SLC25A25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.12173628
2L-phenylalanine catabolic process (GO:0006559)7.12173628
3L-phenylalanine metabolic process (GO:0006558)6.80081620
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80081620
5aromatic amino acid family catabolic process (GO:0009074)6.31169796
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.84670981
7tryptophan catabolic process (GO:0006569)5.63000380
8indole-containing compound catabolic process (GO:0042436)5.63000380
9indolalkylamine catabolic process (GO:0046218)5.63000380
10kynurenine metabolic process (GO:0070189)5.53254840
11bile acid biosynthetic process (GO:0006699)5.48030641
12glyoxylate metabolic process (GO:0046487)5.37103406
13alpha-linolenic acid metabolic process (GO:0036109)5.36815015
14urea cycle (GO:0000050)5.34528303
15urea metabolic process (GO:0019627)5.34528303
16tryptophan metabolic process (GO:0006568)5.31667018
17high-density lipoprotein particle remodeling (GO:0034375)5.22207998
18cysteine metabolic process (GO:0006534)5.20282437
19sulfur amino acid catabolic process (GO:0000098)5.14741215
20negative regulation of fibrinolysis (GO:0051918)5.06195019
21regulation of cholesterol esterification (GO:0010872)5.05707833
22regulation of fibrinolysis (GO:0051917)5.01096599
23serine family amino acid catabolic process (GO:0009071)4.92727924
24nitrogen cycle metabolic process (GO:0071941)4.90107361
25regulation of protein activation cascade (GO:2000257)4.87332912
26peptidyl-glutamic acid carboxylation (GO:0017187)4.85989369
27protein carboxylation (GO:0018214)4.85989369
28complement activation, alternative pathway (GO:0006957)4.83780845
29response to nitrosative stress (GO:0051409)4.71317180
30bile acid metabolic process (GO:0008206)4.70038272
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.63547410
32aromatic amino acid family metabolic process (GO:0009072)4.61114241
33reverse cholesterol transport (GO:0043691)4.60953962
34homocysteine metabolic process (GO:0050667)4.59335883
35regulation of complement activation (GO:0030449)4.53791314
36tyrosine metabolic process (GO:0006570)4.53349264
37lysine catabolic process (GO:0006554)4.47933303
38lysine metabolic process (GO:0006553)4.47933303
39regulation of triglyceride catabolic process (GO:0010896)4.46843241
40protein-lipid complex remodeling (GO:0034368)4.44795660
41macromolecular complex remodeling (GO:0034367)4.44795660
42plasma lipoprotein particle remodeling (GO:0034369)4.44795660
43benzene-containing compound metabolic process (GO:0042537)4.43857535
44triglyceride homeostasis (GO:0070328)4.42768086
45acylglycerol homeostasis (GO:0055090)4.42768086
46alpha-amino acid catabolic process (GO:1901606)4.35780558
47amino-acid betaine metabolic process (GO:0006577)4.30981596
48cellular glucuronidation (GO:0052695)4.29446161
49negative regulation of sterol transport (GO:0032372)4.27100542
50negative regulation of cholesterol transport (GO:0032375)4.27100542
51glutamate metabolic process (GO:0006536)4.26622178
52phospholipid efflux (GO:0033700)4.26009230
53xenobiotic catabolic process (GO:0042178)4.18951966
54cellular ketone body metabolic process (GO:0046950)4.17158092
55drug catabolic process (GO:0042737)4.09042351
56regulation of cholesterol homeostasis (GO:2000188)4.06168270
57cellular amino acid catabolic process (GO:0009063)4.05484018
58plasma lipoprotein particle clearance (GO:0034381)4.02932575
59coenzyme catabolic process (GO:0009109)4.02900669
60indolalkylamine metabolic process (GO:0006586)4.02437657
61regulation of bile acid biosynthetic process (GO:0070857)4.01449667
62bile acid and bile salt transport (GO:0015721)3.99960084
63cholesterol efflux (GO:0033344)3.97148548
64dicarboxylic acid biosynthetic process (GO:0043650)3.96563504
65serine family amino acid metabolic process (GO:0009069)3.94724850
66cellular modified amino acid catabolic process (GO:0042219)3.90322215
67glycine metabolic process (GO:0006544)3.86804260
68glucuronate metabolic process (GO:0019585)3.84782424
69uronic acid metabolic process (GO:0006063)3.84782424
70positive regulation of p38MAPK cascade (GO:1900745)3.82482059
71amine catabolic process (GO:0009310)3.80696450
72cellular biogenic amine catabolic process (GO:0042402)3.80696450
73activation of MAPKKK activity (GO:0000185)3.77175395
74arginine metabolic process (GO:0006525)3.72911401
75omega-hydroxylase P450 pathway (GO:0097267)3.72789217
76epoxygenase P450 pathway (GO:0019373)3.71173673
77phospholipid homeostasis (GO:0055091)3.70151355
78positive regulation of lipid catabolic process (GO:0050996)3.70020889
79serine family amino acid biosynthetic process (GO:0009070)3.69522083
80imidazole-containing compound metabolic process (GO:0052803)3.69397055
81fibrinolysis (GO:0042730)3.64340643
82exogenous drug catabolic process (GO:0042738)3.63859063
83low-density lipoprotein particle remodeling (GO:0034374)3.63613847
84urate metabolic process (GO:0046415)3.63298590
85plasma lipoprotein particle assembly (GO:0034377)3.62685717
86cholesterol homeostasis (GO:0042632)3.61851103
87negative regulation of lipase activity (GO:0060192)3.59232688
88ketone body metabolic process (GO:1902224)3.57824864
89sterol homeostasis (GO:0055092)3.57000207
90drug transmembrane transport (GO:0006855)3.56942391
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.52998079
92carboxylic acid catabolic process (GO:0046395)3.52921488
93organic acid catabolic process (GO:0016054)3.52921488
94ethanol oxidation (GO:0006069)3.50869159
95regulation of p38MAPK cascade (GO:1900744)3.49669520
96positive regulation of lipoprotein lipase activity (GO:0051006)3.44449378
97positive regulation of triglyceride lipase activity (GO:0061365)3.44449378
