SLC24A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01717576
2negative regulation of cell killing (GO:0031342)5.01717576
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.00698165
4vocalization behavior (GO:0071625)4.98079748
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95364476
6positive regulation of gamma-delta T cell activation (GO:0046645)4.85361235
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.78288888
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.74502687
9neuron cell-cell adhesion (GO:0007158)4.67423627
10regulation of B cell receptor signaling pathway (GO:0050855)4.58286529
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.55462927
12glutamate receptor signaling pathway (GO:0007215)4.40907041
13protein localization to synapse (GO:0035418)4.40059630
14activated T cell proliferation (GO:0050798)4.39202525
15regulation of glutamate receptor signaling pathway (GO:1900449)4.38215535
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.32196691
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.32196691
18modulation by symbiont of host immune response (GO:0052553)4.32196691
19positive regulation by symbiont of host defense response (GO:0052509)4.32196691
20modulation by symbiont of host defense response (GO:0052031)4.32196691
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.32196691
22neurotransmitter-gated ion channel clustering (GO:0072578)4.23935316
23locomotory exploration behavior (GO:0035641)4.19276402
24antigen processing and presentation of endogenous antigen (GO:0019883)4.19108840
25microglial cell activation (GO:0001774)4.13123869
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.11444587
27neutrophil activation involved in immune response (GO:0002283)4.10670832
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03982319
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.03981304
30synaptic transmission, glutamatergic (GO:0035249)4.01448228
31neuron-neuron synaptic transmission (GO:0007270)3.97882756
32synaptic vesicle exocytosis (GO:0016079)3.97597807
33positive regulation of mast cell activation (GO:0033005)3.95217471
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.94043072
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91396382
36neuronal action potential propagation (GO:0019227)3.86030704
37regulation of gamma-delta T cell activation (GO:0046643)3.84977145
38regulation of synaptic vesicle exocytosis (GO:2000300)3.83254152
39neuron recognition (GO:0008038)3.81477580
40response to histamine (GO:0034776)3.80545261
41presynaptic membrane assembly (GO:0097105)3.80154030
42macrophage activation involved in immune response (GO:0002281)3.76000972
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.75127841
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.66711663
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66353074
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65962816
47cellular extravasation (GO:0045123)3.64318229
48axonal fasciculation (GO:0007413)3.64118104
49negative regulation of interleukin-12 production (GO:0032695)3.61596285
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61191463
51dendritic spine morphogenesis (GO:0060997)3.60591663
52detection of other organism (GO:0098543)3.59715548
53leukocyte migration involved in inflammatory response (GO:0002523)3.59556526
54neutrophil activation (GO:0042119)3.58627167
55regulation of postsynaptic membrane potential (GO:0060078)3.57242011
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56447671
57glutamate secretion (GO:0014047)3.55956808
58regulation of neuronal synaptic plasticity (GO:0048168)3.55170191
59regulation of mast cell activation (GO:0033003)3.55167667
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52661502
61transmission of nerve impulse (GO:0019226)3.51280915
62long-term memory (GO:0007616)3.48545587
63negative regulation of T cell mediated immunity (GO:0002710)3.48470829
64response to peptidoglycan (GO:0032494)3.45734166
65cellular potassium ion homeostasis (GO:0030007)3.43926454
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.43717342
67leukocyte aggregation (GO:0070486)3.43130567
68presynaptic membrane organization (GO:0097090)3.42747403
69postsynaptic membrane organization (GO:0001941)3.42091888
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.40973996
71auditory behavior (GO:0031223)3.40760362
72regulation of synaptic vesicle transport (GO:1902803)3.39213609
73regulation of dendritic spine morphogenesis (GO:0061001)3.38506579
74long-term synaptic potentiation (GO:0060291)3.38398724
75detection of bacterium (GO:0016045)3.37669970
76synaptic vesicle maturation (GO:0016188)3.36102970
77regulation of synapse structural plasticity (GO:0051823)3.33461566
78regulation of gamma-delta T cell differentiation (GO:0045586)3.33285194
79negative regulation of interleukin-1 production (GO:0032692)3.32887894
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32714756
81membrane hyperpolarization (GO:0060081)3.32285625
82cellular response to interleukin-15 (GO:0071350)3.31381556
83positive regulation of membrane potential (GO:0045838)3.28910811
84positive regulation of neurotransmitter transport (GO:0051590)3.27911990
85response to auditory stimulus (GO:0010996)3.26142032
86startle response (GO:0001964)3.24970698
87positive regulation of neurotransmitter secretion (GO:0001956)3.24646543
88positive regulation of mast cell activation involved in immune response (GO:0033008)3.23416384
89positive regulation of mast cell degranulation (GO:0043306)3.23416384
90neutrophil mediated immunity (GO:0002446)3.23164082
91negative regulation of interleukin-1 beta production (GO:0032691)3.22360550
92exploration behavior (GO:0035640)3.21244927
93response to interleukin-15 (GO:0070672)3.21240006
94synaptic transmission, dopaminergic (GO:0001963)3.19652145
95adaptation of signaling pathway (GO:0023058)3.18743052
96macrophage activation (GO:0042116)3.18683360
97L-fucose catabolic process (GO:0042355)3.18644473
98fucose catabolic process (GO:0019317)3.18644473
99L-fucose metabolic process (GO:0042354)3.18644473
100neurotransmitter secretion (GO:0007269)3.16082802
101negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15817918
