SLC22A25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)5.59144842
2exogenous drug catabolic process (GO:0042738)5.36263194
3tryptophan catabolic process (GO:0006569)5.05020732
4indole-containing compound catabolic process (GO:0042436)5.05020732
5indolalkylamine catabolic process (GO:0046218)5.05020732
6indolalkylamine metabolic process (GO:0006586)4.50853635
7tryptophan metabolic process (GO:0006568)4.34835287
8oxidative demethylation (GO:0070989)4.31142658
9cellular ketone body metabolic process (GO:0046950)4.25102997
10aromatic amino acid family catabolic process (GO:0009074)4.17532656
11kynurenine metabolic process (GO:0070189)4.15362694
12omega-hydroxylase P450 pathway (GO:0097267)4.11129782
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.06969671
14glyoxylate metabolic process (GO:0046487)3.87667451
15ketone body metabolic process (GO:1902224)3.85411681
16epoxygenase P450 pathway (GO:0019373)3.85335096
17amino acid salvage (GO:0043102)3.72370297
18L-methionine salvage (GO:0071267)3.72370297
19L-methionine biosynthetic process (GO:0071265)3.72370297
20DNA double-strand break processing (GO:0000729)3.71769765
21amine catabolic process (GO:0009310)3.58881251
22cellular biogenic amine catabolic process (GO:0042402)3.58881251
23arginine catabolic process (GO:0006527)3.53578146
24drug metabolic process (GO:0017144)3.51065437
25signal peptide processing (GO:0006465)3.43604879
26S-adenosylmethionine metabolic process (GO:0046500)3.43546978
27detection of light stimulus involved in sensory perception (GO:0050962)3.41406354
28detection of light stimulus involved in visual perception (GO:0050908)3.41406354
29L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33975704
30aromatic amino acid family metabolic process (GO:0009072)3.31917074
31photoreceptor cell maintenance (GO:0045494)3.30534524
32piRNA metabolic process (GO:0034587)3.30497740
33response to pheromone (GO:0019236)3.27891996
34bile acid biosynthetic process (GO:0006699)3.27188531
35methionine biosynthetic process (GO:0009086)3.22312194
36indole-containing compound metabolic process (GO:0042430)3.22111641
37L-phenylalanine catabolic process (GO:0006559)3.19108570
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.19108570
39dopamine transport (GO:0015872)3.19034636
40negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18921978
41cellular response to sterol (GO:0036315)3.18120202
42benzene-containing compound metabolic process (GO:0042537)3.17530402
43neural tube formation (GO:0001841)3.17235847
44behavioral response to ethanol (GO:0048149)3.15115699
45behavioral response to nicotine (GO:0035095)3.13974567
46flavonoid metabolic process (GO:0009812)3.11415874
47alkaloid metabolic process (GO:0009820)3.10265838
48fucose catabolic process (GO:0019317)3.08527050
49L-fucose metabolic process (GO:0042354)3.08527050
50L-fucose catabolic process (GO:0042355)3.08527050
51response to nitrosative stress (GO:0051409)3.08007665
52regulation of triglyceride catabolic process (GO:0010896)3.05633263
53cellular glucuronidation (GO:0052695)3.03742772
54negative regulation of protein activation cascade (GO:2000258)3.02628792
55serine family amino acid catabolic process (GO:0009071)3.02323767
56protein K11-linked deubiquitination (GO:0035871)3.02298829
57regulation of hippo signaling (GO:0035330)3.01801980
58regulation of protein activation cascade (GO:2000257)2.94545146
59glucuronate metabolic process (GO:0019585)2.94209020
60uronic acid metabolic process (GO:0006063)2.94209020
61arginine metabolic process (GO:0006525)2.90919321
62methionine metabolic process (GO:0006555)2.90642745
63regulation of acrosome reaction (GO:0060046)2.89702901
64negative regulation of complement activation (GO:0045916)2.88521151
65retinal cone cell development (GO:0046549)2.87771553
66gamma-aminobutyric acid transport (GO:0015812)2.86371842
67cilium or flagellum-dependent cell motility (GO:0001539)2.86084334
68C4-dicarboxylate transport (GO:0015740)2.84934843
69complement activation, alternative pathway (GO:0006957)2.84556417
70regulation of complement activation (GO:0030449)2.83888997
71xenobiotic catabolic process (GO:0042178)2.82964239
