SLC25A14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.92377102
2synaptic vesicle exocytosis (GO:0016079)4.85720237
3vocalization behavior (GO:0071625)4.71183993
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.63797866
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.63050470
6protein localization to synapse (GO:0035418)4.50655427
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45705123
8synaptic transmission, glutamatergic (GO:0035249)4.36985027
9glutamate secretion (GO:0014047)4.32103918
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28302335
11neuron-neuron synaptic transmission (GO:0007270)4.25776722
12glutamate receptor signaling pathway (GO:0007215)4.23491709
13pyrimidine nucleobase catabolic process (GO:0006208)4.23128279
14synaptic vesicle maturation (GO:0016188)4.20532348
15startle response (GO:0001964)4.19917200
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.16593164
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.12731199
18regulation of glutamate receptor signaling pathway (GO:1900449)4.11997571
19presynaptic membrane assembly (GO:0097105)4.07137132
20proline transport (GO:0015824)3.99283183
21regulation of synaptic vesicle exocytosis (GO:2000300)3.97331551
22neuronal action potential propagation (GO:0019227)3.96749814
23gamma-aminobutyric acid signaling pathway (GO:0007214)3.94319692
24intraciliary transport (GO:0042073)3.93629820
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88325202
26proteasome assembly (GO:0043248)3.85551530
27epithelial cilium movement (GO:0003351)3.75995535
28presynaptic membrane organization (GO:0097090)3.74358467
29response to histamine (GO:0034776)3.66547755
30regulation of synaptic vesicle transport (GO:1902803)3.62302585
31neurotransmitter-gated ion channel clustering (GO:0072578)3.61834121
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.61274100
33regulation of glutamate secretion (GO:0014048)3.59929028
34daunorubicin metabolic process (GO:0044597)3.58749858
35polyketide metabolic process (GO:0030638)3.58749858
36doxorubicin metabolic process (GO:0044598)3.58749858
37neurotransmitter secretion (GO:0007269)3.58428952
38neuron recognition (GO:0008038)3.52144239
39long-term synaptic potentiation (GO:0060291)3.52048306
40calcium-mediated signaling using intracellular calcium source (GO:0035584)3.48251564
41nucleobase catabolic process (GO:0046113)3.46069467
42striatum development (GO:0021756)3.43625754
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42788100
44postsynaptic membrane organization (GO:0001941)3.42614407
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41370922
46synaptic vesicle endocytosis (GO:0048488)3.41247652
47behavioral defense response (GO:0002209)3.41114556
48behavioral fear response (GO:0001662)3.41114556
49regulation of cilium movement (GO:0003352)3.40561488
50positive regulation of mitochondrial fission (GO:0090141)3.40271683
51neurotransmitter transport (GO:0006836)3.34821077
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32729104
53behavioral response to nicotine (GO:0035095)3.32417893
54neurotransmitter uptake (GO:0001504)3.32289105
55locomotory exploration behavior (GO:0035641)3.29874967
56protein localization to cilium (GO:0061512)3.29851404
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27904914
58behavioral response to cocaine (GO:0048148)3.27494239
59protein deneddylation (GO:0000338)3.26303955
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.25995434
61fear response (GO:0042596)3.25870543
62energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.24537922
63ATP hydrolysis coupled proton transport (GO:0015991)3.24537922
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24473251
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24473251
66regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23955377
67regulation of postsynaptic membrane potential (GO:0060078)3.22074537
68cerebellar granule cell differentiation (GO:0021707)3.21027202
69positive regulation of synapse assembly (GO:0051965)3.20169268
70exploration behavior (GO:0035640)3.20081455
71establishment of protein localization to mitochondrial membrane (GO:0090151)3.19205475
72regulation of neuronal synaptic plasticity (GO:0048168)3.18507026
73transmission of nerve impulse (GO:0019226)3.18466981
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17369850
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15935736
76DNA double-strand break processing (GO:0000729)3.15194053
77cilium movement (GO:0003341)3.13669248
78water-soluble vitamin biosynthetic process (GO:0042364)3.12867716
79positive regulation of synapse maturation (GO:0090129)3.11209948
80protein complex biogenesis (GO:0070271)3.08747702
81nonmotile primary cilium assembly (GO:0035058)3.06516465
82cilium morphogenesis (GO:0060271)3.04661515
83protein-cofactor linkage (GO:0018065)3.03115589
84long-term memory (GO:0007616)3.01840078
85positive regulation of membrane potential (GO:0045838)3.01268622
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99254288
87axonal fasciculation (GO:0007413)2.98917982
88regulation of synaptic plasticity (GO:0048167)2.98011267
89transferrin transport (GO:0033572)2.97819453
90cilium organization (GO:0044782)2.97024840
91serotonin metabolic process (GO:0042428)2.95719505
92detection of calcium ion (GO:0005513)2.95392884
93cilium assembly (GO:0042384)2.95344687
94maintenance of protein location in nucleus (GO:0051457)2.93559027
95regulation of vesicle fusion (GO:0031338)2.93420983
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91981824
97regulation of neurotransmitter levels (GO:0001505)2.87965167
