SLC25A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.45807090
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.45807090
3L-phenylalanine metabolic process (GO:0006558)6.32621037
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.32621037
5alpha-linolenic acid metabolic process (GO:0036109)6.12268492
6proline biosynthetic process (GO:0006561)5.66170280
7sulfur amino acid catabolic process (GO:0000098)5.24005287
8aromatic amino acid family catabolic process (GO:0009074)5.23832341
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.15005178
10glyoxylate metabolic process (GO:0046487)4.76786905
11cysteine metabolic process (GO:0006534)4.75998369
12acetyl-CoA metabolic process (GO:0006084)4.73226657
13bile acid biosynthetic process (GO:0006699)4.55809747
14low-density lipoprotein particle clearance (GO:0034383)4.55029007
15ethanol oxidation (GO:0006069)4.53249171
16plasma lipoprotein particle clearance (GO:0034381)4.51677973
17regulation of triglyceride catabolic process (GO:0010896)4.50968574
18valine metabolic process (GO:0006573)4.46827701
19complement activation, alternative pathway (GO:0006957)4.43485978
20proline metabolic process (GO:0006560)4.43063173
21urea cycle (GO:0000050)4.42160000
22urea metabolic process (GO:0019627)4.42160000
23protein retention in ER lumen (GO:0006621)4.41429019
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.39028680
25Golgi transport vesicle coating (GO:0048200)4.35822325
26COPI coating of Golgi vesicle (GO:0048205)4.35822325
27* fatty-acyl-CoA biosynthetic process (GO:0046949)4.22176710
28kynurenine metabolic process (GO:0070189)4.21654984
29protein carboxylation (GO:0018214)4.21434546
30peptidyl-glutamic acid carboxylation (GO:0017187)4.21434546
31indole-containing compound catabolic process (GO:0042436)4.17969962
32indolalkylamine catabolic process (GO:0046218)4.17969962
33tryptophan catabolic process (GO:0006569)4.17969962
34nitrogen cycle metabolic process (GO:0071941)4.15834333
35triglyceride homeostasis (GO:0070328)4.15615318
36acylglycerol homeostasis (GO:0055090)4.15615318
37L-serine metabolic process (GO:0006563)4.15423829
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.11165789
39negative regulation of fibrinolysis (GO:0051918)4.10989230
40high-density lipoprotein particle remodeling (GO:0034375)4.10633956
41* thioester biosynthetic process (GO:0035384)4.05902775
42* acyl-CoA biosynthetic process (GO:0071616)4.05902775
43lysine metabolic process (GO:0006553)4.05179996
44lysine catabolic process (GO:0006554)4.05179996
45biotin metabolic process (GO:0006768)4.04935569
46GDP-mannose metabolic process (GO:0019673)4.01846643
47NADH metabolic process (GO:0006734)3.99111442
48bile acid metabolic process (GO:0008206)3.97161038
49* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.95667278
50tryptophan metabolic process (GO:0006568)3.94682274
51regulation of protein activation cascade (GO:2000257)3.94092290
52serine family amino acid catabolic process (GO:0009071)3.93446694
53fatty acid beta-oxidation (GO:0006635)3.91877941
54tyrosine metabolic process (GO:0006570)3.90783220
55coenzyme catabolic process (GO:0009109)3.85233393
56amino-acid betaine metabolic process (GO:0006577)3.84659930
57regulation of cholesterol homeostasis (GO:2000188)3.81814655
58short-chain fatty acid metabolic process (GO:0046459)3.81233295
59aromatic amino acid family metabolic process (GO:0009072)3.80949339
60protein maturation by protein folding (GO:0022417)3.78851302
61fatty acid oxidation (GO:0019395)3.78215610
62regulation of fibrinolysis (GO:0051917)3.77875089
63cellular ketone body metabolic process (GO:0046950)3.75099652
64fatty acid catabolic process (GO:0009062)3.73662500
65regulation of complement activation (GO:0030449)3.73594416
66alpha-amino acid catabolic process (GO:1901606)3.73390438
67triglyceride catabolic process (GO:0019433)3.73368568
68homocysteine metabolic process (GO:0050667)3.72335275
69lipid oxidation (GO:0034440)3.69622936
70* fatty-acyl-CoA metabolic process (GO:0035337)3.69530413
71negative regulation of sterol transport (GO:0032372)3.69305268
72negative regulation of cholesterol transport (GO:0032375)3.69305268
73plasma lipoprotein particle remodeling (GO:0034369)3.67147205
74protein-lipid complex remodeling (GO:0034368)3.67147205
75macromolecular complex remodeling (GO:0034367)3.67147205
76positive regulation of lipid catabolic process (GO:0050996)3.66060351
77positive regulation of triglyceride metabolic process (GO:0090208)3.64937727
78reverse cholesterol transport (GO:0043691)3.63278481
79acylglycerol catabolic process (GO:0046464)3.63155939
80neutral lipid catabolic process (GO:0046461)3.63155939
81regulation of cholesterol esterification (GO:0010872)3.63034528
82cellular amino acid catabolic process (GO:0009063)3.62816448
83positive regulation of lipoprotein lipase activity (GO:0051006)3.61669110
84positive regulation of triglyceride lipase activity (GO:0061365)3.61669110
85regulation of translational fidelity (GO:0006450)3.60130149
86branched-chain amino acid catabolic process (GO:0009083)3.59956451
87fatty acid transmembrane transport (GO:1902001)3.58751679
88glycine metabolic process (GO:0006544)3.58331696
89coenzyme A metabolic process (GO:0015936)3.57161926
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.56645455
91glutamine family amino acid biosynthetic process (GO:0009084)3.56227517
92serine family amino acid metabolic process (GO:0009069)3.55709121
93regulation of cholesterol metabolic process (GO:0090181)3.54024072
94ethanol metabolic process (GO:0006067)3.53581660
95glucose 6-phosphate metabolic process (GO:0051156)3.52021388