72phenylpropanoid metabolic process (GO:0009698)2.81000687
73regulation of meiosis I (GO:0060631)2.80627911
74alpha-amino acid catabolic process (GO:1901606)2.79641058
75reflex (GO:0060004)2.79432741
76tachykinin receptor signaling pathway (GO:0007217)2.76652056
77UDP-N-acetylglucosamine metabolic process (GO:0006047)2.75449346
78aspartate family amino acid catabolic process (GO:0009068)2.73657468
79regulation of glucokinase activity (GO:0033131)2.72413785
80regulation of hexokinase activity (GO:1903299)2.72413785
81coenzyme catabolic process (GO:0009109)2.70779725
82prenylation (GO:0097354)2.67040845
83protein prenylation (GO:0018342)2.67040845
84pyrimidine nucleobase catabolic process (GO:0006208)2.65265526
85auditory receptor cell stereocilium organization (GO:0060088)2.64514858
86bile acid metabolic process (GO:0008206)2.63952259
87high-density lipoprotein particle remodeling (GO:0034375)2.63329867
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58206498
89imidazole-containing compound metabolic process (GO:0052803)2.57770158
90glycine metabolic process (GO:0006544)2.56114241
91reverse cholesterol transport (GO:0043691)2.55466678
92branched-chain amino acid catabolic process (GO:0009083)2.54296354
93axoneme assembly (GO:0035082)2.53856862
94dicarboxylic acid catabolic process (GO:0043649)2.52799110
95double-strand break repair via homologous recombination (GO:0000724)2.52190141
96recombinational repair (GO:0000725)2.51546029
97replication fork processing (GO:0031297)2.51509594
98inner ear receptor stereocilium organization (GO:0060122)2.50458404
99DNA methylation involved in gamete generation (GO:0043046)2.48815059
100regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47735297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.27781261
2ZNF274_21170338_ChIP-Seq_K562_Hela3.19895030
3VDR_22108803_ChIP-Seq_LS180_Human3.19344037
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80722877
5IGF1R_20145208_ChIP-Seq_DFB_Human2.78661754
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77616800
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71284468
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67636866
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.29566864
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29100565
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23026919
12TAF15_26573619_Chip-Seq_HEK293_Human2.22781489
13P300_19829295_ChIP-Seq_ESCs_Human2.19229030
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.17703017
15* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09889311
16FUS_26573619_Chip-Seq_HEK293_Human2.05744616
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.04062081
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98664658
19EWS_26573619_Chip-Seq_HEK293_Human1.96041376
20ER_23166858_ChIP-Seq_MCF-7_Human1.95188281
21BCAT_22108803_ChIP-Seq_LS180_Human1.92619429
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92393431
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.89025429
24STAT3_23295773_ChIP-Seq_U87_Human1.88193240
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80417791
26SMAD4_21799915_ChIP-Seq_A2780_Human1.80087596
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77727593
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74196100
29CBP_20019798_ChIP-Seq_JUKART_Human1.71220263
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71220263
31TCF4_23295773_ChIP-Seq_U87_Human1.71220074
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63770839
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61076194
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58824257
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.57984423
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54131037
37AR_25329375_ChIP-Seq_VCAP_Human1.53882429
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52222007
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.49906617
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49859596
41TCF4_22108803_ChIP-Seq_LS180_Human1.49078856
42EZH2_22144423_ChIP-Seq_EOC_Human1.48511359
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47134581