98cullin deneddylation (GO:0010388)2.87127856
99mitochondrial respiratory chain complex assembly (GO:0033108)2.86786020
100dendrite development (GO:0016358)2.86577777
101regulation of neurotransmitter secretion (GO:0046928)2.86377709
102respiratory chain complex IV assembly (GO:0008535)2.85781152
103chaperone-mediated protein transport (GO:0072321)2.85401053
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83149243
105synaptic transmission (GO:0007268)2.82811909
106organelle disassembly (GO:1903008)2.81123198
107axoneme assembly (GO:0035082)2.81030453
108gamma-aminobutyric acid transport (GO:0015812)2.80539126
109synapse assembly (GO:0007416)2.80107992
110negative regulation of amino acid transport (GO:0051956)2.78352342
111synaptic transmission, dopaminergic (GO:0001963)2.77682814
112regulation of protein kinase A signaling (GO:0010738)2.77640850
113negative regulation of neurotransmitter transport (GO:0051589)2.77008241
114energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76573576
115ATP synthesis coupled proton transport (GO:0015986)2.76573576
116sequestering of actin monomers (GO:0042989)2.76431775
117learning (GO:0007612)2.75856264
118serotonin receptor signaling pathway (GO:0007210)2.75634718
119regulation of synapse maturation (GO:0090128)2.75027355
120axonemal dynein complex assembly (GO:0070286)2.74882427
121female mating behavior (GO:0060180)2.74311987
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74283714
123membrane depolarization (GO:0051899)2.74183272
124mechanosensory behavior (GO:0007638)2.73865637
125synapse organization (GO:0050808)2.73354616
126regulation of synaptic transmission, GABAergic (GO:0032228)2.72092242
127trivalent inorganic cation transport (GO:0072512)2.71834425
128ferric iron transport (GO:0015682)2.71834425
129positive regulation of synaptic transmission (GO:0050806)2.71079020
130positive regulation of neurotransmitter transport (GO:0051590)2.70154191
131regulation of hexokinase activity (GO:1903299)2.70035489
132regulation of glucokinase activity (GO:0033131)2.70035489
133regulation of neurotransmitter transport (GO:0051588)2.69844891
134magnesium ion transport (GO:0015693)2.69116082
135regulation of mitochondrial translation (GO:0070129)2.65913643
136cytochrome complex assembly (GO:0017004)2.65202034
137hindbrain development (GO:0030902)2.62945594
138protein polyglutamylation (GO:0018095)2.62528524
139neural tube formation (GO:0001841)2.62008888
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.61988457
141NADH dehydrogenase complex assembly (GO:0010257)2.61988457
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61988457
143protein K6-linked ubiquitination (GO:0085020)2.60372627
144electron transport chain (GO:0022900)2.56501657
145respiratory electron transport chain (GO:0022904)2.56012974
146protein neddylation (GO:0045116)2.55961308
147regulation of microtubule-based movement (GO:0060632)2.55627651
148negative regulation of telomere maintenance (GO:0032205)2.55451082
149regulation of development, heterochronic (GO:0040034)2.55396047
150ubiquinone metabolic process (GO:0006743)2.54900616
151regulation of cellular amino acid metabolic process (GO:0006521)2.50180478
152mannosylation (GO:0097502)2.50100217
153platelet dense granule organization (GO:0060155)2.48332093
154DNA damage response, detection of DNA damage (GO:0042769)2.46332993
155ubiquinone biosynthetic process (GO:0006744)2.46121187
156intracellular protein transmembrane import (GO:0044743)2.44992973
157retinal ganglion cell axon guidance (GO:0031290)2.44990031
158positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.43931246
159ribonucleoprotein complex disassembly (GO:0032988)2.41858957
160glycosphingolipid biosynthetic process (GO:0006688)2.39757721
161regulation of timing of cell differentiation (GO:0048505)2.39545342
162anterograde synaptic vesicle transport (GO:0048490)2.38700525
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38051201
164resolution of meiotic recombination intermediates (GO:0000712)2.35061525
165synapsis (GO:0007129)2.34353317
1667-methylguanosine mRNA capping (GO:0006370)2.33558369
167negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.33199778
168limb bud formation (GO:0060174)2.32747671
169regulation of collateral sprouting (GO:0048670)2.31978224
170histone H2A acetylation (GO:0043968)2.31921395
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.31631116
172retinal cone cell development (GO:0046549)2.30687687
173photoreceptor cell maintenance (GO:0045494)2.29337460
174anterograde axon cargo transport (GO:0008089)2.28634858
175cell migration in hindbrain (GO:0021535)2.28387134
176negative regulation of JAK-STAT cascade (GO:0046426)2.27801040
177termination of RNA polymerase III transcription (GO:0006386)2.27580331
178transcription elongation from RNA polymerase III promoter (GO:0006385)2.27580331
179olfactory bulb development (GO:0021772)2.27228486
180RNA capping (GO:0036260)2.26765363
1817-methylguanosine RNA capping (GO:0009452)2.26765363
182DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.24981493
183dopamine transport (GO:0015872)2.24503587
184inositol phosphate catabolic process (GO:0071545)2.21657850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97045852
2GBX2_23144817_ChIP-Seq_PC3_Human3.93997526
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67992979
4ZNF274_21170338_ChIP-Seq_K562_Hela3.35837645
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.91361008
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91260764
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77262657
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74474139