96monocarboxylic acid catabolic process (GO:0072329)3.51585393
97pentose-phosphate shunt (GO:0006098)3.50772309
98NADPH regeneration (GO:0006740)3.50457999
99branched-chain amino acid metabolic process (GO:0009081)3.50337913
100* thioester metabolic process (GO:0035383)3.50206807
101* acyl-CoA metabolic process (GO:0006637)3.50206807
102peptidyl-arginine omega-N-methylation (GO:0035247)3.48024898
103regulation of sequestering of triglyceride (GO:0010889)3.47398713
104regulation of triglyceride metabolic process (GO:0090207)3.45996666
105cellular modified amino acid catabolic process (GO:0042219)3.45602241
106organic acid catabolic process (GO:0016054)3.44022409
107carboxylic acid catabolic process (GO:0046395)3.44022409
108pentose metabolic process (GO:0019321)3.43595270
109regulation of cholesterol biosynthetic process (GO:0045540)3.42180633
110serine family amino acid biosynthetic process (GO:0009070)3.41368095
111tricarboxylic acid metabolic process (GO:0072350)3.40264399
112very long-chain fatty acid metabolic process (GO:0000038)3.40019516
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34100121
114phospholipid efflux (GO:0033700)3.33218128
115heme transport (GO:0015886)3.33056373
1162-oxoglutarate metabolic process (GO:0006103)3.32385929
117NADP metabolic process (GO:0006739)3.32158802
118regulation of mammary gland epithelial cell proliferation (GO:0033599)3.28529505
119glucose catabolic process (GO:0006007)3.26817028
120oxaloacetate metabolic process (GO:0006107)3.26428802
121negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19208836
122nuclear envelope reassembly (GO:0031468)3.18836239
123mitotic nuclear envelope reassembly (GO:0007084)3.18836239
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.14662393
125* monosaccharide biosynthetic process (GO:0046364)3.08991311
126cholesterol biosynthetic process (GO:0006695)3.08587316
1274-hydroxyproline metabolic process (GO:0019471)3.04597795
128* gluconeogenesis (GO:0006094)3.04385769
129histone arginine methylation (GO:0034969)2.98104369
130nucleobase-containing small molecule interconversion (GO:0015949)2.91277858
131* hexose biosynthetic process (GO:0019319)2.90250599
132folic acid metabolic process (GO:0046655)2.82789838
133DNA unwinding involved in DNA replication (GO:0006268)2.82641939
134formation of translation preinitiation complex (GO:0001731)2.79211414
135amyloid precursor protein catabolic process (GO:0042987)2.75222355
136peptidyl-arginine N-methylation (GO:0035246)2.72219693
137peptidyl-arginine methylation (GO:0018216)2.72219693
138ribosomal small subunit biogenesis (GO:0042274)2.71877566
139sterol biosynthetic process (GO:0016126)2.63993251
140fatty acid homeostasis (GO:0055089)2.63435730
141L-serine transport (GO:0015825)2.63391534
142DNA strand elongation involved in DNA replication (GO:0006271)2.62692274
143oxidative phosphorylation (GO:0006119)2.60546203
144heterochromatin organization (GO:0070828)2.60085627
145DNA replication initiation (GO:0006270)2.57270881
146DNA strand elongation (GO:0022616)2.55063406
147very-low-density lipoprotein particle assembly (GO:0034379)2.53809073
148regulation of mitochondrial translation (GO:0070129)2.52848736
149DNA strand renaturation (GO:0000733)2.50784146
150guanosine-containing compound biosynthetic process (GO:1901070)2.47457828
151tricarboxylic acid cycle (GO:0006099)2.46493670
152diacylglycerol metabolic process (GO:0046339)2.45270822
153negative regulation of cell size (GO:0045792)2.43970687
154pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.39202861
155telomere maintenance via semi-conservative replication (GO:0032201)2.38279210
156glycolytic process (GO:0006096)2.36764233
157serine transport (GO:0032329)2.36753678
158pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.36375487
159nucleotide-sugar biosynthetic process (GO:0009226)2.35796803
160coenzyme A biosynthetic process (GO:0015937)2.35364613
161positive regulation of cellular amine metabolic process (GO:0033240)2.34509303
162midgut development (GO:0007494)2.33589268
163negative regulation of fatty acid biosynthetic process (GO:0045717)2.32220889
164apoptotic process involved in morphogenesis (GO:0060561)2.31633241
165DNA replication checkpoint (GO:0000076)2.31113374
166rRNA transcription (GO:0009303)2.30082234
167plasma lipoprotein particle assembly (GO:0034377)2.29273650
168pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.26680189
169purine ribonucleotide transport (GO:0015868)2.25302734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.98967304
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.03422705
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.49246221
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.68585933
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.82052307
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.51024083
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.04537444
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.88807138
9E2F7_22180533_ChIP-Seq_HELA_Human3.44518110
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.32292124
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.09953169
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95044177
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.70440020
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67107621
15CLOCK_20551151_ChIP-Seq_293T_Human2.65486071
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.50108299
17* XRN2_22483619_ChIP-Seq_HELA_Human2.05276746
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03992700
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.03067363