98aldehyde catabolic process (GO:0046185)3.43644860
99acetyl-CoA metabolic process (GO:0006084)3.43623870
1002-oxoglutarate metabolic process (GO:0006103)3.40085100
101acute-phase response (GO:0006953)3.39941793
102drug metabolic process (GO:0017144)3.38374036
103short-chain fatty acid metabolic process (GO:0046459)3.35918727
104very-low-density lipoprotein particle assembly (GO:0034379)3.34986254
105complement activation, classical pathway (GO:0006958)3.34426557
106positive regulation of fatty acid biosynthetic process (GO:0045723)3.18487177
107response to mercury ion (GO:0046689)3.15958629
108regulation of plasminogen activation (GO:0010755)3.11826493
109sodium ion export (GO:0071436)3.10154684
110regulation of cholesterol biosynthetic process (GO:0045540)3.05422578
111regulation of fatty acid biosynthetic process (GO:0042304)3.01531768
112negative regulation of fatty acid biosynthetic process (GO:0045717)2.93462568
113complement activation (GO:0006956)2.91793746
114regulation of glucose import in response to insulin stimulus (GO:2001273)2.86091320
115protein activation cascade (GO:0072376)2.85201245
116atrioventricular valve morphogenesis (GO:0003181)2.83972320
117negative regulation of lipid transport (GO:0032369)2.79526359
118tooth mineralization (GO:0034505)2.79447945
119opsonization (GO:0008228)2.69812967
120cell-cell junction maintenance (GO:0045217)2.69071922
121activation of protein kinase A activity (GO:0034199)2.66637737
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.65907892
123negative regulation of fatty acid transport (GO:2000192)2.65114181
124regulation of humoral immune response (GO:0002920)2.63150309
125regulation of T-helper 2 cell differentiation (GO:0045628)2.60843163
126cAMP biosynthetic process (GO:0006171)2.60424188
127endothelial cell chemotaxis (GO:0035767)2.59439407
128blood coagulation, intrinsic pathway (GO:0007597)2.57928817
129regulation of cholesterol metabolic process (GO:0090181)2.56721309
130positive regulation of triglyceride metabolic process (GO:0090208)2.53833442
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.50671020
132cellular potassium ion homeostasis (GO:0030007)2.50182029
133positive regulation of cholesterol efflux (GO:0010875)2.46553448
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.44288444
135positive regulation of hemostasis (GO:1900048)2.44038723
136positive regulation of blood coagulation (GO:0030194)2.44038723
137gas transport (GO:0015669)2.42823374
138intestinal cholesterol absorption (GO:0030299)2.42155378
139positive regulation of cellular amide metabolic process (GO:0034250)2.41731719
140response to laminar fluid shear stress (GO:0034616)2.38434012
141cellular sodium ion homeostasis (GO:0006883)2.38068656
142surfactant homeostasis (GO:0043129)2.37498513
143fructose metabolic process (GO:0006000)2.35922730
144negative regulation of blood coagulation (GO:0030195)2.35633389
145negative regulation of hemostasis (GO:1900047)2.35633389
146positive regulation of coagulation (GO:0050820)2.32616865
147oxygen transport (GO:0015671)2.31432870
148cerebellar granule cell differentiation (GO:0021707)2.30258976
149proline metabolic process (GO:0006560)2.29047395
150hyaluronan metabolic process (GO:0030212)2.28935890
151phosphate ion transmembrane transport (GO:0035435)2.28887140
152regulation of apoptotic cell clearance (GO:2000425)2.28800238
153embryonic process involved in female pregnancy (GO:0060136)2.26714435
154gluconeogenesis (GO:0006094)2.26641977
155regulation of lipid catabolic process (GO:0050994)2.26427677
156creatine metabolic process (GO:0006600)2.25962668
157adherens junction assembly (GO:0034333)2.25906484
158positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25843172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.44592944
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.33602581
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.85358894
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.54615291
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.90023617
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.23469483
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.96915105
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.88857630
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15247844
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.01655092
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.50120410
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.34704824
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28022707
14VDR_21846776_ChIP-Seq_THP-1_Human2.21888302
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.10231794
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.05574224
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02214115
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3674368
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98079552
20KDM2B_26808549_Chip-Seq_DND41_Human1.95427806
21* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90603988
22TCF7_22412390_ChIP-Seq_EML_Mouse1.89199626
23* CLOCK_20551151_ChIP-Seq_293T_Human1.87474659
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.79021673
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77906727
26* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75294712
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72329983
28SMC4_20622854_ChIP-Seq_HELA_Human1.66042701
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62822996
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.60358752
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55030763
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.49575722
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47136277
