SLC25A29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.50265831
2daunorubicin metabolic process (GO:0044597)7.50265831
3polyketide metabolic process (GO:0030638)7.50265831
4axonemal dynein complex assembly (GO:0070286)6.51887734
5cilium or flagellum-dependent cell motility (GO:0001539)6.12227419
6motile cilium assembly (GO:0044458)5.34311403
7cilium movement (GO:0003341)5.00324532
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.97014924
9response to dietary excess (GO:0002021)4.83294209
10semaphorin-plexin signaling pathway (GO:0071526)4.81314726
11aminoglycoside antibiotic metabolic process (GO:0030647)4.77444943
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.59666730
13maintenance of protein location in nucleus (GO:0051457)4.55063820
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.54791615
15establishment of apical/basal cell polarity (GO:0035089)4.21461464
16coenzyme catabolic process (GO:0009109)4.20304802
17cell migration in hindbrain (GO:0021535)4.14617970
18lung epithelium development (GO:0060428)4.11378665
19somite rostral/caudal axis specification (GO:0032525)4.04793051
20cytidine deamination (GO:0009972)3.98692375
21cytidine metabolic process (GO:0046087)3.98692375
22cytidine catabolic process (GO:0006216)3.98692375
23cellular modified amino acid catabolic process (GO:0042219)3.91335530
24synaptic vesicle maturation (GO:0016188)3.89895760
25regulation of response to osmotic stress (GO:0047484)3.87210639
26muscle organ morphogenesis (GO:0048644)3.85097201
27maintenance of protein localization in organelle (GO:0072595)3.79630030
28proline transport (GO:0015824)3.78750593
29hormone catabolic process (GO:0042447)3.77774454
30pyrimidine ribonucleoside catabolic process (GO:0046133)3.77055790
31establishment or maintenance of monopolar cell polarity (GO:0061339)3.65563366
32establishment of monopolar cell polarity (GO:0061162)3.65563366
33regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.64027030
34epithelial cilium movement (GO:0003351)3.62790120
35detection of temperature stimulus (GO:0016048)3.62769523
36negative regulation of cell size (GO:0045792)3.61899519
37protein targeting to Golgi (GO:0000042)3.60598614
38regulation of glucose import in response to insulin stimulus (GO:2001273)3.60434020
39left/right pattern formation (GO:0060972)3.60130043
40cell-cell junction maintenance (GO:0045217)3.55559362
41thyroid hormone generation (GO:0006590)3.55426901
42calcium-mediated signaling using intracellular calcium source (GO:0035584)3.50438867
43ear development (GO:0043583)3.49799005
44axoneme assembly (GO:0035082)3.47847903
45apical protein localization (GO:0045176)3.42092942
46phenol-containing compound catabolic process (GO:0019336)3.41650848
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.37310460
48mannose metabolic process (GO:0006013)3.37193658
49negative regulation of potassium ion transmembrane transport (GO:1901380)3.34007456
50GDP-mannose metabolic process (GO:0019673)3.32766001
51Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.32422190
52protein palmitoylation (GO:0018345)3.30915655
53regulation of MHC class I biosynthetic process (GO:0045343)3.29733872
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.28371998
55creatine metabolic process (GO:0006600)3.26088585
56icosanoid secretion (GO:0032309)3.25241190
57arachidonic acid secretion (GO:0050482)3.25241190
58endothelial cell chemotaxis (GO:0035767)3.24793624
59convergent extension (GO:0060026)3.24631881
60peptidyl-tyrosine autophosphorylation (GO:0038083)3.24174290
61intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.21531326
62negative regulation of erythrocyte differentiation (GO:0045647)3.15054809
63regulation of establishment of planar polarity (GO:0090175)3.13877251
64regulation of ARF GTPase activity (GO:0032312)3.10941526
65negative regulation of complement activation (GO:0045916)3.10639551
66ventricular system development (GO:0021591)3.09483884
67establishment of protein localization to Golgi (GO:0072600)3.08009619
68cytoskeletal anchoring at plasma membrane (GO:0007016)3.07565782
69nucleoside transmembrane transport (GO:1901642)3.05468990
70retrograde transport, vesicle recycling within Golgi (GO:0000301)3.04586630
71synaptic vesicle docking involved in exocytosis (GO:0016081)3.00573460
72negative regulation of humoral immune response (GO:0002921)2.98772966
73cerebellar granule cell differentiation (GO:0021707)2.98163246
74dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.96968624
75peptidyl-cysteine modification (GO:0018198)2.96133814
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.95489083
77tachykinin receptor signaling pathway (GO:0007217)2.91321679
78positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.91090433
79COPI coating of Golgi vesicle (GO:0048205)2.91084888
80Golgi transport vesicle coating (GO:0048200)2.91084888
81mitochondrion distribution (GO:0048311)2.88801688
82positive regulation of protein kinase C signaling (GO:0090037)2.88715874
83negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.85987331
84intestinal epithelial cell development (GO:0060576)2.84308123
85insulin-like growth factor receptor signaling pathway (GO:0048009)2.83441241
86establishment or maintenance of bipolar cell polarity (GO:0061245)2.82818555
87establishment or maintenance of apical/basal cell polarity (GO:0035088)2.82818555
88collecting duct development (GO:0072044)2.81956608
89sulfur amino acid catabolic process (GO:0000098)2.80024458
90negative regulation of epidermis development (GO:0045683)2.79004338
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.78606544
92mitochondrion transport along microtubule (GO:0047497)2.78606544
93cell junction maintenance (GO:0034331)2.78404942
94neuronal ion channel clustering (GO:0045161)2.78304481
95regulation of autophagic vacuole assembly (GO:2000785)2.78058695
96protein-DNA complex disassembly (GO:0032986)2.75387191
97nucleosome disassembly (GO:0006337)2.75387191
98protein retention in ER lumen (GO:0006621)2.74981846
99microtubule bundle formation (GO:0001578)2.74543754
100camera-type eye morphogenesis (GO:0048593)2.73788046
101stress granule assembly (GO:0034063)2.72346048