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93525633
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86107751
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.84039566
23ZNF263_19887448_ChIP-Seq_K562_Human1.80717792
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79412317
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76153199
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75330789
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74830627
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72715882
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68261187
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66532472
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65208470
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64521600
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57862186
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.56964962
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53902328
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52982875
37MYC_22102868_ChIP-Seq_BL_Human1.52092826
38DCP1A_22483619_ChIP-Seq_HELA_Human1.49138411
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48805486
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.46293344
41GABP_19822575_ChIP-Seq_HepG2_Human1.46271426
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42864073
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.40223037
44* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35263478
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34062720
46* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33731695
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30980190
48* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28815460
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28391683
50* LXR_22292898_ChIP-Seq_THP-1_Human1.28228701
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26572734
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24486989
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23232836
54* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22590896
55* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19691186
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19044567
57FOXP1_21924763_ChIP-Seq_HESCs_Human1.18727750
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18374252
59* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17610413
60* NCOR1_26117541_ChIP-Seq_K562_Human1.16766720
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15526357
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.15208551
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14643004
64SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14516379
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14007828
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12788042
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12003893
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.11788399
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11639001
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11517317
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10803948
72TTF2_22483619_ChIP-Seq_HELA_Human1.10491576
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10408684
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09607286
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08937691
76SMC4_20622854_ChIP-Seq_HELA_Human1.08105055
77* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08080454
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07117880
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06415250
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05907894
81* KDM5A_27292631_Chip-Seq_BREAST_Human1.05752457
82AR_21909140_ChIP-Seq_LNCAP_Human1.05090353
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03485051
84* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03209479
85TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02868474
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.01078408
87GATA4_25053715_ChIP-Seq_YYC3_Human1.01002439
88HNF4A_19822575_ChIP-Seq_HepG2_Human1.00869680
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.00851476
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00220867
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99617195
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98981278
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.97364872
94GATA1_22025678_ChIP-Seq_K562_Human0.96118990
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87864790
96* ELK3_25401928_ChIP-Seq_HUVEC_Human0.86607336
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85426346
98IRF8_22096565_ChIP-ChIP_GC-B_Human0.85376660
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84026046
100* RARB_24833708_ChIP-Seq_LIVER_Mouse0.83633994
101BCOR_27268052_Chip-Seq_Bcells_Human0.83535308
102TET1_21451524_ChIP-Seq_MESCs_Mouse0.83228123
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82423331
104ATF3_27146783_Chip-Seq_COLON_Human0.82378665
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81659228
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.80572363
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78768311
108BCL6_27268052_Chip-Seq_Bcells_Human0.78700436
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78112239
110* VDR_21846776_ChIP-Seq_THP-1_Human0.77995348
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75764050
112GATA6_25053715_ChIP-Seq_YYC3_Human0.74779005
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73563889
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72758814
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72314340