34P68_20966046_ChIP-Seq_HELA_Human1.46717371
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.45637211
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43662096
37MYC_22102868_ChIP-Seq_BL_Human1.43571623
38* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42125617
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38948035
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36355008
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35848305
42* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35828382
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34435818
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.32493240
45ZNF263_19887448_ChIP-Seq_K562_Human1.29560223
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.28920532
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27804709
48* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24767726
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.24000259
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22784525
51* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22626023
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.22089109
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20497653
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19834086
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16814016
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16576589
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16301457
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16247290
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16085927
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.15963586
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13835691
62MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13025073
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12947264
64TP53_22127205_ChIP-Seq_IMR90_Human1.12718067
65HTT_18923047_ChIP-ChIP_STHdh_Human1.11790077
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09852643
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09852643
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09365424
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08807427
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08670807
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08566209
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08347279
73* ATF3_27146783_Chip-Seq_COLON_Human1.05393895
74SA1_27219007_Chip-Seq_Bcells_Human1.05182297
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05130773
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.04675232
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03386245
78GATA1_22025678_ChIP-Seq_K562_Human1.01815792
79VDR_24763502_ChIP-Seq_THP-1_Human1.00218797
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99409574
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98905436
82RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98064075
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96841143
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96206514
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.94898590
86* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94433460
87TP63_22573176_ChIP-Seq_HFKS_Human0.94055246
88BCOR_27268052_Chip-Seq_Bcells_Human0.93981752
89SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93971924
90TBX20_22080862_ChIP-Seq_HEART_Mouse0.92484367
91TBX20_22328084_ChIP-Seq_HEART_Mouse0.92484367
92ESR1_21235772_ChIP-Seq_MCF-7_Human0.92294694
93* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92139221
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91414859
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86981008
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86566010
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86566010
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84383818
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.83998610
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82993953
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81392962
102TAF15_26573619_Chip-Seq_HEK293_Human0.81060419
103* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79900709
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79377474
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74802272
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74161760
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72385848
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72265614
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72264382
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71006363
111GATA4_25053715_ChIP-Seq_YYC3_Human0.70321442
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.69665011
113* LXR_22292898_ChIP-Seq_THP-1_Human0.69537826
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.69487691
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69093955
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68717439
117* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.68099380
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66379894
119EGR1_19032775_ChIP-ChIP_M12_Human0.63222056
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61352409
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.60524044
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60146103
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.59770737
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.59522663
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.59467323
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.59033486
127* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58755627
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.57766577