102histone H4 deacetylation (GO:0070933)2.71300514
103valine metabolic process (GO:0006573)2.70912340
104quinone metabolic process (GO:1901661)2.70445092
105positive regulation of smoothened signaling pathway (GO:0045880)2.70173336
106asymmetric protein localization (GO:0008105)2.69858629
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66479345
108negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.66166355
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66024104
110thyroid hormone metabolic process (GO:0042403)2.65249266
111negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.64858617
112regulation of microtubule-based movement (GO:0060632)2.64321414
113vocalization behavior (GO:0071625)2.63690247
114biotin metabolic process (GO:0006768)2.61662151
115histone H3-K9 demethylation (GO:0033169)2.61093130
116vitamin transmembrane transport (GO:0035461)2.60521142
117cardiovascular system development (GO:0072358)2.59986404
118phenylpropanoid metabolic process (GO:0009698)2.59027759
119detection of temperature stimulus involved in sensory perception (GO:0050961)2.58871220
120detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.58871220
121dopamine receptor signaling pathway (GO:0007212)2.58374614
122neural tube development (GO:0021915)2.56412061
123rRNA transcription (GO:0009303)2.56219175
124thyroid gland development (GO:0030878)2.55543882
125cell volume homeostasis (GO:0006884)2.55125025
126phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.54162634
127establishment of mitochondrion localization (GO:0051654)2.53631489
128histone H3 deacetylation (GO:0070932)2.53592569
129regulation of hydrogen peroxide metabolic process (GO:0010310)2.53569350
130non-canonical Wnt signaling pathway (GO:0035567)2.53413073
131gamma-aminobutyric acid transport (GO:0015812)2.53305234
132branching involved in salivary gland morphogenesis (GO:0060445)2.52207761
133establishment of planar polarity (GO:0001736)2.52091261
134establishment of tissue polarity (GO:0007164)2.52091261
135negative regulation of protein activation cascade (GO:2000258)2.51281572
136fatty acid derivative transport (GO:1901571)2.50199112
137icosanoid transport (GO:0071715)2.50199112
138regulation of cytokine production involved in inflammatory response (GO:1900015)2.50099187
139regulation of apoptotic process involved in morphogenesis (GO:1902337)2.49986844
140maternal placenta development (GO:0001893)2.48925264
141establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47961426
142regulation of ARF protein signal transduction (GO:0032012)2.47905969
143positive regulation of digestive system process (GO:0060456)2.47580551
144regulation of chromatin binding (GO:0035561)2.45804171
145branching involved in mammary gland duct morphogenesis (GO:0060444)2.45735062
146vitamin A metabolic process (GO:0006776)2.45448955
147phosphatidylinositol acyl-chain remodeling (GO:0036149)2.45371299
148positive regulation of synapse maturation (GO:0090129)2.44976350
149interferon-gamma production (GO:0032609)2.42580492
150endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.42112303
151establishment of melanosome localization (GO:0032401)2.41738097
152toxin metabolic process (GO:0009404)2.40654569
153adherens junction assembly (GO:0034333)2.40273524
154intracellular estrogen receptor signaling pathway (GO:0030520)2.39701605
155adaptation of signaling pathway (GO:0023058)2.39548533
156central nervous system myelination (GO:0022010)2.38961480
157axon ensheathment in central nervous system (GO:0032291)2.38961480
158regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.38342378
159myelin maintenance (GO:0043217)2.37412197
160histone lysine demethylation (GO:0070076)2.37010704
161regulation of vacuole organization (GO:0044088)2.36771019
162lateral sprouting from an epithelium (GO:0060601)2.34263613
163neutral amino acid transport (GO:0015804)2.33884650
164protein maturation by protein folding (GO:0022417)2.33289027
165regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32601651
166toxin transport (GO:1901998)2.32458298
167melanosome transport (GO:0032402)2.32435717
168metanephric nephron epithelium development (GO:0072243)2.32015068
169primitive streak formation (GO:0090009)2.31988150
170negative regulation of telomerase activity (GO:0051974)2.31815479
171nerve growth factor signaling pathway (GO:0038180)2.31704965
172positive regulation of histone deacetylation (GO:0031065)2.30006466
173atrioventricular valve morphogenesis (GO:0003181)2.29683499
174protein localization to Golgi apparatus (GO:0034067)2.29521244
175phosphatidylserine metabolic process (GO:0006658)2.28040174
176neuron projection extension involved in neuron projection guidance (GO:1902284)2.27686161
177axon extension involved in axon guidance (GO:0048846)2.27686161
178microtubule severing (GO:0051013)2.26907665
179diol metabolic process (GO:0034311)2.26731267
180apoptotic process involved in morphogenesis (GO:0060561)2.26678144
181negative regulation of interleukin-2 production (GO:0032703)2.26573762
182facial nerve structural organization (GO:0021612)2.26279614
183neuron projection regeneration (GO:0031102)2.26259649
184left/right axis specification (GO:0070986)2.25524157
185nucleoside transport (GO:0015858)2.25170318
186macroautophagy (GO:0016236)2.24686703
187establishment of pigment granule localization (GO:0051905)2.24634357
188neural tube closure (GO:0001843)2.24501675
189receptor clustering (GO:0043113)2.24487474
190histone H4-K5 acetylation (GO:0043981)2.23811171
191epithelial cell-cell adhesion (GO:0090136)2.21740728
192metanephric tubule development (GO:0072170)2.21365296
193metanephric nephron tubule development (GO:0072234)2.21365296
194tube closure (GO:0060606)2.20756024
195locomotory exploration behavior (GO:0035641)2.20305617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.77671551
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.04368381
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.04368381
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.04368381
5DROSHA_22980978_ChIP-Seq_HELA_Human2.91717231
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91438500
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.21328148