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72283138
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72213999
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71358047
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71334556
120P68_20966046_ChIP-Seq_HELA_Human0.71283822
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.71197675
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.70802649
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.70544525
124ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70153660
125* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70085020
126* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69797398
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69188422
128HTT_18923047_ChIP-ChIP_STHdh_Human0.68154621
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.68148614
130* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.67695092
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.66764922
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66518226
133* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.66209518
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.66119839
135GATA1_19941826_ChIP-Seq_K562_Human0.65594268
136* CTCF_21964334_Chip-Seq_Bcells_Human0.64914022
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.64286847
138P300_27268052_Chip-Seq_Bcells_Human0.64007990
139TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63773619
140SA1_27219007_Chip-Seq_ERYTHROID_Human0.62196434
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.61315049
142* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.61112544
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.61102140
144* FOXO3_23340844_ChIP-Seq_DLD1_Human0.61060364
145CTCF_21964334_ChIP-Seq_BJAB-B_Human0.59952658
146* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.59792190
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.59226437
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.59062513
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58718184
150CREB1_26743006_Chip-Seq_LNCaP_Human0.58323385
151* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.57840984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.21124464
2MP0005360_urolithiasis6.37445153
3MP0005365_abnormal_bile_salt5.24544344
4MP0005085_abnormal_gallbladder_physiolo5.02331916
5MP0003806_abnormal_nucleotide_metabolis4.15327511
6MP0008875_abnormal_xenobiotic_pharmacok3.97230133
7MP0010329_abnormal_lipoprotein_level3.61588016
8MP0009840_abnormal_foam_cell3.27310262
9MP0005083_abnormal_biliary_tract3.10390293
10MP0003252_abnormal_bile_duct2.91937542
11MP0000678_abnormal_parathyroid_gland2.74240783
12MP0005670_abnormal_white_adipose2.62331854
13MP0005332_abnormal_amino_acid2.60381306
14MP0001666_abnormal_nutrient_absorption2.51373264
15MP0003191_abnormal_cellular_cholesterol2.49682681
16MP0002118_abnormal_lipid_homeostasis2.45975571
17MP0010030_abnormal_orbit_morphology2.43937023
18MP0002249_abnormal_larynx_morphology2.34521081
19MP0003195_calcinosis2.26188693
20MP0000609_abnormal_liver_physiology2.23723253
21MP0003111_abnormal_nucleus_morphology2.18612398
22MP0003693_abnormal_embryo_hatching2.16575375
23MP0008932_abnormal_embryonic_tissue2.01764893
24MP0005666_abnormal_adipose_tissue1.97177013
25MP0004957_abnormal_blastocyst_morpholog1.96687943
26MP0004858_abnormal_nervous_system1.93721578
27MP0003186_abnormal_redox_activity1.93132597
28MP0004019_abnormal_vitamin_homeostasis1.91759802
29MP0004130_abnormal_muscle_cell1.83230763
30MP0005319_abnormal_enzyme/_coenzyme1.81471435
31MP0005584_abnormal_enzyme/coenzyme_acti1.79881395
32MP0003705_abnormal_hypodermis_morpholog1.75000996
33MP0004272_abnormal_basement_membrane1.73661271
34MP0004185_abnormal_adipocyte_glucose1.70397465
35MP0000537_abnormal_urethra_morphology1.69115607
36MP0000566_synostosis1.61896067
37MP0001881_abnormal_mammary_gland1.55675264
38MP0001849_ear_inflammation1.55119607
39MP0009643_abnormal_urine_homeostasis1.55090915
40MP0003868_abnormal_feces_composition1.50553766
41MP0001764_abnormal_homeostasis1.49792996
42MP0008438_abnormal_cutaneous_collagen1.49191741
43MP0003011_delayed_dark_adaptation1.45726347
44MP0008260_abnormal_autophagy1.44445855
45MP0003656_abnormal_erythrocyte_physiolo1.41079536
46MP0001730_embryonic_growth_arrest1.38952323
47MP0004233_abnormal_muscle_weight1.37558830
48MP0002877_abnormal_melanocyte_morpholog1.34841288
49MP0003077_abnormal_cell_cycle1.34532269
50MP0005076_abnormal_cell_differentiation1.34322104
51MP0002971_abnormal_brown_adipose1.34130606
52MP0003942_abnormal_urinary_system1.32961896
53MP0005375_adipose_tissue_phenotype1.31130236
54MP0005334_abnormal_fat_pad1.28760962
55MP0005257_abnormal_intraocular_pressure1.26459919
56MP0000598_abnormal_liver_morphology1.23461687
57MP0002138_abnormal_hepatobiliary_system1.22540709
58MP0003123_paternal_imprinting1.20241065
59MP0002234_abnormal_pharynx_morphology1.16665732
60MP0006036_abnormal_mitochondrial_physio1.15357047
61MP0003453_abnormal_keratinocyte_physiol1.13419013
62MP0005623_abnormal_meninges_morphology1.13380715
63MP0001661_extended_life_span1.13204096
64MP0002078_abnormal_glucose_homeostasis1.11168747
65MP0000462_abnormal_digestive_system1.09950223
66MP0003315_abnormal_perineum_morphology1.09541089
67MP0002970_abnormal_white_adipose1.09182744
68MP0000604_amyloidosis1.07004554
69MP0004782_abnormal_surfactant_physiolog1.05593992
70MP0002080_prenatal_lethality1.05588353
71MP0008007_abnormal_cellular_replicative1.04876312
72MP0005636_abnormal_mineral_homeostasis1.04137231
73MP0000467_abnormal_esophagus_morphology1.02958532