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57247906
130BCAT_22108803_ChIP-Seq_LS180_Human0.56795108
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55905598
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.55696017
133CTCF_27219007_Chip-Seq_Bcells_Human0.55680208
134* CREB1_26743006_Chip-Seq_LNCaP_Human0.55141327
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.54761297
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.54651099
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.54599857
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.53474090
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52754852
140RACK7_27058665_Chip-Seq_MCF-7_Human0.50436435
141DROSHA_22980978_ChIP-Seq_HELA_Human0.50304519
142* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50140763
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.49986350
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.49695759
145GATA1_19941826_ChIP-Seq_K562_Human0.49455700
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.48423807
147MYC_19915707_ChIP-ChIP_AK7_Human0.47891576
148BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.47669704
149RARB_24833708_ChIP-Seq_LIVER_Mouse0.47655635
150KDM2B_26808549_Chip-Seq_K562_Human0.46124782
151KLF4_19829295_ChIP-Seq_ESCs_Human0.45729391
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.45584533
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.45463245
154KAP1_22055183_ChIP-Seq_ESCs_Mouse0.45351146
155MTF2_20144788_ChIP-Seq_MESCs_Mouse0.45319720
156AHR_22903824_ChIP-Seq_MCF-7_Human0.45233095
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44609819
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44541750
159GATA2_19941826_ChIP-Seq_K562_Human0.44504116
160CBP_21632823_ChIP-Seq_H3396_Human0.44495088
161RXR_22108803_ChIP-Seq_LS180_Human0.43963451
162GATA6_25053715_ChIP-Seq_YYC3_Human0.43672383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.03521792
2MP0005360_urolithiasis7.39630792
3MP0005085_abnormal_gallbladder_physiolo6.21008176
4MP0005365_abnormal_bile_salt6.02999442
5MP0008875_abnormal_xenobiotic_pharmacok5.43806428
6MP0003252_abnormal_bile_duct3.91489986
7MP0010329_abnormal_lipoprotein_level3.58107712
8MP0009840_abnormal_foam_cell3.28621986
9MP0003806_abnormal_nucleotide_metabolis3.21858246
10MP0005083_abnormal_biliary_tract3.02827089
11MP0005332_abnormal_amino_acid2.89472339
12MP0003195_calcinosis2.76754675
13MP0003879_abnormal_hair_cell2.69919825
14MP0001666_abnormal_nutrient_absorption2.38932548
15MP0004019_abnormal_vitamin_homeostasis2.38399427
16MP0005423_abnormal_somatic_nervous2.37744650
17MP0003191_abnormal_cellular_cholesterol2.33228073
18MP0005058_abnormal_lysosome_morphology2.17493430
19MP0004859_abnormal_synaptic_plasticity2.14111148
20MP0002118_abnormal_lipid_homeostasis2.11134407
21MP0002138_abnormal_hepatobiliary_system2.07834431
22MP0000609_abnormal_liver_physiology2.06428160
23MP0001502_abnormal_circadian_rhythm1.92935480
24MP0000751_myopathy1.81180020
25MP0003303_peritoneal_inflammation1.77653266
26MP0003453_abnormal_keratinocyte_physiol1.71598036
27MP0005319_abnormal_enzyme/_coenzyme1.71174763
28MP0004233_abnormal_muscle_weight1.68607361
29MP0004858_abnormal_nervous_system1.65272157
30MP0003868_abnormal_feces_composition1.61871767
31MP0005076_abnormal_cell_differentiation1.61170058
32MP0002249_abnormal_larynx_morphology1.60378713
33MP0001764_abnormal_homeostasis1.59841411
34MP0005409_darkened_coat_color1.58184441
35MP0002254_reproductive_system_inflammat1.49583551
36MP0005584_abnormal_enzyme/coenzyme_acti1.48959934
37MP0000747_muscle_weakness1.48902430
38MP0004270_analgesia1.45200383
39MP0004510_myositis1.40353241
40MP0003705_abnormal_hypodermis_morpholog1.38179133
41MP0005375_adipose_tissue_phenotype1.31728503
42MP0003011_delayed_dark_adaptation1.30610649
43MP0005451_abnormal_body_composition1.30291038
44MP0009643_abnormal_urine_homeostasis1.30243908
45MP0003091_abnormal_cell_migration1.30240084
46MP0000003_abnormal_adipose_tissue1.28304425
47MP0000759_abnormal_skeletal_muscle1.24609194
48MP0004185_abnormal_adipocyte_glucose1.23896828
49MP0004947_skin_inflammation1.15636490
50MP0004087_abnormal_muscle_fiber1.14346290
51MP0001348_abnormal_lacrimal_gland1.12906676
52MP0000604_amyloidosis1.12419155
53MP0000678_abnormal_parathyroid_gland1.10504450
54MP0003186_abnormal_redox_activity1.09122271
55MP0000598_abnormal_liver_morphology1.04170862
56MP0009697_abnormal_copulation1.01824251
57MP0004043_abnormal_pH_regulation1.00542181
58MP0003656_abnormal_erythrocyte_physiolo1.00148087
59MP0009764_decreased_sensitivity_to0.99583940
60MP0001958_emphysema0.99272055
61MP0000750_abnormal_muscle_regeneration0.97577066
62MP0005647_abnormal_sex_gland0.97509190
63MP0003690_abnormal_glial_cell0.96901765
64MP0000733_abnormal_muscle_development0.94374714
65MP0005535_abnormal_body_temperature0.93317765
66MP0003634_abnormal_glial_cell0.92830726
67MP0010368_abnormal_lymphatic_system0.90924673
68MP0005636_abnormal_mineral_homeostasis0.90076018
69MP0005670_abnormal_white_adipose0.89012246
70MP0005501_abnormal_skin_physiology0.88709940
71MP0003566_abnormal_cell_adhesion0.88119049
72MP0003329_amyloid_beta_deposits0.87520153
73MP0009278_abnormal_bone_marrow0.87421886
74MP0003635_abnormal_synaptic_transmissio0.86976070
75MP0004130_abnormal_muscle_cell0.86767841
76MP0002078_abnormal_glucose_homeostasis0.86624088
77MP0009763_increased_sensitivity_to0.86374690
78MP0004264_abnormal_extraembryonic_tissu0.85233643
79MP0001756_abnormal_urination0.84911939
80MP0005084_abnormal_gallbladder_morpholo0.83972797
81MP0008260_abnormal_autophagy0.83575906
82MP0005023_abnormal_wound_healing0.83054938