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.17990880
9TCF7_22412390_ChIP-Seq_EML_Mouse2.02917897
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.02740579
11VDR_21846776_ChIP-Seq_THP-1_Human2.01533333
12STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99186623
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97193176
14CTCF_27219007_Chip-Seq_Bcells_Human1.95347576
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94911424
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.91241546
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89498409
18IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85520144
19* RUNX1_27514584_Chip-Seq_MCF-7_Human1.85485126
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.85197656
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84119450
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82502519
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78329333
24KDM2B_26808549_Chip-Seq_K562_Human1.77230670
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75863059
26LXR_22292898_ChIP-Seq_THP-1_Human1.74575739
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.74247413
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70649781
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69434934
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.67064134
31MYC_22102868_ChIP-Seq_BL_Human1.65773967
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64153578
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59836127
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59836127
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58573027
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58444289
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58151871
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56064460
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55483577
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51785393
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51140811
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49122791
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48984251
44* KDM2B_26808549_Chip-Seq_JURKAT_Human1.45994294
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43614246
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42180856
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41462351
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.40812513
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38346684
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38176700
51ZNF263_19887448_ChIP-Seq_K562_Human1.37413953
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34699556
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33801941
54SMC4_20622854_ChIP-Seq_HELA_Human1.33550029
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32766240
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31948038
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.30932587
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.30394040
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30387918
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30178339
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.29911448
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28986519
63MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.28371976
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26748977
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.26386172
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26073401
67TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23744157
68* RACK7_27058665_Chip-Seq_MCF-7_Human1.23167401
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20372526
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19411432
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18713315
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18553669
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17746302
74PHF8_20622854_ChIP-Seq_HELA_Human1.17140900
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16024826
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15723853
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15427238
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14515161
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.14329421
80E2F1_17053090_ChIP-ChIP_MCF-7_Human1.14309265
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.12100344
82REST_21632747_ChIP-Seq_MESCs_Mouse1.11897830
83OCT4_19829295_ChIP-Seq_ESCs_Human1.10871302
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.10696416
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09874003
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09694385
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09363470
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08870997
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07556766
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06904802
91* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06357736
92SOX3_22085726_ChIP-Seq_NPCs_Mouse1.05323357
93TP53_22127205_ChIP-Seq_IMR90_Human1.05308109
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05040929
95BCL6_27268052_Chip-Seq_Bcells_Human1.04766107
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04383350
97* TP63_22573176_ChIP-Seq_HFKS_Human1.02744647
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.02369193
99CREB1_26743006_Chip-Seq_LNCaP_Human1.02312768
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01839110
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.00877838
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00595189
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00344278
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00144968
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00065165
106EZH2_27304074_Chip-Seq_ESCs_Mouse0.99745107
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99427168
108JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99178462
109TET1_21490601_ChIP-Seq_MESCs_Mouse0.99004206
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98673774
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98648477