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67379831
10REST_21632747_ChIP-Seq_MESCs_Mouse2.65847203
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65645960
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.59802021
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45684526
14TAF15_26573619_Chip-Seq_HEK293_Human2.37539846
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35534699
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35534699
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35489990
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31853909
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.29448073
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28649041
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18819966
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18432618
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.15967857
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.15957055
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14024896
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11590867
27IGF1R_20145208_ChIP-Seq_DFB_Human2.06544134
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06409347
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06250558
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.03820748
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03654734
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03305008
33RNF2_27304074_Chip-Seq_NSC_Mouse2.01116238
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98885723
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97002823
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.94353841
37EWS_26573619_Chip-Seq_HEK293_Human1.93443607
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93001004
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92414109
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.91128759
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88044972
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.86368831
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85347695
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84177710
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.75692914
46ELK1_19687146_ChIP-ChIP_HELA_Human1.75006708
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.71076180
48VDR_23849224_ChIP-Seq_CD4+_Human1.70628447
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68708559
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68486706
51SMAD4_21799915_ChIP-Seq_A2780_Human1.65319583
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62122934
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62122934
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62122934
55VDR_22108803_ChIP-Seq_LS180_Human1.61291385
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.57278010
57P300_19829295_ChIP-Seq_ESCs_Human1.55889095
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54113797
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51648695
60FUS_26573619_Chip-Seq_HEK293_Human1.50824930
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48215755
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42566028
63IRF1_19129219_ChIP-ChIP_H3396_Human1.42520563
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37186957
65MYC_18940864_ChIP-ChIP_HL60_Human1.36070585
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31006821
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30356527
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.30240247
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.28820243
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28771308
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28195757
72TP53_22573176_ChIP-Seq_HFKS_Human1.27607902
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26430663
74CBP_20019798_ChIP-Seq_JUKART_Human1.26430663
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26281717
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25579143
77STAT3_23295773_ChIP-Seq_U87_Human1.24913832
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24626952
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23524078
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.23310105
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22826075
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.22648874
83GABP_19822575_ChIP-Seq_HepG2_Human1.20990378
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.20856208
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20742168
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20707883
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20230911
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19556603
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17988080
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17016058
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16533882
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15102855
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14768643
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14675683
95DROSHA_22980978_ChIP-Seq_HELA_Human1.14525429
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12258093
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12189477
98JUN_21703547_ChIP-Seq_K562_Human1.12032570
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11926497
100AR_25329375_ChIP-Seq_VCAP_Human1.11735496
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10684241
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10437443
103RUNX2_22187159_ChIP-Seq_PCA_Human1.09314385
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07873906