83MP0002971_abnormal_brown_adipose0.81689754
84MP0009642_abnormal_blood_homeostasis0.81351087
85MP0008569_lethality_at_weaning0.78494892
86MP0001849_ear_inflammation0.78322518
87MP0005257_abnormal_intraocular_pressure0.77902007
88MP0002876_abnormal_thyroid_physiology0.77678845
89MP0002998_abnormal_bone_remodeling0.77345030
90MP0001188_hyperpigmentation0.77318465
91MP0000013_abnormal_adipose_tissue0.77144864
92MP0002269_muscular_atrophy0.74955122
93MP0005377_hearing/vestibular/ear_phenot0.73922715
94MP0003878_abnormal_ear_physiology0.73922715
95MP0005376_homeostasis/metabolism_phenot0.73678791
96MP0002822_catalepsy0.73582994
97MP0005334_abnormal_fat_pad0.72975354
98MP0003828_pulmonary_edema0.72710176
99MP0002063_abnormal_learning/memory/cond0.72103390
100MP0008872_abnormal_physiological_respon0.70872675
101MP0003436_decreased_susceptibility_to0.70055916
102MP0010630_abnormal_cardiac_muscle0.69282539
103MP0009053_abnormal_anal_canal0.69057387
104MP0000749_muscle_degeneration0.68854724
105MP0001915_intracranial_hemorrhage0.68690207
106MP0004145_abnormal_muscle_electrophysio0.68658037
107MP0008469_abnormal_protein_level0.68624776
108MP0005408_hypopigmentation0.68506652
109MP0000343_altered_response_to0.67866528
110MP0002089_abnormal_postnatal_growth/wei0.67299872
111MP0009765_abnormal_xenobiotic_induced0.66613621
112MP0002090_abnormal_vision0.66450105
113MP0002064_seizures0.66129824
114MP0004272_abnormal_basement_membrane0.65800001
115MP0005448_abnormal_energy_balance0.62466608
116MP0002928_abnormal_bile_duct0.61185321
117MP0003075_altered_response_to0.61169788
118MP0005220_abnormal_exocrine_pancreas0.60807955
119MP0008961_abnormal_basal_metabolism0.58293286
120MP0005266_abnormal_metabolism0.56981602
121MP0006036_abnormal_mitochondrial_physio0.56919754
122MP0002136_abnormal_kidney_physiology0.55222531
123MP0005187_abnormal_penis_morphology0.53657958
124MP0005166_decreased_susceptibility_to0.52960777
125MP0004883_abnormal_blood_vessel0.50343735
126MP0003953_abnormal_hormone_level0.50336962
127MP0000639_abnormal_adrenal_gland0.50167533
128MP0008874_decreased_physiological_sensi0.49127869
129MP0003724_increased_susceptibility_to0.45869799
130MP0001501_abnormal_sleep_pattern0.44627429
131MP0005666_abnormal_adipose_tissue0.43612511
132MP0005551_abnormal_eye_electrophysiolog0.43504287
133MP0003638_abnormal_response/metabolism_0.43096873
134MP0002909_abnormal_adrenal_gland0.42823969
135MP0001661_extended_life_span0.41779081
136MP0002168_other_aberrant_phenotype0.41606668
137MP0005395_other_phenotype0.41556640
138MP0009780_abnormal_chondrocyte_physiolo0.40814951
139MP0006035_abnormal_mitochondrial_morpho0.40085932
140MP0008873_increased_physiological_sensi0.40073450
141MP0005248_abnormal_Harderian_gland0.39889924
142MP0005167_abnormal_blood-brain_barrier0.39361070
143MP0009115_abnormal_fat_cell0.39233302
144MP0002796_impaired_skin_barrier0.38395115
145MP0000230_abnormal_systemic_arterial0.37936378
146MP0010234_abnormal_vibrissa_follicle0.37688111
147MP0009672_abnormal_birth_weight0.37574603
148MP0005164_abnormal_response_to0.36067106
149MP0003633_abnormal_nervous_system0.35512996
150MP0002332_abnormal_exercise_endurance0.35403396
151MP0000579_abnormal_nail_morphology0.35187969
152MP0003300_gastrointestinal_ulcer0.34744864
153MP0001765_abnormal_ion_homeostasis0.32909703
154MP0004782_abnormal_surfactant_physiolog0.31177873
155MP0005464_abnormal_platelet_physiology0.30943450
156MP0002837_dystrophic_cardiac_calcinosis0.30552702

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.12837789
2Deep venous thrombosis (HP:0002625)6.91976902
3Intrahepatic cholestasis (HP:0001406)6.69733821
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60393975
5Xanthomatosis (HP:0000991)6.33881133
6Hypobetalipoproteinemia (HP:0003563)5.89893249
7Prolonged partial thromboplastin time (HP:0003645)5.79280030
8Hyperlipoproteinemia (HP:0010980)5.24859946
9Complement deficiency (HP:0004431)5.02058418
10Hypolipoproteinemia (HP:0010981)4.60668378
11Epidermoid cyst (HP:0200040)4.57466104
12Hyperammonemia (HP:0001987)4.39665706
13Hyperglycinemia (HP:0002154)4.34890453
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32417582
15Joint hemorrhage (HP:0005261)4.30182644
16Hypoalphalipoproteinemia (HP:0003233)4.27138598
17Ketosis (HP:0001946)4.25482346
18Abnormality of the common coagulation pathway (HP:0010990)4.16678467
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13651625
20Hyperglycinuria (HP:0003108)4.09530216
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.02076928
22Fat malabsorption (HP:0002630)3.93167136
23Abnormality of glycine metabolism (HP:0010895)3.90554040
24Abnormality of serine family amino acid metabolism (HP:0010894)3.90554040
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.80444568
26Hypoglycemic coma (HP:0001325)3.69009118
27Abnormality of methionine metabolism (HP:0010901)3.66668338
28Abnormality of complement system (HP:0005339)3.64888702
29Gout (HP:0001997)3.51971003
30Hypercholesterolemia (HP:0003124)3.44794766
31Conjugated hyperbilirubinemia (HP:0002908)3.38380019
32Abnormality of the intrinsic pathway (HP:0010989)3.35800311
33Abnormality of pyrimidine metabolism (HP:0004353)3.27616931
34Ketoacidosis (HP:0001993)3.24822926
35Abnormality of fatty-acid metabolism (HP:0004359)3.17859614
36Abnormality of nucleobase metabolism (HP:0010932)3.13588035
37Abnormality of purine metabolism (HP:0004352)3.06573588
38Myocardial infarction (HP:0001658)3.03804665
39Hepatocellular carcinoma (HP:0001402)3.01449298
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00283605
41Neurofibrillary tangles (HP:0002185)2.96249688
42Exercise-induced myalgia (HP:0003738)2.94865098
43Spontaneous abortion (HP:0005268)2.91395647