112VDR_24763502_ChIP-Seq_THP-1_Human0.98584649
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98431911
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.98331638
115E2F1_20622854_ChIP-Seq_HELA_Human0.98228467
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.98018230
117TP53_23651856_ChIP-Seq_MEFs_Mouse0.97418856
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97325874
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.97211783
120SA1_27219007_Chip-Seq_Bcells_Human0.97049783
121SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96926948
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96844471
123EOMES_21245162_ChIP-Seq_HESCs_Human0.96809199
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.96262643
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.96249651
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95622612
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95529049
128POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94954336
129P68_20966046_ChIP-Seq_HELA_Human0.94906758
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94782669
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94162052
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93930152
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92687965
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91427212
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91291066
136RING1B_27294783_Chip-Seq_ESCs_Mouse0.90381340
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89786926
138* KDM2B_26808549_Chip-Seq_DND41_Human0.88386661
139EZH2_22144423_ChIP-Seq_EOC_Human0.87968658
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.87735533
141CTCF_20526341_ChIP-Seq_ESCs_Human0.87682771
142BCOR_27268052_Chip-Seq_Bcells_Human0.86319854
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.85836118
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.85836118
145NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85669472
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.84693103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.54032544
2MP0002254_reproductive_system_inflammat4.28850174
3MP0002837_dystrophic_cardiac_calcinosis3.49352980
4MP0003183_abnormal_peptide_metabolism3.32183285
5MP0003122_maternal_imprinting3.30544718
6MP0004264_abnormal_extraembryonic_tissu3.19221356
7MP0004043_abnormal_pH_regulation3.18223008
8MP0002249_abnormal_larynx_morphology3.17213883
9MP0009278_abnormal_bone_marrow2.99038463
10MP0003011_delayed_dark_adaptation2.98303067
11MP0002909_abnormal_adrenal_gland2.93583594
12MP0000566_synostosis2.85162669
13MP0000681_abnormal_thyroid_gland2.80644670
14MP0002822_catalepsy2.70070172
15MP0005377_hearing/vestibular/ear_phenot2.58518298
16MP0003878_abnormal_ear_physiology2.58518298
17MP0004133_heterotaxia2.43451360
18MP0010030_abnormal_orbit_morphology2.43067803
19MP0005076_abnormal_cell_differentiation2.25245036
20MP0001348_abnormal_lacrimal_gland2.20791547
21MP0000678_abnormal_parathyroid_gland2.19522278
22MP0000749_muscle_degeneration2.18656938
23MP0008961_abnormal_basal_metabolism2.16418052
24MP0004270_analgesia2.12876806
25MP0000383_abnormal_hair_follicle2.07725420
26MP0002332_abnormal_exercise_endurance2.03583555
27MP0005394_taste/olfaction_phenotype1.94966251
28MP0005499_abnormal_olfactory_system1.94966251
29MP0005409_darkened_coat_color1.86397373
30MP0009384_cardiac_valve_regurgitation1.81245521
31MP0006292_abnormal_olfactory_placode1.75655091
32MP0001502_abnormal_circadian_rhythm1.73212279
33MP0005310_abnormal_salivary_gland1.69079044
34MP0003137_abnormal_impulse_conducting1.61740244
35MP0000537_abnormal_urethra_morphology1.57759201
36MP0006035_abnormal_mitochondrial_morpho1.53842322
37MP0005075_abnormal_melanosome_morpholog1.52377893
38MP0003329_amyloid_beta_deposits1.51512834
39MP0004084_abnormal_cardiac_muscle1.50067849
40MP0001849_ear_inflammation1.49253579
41MP0003890_abnormal_embryonic-extraembry1.47630530
42MP0004859_abnormal_synaptic_plasticity1.44710549
43MP0006082_CNS_inflammation1.44172706
44MP0002269_muscular_atrophy1.42061556
45MP0003705_abnormal_hypodermis_morpholog1.41181976
46MP0004036_abnormal_muscle_relaxation1.36236902
47MP0004145_abnormal_muscle_electrophysio1.34468398
48MP0005623_abnormal_meninges_morphology1.32525460
49MP0003172_abnormal_lysosome_physiology1.32508040
50MP0001984_abnormal_olfaction1.32052331
51MP0002089_abnormal_postnatal_growth/wei1.31614291
52MP0001765_abnormal_ion_homeostasis1.29996363
53MP0000920_abnormal_myelination1.29869801
54MP0002116_abnormal_craniofacial_bone1.26273155
55MP0003942_abnormal_urinary_system1.25407683
56MP0000955_abnormal_spinal_cord1.22946461
57MP0002064_seizures1.22141043
58MP0002653_abnormal_ependyma_morphology1.21547133
59MP0002735_abnormal_chemical_nociception1.21106603
60MP0003635_abnormal_synaptic_transmissio1.20347535
61MP0003861_abnormal_nervous_system1.20172624
62MP0010678_abnormal_skin_adnexa1.19714681
63MP0003136_yellow_coat_color1.17243923
64MP0005330_cardiomyopathy1.16584340
65MP0009780_abnormal_chondrocyte_physiolo1.15835834
66MP0003787_abnormal_imprinting1.14965217
67MP0000026_abnormal_inner_ear1.14882639
68MP0001188_hyperpigmentation1.14655528
69MP0000750_abnormal_muscle_regeneration1.14271424
70MP0002127_abnormal_cardiovascular_syste1.14265802
71MP0005423_abnormal_somatic_nervous1.13082732
72MP0005257_abnormal_intraocular_pressure1.11865188
73MP0004215_abnormal_myocardial_fiber1.10377563
74MP0003283_abnormal_digestive_organ1.09189952
75MP0003634_abnormal_glial_cell1.08832345
76MP0002572_abnormal_emotion/affect_behav1.08160354
77MP0009046_muscle_twitch1.07751753
78MP0009672_abnormal_birth_weight1.07547656
79MP0000604_amyloidosis1.06252505
80MP0002733_abnormal_thermal_nociception1.04484476
81MP0004142_abnormal_muscle_tone1.03513440
82MP0002272_abnormal_nervous_system1.01990345
83MP0005666_abnormal_adipose_tissue1.01785635
84MP0002184_abnormal_innervation1.01122756
85MP0008789_abnormal_olfactory_epithelium1.00768234
86MP0004085_abnormal_heartbeat1.00629875
87MP0000759_abnormal_skeletal_muscle1.00073622
88MP0000003_abnormal_adipose_tissue1.00005404
89MP0000428_abnormal_craniofacial_morphol0.99780171