74MP0010094_abnormal_chromosome_stability1.01770513
75MP0003959_abnormal_lean_body0.99638072
76MP0003786_premature_aging0.99315580
77MP0000350_abnormal_cell_proliferation0.98206368
78MP0005380_embryogenesis_phenotype0.97981177
79MP0001672_abnormal_embryogenesis/_devel0.97981177
80MP0002254_reproductive_system_inflammat0.96207231
81MP0000681_abnormal_thyroid_gland0.95156082
82MP0005058_abnormal_lysosome_morphology0.94232805
83MP0002876_abnormal_thyroid_physiology0.94029979
84MP0005448_abnormal_energy_balance0.93827080
85MP0001756_abnormal_urination0.92872241
86MP0002796_impaired_skin_barrier0.91905224
87MP0001727_abnormal_embryo_implantation0.91692650
88MP0009763_increased_sensitivity_to0.91602407
89MP0003329_amyloid_beta_deposits0.91422938
90MP0005535_abnormal_body_temperature0.90575244
91MP0003984_embryonic_growth_retardation0.89742404
92MP0000049_abnormal_middle_ear0.89113671
93MP0009642_abnormal_blood_homeostasis0.88951556
94MP0005220_abnormal_exocrine_pancreas0.88785097
95MP0002111_abnormal_tail_morphology0.87355988
96MP0009115_abnormal_fat_cell0.87241135
97MP0002085_abnormal_embryonic_tissue0.87218155
98MP0003941_abnormal_skin_development0.87066829
99MP0000538_abnormal_urinary_bladder0.86326305
100MP0005647_abnormal_sex_gland0.84511276
101MP0002088_abnormal_embryonic_growth/wei0.83964990
102MP0002089_abnormal_postnatal_growth/wei0.82781819
103MP0008469_abnormal_protein_level0.82628515
104MP0001697_abnormal_embryo_size0.82610811
105MP0000358_abnormal_cell_content/0.81342923
106MP0005451_abnormal_body_composition0.81174162
107MP0005376_homeostasis/metabolism_phenot0.79120832
108MP0010352_gastrointestinal_tract_polyps0.78945316
109MP0005275_abnormal_skin_tensile0.78930291
110MP0002098_abnormal_vibrissa_morphology0.77709851
111MP0000534_abnormal_ureter_morphology0.77702201
112MP0003724_increased_susceptibility_to0.76716695
113MP0000490_abnormal_crypts_of0.76572173
114MP0002132_abnormal_respiratory_system0.76362363
115MP0001346_abnormal_lacrimal_gland0.75634788
116MP0001216_abnormal_epidermal_layer0.75526708
117MP0005266_abnormal_metabolism0.75377130
118MP0002697_abnormal_eye_size0.74459456
119MP0003300_gastrointestinal_ulcer0.74133973
120MP0000858_altered_metastatic_potential0.73824110
121MP0002086_abnormal_extraembryonic_tissu0.72934734
122MP0000003_abnormal_adipose_tissue0.72575376
123MP0003385_abnormal_body_wall0.71913188
124MP0003690_abnormal_glial_cell0.70581920
125MP0000639_abnormal_adrenal_gland0.69825844
126MP0004264_abnormal_extraembryonic_tissu0.66216702
127MP0003953_abnormal_hormone_level0.63941998
128MP0009765_abnormal_xenobiotic_induced0.62705424
129MP0009764_decreased_sensitivity_to0.61815033
130MP0000013_abnormal_adipose_tissue0.61676669
131MP0005452_abnormal_adipose_tissue0.60293913
132MP0005408_hypopigmentation0.59469083
133MP0004043_abnormal_pH_regulation0.57817478
134MP0010234_abnormal_vibrissa_follicle0.56996174
135MP0002136_abnormal_kidney_physiology0.56362160
136MP0005084_abnormal_gallbladder_morpholo0.55944142
137MP0002060_abnormal_skin_morphology0.54141177
138MP0003436_decreased_susceptibility_to0.52403524
139MP0004147_increased_porphyrin_level0.51614925
140MP0002837_dystrophic_cardiac_calcinosis0.51061146
141MP0005464_abnormal_platelet_physiology0.50513437
142MP0008873_increased_physiological_sensi0.48708335
143MP0001243_abnormal_dermal_layer0.48382857
144MP0003638_abnormal_response/metabolism_0.48286634
145MP0001944_abnormal_pancreas_morphology0.46996624
146MP0005501_abnormal_skin_physiology0.46987447
147MP0006035_abnormal_mitochondrial_morpho0.44614804
148MP0009672_abnormal_birth_weight0.43525291
149MP0005395_other_phenotype0.43382772
150MP0009697_abnormal_copulation0.41659671
151MP0005164_abnormal_response_to0.40563731
152MP0005023_abnormal_wound_healing0.39295972
153MP0002909_abnormal_adrenal_gland0.39022014
154MP0008872_abnormal_physiological_respon0.38749573
155MP0002168_other_aberrant_phenotype0.37870863
156MP0000249_abnormal_blood_vessel0.36593217
157MP0003566_abnormal_cell_adhesion0.35302625
158MP0008961_abnormal_basal_metabolism0.35241614

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.53196815
2Intrahepatic cholestasis (HP:0001406)5.67372029
3Xanthomatosis (HP:0000991)5.61989348
4Deep venous thrombosis (HP:0002625)5.53922657
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.19405140
6Hypobetalipoproteinemia (HP:0003563)4.76542262
7Hyperlipoproteinemia (HP:0010980)4.63167316
8Complement deficiency (HP:0004431)4.45843999
9Hyperammonemia (HP:0001987)4.41605038
10Abnormality of serine family amino acid metabolism (HP:0010894)4.33599986
11Abnormality of glycine metabolism (HP:0010895)4.33599986
12Hyperglycinuria (HP:0003108)4.33090347
13Ketosis (HP:0001946)4.31724945
14Prolonged partial thromboplastin time (HP:0003645)4.29401296
15Hyperglycinemia (HP:0002154)4.15984623
16Epidermoid cyst (HP:0200040)4.14580548
17Hypoglycemic coma (HP:0001325)3.99390838
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.94347389
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.76492121
20Hypolipoproteinemia (HP:0010981)3.71892649
21Abnormality of fatty-acid metabolism (HP:0004359)3.65349600
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.59044687
23Truncus arteriosus (HP:0001660)3.46228152
24Abnormality of the common coagulation pathway (HP:0010990)3.42492841
25Ketoacidosis (HP:0001993)3.42351065
26Hypoalphalipoproteinemia (HP:0003233)3.35004390
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.34977279
28Hyperthyroidism (HP:0000836)3.33200429
29Abnormality of complement system (HP:0005339)3.28121736
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25683786
31Fat malabsorption (HP:0002630)3.22367723
