SLC22A18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.27452763
2L-phenylalanine catabolic process (GO:0006559)7.27452763
3L-phenylalanine metabolic process (GO:0006558)7.08932228
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.08932228
5aromatic amino acid family catabolic process (GO:0009074)6.78223453
6glyoxylate metabolic process (GO:0046487)6.48384215
7tryptophan catabolic process (GO:0006569)6.30687502
8indole-containing compound catabolic process (GO:0042436)6.30687502
9indolalkylamine catabolic process (GO:0046218)6.30687502
10cysteine metabolic process (GO:0006534)6.28858383
11lysine catabolic process (GO:0006554)6.11467501
12lysine metabolic process (GO:0006553)6.11467501
13tryptophan metabolic process (GO:0006568)5.92839170
14kynurenine metabolic process (GO:0070189)5.83364108
15urate metabolic process (GO:0046415)5.76645352
16sulfur amino acid catabolic process (GO:0000098)5.38748731
17serine family amino acid catabolic process (GO:0009071)5.36407165
18bile acid biosynthetic process (GO:0006699)5.34033645
19* drug transmembrane transport (GO:0006855)5.33963101
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.27528406
21drug catabolic process (GO:0042737)5.16548449
22homocysteine metabolic process (GO:0050667)5.14026716
23aromatic amino acid family metabolic process (GO:0009072)4.95447379
24amino-acid betaine metabolic process (GO:0006577)4.93383187
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.92238157
26urea metabolic process (GO:0019627)4.89938937
27urea cycle (GO:0000050)4.89938937
28epoxygenase P450 pathway (GO:0019373)4.76533316
29alpha-linolenic acid metabolic process (GO:0036109)4.75756170
30exogenous drug catabolic process (GO:0042738)4.73301147
31cellular ketone body metabolic process (GO:0046950)4.71168222
32alpha-amino acid catabolic process (GO:1901606)4.66000356
33serine family amino acid metabolic process (GO:0009069)4.65078250
34short-chain fatty acid metabolic process (GO:0046459)4.58429796
35* drug transport (GO:0015893)4.57580160
36nitrogen cycle metabolic process (GO:0071941)4.57155444
37bile acid metabolic process (GO:0008206)4.54596952
38cellular modified amino acid catabolic process (GO:0042219)4.54305046
39cellular glucuronidation (GO:0052695)4.50019754
40glutamate metabolic process (GO:0006536)4.46917633
41indolalkylamine metabolic process (GO:0006586)4.44490626
42cellular amino acid catabolic process (GO:0009063)4.43545014
43tyrosine metabolic process (GO:0006570)4.36827560
44benzene-containing compound metabolic process (GO:0042537)4.36587609
45amine catabolic process (GO:0009310)4.30187839
46cellular biogenic amine catabolic process (GO:0042402)4.30187839
47protein carboxylation (GO:0018214)4.29903696
48peptidyl-glutamic acid carboxylation (GO:0017187)4.29903696
49high-density lipoprotein particle remodeling (GO:0034375)4.29898165
50aspartate family amino acid catabolic process (GO:0009068)4.29889581
51serine family amino acid biosynthetic process (GO:0009070)4.29478335
52negative regulation of fibrinolysis (GO:0051918)4.27232223
53angiotensin maturation (GO:0002003)4.24402588
54uronic acid metabolic process (GO:0006063)4.22763277
55glucuronate metabolic process (GO:0019585)4.22763277
56regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.22267871
57complement activation, alternative pathway (GO:0006957)4.10759605
58aldehyde catabolic process (GO:0046185)4.09570365
59response to mercury ion (GO:0046689)4.08119554
60ketone body metabolic process (GO:1902224)4.07773977
61regulation of fibrinolysis (GO:0051917)4.07304296
62acetyl-CoA metabolic process (GO:0006084)4.04397579
63negative regulation of sterol transport (GO:0032372)4.03889195
64negative regulation of cholesterol transport (GO:0032375)4.03889195
652-oxoglutarate metabolic process (GO:0006103)4.03698922
66regulation of protein activation cascade (GO:2000257)4.03174822
67ethanol oxidation (GO:0006069)4.01911237
68glycine metabolic process (GO:0006544)4.01177563
69coenzyme catabolic process (GO:0009109)3.99578867
70carboxylic acid catabolic process (GO:0046395)3.95458555
71organic acid catabolic process (GO:0016054)3.95458555
72flavonoid metabolic process (GO:0009812)3.94950739
73fatty acid beta-oxidation (GO:0006635)3.94685083
74regulation of triglyceride catabolic process (GO:0010896)3.93051863
75fatty acid oxidation (GO:0019395)3.89480777
76carnitine metabolic process (GO:0009437)3.87943977
77bile acid and bile salt transport (GO:0015721)3.86896896
78fat-soluble vitamin biosynthetic process (GO:0042362)3.84986741
79dicarboxylic acid biosynthetic process (GO:0043650)3.84709592
80regulation of cholesterol esterification (GO:0010872)3.83920347
81valine metabolic process (GO:0006573)3.83032704
82lipid oxidation (GO:0034440)3.81903296
83acylglycerol homeostasis (GO:0055090)3.80295402
84triglyceride homeostasis (GO:0070328)3.80295402
85regulation of complement activation (GO:0030449)3.77581750
86reverse cholesterol transport (GO:0043691)3.74033187
87regulation of cholesterol homeostasis (GO:2000188)3.72838644
88drug metabolic process (GO:0017144)3.72815107
89positive regulation of triglyceride lipase activity (GO:0061365)3.72704906
90positive regulation of lipoprotein lipase activity (GO:0051006)3.72704906
91monocarboxylic acid catabolic process (GO:0072329)3.71945482
92plasma lipoprotein particle remodeling (GO:0034369)3.70143706
93protein-lipid complex remodeling (GO:0034368)3.70143706
94macromolecular complex remodeling (GO:0034367)3.70143706