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46025104
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45131857
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.44045102
47* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43904032
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43370730
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43370730
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40701979
51NANOG_19829295_ChIP-Seq_ESCs_Human1.39002976
52SOX2_19829295_ChIP-Seq_ESCs_Human1.39002976
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37246058
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35626182
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34275989
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32095641
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.31628769
58RUNX2_22187159_ChIP-Seq_PCA_Human1.30242625
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29757632
60IRF1_19129219_ChIP-ChIP_H3396_Human1.27671939
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27570471
62TP53_22573176_ChIP-Seq_HFKS_Human1.27131614
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.25292371
64AR_21572438_ChIP-Seq_LNCaP_Human1.24745073
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23945653
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23576398
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22618662
68CDX2_22108803_ChIP-Seq_LS180_Human1.22409330
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.21670129
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.21630633
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21602137
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20339039
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18435430
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14764454
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.14764454
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13503441
77* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12961625
78P53_22387025_ChIP-Seq_ESCs_Mouse1.12937751
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11405892
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10839541
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.09307525
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09024150
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08507272
84TP53_16413492_ChIP-PET_HCT116_Human1.08027265
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07149650
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.06619598
87P300_18555785_Chip-Seq_ESCs_Mouse1.05859147
88AR_20517297_ChIP-Seq_VCAP_Human1.05784169
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.05072643
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03662762
91NCOR_22424771_ChIP-Seq_293T_Human1.01034264
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00994218
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.00828794
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99805876
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98963475
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98628563
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97694177
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97677429
99KDM2B_26808549_Chip-Seq_REH_Human0.97344905
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96449612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.22175391
2MP0005085_abnormal_gallbladder_physiolo2.90120786
3MP0005551_abnormal_eye_electrophysiolog2.69770050
4MP0003646_muscle_fatigue2.66285099
5MP0002138_abnormal_hepatobiliary_system2.65288145
6MP0000569_abnormal_digit_pigmentation2.63710636
7MP0008057_abnormal_DNA_replication2.63236579
8MP0004147_increased_porphyrin_level2.53911591
9MP0008877_abnormal_DNA_methylation2.50643337
10MP0008875_abnormal_xenobiotic_pharmacok2.49289199
11MP0002139_abnormal_hepatobiliary_system2.40428491
12MP0005360_urolithiasis2.31188340
13MP0005365_abnormal_bile_salt2.31109719
14MP0003252_abnormal_bile_duct2.31064127
15MP0001968_abnormal_touch/_nociception2.12443740
16MP0001501_abnormal_sleep_pattern2.07369728
17MP0002736_abnormal_nociception_after2.03822232