32Abnormality of the intrinsic pathway (HP:0010989)3.20239901
33Hypercholesterolemia (HP:0003124)3.15365387
34Abnormality of methionine metabolism (HP:0010901)3.05875956
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.05351939
36Dicarboxylic aciduria (HP:0003215)3.05351939
37Joint hemorrhage (HP:0005261)2.93141383
38Premature rupture of membranes (HP:0001788)2.91333808
39Abnormality of purine metabolism (HP:0004352)2.90143135
40Vertebral compression fractures (HP:0002953)2.89993656
41Delayed CNS myelination (HP:0002188)2.87041245
42Abnormality of nucleobase metabolism (HP:0010932)2.81584663
43Hyperbilirubinemia (HP:0002904)2.79265370
44Skin nodule (HP:0200036)2.77184080
45Abnormality of serum amino acid levels (HP:0003112)2.75508447
46Lethargy (HP:0001254)2.64652828
47Abnormality of pyrimidine metabolism (HP:0004353)2.64467720
48Ulnar bowing (HP:0003031)2.64211886
49Abnormality of proline metabolism (HP:0010907)2.60831743
50Hydroxyprolinuria (HP:0003080)2.60831743
51Metabolic acidosis (HP:0001942)2.60806360
52Hypertriglyceridemia (HP:0002155)2.60002248
53Achilles tendon contracture (HP:0001771)2.57409172
54Abnormal cartilage morphology (HP:0002763)2.56974579
55Brushfield spots (HP:0001088)2.54346486
56Seborrheic dermatitis (HP:0001051)2.53696511
57Hypoglycemic seizures (HP:0002173)2.47861499
58Steatorrhea (HP:0002570)2.44938195
59Conjugated hyperbilirubinemia (HP:0002908)2.44500558
60Myocardial infarction (HP:0001658)2.44443589
61Reticulocytosis (HP:0001923)2.42376921
62Spastic diplegia (HP:0001264)2.42213649
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41868933
64Septate vagina (HP:0001153)2.41424989
65Gout (HP:0001997)2.40311033
66Abnormal gallbladder physiology (HP:0012438)2.38955339
67Cholecystitis (HP:0001082)2.38955339
68Abnormality of glycolysis (HP:0004366)2.38338082
69Increased serum pyruvate (HP:0003542)2.38338082
70Generalized aminoaciduria (HP:0002909)2.37706712
71Pancreatitis (HP:0001733)2.35960839
72Late onset (HP:0003584)2.35356207
73Atelectasis (HP:0100750)2.31830538
74Testicular atrophy (HP:0000029)2.29844619
75Neonatal onset (HP:0003623)2.28658383
76* Irritability (HP:0000737)2.24674052
77Opisthotonus (HP:0002179)2.24601845
78Hepatocellular carcinoma (HP:0001402)2.23588139
79Cerebral edema (HP:0002181)2.23231700
80Distal upper limb amyotrophy (HP:0007149)2.22253131
81Upper limb amyotrophy (HP:0009129)2.22253131
82Protrusio acetabuli (HP:0003179)2.19567131
83Vomiting (HP:0002013)2.19480880
84Abnormality of transition element cation homeostasis (HP:0011030)2.18474834
85Hyperacusis (HP:0010780)2.17375512
86Abnormal gallbladder morphology (HP:0012437)2.16837301
87Ragged-red muscle fibers (HP:0003200)2.16618109
88Hypertensive crisis (HP:0100735)2.16616722
89Abnormality of iron homeostasis (HP:0011031)2.15830369
90Abnormality of reticulocytes (HP:0004312)2.15187304
91Biconcave vertebral bodies (HP:0004586)2.15148543
92Abnormality of the tricuspid valve (HP:0001702)2.14716601
93Increased serum ferritin (HP:0003281)2.13767490
94Increased muscle lipid content (HP:0009058)2.10697151
95Hemorrhage of the eye (HP:0011885)2.09576612
96Oligomenorrhea (HP:0000876)2.09222857
97Breast hypoplasia (HP:0003187)2.08884212
98Nonimmune hydrops fetalis (HP:0001790)2.08388480
99Systemic lupus erythematosus (HP:0002725)2.08121635
100Malnutrition (HP:0004395)2.07679630
101Acanthocytosis (HP:0001927)2.05668177
102Ileus (HP:0002595)2.05004627
103Hyperinsulinemic hypoglycemia (HP:0000825)2.04534278
104Amyloidosis (HP:0011034)2.04261459
105Abnormality of the umbilical cord (HP:0010881)2.03826277
106Myoglobinuria (HP:0002913)2.03614250
107Cholelithiasis (HP:0001081)2.03245792
108Broad distal phalanx of finger (HP:0009836)2.01069663
109Breech presentation (HP:0001623)2.00175791
110Turricephaly (HP:0000262)1.99417241
111Patellar dislocation (HP:0002999)1.99247813
112Hypokinesia (HP:0002375)1.98437636
113Trismus (HP:0000211)1.97825089
114Hypoparathyroidism (HP:0000829)1.97628556
115Vaginal fistula (HP:0004320)1.97141473
116Epiphyseal stippling (HP:0010655)1.95202690
117Acanthosis nigricans (HP:0000956)1.94775479
118Abnormal enzyme/coenzyme activity (HP:0012379)1.91627309
119Microvesicular hepatic steatosis (HP:0001414)1.91408176
120Double outlet right ventricle (HP:0001719)1.91294680
121Congenital malformation of the right heart (HP:0011723)1.91294680
122Insulin resistance (HP:0000855)1.91096739
123Long palpebral fissure (HP:0000637)1.90443247
124Spontaneous abortion (HP:0005268)1.89972810
125Nausea (HP:0002018)1.85556842
126Rhabdomyolysis (HP:0003201)1.85015864
127Abnormally folded helix (HP:0008544)1.84835551
128Abnormality of the fetal cardiovascular system (HP:0010948)1.84098311
129Abnormal umbilical cord blood vessels (HP:0011403)1.84098311
130Single umbilical artery (HP:0001195)1.84098311
131Sensorimotor neuropathy (HP:0007141)1.82739715
132Disproportionate tall stature (HP:0001519)1.82723379
133Microretrognathia (HP:0000308)1.82353672
134Multiple enchondromatosis (HP:0005701)1.82277057
135Abnormality of the gallbladder (HP:0005264)1.81509263
136Hand muscle atrophy (HP:0009130)1.79613709
137Elevated hepatic transaminases (HP:0002910)1.79444448
138Hepatic necrosis (HP:0002605)1.79290515
139Premature skin wrinkling (HP:0100678)1.78098521
140Symptomatic seizures (HP:0011145)1.77199591
141Abnormality of carpal bone ossification (HP:0006257)1.77021253
142Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76487342
143Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76487342
144Rough bone trabeculation (HP:0100670)1.76453233
145Methylmalonic aciduria (HP:0012120)1.75927190
146Vascular calcification (HP:0004934)1.75616750