95phosphate ion transport (GO:0006817)3.69072012
96arginine metabolic process (GO:0006525)3.68633003
97response to nitrosative stress (GO:0051409)3.65418548
98fatty acid catabolic process (GO:0009062)3.64943645
99branched-chain amino acid metabolic process (GO:0009081)3.62063476
100intestinal absorption (GO:0050892)3.60590817
101phospholipid efflux (GO:0033700)3.53858686
102phosphate ion transmembrane transport (GO:0035435)3.51441736
103regulation of bile acid biosynthetic process (GO:0070857)3.48593564
104branched-chain amino acid catabolic process (GO:0009083)3.45755214
105imidazole-containing compound metabolic process (GO:0052803)3.44725119
106pyridine nucleotide biosynthetic process (GO:0019363)3.43233998
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.43233998
108alkaloid metabolic process (GO:0009820)3.42096451
109plasma lipoprotein particle assembly (GO:0034377)3.23110002
110very-low-density lipoprotein particle assembly (GO:0034379)3.20466907
111diacylglycerol metabolic process (GO:0046339)3.15638750
112omega-hydroxylase P450 pathway (GO:0097267)3.10072795
113cholesterol efflux (GO:0033344)3.06116972
114positive regulation of triglyceride metabolic process (GO:0090208)3.05961219
115hormone catabolic process (GO:0042447)3.03249080
116positive regulation of lipid catabolic process (GO:0050996)3.01698353
117positive regulation of fatty acid biosynthetic process (GO:0045723)2.95672241
118acute-phase response (GO:0006953)2.93164055
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90051796
120peptide catabolic process (GO:0043171)2.89264617
121plasma lipoprotein particle organization (GO:0071827)2.87709358
122regulation of guanylate cyclase activity (GO:0031282)2.86784598
123protein-lipid complex assembly (GO:0065005)2.85662208
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84389456
125antigen processing and presentation of endogenous antigen (GO:0019883)2.80692918
126glycosphingolipid catabolic process (GO:0046479)2.79138965
127complement activation, classical pathway (GO:0006958)2.73854444
128protein-lipid complex subunit organization (GO:0071825)2.69428783
129complement activation (GO:0006956)2.69265488
130lipoprotein metabolic process (GO:0042157)2.67308965
131regulation of systemic arterial blood pressure by hormone (GO:0001990)2.65293755
132regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.65293755
133endocrine process (GO:0050886)2.65293755
134arginine catabolic process (GO:0006527)2.64991088
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64952043
136ethanol metabolic process (GO:0006067)2.64585028
137virion attachment to host cell (GO:0019062)2.64327157
138adhesion of symbiont to host cell (GO:0044650)2.64327157
139phenylpropanoid metabolic process (GO:0009698)2.60516958
140fructose metabolic process (GO:0006000)2.59935214
141glycolipid catabolic process (GO:0019377)2.59246832
142protein activation cascade (GO:0072376)2.58163685
143low-density lipoprotein particle remodeling (GO:0034374)2.57799259
144regulation of triglyceride metabolic process (GO:0090207)2.56927078
145glutathione biosynthetic process (GO:0006750)2.56561532
146plasma lipoprotein particle clearance (GO:0034381)2.54276509
147adhesion of symbiont to host (GO:0044406)2.53061569
148maintenance of gastrointestinal epithelium (GO:0030277)2.52217219
149fibrinolysis (GO:0042730)2.51526260
150mannose metabolic process (GO:0006013)2.50972341
151intestinal cholesterol absorption (GO:0030299)2.47602016
152oligosaccharide catabolic process (GO:0009313)2.44411569
153nonribosomal peptide biosynthetic process (GO:0019184)2.43451568
154amyloid precursor protein catabolic process (GO:0042987)2.42496911
155cholesterol homeostasis (GO:0042632)2.42384641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.02352686
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.92425362
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.12558186
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.12430055
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.07010478
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.65506926
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.43173213
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65496975
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.64498891
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16713114
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.47346969
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.40891111
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31431585
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.11586983
15* BCL6_27268052_Chip-Seq_Bcells_Human2.00237104
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1257427
17IRF8_21731497_ChIP-ChIP_J774_Mouse1.96654156
18BCOR_27268052_Chip-Seq_Bcells_Human1.83496526
19VDR_21846776_ChIP-Seq_THP-1_Human1.76421897
20CLOCK_20551151_ChIP-Seq_293T_Human1.67947025
21* P68_20966046_ChIP-Seq_HELA_Human1.67450809
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64441101
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.60913185
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58721991
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.57474315
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.56679469
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56016293
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55527521
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54647082