102myeloid cell activation involved in immune response (GO:0002275)3.14378256
103behavioral response to cocaine (GO:0048148)3.13929424
104respiratory burst (GO:0045730)3.10886665
105granulocyte activation (GO:0036230)3.09401751
106detection of molecule of bacterial origin (GO:0032490)3.09219215
107regulation of synaptic plasticity (GO:0048167)3.09052138
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06542675
109negative regulation of leukocyte mediated immunity (GO:0002704)3.06416500
110regulation of glutamate secretion (GO:0014048)3.04977561
111regulation of interferon-beta biosynthetic process (GO:0045357)3.04962404
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03936138
113detection of external biotic stimulus (GO:0098581)3.03610935
114synapse assembly (GO:0007416)3.03520657
115striatum development (GO:0021756)3.02836628
116behavioral fear response (GO:0001662)3.02075592
117behavioral defense response (GO:0002209)3.02075592
118regulation of neurotransmitter secretion (GO:0046928)3.01937145
119negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01078818
120membrane depolarization (GO:0051899)3.01049564
121gamma-aminobutyric acid transport (GO:0015812)2.99696361
122substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.99206900
123substrate-independent telencephalic tangential migration (GO:0021826)2.99206900
124regulation of dendritic spine development (GO:0060998)2.98973577
125prepulse inhibition (GO:0060134)2.98715165
126positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98256359
127regulation of voltage-gated calcium channel activity (GO:1901385)2.96877726
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96789041
129response to host immune response (GO:0052572)2.96789041
130immunoglobulin mediated immune response (GO:0016064)2.95554000
131neurotransmitter transport (GO:0006836)2.93629218
132righting reflex (GO:0060013)2.93213907
133positive regulation of interleukin-1 beta secretion (GO:0050718)2.91953678
134leukocyte degranulation (GO:0043299)2.90125322
135positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89039346
136regulation of T cell mediated cytotoxicity (GO:0001914)2.89030523
137negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88999385
138regulation of mast cell degranulation (GO:0043304)2.87847904
139learning (GO:0007612)2.87771213
140mast cell activation (GO:0045576)2.87757721
141positive regulation of dendritic spine development (GO:0060999)2.87589480
142DNA deamination (GO:0045006)2.86944157
143regulation of vesicle fusion (GO:0031338)2.86574815
144positive regulation of synapse maturation (GO:0090129)2.86338321
145response to amphetamine (GO:0001975)2.86324398
146regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86140170
147fear response (GO:0042596)2.85920288
148interferon-gamma production (GO:0032609)2.85846316
149synaptic vesicle endocytosis (GO:0048488)2.85747083
150mechanosensory behavior (GO:0007638)2.85691755
151regulation of neurotransmitter transport (GO:0051588)2.84859910
152myeloid leukocyte mediated immunity (GO:0002444)2.84830962
153regulation of mast cell activation involved in immune response (GO:0033006)2.84661151
154detection of biotic stimulus (GO:0009595)2.84347546
155positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83828683
156proline transport (GO:0015824)2.83244530
157membrane depolarization during action potential (GO:0086010)2.83198372
158negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83197367
159antigen processing and presentation via MHC class Ib (GO:0002475)2.82151349
160B cell receptor signaling pathway (GO:0050853)2.80829144
161behavioral response to nicotine (GO:0035095)2.79058327
162positive regulation of dendritic spine morphogenesis (GO:0061003)2.77930276
163cytidine metabolic process (GO:0046087)2.77685523
164cytidine catabolic process (GO:0006216)2.77685523
165cytidine deamination (GO:0009972)2.77685523
166regulation of synapse maturation (GO:0090128)2.77376647
167negative T cell selection (GO:0043383)2.76100495
168layer formation in cerebral cortex (GO:0021819)2.75295330
169positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74005122
170L-amino acid import (GO:0043092)2.73391540
171positive regulation of synaptic transmission (GO:0050806)2.73206162
172female mating behavior (GO:0060180)2.72168458
173innervation (GO:0060384)2.71380901
174positive regulation of interleukin-1 secretion (GO:0050716)2.70929022
175synaptic transmission (GO:0007268)2.70902834
176negative thymic T cell selection (GO:0045060)2.70307262
177regulation of female receptivity (GO:0045924)2.69662941
178positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69367160
179dendrite development (GO:0016358)2.67362803
180neuronal ion channel clustering (GO:0045161)2.66915880
181regulation of B cell differentiation (GO:0045577)2.65222261
182positive thymic T cell selection (GO:0045059)2.63504016
183positive T cell selection (GO:0043368)2.62416570
184regulation of interleukin-1 beta secretion (GO:0050706)2.61964818
185production of molecular mediator involved in inflammatory response (GO:0002532)2.61189263
186negative regulation of interleukin-6 production (GO:0032715)2.59775765
187regulation of interleukin-6 biosynthetic process (GO:0045408)2.57400020
188regulation of myeloid leukocyte mediated immunity (GO:0002886)2.57379227
189negative regulation of adaptive immune response (GO:0002820)2.56996873
190regulation of regulatory T cell differentiation (GO:0045589)2.55265649
191regulation of memory T cell differentiation (GO:0043380)2.54306637
192superoxide anion generation (GO:0042554)2.53381140
193pyrimidine ribonucleoside catabolic process (GO:0046133)2.53242615
194regulation of alpha-beta T cell proliferation (GO:0046640)2.52293404
195dendritic cell migration (GO:0036336)2.50255500
196positive regulation of antigen processing and presentation (GO:0002579)2.49895822
197response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47856269
198response to host (GO:0075136)2.47856269
199response to host defenses (GO:0052200)2.47856269
200defense response to protozoan (GO:0042832)2.47236980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10787355
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.11147504