18MP0002102_abnormal_ear_morphology2.03491662
19MP0002876_abnormal_thyroid_physiology2.02837849
20MP0005253_abnormal_eye_physiology1.80741233
21MP0009046_muscle_twitch1.76822530
22MP0008872_abnormal_physiological_respon1.76678189
23MP0000372_irregular_coat_pigmentation1.76259824
24MP0009697_abnormal_copulation1.76200235
25MP0005646_abnormal_pituitary_gland1.62560457
26MP0003718_maternal_effect1.61006760
27MP0003950_abnormal_plasma_membrane1.59811194
28MP0006276_abnormal_autonomic_nervous1.59538373
29MP0001764_abnormal_homeostasis1.57749832
30MP0004043_abnormal_pH_regulation1.56699881
31MP0005645_abnormal_hypothalamus_physiol1.53843626
32MP0003136_yellow_coat_color1.52508491
33MP0002638_abnormal_pupillary_reflex1.51483852
34MP0010329_abnormal_lipoprotein_level1.50801414
35MP0002837_dystrophic_cardiac_calcinosis1.47622257
36MP0000427_abnormal_hair_cycle1.46025954
37MP0009745_abnormal_behavioral_response1.45876080
38MP0001984_abnormal_olfaction1.43080466
39MP0001986_abnormal_taste_sensitivity1.43004171
40MP0002938_white_spotting1.41909319
41MP0002735_abnormal_chemical_nociception1.40431197
42MP0005670_abnormal_white_adipose1.39915587
43MP0001486_abnormal_startle_reflex1.38123378
44MP0005167_abnormal_blood-brain_barrier1.34395086
45MP0003880_abnormal_central_pattern1.34349563
46MP0005395_other_phenotype1.33215913
47MP0002168_other_aberrant_phenotype1.32224932
48MP0003787_abnormal_imprinting1.29918055
49MP0006072_abnormal_retinal_apoptosis1.29740584
50MP0008058_abnormal_DNA_repair1.28567093
51MP0006292_abnormal_olfactory_placode1.28109617
52MP0005332_abnormal_amino_acid1.22771459
53MP0010386_abnormal_urinary_bladder1.21989221
54MP0002272_abnormal_nervous_system1.21152982
55MP0001485_abnormal_pinna_reflex1.20888398
56MP0003868_abnormal_feces_composition1.15611856
57MP0004924_abnormal_behavior1.11812447
58MP0005386_behavior/neurological_phenoty1.11812447
59MP0009780_abnormal_chondrocyte_physiolo1.11260145
60MP0001666_abnormal_nutrient_absorption1.04629851
61MP0008775_abnormal_heart_ventricle1.00988980
62MP0005266_abnormal_metabolism0.99574317
63MP0000383_abnormal_hair_follicle0.93781271
64MP0002733_abnormal_thermal_nociception0.93138546
65MP0005410_abnormal_fertilization0.92087979
66MP0003045_fibrosis0.89629588
67MP0001970_abnormal_pain_threshold0.88847210
68MP0004215_abnormal_myocardial_fiber0.88819867
69MP0005195_abnormal_posterior_eye0.88612572
70MP0005174_abnormal_tail_pigmentation0.86757358
71MP0000631_abnormal_neuroendocrine_gland0.86174994
72MP0005171_absent_coat_pigmentation0.86095287
73MP0002067_abnormal_sensory_capabilities0.85096639
74MP0002572_abnormal_emotion/affect_behav0.84065548
75MP0002229_neurodegeneration0.83857336
76MP0004142_abnormal_muscle_tone0.83278007
77MP0001929_abnormal_gametogenesis0.82883673
78MP0003698_abnormal_male_reproductive0.82136795
79MP0002090_abnormal_vision0.81587069
80MP0001324_abnormal_eye_pigmentation0.80955956
81MP0002557_abnormal_social/conspecific_i0.80798437
82MP0002928_abnormal_bile_duct0.80704144
83MP0010094_abnormal_chromosome_stability0.80318516
84MP0002064_seizures0.79148990
85MP0002118_abnormal_lipid_homeostasis0.78332020
86MP0003633_abnormal_nervous_system0.78254199
87MP0002254_reproductive_system_inflammat0.77194011
88MP0005187_abnormal_penis_morphology0.76719809
89MP0001529_abnormal_vocalization0.76135576
90MP0000230_abnormal_systemic_arterial0.75862503
91MP0005408_hypopigmentation0.75685879
92MP0010368_abnormal_lymphatic_system0.75361456
93MP0005379_endocrine/exocrine_gland_phen0.74148691
94MP0003011_delayed_dark_adaptation0.71904461
95MP0005647_abnormal_sex_gland0.71658561
96MP0003137_abnormal_impulse_conducting0.70327543
97MP0002234_abnormal_pharynx_morphology0.69823395
98MP0003635_abnormal_synaptic_transmissio0.68527135
99MP0000538_abnormal_urinary_bladder0.67812598
100MP0005376_homeostasis/metabolism_phenot0.67744792

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.36570284
2Pancreatic cysts (HP:0001737)4.01389723
3Congenital stationary night blindness (HP:0007642)3.51450590
4Pancreatic fibrosis (HP:0100732)3.47298426
5True hermaphroditism (HP:0010459)3.30897454
6Abnormality of midbrain morphology (HP:0002418)3.30195937