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.52316297
31E2F1_20622854_ChIP-Seq_HELA_Human1.51824568
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49945154
33SA1_27219007_Chip-Seq_Bcells_Human1.49356574
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48323782
35VDR_24763502_ChIP-Seq_THP-1_Human1.43514667
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39491988
37PHF8_20622854_ChIP-Seq_HELA_Human1.38444515
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38391779
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.34222226
40SMC4_20622854_ChIP-Seq_HELA_Human1.33156139
41* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32332323
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.31397917
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.29698196
44* CTCF_20526341_ChIP-Seq_ESCs_Human1.29508034
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26788495
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26621858
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26027047
48CTCF_27219007_Chip-Seq_Bcells_Human1.25161853
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25027973
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24355928
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23727214
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23266010
53GATA4_25053715_ChIP-Seq_YYC3_Human1.22361328
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22078589
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.21555299
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20400622
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.18363915
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18129584
59P300_27268052_Chip-Seq_Bcells_Human1.17445459
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16082426
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15614831
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14995323
63* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14556855
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14422241
65* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14363266
66GATA1_22025678_ChIP-Seq_K562_Human1.13215373
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.12691522
68TP63_22573176_ChIP-Seq_HFKS_Human1.11151409
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11083858
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10759572
71RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10174366
72STAT1_20625510_ChIP-Seq_HELA_Human1.10114376
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08857241
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08655851
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.08225931
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07929904
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07686127
78ERA_21632823_ChIP-Seq_H3396_Human1.06096160
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05799586
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04068074
81* RAC3_21632823_ChIP-Seq_H3396_Human1.04002695
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02683323
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02578501
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01002251
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99565565
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99360148
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99127693
88HTT_18923047_ChIP-ChIP_STHdh_Human0.98943980
89* SPI1_23127762_ChIP-Seq_K562_Human0.98483883
90RUNX1_22412390_ChIP-Seq_EML_Mouse0.98177852
91CREB1_26743006_Chip-Seq_LNCaP_Human0.97933567
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97787075
93NANOG_20526341_ChIP-Seq_ESCs_Human0.97240570
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97204567
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96984670
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90783924
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87243658
98LXR_22292898_ChIP-Seq_THP-1_Human0.85161962
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80955171
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80438378
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80389070
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77078464
103GATA6_25053715_ChIP-Seq_YYC3_Human0.77070754
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76803354
105* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74783637
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74411156
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74322486
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73459828
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73431928
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72833439
111EGR1_19032775_ChIP-ChIP_M12_Human0.71910767
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71773937
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.69358921
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.68349287
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67299828
116ZNF263_19887448_ChIP-Seq_K562_Human0.67076304
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65236513
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65236513
119CEBPB_22108803_ChIP-Seq_LS180_Human0.64934920
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63816441
121* SOX2_20726797_ChIP-Seq_SW620_Human0.63477014
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.63445938
123AR_20517297_ChIP-Seq_VCAP_Human0.62518016