90MP0002152_abnormal_brain_morphology0.98848946
91MP0003879_abnormal_hair_cell0.98663297
92MP0000462_abnormal_digestive_system0.97497538
93MP0001486_abnormal_startle_reflex0.96192832
94MP0004087_abnormal_muscle_fiber0.95997144
95MP0001270_distended_abdomen0.95214889
96MP0002877_abnormal_melanocyte_morpholog0.95193472
97MP0003115_abnormal_respiratory_system0.94445375
98MP0003075_altered_response_to0.94178902
99MP0003121_genomic_imprinting0.93757083
100MP0000049_abnormal_middle_ear0.92997827
101MP0005058_abnormal_lysosome_morphology0.92025240
102MP0005375_adipose_tissue_phenotype0.91735658
103MP0008569_lethality_at_weaning0.91189297
104MP0001970_abnormal_pain_threshold0.91156464
105MP0004381_abnormal_hair_follicle0.90798531
106MP0003119_abnormal_digestive_system0.88059165
107MP0008260_abnormal_autophagy0.87602476
108MP0002970_abnormal_white_adipose0.86891673
109MP0005397_hematopoietic_system_phenotyp0.86879082
110MP0001545_abnormal_hematopoietic_system0.86879082
111MP0002078_abnormal_glucose_homeostasis0.85738313
112MP0002734_abnormal_mechanical_nocicepti0.84978290
113MP0003690_abnormal_glial_cell0.84607108
114MP0004885_abnormal_endolymph0.84589740
115MP0005266_abnormal_metabolism0.83011801
116MP0002063_abnormal_learning/memory/cond0.82487870
117MP0008875_abnormal_xenobiotic_pharmacok0.81655189
118MP0003123_paternal_imprinting0.80760128
119MP0002876_abnormal_thyroid_physiology0.79514418
120MP0002557_abnormal_social/conspecific_i0.79203502
121MP0002098_abnormal_vibrissa_morphology0.79111549
122MP0000534_abnormal_ureter_morphology0.78800850
123MP0010368_abnormal_lymphatic_system0.78607382
124MP0002092_abnormal_eye_morphology0.78331774
125MP0001963_abnormal_hearing_physiology0.77849864
126MP0002277_abnormal_respiratory_mucosa0.76795802
127MP0003279_aneurysm0.76651082
128MP0010630_abnormal_cardiac_muscle0.76631444
129MP0001485_abnormal_pinna_reflex0.76526273
130MP0001968_abnormal_touch/_nociception0.76119823
131MP0009703_decreased_birth_body0.74660183
132MP0001440_abnormal_grooming_behavior0.73648830
133MP0006138_congestive_heart_failure0.73382608
134MP0009745_abnormal_behavioral_response0.73165684
135MP0005646_abnormal_pituitary_gland0.72791941
136MP0000751_myopathy0.72741607
137MP0004510_myositis0.72409933
138MP0004782_abnormal_surfactant_physiolog0.72000458
139MP0005083_abnormal_biliary_tract0.71197462
140MP0002796_impaired_skin_barrier0.71189238
141MP0000579_abnormal_nail_morphology0.70903688
142MP0005452_abnormal_adipose_tissue0.69989478
143MP0002972_abnormal_cardiac_muscle0.69098590
144MP0002693_abnormal_pancreas_physiology0.68059112
145MP0005535_abnormal_body_temperature0.67772379
146MP0002229_neurodegeneration0.66684409
147MP0002882_abnormal_neuron_morphology0.66131817
148MP0001299_abnormal_eye_distance/0.65317106
149MP0000778_abnormal_nervous_system0.64168302
150MP0006036_abnormal_mitochondrial_physio0.63445092
151MP0000762_abnormal_tongue_morphology0.63426010
152MP0002932_abnormal_joint_morphology0.62979060
153MP0000013_abnormal_adipose_tissue0.62948037
154MP0004185_abnormal_adipocyte_glucose0.62858662
155MP0005379_endocrine/exocrine_gland_phen0.62284882
156MP0005253_abnormal_eye_physiology0.61442683
157MP0004233_abnormal_muscle_weight0.61431416
158MP0005620_abnormal_muscle_contractility0.61393147
159MP0002090_abnormal_vision0.60693794
160MP0002106_abnormal_muscle_physiology0.60577253
161MP0002066_abnormal_motor_capabilities/c0.59484271
162MP0003938_abnormal_ear_development0.59123002
163MP0002752_abnormal_somatic_nervous0.58839635

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.52536505
2Abnormal respiratory epithelium morphology (HP:0012253)5.33009577
3Abnormal respiratory motile cilium morphology (HP:0005938)5.33009577
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.11821937
5Absent/shortened dynein arms (HP:0200106)5.11821937
6Bilateral microphthalmos (HP:0007633)5.02510100
7Obstructive sleep apnea (HP:0002870)4.98639828
8Abnormal ciliary motility (HP:0012262)4.91035045
9Abnormal respiratory motile cilium physiology (HP:0012261)4.83803902
10Hyperinsulinemic hypoglycemia (HP:0000825)4.67463305
11Hepatoblastoma (HP:0002884)4.55729887
12Rhinitis (HP:0012384)4.17697165
13Multiple enchondromatosis (HP:0005701)4.08609946
14Chronic bronchitis (HP:0004469)3.95820117
15Abnormality of the lower motor neuron (HP:0002366)3.78442990
16Broad face (HP:0000283)3.70989383
17Abnormality of liposaccharide metabolism (HP:0010968)3.55326952
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.55326952
19Abnormality of glycolipid metabolism (HP:0010969)3.55326952
20Bronchomalacia (HP:0002780)3.44520103
21Hyperacusis (HP:0010780)3.34385426
22Difficulty running (HP:0009046)3.32257146
23J-shaped sella turcica (HP:0002680)3.32031332
24Failure to thrive in infancy (HP:0001531)3.15473931
25Cervical subluxation (HP:0003308)3.14175151
26Testicular atrophy (HP:0000029)3.06809534
27Atelectasis (HP:0100750)3.05805479
28Supranuclear gaze palsy (HP:0000605)3.03834202
29Generalized hypotonia (HP:0001290)3.02358080
30Bronchiectasis (HP:0002110)3.00587182
31Neoplasm of the heart (HP:0100544)2.98509999
32Hypochromic microcytic anemia (HP:0004840)2.95336454
33Neurofibrillary tangles (HP:0002185)2.92677125
34Ragged-red muscle fibers (HP:0003200)2.90313927
35Partial duplication of thumb phalanx (HP:0009944)2.89543651
36Bell-shaped thorax (HP:0001591)2.86795495
37Lymphangioma (HP:0100764)2.82541806
38Hyperventilation (HP:0002883)2.81640450
39Abnormality of the intrinsic pathway (HP:0010989)2.80935501
40Progressive muscle weakness (HP:0003323)2.78351882
41Abnormality of the nasal mucosa (HP:0000433)2.78072768
42Rib fusion (HP:0000902)2.73435213
43Hand muscle atrophy (HP:0009130)2.72735353
44Stridor (HP:0010307)2.71653816
45Abnormality of the corticospinal tract (HP:0002492)2.70266318
46Abnormality of the salivary glands (HP:0010286)2.67561151
47Hyporeflexia of lower limbs (HP:0002600)2.66611695
48Distal upper limb amyotrophy (HP:0007149)2.62563164
49Upper limb amyotrophy (HP:0009129)2.62563164
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.60353358
51Sleep apnea (HP:0010535)2.56618899
52Achilles tendon contracture (HP:0001771)2.51508053
53Amyotrophic lateral sclerosis (HP:0007354)2.48761333