7Molar tooth sign on MRI (HP:0002419)3.30195937
8Birth length less than 3rd percentile (HP:0003561)3.28548366
9Gaze-evoked nystagmus (HP:0000640)3.18407417
10Fair hair (HP:0002286)3.13394240
11Attenuation of retinal blood vessels (HP:0007843)3.09200847
12Abnormality of the renal cortex (HP:0011035)3.07388916
13Prolonged partial thromboplastin time (HP:0003645)3.06579463
14Nephronophthisis (HP:0000090)3.04563483
15Chronic hepatic failure (HP:0100626)3.00096766
16Abnormality of the renal medulla (HP:0100957)2.82820051
17Medial flaring of the eyebrow (HP:0010747)2.81975648
18Hypobetalipoproteinemia (HP:0003563)2.75568163
19Volvulus (HP:0002580)2.54195419
20Absent speech (HP:0001344)2.53126914
21Type II lissencephaly (HP:0007260)2.52922616
22Abolished electroretinogram (ERG) (HP:0000550)2.49467299
23Cystic liver disease (HP:0006706)2.48146207
24Bile duct proliferation (HP:0001408)2.45528012
25Abnormal biliary tract physiology (HP:0012439)2.45528012
26Keratoconus (HP:0000563)2.44235472
27Increased corneal curvature (HP:0100692)2.44235472
28Inability to walk (HP:0002540)2.44189021
29Intestinal atresia (HP:0011100)2.40644291
30Pendular nystagmus (HP:0012043)2.37552896
31Generalized hypopigmentation of hair (HP:0011358)2.36907489
32Thyroid-stimulating hormone excess (HP:0002925)2.33452421
33Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31982833
34Hypothermia (HP:0002045)2.31849767
35Tubular atrophy (HP:0000092)2.31419992
36Protruding tongue (HP:0010808)2.30947525
37Congenital sensorineural hearing impairment (HP:0008527)2.30802301
38Decreased central vision (HP:0007663)2.30493396
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.22602659
40Congenital primary aphakia (HP:0007707)2.21192666
41Hyperglycinuria (HP:0003108)2.21071729
42Gait imbalance (HP:0002141)2.20274276
43Bony spicule pigmentary retinopathy (HP:0007737)2.19344038
44Progressive inability to walk (HP:0002505)2.17971506
45Renal cortical cysts (HP:0000803)2.17759666
46Febrile seizures (HP:0002373)2.16809636
47Lissencephaly (HP:0001339)2.14566002
48Ketosis (HP:0001946)2.11566487
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.11358316
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08014154
51Abnormality of glycine metabolism (HP:0010895)2.07998261
52Abnormality of serine family amino acid metabolism (HP:0010894)2.07998261
53Complement deficiency (HP:0004431)2.07633529
54Stomach cancer (HP:0012126)2.06766563
55Intrahepatic cholestasis (HP:0001406)2.04865915
56Ketoacidosis (HP:0001993)2.02191131
57Tubulointerstitial nephritis (HP:0001970)2.02151563
58Large for gestational age (HP:0001520)2.00738399
59Abnormality of the labia minora (HP:0012880)2.00678793
60Congenital hepatic fibrosis (HP:0002612)2.00116567
61Hyperglycinemia (HP:0002154)1.97938670
62Hyperlipoproteinemia (HP:0010980)1.97393334
63Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96133698
64Genital tract atresia (HP:0001827)1.96041749
65Widely spaced teeth (HP:0000687)1.95380686
66Nephrogenic diabetes insipidus (HP:0009806)1.94481978
67Optic nerve hypoplasia (HP:0000609)1.94259685
68Focal motor seizures (HP:0011153)1.91133937
69Focal seizures (HP:0007359)1.88942179
70Abnormality of alanine metabolism (HP:0010916)1.88130840
71Hyperalaninemia (HP:0003348)1.88130840
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88130840
73Cerebellar dysplasia (HP:0007033)1.87590798
74Conjugated hyperbilirubinemia (HP:0002908)1.87224722
75Abnormality of macular pigmentation (HP:0008002)1.86136470
76Progressive cerebellar ataxia (HP:0002073)1.84159160
77Vaginal atresia (HP:0000148)1.81754470
78Furrowed tongue (HP:0000221)1.80878615
79Sclerocornea (HP:0000647)1.80299511
80Broad-based gait (HP:0002136)1.79539724
81Abnormality of methionine metabolism (HP:0010901)1.79469078
82Dialeptic seizures (HP:0011146)1.78740348
83Postaxial foot polydactyly (HP:0001830)1.78415067
84Abnormality of pyrimidine metabolism (HP:0004353)1.77918079
85Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77047499
86Retinal dysplasia (HP:0007973)1.74974569
87Hypoplasia of the pons (HP:0012110)1.74361510
88Patellar aplasia (HP:0006443)1.73820342
89Pancreatic islet-cell hyperplasia (HP:0004510)1.73188833