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.62467880
125MYC_19915707_ChIP-ChIP_AK7_Human0.61939179
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.61737196
127* RACK7_27058665_Chip-Seq_MCF-7_Human0.60732208
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60374903
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.57115169
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57080892
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56849526
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.56783984
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.56134534
134ESET_19884257_ChIP-Seq_ESCs_Mouse0.56020988
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55711379
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55458618
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.55414053
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55279305
139AR_21909140_ChIP-Seq_LNCAP_Human0.55005806
140STAT1_17558387_ChIP-Seq_HELA_Human0.53431074
141TAF2_19829295_ChIP-Seq_ESCs_Human0.53171105
142GATA2_19941826_ChIP-Seq_K562_Human0.51961423
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.50907697
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50776237
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49995106
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.48436868
147* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.47838317
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.46902959
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46439385
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.46347194
151P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.46321755
152CBP_21632823_ChIP-Seq_H3396_Human0.45842151
153CDX2_22108803_ChIP-Seq_LS180_Human0.45538380
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.45109350
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44707514
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.44474431
157P53_21459846_ChIP-Seq_SAOS-2_Human0.44269114
158ESR1_20079471_ChIP-ChIP_T-47D_Human0.43635647
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42802440
160PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42790225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.28628650
2MP0002139_abnormal_hepatobiliary_system7.82621345
3MP0005085_abnormal_gallbladder_physiolo5.54759938
4MP0005365_abnormal_bile_salt5.43899658
5MP0008875_abnormal_xenobiotic_pharmacok5.02910501
6MP0003806_abnormal_nucleotide_metabolis3.68432104
7MP0003252_abnormal_bile_duct3.67283981
8MP0005332_abnormal_amino_acid3.65052038
9MP0003195_calcinosis3.28118091
10MP0004019_abnormal_vitamin_homeostasis3.20283782
11MP0010329_abnormal_lipoprotein_level2.98363861
12MP0002138_abnormal_hepatobiliary_system2.63775404
13MP0009840_abnormal_foam_cell2.54948988
14MP0001666_abnormal_nutrient_absorption2.50143519
15MP0005083_abnormal_biliary_tract2.31932674
16MP0003172_abnormal_lysosome_physiology2.26443329
17MP0009643_abnormal_urine_homeostasis2.25778431
18MP0004043_abnormal_pH_regulation2.17769378
19MP0003191_abnormal_cellular_cholesterol2.17181123
20MP0010155_abnormal_intestine_physiology1.92692387
21MP0003183_abnormal_peptide_metabolism1.89395077
22MP0002118_abnormal_lipid_homeostasis1.87619708
23MP0005319_abnormal_enzyme/_coenzyme1.86122159
24MP0000609_abnormal_liver_physiology1.84579981
25MP0009785_altered_susceptibility_to1.80033410
26MP0005636_abnormal_mineral_homeostasis1.76046231
27MP0005584_abnormal_enzyme/coenzyme_acti1.70070940
28MP0005025_abnormal_response_to1.65736883
29MP0001764_abnormal_homeostasis1.64207782
30MP0003186_abnormal_redox_activity1.63884937
31MP0002148_abnormal_hypersensitivity_rea1.60324209
32MP0003303_peritoneal_inflammation1.55286063
33MP0002419_abnormal_innate_immunity1.55187171
34MP0005451_abnormal_body_composition1.54357573
35MP0001873_stomach_inflammation1.51715242
36MP0001835_abnormal_antigen_presentation1.49043361
37MP0003868_abnormal_feces_composition1.48741237
38MP0005387_immune_system_phenotype1.48705186
39MP0001790_abnormal_immune_system1.48705186
40MP0001756_abnormal_urination1.48323843
41MP0000685_abnormal_immune_system1.38396151
42MP0003866_abnormal_defecation1.35855091
43MP0001765_abnormal_ion_homeostasis1.35003645
44MP0003879_abnormal_hair_cell1.34716661
45MP0002136_abnormal_kidney_physiology1.31330871
46MP0000678_abnormal_parathyroid_gland1.30846103
47MP0001533_abnormal_skeleton_physiology1.27147625
48MP0005000_abnormal_immune_tolerance1.23448618
49MP0002132_abnormal_respiratory_system1.21052468
50MP0005671_abnormal_response_to1.21013949
51MP0001800_abnormal_humoral_immune1.18319444
52MP0002723_abnormal_immune_serum1.14750904
53MP0002876_abnormal_thyroid_physiology1.08810413
54MP0004947_skin_inflammation1.07412780
55MP0002452_abnormal_antigen_presenting1.06640788
56MP0000598_abnormal_liver_morphology1.06204472
57MP0009333_abnormal_splenocyte_physiolog1.06157877
58MP0009764_decreased_sensitivity_to1.05889759
59MP0006036_abnormal_mitochondrial_physio1.04894230
60MP0005084_abnormal_gallbladder_morpholo1.03971173
61MP0003705_abnormal_hypodermis_morpholog1.03160726
62MP0005310_abnormal_salivary_gland1.02442461
63MP0004858_abnormal_nervous_system1.02249909
64MP0005410_abnormal_fertilization0.95576699
65MP0009642_abnormal_blood_homeostasis0.91927951
66MP0009697_abnormal_copulation0.91793868
67MP0005670_abnormal_white_adipose0.91651329
68MP0003656_abnormal_erythrocyte_physiolo0.91596770
69MP0001819_abnormal_immune_cell0.91234338