105AR_21572438_ChIP-Seq_LNCaP_Human1.07638920
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.07377319
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07160749
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.06701350
109FOXP3_21729870_ChIP-Seq_TREG_Human1.06426767
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05471552
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05325982
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05281894
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05190789
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04219996
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04069947
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04069947
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01686872
118TCF4_23295773_ChIP-Seq_U87_Human1.00712904
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.00710690
120NANOG_19829295_ChIP-Seq_ESCs_Human1.00496373
121SOX2_19829295_ChIP-Seq_ESCs_Human1.00496373
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00434433
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00000891
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98667609
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97908286
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.96915900
127DCP1A_22483619_ChIP-Seq_HELA_Human0.96562085
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95641831
129* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95505353
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.94166582
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93800704
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93482349
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.93170017
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92934309
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92761849
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92629308
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.92332854
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.92046985
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92010285
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91750987
141AR_19668381_ChIP-Seq_PC3_Human0.91650424
142ER_23166858_ChIP-Seq_MCF-7_Human0.91416327
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91373080
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.87830972
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87465295
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87102773
147AHR_22903824_ChIP-Seq_MCF-7_Human0.86955373
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86600976
149WT1_19549856_ChIP-ChIP_CCG9911_Human0.86193942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.02030077
2MP0004859_abnormal_synaptic_plasticity4.39013658
3MP0003635_abnormal_synaptic_transmissio3.44168084
4MP0004270_analgesia3.22308650
5MP0009745_abnormal_behavioral_response3.05393038
6MP0002064_seizures2.93975980
7MP0002063_abnormal_learning/memory/cond2.93255245
8MP0009046_muscle_twitch2.90148464
9MP0002102_abnormal_ear_morphology2.82529695
10MP0003122_maternal_imprinting2.81334529
11MP0002572_abnormal_emotion/affect_behav2.79889717
12MP0001968_abnormal_touch/_nociception2.79041662
13MP0008877_abnormal_DNA_methylation2.68551149
14MP0002272_abnormal_nervous_system2.58951254
15MP0003787_abnormal_imprinting2.47412297
16MP0001486_abnormal_startle_reflex2.44084598
17MP0006276_abnormal_autonomic_nervous2.41563799
18MP0002734_abnormal_mechanical_nocicepti2.40610688
19MP0002736_abnormal_nociception_after2.39931119
20MP0001501_abnormal_sleep_pattern2.27871708
21MP0001440_abnormal_grooming_behavior2.20025343
22MP0001529_abnormal_vocalization2.12632105
23MP0004858_abnormal_nervous_system2.12431455
24MP0002822_catalepsy2.11071009
25MP0002735_abnormal_chemical_nociception2.04660809
26MP0006292_abnormal_olfactory_placode2.04319529
27MP0005394_taste/olfaction_phenotype2.01578697
28MP0005499_abnormal_olfactory_system2.01578697
29MP0002733_abnormal_thermal_nociception1.95205092
30MP0002067_abnormal_sensory_capabilities1.92992336
31MP0001970_abnormal_pain_threshold1.85915003
32MP0001984_abnormal_olfaction1.84148367
33MP0001905_abnormal_dopamine_level1.81955948
34MP0000569_abnormal_digit_pigmentation1.78478002
35MP0002184_abnormal_innervation1.74893481
36MP0005646_abnormal_pituitary_gland1.74343228
37MP0005423_abnormal_somatic_nervous1.73477647
38MP0000778_abnormal_nervous_system1.71475387
39MP0003121_genomic_imprinting1.71459167
40MP0002909_abnormal_adrenal_gland1.66730424
41MP0008058_abnormal_DNA_repair1.66551548
42MP0002557_abnormal_social/conspecific_i1.60341102
43MP0005386_behavior/neurological_phenoty1.60019402
44MP0004924_abnormal_behavior1.60019402
45MP0001188_hyperpigmentation1.51543538
46MP0004142_abnormal_muscle_tone1.50757374
47MP0002928_abnormal_bile_duct1.48720954
48MP0009780_abnormal_chondrocyte_physiolo1.41448181
49MP0010386_abnormal_urinary_bladder1.40351226
50MP0000955_abnormal_spinal_cord1.35860106
51MP0005084_abnormal_gallbladder_morpholo1.34302661
52MP0003183_abnormal_peptide_metabolism1.33838989
53MP0002882_abnormal_neuron_morphology1.32212130
54MP0002234_abnormal_pharynx_morphology1.31746793
55MP0002066_abnormal_motor_capabilities/c1.24695004
56MP0004811_abnormal_neuron_physiology1.24308271
57MP0008995_early_reproductive_senescence1.23922049
58MP0002653_abnormal_ependyma_morphology1.23135082
59MP0005645_abnormal_hypothalamus_physiol1.22430759
60MP0004043_abnormal_pH_regulation1.22272625
61MP0003195_calcinosis1.20576683
62MP0002638_abnormal_pupillary_reflex1.19857055
63MP0003879_abnormal_hair_cell1.18713615
64MP0002837_dystrophic_cardiac_calcinosis1.18321535