44Hyperbilirubinemia (HP:0002904)2.91377369
45Steatorrhea (HP:0002570)2.89221191
46Abnormality of serum amino acid levels (HP:0003112)2.85403923
47Increased connective tissue (HP:0009025)2.85142382
48Distal lower limb muscle weakness (HP:0009053)2.84387826
49Delayed CNS myelination (HP:0002188)2.83007860
50Myopathic facies (HP:0002058)2.81014082
51Cerebral inclusion bodies (HP:0100314)2.79803478
52Skin nodule (HP:0200036)2.79322486
53Distal lower limb amyotrophy (HP:0008944)2.74806479
54Ulnar bowing (HP:0003031)2.71674434
55Metabolic acidosis (HP:0001942)2.71015119
56Obstructive sleep apnea (HP:0002870)2.70909030
57Achilles tendon contracture (HP:0001771)2.69214257
58Systemic lupus erythematosus (HP:0002725)2.66723243
59Segmental peripheral demyelination/remyelination (HP:0003481)2.57923017
60Irritability (HP:0000737)2.51618969
61Turricephaly (HP:0000262)2.51317134
62Hypoglycemic seizures (HP:0002173)2.48502153
63Mitral stenosis (HP:0001718)2.47272205
64Reticulocytosis (HP:0001923)2.44969589
65Neonatal onset (HP:0003623)2.44641859
66Vascular calcification (HP:0004934)2.42530959
67Spastic diplegia (HP:0001264)2.41138125
68Hypochromic microcytic anemia (HP:0004840)2.40525516
69Acanthocytosis (HP:0001927)2.39870609
70Lethargy (HP:0001254)2.38472518
71Thin bony cortex (HP:0002753)2.37175140
72Sensorimotor neuropathy (HP:0007141)2.35322127
73Nephritis (HP:0000123)2.30649364
74Abnormal gallbladder morphology (HP:0012437)2.28876115
75Amyloidosis (HP:0011034)2.28132706
76Glomerulonephritis (HP:0000099)2.27547929
77Hyperuricemia (HP:0002149)2.26675939
78Increased purine levels (HP:0004368)2.26675939
79Esophageal varix (HP:0002040)2.26457022
80Cholelithiasis (HP:0001081)2.25091519
81Lower limb amyotrophy (HP:0007210)2.24950200
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.24291934
83Malnutrition (HP:0004395)2.23796102
84Type 1 muscle fiber predominance (HP:0003803)2.21883947
85Cholecystitis (HP:0001082)2.21839033
86Abnormal gallbladder physiology (HP:0012438)2.21839033
87Rickets (HP:0002748)2.18155892
88Dicarboxylic aciduria (HP:0003215)2.17428973
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17428973
90Axonal loss (HP:0003447)2.16964595
91Supranuclear gaze palsy (HP:0000605)2.16908355
92Status epilepticus (HP:0002133)2.15120391
93Cardiovascular calcification (HP:0011915)2.13473844
94Hypercortisolism (HP:0001578)2.12467226
95Neuronal loss in central nervous system (HP:0002529)2.11772794
96Foot dorsiflexor weakness (HP:0009027)2.11306930
97Generalized aminoaciduria (HP:0002909)2.10871962
98Abnormality of proline metabolism (HP:0010907)2.09934696
99Hydroxyprolinuria (HP:0003080)2.09934696
100Late onset (HP:0003584)2.09793374
101Muscle fiber inclusion bodies (HP:0100299)2.09308928
102Pancreatitis (HP:0001733)2.08936291
103Enlarged kidneys (HP:0000105)2.06210681
104Increased variability in muscle fiber diameter (HP:0003557)2.02996044
105Hyperacusis (HP:0010780)2.02531488
106Abnormality of nail color (HP:0100643)2.02192849
107Hemorrhage of the eye (HP:0011885)2.00676676
108Alkalosis (HP:0001948)2.00112216
109Round ear (HP:0100830)1.99652377
110Hyperglycemia (HP:0003074)1.99344731
111Broad face (HP:0000283)1.98420894
112Cerebral aneurysm (HP:0004944)1.97917438
113Recurrent gram-negative bacterial infections (HP:0005420)1.97869995
114Hyperinsulinemic hypoglycemia (HP:0000825)1.97502203
115Hypophosphatemic rickets (HP:0004912)1.96019836
116Cerebral edema (HP:0002181)1.94566912
117Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93197184
118Bulbar palsy (HP:0001283)1.92688880
119Vomiting (HP:0002013)1.92284257
120Onion bulb formation (HP:0003383)1.91705792
121Menorrhagia (HP:0000132)1.90456627
122Atrioventricular block (HP:0001678)1.90099029
123Brushfield spots (HP:0001088)1.89419468
124Pigmentary retinal degeneration (HP:0001146)1.89093518
125Abnormality of the Achilles tendon (HP:0005109)1.88738378
126Gingival bleeding (HP:0000225)1.88336381
127Upper limb amyotrophy (HP:0009129)1.86794616
128Distal upper limb amyotrophy (HP:0007149)1.86794616
129Abnormality of the foot musculature (HP:0001436)1.84877876
130Abnormality of the gallbladder (HP:0005264)1.84488685
131Thrombophlebitis (HP:0004418)1.84186465
132Poikilocytosis (HP:0004447)1.83939414
133Myokymia (HP:0002411)1.83539763
134Mildly elevated creatine phosphokinase (HP:0008180)1.82085545
135EMG: myopathic abnormalities (HP:0003458)1.81987913
136Abnormality of skeletal muscle fiber size (HP:0012084)1.79892544
137Polycythemia (HP:0001901)1.79073575
138Dysmetric saccades (HP:0000641)1.78730420
139Hyporeflexia of lower limbs (HP:0002600)1.78540668
140Insomnia (HP:0100785)1.77370754
141Death in childhood (HP:0003819)1.77336001
142Confusion (HP:0001289)1.76501739
143Hammertoe (HP:0001765)1.76199802
144Abnormal enzyme/coenzyme activity (HP:0012379)1.76159904
145Spinal rigidity (HP:0003306)1.74734963
146Abnormal cartilage morphology (HP:0002763)1.74260542
147Nemaline bodies (HP:0003798)1.74087660
148Diaphragmatic weakness (HP:0009113)1.73543903
149Ulnar claw (HP:0001178)1.72744738
150Interstitial pulmonary disease (HP:0006530)1.71725009
151Neonatal hypoglycemia (HP:0001998)1.70208760
152Distal sensory impairment (HP:0002936)1.69980179
153Hyperparathyroidism (HP:0000843)1.69452547
154Asymmetric septal hypertrophy (HP:0001670)1.68781165
155Abnormality of the fingertips (HP:0001211)1.68312764
156Stroke (HP:0001297)1.66767071
157Decreased motor nerve conduction velocity (HP:0003431)1.66143468
158Ankle clonus (HP:0011448)1.65725161
159Muscle fiber splitting (HP:0003555)1.65433222
160Annular pancreas (HP:0001734)1.63996661
161Difficulty running (HP:0009046)1.63913897
162Stridor (HP:0010307)1.63452468