70MP0002420_abnormal_adaptive_immunity0.89658345
71MP0008469_abnormal_protein_level0.89320310
72MP0005647_abnormal_sex_gland0.88734430
73MP0002998_abnormal_bone_remodeling0.87803810
74MP0005058_abnormal_lysosome_morphology0.86042918
75MP0001664_abnormal_digestion0.85248213
76MP0004510_myositis0.84338738
77MP0003011_delayed_dark_adaptation0.83849332
78MP0005381_digestive/alimentary_phenotyp0.83821492
79MP0000604_amyloidosis0.82315945
80MP0005408_hypopigmentation0.82016791
81MP0005535_abnormal_body_temperature0.80133942
82MP0009763_increased_sensitivity_to0.79354378
83MP0008260_abnormal_autophagy0.79049630
84MP0005220_abnormal_exocrine_pancreas0.77939580
85MP0000538_abnormal_urinary_bladder0.73483924
86MP0002078_abnormal_glucose_homeostasis0.71571660
87MP0002254_reproductive_system_inflammat0.71387445
88MP0009765_abnormal_xenobiotic_induced0.71078195
89MP0002928_abnormal_bile_duct0.71002485
90MP0005376_homeostasis/metabolism_phenot0.70564672
91MP0000249_abnormal_blood_vessel0.69603519
92MP0002933_joint_inflammation0.68940210
93MP0000858_altered_metastatic_potential0.67094364
94MP0000015_abnormal_ear_pigmentation0.66160523
95MP0005257_abnormal_intraocular_pressure0.65412511
96MP0001661_extended_life_span0.65050994
97MP0000343_altered_response_to0.63886158
98MP0004264_abnormal_extraembryonic_tissu0.63523565
99MP0003638_abnormal_response/metabolism_0.63281393
100MP0000230_abnormal_systemic_arterial0.59940166
101MP0003878_abnormal_ear_physiology0.59654911
102MP0005377_hearing/vestibular/ear_phenot0.59654911
103MP0009053_abnormal_anal_canal0.59488305
104MP0002971_abnormal_brown_adipose0.58091480
105MP0005266_abnormal_metabolism0.57801163
106MP0003300_gastrointestinal_ulcer0.56249673
107MP0005666_abnormal_adipose_tissue0.55428214
108MP0002168_other_aberrant_phenotype0.54916330
109MP0005334_abnormal_fat_pad0.54643355
110MP0005395_other_phenotype0.54207554
111MP0003329_amyloid_beta_deposits0.53375561
112MP0002135_abnormal_kidney_morphology0.53006503
113MP0002796_impaired_skin_barrier0.52718867
114MP0006035_abnormal_mitochondrial_morpho0.52622003
115MP0010234_abnormal_vibrissa_follicle0.52153073
116MP0010368_abnormal_lymphatic_system0.51129810
117MP0003724_increased_susceptibility_to0.49711298
118MP0004147_increased_porphyrin_level0.48661833
119MP0008961_abnormal_basal_metabolism0.46400808
120MP0003953_abnormal_hormone_level0.45038030
121MP0004782_abnormal_surfactant_physiolog0.43393143
122MP0004130_abnormal_muscle_cell0.41772503
123MP0003690_abnormal_glial_cell0.41594781
124MP0008872_abnormal_physiological_respon0.41455245
125MP0005166_decreased_susceptibility_to0.41260909
126MP0003075_altered_response_to0.40970861
127MP0008873_increased_physiological_sensi0.38162139
128MP0008874_decreased_physiological_sensi0.36968057
129MP0001845_abnormal_inflammatory_respons0.36848536
130MP0005448_abnormal_energy_balance0.36290458
131MP0005464_abnormal_platelet_physiology0.36170724
132MP0001958_emphysema0.33977036
133MP0003959_abnormal_lean_body0.33190086
134MP0003718_maternal_effect0.32205602
135MP0005167_abnormal_blood-brain_barrier0.31026562
136MP0006082_CNS_inflammation0.30330666
137MP0009115_abnormal_fat_cell0.29611851
138MP0009672_abnormal_birth_weight0.28857855
139MP0003436_decreased_susceptibility_to0.28494276
140MP0001663_abnormal_digestive_system0.27933756
141MP0002822_catalepsy0.27138285

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.33820995
2Intrahepatic cholestasis (HP:0001406)5.70412491
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.30044239
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.23117073
5Deep venous thrombosis (HP:0002625)5.20416292
6Xanthomatosis (HP:0000991)5.08564062
7Hyperglycinuria (HP:0003108)5.04597312
8Gout (HP:0001997)4.86280523
9Abnormality of serine family amino acid metabolism (HP:0010894)4.59900671
10Abnormality of glycine metabolism (HP:0010895)4.59900671
11Ketosis (HP:0001946)4.50727939
12Hypobetalipoproteinemia (HP:0003563)4.49999367
13Hyperammonemia (HP:0001987)4.41249312
14Prolonged partial thromboplastin time (HP:0003645)4.39076650
15Hyperglycinemia (HP:0002154)4.35620473
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.25451681
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.04202110
18Abnormality of purine metabolism (HP:0004352)4.01631803
19Glomerulonephritis (HP:0000099)3.94504202
20Hyperlipoproteinemia (HP:0010980)3.89747566
21Ketoacidosis (HP:0001993)3.79857226
22Abnormality of fatty-acid metabolism (HP:0004359)3.79402576
23Proximal tubulopathy (HP:0000114)3.74532017
24Abnormality of nucleobase metabolism (HP:0010932)3.73836804
25Complement deficiency (HP:0004431)3.63884994
26Joint hemorrhage (HP:0005261)3.56481949
27Hyperuricemia (HP:0002149)3.54678619
28Increased purine levels (HP:0004368)3.54678619
29Alkalosis (HP:0001948)3.53633646
30Recurrent gram-negative bacterial infections (HP:0005420)3.53106507
31Hemorrhage of the eye (HP:0011885)3.47444554
32Generalized aminoaciduria (HP:0002909)3.44897506
33Delayed CNS myelination (HP:0002188)3.43697273
34Hypoglycemic coma (HP:0001325)3.43125882
35Fat malabsorption (HP:0002630)3.39144618
36Hypolipoproteinemia (HP:0010981)3.36946370
37Hypokalemic alkalosis (HP:0001949)3.35075712
38Hyperactive renin-angiotensin system (HP:0000841)3.33020988
39Abnormality of liposaccharide metabolism (HP:0010968)3.31276654
40Abnormality of glycosphingolipid metabolism (HP:0004343)3.31276654
41Abnormality of glycolipid metabolism (HP:0010969)3.31276654