65MP0002160_abnormal_reproductive_system1.17528887
66MP0003329_amyloid_beta_deposits1.16241553
67MP0006035_abnormal_mitochondrial_morpho1.15893648
68MP0008875_abnormal_xenobiotic_pharmacok1.15312828
69MP0000631_abnormal_neuroendocrine_gland1.15074311
70MP0002332_abnormal_exercise_endurance1.11408901
71MP0003890_abnormal_embryonic-extraembry1.11393609
72MP0005551_abnormal_eye_electrophysiolog1.10485807
73MP0003136_yellow_coat_color1.09732217
74MP0008569_lethality_at_weaning1.06331241
75MP0002752_abnormal_somatic_nervous1.02596365
76MP0002277_abnormal_respiratory_mucosa1.01123339
77MP0002152_abnormal_brain_morphology1.01016120
78MP0002876_abnormal_thyroid_physiology1.00370288
79MP0003938_abnormal_ear_development0.99893183
80MP0001963_abnormal_hearing_physiology0.99814428
81MP0002229_neurodegeneration0.98785862
82MP0002090_abnormal_vision0.98678339
83MP0003937_abnormal_limbs/digits/tail_de0.98217722
84MP0003718_maternal_effect0.97572782
85MP0008872_abnormal_physiological_respon0.96103196
86MP0004215_abnormal_myocardial_fiber0.93443411
87MP0008789_abnormal_olfactory_epithelium0.91699186
88MP0003123_paternal_imprinting0.91317924
89MP0003011_delayed_dark_adaptation0.90846964
90MP0004085_abnormal_heartbeat0.90266076
91MP0001929_abnormal_gametogenesis0.89986027
92MP0005171_absent_coat_pigmentation0.89049545
93MP0002210_abnormal_sex_determination0.88841644
94MP0004742_abnormal_vestibular_system0.88715978
95MP0000647_abnormal_sebaceous_gland0.88656675
96MP0000427_abnormal_hair_cycle0.87390114
97MP0003698_abnormal_male_reproductive0.86842749
98MP0001502_abnormal_circadian_rhythm0.85901426
99MP0006036_abnormal_mitochondrial_physio0.85125691
100MP0000049_abnormal_middle_ear0.83173234
101MP0005195_abnormal_posterior_eye0.83150749
102MP0002751_abnormal_autonomic_nervous0.82286380
103MP0002069_abnormal_eating/drinking_beha0.81638734
104MP0004145_abnormal_muscle_electrophysio0.81418870
105MP0000026_abnormal_inner_ear0.81397349
106MP0003119_abnormal_digestive_system0.81326425
107MP0002233_abnormal_nose_morphology0.81197304
108MP0005379_endocrine/exocrine_gland_phen0.80928791
109MP0002938_white_spotting0.80911866
110MP0006072_abnormal_retinal_apoptosis0.80213146
111MP0002127_abnormal_cardiovascular_syste0.80196070
112MP0001986_abnormal_taste_sensitivity0.78297250
113MP0003633_abnormal_nervous_system0.78153200
114MP0004264_abnormal_extraembryonic_tissu0.75087616
115MP0004885_abnormal_endolymph0.74282880
116MP0003137_abnormal_impulse_conducting0.72165260
117MP0004133_heterotaxia0.71973077
118MP0003631_nervous_system_phenotype0.70618914
119MP0001664_abnormal_digestion0.68855515
120MP0002163_abnormal_gland_morphology0.68179698
121MP0003634_abnormal_glial_cell0.67698496
122MP0008874_decreased_physiological_sensi0.64690432
123MP0003861_abnormal_nervous_system0.63985506
124MP0001485_abnormal_pinna_reflex0.62584595
125MP0005535_abnormal_body_temperature0.61122503
126MP0003632_abnormal_nervous_system0.58977833
127MP0005253_abnormal_eye_physiology0.58875397
128MP0002254_reproductive_system_inflammat0.58859817
129MP0001943_abnormal_respiration0.58507117
130MP0003283_abnormal_digestive_organ0.56795691

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.69737151
2Atonic seizures (HP:0010819)4.94297847
3Hyperventilation (HP:0002883)4.84955330
4Epileptic encephalopathy (HP:0200134)4.73944570
5Focal seizures (HP:0007359)4.70558064
6Febrile seizures (HP:0002373)4.56561955
7Myokymia (HP:0002411)4.02944889
8Dialeptic seizures (HP:0011146)3.99369794
9Absence seizures (HP:0002121)3.84956740
10Pancreatic fibrosis (HP:0100732)3.64843395
11Visual hallucinations (HP:0002367)3.63850111
12Pancreatic cysts (HP:0001737)3.61998606
13Amblyopia (HP:0000646)3.61906980
14True hermaphroditism (HP:0010459)3.54358605
15Hepatoblastoma (HP:0002884)3.52229216
16Bilateral microphthalmos (HP:0007633)3.42290693
17Generalized tonic-clonic seizures (HP:0002069)3.36855452
18Hypochromic microcytic anemia (HP:0004840)3.32949728
19Nephronophthisis (HP:0000090)3.28059979
20Gait imbalance (HP:0002141)3.23920870
21Congenital primary aphakia (HP:0007707)3.02121828
22Medial flaring of the eyebrow (HP:0010747)2.91031614
23Sensory axonal neuropathy (HP:0003390)2.89402174
24Nephrogenic diabetes insipidus (HP:0009806)2.85796240
25Abnormality of the renal medulla (HP:0100957)2.82732666
26Acute necrotizing encephalopathy (HP:0006965)2.81164606
27Hepatocellular necrosis (HP:0001404)2.79018084
28Hepatic necrosis (HP:0002605)2.72577533
29Hypothermia (HP:0002045)2.66442962
30Abnormality of the lower motor neuron (HP:0002366)2.65833176
31Broad-based gait (HP:0002136)2.65637955
32Hemiparesis (HP:0001269)2.62155665
33Drooling (HP:0002307)2.57661686
34Excessive salivation (HP:0003781)2.57661686
35Methylmalonic acidemia (HP:0002912)2.54757753
36Horizontal nystagmus (HP:0000666)2.51076421
37Abnormal mitochondria in muscle tissue (HP:0008316)2.50562681
38Inability to walk (HP:0002540)2.50481284
39Progressive cerebellar ataxia (HP:0002073)2.45988089
40Hyperglycinemia (HP:0002154)2.43208151
41Increased hepatocellular lipid droplets (HP:0006565)2.41435565
42Occipital encephalocele (HP:0002085)2.41419259
43Progressive macrocephaly (HP:0004481)2.40880143
44Chronic hepatic failure (HP:0100626)2.40514988
45Abnormal ciliary motility (HP:0012262)2.36158928
46Protruding tongue (HP:0010808)2.35942717
47Abnormality of glycolysis (HP:0004366)2.33847663
48Increased serum pyruvate (HP:0003542)2.33847663
49Cystic liver disease (HP:0006706)2.33360852
50Abnormality of the renal cortex (HP:0011035)2.33111872
51Lipid accumulation in hepatocytes (HP:0006561)2.32120389
52Blue irides (HP:0000635)2.30378656
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.29016063