3GBX2_23144817_ChIP-Seq_PC3_Human4.02554330
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14423354
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96911514
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93356359
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.88797299
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88306580
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55434084
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55179625
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53508038
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51657593
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51657593
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.50404436
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44120350
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.44057603
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26747719
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23458986
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22543781
20ZNF274_21170338_ChIP-Seq_K562_Hela2.20014865
21DROSHA_22980978_ChIP-Seq_HELA_Human2.19149950
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.13934536
23RUNX_20019798_ChIP-Seq_JUKART_Human2.13558823
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13198159
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.11926396
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07769386
27REST_21632747_ChIP-Seq_MESCs_Mouse2.05271383
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03807609
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03400592
30AR_21572438_ChIP-Seq_LNCaP_Human1.96137011
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93376584
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88488748
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88039553
34TAF15_26573619_Chip-Seq_HEK293_Human1.87714011
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86908934
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86791844
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83598436
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.81837374
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80483728
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74055955
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73099750
42* RARB_27405468_Chip-Seq_BRAIN_Mouse1.70872822
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70579126
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69448227
45P300_19829295_ChIP-Seq_ESCs_Human1.68893505
46SMAD4_21799915_ChIP-Seq_A2780_Human1.68665530
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.68574618
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67154485
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55660928
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.53892649
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53781716
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.53172447
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51717351
54GATA3_26560356_Chip-Seq_TH2_Human1.50496028
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50154712
56VDR_22108803_ChIP-Seq_LS180_Human1.49898017
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.49052156
58VDR_24787735_ChIP-Seq_THP-1_Human1.47046275
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46376956
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45213766
61SCL_19346495_ChIP-Seq_HPC-7_Human1.44415979
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.44075010
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41400696
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40239524
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39968886
66FUS_26573619_Chip-Seq_HEK293_Human1.39338141
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35139322
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34767064
69RNF2_27304074_Chip-Seq_NSC_Mouse1.33718419
70MYB_26560356_Chip-Seq_TH2_Human1.33140750
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32777837
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31004902
73GATA3_27048872_Chip-Seq_THYMUS_Human1.30635153
74SPI1_23127762_ChIP-Seq_K562_Human1.29109684
75STAT3_23295773_ChIP-Seq_U87_Human1.28120221
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.27701065
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.26800537
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26706195
79AR_25329375_ChIP-Seq_VCAP_Human1.26589486
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26238276
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24922222
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24478695
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23897282
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23612259
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23188384
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23123155
87IGF1R_20145208_ChIP-Seq_DFB_Human1.22889791
88AHR_22903824_ChIP-Seq_MCF-7_Human1.22710564
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.22511276
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22095522
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21918240
92* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20162702
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19554617
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.19549103
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19317085
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18849317
97SPI1_23547873_ChIP-Seq_NB4_Human1.17479735
98TP53_16413492_ChIP-PET_HCT116_Human1.17395432
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16193373
100TP53_18474530_ChIP-ChIP_U2OS_Human1.16150783
101SMRT_27268052_Chip-Seq_Bcells_Human1.16038861
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15582888
103* TCF4_23295773_ChIP-Seq_U87_Human1.15199681
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13443187
105* ER_23166858_ChIP-Seq_MCF-7_Human1.13128364
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12671425
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.11359507
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11281432
109GATA3_21878914_ChIP-Seq_MCF-7_Human1.11059729
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10681556