42Abnormality of methionine metabolism (HP:0010901)3.22361415
43Abnormality of pyrimidine metabolism (HP:0004353)3.18246806
44Epidermoid cyst (HP:0200040)3.17371220
45Metabolic alkalosis (HP:0200114)3.15187585
46Vacuolated lymphocytes (HP:0001922)3.14504823
47Metabolic acidosis (HP:0001942)3.13468732
48Abnormality of the common coagulation pathway (HP:0010990)3.12738256
49Increased circulating renin level (HP:0000848)3.11412921
50Orchitis (HP:0100796)3.09162024
51Abnormality of dicarboxylic acid metabolism (HP:0010995)3.06744833
52Dicarboxylic aciduria (HP:0003215)3.06744833
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04917610
54Eczematoid dermatitis (HP:0000976)3.04789782
55Abnormality of polysaccharide metabolism (HP:0011012)3.02974644
56Abnormality of glycosaminoglycan metabolism (HP:0004371)3.02974644
57Abnormality of mucopolysaccharide metabolism (HP:0011020)3.02974644
58Vascular calcification (HP:0004934)3.02176775
59Increased cerebral lipofuscin (HP:0011813)2.98767788
60Myositis (HP:0100614)2.97837560
61Abnormality of macrophages (HP:0004311)2.95588532
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.94852541
63Hypoalphalipoproteinemia (HP:0003233)2.94047176
64Abnormality of urine glucose concentration (HP:0011016)2.92248596
65Glycosuria (HP:0003076)2.92248596
66Conjugated hyperbilirubinemia (HP:0002908)2.90855246
67Abnormality of serum amino acid levels (HP:0003112)2.90611729
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.89664386
69Dysostosis multiplex (HP:0000943)2.88805184
70Recurrent abscess formation (HP:0002722)2.87965305
71Nephritis (HP:0000123)2.85979362
72Lethargy (HP:0001254)2.85481498
73Abnormality of chloride homeostasis (HP:0011422)2.85247027
74Abnormal urine output (HP:0012590)2.85028962
75Abnormality of proline metabolism (HP:0010907)2.83107358
76Hydroxyprolinuria (HP:0003080)2.83107358
77Hyperbilirubinemia (HP:0002904)2.81593306
78Urinary glycosaminoglycan excretion (HP:0003541)2.81209533
79Mucopolysacchariduria (HP:0008155)2.81209533
80Malnutrition (HP:0004395)2.78796557
81Hypomagnesemia (HP:0002917)2.76189472
82Polyuria (HP:0000103)2.75637790
83Hepatocellular carcinoma (HP:0001402)2.72665507
84Purpura (HP:0000979)2.72269471
85Elevated erythrocyte sedimentation rate (HP:0003565)2.67420668
86Cardiovascular calcification (HP:0011915)2.67146801
87Abnormality of renal excretion (HP:0011036)2.65330025
88Abnormality of the intrinsic pathway (HP:0010989)2.64988831
89Amyloidosis (HP:0011034)2.60424157
90Abnormality of complement system (HP:0005339)2.60274726
91Vomiting (HP:0002013)2.58485862
92Retrobulbar optic neuritis (HP:0100654)2.58252024
93Optic neuritis (HP:0100653)2.58252024
94Recurrent bacterial skin infections (HP:0005406)2.57134045
95Steatorrhea (HP:0002570)2.53636916
96Hypercholesterolemia (HP:0003124)2.53165889
97Rickets (HP:0002748)2.52977744
98Irritability (HP:0000737)2.51696472
99Enlarged kidneys (HP:0000105)2.48914870
100Widely patent fontanelles and sutures (HP:0004492)2.47511106
101Increased serum ferritin (HP:0003281)2.47324340
102J-shaped sella turcica (HP:0002680)2.42757740
103Neonatal onset (HP:0003623)2.42441996
104Nephrolithiasis (HP:0000787)2.38391315
105Prolonged neonatal jaundice (HP:0006579)2.35747511
106Spastic diplegia (HP:0001264)2.34786377
107Abnormality of magnesium homeostasis (HP:0004921)2.34726953
108Gingivitis (HP:0000230)2.33628044
109Cerebral edema (HP:0002181)2.33120701
110Pustule (HP:0200039)2.32743211
111Congenital sensorineural hearing impairment (HP:0008527)2.30127961
112Abnormal enzyme/coenzyme activity (HP:0012379)2.29402746
113Loss of speech (HP:0002371)2.29125327
114Hyperphosphaturia (HP:0003109)2.28820384
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26207228
116Sensorimotor neuropathy (HP:0007141)2.26057574
117Renal tubular acidosis (HP:0001947)2.24174580
118Late onset (HP:0003584)2.22869003
119Ileus (HP:0002595)2.20773194
120Abnormality of iron homeostasis (HP:0011031)2.20137541
121Chronic diarrhea (HP:0002028)2.19506975
122Systemic lupus erythematosus (HP:0002725)2.19245271
123Obstructive lung disease (HP:0006536)2.17929712
124Chronic obstructive pulmonary disease (HP:0006510)2.17929712
125Abnormality of transition element cation homeostasis (HP:0011030)2.17013595
126Thin bony cortex (HP:0002753)2.17006148
127Gastrointestinal infarctions (HP:0005244)2.15579338
128Pancreatitis (HP:0001733)2.14988755
129Cerebral palsy (HP:0100021)2.11755406
130Petechiae (HP:0000967)2.10052117
131Confusion (HP:0001289)2.09374508
132Abnormality of alkaline phosphatase activity (HP:0004379)2.09258274
133Abnormal drinking behavior (HP:0030082)2.09224218
134Polydipsia (HP:0001959)2.09224218
135Myocardial infarction (HP:0001658)2.09088496
136Abnormality of renin-angiotensin system (HP:0000847)2.07451601
137Renal salt wasting (HP:0000127)2.04841659
138Abnormal tarsal ossification (HP:0008369)2.03562596
139Abdominal distention (HP:0003270)2.03339640
140Nausea (HP:0002018)2.01905913
141Hyperaldosteronism (HP:0000859)2.01373652
142Hypophosphatemia (HP:0002148)2.01339817
143Gingival bleeding (HP:0000225)2.01239415
144Abnormal urine phosphate concentration (HP:0012599)1.99747349
145Hypoglycemic seizures (HP:0002173)1.95599187
146Hypophosphatemic rickets (HP:0004912)1.95511805
147Esophageal varix (HP:0002040)1.95497140
148Spontaneous abortion (HP:0005268)1.95206761
149Axonal loss (HP:0003447)1.94986895
150Vasculitis (HP:0002633)1.94135954
151Pulmonary infiltrates (HP:0002113)1.93474451