54Specific learning disability (HP:0001328)2.28346405
55Poor coordination (HP:0002370)2.27993367
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23681448
57Genital tract atresia (HP:0001827)2.22866468
58Abnormality of the corticospinal tract (HP:0002492)2.22619654
59Vaginal atresia (HP:0000148)2.22350659
60Abnormal hair whorl (HP:0010721)2.21877187
61Absent speech (HP:0001344)2.20992119
62Abnormal respiratory motile cilium physiology (HP:0012261)2.18585753
63Generalized myoclonic seizures (HP:0002123)2.17761678
64Amyotrophic lateral sclerosis (HP:0007354)2.16083403
65Delayed gross motor development (HP:0002194)2.15588377
66Mitochondrial inheritance (HP:0001427)2.14566934
67Generalized hypotonia (HP:0001290)2.13608935
68Abnormal biliary tract physiology (HP:0012439)2.12786093
69Bile duct proliferation (HP:0001408)2.12786093
70Limb dystonia (HP:0002451)2.12697796
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.11819633
72Sclerocornea (HP:0000647)2.10381854
73Epileptiform EEG discharges (HP:0011182)2.08437089
74Failure to thrive in infancy (HP:0001531)2.07746895
75Type II lissencephaly (HP:0007260)2.06673374
76Postaxial hand polydactyly (HP:0001162)2.06490011
77Curly hair (HP:0002212)2.06032625
78Renal cortical cysts (HP:0000803)2.05602370
79Resting tremor (HP:0002322)2.04920512
80Acute encephalopathy (HP:0006846)2.03646591
81Progressive inability to walk (HP:0002505)2.03538144
82Methylmalonic aciduria (HP:0012120)2.02410139
83Hypoplastic pelvis (HP:0008839)2.02243314
84Poor suck (HP:0002033)2.01826642
85Optic disc pallor (HP:0000543)2.01477941
86Renal Fanconi syndrome (HP:0001994)1.99907636
87Pheochromocytoma (HP:0002666)1.99590863
88Dysdiadochokinesis (HP:0002075)1.99429636
89Delusions (HP:0000746)1.99209425
90Postaxial foot polydactyly (HP:0001830)1.98706822
91Bifid tongue (HP:0010297)1.98115306
92Broad foot (HP:0001769)1.97414340
93Cerebral hypomyelination (HP:0006808)1.96195849
94Abnormality of the labia minora (HP:0012880)1.96064672
95Cerebral edema (HP:0002181)1.95356728
96Abnormal eating behavior (HP:0100738)1.93690450
97Anencephaly (HP:0002323)1.93513128
98Lissencephaly (HP:0001339)1.92750877
99Dysmetria (HP:0001310)1.92594595
100Tubulointerstitial nephritis (HP:0001970)1.92259392
101Increased CSF lactate (HP:0002490)1.92033279
102Atelectasis (HP:0100750)1.91869707
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.91811513
104Hypoplasia of the fovea (HP:0007750)1.91811513
105Narrow forehead (HP:0000341)1.91414870
106Supranuclear gaze palsy (HP:0000605)1.89741087
107Oculomotor apraxia (HP:0000657)1.89124109
108Truncal ataxia (HP:0002078)1.88839977
109Polyphagia (HP:0002591)1.88720091
110Absent/shortened dynein arms (HP:0200106)1.87166507
111Dynein arm defect of respiratory motile cilia (HP:0012255)1.87166507
112EEG with generalized epileptiform discharges (HP:0011198)1.85958901
113Neuroendocrine neoplasm (HP:0100634)1.85908132
114Anxiety (HP:0000739)1.85903243
115Gaze-evoked nystagmus (HP:0000640)1.84939047
116Congenital hepatic fibrosis (HP:0002612)1.83793972
117Muscular hypotonia of the trunk (HP:0008936)1.83253339
118Prominent nasal bridge (HP:0000426)1.83082632
119Abnormality of the metopic suture (HP:0005556)1.82930945
1203-Methylglutaconic aciduria (HP:0003535)1.82796969
121Supernumerary spleens (HP:0009799)1.82491571
122Depression (HP:0000716)1.80486348
123Exotropia (HP:0000577)1.79388159
124Male pseudohermaphroditism (HP:0000037)1.79135364
125Status epilepticus (HP:0002133)1.77365607
126Volvulus (HP:0002580)1.76066699
127Abnormal respiratory motile cilium morphology (HP:0005938)1.75497545
128Abnormal respiratory epithelium morphology (HP:0012253)1.75497545
129Short tibia (HP:0005736)1.75007421
130Pendular nystagmus (HP:0012043)1.74648196
131Abnormality of salivation (HP:0100755)1.74297204
132Aplasia/Hypoplasia of the lens (HP:0008063)1.73963946
133Dandy-Walker malformation (HP:0001305)1.73419161
134Impaired vibration sensation in the lower limbs (HP:0002166)1.73300398
135Retinal dysplasia (HP:0007973)1.73155260
136Scrotal hypoplasia (HP:0000046)1.72830104
137Oligodactyly (hands) (HP:0001180)1.71460740
138Intestinal atresia (HP:0011100)1.70696733
139Prominent metopic ridge (HP:0005487)1.70377317
140Aganglionic megacolon (HP:0002251)1.70366468
141Tented upper lip vermilion (HP:0010804)1.69824971
142Hypsarrhythmia (HP:0002521)1.69811376
143Abnormality of the fovea (HP:0000493)1.69312310
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69227727
145Abnormal protein N-linked glycosylation (HP:0012347)1.69227727
146Abnormal protein glycosylation (HP:0012346)1.69227727
147Abnormal glycosylation (HP:0012345)1.69227727
148Lactic acidosis (HP:0003128)1.69157020
149Increased serum lactate (HP:0002151)1.68378890
150Poor eye contact (HP:0000817)1.67490242
151Rhinitis (HP:0012384)1.67460568
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.67350727
153Hyperthyroidism (HP:0000836)1.66377238
154X-linked dominant inheritance (HP:0001423)1.65826649
155Molar tooth sign on MRI (HP:0002419)1.65660355
156Abnormality of midbrain morphology (HP:0002418)1.65660355
157Progressive external ophthalmoplegia (HP:0000590)1.65235676
158Ragged-red muscle fibers (HP:0003200)1.64674827
159Nephroblastoma (Wilms tumor) (HP:0002667)1.64253060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.24873842
2GRK53.78913830
3CASK3.77198028
4EPHA43.66728939
5MAP3K122.97485005
6MAP3K42.79216234
7MAP4K22.71064988
8MAP3K92.59231960
9MAP2K72.54764531
10FRK2.46449279
11BCKDK2.43059163
12GRK62.38377795
13ADRBK22.33790888
14MAP2K42.31621896
15GRK72.21091458
16TRIM282.19015097
17VRK22.13443247
18ERBB32.11290921
19PRPF4B2.02319238
20AKT31.97084788