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10681556
112BCAT_22108803_ChIP-Seq_LS180_Human1.10672825
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10451817
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.10305799
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.10211873
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09776605
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09230501
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09113678
119RUNX2_22187159_ChIP-Seq_PCA_Human1.08374018
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08201597
121TP53_22573176_ChIP-Seq_HFKS_Human1.08125046
122* SMAD3_21741376_ChIP-Seq_HESCs_Human1.07814271
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07752014
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06787179
125* FLI1_21867929_ChIP-Seq_TH2_Mouse1.06219077
126E2F1_18555785_Chip-Seq_ESCs_Mouse1.05850260
127AR_19668381_ChIP-Seq_PC3_Human1.05301056
128* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03152978
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01926756
130NANOG_19829295_ChIP-Seq_ESCs_Human1.00853418
131SOX2_19829295_ChIP-Seq_ESCs_Human1.00853418
132FLI1_27457419_Chip-Seq_LIVER_Mouse1.00540668
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00426044
134P53_22387025_ChIP-Seq_ESCs_Mouse1.00260705
135PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00040106
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99839751
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99673684
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99640463
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.99392873
140GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99060081
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98198009
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97980531
143TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97845534
144SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97136719
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96772178
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.96772178
147EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96352432
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.95280660
149* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94937114
150FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94058506
151GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93874280
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93469822
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89584067
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89296155
155RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88791891
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88733047
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.88558687
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.88526846
159GATA3_26560356_Chip-Seq_TH1_Human0.88116470
160IRF1_19129219_ChIP-ChIP_H3396_Human0.88028770
161CBP_20019798_ChIP-Seq_JUKART_Human0.87887049
162IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87887049
163Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87002922
164TCF4_22108803_ChIP-Seq_LS180_Human0.86323538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.93271756
2MP0003880_abnormal_central_pattern4.89738328
3MP0003724_increased_susceptibility_to4.01050291
4MP0003635_abnormal_synaptic_transmissio3.54001067
5MP0002822_catalepsy3.50350976
6MP0000569_abnormal_digit_pigmentation3.44273457
7MP0001835_abnormal_antigen_presentation3.40051522
8MP0009745_abnormal_behavioral_response3.16340187
9MP0004270_analgesia2.96372686
10MP0005671_abnormal_response_to2.92678946
11MP0002063_abnormal_learning/memory/cond2.92662692
12MP0009046_muscle_twitch2.80833798
13MP0001968_abnormal_touch/_nociception2.80430968
14MP0001486_abnormal_startle_reflex2.80167306
15MP0002064_seizures2.78624390
16MP0002572_abnormal_emotion/affect_behav2.63332084
17MP0005423_abnormal_somatic_nervous2.58302932
18MP0001984_abnormal_olfaction2.51337793
19MP0001800_abnormal_humoral_immune2.49807136
20MP0003436_decreased_susceptibility_to2.48312160
21MP0002272_abnormal_nervous_system2.42805143
22MP0001986_abnormal_taste_sensitivity2.39069720
23MP0005551_abnormal_eye_electrophysiolog2.35425761
24MP0001501_abnormal_sleep_pattern2.33240547
25MP0002419_abnormal_innate_immunity2.30206368
26MP0002734_abnormal_mechanical_nocicepti2.30007971
27MP0009785_altered_susceptibility_to2.21357044
28MP0000685_abnormal_immune_system2.19836087
29MP0005646_abnormal_pituitary_gland2.15582801
30MP0005387_immune_system_phenotype2.14764135
31MP0001790_abnormal_immune_system2.14764135
32MP0001188_hyperpigmentation2.14178017
33MP0002736_abnormal_nociception_after2.13785134
34MP0001440_abnormal_grooming_behavior2.13204704
35MP0002723_abnormal_immune_serum2.12139175
36MP0002735_abnormal_chemical_nociception2.11148109
37MP0005025_abnormal_response_to2.10617289
38MP0005000_abnormal_immune_tolerance2.09757196
39MP0006082_CNS_inflammation2.07061410
40MP0002254_reproductive_system_inflammat2.02257269
41MP0002452_abnormal_antigen_presenting2.00975038
42MP0002420_abnormal_adaptive_immunity1.98683951
43MP0001819_abnormal_immune_cell1.96610538
44MP0003303_peritoneal_inflammation1.91927580
45MP0005645_abnormal_hypothalamus_physiol1.88250052
46MP0003879_abnormal_hair_cell1.84457145
47MP0002067_abnormal_sensory_capabilities1.82338225
48MP0002557_abnormal_social/conspecific_i1.77453221
49MP0000778_abnormal_nervous_system1.72936784
50MP0001529_abnormal_vocalization1.72492179
51MP0002148_abnormal_hypersensitivity_rea1.71772735
52MP0003195_calcinosis1.70005956
53MP0009764_decreased_sensitivity_to1.68206625
54MP0002184_abnormal_innervation1.64822644
55MP0001970_abnormal_pain_threshold1.64731846
56MP0002733_abnormal_thermal_nociception1.63109737
57MP0005409_darkened_coat_color1.62768558
58MP0009780_abnormal_chondrocyte_physiolo1.62632290
59MP0002876_abnormal_thyroid_physiology1.61110842
60MP0001346_abnormal_lacrimal_gland1.59894327
61MP0005075_abnormal_melanosome_morpholog1.57664526
62MP0005174_abnormal_tail_pigmentation1.56416895
63MP0008877_abnormal_DNA_methylation1.55854021
64MP0001502_abnormal_circadian_rhythm1.52904959
65MP0008569_lethality_at_weaning1.52641770