90Abnormality of the pons (HP:0007361)1.73029890
91Proximal tubulopathy (HP:0000114)1.72770050
92Epidermoid cyst (HP:0200040)1.72208373
93Genetic anticipation (HP:0003743)1.72078721
94Methylmalonic aciduria (HP:0012120)1.70729123
95Central scotoma (HP:0000603)1.70537208
96Thyroiditis (HP:0100646)1.69816674
97Abnormality of the ileum (HP:0001549)1.69801761
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.69201333
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68685744
100Tubulointerstitial abnormality (HP:0001969)1.68526924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.58753996
2ACVR1B3.79423784
3BMPR1B3.69409558
4MAP4K23.08040839
5CASK2.98462840
6ADRBK22.63569586
7WNK32.44770241
8NUAK12.27939306
9TRIM282.23251866
10ZAK2.06675231
11GRK11.94904978
12STK38L1.78849365
13INSRR1.78826204
14MAPK131.77452870
15DAPK21.68868959
16MKNK21.58645064
17TNIK1.52099334
18EIF2AK31.51896003
19PINK11.49439635
20TGFBR11.43746887
21PIK3CG1.42409469
22BRSK21.40838452
23TAOK31.39311867
24LATS11.27549398
25STK391.19517612
26NTRK31.16225325
27MAP3K41.16217480
28BCR1.14781527
29ADRBK11.14554040
30PAK31.11623615
31MARK11.10975653
32PLK21.10018194
33AKT31.08310650
34OXSR11.06825564
35ERBB31.00029389
36MST40.96990022
37EPHA40.96973061
38STK30.92539369
39MKNK10.92439068
40PRKCE0.90298756
41FGFR20.88747895
42PRKCG0.85484899
43BCKDK0.84552809
44PTK2B0.83117428
45FER0.79232042
46TEC0.76672283
47PNCK0.76495638
48CAMKK20.74826022
49CSNK1G10.72488804
50PLK40.67508845
51CCNB10.67021756
52PKN10.66359803
53PLK30.65922005
54WEE10.63506188
55WNK40.61786438
56NME10.60692206
57PRKAA20.59425733
58CAMK2A0.58048177
59CSNK1G20.57516359
60PDK20.57027777
61CSNK1A1L0.56520655
62CSNK1G30.54652204
63NLK0.52654374
64MELK0.51372469
65MAP2K70.49955896
66IRAK10.49170516
67TNK20.47589527
68PIK3CA0.47584069
69MAPKAPK50.47101815
70CAMK1G0.45711417
71PRKAA10.41439004
72PLK10.40379483
73DYRK20.39416964
74CSNK1A10.38387188
75TIE10.38152267
76ATM0.38146007
77MAPKAPK30.37023089
78VRK10.36762075
79CSNK1D0.35402291
80PRKACA0.35252242
81EIF2AK10.34671259
82CAMK10.34092574
83IGF1R0.33179550
84MAP2K60.33170189
85ITK0.32811660
86MAP2K10.31963592
87BRD40.31577347
88MARK30.30533126
89PRKACB0.29728640
90FLT30.29373697
91PRKG10.29225574
92ATR0.28687765
93OBSCN0.27949012
94PRKACG0.27941759
95GRK50.27074541
96STK380.25871578
97SGK20.25291807
98MUSK0.24284957
99PRKCB0.24003443
100PRKCA0.23898072

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.21419652
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.98643312
3Caffeine metabolism_Homo sapiens_hsa002322.77535208
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.71108897
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62263455
6Retinol metabolism_Homo sapiens_hsa008302.60357402
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56203339
8Tryptophan metabolism_Homo sapiens_hsa003802.48254474
9Linoleic acid metabolism_Homo sapiens_hsa005912.46361402
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.35878016
11Chemical carcinogenesis_Homo sapiens_hsa052042.25610126
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20978569
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17554947
14Phototransduction_Homo sapiens_hsa047442.05161747
15ABC transporters_Homo sapiens_hsa020102.04813990
16Complement and coagulation cascades_Homo sapiens_hsa046102.03284385
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00249070
18Propanoate metabolism_Homo sapiens_hsa006401.95491198
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89378344
20Fatty acid degradation_Homo sapiens_hsa000711.88348423
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78579633
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64520620
23Histidine metabolism_Homo sapiens_hsa003401.63580807
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61189821
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57572521
26beta-Alanine metabolism_Homo sapiens_hsa004101.55507756
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.48055651
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46596256
29Nitrogen metabolism_Homo sapiens_hsa009101.45508725
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39233519
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.38795238
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37602595
33Peroxisome_Homo sapiens_hsa041461.37414178
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31264534
35Homologous recombination_Homo sapiens_hsa034401.31101883
36Fanconi anemia pathway_Homo sapiens_hsa034601.28262617
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27721187
38Nicotine addiction_Homo sapiens_hsa050331.25104093
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22408751
40Arginine biosynthesis_Homo sapiens_hsa002201.19287423
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.17814243
42Selenocompound metabolism_Homo sapiens_hsa004501.17341114
43Arachidonic acid metabolism_Homo sapiens_hsa005901.17209051
44One carbon pool by folate_Homo sapiens_hsa006701.15463635
45Tyrosine metabolism_Homo sapiens_hsa003501.11507617
46Non-homologous end-joining_Homo sapiens_hsa034501.11385057
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.10434017
48Ether lipid metabolism_Homo sapiens_hsa005651.08772970
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05225411
50Glycerolipid metabolism_Homo sapiens_hsa005610.97185989
51Protein export_Homo sapiens_hsa030600.96774493
52Lysine degradation_Homo sapiens_hsa003100.95028801
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91466025
54Fatty acid metabolism_Homo sapiens_hsa012120.86110876
55Starch and sucrose metabolism_Homo sapiens_hsa005000.86103644
56Bile secretion_Homo sapiens_hsa049760.85880680
57Basal transcription factors_Homo sapiens_hsa030220.84540625
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83251311
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82594380
60Taste transduction_Homo sapiens_hsa047420.81920349
61Olfactory transduction_Homo sapiens_hsa047400.76819169
62Serotonergic synapse_Homo sapiens_hsa047260.73825175
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73286488
64Fat digestion and absorption_Homo sapiens_hsa049750.70200091
65Arginine and proline metabolism_Homo sapiens_hsa003300.69665497
66PPAR signaling pathway_Homo sapiens_hsa033200.67644635
67Ovarian steroidogenesis_Homo sapiens_hsa049130.65768323
68Metabolic pathways_Homo sapiens_hsa011000.64035934
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56537529
70Morphine addiction_Homo sapiens_hsa050320.55892925
71GABAergic synapse_Homo sapiens_hsa047270.55182970
72Fatty acid biosynthesis_Homo sapiens_hsa000610.54874901
73Pyruvate metabolism_Homo sapiens_hsa006200.53993150
74RNA polymerase_Homo sapiens_hsa030200.53702621
75Circadian rhythm_Homo sapiens_hsa047100.52689694
76Circadian entrainment_Homo sapiens_hsa047130.51169046
77Fatty acid elongation_Homo sapiens_hsa000620.47791161
78Phenylalanine metabolism_Homo sapiens_hsa003600.47683805
79Glutamatergic synapse_Homo sapiens_hsa047240.46746160
80Salivary secretion_Homo sapiens_hsa049700.45240671
81Calcium signaling pathway_Homo sapiens_hsa040200.44914471
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43326093
83Sphingolipid metabolism_Homo sapiens_hsa006000.42638327
84Insulin secretion_Homo sapiens_hsa049110.41934932
85Vitamin B6 metabolism_Homo sapiens_hsa007500.41351047
86Dorso-ventral axis formation_Homo sapiens_hsa043200.41200823
87RNA degradation_Homo sapiens_hsa030180.40934375
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40825414
89Sulfur metabolism_Homo sapiens_hsa009200.40568128
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40076031
91Steroid biosynthesis_Homo sapiens_hsa001000.36833591
92Regulation of autophagy_Homo sapiens_hsa041400.35518747
93Purine metabolism_Homo sapiens_hsa002300.32241653
94Mineral absorption_Homo sapiens_hsa049780.30552718
95Vitamin digestion and absorption_Homo sapiens_hsa049770.29371514
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.28874096
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27601005
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.27188803
99Glutathione metabolism_Homo sapiens_hsa004800.26199163
100Long-term depression_Homo sapiens_hsa047300.18424354

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