147Entropion (HP:0000621)1.75228522
148Poikiloderma (HP:0001029)1.75219433
149Abnormal hemoglobin (HP:0011902)1.74906275
150Abnormality of the Achilles tendon (HP:0005109)1.74628727
151Abnormal tarsal ossification (HP:0008369)1.73549223
152Abnormality of the distal phalanges of the toes (HP:0010182)1.73120787
153Abnormal large intestine physiology (HP:0012700)1.72811402
154Hypoplastic left heart (HP:0004383)1.71515388
155Unilateral renal agenesis (HP:0000122)1.70952285
156Progressive muscle weakness (HP:0003323)1.70013261
157Myopathic facies (HP:0002058)1.69809191
158Prolonged neonatal jaundice (HP:0006579)1.69578053
159Bowel incontinence (HP:0002607)1.69189797
160Elbow flexion contracture (HP:0002987)1.68916287
161Abnormalities of placenta or umbilical cord (HP:0001194)1.68838594
162Overlapping toe (HP:0001845)1.68462119
163Cervical subluxation (HP:0003308)1.67662992
164Back pain (HP:0003418)1.67456734
165Gastrointestinal dysmotility (HP:0002579)1.65572594
166Selective tooth agenesis (HP:0001592)1.64873077
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62294173
168Overfolded helix (HP:0000396)1.60918535
169Abnormality of the aortic arch (HP:0012303)1.60612856
170Abdominal distention (HP:0003270)1.60329759
171Thin bony cortex (HP:0002753)1.60029821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.02860731
2ERN15.10712767
3SIK14.54194108
4TRIB34.10626070
5SMG14.05659365
6CAMK1D3.45088396
7PKN22.94043550
8IRAK32.87166266
9FLT32.60925987
10FGFR42.44546392
11VRK22.36250298
12BUB12.30386303
13CAMK1G2.12541694
14EEF2K1.79537189
15MET1.73953673
16MST1R1.72409045
17EPHB11.66138195
18PRKD31.57814777
19ARAF1.39944693
20TAOK31.37978686
21TESK21.37343609
22MAPKAPK31.36918583
23STK161.35236783
24NME21.35218862
25INSRR1.30810241
26PTK61.27941789
27MAP3K101.26891979
28ERBB41.24464761
29MAPK111.23036193
30TTK1.21990210
31CDK71.20864944
32EIF2AK11.16162514
33MAP3K111.14240862
34PDK31.12137721
35PDK41.12137721
36RIPK11.10019495
37MAP2K21.09490459
38BRAF1.08340756
39LRRK21.07207988
40AURKA1.06510362
41NTRK11.05351651
42ABL21.05244849
43CDK81.05078164
44NME11.00216850
45KDR0.98164783
46NEK10.97919681
47TAOK20.97043213
48PRKAA20.97000835
49MAP2K30.96571148
50BRSK10.96509392
51CHEK20.96116293
52TBK10.94148045
53SCYL20.93349030
54ICK0.93135344
55DAPK10.91120452
56IRAK20.89215836
57PRPF4B0.86595432
58PTK20.86129469
59TAF10.85777464
60RET0.82511322
61EPHB20.80657917
62PDGFRA0.79680514
63MAP2K10.79474541
64JAK20.78478254
65MAPK150.74695050
66WNK40.74069532
67AKT20.74051845
68TYK20.73048120
69MTOR0.72342668
70CSNK1A1L0.70767661
71GSK3A0.69623685
72PIK3CG0.69557631
73DYRK1B0.69245079
74MATK0.68000222
75ZAP700.66627724
76PAK10.66393522
77TESK10.66223331
78CDK60.66157487
79PRKCI0.65632854
80KSR20.65499861
81GRK60.65437906
82FGFR20.63016019
83CDC70.62864288
84CLK10.62534430
85BMX0.61626767
86STK40.59902667
87PAK20.59156991
88CSF1R0.58565306
89SRPK10.57635868
90CDK40.57612275
91CDK11A0.57053370
92MAPK40.56811051
93MAP2K40.56710869
94RPS6KB20.56684718
95PRKG20.55358050
96LIMK10.55075980
97CDK90.55037627
98AURKB0.54899580
99STK390.54825128
100CDK150.53686368
101DDR20.53593864
102MAP3K70.52799285
103PAK40.51844431
104PRKACG0.51227431
105CDK120.51065935
106PLK10.51029154
107CHEK10.50273734
108PDPK10.50131589
109CDK180.50028485
110MAP3K20.49825839
111MAP3K30.48779711
112JAK30.48729898
113CSNK1G20.48481942
114DYRK20.48357632
115ATR0.48168234
116CDK140.47402000
117NEK20.46512120
118PRKAA10.46430764
119PIM20.45574136
120MAP2K60.43692161
121EPHA20.42464059
122TGFBR20.41197196
123ERBB20.41154338
124MAPKAPK50.39896069
125PRKCZ0.39860695
126DYRK30.39799678
127PASK0.38849161
128CSK0.38689610
129ILK0.38196320
130TGFBR10.38059464
131MAP3K10.37121545
132CSNK1G30.36912126
133LATS10.36778444
134CSNK1G10.36319726
135RPS6KA20.36291822
136MAP3K80.34794661
137PBK0.34694859
138PRKD20.34636040
139RPS6KA40.32946257
140LATS20.31585393
141EPHA30.31532963
142FGFR10.30763097
143ACVR1B0.29631033
144LMTK20.29593297
145DAPK30.29561756
146IGF1R0.29040930
147PDK20.28988538

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.42267304
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93578379
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.91576547
4Nitrogen metabolism_Homo sapiens_hsa009102.82827177
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79065130
6Fatty acid degradation_Homo sapiens_hsa000712.72995350
7Propanoate metabolism_Homo sapiens_hsa006402.65146033
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60905047
9Fatty acid metabolism_Homo sapiens_hsa012122.53048546
10Tryptophan metabolism_Homo sapiens_hsa003802.40656505
11Arginine biosynthesis_Homo sapiens_hsa002202.34836779
12PPAR signaling pathway_Homo sapiens_hsa033202.30017926
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25483228
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18562998
15Butanoate metabolism_Homo sapiens_hsa006502.18216393
16Caffeine metabolism_Homo sapiens_hsa002322.13359046
17Peroxisome_Homo sapiens_hsa041462.07458437
18Pyruvate metabolism_Homo sapiens_hsa006202.05532925
19Fatty acid biosynthesis_Homo sapiens_hsa000612.04667735
20DNA replication_Homo sapiens_hsa030302.00078343
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96838898
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94709990
23Complement and coagulation cascades_Homo sapiens_hsa046101.90117932
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89211159
25Fatty acid elongation_Homo sapiens_hsa000621.85625567
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84522398
27Steroid biosynthesis_Homo sapiens_hsa001001.79909181
28Histidine metabolism_Homo sapiens_hsa003401.71901217
29Base excision repair_Homo sapiens_hsa034101.70456923
30beta-Alanine metabolism_Homo sapiens_hsa004101.68645202
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63965155
32Chemical carcinogenesis_Homo sapiens_hsa052041.63745351
33Fat digestion and absorption_Homo sapiens_hsa049751.62847089
34Sulfur metabolism_Homo sapiens_hsa009201.61101899
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.55373777
36Folate biosynthesis_Homo sapiens_hsa007901.54094404
37Carbon metabolism_Homo sapiens_hsa012001.52750630
38Phenylalanine metabolism_Homo sapiens_hsa003601.47598285
39Tyrosine metabolism_Homo sapiens_hsa003501.46074771
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44147222
41Selenocompound metabolism_Homo sapiens_hsa004501.42522481
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42439673
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40241318
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.38433041
45Biosynthesis of amino acids_Homo sapiens_hsa012301.35885457
46Other glycan degradation_Homo sapiens_hsa005111.32316990
47Sulfur relay system_Homo sapiens_hsa041221.26324970
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25287765
49Retinol metabolism_Homo sapiens_hsa008301.24371009
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.18530715
51Mismatch repair_Homo sapiens_hsa034301.17928794
52Proteasome_Homo sapiens_hsa030501.16870428
53Glycerolipid metabolism_Homo sapiens_hsa005611.16247624
54Bile secretion_Homo sapiens_hsa049761.15064509
55Staphylococcus aureus infection_Homo sapiens_hsa051501.12886051
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.12784625
57Pentose phosphate pathway_Homo sapiens_hsa000301.10877800
58Starch and sucrose metabolism_Homo sapiens_hsa005001.07885134
59Pyrimidine metabolism_Homo sapiens_hsa002401.05731017
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00216822
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96855095
62Arginine and proline metabolism_Homo sapiens_hsa003300.94037679
63Glutathione metabolism_Homo sapiens_hsa004800.91146507
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.90539237
65ABC transporters_Homo sapiens_hsa020100.89428425
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87524987
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80447708
68Vitamin B6 metabolism_Homo sapiens_hsa007500.72061723
69Vitamin digestion and absorption_Homo sapiens_hsa049770.70711274
70Vibrio cholerae infection_Homo sapiens_hsa051100.67877611
71Galactose metabolism_Homo sapiens_hsa000520.67007109
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63205798
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62071884
74Lysine degradation_Homo sapiens_hsa003100.60764784
75One carbon pool by folate_Homo sapiens_hsa006700.60565666
76Cell cycle_Homo sapiens_hsa041100.60256947
77Spliceosome_Homo sapiens_hsa030400.57810877
78Nucleotide excision repair_Homo sapiens_hsa034200.57007011
79Metabolic pathways_Homo sapiens_hsa011000.56366790
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.52217233
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52183129
82Fructose and mannose metabolism_Homo sapiens_hsa000510.51368525
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45748726
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44597407
85RNA polymerase_Homo sapiens_hsa030200.43493844
86RNA transport_Homo sapiens_hsa030130.42490025
87AMPK signaling pathway_Homo sapiens_hsa041520.40792172
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40429962
89Sphingolipid metabolism_Homo sapiens_hsa006000.40088946
90Chronic myeloid leukemia_Homo sapiens_hsa052200.38842952
91Linoleic acid metabolism_Homo sapiens_hsa005910.37299122
92Notch signaling pathway_Homo sapiens_hsa043300.35749287
93Insulin resistance_Homo sapiens_hsa049310.35138397
94Huntingtons disease_Homo sapiens_hsa050160.33006982
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32551158
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30746507
97Basal cell carcinoma_Homo sapiens_hsa052170.30720082
98Purine metabolism_Homo sapiens_hsa002300.29867207
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28483677
100Homologous recombination_Homo sapiens_hsa034400.28434569
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.27707763
102Prion diseases_Homo sapiens_hsa050200.27202318
103Acute myeloid leukemia_Homo sapiens_hsa052210.26407153
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24026951
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24006789
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.14503781
107Protein export_Homo sapiens_hsa030600.13541954
108Insulin signaling pathway_Homo sapiens_hsa049100.12278968
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11636438
110N-Glycan biosynthesis_Homo sapiens_hsa005100.10575039
111Glucagon signaling pathway_Homo sapiens_hsa049220.08567913
112Renin-angiotensin system_Homo sapiens_hsa046140.07649250
113Lysosome_Homo sapiens_hsa041420.04062745
114Bladder cancer_Homo sapiens_hsa052190.01060977
115Ribosome_Homo sapiens_hsa03010-0.1500177
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1498316
117Oxidative phosphorylation_Homo sapiens_hsa00190-0.1363112
118Hepatitis C_Homo sapiens_hsa05160-0.1269579
119Parkinsons disease_Homo sapiens_hsa05012-0.1234333
120Thyroid cancer_Homo sapiens_hsa05216-0.1192175
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.1032323
122Protein digestion and absorption_Homo sapiens_hsa04974-0.0339946
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0321210
124Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0218312

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