21MINK11.86947565
22SRPK11.82111869
23MARK11.72673134
24CDK191.71826658
25PLK21.70376963
26RIPK41.69756337
27NTRK11.65182795
28NUAK11.63999560
29VRK11.63272826
30ARAF1.60550195
31DYRK31.59852838
32STK161.51698989
33CDK121.50994004
34CSNK1G11.47719665
35DAPK21.47417953
36NTRK21.46949816
37PNCK1.45103247
38DAPK11.42390235
39OXSR11.38851538
40LMTK21.38076870
41TAF11.37479112
42PLK31.35720041
43LIMK11.31946804
44EIF2AK31.28850616
45NME11.27382355
46BMPR21.25416735
47MAPK131.23475548
48MOS1.14541062
49PRKCG1.12922885
50CDK51.11851131
51TYRO31.11818544
52GRK11.11286037
53ADRBK11.08310948
54MAPK71.08043756
55KSR11.07265040
56TNIK1.06875911
57CAMK2A1.06738435
58ICK1.06629285
59MKNK21.06373062
60WNK11.03882356
61PAK61.03466605
62KSR21.02585363
63STK38L0.99858845
64RPS6KA40.96349770
65CAMK2B0.93137333
66BRAF0.90975237
67ZAK0.90378192
68WEE10.88992078
69CDK180.84421126
70NEK10.82725853
71EIF2AK10.80182005
72WNK30.80122138
73BCR0.79260542
74CSNK1G20.79163070
75CDK140.79055444
76CDK150.78772757
77UHMK10.77331022
78SIK30.77254705
79MAPK150.76948755
80FES0.75239933
81MARK20.74884992
82DYRK1A0.74271614
83BUB10.74204594
84FGR0.73947107
85PLK10.73020199
86PTK2B0.71851536
87PHKG10.71336409
88PHKG20.71336409
89CSNK1G30.70495621
90STK390.70089516
91TIE10.69063121
92CDK11A0.66676379
93CAMK40.66002792
94PAK30.65381321
95MKNK10.62798005
96SGK2230.60821557
97SGK4940.60821557
98MAP3K20.58832289
99SIK20.56662301
100CCNB10.54246137
101PRKCE0.53083800
102TSSK60.52536235
103BRD40.52404712
104CSNK1A1L0.51346072
105PRKD30.50387133
106PDK30.49365514
107PDK40.49365514
108PINK10.47019490
109CSF1R0.46994830
110MST40.46342890
111CDK80.45816745
112CSNK1D0.45629230
113INSRR0.45503238
114CAMK2D0.44798688
115PRKACA0.44715966
116CAMKK20.44031154
117MATK0.43458070
118SGK20.42787551
119DYRK20.41762378
120LATS20.41092840
121TNK20.40478907
122BRSK20.40306028
123AURKA0.40202712
124CAMK10.39907328
125TESK10.39529271
126RAF10.39136212
127BMPR1B0.38067795
128PLK40.37438761
129ATR0.37080055
130MAPKAPK30.36774829
131WNK40.36718763
132ATM0.36579018
133MAPK120.36540439
134CSNK1A10.36409394
135CAMK2G0.36147937
136MAP3K130.35209915
137MAP3K60.34093462
138RPS6KA30.34078779
139FER0.34010750
140MAPK100.33742670
141MUSK0.33709652
142CDK30.33507521
143EPHA30.33108929
144TAOK30.32852089

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.49748233
2Synaptic vesicle cycle_Homo sapiens_hsa047213.33218249
3Proteasome_Homo sapiens_hsa030502.90626639
4Collecting duct acid secretion_Homo sapiens_hsa049662.86796981
5GABAergic synapse_Homo sapiens_hsa047272.76582958
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75139827
7Oxidative phosphorylation_Homo sapiens_hsa001902.59989422
8Long-term potentiation_Homo sapiens_hsa047202.55175930
9Glutamatergic synapse_Homo sapiens_hsa047242.53529993
10Amphetamine addiction_Homo sapiens_hsa050312.48193665
11Butanoate metabolism_Homo sapiens_hsa006502.43704880
12Taste transduction_Homo sapiens_hsa047422.40737393
13Morphine addiction_Homo sapiens_hsa050322.36961229
14Circadian entrainment_Homo sapiens_hsa047132.36296125
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.36187813
16RNA polymerase_Homo sapiens_hsa030202.30714039
17Olfactory transduction_Homo sapiens_hsa047402.17583580
18Serotonergic synapse_Homo sapiens_hsa047262.13816318
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06925113
20Basal transcription factors_Homo sapiens_hsa030222.06332635
21Dopaminergic synapse_Homo sapiens_hsa047282.00359936
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92403732
23Propanoate metabolism_Homo sapiens_hsa006401.90477031
24Salivary secretion_Homo sapiens_hsa049701.86920169
25Fatty acid elongation_Homo sapiens_hsa000621.86027208
26Parkinsons disease_Homo sapiens_hsa050121.85598962
27Steroid biosynthesis_Homo sapiens_hsa001001.82643430
28Alzheimers disease_Homo sapiens_hsa050101.81748911
29Long-term depression_Homo sapiens_hsa047301.75724040
30Fanconi anemia pathway_Homo sapiens_hsa034601.71341941
31Insulin secretion_Homo sapiens_hsa049111.69899111
32Cocaine addiction_Homo sapiens_hsa050301.69700540
33Vibrio cholerae infection_Homo sapiens_hsa051101.65784494
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60794545
35Calcium signaling pathway_Homo sapiens_hsa040201.60076750
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59805980
37Renin secretion_Homo sapiens_hsa049241.59328217
38Vitamin B6 metabolism_Homo sapiens_hsa007501.54278637
39Cardiac muscle contraction_Homo sapiens_hsa042601.47656256
40Homologous recombination_Homo sapiens_hsa034401.46648758
41Selenocompound metabolism_Homo sapiens_hsa004501.44051612
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.41191337
43Cholinergic synapse_Homo sapiens_hsa047251.38869193
44Huntingtons disease_Homo sapiens_hsa050161.37676199
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36836227
46GnRH signaling pathway_Homo sapiens_hsa049121.36777210
47RNA degradation_Homo sapiens_hsa030181.33239461
48Non-homologous end-joining_Homo sapiens_hsa034501.32358875
49Oxytocin signaling pathway_Homo sapiens_hsa049211.28918128
50Phototransduction_Homo sapiens_hsa047441.27331056
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27019313
52Gastric acid secretion_Homo sapiens_hsa049711.26956916
53Sulfur metabolism_Homo sapiens_hsa009201.26341768
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25155594
55Gap junction_Homo sapiens_hsa045401.18097260
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17877177
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12670813
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12327297
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11241708
