142CSNK2A10.23383976

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.85027338
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.30625945
3DNA replication_Homo sapiens_hsa030302.91792751
4Carbon metabolism_Homo sapiens_hsa012002.78056309
5Proteasome_Homo sapiens_hsa030502.70995249
6Parkinsons disease_Homo sapiens_hsa050122.68720530
7Ribosome_Homo sapiens_hsa030102.58721365
8Oxidative phosphorylation_Homo sapiens_hsa001902.39865034
9Cardiac muscle contraction_Homo sapiens_hsa042602.31284164
10Fatty acid degradation_Homo sapiens_hsa000712.09518583
11Biosynthesis of amino acids_Homo sapiens_hsa012302.09006383
12Mismatch repair_Homo sapiens_hsa034302.07070211
13Propanoate metabolism_Homo sapiens_hsa006402.05668016
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.97014817
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94902226
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85872076
17Huntingtons disease_Homo sapiens_hsa050161.70503546
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69436977
19Pyruvate metabolism_Homo sapiens_hsa006201.65788733
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65749106
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64217224
22Galactose metabolism_Homo sapiens_hsa000521.62599661
23Fatty acid elongation_Homo sapiens_hsa000621.59961812
24RNA transport_Homo sapiens_hsa030131.57197885
25Alzheimers disease_Homo sapiens_hsa050101.53892318
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51677648
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51458002
28Base excision repair_Homo sapiens_hsa034101.49553930
29Pyrimidine metabolism_Homo sapiens_hsa002401.47629457
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.46712754
31Folate biosynthesis_Homo sapiens_hsa007901.46176113
32Spliceosome_Homo sapiens_hsa030401.44967138
33Fructose and mannose metabolism_Homo sapiens_hsa000511.41825709
34Pentose phosphate pathway_Homo sapiens_hsa000301.37324200
35RNA polymerase_Homo sapiens_hsa030201.34568257
36Arginine biosynthesis_Homo sapiens_hsa002201.31748595
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28983621
38Sulfur relay system_Homo sapiens_hsa041221.24939851
39One carbon pool by folate_Homo sapiens_hsa006701.22768984
40Dilated cardiomyopathy_Homo sapiens_hsa054141.17897848
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13167012
42Nucleotide excision repair_Homo sapiens_hsa034201.11342221
43Non-homologous end-joining_Homo sapiens_hsa034501.09139596
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07032516
45Fatty acid metabolism_Homo sapiens_hsa012121.04973116
46Steroid biosynthesis_Homo sapiens_hsa001000.99252893
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.98366563
48Vitamin B6 metabolism_Homo sapiens_hsa007500.96128574
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93534376
50Cell cycle_Homo sapiens_hsa041100.88655983
51Selenocompound metabolism_Homo sapiens_hsa004500.86330309
52Starch and sucrose metabolism_Homo sapiens_hsa005000.84646309
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81048871
54Glutathione metabolism_Homo sapiens_hsa004800.80836362
55Homologous recombination_Homo sapiens_hsa034400.79662604
56Purine metabolism_Homo sapiens_hsa002300.79217578
57p53 signaling pathway_Homo sapiens_hsa041150.78012908
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77579928
59Adherens junction_Homo sapiens_hsa045200.74532867
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71627943
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71033427
62RNA degradation_Homo sapiens_hsa030180.70869194
63Thyroid cancer_Homo sapiens_hsa052160.68616277
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.67832546
65Legionellosis_Homo sapiens_hsa051340.65024520
66Arginine and proline metabolism_Homo sapiens_hsa003300.63490049
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62120145
68Butanoate metabolism_Homo sapiens_hsa006500.60327045
69HIF-1 signaling pathway_Homo sapiens_hsa040660.59453924
70Protein export_Homo sapiens_hsa030600.59236345
71Fanconi anemia pathway_Homo sapiens_hsa034600.58098694
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57999959
73Viral myocarditis_Homo sapiens_hsa054160.57153898
74Glucagon signaling pathway_Homo sapiens_hsa049220.56928921
75Hippo signaling pathway_Homo sapiens_hsa043900.56841283
76Tight junction_Homo sapiens_hsa045300.52914581
77Metabolic pathways_Homo sapiens_hsa011000.52165232
78Vibrio cholerae infection_Homo sapiens_hsa051100.50326678
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.49165472
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47821651
81beta-Alanine metabolism_Homo sapiens_hsa004100.46936025
82Fat digestion and absorption_Homo sapiens_hsa049750.46111805
83N-Glycan biosynthesis_Homo sapiens_hsa005100.43701256
84Epstein-Barr virus infection_Homo sapiens_hsa051690.42214119
85Insulin resistance_Homo sapiens_hsa049310.41731511
86Renin-angiotensin system_Homo sapiens_hsa046140.41481499
87Sulfur metabolism_Homo sapiens_hsa009200.39725216
88Basal cell carcinoma_Homo sapiens_hsa052170.39674736
89Lysine degradation_Homo sapiens_hsa003100.39033780
90Insulin signaling pathway_Homo sapiens_hsa049100.38811362
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.38801371
92Chronic myeloid leukemia_Homo sapiens_hsa052200.38426024
93Alcoholism_Homo sapiens_hsa050340.37713220
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37331166
95Antigen processing and presentation_Homo sapiens_hsa046120.36521291
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36300264
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35130313
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34947985
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34758891
100Tyrosine metabolism_Homo sapiens_hsa003500.34205470
101Bladder cancer_Homo sapiens_hsa052190.33968439
102Focal adhesion_Homo sapiens_hsa045100.32148239
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.31879262
104Tryptophan metabolism_Homo sapiens_hsa003800.31784874
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30506571
106Peroxisome_Homo sapiens_hsa041460.29756001
107Basal transcription factors_Homo sapiens_hsa030220.29437106
108Colorectal cancer_Homo sapiens_hsa052100.29422643
109Viral carcinogenesis_Homo sapiens_hsa052030.28613128
110AMPK signaling pathway_Homo sapiens_hsa041520.25797609
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25396676
112Phenylalanine metabolism_Homo sapiens_hsa003600.24693071
113Circadian rhythm_Homo sapiens_hsa047100.24042350
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23813115
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23339067
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21692098
117Oocyte meiosis_Homo sapiens_hsa041140.20565608
118Mineral absorption_Homo sapiens_hsa049780.19467868
119Small cell lung cancer_Homo sapiens_hsa052220.18776226
120Regulation of autophagy_Homo sapiens_hsa041400.18074476
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17947034
122Protein digestion and absorption_Homo sapiens_hsa049740.17521711
123HTLV-I infection_Homo sapiens_hsa051660.17378154
124mRNA surveillance pathway_Homo sapiens_hsa030150.16852392
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16019033
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15852625

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