66MP0003172_abnormal_lysosome_physiology1.49648924
67MP0004924_abnormal_behavior1.49035015
68MP0005386_behavior/neurological_phenoty1.49035015
69MP0005253_abnormal_eye_physiology1.41922700
70MP0002882_abnormal_neuron_morphology1.39823705
71MP0000716_abnormal_immune_system1.39025171
72MP0002277_abnormal_respiratory_mucosa1.38098887
73MP0006072_abnormal_retinal_apoptosis1.35633954
74MP0004742_abnormal_vestibular_system1.34516001
75MP0002909_abnormal_adrenal_gland1.33915433
76MP0004381_abnormal_hair_follicle1.31752277
77MP0006276_abnormal_autonomic_nervous1.31214013
78MP0002405_respiratory_system_inflammati1.30747024
79MP0003646_muscle_fatigue1.30697221
80MP0003787_abnormal_imprinting1.28164530
81MP0003866_abnormal_defecation1.27638044
82MP0001845_abnormal_inflammatory_respons1.27634904
83MP0001905_abnormal_dopamine_level1.27477078
84MP0002398_abnormal_bone_marrow1.26367233
85MP0000015_abnormal_ear_pigmentation1.26144323
86MP0003763_abnormal_thymus_physiology1.25510714
87MP0003136_yellow_coat_color1.23684545
88MP0001533_abnormal_skeleton_physiology1.23449464
89MP0004885_abnormal_endolymph1.22211338
90MP0006292_abnormal_olfactory_placode1.20637695
91MP0005464_abnormal_platelet_physiology1.19657601
92MP0002090_abnormal_vision1.19299836
93MP0002066_abnormal_motor_capabilities/c1.18245097
94MP0002102_abnormal_ear_morphology1.17101816
95MP0000689_abnormal_spleen_morphology1.16448776
96MP0004130_abnormal_muscle_cell1.15946096
97MP0002928_abnormal_bile_duct1.15543097
98MP0002653_abnormal_ependyma_morphology1.12796499
99MP0004142_abnormal_muscle_tone1.12258120
100MP0001485_abnormal_pinna_reflex1.11756351
101MP0002752_abnormal_somatic_nervous1.11447040
102MP0003329_amyloid_beta_deposits1.10807312
103MP0004811_abnormal_neuron_physiology1.10264119
104MP0002138_abnormal_hepatobiliary_system1.09515824
105MP0000955_abnormal_spinal_cord1.09126118
106MP0002638_abnormal_pupillary_reflex1.09099235
107MP0003183_abnormal_peptide_metabolism1.08866196
108MP0001963_abnormal_hearing_physiology1.08074976
109MP0004858_abnormal_nervous_system1.06257113
110MP0002229_neurodegeneration1.05917512
111MP0003045_fibrosis1.03385080
112MP0002722_abnormal_immune_system1.02707020
113MP0008469_abnormal_protein_level1.02324618
114MP0005394_taste/olfaction_phenotype1.02245486
115MP0005499_abnormal_olfactory_system1.02245486
116MP0005084_abnormal_gallbladder_morpholo1.00938768
117MP0000631_abnormal_neuroendocrine_gland1.00139617
118MP0010155_abnormal_intestine_physiology0.97679876
119MP0000026_abnormal_inner_ear0.96733035
120MP0010386_abnormal_urinary_bladder0.96268352
121MP0003633_abnormal_nervous_system0.95516600
122MP0002429_abnormal_blood_cell0.94959599
123MP0001177_atelectasis0.92620121
124MP0008872_abnormal_physiological_respon0.92449658
125MP0002152_abnormal_brain_morphology0.92301583
126MP0002837_dystrophic_cardiac_calcinosis0.91490055
127MP0004883_abnormal_blood_vessel0.90030231
128MP0005167_abnormal_blood-brain_barrier0.89835530
129MP0000427_abnormal_hair_cycle0.87190694
130MP0003878_abnormal_ear_physiology0.87133274
131MP0005377_hearing/vestibular/ear_phenot0.87133274
132MP0005195_abnormal_posterior_eye0.85859731
133MP0002132_abnormal_respiratory_system0.83865213
134MP0003690_abnormal_glial_cell0.83604709
135MP0003828_pulmonary_edema0.82687436
136MP0009278_abnormal_bone_marrow0.81765758
137MP0002095_abnormal_skin_pigmentation0.81626497
138MP0000703_abnormal_thymus_morphology0.80649508
139MP0002693_abnormal_pancreas_physiology0.80356602
140MP0005171_absent_coat_pigmentation0.79669466
141MP0003631_nervous_system_phenotype0.79413688
142MP0002069_abnormal_eating/drinking_beha0.79256991
143MP0008004_abnormal_stomach_pH0.79177732
144MP0008874_decreased_physiological_sensi0.77353208
145MP0001663_abnormal_digestive_system0.76924608
146MP0001664_abnormal_digestion0.75938829
147MP0004085_abnormal_heartbeat0.72632756
148MP0000465_gastrointestinal_hemorrhage0.71628568
149MP0004145_abnormal_muscle_electrophysio0.71427438
150MP0003938_abnormal_ear_development0.71072152
151MP0003634_abnormal_glial_cell0.70038877
152MP0003011_delayed_dark_adaptation0.69882432
153MP0005310_abnormal_salivary_gland0.69859112
154MP0004215_abnormal_myocardial_fiber0.69412422
155MP0000920_abnormal_myelination0.64480064
156MP0003075_altered_response_to0.64437821
157MP0008789_abnormal_olfactory_epithelium0.61153734
158MP0001348_abnormal_lacrimal_gland0.58158427
159MP0005535_abnormal_body_temperature0.57974685
160MP0001943_abnormal_respiration0.56799749
161MP0004484_altered_response_of0.56441966
162MP0003137_abnormal_impulse_conducting0.54275445
163MP0000566_synostosis0.52234623
164MP0002249_abnormal_larynx_morphology0.51105594
165MP0004510_myositis0.49932729

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.15906071
2Stomatitis (HP:0010280)4.92436110
3Myokymia (HP:0002411)4.81431789
4Focal seizures (HP:0007359)4.70816160
5Epileptic encephalopathy (HP:0200134)4.70503391
6Retrobulbar optic neuritis (HP:0100654)4.65088694
7Optic neuritis (HP:0100653)4.65088694
8Congenital stationary night blindness (HP:0007642)4.65060612
9Myositis (HP:0100614)4.61974818
10Febrile seizures (HP:0002373)4.48645257
11Orchitis (HP:0100796)4.37755746
12Elevated erythrocyte sedimentation rate (HP:0003565)4.37080872
13Recurrent bacterial skin infections (HP:0005406)4.32903021
14Recurrent abscess formation (HP:0002722)4.25718533
15Absent/shortened dynein arms (HP:0200106)3.91138224
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.91138224
17Abnormal ciliary motility (HP:0012262)3.80999795
18Atonic seizures (HP:0010819)3.76285908
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.67188088
20Eczematoid dermatitis (HP:0000976)3.62241962
21Absence seizures (HP:0002121)3.59886671
22Abnormal respiratory motile cilium physiology (HP:0012261)3.58417245
23Hyperventilation (HP:0002883)3.53019113
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.52867555
25Progressive cerebellar ataxia (HP:0002073)3.48740245
26Recurrent gram-negative bacterial infections (HP:0005420)3.38712371
27Recurrent fungal infections (HP:0002841)3.38045612
28Amblyopia (HP:0000646)3.33753194
29Generalized tonic-clonic seizures (HP:0002069)3.33191034
30Dialeptic seizures (HP:0011146)3.32874562