152Protuberant abdomen (HP:0001538)1.93017166
153Focal segmental glomerulosclerosis (HP:0000097)1.92122366
154Retinal atrophy (HP:0001105)1.90761057
155Pigmentary retinal degeneration (HP:0001146)1.90283073
156Pulmonary embolism (HP:0002204)1.87050331
157Hemoptysis (HP:0002105)1.83178567
158Decreased circulating renin level (HP:0003351)1.81669910
159Stomatitis (HP:0010280)1.79627850
160Recurrent skin infections (HP:0001581)1.79121936
161Acne (HP:0001061)1.78664659
162Progressive neurologic deterioration (HP:0002344)1.78588613
163Facial shape deformation (HP:0011334)1.77811526
164Potter facies (HP:0002009)1.77811526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.64859200
2WNK45.02387655
3WNK34.65133949
4OXSR13.99105380
5FGFR43.63232719
6ERN13.37957246
7EPHA22.71854933
8SIK12.66750984
9MST1R2.46149650
10ACVR1B2.25477510
11LMTK22.19520686
12STK38L2.04591311
13RIPK41.99826265
14IRAK41.94604080
15INSRR1.94503538
16STK391.92322128
17MAP3K31.86873174
18TAOK31.82919952
19FRK1.82915024
20ERBB41.80896143
21MAPK111.47452759
22TAOK11.47378949
23TXK1.45095031
24TNK21.43950241
25PKN21.39430138
26PDK31.37557579
27PDK41.37557579
28DDR21.36108618
29PTK61.35546789
30TESK11.34648097
31GRK61.32528123
32TESK21.31707454
33MAP2K41.31658326
34TRIB31.29573400
35BLK1.26501403
36SGK4941.23705288
37SGK2231.23705288
38FLT31.23618482
39ABL21.23009035
40ZAP701.22437043
41PIK3CG1.22103223
42PINK11.20316267
43MATK1.18563503
44IKBKB1.18401165
45SIK21.17141816
46TYK21.13184600
47ADRBK21.11926402
48MAP3K71.11042206
49NEK11.09153312
50MAP2K31.08917892
51EPHB11.08124608
52MAP3K21.01944184
53TIE10.97789987
54PRKD20.97074016
55LATS10.95763983
56SGK30.95420893
57PRKAA20.94950051
58SIK30.93264006
59CDC42BPA0.93028292
60PDK20.90348068
61MAP3K140.90003712
62PIM20.89586752
63MET0.88322570
64SMG10.88142808
65JAK20.87265838
66DYRK1B0.87137082
67GSK3A0.87095249
68NEK90.85859040
69PIK3CA0.84555929
70SGK20.83837021
71KDR0.83770982
72ICK0.83102695
73MAP3K110.82272029
74MAP2K20.81374652
75MAPK150.80676655
76MAPKAPK30.79908140
77TGFBR20.75704538
78RPS6KA20.74930914
79PTK20.74626306
80IRAK30.74195388
81JAK30.73395828
82TBK10.72400801
83GRK70.71930883
84FES0.71602488
85PRPF4B0.70336443
86RIPK10.69724418
87TLK10.68592726
88STK380.68550429
89PRKAA10.66344490
90PRKCZ0.65855913
91MAP2K60.63535028
92SYK0.62704393
93ERBB20.61963805
94PRKCI0.61905741
95LRRK20.61612702
96CHUK0.61364002
97DAPK20.60537627
98MAPK40.59963172
99BTK0.57117122
100LYN0.56921399
101ITK0.55665153
102LCK0.55317940
103HIPK20.55261307
104MARK20.54819656
105PDPK10.54772512
106PRKACG0.54762864
107FGR0.53003859
108MAP3K100.52061961
109JAK10.48871995
110CSK0.46061186
111RPS6KC10.45234061
112RPS6KL10.45234061
113IRAK20.44466576
114WNK10.44355222
115RPS6KA60.43956723
116BMX0.42944420
117MAPK120.42728284
118HCK0.42387250
119CAMK2G0.40861262
120MUSK0.40498779
121MYLK0.39244828
122FGFR20.39153178
123CDK60.37662875
124MAP2K10.36337914
125EPHA30.34013635
126PDK10.33303979
127IKBKE0.32570909
128FER0.32037914
129PRKG20.28110533
130PRKCQ0.28034698
131TAOK20.26150727
132IGF1R0.25780341
133IRAK10.25357946
134GRK10.24616464
135PRKCA0.23412624
136NME20.23402642
137PRKCD0.22943152
138CSF1R0.21744689
139MAP4K10.21454968
140CSNK1G10.20824192
141MAP3K10.20723377
142PAK30.20409616
143KIT0.20169238
144MAP3K60.18348747
145MAP3K50.17623216
146MTOR0.17339506
147MST40.16254525
148EPHB20.16136691

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.70638709
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.64494767
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97951331
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.87295817
5Nitrogen metabolism_Homo sapiens_hsa009102.84366936
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.71534194
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70901279
8Tryptophan metabolism_Homo sapiens_hsa003802.70784824
9Arginine biosynthesis_Homo sapiens_hsa002202.66261110
10Butanoate metabolism_Homo sapiens_hsa006502.66046942
11Fatty acid degradation_Homo sapiens_hsa000712.54616106
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45746853
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38192126
14Propanoate metabolism_Homo sapiens_hsa006402.31252237
15Peroxisome_Homo sapiens_hsa041462.29782984
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21390583
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05613257
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98377640
19Complement and coagulation cascades_Homo sapiens_hsa046101.97672538
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.89333056
21beta-Alanine metabolism_Homo sapiens_hsa004101.85339498
22Histidine metabolism_Homo sapiens_hsa003401.82691267
23Fatty acid metabolism_Homo sapiens_hsa012121.80826029
24Chemical carcinogenesis_Homo sapiens_hsa052041.80584881
25Sulfur metabolism_Homo sapiens_hsa009201.80479393
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80091346
27PPAR signaling pathway_Homo sapiens_hsa033201.77045965
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.73305844
29Pyruvate metabolism_Homo sapiens_hsa006201.70570179
30Bile secretion_Homo sapiens_hsa049761.63993643
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60189221
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.59058147
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57329740
34Selenocompound metabolism_Homo sapiens_hsa004501.52123732
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50783436
36Retinol metabolism_Homo sapiens_hsa008301.46967924