163Bowel incontinence (HP:0002607)1.63196527
164Difficulty climbing stairs (HP:0003551)1.62648876
165Long palpebral fissure (HP:0000637)1.61091034
166Abnormal atrioventricular conduction (HP:0005150)1.60686501
167Rapidly progressive (HP:0003678)1.59176556
168Overgrowth (HP:0001548)1.58065694
169Ragged-red muscle fibers (HP:0003200)1.57429226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.23884262
2FGFR44.15142896
3ERN13.67551278
4SIK13.64475136
5ERBB42.76876375
6PRPF4B2.66854891
7INSRR2.63701253
8ICK2.48876888
9MAP2K42.42136660
10DAPK22.07276768
11TAOK32.02459364
12TTN1.87551410
13CDK121.81409762
14RIPK11.79769966
15PINK11.78379962
16TRIB31.74319131
17NTRK21.71176654
18IRAK31.64604817
19PIM21.60630733
20MST1R1.59472274
21EEF2K1.58192523
22MARK21.55867738
23MAP3K31.44840535
24MAP3K41.44175687
25MAPK151.42564860
26ARAF1.41154238
27PTK61.37186458
28BRAF1.34225036
29SGK31.34002611
30EPHA31.31825121
31SGK21.30925916
32MAPK111.29949783
33MAP3K21.27347501
34SMG11.25185041
35EPHB11.23433030
36ERBB21.23289537
37FRK1.22545006
38SGK4941.22137735
39SGK2231.22137735
40JAK21.21520077
41LATS11.17758860
42TAOK11.15616113
43ABL21.15504384
44PKN21.15441694
45RPS6KA21.14508347
46EPHA41.12698342
47JAK11.10999249
48TYK21.10495944
49TAOK21.09492941
50OBSCN1.08605023
51CDC42BPA1.06810861
52LATS21.04790301
53PRKAA21.02197618
54MAP3K91.02172819
55SIK21.01585945
56MAP3K71.01014898
57PRKCZ0.98659780
58STK38L0.98421725
59GSK3A0.97015971
60MAP3K140.96711311
61PDGFRA0.95203333
62STK380.94447206
63NEK90.91374988
64MAP2K30.89835523
65FGFR20.88077996
66RPS6KC10.86946407
67RPS6KL10.86946407
68IRAK20.86341372
69EPHB20.82793185
70MOS0.82332713
71PRKAA10.81055987
72MAP2K20.79364605
73PDPK10.79222143
74TBK10.76552673
75MAPK120.75855189
76RET0.75082822
77PDK40.74820012
78PDK30.74820012
79PIK3CG0.73963570
80BLK0.73905842
81KSR20.73453877
82CAMK2G0.72987811
83PTK20.71659021
84FER0.71582776
85MAPK40.71438392
86RPS6KA60.71257880
87PRKACG0.70724236
88PRKD20.70070728
89GRK60.69377373
90DMPK0.68310768
91NTRK10.67646673
92NEK60.67124649
93PAK30.66969427
94MAP2K10.66954682
95PAK60.66399355
96MAP3K10.66099618
97FGFR30.66024938
98PDK20.65867411
99TYRO30.64449261
100DYRK1B0.60798603
101WNK30.60722457
102MAP3K60.60581388
103DDR20.59686395
104MAP3K110.59213907
105RPS6KA10.56856849
106PRKCG0.55334762
107MAPK70.54993202
108RAF10.53645568
109BRD40.52934596
110UHMK10.52260292
111CAMK1D0.52046640
112PAK20.51861013
113TIE10.51661454
114MAP3K100.51196977
115GRK10.49974877
116EPHA20.49027297
117AKT30.48115078
118CAMK40.47993397
119IKBKE0.47879874
120CAMKK10.47490817
121NTRK30.47319432
122HIPK20.46694024
123PDK10.46204529
124MAP2K60.45381812
125MAPK100.45140948
126CAMK10.44830004
127KDR0.44814854
128IRAK10.44087233
129PRKCH0.44011984
130MINK10.43877507
131MTOR0.43791440
132BMX0.43769667
133SGK10.42481574
134PRKD30.42345748
135AKT20.41455745
136MAP3K130.41279547
137PHKG20.39932104
138PHKG10.39932104
139MARK10.39608425
140CDK50.38976820
141RIPK40.38706163
142STK110.35766243

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.28182073
2Nitrogen metabolism_Homo sapiens_hsa009103.78007412
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.56365994
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39480262
5Arginine biosynthesis_Homo sapiens_hsa002203.07732970
6Complement and coagulation cascades_Homo sapiens_hsa046102.54374957
7Tryptophan metabolism_Homo sapiens_hsa003802.53858623
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50789007
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49447464
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38890841
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36036476
12Fatty acid degradation_Homo sapiens_hsa000712.34982204
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.30415414
14Butanoate metabolism_Homo sapiens_hsa006502.27138796
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23278164
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.09765617
17Chemical carcinogenesis_Homo sapiens_hsa052042.08424156
18Peroxisome_Homo sapiens_hsa041461.90140781
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.88360427
20PPAR signaling pathway_Homo sapiens_hsa033201.88009176
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81307168
22Propanoate metabolism_Homo sapiens_hsa006401.77827462
23Fatty acid metabolism_Homo sapiens_hsa012121.73304954
24beta-Alanine metabolism_Homo sapiens_hsa004101.71808816
25Histidine metabolism_Homo sapiens_hsa003401.70100284
26Bile secretion_Homo sapiens_hsa049761.68759924
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.65350104
28Phenylalanine metabolism_Homo sapiens_hsa003601.59940807
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56750424
30Retinol metabolism_Homo sapiens_hsa008301.52223313
31Staphylococcus aureus infection_Homo sapiens_hsa051501.52011244
32Caffeine metabolism_Homo sapiens_hsa002321.50268288
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46812794
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46773658
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37842196
36Starch and sucrose metabolism_Homo sapiens_hsa005001.37811815
37Selenocompound metabolism_Homo sapiens_hsa004501.37304341
38Sulfur metabolism_Homo sapiens_hsa009201.32207743
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30583645
40Tyrosine metabolism_Homo sapiens_hsa003501.28991253
41Pyruvate metabolism_Homo sapiens_hsa006201.26814917
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.25162180
43Other glycan degradation_Homo sapiens_hsa005111.24009308
44ABC transporters_Homo sapiens_hsa020101.19879862
45Synaptic vesicle cycle_Homo sapiens_hsa047211.11734481
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11525652