31Broad-based gait (HP:0002136)3.32145959
32Abnormality of macrophages (HP:0004311)3.31941572
33Visual hallucinations (HP:0002367)3.24655036
34Gastrointestinal infarctions (HP:0005244)3.22901439
35Recurrent cutaneous fungal infections (HP:0011370)3.21909409
36Chronic mucocutaneous candidiasis (HP:0002728)3.21909409
37Stomach cancer (HP:0012126)3.16832757
38Abnormality of macular pigmentation (HP:0008002)3.16568081
39Encephalitis (HP:0002383)3.13584840
40Recurrent skin infections (HP:0001581)3.10427695
41Abnormal respiratory motile cilium morphology (HP:0005938)3.10150289
42Abnormal respiratory epithelium morphology (HP:0012253)3.10150289
43Keratoconjunctivitis (HP:0001096)3.09375557
44Nuclear cataract (HP:0100018)3.07874600
45Dyschromatopsia (HP:0007641)3.04828094
46Keratoconjunctivitis sicca (HP:0001097)3.02787103
47Hypochromic microcytic anemia (HP:0004840)3.00687547
48Hemiplegia (HP:0002301)2.97991545
49Decreased central vision (HP:0007663)2.90297650
50Hemoptysis (HP:0002105)2.86352430
51Pancreatic cysts (HP:0001737)2.83540226
52Meningitis (HP:0001287)2.83013126
53Gaze-evoked nystagmus (HP:0000640)2.78467156
54Abnormality of T cell number (HP:0011839)2.76130319
55Vasculitis (HP:0002633)2.72901499
56Hypochromic anemia (HP:0001931)2.71331044
57Leukocytosis (HP:0001974)2.70733743
58Chronic otitis media (HP:0000389)2.70178864
59Episodic fever (HP:0001954)2.66043392
60Gait imbalance (HP:0002141)2.65710078
61Congenital primary aphakia (HP:0007707)2.65415300
62Zonular cataract (HP:0010920)2.61914254
63T lymphocytopenia (HP:0005403)2.57087602
64Obstructive lung disease (HP:0006536)2.56426794
65Chronic obstructive pulmonary disease (HP:0006510)2.56426794
66Mediastinal lymphadenopathy (HP:0100721)2.56420305
67Dysdiadochokinesis (HP:0002075)2.55397988
68Neurofibrillary tangles (HP:0002185)2.54881176
69Supranuclear gaze palsy (HP:0000605)2.53194299
70Drooling (HP:0002307)2.49204729
71Excessive salivation (HP:0003781)2.49204729
72Pulmonary infiltrates (HP:0002113)2.49175534
73Abolished electroretinogram (ERG) (HP:0000550)2.48689658
74Hemiparesis (HP:0001269)2.47322504
75Poor eye contact (HP:0000817)2.45953965
76Bony spicule pigmentary retinopathy (HP:0007737)2.45055976
77Medial flaring of the eyebrow (HP:0010747)2.44933033
78Central scotoma (HP:0000603)2.43399594
79Attenuation of retinal blood vessels (HP:0007843)2.42271882
80Rhinitis (HP:0012384)2.41643826
81* Amelogenesis imperfecta (HP:0000705)2.41341288
82Aplasia involving bones of the extremities (HP:0009825)2.40924221
83Aplasia involving bones of the upper limbs (HP:0009823)2.40924221
84Aplasia of the phalanges of the hand (HP:0009802)2.40924221
85Action tremor (HP:0002345)2.39490923
86Dysmetria (HP:0001310)2.38977018
87Panhypogammaglobulinemia (HP:0003139)2.36866260
88Abnormality of T cells (HP:0002843)2.33947861
89Anxiety (HP:0000739)2.29867621
90Absent speech (HP:0001344)2.29133727
91Chest pain (HP:0100749)2.28179875
92Molar tooth sign on MRI (HP:0002419)2.27176281
93Abnormality of midbrain morphology (HP:0002418)2.27176281
94Nephrogenic diabetes insipidus (HP:0009806)2.24029472
95Abnormality of binocular vision (HP:0011514)2.23373427
96Diplopia (HP:0000651)2.23373427
97Urticaria (HP:0001025)2.20424216
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.19084873
99Cerebral inclusion bodies (HP:0100314)2.17505425
100Truncal ataxia (HP:0002078)2.17287109
101Anorexia (HP:0002039)2.16686812
102Genital tract atresia (HP:0001827)2.15946152
103Abnormal social behavior (HP:0012433)2.15004132
104Impaired social interactions (HP:0000735)2.15004132
105Prolonged bleeding time (HP:0003010)2.14944712
106Pulmonary embolism (HP:0002204)2.14451146
107Genetic anticipation (HP:0003743)2.13446145
108Arterial thrombosis (HP:0004420)2.13424760
109Progressive inability to walk (HP:0002505)2.13156760
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12115520
111Increased cerebral lipofuscin (HP:0011813)2.11411554
112Type II lissencephaly (HP:0007260)2.11224967
113Eosinophilia (HP:0001880)2.10030385
114Epileptiform EEG discharges (HP:0011182)2.09150711
115Impaired vibration sensation in the lower limbs (HP:0002166)2.09124942
116Vaginal atresia (HP:0000148)2.08971736
117Urinary bladder sphincter dysfunction (HP:0002839)2.08934576
118Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08003251
119Onycholysis (HP:0001806)2.05836818
120Abnormality of eosinophils (HP:0001879)2.05081052
121Abnormality of salivation (HP:0100755)2.04962751
122Abnormal rod and cone electroretinograms (HP:0008323)2.04856802
123Pustule (HP:0200039)2.04758167
124Abnormal drinking behavior (HP:0030082)2.03616491
125Polydipsia (HP:0001959)2.03616491
126Nephronophthisis (HP:0000090)2.03493757
127Spontaneous hematomas (HP:0007420)2.02562528
128Inability to walk (HP:0002540)2.01759130
129Thickened helices (HP:0000391)2.01476275
130Gangrene (HP:0100758)2.01069027
131Vertigo (HP:0002321)2.00623080
132Prolonged QT interval (HP:0001657)1.99122637
133Megalencephaly (HP:0001355)1.99081275
134Agitation (HP:0000713)1.97748128
135Scanning speech (HP:0002168)1.97154658
136Stereotypic behavior (HP:0000733)1.95494657
137Ankle clonus (HP:0011448)1.94749100
138Aplasia/Hypoplasia of the lens (HP:0008063)1.94306442
139Constricted visual fields (HP:0001133)1.94225217
140Abnormality of the pleura (HP:0002103)1.93795996
141Abnormality of T cell physiology (HP:0011840)1.93608081
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93204543
143Postural instability (HP:0002172)1.92162967
144Depression (HP:0000716)1.91985662
145Recurrent bronchitis (HP:0002837)1.91737757
146Amyloidosis (HP:0011034)1.91124070
147EEG with generalized epileptiform discharges (HP:0011198)1.89801712
148Abnormality of the renal cortex (HP:0011035)1.89129604
149Scotoma (HP:0000575)1.88909150
150Septo-optic dysplasia (HP:0100842)1.85713061
151Severe visual impairment (HP:0001141)1.85047409
152Lower limb amyotrophy (HP:0007210)1.83306605
153Widely spaced teeth (HP:0000687)1.82361011
154Hypothermia (HP:0002045)1.82260199
155Gingival bleeding (HP:0000225)1.82023260
156Tubulointerstitial nephritis (HP:0001970)1.81572163
157Blue irides (HP:0000635)1.81369460
158Abnormality of the renal medulla (HP:0100957)1.81237326
159Chronic sinusitis (HP:0011109)1.80459331