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09071704
61RNA transport_Homo sapiens_hsa030131.08486617
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08247412
63Folate biosynthesis_Homo sapiens_hsa007901.08086123
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05837395
65Base excision repair_Homo sapiens_hsa034101.04821255
66Pyrimidine metabolism_Homo sapiens_hsa002401.04155489
67Peroxisome_Homo sapiens_hsa041461.03970339
68cAMP signaling pathway_Homo sapiens_hsa040241.03851740
69Dorso-ventral axis formation_Homo sapiens_hsa043200.98135156
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.97892105
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95971772
72Mismatch repair_Homo sapiens_hsa034300.95136291
73Purine metabolism_Homo sapiens_hsa002300.93829994
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91657003
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91451535
76Axon guidance_Homo sapiens_hsa043600.89401078
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87799351
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86173510
79ErbB signaling pathway_Homo sapiens_hsa040120.85212147
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82267176
81Estrogen signaling pathway_Homo sapiens_hsa049150.81524465
82One carbon pool by folate_Homo sapiens_hsa006700.79285851
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.78597384
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78154033
85Spliceosome_Homo sapiens_hsa030400.77326488
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74589365
87Metabolic pathways_Homo sapiens_hsa011000.73347501
88Tryptophan metabolism_Homo sapiens_hsa003800.72903001
89Melanogenesis_Homo sapiens_hsa049160.72315734
90Choline metabolism in cancer_Homo sapiens_hsa052310.71934263
91Nucleotide excision repair_Homo sapiens_hsa034200.71454115
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.70991198
93Glioma_Homo sapiens_hsa052140.70666321
94Oocyte meiosis_Homo sapiens_hsa041140.66322443
95Rheumatoid arthritis_Homo sapiens_hsa053230.65482257
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63023731
97Fructose and mannose metabolism_Homo sapiens_hsa000510.62423459
98Alcoholism_Homo sapiens_hsa050340.62092723
99Regulation of autophagy_Homo sapiens_hsa041400.60034134
100Ras signaling pathway_Homo sapiens_hsa040140.59430387
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59197985
102beta-Alanine metabolism_Homo sapiens_hsa004100.58382042
103MAPK signaling pathway_Homo sapiens_hsa040100.57726292
104Fatty acid metabolism_Homo sapiens_hsa012120.57614569
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.57005849
106Pyruvate metabolism_Homo sapiens_hsa006200.54848804
107Inositol phosphate metabolism_Homo sapiens_hsa005620.54642094
108Ether lipid metabolism_Homo sapiens_hsa005650.52667391
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51670239
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51617556
111Sulfur relay system_Homo sapiens_hsa041220.51587790
112N-Glycan biosynthesis_Homo sapiens_hsa005100.50688163
113Wnt signaling pathway_Homo sapiens_hsa043100.49786703
114Ovarian steroidogenesis_Homo sapiens_hsa049130.48540070
115Type I diabetes mellitus_Homo sapiens_hsa049400.47563433
116Cell cycle_Homo sapiens_hsa041100.47503605
117DNA replication_Homo sapiens_hsa030300.47132612
118mRNA surveillance pathway_Homo sapiens_hsa030150.46639223
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44287698
120Caffeine metabolism_Homo sapiens_hsa002320.44233057
121Glutathione metabolism_Homo sapiens_hsa004800.44216166
122Pancreatic secretion_Homo sapiens_hsa049720.41539984
123Type II diabetes mellitus_Homo sapiens_hsa049300.39085355
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38599009
125Dilated cardiomyopathy_Homo sapiens_hsa054140.38328298
126Rap1 signaling pathway_Homo sapiens_hsa040150.38228125
127Hedgehog signaling pathway_Homo sapiens_hsa043400.38145252
128African trypanosomiasis_Homo sapiens_hsa051430.37737468
129Phagosome_Homo sapiens_hsa041450.36639834
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.34449036
131Renal cell carcinoma_Homo sapiens_hsa052110.32881794
132Arginine and proline metabolism_Homo sapiens_hsa003300.31854109
133Endometrial cancer_Homo sapiens_hsa052130.30925292
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30398765
135Thyroid hormone synthesis_Homo sapiens_hsa049180.29387961
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29337089
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28210305
138Circadian rhythm_Homo sapiens_hsa047100.27976948
139Protein export_Homo sapiens_hsa030600.27301331
140Tight junction_Homo sapiens_hsa045300.26745633
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26590095
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26182114
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26073044
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25294647
145Glucagon signaling pathway_Homo sapiens_hsa049220.25184521
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24260467
147Linoleic acid metabolism_Homo sapiens_hsa005910.23864068
148Arachidonic acid metabolism_Homo sapiens_hsa005900.23402917
149mTOR signaling pathway_Homo sapiens_hsa041500.21968081
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.21796309
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.21052034
152Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20883641
153VEGF signaling pathway_Homo sapiens_hsa043700.20589846
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19204630
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18311671

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »