SLC25A17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is expressed in the liver, and is likely involved in transport. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein deneddylation (GO:0000338)4.70784467
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.59138437
3cullin deneddylation (GO:0010388)4.59040129
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.36450736
5DNA replication checkpoint (GO:0000076)4.11575213
6aldehyde catabolic process (GO:0046185)4.11348494
7proteasome assembly (GO:0043248)4.00256601
8signal peptide processing (GO:0006465)4.00087426
9DNA strand elongation involved in DNA replication (GO:0006271)3.98284157
10regulation of mitochondrial translation (GO:0070129)3.92911694
11protein localization to kinetochore (GO:0034501)3.89560681
12COPI coating of Golgi vesicle (GO:0048205)3.85518140
13Golgi transport vesicle coating (GO:0048200)3.85518140
14CENP-A containing nucleosome assembly (GO:0034080)3.82511737
15DNA strand elongation (GO:0022616)3.81903718
16chromatin remodeling at centromere (GO:0031055)3.80255858
17ATP synthesis coupled proton transport (GO:0015986)3.76725220
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76725220
19ribosome assembly (GO:0042255)3.72922983
20mitotic metaphase plate congression (GO:0007080)3.67490783
21telomere maintenance via semi-conservative replication (GO:0032201)3.60166272
22establishment of integrated proviral latency (GO:0075713)3.58113517
23protein K6-linked ubiquitination (GO:0085020)3.55704162
24respiratory chain complex IV assembly (GO:0008535)3.55457578
25pseudouridine synthesis (GO:0001522)3.52853206
26folic acid-containing compound biosynthetic process (GO:0009396)3.50885969
27termination of RNA polymerase III transcription (GO:0006386)3.46865028
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46405874
29maturation of 5.8S rRNA (GO:0000460)3.42255993
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41996888
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.41474405
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.41474405
33regulation of cellular amino acid metabolic process (GO:0006521)3.40127787
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39726061
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39726061
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39726061
37IMP biosynthetic process (GO:0006188)3.37952875
38protein localization to chromosome, centromeric region (GO:0071459)3.35838410
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.35646674
40regulation of ubiquitin-protein transferase activity (GO:0051438)3.30563666
41mitochondrial respiratory chain complex assembly (GO:0033108)3.29430655
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.28858524
43metaphase plate congression (GO:0051310)3.28460911
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.25308192
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25017861
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24539185
47protein targeting to mitochondrion (GO:0006626)3.23514260
48spliceosomal snRNP assembly (GO:0000387)3.22318737
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.21938700
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21938700
51regulation of ligase activity (GO:0051340)3.19577489
52protein complex biogenesis (GO:0070271)3.19419680
53histone exchange (GO:0043486)3.18631469
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17734877
55spindle checkpoint (GO:0031577)3.16829067
56DNA damage response, detection of DNA damage (GO:0042769)3.16140601
57amino acid activation (GO:0043038)3.16038936
58tRNA aminoacylation (GO:0043039)3.16038936
59rRNA processing (GO:0006364)3.15965531
60DNA catabolic process, exonucleolytic (GO:0000738)3.15623157
61mitotic sister chromatid segregation (GO:0000070)3.14976066
62branched-chain amino acid catabolic process (GO:0009083)3.14511856
63antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.14356379
64protein neddylation (GO:0045116)3.14285620
65tRNA aminoacylation for protein translation (GO:0006418)3.13132971
66cytochrome complex assembly (GO:0017004)3.13019450
67pteridine-containing compound biosynthetic process (GO:0042559)3.12590525
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11832578
69negative regulation of ligase activity (GO:0051352)3.10935057
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10935057
71purine nucleobase biosynthetic process (GO:0009113)3.10843085
72mitochondrial RNA metabolic process (GO:0000959)3.09918370
73respiratory electron transport chain (GO:0022904)3.09024816
74L-phenylalanine catabolic process (GO:0006559)3.08244616
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08244616
76mitotic spindle checkpoint (GO:0071174)3.07450106
77regulation of mitotic spindle checkpoint (GO:1903504)3.06939350
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06939350
79ribosome biogenesis (GO:0042254)3.06828857
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05978968
81antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.05849042
82L-serine metabolic process (GO:0006563)3.05629114
83ribosomal large subunit biogenesis (GO:0042273)3.05259322
84amino acid salvage (GO:0043102)3.04571748
85L-methionine salvage (GO:0071267)3.04571748
86L-methionine biosynthetic process (GO:0071265)3.04571748
87oxidative phosphorylation (GO:0006119)3.04120616
88telomere maintenance via recombination (GO:0000722)3.04064192
89electron transport chain (GO:0022900)3.03073300
90inner mitochondrial membrane organization (GO:0007007)3.02742872
91tryptophan catabolic process (GO:0006569)3.02662482
92indole-containing compound catabolic process (GO:0042436)3.02662482
93indolalkylamine catabolic process (GO:0046218)3.02662482
94rRNA metabolic process (GO:0016072)3.02658216
95serine family amino acid biosynthetic process (GO:0009070)3.01708746
96aromatic amino acid family catabolic process (GO:0009074)3.00067430
97viral protein processing (GO:0019082)2.99576043
98protein localization to mitochondrion (GO:0070585)2.98161830
99L-phenylalanine metabolic process (GO:0006558)2.97981484
100erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97981484
101establishment of protein localization to mitochondrion (GO:0072655)2.97661442
102negative regulation of chromosome segregation (GO:0051985)2.97413054
103rRNA modification (GO:0000154)2.97373838
104cellular ketone body metabolic process (GO:0046950)2.96482318
105mitotic recombination (GO:0006312)2.96471448
106cholesterol biosynthetic process (GO:0006695)2.96121499
107water-soluble vitamin biosynthetic process (GO:0042364)2.95696079
108tryptophan metabolic process (GO:0006568)2.95593247
109cell cycle G1/S phase transition (GO:0044843)2.95279883
110G1/S transition of mitotic cell cycle (GO:0000082)2.95279883
111kinetochore organization (GO:0051383)2.95149073
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95135762
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95135762
114negative regulation of sister chromatid segregation (GO:0033046)2.95135762
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94089580
116glyoxylate metabolic process (GO:0046487)2.93731396
117xenobiotic catabolic process (GO:0042178)2.85809855
118ribosomal small subunit assembly (GO:0000028)2.83916687
119DNA deamination (GO:0045006)2.83453961
120rRNA methylation (GO:0031167)2.82595090
121nucleobase biosynthetic process (GO:0046112)2.81756410
122chaperone-mediated protein transport (GO:0072321)2.81641265
123fat-soluble vitamin biosynthetic process (GO:0042362)2.81075630
124branched-chain amino acid metabolic process (GO:0009081)2.77056022
125valine metabolic process (GO:0006573)2.75198541
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74327074
127formation of translation preinitiation complex (GO:0001731)2.73120789
128peptide catabolic process (GO:0043171)2.71675347
129viral mRNA export from host cell nucleus (GO:0046784)2.70029580
130misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.67588879
131peptidyl-histidine modification (GO:0018202)2.66547578
132sulfur amino acid catabolic process (GO:0000098)2.66366870
133positive regulation of ligase activity (GO:0051351)2.64998504
134positive regulation of cell cycle arrest (GO:0071158)2.60155815
135cysteine metabolic process (GO:0006534)2.59789945
136nucleotide-sugar biosynthetic process (GO:0009226)2.59227809
137response to misfolded protein (GO:0051788)2.57688922
138regulation of cellular amine metabolic process (GO:0033238)2.56452886
139uronic acid metabolic process (GO:0006063)2.56353696
140glucuronate metabolic process (GO:0019585)2.56353696
141DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.55756269
142folic acid transport (GO:0015884)2.54377598
143de novo posttranslational protein folding (GO:0051084)2.54079788
144sterol biosynthetic process (GO:0016126)2.51847649
1457-methylguanosine mRNA capping (GO:0006370)2.51503433
146sulfur amino acid biosynthetic process (GO:0000097)2.49871740
147RNA capping (GO:0036260)2.49628196
1487-methylguanosine RNA capping (GO:0009452)2.49628196
149mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49400262
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.49400262
151NADH dehydrogenase complex assembly (GO:0010257)2.49400262
152urate metabolic process (GO:0046415)2.48082126
153regulation of metalloenzyme activity (GO:0048552)2.47151457
154ketone body metabolic process (GO:1902224)2.46876333
155amine catabolic process (GO:0009310)2.46613115
156cellular biogenic amine catabolic process (GO:0042402)2.46613115
157de novo protein folding (GO:0006458)2.45316820
158response to nitrosative stress (GO:0051409)2.44275734
159removal of superoxide radicals (GO:0019430)2.40861702
160cellular response to superoxide (GO:0071451)2.40861702
161cellular response to oxygen radical (GO:0071450)2.40861702
162imidazole-containing compound metabolic process (GO:0052803)2.38792520
163bile acid biosynthetic process (GO:0006699)2.38253803
164kynurenine metabolic process (GO:0070189)2.38155101
165positive regulation of actin filament depolymerization (GO:0030836)2.37891407
166DNA double-strand break processing (GO:0000729)2.36002046
167methionine biosynthetic process (GO:0009086)2.35282267
168transcription elongation from RNA polymerase III promoter (GO:0006385)2.34822787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67248227
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.86924673
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36630842
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.36187006
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.12058005
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.98431002
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.97497128
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.95161590
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93927151
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.86349810
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84779078
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83587734
13E2F7_22180533_ChIP-Seq_HELA_Human2.74227887
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.69806667
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.66024056
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59547241
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59050156
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56029160
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.49339666
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.48896968
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47093789
22ELK1_19687146_ChIP-ChIP_HELA_Human2.46956852
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.44834904
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36822907
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35644815
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34115776
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28397366
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27333379
29DCP1A_22483619_ChIP-Seq_HELA_Human2.22916846
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08250619
31* VDR_23849224_ChIP-Seq_CD4+_Human2.08048357
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03604182
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95805980
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95546274
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93392816
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87797115
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85679131
38AR_21909140_ChIP-Seq_LNCAP_Human1.75448700
39FOXP3_21729870_ChIP-Seq_TREG_Human1.73870566
40GABP_19822575_ChIP-Seq_HepG2_Human1.72879165
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.72478850
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68709527
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61801198
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58030229
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56602750
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56592542
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56301157
48XRN2_22483619_ChIP-Seq_HELA_Human1.55291428
49MYC_18940864_ChIP-ChIP_HL60_Human1.52664536
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50186388
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48910056
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.48262589
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47843050
54* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47237630
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.42219648
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39751345
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38983211
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38817937
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38146612
60* SOX17_20123909_ChIP-Seq_XEN_Mouse1.34485071
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33444523
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32696684
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32111806
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32051820
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.30502934
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30073397
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.26477853
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.24995736
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.24862384
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23861381
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22423947
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.21291800
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19642710
74TTF2_22483619_ChIP-Seq_HELA_Human1.18504605
75TFEB_21752829_ChIP-Seq_HELA_Human1.15199161
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14686643
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13546695
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13437179
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12836416
80* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12764832
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12333440
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10729291
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.07287741
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06787963
85* CLOCK_20551151_ChIP-Seq_293T_Human1.06004026
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05631202
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05286689
88IRF1_19129219_ChIP-ChIP_H3396_Human1.03983723
89FUS_26573619_Chip-Seq_HEK293_Human1.03283464
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02485124
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.02042019
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.01580117
93GATA1_22025678_ChIP-Seq_K562_Human1.01439920
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00042706
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99712394
96KDM5A_27292631_Chip-Seq_BREAST_Human0.99031466
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97880065
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96501377
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94335084
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.94184014
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93896260
102TRIM28_21343339_ChIP-Seq_HEK293_Human0.89995618
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89301103
104ZNF274_21170338_ChIP-Seq_K562_Hela0.88489623
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.87849973
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87440928
107VDR_22108803_ChIP-Seq_LS180_Human0.86745657
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85952022
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85127881
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84892582
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84521003
112NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83919596
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83131227
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81578080
115* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80813657
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78875710
117EWS_26573619_Chip-Seq_HEK293_Human0.78692565
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74700436
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72862875
120CIITA_25753668_ChIP-Seq_RAJI_Human0.72797463
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71981429
122ELF5_23300383_ChIP-Seq_T47D_Human0.69844459
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68992747
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67818124
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67766806
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66623898
127POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66218293
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.65869244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.73685569
2MP0003111_abnormal_nucleus_morphology3.89133844
3MP0002139_abnormal_hepatobiliary_system3.80958971
4MP0003186_abnormal_redox_activity2.94542626
5MP0005360_urolithiasis2.91728710
6MP0005365_abnormal_bile_salt2.89512649
7MP0005085_abnormal_gallbladder_physiolo2.78199307
8MP0008875_abnormal_xenobiotic_pharmacok2.77823708
9MP0003195_calcinosis2.57986647
10MP0009697_abnormal_copulation2.46057603
11MP0001529_abnormal_vocalization2.35748342
12MP0006035_abnormal_mitochondrial_morpho2.35033871
13MP0008007_abnormal_cellular_replicative2.14073095
14MP0008877_abnormal_DNA_methylation2.10412277
15MP0006054_spinal_hemorrhage2.05017807
16MP0002138_abnormal_hepatobiliary_system2.00095691
17MP0005332_abnormal_amino_acid1.95500384
18MP0002102_abnormal_ear_morphology1.92236702
19MP0005408_hypopigmentation1.90506727
20MP0001764_abnormal_homeostasis1.89243300
21MP0005084_abnormal_gallbladder_morpholo1.86514823
22MP0004782_abnormal_surfactant_physiolog1.84108886
23MP0004019_abnormal_vitamin_homeostasis1.81747011
24MP0003693_abnormal_embryo_hatching1.81609310
25MP0000566_synostosis1.76009737
26MP0003718_maternal_effect1.75289802
27MP0004957_abnormal_blastocyst_morpholog1.64116808
28MP0002132_abnormal_respiratory_system1.56386176
29MP0002876_abnormal_thyroid_physiology1.56349721
30MP0001730_embryonic_growth_arrest1.56019063
31MP0000350_abnormal_cell_proliferation1.54835059
32MP0008058_abnormal_DNA_repair1.52864680
33MP0000358_abnormal_cell_content/1.51901141
34MP0003724_increased_susceptibility_to1.49932175
35MP0009643_abnormal_urine_homeostasis1.49388534
36MP0003941_abnormal_skin_development1.43357253
37MP0003136_yellow_coat_color1.40354600
38MP0002160_abnormal_reproductive_system1.40326355
39MP0008438_abnormal_cutaneous_collagen1.36220497
40MP0005220_abnormal_exocrine_pancreas1.36112334
41MP0005645_abnormal_hypothalamus_physiol1.33316176
42MP0001697_abnormal_embryo_size1.33120437
43MP0010307_abnormal_tumor_latency1.32425185
44MP0006072_abnormal_retinal_apoptosis1.32389602
45MP0005636_abnormal_mineral_homeostasis1.29350176
46MP0003252_abnormal_bile_duct1.28890812
47MP0002163_abnormal_gland_morphology1.28820425
48MP0009384_cardiac_valve_regurgitation1.27695956
49MP0001666_abnormal_nutrient_absorption1.27536453
50MP0005380_embryogenesis_phenotype1.26813708
51MP0001672_abnormal_embryogenesis/_devel1.26813708
52MP0009785_altered_susceptibility_to1.25370054
53MP0008995_early_reproductive_senescence1.25228621
54MP0005075_abnormal_melanosome_morpholog1.24969876
55MP0003077_abnormal_cell_cycle1.24569453
56MP0001542_abnormal_bone_strength1.24065413
57MP0009053_abnormal_anal_canal1.22846499
58MP0002090_abnormal_vision1.22261901
59MP0003786_premature_aging1.21945781
60MP0008932_abnormal_embryonic_tissue1.20694962
61MP0000647_abnormal_sebaceous_gland1.20670876
62MP0010094_abnormal_chromosome_stability1.20528836
63MP0003943_abnormal_hepatobiliary_system1.20255879
64MP0005083_abnormal_biliary_tract1.20156636
65MP0006292_abnormal_olfactory_placode1.17825568
66MP0002938_white_spotting1.17367076
67MP0010329_abnormal_lipoprotein_level1.13151347
68MP0010030_abnormal_orbit_morphology1.12490096
69MP0004043_abnormal_pH_regulation1.12478512
70MP0002084_abnormal_developmental_patter1.12131897
71MP0002877_abnormal_melanocyte_morpholog1.12026656
72MP0002080_prenatal_lethality1.10135468
73MP0002234_abnormal_pharynx_morphology1.08952218
74MP0008789_abnormal_olfactory_epithelium1.08662407
75MP0002085_abnormal_embryonic_tissue1.08637171
76MP0001984_abnormal_olfaction1.07296798
77MP0002210_abnormal_sex_determination1.06132892
78MP0000313_abnormal_cell_death1.05535808
79MP0001929_abnormal_gametogenesis1.04800131
80MP0003937_abnormal_limbs/digits/tail_de1.04665725
81MP0003984_embryonic_growth_retardation1.03578526
82MP0010352_gastrointestinal_tract_polyps1.02836855
83MP0003567_abnormal_fetal_cardiomyocyte1.01916427
84MP0001756_abnormal_urination0.99616718
85MP0005379_endocrine/exocrine_gland_phen0.98740215
86MP0002088_abnormal_embryonic_growth/wei0.97682784
87MP0005187_abnormal_penis_morphology0.97664233
88MP0005319_abnormal_enzyme/_coenzyme0.95556020
89MP0002282_abnormal_trachea_morphology0.95474871
90MP0008057_abnormal_DNA_replication0.95281616
91MP0005394_taste/olfaction_phenotype0.94993110
92MP0005499_abnormal_olfactory_system0.94993110
93MP0005503_abnormal_tendon_morphology0.94594945
94MP0009672_abnormal_birth_weight0.93885124
95MP0001243_abnormal_dermal_layer0.93637674
96MP0001661_extended_life_span0.92967448
97MP0006036_abnormal_mitochondrial_physio0.92719293
98MP0002751_abnormal_autonomic_nervous0.91823706
99MP0001145_abnormal_male_reproductive0.90788298
100MP0001188_hyperpigmentation0.89778567
101MP0009333_abnormal_splenocyte_physiolog0.89218705
102MP0005395_other_phenotype0.88306201
103MP0009250_abnormal_appendicular_skeleto0.88009200
104MP0000653_abnormal_sex_gland0.87369625
105MP0002254_reproductive_system_inflammat0.86258754
106MP0002396_abnormal_hematopoietic_system0.85661501
107MP0002148_abnormal_hypersensitivity_rea0.84997019
108MP0005389_reproductive_system_phenotype0.84876922
109MP0002060_abnormal_skin_morphology0.83899532
110MP0005253_abnormal_eye_physiology0.82967136
111MP0002136_abnormal_kidney_physiology0.81717724
112MP0003950_abnormal_plasma_membrane0.81588712
113MP0003942_abnormal_urinary_system0.81218955
114MP0001958_emphysema0.81196300
115MP0001293_anophthalmia0.81083736
116MP0000598_abnormal_liver_morphology0.80834543
117MP0004264_abnormal_extraembryonic_tissu0.80218285
118MP0009764_decreased_sensitivity_to0.80208390
119MP0004147_increased_porphyrin_level0.80101562
120MP0003890_abnormal_embryonic-extraembry0.79963980
121MP0003315_abnormal_perineum_morphology0.77444633
122MP0000538_abnormal_urinary_bladder0.76693348
123MP0002098_abnormal_vibrissa_morphology0.76549302
124MP0002006_tumorigenesis0.75706763
125MP0000678_abnormal_parathyroid_gland0.74998275
126MP0005508_abnormal_skeleton_morphology0.74884975
127MP0008469_abnormal_protein_level0.74715819
128MP0004133_heterotaxia0.74407719
129MP0000609_abnormal_liver_physiology0.74044809
130MP0002933_joint_inflammation0.73599939
131MP0000372_irregular_coat_pigmentation0.73039760
132MP0005584_abnormal_enzyme/coenzyme_acti0.72786296
133MP0001177_atelectasis0.72539849
134MP0000613_abnormal_salivary_gland0.71735993
135MP0005275_abnormal_skin_tensile0.71658550
136MP0005376_homeostasis/metabolism_phenot0.70685875
137MP0008260_abnormal_autophagy0.70627112
138MP0002009_preneoplasia0.70431895
139MP0001119_abnormal_female_reproductive0.69846422
140MP0003119_abnormal_digestive_system0.69745826
141MP0001905_abnormal_dopamine_level0.68891379
142MP0001286_abnormal_eye_development0.68428262
143MP0001346_abnormal_lacrimal_gland0.68100991
144MP0002019_abnormal_tumor_incidence0.67725124
145MP0002095_abnormal_skin_pigmentation0.67669702
146MP0001727_abnormal_embryo_implantation0.67406988
147MP0003656_abnormal_erythrocyte_physiolo0.67209446
148MP0005390_skeleton_phenotype0.66818987
149MP0001881_abnormal_mammary_gland0.66220891
150MP0004134_abnormal_chest_morphology0.66218174
151MP0000427_abnormal_hair_cycle0.66090253
152MP0002233_abnormal_nose_morphology0.66066996
153MP0004197_abnormal_fetal_growth/weight/0.65933259
154MP0002118_abnormal_lipid_homeostasis0.65661770
155MP0002697_abnormal_eye_size0.65572711
156MP0003698_abnormal_male_reproductive0.64844950
157MP0002111_abnormal_tail_morphology0.64379243
158MP0000163_abnormal_cartilage_morphology0.64335774
159MP0002736_abnormal_nociception_after0.64207069
160MP0009765_abnormal_xenobiotic_induced0.63975298
161MP0005501_abnormal_skin_physiology0.63959795
162MP0000631_abnormal_neuroendocrine_gland0.62917712
163MP0002295_abnormal_pulmonary_circulatio0.62344385
164MP0002909_abnormal_adrenal_gland0.61699655
165MP0000858_altered_metastatic_potential0.59267044
166MP0002086_abnormal_extraembryonic_tissu0.59217096
167MP0002277_abnormal_respiratory_mucosa0.58797706
168MP0010234_abnormal_vibrissa_follicle0.58484923
169MP0001915_intracranial_hemorrhage0.57954962
170MP0003755_abnormal_palate_morphology0.56782072
171MP0004215_abnormal_myocardial_fiber0.56759546

Predicted human phenotypes

RankGene SetZ-score
1Progressive macrocephaly (HP:0004481)3.77638204
2Abnormality of fatty-acid metabolism (HP:0004359)3.70072752
3Increased hepatocellular lipid droplets (HP:0006565)3.64910695
4Generalized aminoaciduria (HP:0002909)3.47112908
5Increased serum pyruvate (HP:0003542)3.33503724
6Abnormality of glycolysis (HP:0004366)3.33503724
7Microvesicular hepatic steatosis (HP:0001414)3.32370279
8Lipid accumulation in hepatocytes (HP:0006561)3.28892985
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06749213
10Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.03452303
11Renal Fanconi syndrome (HP:0001994)3.00841465
12Hypobetalipoproteinemia (HP:0003563)2.91809407
13Hepatic necrosis (HP:0002605)2.88589542
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78812320
15Chromsome breakage (HP:0040012)2.76389165
16Abnormality of the labia minora (HP:0012880)2.74854613
17Colon cancer (HP:0003003)2.73593261
18Proximal tubulopathy (HP:0000114)2.67158431
19Intrahepatic cholestasis (HP:0001406)2.64885175
20Lactic acidosis (HP:0003128)2.63627170
21Irregular epiphyses (HP:0010582)2.63603405
22Opisthotonus (HP:0002179)2.59376107
233-Methylglutaconic aciduria (HP:0003535)2.58192100
24Meckel diverticulum (HP:0002245)2.52507155
25Type I transferrin isoform profile (HP:0003642)2.48215040
26Respiratory failure (HP:0002878)2.47776416
27Hepatocellular necrosis (HP:0001404)2.47776242
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47509815
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47509815
30Methylmalonic acidemia (HP:0002912)2.46794130
31Abnormality of the preputium (HP:0100587)2.45140871
32Hyperglycinuria (HP:0003108)2.40922431
33Conjugated hyperbilirubinemia (HP:0002908)2.40162818
34Abnormality of glycine metabolism (HP:0010895)2.39452084
35Abnormality of serine family amino acid metabolism (HP:0010894)2.39452084
36Abnormality of the ileum (HP:0001549)2.39234809
37Gout (HP:0001997)2.38849754
38Abnormality of chromosome stability (HP:0003220)2.38123416
39Hypoglycemic coma (HP:0001325)2.37777224
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35051918
41Pancreatic islet-cell hyperplasia (HP:0004510)2.33731523
42Delayed epiphyseal ossification (HP:0002663)2.29760285
43Renal cortical cysts (HP:0000803)2.28813222
44Hypoplasia of the uterus (HP:0000013)2.28678292
45Exercise intolerance (HP:0003546)2.27610343
46Leukodystrophy (HP:0002415)2.27417349
47Epiphyseal stippling (HP:0010655)2.26648242
48Ependymoma (HP:0002888)2.24590465
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.24580761
50Reticulocytopenia (HP:0001896)2.24249624
51Steatorrhea (HP:0002570)2.22698043
52Hyperglycinemia (HP:0002154)2.22047261
53Fat malabsorption (HP:0002630)2.21667345
54Abnormality of the intrinsic pathway (HP:0010989)2.21359821
55Hyperinsulinemic hypoglycemia (HP:0000825)2.20866556
56Dicarboxylic aciduria (HP:0003215)2.20132571
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20132571
58Brushfield spots (HP:0001088)2.20025904
59Abnormal epiphyseal ossification (HP:0010656)2.19563195
60Sparse eyelashes (HP:0000653)2.19100234
61Abnormality of urine glucose concentration (HP:0011016)2.18473518
62Glycosuria (HP:0003076)2.18473518
63Hyperammonemia (HP:0001987)2.17880456
64Enlarged kidneys (HP:0000105)2.17221115
65Acute encephalopathy (HP:0006846)2.14046895
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13991317
67Degeneration of anterior horn cells (HP:0002398)2.13731220
68Abnormality of the anterior horn cell (HP:0006802)2.13731220
69Abnormality of homocysteine metabolism (HP:0010919)2.13598518
70Homocystinuria (HP:0002156)2.13598518
71Oral leukoplakia (HP:0002745)2.11352835
72Abnormality of serum amino acid levels (HP:0003112)2.11275234
73Hypothermia (HP:0002045)2.11256819
74Increased CSF lactate (HP:0002490)2.10588627
75Multiple enchondromatosis (HP:0005701)2.08835528
76Respiratory difficulties (HP:0002880)2.06736757
77Lethargy (HP:0001254)2.06316413
78Microretrognathia (HP:0000308)2.06182681
79Cerebral hypomyelination (HP:0006808)2.06064361
80Duodenal stenosis (HP:0100867)2.05340401
81Small intestinal stenosis (HP:0012848)2.05340401
82Acute necrotizing encephalopathy (HP:0006965)2.04367273
83Megaloblastic anemia (HP:0001889)2.03603728
84Beaking of vertebral bodies (HP:0004568)2.02912191
85Abnormal number of erythroid precursors (HP:0012131)2.02796473
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02166954
87Abnormal protein glycosylation (HP:0012346)2.02083686
88Abnormal glycosylation (HP:0012345)2.02083686
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02083686
90Abnormal protein N-linked glycosylation (HP:0012347)2.02083686
91Poor head control (HP:0002421)2.01190335
92Abnormal mitochondria in muscle tissue (HP:0008316)2.00136913
93Increased serum lactate (HP:0002151)1.99152840
94Prolonged partial thromboplastin time (HP:0003645)1.96769816
95Macrocytic anemia (HP:0001972)1.96408425
96Increased intramyocellular lipid droplets (HP:0012240)1.96337086
97Abnormality of methionine metabolism (HP:0010901)1.96307760
98Mitochondrial inheritance (HP:0001427)1.96139916
99Exertional dyspnea (HP:0002875)1.92344227
100Aplasia/hypoplasia of the uterus (HP:0008684)1.92086099
101Rough bone trabeculation (HP:0100670)1.91217911
102Vertebral compression fractures (HP:0002953)1.90734521
103Optic disc pallor (HP:0000543)1.90677171
104Nausea (HP:0002018)1.90241583
105Pancytopenia (HP:0001876)1.89332634
106Prolonged neonatal jaundice (HP:0006579)1.89190319
107Reduced antithrombin III activity (HP:0001976)1.89071146
108Onycholysis (HP:0001806)1.89054211
109Respiratory distress (HP:0002098)1.88369246
110Cerebral edema (HP:0002181)1.87768760
111Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87355720
112Abnormal cartilage morphology (HP:0002763)1.86711591
113Hyperbilirubinemia (HP:0002904)1.86518898
114Abnormality of purine metabolism (HP:0004352)1.86234948
115Birth length less than 3rd percentile (HP:0003561)1.85171107
116Abnormality of alanine metabolism (HP:0010916)1.84986047
117Hyperalaninemia (HP:0003348)1.84986047
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84986047
119CNS demyelination (HP:0007305)1.84334014
120Symptomatic seizures (HP:0011145)1.84085240
121Hypoglycemic seizures (HP:0002173)1.83818439
122Abnormality of the duodenum (HP:0002246)1.83062148
123Abnormality of cells of the erythroid lineage (HP:0012130)1.82848428
124Horseshoe kidney (HP:0000085)1.82484618
125Aplastic anemia (HP:0001915)1.82301343
126Abnormality of nucleobase metabolism (HP:0010932)1.81898871
127Abnormal pancreas size (HP:0012094)1.80720939
128Glioma (HP:0009733)1.80260178
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.80038161
130Epiphyseal dysplasia (HP:0002656)1.79442005
131Methylmalonic aciduria (HP:0012120)1.79281940
132Sloping forehead (HP:0000340)1.78793800
133Abnormality of renal resorption (HP:0011038)1.78181376
134Ketoacidosis (HP:0001993)1.77442430
135Congenital, generalized hypertrichosis (HP:0004540)1.76496413
136Nonimmune hydrops fetalis (HP:0001790)1.76214594
137Abnormal tarsal ossification (HP:0008369)1.75208495
138Abnormality of the pons (HP:0007361)1.74717142
139Abnormal trabecular bone morphology (HP:0100671)1.74300507
140Vacuolated lymphocytes (HP:0001922)1.74217633
141Selective tooth agenesis (HP:0001592)1.73369183
142Abnormality of pyrimidine metabolism (HP:0004353)1.73226717
143Postnatal microcephaly (HP:0005484)1.72453938
144Metaphyseal irregularity (HP:0003025)1.72020106
145Redundant skin (HP:0001582)1.71840226
146Neoplasm of the colon (HP:0100273)1.70745679
147X-linked dominant inheritance (HP:0001423)1.70732121
148Neoplasm of the adrenal gland (HP:0100631)1.69352317
149Delayed myelination (HP:0012448)1.69121171
150Delayed CNS myelination (HP:0002188)1.68649598
151Dry hair (HP:0011359)1.68096511
152Myelodysplasia (HP:0002863)1.65975193
153Abnormal lung lobation (HP:0002101)1.64147451
154True hermaphroditism (HP:0010459)1.63945902
155Xanthomatosis (HP:0000991)1.63731228
156Pancreatic cysts (HP:0001737)1.63544449
157Metabolic acidosis (HP:0001942)1.63356343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB33.65786180
2TIE13.55656344
3VRK23.25194351
4EIF2AK13.01931925
5TTK2.87818700
6BUB12.73290449
7TSSK62.51050115
8EIF2AK32.48257856
9BCKDK2.36677012
10INSRR2.33243860
11TRIM282.10660965
12BCR2.07132959
13BMPR21.98008466
14PLK41.97719551
15TESK11.94534335
16LIMK11.93436452
17MKNK21.92629073
18MAP3K121.82927832
19STK161.82848219
20MAP3K141.80458071
21PASK1.76024133
22MST41.70341955
23NEK91.67980394
24NME11.67271089
25ZAK1.56002039
26BRSK21.55223186
27PIM21.52307320
28NUAK11.50469320
29STK38L1.48269914
30CDK81.42795503
31TEC1.37866731
32WNK31.37218764
33VRK11.37094783
34SIK31.36979799
35MAP3K31.35548890
36SRPK11.33663478
37EPHA21.33376629
38IRAK31.31748925
39PBK1.27478921
40CCNB11.26347228
41PLK31.26100138
42MKNK11.25647903
43BMPR1B1.22839351
44NME21.20260481
45AKT31.18932666
46OXSR11.17966794
47CHEK21.14141759
48TGFBR11.10043528
49EIF2AK21.06758419
50ALK1.06251317
51TLK11.05911462
52TAF11.05872422
53TESK21.04232871
54MAP4K21.03776049
55ERBB41.02145073
56CSNK1G11.01717669
57PIK3CG1.01626670
58DYRK21.01367554
59TXK1.00138685
60CSNK1A1L0.97639442
61CSNK1G20.96988550
62MYLK0.96565235
63RPS6KB20.94486852
64DAPK10.89405139
65TRPM70.88895618
66IRAK40.82164803
67YES10.81485990
68TNIK0.81272553
69WNK40.78740582
70BLK0.78653259
71BRSK10.76658477
72ATM0.75355637
73STK40.74979809
74BRAF0.74220431
75ACVR1B0.72590427
76PLK20.72372893
77WEE10.70621561
78CHEK10.69298532
79NEK10.68934238
80GRK10.68352137
81KDR0.68235694
82EPHA30.66959986
83AURKA0.65527557
84CDK70.64931443
85AURKB0.64368364
86PLK10.61944937
87MAPKAPK50.61418173
88LATS10.60594753
89MAPKAPK30.59064544
90IRAK10.58820716
91PNCK0.57940366
92ATR0.56541243
93CSNK2A10.54456958
94CASK0.54130679
95LRRK20.54097954
96CSNK2A20.53367223
97STK100.52982176
98NEK60.51963178
99NEK20.50976433
100FGFR40.50969885
101SGK20.50748729
102ABL20.50174565
103ADRBK20.48598771
104RPS6KA40.48597287
105PRKCD0.48446896
106RPS6KA50.48214646
107PRKCI0.47424323
108STK390.46054097
109ZAP700.45448376
110IRAK20.44733630
111ADRBK10.44294744
112CSNK1E0.42814230
113DDR20.42056410
114PDK20.41467354
115CHUK0.40963281
116SCYL20.40539067
117ILK0.40467312
118PAK40.39874859
119IKBKB0.39429194
120RPS6KB10.39110097
121STK30.38663238
122CDK30.38477562
123FLT30.38436970
124CDK10.37626512
125CLK10.37009779
126CSNK1G30.36681304
127STK240.33631247
128IGF1R0.33357825
129CDK20.32975883
130MAPKAPK20.32932515
131DYRK30.32785561
132CDC70.32774795
133MOS0.31617097
134SGK2230.31374506
135MAP2K70.31143491
136PRKDC0.30374758
137AKT20.28900956
138PRKCG0.28200391
139MAP3K80.27998470
140MELK0.25380005
141NLK0.24387634
142DAPK30.23484632

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.45743758
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78231833
3Protein export_Homo sapiens_hsa030602.67550098
4Sulfur metabolism_Homo sapiens_hsa009202.13315512
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01168221
6Steroid biosynthesis_Homo sapiens_hsa001001.94319494
7Fanconi anemia pathway_Homo sapiens_hsa034601.81763180
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79065591
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.75695788
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75276968
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74967091
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74491964
13* Peroxisome_Homo sapiens_hsa041461.72859710
14Drug metabolism - other enzymes_Homo sapiens_hsa009831.72189331
15RNA polymerase_Homo sapiens_hsa030201.69376612
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68703492
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66771926
18Fatty acid elongation_Homo sapiens_hsa000621.66248085
19Folate biosynthesis_Homo sapiens_hsa007901.65481072
20Butanoate metabolism_Homo sapiens_hsa006501.64565566
21Glutathione metabolism_Homo sapiens_hsa004801.64517224
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63523294
23DNA replication_Homo sapiens_hsa030301.62472093
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62184636
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56334935
26Chemical carcinogenesis_Homo sapiens_hsa052041.53613729
27Propanoate metabolism_Homo sapiens_hsa006401.52729613
28Alzheimers disease_Homo sapiens_hsa050101.49516392
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46363225
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45304155
31One carbon pool by folate_Homo sapiens_hsa006701.44947639
32Tryptophan metabolism_Homo sapiens_hsa003801.42226671
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40930407
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35587709
35Pyrimidine metabolism_Homo sapiens_hsa002401.35560162
36Selenocompound metabolism_Homo sapiens_hsa004501.32589968
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30697001
38Fatty acid degradation_Homo sapiens_hsa000711.29023204
39Ribosome_Homo sapiens_hsa030101.27768235
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27302327
41Retinol metabolism_Homo sapiens_hsa008301.23164876
42Mismatch repair_Homo sapiens_hsa034301.20361507
43Nucleotide excision repair_Homo sapiens_hsa034201.19138997
44Phenylalanine metabolism_Homo sapiens_hsa003601.17115100
45Pyruvate metabolism_Homo sapiens_hsa006201.15936172
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15919149
47Base excision repair_Homo sapiens_hsa034101.15387567
48Non-homologous end-joining_Homo sapiens_hsa034501.15075561
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.14778479
50Fatty acid metabolism_Homo sapiens_hsa012121.14546998
51Histidine metabolism_Homo sapiens_hsa003401.09269785
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07674955
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.05741507
54Basal transcription factors_Homo sapiens_hsa030221.05727989
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04958654
56Vitamin B6 metabolism_Homo sapiens_hsa007501.03889885
57beta-Alanine metabolism_Homo sapiens_hsa004101.02272193
58Legionellosis_Homo sapiens_hsa051341.01487165
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00804276
60Carbon metabolism_Homo sapiens_hsa012000.99402175
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.99353994
62Tyrosine metabolism_Homo sapiens_hsa003500.99325088
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.95847701
64RNA transport_Homo sapiens_hsa030130.93082654
65mRNA surveillance pathway_Homo sapiens_hsa030150.92902066
66Sulfur relay system_Homo sapiens_hsa041220.91041539
67Biosynthesis of amino acids_Homo sapiens_hsa012300.90371894
68Oxidative phosphorylation_Homo sapiens_hsa001900.90190025
69Spliceosome_Homo sapiens_hsa030400.89147030
70Pentose phosphate pathway_Homo sapiens_hsa000300.84609445
71Rheumatoid arthritis_Homo sapiens_hsa053230.84261899
72Complement and coagulation cascades_Homo sapiens_hsa046100.81946889
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81323569
74Homologous recombination_Homo sapiens_hsa034400.80949448
75p53 signaling pathway_Homo sapiens_hsa041150.79974394
76Vitamin digestion and absorption_Homo sapiens_hsa049770.79591106
77Arachidonic acid metabolism_Homo sapiens_hsa005900.77984149
78Oocyte meiosis_Homo sapiens_hsa041140.77913948
79RNA degradation_Homo sapiens_hsa030180.76366688
80Metabolic pathways_Homo sapiens_hsa011000.72657566
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71094438
82Fructose and mannose metabolism_Homo sapiens_hsa000510.70613153
83Parkinsons disease_Homo sapiens_hsa050120.70464832
84Cell cycle_Homo sapiens_hsa041100.70445534
85Caffeine metabolism_Homo sapiens_hsa002320.69963206
86Regulation of autophagy_Homo sapiens_hsa041400.68863112
87Starch and sucrose metabolism_Homo sapiens_hsa005000.68792129
88Collecting duct acid secretion_Homo sapiens_hsa049660.65921665
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65093563
90Graft-versus-host disease_Homo sapiens_hsa053320.63400908
91Cardiac muscle contraction_Homo sapiens_hsa042600.63274425
92Vibrio cholerae infection_Homo sapiens_hsa051100.61566001
93Purine metabolism_Homo sapiens_hsa002300.60521536
94Arginine and proline metabolism_Homo sapiens_hsa003300.59990873
95Galactose metabolism_Homo sapiens_hsa000520.57398152
96PPAR signaling pathway_Homo sapiens_hsa033200.57335995
97Phagosome_Homo sapiens_hsa041450.56991644
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55733432
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54088187
100Type I diabetes mellitus_Homo sapiens_hsa049400.52333031
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51992968
102N-Glycan biosynthesis_Homo sapiens_hsa005100.49961035
103Systemic lupus erythematosus_Homo sapiens_hsa053220.48369684
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46904583
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45289635
106Staphylococcus aureus infection_Homo sapiens_hsa051500.44095460
107Huntingtons disease_Homo sapiens_hsa050160.41796817
108Epstein-Barr virus infection_Homo sapiens_hsa051690.41286883
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40900027
110Allograft rejection_Homo sapiens_hsa053300.40021769
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35005206
112Alcoholism_Homo sapiens_hsa050340.26512582
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24971570
114TGF-beta signaling pathway_Homo sapiens_hsa043500.21050224
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19983615
116Nitrogen metabolism_Homo sapiens_hsa009100.19509316
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19162308
118Sphingolipid metabolism_Homo sapiens_hsa006000.15404631
119Phototransduction_Homo sapiens_hsa047440.13658864

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