160Gingivitis (HP:0000230)1.80159968
161Granulocytopenia (HP:0001913)1.80074444
162IgG deficiency (HP:0004315)1.79960248
163Clumsiness (HP:0002312)1.76892392
164Status epilepticus (HP:0002133)1.76724235
165Abnormal eating behavior (HP:0100738)1.76301002
166Impaired smooth pursuit (HP:0007772)1.76192208
167Alveolar cell carcinoma (HP:0006519)1.75470745
168Macular degeneration (HP:0000608)1.75161963
169Retinal dysplasia (HP:0007973)1.75064408
170Exotropia (HP:0000577)1.74597304
171Abnormal EKG (HP:0003115)1.74404500
172True hermaphroditism (HP:0010459)1.73626563
173Pancreatic fibrosis (HP:0100732)1.72349919
174Specific learning disability (HP:0001328)1.71012159
175Spastic gait (HP:0002064)1.69370722
176Poor coordination (HP:0002370)1.68154039
177Lower limb muscle weakness (HP:0007340)1.67879129
178Corneal dystrophy (HP:0001131)1.67543144
179Abnormality of calcium-phosphate metabolism (HP:0100530)1.67405619
180Torticollis (HP:0000473)1.66785558
181Protruding tongue (HP:0010808)1.66452531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.95025576
2NTRK34.26062592
3FRK3.95558121
4CASK3.66687786
5TAOK32.86983861
6MAP4K12.78501192
7TXK2.76341353
8MAP3K42.67942869
9TNIK2.62091747
10MAP2K72.47577407
11MARK12.35703551
12DAPK22.21156384
13NTRK22.19539523
14MAP3K92.03022821
15RIPK42.02993609
16IRAK41.97413567
17PNCK1.87411771
18GRK61.85045664
19SYK1.80581779
20CSK1.78671556
21TLK11.74654975
22BMPR1B1.72524653
23FES1.66229656
24TYK21.63796538
25ACVR1B1.62623775
26PAK61.59680261
27MINK11.57058010
28PINK11.45146866
29BTK1.42666694
30ZAK1.38915110
31ZAP701.38767077
32SIK21.38481980
33MAP3K131.38217279
34MAP2K31.35325658
35CDK51.34323102
36MAPK131.33850855
37PLK21.31606308
38GRK11.30870936
39IKBKE1.28399620
40TEC1.26813630
41KIT1.26465102
42HCK1.26056630
43GRK51.25788748
44BMPR21.23148056
45CAMK2A1.21318224
46LYN1.20599975
47MAP2K41.19851548
48NTRK11.19552571
49ITK1.18182006
50NME11.15329868
51PRKCG1.13807727
52CAMK2B1.11231398
53MAP3K121.09930080
54PRPF4B1.08357261
55JAK31.07408355
56IKBKB1.06437429
57DAPK11.05535880
58NEK61.04999645
59JAK21.03336736
60MAP4K21.02632230
61LCK1.02343280
62MAP3K141.01755309
63IRAK11.01280010
64CDK30.97658083
65KSR10.97610371
66FGR0.97225294
67DYRK1A0.95414813
68CSF1R0.94320049
69SGK2230.94303994
70SGK4940.94303994
71CAMKK10.93263649
72PIK3CG0.93259435
73PTK2B0.93002636
74MAP3K110.89892646
75SGK10.89823298
76CAMK10.88804070
77PRKCE0.88499560
78JAK10.88129499
79SGK20.88055095
80KSR20.87931586
81AKT30.85030973
82MARK30.84838480
83PRKD30.84748073
84STK380.83175056
85OXSR10.82622037
86STK110.82615333
87INSRR0.81798957
88MARK20.81512804
89MAPK150.81353821
90PHKG20.78730510
91PHKG10.78730510
92TYRO30.78141046
93WNK30.77704343
94CAMK1G0.76515050
95PKN10.75045313
96PAK30.73350898
97CAMK2D0.72411010
98GRK70.69850570
99MAP2K60.68741787
100NUAK10.68365276
101FER0.66390462
102MUSK0.66147891
103MAP3K20.66145896
104WNK10.65267408
105ARAF0.64939970
106PRKCH0.64781313
107FGFR20.64635434
108CDC42BPA0.63983607
109UHMK10.63167542
110ADRBK20.62461377
111MAP3K10.60909662
112NLK0.59926267
113WNK40.57212893
114TAOK10.57055922
115TNK20.56796492
116CAMKK20.56387161
117BLK0.56256539
118CDK180.52795798
119PDPK10.52262453
120ADRBK10.52250058
121ROCK20.52148744
122MATK0.52027805
123STK390.51896622
124EPHA30.51755746
125CDK150.51659746
126CDK190.51559508
127CAMK2G0.50285158
128PRKCZ0.49906616
129FYN0.49705050
130SGK30.48906435
131YES10.48413457
132MAP3K30.48234109
133BCR0.48078929
134MAPK120.48047784
135MAP3K70.47285784
136CDK140.46623465
137PRKACA0.46340318
138PRKCB0.46161211
139TBK10.45839391
140PRKG10.45248998
141RAF10.45089617
142RPS6KA30.44677177
143CAMK40.43916201
144CDK11A0.43701213
145PRKCA0.42444047
146PDK10.41958096
147PRKCQ0.41687903
148IRAK20.41592585
149PIM10.41294470
150PRKAA20.41221619
151MAPK100.40160154
152PRKD20.40100141
153MAPK70.39422953
154DMPK0.38502752

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98207637
2Phototransduction_Homo sapiens_hsa047443.08590734
3* Olfactory transduction_Homo sapiens_hsa047402.94514011
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85949284
5Morphine addiction_Homo sapiens_hsa050322.81272798
6GABAergic synapse_Homo sapiens_hsa047272.76582547
7Glutamatergic synapse_Homo sapiens_hsa047242.75274649
8Circadian entrainment_Homo sapiens_hsa047132.72434741
9Graft-versus-host disease_Homo sapiens_hsa053322.61929275
10Amphetamine addiction_Homo sapiens_hsa050312.48969294
11Staphylococcus aureus infection_Homo sapiens_hsa051502.45708165
12Synaptic vesicle cycle_Homo sapiens_hsa047212.43772660
13Allograft rejection_Homo sapiens_hsa053302.39081429
14Leishmaniasis_Homo sapiens_hsa051402.38973762
15Long-term potentiation_Homo sapiens_hsa047202.34357029
16Salivary secretion_Homo sapiens_hsa049702.32215095
17Autoimmune thyroid disease_Homo sapiens_hsa053202.27241704
18Primary immunodeficiency_Homo sapiens_hsa053402.20853686
19Intestinal immune network for IgA production_Homo sapiens_hsa046722.14673792
20Osteoclast differentiation_Homo sapiens_hsa043802.10740415
21Serotonergic synapse_Homo sapiens_hsa047262.06028691
22Taste transduction_Homo sapiens_hsa047422.05596025
23Dopaminergic synapse_Homo sapiens_hsa047282.02481458
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94696927
25Asthma_Homo sapiens_hsa053101.92289816
26Insulin secretion_Homo sapiens_hsa049111.88439919
27Cholinergic synapse_Homo sapiens_hsa047251.87511987
28Gastric acid secretion_Homo sapiens_hsa049711.84890999
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84860968
30Calcium signaling pathway_Homo sapiens_hsa040201.82880796
31Renin secretion_Homo sapiens_hsa049241.79250766
32Tuberculosis_Homo sapiens_hsa051521.75833270
33Cocaine addiction_Homo sapiens_hsa050301.74805433
34Long-term depression_Homo sapiens_hsa047301.64809643
35Oxytocin signaling pathway_Homo sapiens_hsa049211.64455507
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61926158
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58516174
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57275635
39Hematopoietic cell lineage_Homo sapiens_hsa046401.47917420
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43881022
41Nitrogen metabolism_Homo sapiens_hsa009101.42721551
42Antigen processing and presentation_Homo sapiens_hsa046121.42170861
43Linoleic acid metabolism_Homo sapiens_hsa005911.41006456
44T cell receptor signaling pathway_Homo sapiens_hsa046601.37828187
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37776452
46GnRH signaling pathway_Homo sapiens_hsa049121.35670143
47B cell receptor signaling pathway_Homo sapiens_hsa046621.35358484
48cAMP signaling pathway_Homo sapiens_hsa040241.35245371
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29496651
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29488294
51Axon guidance_Homo sapiens_hsa043601.27867212
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23264709
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23154758
54Collecting duct acid secretion_Homo sapiens_hsa049661.20621263
55Gap junction_Homo sapiens_hsa045401.16980577
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16019156
57Malaria_Homo sapiens_hsa051441.09686230
58Regulation of autophagy_Homo sapiens_hsa041401.08928606
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.08387940
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06607798
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06599300
62Melanogenesis_Homo sapiens_hsa049161.05733217
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05684862
64Platelet activation_Homo sapiens_hsa046111.04868520
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02571386
66Cardiac muscle contraction_Homo sapiens_hsa042601.01778893
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01755454
68NF-kappa B signaling pathway_Homo sapiens_hsa040641.00869554
69Legionellosis_Homo sapiens_hsa051340.98856038
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95911112
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.95701917
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95168774
73Pancreatic secretion_Homo sapiens_hsa049720.93568509
74Viral myocarditis_Homo sapiens_hsa054160.93134390
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92599731
76African trypanosomiasis_Homo sapiens_hsa051430.90768706
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89813032
78Phagosome_Homo sapiens_hsa041450.88814426
79Measles_Homo sapiens_hsa051620.88680711
80ErbB signaling pathway_Homo sapiens_hsa040120.87013498
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86955128
82Estrogen signaling pathway_Homo sapiens_hsa049150.85671875
83Type II diabetes mellitus_Homo sapiens_hsa049300.84783362
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84442190
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83988976
86Dilated cardiomyopathy_Homo sapiens_hsa054140.81696200
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.80535138
88Circadian rhythm_Homo sapiens_hsa047100.80094528
89Choline metabolism in cancer_Homo sapiens_hsa052310.79076219
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78878979
91Toxoplasmosis_Homo sapiens_hsa051450.78784292
92Vibrio cholerae infection_Homo sapiens_hsa051100.76129714
93Glioma_Homo sapiens_hsa052140.76094065
94Arachidonic acid metabolism_Homo sapiens_hsa005900.75958369
95Ras signaling pathway_Homo sapiens_hsa040140.74289250
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73939188
97ABC transporters_Homo sapiens_hsa020100.73481516
98MAPK signaling pathway_Homo sapiens_hsa040100.71801694
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70849774
100Influenza A_Homo sapiens_hsa051640.70752310
101Thyroid hormone synthesis_Homo sapiens_hsa049180.69846655
102Dorso-ventral axis formation_Homo sapiens_hsa043200.69439867
103TNF signaling pathway_Homo sapiens_hsa046680.68703167
104Rap1 signaling pathway_Homo sapiens_hsa040150.65918278
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.65308550
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62119481
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61432636
108Ovarian steroidogenesis_Homo sapiens_hsa049130.59847185
109Wnt signaling pathway_Homo sapiens_hsa043100.58078380
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57501957
111Alzheimers disease_Homo sapiens_hsa050100.56904769
112Herpes simplex infection_Homo sapiens_hsa051680.56599116
113Pertussis_Homo sapiens_hsa051330.55696698
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54669600
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53440234
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52669906
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.52660957
118Sphingolipid metabolism_Homo sapiens_hsa006000.50844721
119Glycerolipid metabolism_Homo sapiens_hsa005610.50083402
120Ether lipid metabolism_Homo sapiens_hsa005650.50083222
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48052405
122Mineral absorption_Homo sapiens_hsa049780.46568354
123Inositol phosphate metabolism_Homo sapiens_hsa005620.45023196
124Lysosome_Homo sapiens_hsa041420.43200030
125Alcoholism_Homo sapiens_hsa050340.42013313
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39721576
127Fatty acid biosynthesis_Homo sapiens_hsa000610.39520465
128VEGF signaling pathway_Homo sapiens_hsa043700.39071340
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38672237
130Rheumatoid arthritis_Homo sapiens_hsa053230.38219616
131Oxidative phosphorylation_Homo sapiens_hsa001900.35866348
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34454161
133Chemokine signaling pathway_Homo sapiens_hsa040620.34404433
134Melanoma_Homo sapiens_hsa052180.33999155
135Type I diabetes mellitus_Homo sapiens_hsa049400.33390382
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28346941
137Glucagon signaling pathway_Homo sapiens_hsa049220.27148339
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26899950
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.25500021
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23867680
141Oocyte meiosis_Homo sapiens_hsa041140.23547504
142Bile secretion_Homo sapiens_hsa049760.22160175
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21613800
144Renal cell carcinoma_Homo sapiens_hsa052110.19263041
145Prion diseases_Homo sapiens_hsa050200.19022647
146Hedgehog signaling pathway_Homo sapiens_hsa043400.18169925
147Parkinsons disease_Homo sapiens_hsa050120.17486489
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17014721

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