37Phenylalanine metabolism_Homo sapiens_hsa003601.43432376
38Starch and sucrose metabolism_Homo sapiens_hsa005001.38543677
39Caffeine metabolism_Homo sapiens_hsa002321.38411472
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33998245
41Vitamin digestion and absorption_Homo sapiens_hsa049771.32822285
42Carbon metabolism_Homo sapiens_hsa012001.32255517
43Folate biosynthesis_Homo sapiens_hsa007901.31943608
44Allograft rejection_Homo sapiens_hsa053301.26528166
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.21739088
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20230978
47Biosynthesis of amino acids_Homo sapiens_hsa012301.19291781
48Tyrosine metabolism_Homo sapiens_hsa003501.18463438
49Arginine and proline metabolism_Homo sapiens_hsa003301.16827880
50Autoimmune thyroid disease_Homo sapiens_hsa053201.16283071
51Fatty acid elongation_Homo sapiens_hsa000621.15766809
52Staphylococcus aureus infection_Homo sapiens_hsa051501.14882464
53Graft-versus-host disease_Homo sapiens_hsa053321.14436964
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.12370092
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12360156
56Glutathione metabolism_Homo sapiens_hsa004801.10740736
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07356159
58Asthma_Homo sapiens_hsa053101.04286551
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.00021469
60Sulfur relay system_Homo sapiens_hsa041220.99535847
61ABC transporters_Homo sapiens_hsa020100.99136629
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97320611
63Fat digestion and absorption_Homo sapiens_hsa049750.97181173
64Steroid biosynthesis_Homo sapiens_hsa001000.95788457
65Leishmaniasis_Homo sapiens_hsa051400.91673078
66Lysine degradation_Homo sapiens_hsa003100.91569260
67Pertussis_Homo sapiens_hsa051330.90208895
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89744539
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87620119
70Type I diabetes mellitus_Homo sapiens_hsa049400.84289059
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80336230
72Glycerolipid metabolism_Homo sapiens_hsa005610.78553134
73Sphingolipid metabolism_Homo sapiens_hsa006000.73839744
74Osteoclast differentiation_Homo sapiens_hsa043800.72436341
75Ether lipid metabolism_Homo sapiens_hsa005650.69341302
76Pentose phosphate pathway_Homo sapiens_hsa000300.65862720
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64844200
78Tuberculosis_Homo sapiens_hsa051520.63031794
79Rheumatoid arthritis_Homo sapiens_hsa053230.58370976
80Vitamin B6 metabolism_Homo sapiens_hsa007500.56618403
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55813873
82One carbon pool by folate_Homo sapiens_hsa006700.54461398
83Metabolic pathways_Homo sapiens_hsa011000.53065433
84Antigen processing and presentation_Homo sapiens_hsa046120.52717617
85Fructose and mannose metabolism_Homo sapiens_hsa000510.51782375
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.50689945
87African trypanosomiasis_Homo sapiens_hsa051430.42486376
88TNF signaling pathway_Homo sapiens_hsa046680.39340586
89Hematopoietic cell lineage_Homo sapiens_hsa046400.38879880
90Galactose metabolism_Homo sapiens_hsa000520.35437854
91Toxoplasmosis_Homo sapiens_hsa051450.32023537
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31881543
93Phagosome_Homo sapiens_hsa041450.29438424
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28971123
95Influenza A_Homo sapiens_hsa051640.28438094
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28017984
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26354347
98Mineral absorption_Homo sapiens_hsa049780.23897293
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21861450
100Fatty acid biosynthesis_Homo sapiens_hsa000610.19722032
101Insulin resistance_Homo sapiens_hsa049310.17505493
102Renin-angiotensin system_Homo sapiens_hsa046140.15144362
103Protein digestion and absorption_Homo sapiens_hsa049740.15117447
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.14519142
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14202920
106Linoleic acid metabolism_Homo sapiens_hsa005910.12376856
107Other glycan degradation_Homo sapiens_hsa005110.11303257
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.09509161
109Prion diseases_Homo sapiens_hsa050200.07835942
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06368391
111Collecting duct acid secretion_Homo sapiens_hsa049660.06218258
112Arachidonic acid metabolism_Homo sapiens_hsa005900.06077295
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05259317
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.04638941
115Thyroid hormone synthesis_Homo sapiens_hsa049180.00283711
116Insulin signaling pathway_Homo sapiens_hsa04910-0.1926147
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1751949
118Regulation of autophagy_Homo sapiens_hsa04140-0.1554813
119Hepatitis C_Homo sapiens_hsa05160-0.1247516
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.1104868
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0932705
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0813740
123Oxidative phosphorylation_Homo sapiens_hsa00190-0.0755255
124Lysosome_Homo sapiens_hsa04142-0.0346944
125AMPK signaling pathway_Homo sapiens_hsa04152-0.0267640
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0121103
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0113088
128Glucagon signaling pathway_Homo sapiens_hsa04922-0.0048311

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