47Biosynthesis of amino acids_Homo sapiens_hsa012301.09220936
48Fat digestion and absorption_Homo sapiens_hsa049751.09154147
49Bladder cancer_Homo sapiens_hsa052191.06051905
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.04251214
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03750707
52Notch signaling pathway_Homo sapiens_hsa043301.03553758
53Carbon metabolism_Homo sapiens_hsa012001.02606107
54Folate biosynthesis_Homo sapiens_hsa007901.00985104
55Fatty acid elongation_Homo sapiens_hsa000620.98650778
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98390659
57VEGF signaling pathway_Homo sapiens_hsa043700.96655160
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.96287637
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.94537498
60Vitamin B6 metabolism_Homo sapiens_hsa007500.90547817
61Steroid biosynthesis_Homo sapiens_hsa001000.89655931
62Vitamin digestion and absorption_Homo sapiens_hsa049770.89056703
63Arginine and proline metabolism_Homo sapiens_hsa003300.88551794
64Sulfur relay system_Homo sapiens_hsa041220.84307644
65GnRH signaling pathway_Homo sapiens_hsa049120.84164205
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82767783
67Acute myeloid leukemia_Homo sapiens_hsa052210.82296597
68Chronic myeloid leukemia_Homo sapiens_hsa052200.80733514
69ErbB signaling pathway_Homo sapiens_hsa040120.79104141
70Lysine degradation_Homo sapiens_hsa003100.78720464
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.77102471
72Vibrio cholerae infection_Homo sapiens_hsa051100.76362104
73Pertussis_Homo sapiens_hsa051330.75824203
74Glutathione metabolism_Homo sapiens_hsa004800.75424766
75Estrogen signaling pathway_Homo sapiens_hsa049150.74942001
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74403424
77Glioma_Homo sapiens_hsa052140.72735210
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72691827
79Glycerolipid metabolism_Homo sapiens_hsa005610.71951197
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71825153
81Non-small cell lung cancer_Homo sapiens_hsa052230.71501141
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71089239
83mTOR signaling pathway_Homo sapiens_hsa041500.70136517
84Renal cell carcinoma_Homo sapiens_hsa052110.66396814
85Long-term potentiation_Homo sapiens_hsa047200.66173522
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61720738
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58659669
88Fatty acid biosynthesis_Homo sapiens_hsa000610.58109908
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.55743183
90Endometrial cancer_Homo sapiens_hsa052130.52319781
91Prion diseases_Homo sapiens_hsa050200.50634101
92Hepatitis C_Homo sapiens_hsa051600.48567413
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48533679
94Amphetamine addiction_Homo sapiens_hsa050310.48228952
95Pentose phosphate pathway_Homo sapiens_hsa000300.47966570
96B cell receptor signaling pathway_Homo sapiens_hsa046620.47485070
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46924948
98TNF signaling pathway_Homo sapiens_hsa046680.46169794
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45905950
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45715467
101Insulin resistance_Homo sapiens_hsa049310.45132009
102Pancreatic secretion_Homo sapiens_hsa049720.45078831
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45054506
104MAPK signaling pathway_Homo sapiens_hsa040100.44109806
105Choline metabolism in cancer_Homo sapiens_hsa052310.43615062
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.43054219
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.42147045
108Oxytocin signaling pathway_Homo sapiens_hsa049210.42066071
109Gap junction_Homo sapiens_hsa045400.41899789
110Dilated cardiomyopathy_Homo sapiens_hsa054140.41785585
111Cholinergic synapse_Homo sapiens_hsa047250.41172596
112Galactose metabolism_Homo sapiens_hsa000520.36443757
113Metabolic pathways_Homo sapiens_hsa011000.32325929
114Fructose and mannose metabolism_Homo sapiens_hsa000510.29794553
115One carbon pool by folate_Homo sapiens_hsa006700.27398447
116Glucagon signaling pathway_Homo sapiens_hsa049220.25162689
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.23854390
118AMPK signaling pathway_Homo sapiens_hsa041520.15275659
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11759734
120Type II diabetes mellitus_Homo sapiens_hsa049300.10567374
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09153401
122Insulin signaling pathway_Homo sapiens_hsa049100.06993434
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04567683
124Circadian rhythm_Homo sapiens_hsa047100.02259941
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00670990
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.00632326
127Cocaine addiction_Homo sapiens_hsa05030-0.1487474
128FoxO signaling pathway_Homo sapiens_hsa04068-0.1475439
129Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1468039
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1466728
131Prolactin signaling pathway_Homo sapiens_hsa04917-0.1424788
132Amoebiasis_Homo sapiens_hsa05146-0.1387918
133Mineral absorption_Homo sapiens_hsa04978-0.1262902
134Regulation of autophagy_Homo sapiens_hsa04140-0.1225548
135GABAergic synapse_Homo sapiens_hsa04727-0.0823715
136Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0562594
137African trypanosomiasis_Homo sapiens_hsa05143-0.0560883
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0456949
139Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0432313
140Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0299890
141Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0118361
142Linoleic acid metabolism_Homo sapiens_hsa00591-0.0073300

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