54Ketoacidosis (HP:0001993)2.48520853
55Hemiparesis (HP:0001269)2.47455963
56Flat acetabular roof (HP:0003180)2.47227480
57Amblyopia (HP:0000646)2.45807924
58Sensory axonal neuropathy (HP:0003390)2.43781638
59Abnormality of the musculature of the hand (HP:0001421)2.41414169
60Abnormal cartilage morphology (HP:0002763)2.39848369
61Partial duplication of the phalanx of hand (HP:0009999)2.38770428
62Villous atrophy (HP:0011473)2.38171409
63Abnormality of small intestinal villus morphology (HP:0011472)2.38171409
64Occipital encephalocele (HP:0002085)2.37010861
65Gout (HP:0001997)2.35838074
66Cerebral inclusion bodies (HP:0100314)2.35392836
67Turricephaly (HP:0000262)2.32669125
68Vitreoretinal degeneration (HP:0000655)2.31924215
69Hypoplasia of the fovea (HP:0007750)2.29588435
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.29588435
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.29302009
72Difficulty walking (HP:0002355)2.28850195
73Nuclear cataract (HP:0100018)2.27512158
74Abnormality of the Achilles tendon (HP:0005109)2.27296432
75EMG: myopathic abnormalities (HP:0003458)2.27295052
76Broad distal phalanx of finger (HP:0009836)2.25578002
77Mildly elevated creatine phosphokinase (HP:0008180)2.24399836
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23052580
79Hyperthyroidism (HP:0000836)2.21676000
80Abnormality of the fingertips (HP:0001211)2.20102268
81Tetraplegia (HP:0002445)2.18873989
82Vaginal fistula (HP:0004320)2.17307732
83Shallow orbits (HP:0000586)2.16867271
84Horizontal nystagmus (HP:0000666)2.16676024
85Myokymia (HP:0002411)2.15751620
86Skin nodule (HP:0200036)2.15518491
87Infertility (HP:0000789)2.14937018
88Rectovaginal fistula (HP:0000143)2.14875676
89Rectal fistula (HP:0100590)2.14875676
90Broad metatarsal (HP:0001783)2.14733294
91Metaphyseal cupping (HP:0003021)2.13369501
92Male infertility (HP:0003251)2.12860390
93Ependymoma (HP:0002888)2.12217317
94Goiter (HP:0000853)2.10663322
95Cerebral aneurysm (HP:0004944)2.08792039
96Anomalous pulmonary venous return (HP:0010772)2.06889305
97Germ cell neoplasia (HP:0100728)2.06318566
98Ventricular tachycardia (HP:0004756)2.01236510
99Deformed sella turcica (HP:0002681)2.00965032
100Resting tremor (HP:0002322)1.98894500
101Thoracic kyphosis (HP:0002942)1.98844151
102Elevated erythrocyte sedimentation rate (HP:0003565)1.98340122
103Thyroid-stimulating hormone excess (HP:0002925)1.97958391
104Abnormality of the dental root (HP:0006486)1.97097748
105Taurodontia (HP:0000679)1.97097748
106Abnormality of permanent molar morphology (HP:0011071)1.97097748
107Bifid tongue (HP:0010297)1.96128750
108Recurrent otitis media (HP:0000403)1.95692715
109Exercise-induced myalgia (HP:0003738)1.95448722
110Ankle clonus (HP:0011448)1.95297543
111Epileptic encephalopathy (HP:0200134)1.95132127
112Malnutrition (HP:0004395)1.93933096
113Increased variability in muscle fiber diameter (HP:0003557)1.93787647
114Abnormality of the thoracic spine (HP:0100711)1.92881770
115Hyperactive renin-angiotensin system (HP:0000841)1.91260164
116Thin bony cortex (HP:0002753)1.89243808
117Abnormality of the fovea (HP:0000493)1.89050041
118Abnormality of the aortic arch (HP:0012303)1.88739744
119Epiphyseal dysplasia (HP:0002656)1.87937854
120Reduced antithrombin III activity (HP:0001976)1.87568392
121Biconcave vertebral bodies (HP:0004586)1.87298770
122Open mouth (HP:0000194)1.87150086
123Intestinal fistula (HP:0100819)1.86955720
124Hypoplastic scapulae (HP:0000882)1.85675044
125Aplasia/Hypoplasia of the scapulae (HP:0006713)1.85675044
126Episodic fever (HP:0001954)1.85573904
127Renal salt wasting (HP:0000127)1.85139940
128Exercise-induced muscle cramps (HP:0003710)1.84183258
129Fused cervical vertebrae (HP:0002949)1.83929215
130Choanal stenosis (HP:0000452)1.82203997
131Genetic anticipation (HP:0003743)1.81646257
132Myoglobinuria (HP:0002913)1.81344969
133Aplastic anemia (HP:0001915)1.80863405
134Spastic gait (HP:0002064)1.80640834
135Visceral angiomatosis (HP:0100761)1.80402886
136Precocious puberty (HP:0000826)1.79789855
137Abnormality of cochlea (HP:0000375)1.79685003
138Abnormality of the dental pulp (HP:0006479)1.79436295
139Nasolacrimal duct obstruction (HP:0000579)1.78892933
140Abnormality of molar morphology (HP:0011070)1.78534919
141Abnormality of molar (HP:0011077)1.78534919
142Diminished motivation (HP:0000745)1.78195024
143Status epilepticus (HP:0002133)1.77907068
144Limb-girdle muscle atrophy (HP:0003797)1.75721965
145Pointed chin (HP:0000307)1.75438718
146Pancreatic islet-cell hyperplasia (HP:0004510)1.74977037
147Tubulointerstitial nephritis (HP:0001970)1.73185622
148Increased connective tissue (HP:0009025)1.72451629
149Abnormal vertebral ossification (HP:0100569)1.71942981
150Ulnar bowing (HP:0003031)1.71499097
151Arnold-Chiari malformation (HP:0002308)1.71244614
152Cystic liver disease (HP:0006706)1.71123221
153Abnormality of glycolysis (HP:0004366)1.71120624
154Increased serum pyruvate (HP:0003542)1.71120624
155Dysostosis multiplex (HP:0000943)1.70804449
156Shawl scrotum (HP:0000049)1.70636908
157Amyloidosis (HP:0011034)1.70388171
158Renovascular hypertension (HP:0100817)1.69930821
159Renal dysplasia (HP:0000110)1.69427635
160Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.68736907
161Aplasia involving bones of the upper limbs (HP:0009823)1.68365503
162Aplasia of the phalanges of the hand (HP:0009802)1.68365503
163Aplasia involving bones of the extremities (HP:0009825)1.68365503
164Hemangiomatosis (HP:0007461)1.66823254
165Macroorchidism (HP:0000053)1.66284071
166Tracheal stenosis (HP:0002777)1.65935677
167EMG: neuropathic changes (HP:0003445)1.65755426
168Polycystic kidney dysplasia (HP:0000113)1.64257028
169Bronchitis (HP:0012387)1.64035119
170Urinary glycosaminoglycan excretion (HP:0003541)1.63734785
171Mucopolysacchariduria (HP:0008155)1.63734785
172Myotonia (HP:0002486)1.62359574
173Supernumerary nipples (HP:0002558)1.62170462
174Overriding aorta (HP:0002623)1.61639585
175Apathy (HP:0000741)1.61611715
176Symptomatic seizures (HP:0011145)1.61537782
177Aplasia/Hypoplasia affecting the retina (HP:0008061)1.61305012
178Type I transferrin isoform profile (HP:0003642)1.61130817
179Nasal polyposis (HP:0100582)1.60432255
180Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59883847
181Elfin facies (HP:0004428)1.59413173
182Hypoplasia of the odontoid process (HP:0003311)1.58362063
183Annular pancreas (HP:0001734)1.57608773
184Spinal canal stenosis (HP:0003416)1.57476275
185Severe Myopia (HP:0011003)1.57053655
186Aortic regurgitation (HP:0001659)1.56078888
187Morphological abnormality of the inner ear (HP:0011390)1.54770598
188Recurrent sinusitis (HP:0011108)1.54308912
189Broad phalanges of the hand (HP:0009768)1.54037966
190Abnormality of mucopolysaccharide metabolism (HP:0011020)1.53912991
191Abnormality of polysaccharide metabolism (HP:0011012)1.53912991
192Abnormality of glycosaminoglycan metabolism (HP:0004371)1.53912991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.39210655
2GRK54.47240713
3CDK123.87151521
4GRK63.36543920
5SMG13.00571163
6EEF2K2.80248096
7TYRO32.73263401
8NTRK12.58352356
9PKN22.56508946
10EPHA22.31932642
11GRK72.22969231
12GRK12.19753172
13ADRBK22.16326431
14WNK12.01948985
15TNK21.96912847
16FGFR41.80081117
17RPS6KA21.79529336
18TRIB31.76746002
19MAP3K61.75524044
20NME11.71239860
21CSF1R1.67798427
22MAPK71.67246309
23FGFR21.65972214
24TGFBR21.56460467
25PHKG11.56361245
26PHKG21.56361245
27BCKDK1.51211919
28MAP3K91.50607198
29MATK1.50338629
30MARK21.45316617
31MOS1.44366761
32ERBB21.38119692
33INSRR1.34994477
34MTOR1.34510330
35CAMK41.28742541
36PRKD21.26902296
37RPS6KC11.24860904
38RPS6KL11.24860904
39EPHB11.22952747
40MAPK121.21467445
41LMTK21.21388726
42NTRK31.20612134
43AKT31.18719314
44DAPK21.17918372
45HIPK21.16901028
46ADRBK11.16534433
47CAMKK11.12936114
48TBK11.12593617
49CDC42BPA1.10437521
50MAP3K71.06688985
51STK391.05979547
52TTN1.04644913
53RPS6KA61.04454891
54PDGFRA1.02148212
55UHMK10.99656868
56MAP2K40.98824103
57PAK30.98448279
58PRKG20.96417740
59TAOK10.94518162
60WNK40.90060272
61PTK20.88953011
62DMPK0.88867320
63PRKCH0.86743027
64SIK10.86016855
65MAP2K30.82668482
66PAK60.82002767
67MAP2K60.79382410
68CDK190.79089206
69RPS6KB20.76864567
70EPHA40.74264191
71ITK0.73396926
72IRAK20.73187289
73KSR20.71844424
74MARK10.69682912
75MAP3K130.65348755
76SGK2230.65060359
77SGK4940.65060359
78MAPKAPK30.63938716
79PKN10.62028049
80TAOK30.61476591
81ROCK20.61038599
82LIMK10.60878105
83TAOK20.60220658
84DYRK1A0.59336200
85NEK60.58948542
86MAPK80.58057408
87RIPK10.57214424
88MAPK150.57185303
89FGFR30.55877180
90ICK0.55477579
91PTK60.55475236
92PAK40.55174976
93MAP3K20.54446893
94CDK50.54144703
95CHUK0.53853083
96MAPK100.53115748
97RPS6KA10.52929978
98LRRK20.52452608
99STK380.52342101
100PRPF4B0.52042214
101OXSR10.51475111
102PRKCZ0.49870618
103SGK30.49530494
104PDPK10.49331039
105PDK10.48594649
106MAP3K10.48234901
107ZAP700.47972761
108STK110.47950586
109RET0.46863484
110MAP3K110.46169888
111CSK0.45923449
112BCR0.45754746
113KDR0.45739272
114BMX0.45618693
115PRKD10.45208254
116NTRK20.45140169
117IKBKE0.44979505
118MYLK0.44880687
119DYRK1B0.43102513
120CAMK1D0.43077083
121JAK20.42951804
122SCYL20.42568121
123TESK10.41824546
124STK100.41588535
125INSR0.41133132
126CAMK1G0.40539997
127IGF1R0.40379237
128MAP2K20.39951879
129FES0.39656660
130MUSK0.39026671
131PRKACG0.38519441
132MAPK30.38421802
133PRKCI0.38390466
134PRKCD0.37767352
135SGK20.37460062
136GSK3B0.36596439
137MAP3K100.36484461
138DYRK20.36333962
139PRKD30.35883183
140LATS20.35701174
141CAMK10.35121600
142ARAF0.35060279
143MAPK10.34154534
144MET0.34015302
145DDR20.33155479
146PDGFRB0.31916705
147PRKACA0.31317062
148PRKAA10.31199001
149CDK150.29616374
150SRC0.29607451
151SIK20.29013519

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.63202246
2Notch signaling pathway_Homo sapiens_hsa043303.20789585
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.46270460
4Vitamin B6 metabolism_Homo sapiens_hsa007502.29094741
5Fructose and mannose metabolism_Homo sapiens_hsa000512.14063308
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84685006
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62242845
8Lysine degradation_Homo sapiens_hsa003101.52710081
9GABAergic synapse_Homo sapiens_hsa047271.50962719
10Axon guidance_Homo sapiens_hsa043601.49157631
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48929579
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47275165
13Other glycan degradation_Homo sapiens_hsa005111.46296014
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.44343612
15Basal cell carcinoma_Homo sapiens_hsa052171.43535232
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.36761531
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35198743
18Vibrio cholerae infection_Homo sapiens_hsa051101.34412092
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.34129894
20Sulfur metabolism_Homo sapiens_hsa009201.33985585
21Tight junction_Homo sapiens_hsa045301.31780059
22Arachidonic acid metabolism_Homo sapiens_hsa005901.30863002
23Linoleic acid metabolism_Homo sapiens_hsa005911.29834140
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29674975
25Acute myeloid leukemia_Homo sapiens_hsa052211.28346550
26Endometrial cancer_Homo sapiens_hsa052131.28289943
27Insulin secretion_Homo sapiens_hsa049111.28052869
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27977690
29Lysosome_Homo sapiens_hsa041421.27328776
30Melanogenesis_Homo sapiens_hsa049161.25950473
31Estrogen signaling pathway_Homo sapiens_hsa049151.25020372
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22162177
33Glutamatergic synapse_Homo sapiens_hsa047241.20189841
34Histidine metabolism_Homo sapiens_hsa003401.20121183
35Cardiac muscle contraction_Homo sapiens_hsa042601.19281503
36Chronic myeloid leukemia_Homo sapiens_hsa052201.18994307
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17746155
38Dilated cardiomyopathy_Homo sapiens_hsa054141.16983109
39Synaptic vesicle cycle_Homo sapiens_hsa047211.16032330
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.15460015
41Galactose metabolism_Homo sapiens_hsa000521.14742745
42Protein export_Homo sapiens_hsa030601.11733552
43Tryptophan metabolism_Homo sapiens_hsa003801.11480702
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.09996093
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07208697
46ABC transporters_Homo sapiens_hsa020101.07047862
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07045115
48Ether lipid metabolism_Homo sapiens_hsa005651.06801106
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.03349879
50Hippo signaling pathway_Homo sapiens_hsa043901.02031305
51AMPK signaling pathway_Homo sapiens_hsa041521.01665893
52Pancreatic secretion_Homo sapiens_hsa049721.00984582
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00333303
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97253950
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96958656
56Insulin signaling pathway_Homo sapiens_hsa049100.93536617
57Serotonergic synapse_Homo sapiens_hsa047260.93073810
58Glioma_Homo sapiens_hsa052140.91009952
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90903080
60Hedgehog signaling pathway_Homo sapiens_hsa043400.89951978
61Long-term potentiation_Homo sapiens_hsa047200.89897710
62Non-small cell lung cancer_Homo sapiens_hsa052230.89679843
63Taste transduction_Homo sapiens_hsa047420.89032923
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87604358
65Phenylalanine metabolism_Homo sapiens_hsa003600.86876330
66Nitrogen metabolism_Homo sapiens_hsa009100.85748137
67Collecting duct acid secretion_Homo sapiens_hsa049660.85284291
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.84991594
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.83868632
70ECM-receptor interaction_Homo sapiens_hsa045120.81715725
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81620554
72VEGF signaling pathway_Homo sapiens_hsa043700.81492918
73Prolactin signaling pathway_Homo sapiens_hsa049170.80985173
74Steroid biosynthesis_Homo sapiens_hsa001000.80778258
75Salivary secretion_Homo sapiens_hsa049700.80482162
76Choline metabolism in cancer_Homo sapiens_hsa052310.80082240
77Adherens junction_Homo sapiens_hsa045200.78323521
78Wnt signaling pathway_Homo sapiens_hsa043100.77779132
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.77529259
80Circadian entrainment_Homo sapiens_hsa047130.77495240
81Dopaminergic synapse_Homo sapiens_hsa047280.76461891
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74020235
83Sulfur relay system_Homo sapiens_hsa041220.73729041
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73490564
85Oxidative phosphorylation_Homo sapiens_hsa001900.73395923
86Tyrosine metabolism_Homo sapiens_hsa003500.71959969
87Calcium signaling pathway_Homo sapiens_hsa040200.71575775
88Thyroid hormone synthesis_Homo sapiens_hsa049180.71314099
89Hepatitis C_Homo sapiens_hsa051600.71215713
90Cholinergic synapse_Homo sapiens_hsa047250.71161775
91Bladder cancer_Homo sapiens_hsa052190.70903809
92Prostate cancer_Homo sapiens_hsa052150.70757709
93MAPK signaling pathway_Homo sapiens_hsa040100.70748970
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70201814
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69797663
96GnRH signaling pathway_Homo sapiens_hsa049120.69486073
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69086545
98Focal adhesion_Homo sapiens_hsa045100.69047767
99mTOR signaling pathway_Homo sapiens_hsa041500.68658144
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66843471
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66658958
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66559752
103Butanoate metabolism_Homo sapiens_hsa006500.66318412
104Ovarian steroidogenesis_Homo sapiens_hsa049130.66278064
105cAMP signaling pathway_Homo sapiens_hsa040240.66176275
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65368066
107Nicotine addiction_Homo sapiens_hsa050330.64603207
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64570341
109Cocaine addiction_Homo sapiens_hsa050300.64449966
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.64183812
111Colorectal cancer_Homo sapiens_hsa052100.63819366
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63024990
113Thyroid cancer_Homo sapiens_hsa052160.62540080
114Ras signaling pathway_Homo sapiens_hsa040140.62111165
115Glucagon signaling pathway_Homo sapiens_hsa049220.60837520
116Gap junction_Homo sapiens_hsa045400.60786776
117Oxytocin signaling pathway_Homo sapiens_hsa049210.60698846
118Endocytosis_Homo sapiens_hsa041440.60506598
119Inositol phosphate metabolism_Homo sapiens_hsa005620.60347491
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59861653
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59262563
122Prion diseases_Homo sapiens_hsa050200.58525585
123Amoebiasis_Homo sapiens_hsa051460.58501536
124Gastric acid secretion_Homo sapiens_hsa049710.56680877
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56255045
126Alzheimers disease_Homo sapiens_hsa050100.56080192
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55858282
128Regulation of autophagy_Homo sapiens_hsa041400.54358686
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54096249
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54086970
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53066784
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52953325
133Long-term depression_Homo sapiens_hsa047300.52596243
134Morphine addiction_Homo sapiens_hsa050320.52414230
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.51526724
136Renin secretion_Homo sapiens_hsa049240.50332072
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49557398
138ErbB signaling pathway_Homo sapiens_hsa040120.49049859
139Insulin resistance_Homo sapiens_hsa049310.48988112
140Rap1 signaling pathway_Homo sapiens_hsa040150.48587894
141Sphingolipid metabolism_Homo sapiens_hsa006000.48498948
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47907272
143Type II diabetes mellitus_Homo sapiens_hsa049300.47712135
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.47357410
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47073147
146Fatty acid degradation_Homo sapiens_hsa000710.46151314
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45790798
148Fatty acid elongation_Homo sapiens_hsa000620.45457389
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44528708
150Fatty acid metabolism_Homo sapiens_hsa012120.44465728
151Amphetamine addiction_Homo sapiens_hsa050310.42961161

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