SLC22A17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89117724
2synaptic vesicle maturation (GO:0016188)5.71620488
3locomotory exploration behavior (GO:0035641)5.58429336
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28639647
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26189784
6vocalization behavior (GO:0071625)5.21684387
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.07755072
8synaptic vesicle exocytosis (GO:0016079)5.05504866
9glutamate secretion (GO:0014047)4.76671244
10regulation of synaptic vesicle exocytosis (GO:2000300)4.75520964
11regulation of glutamate receptor signaling pathway (GO:1900449)4.73738164
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.70524228
13neuron cell-cell adhesion (GO:0007158)4.67113894
14protein localization to synapse (GO:0035418)4.52546628
15neuronal action potential propagation (GO:0019227)4.47977908
16cerebellar granule cell differentiation (GO:0021707)4.43589183
17axon ensheathment in central nervous system (GO:0032291)4.41776449
18central nervous system myelination (GO:0022010)4.41776449
19regulation of neuronal synaptic plasticity (GO:0048168)4.40812185
20exploration behavior (GO:0035640)4.37642066
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36054552
22neurotransmitter secretion (GO:0007269)4.31148920
23regulation of synaptic vesicle transport (GO:1902803)4.23132616
24glutamate receptor signaling pathway (GO:0007215)4.16508728
25dendritic spine morphogenesis (GO:0060997)4.14445507
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.12462361
27synaptic transmission, glutamatergic (GO:0035249)4.10546922
28gamma-aminobutyric acid transport (GO:0015812)4.10454542
29layer formation in cerebral cortex (GO:0021819)4.09434924
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.06288168
31regulation of synapse structural plasticity (GO:0051823)4.06109832
32potassium ion homeostasis (GO:0055075)4.00697224
33neuron-neuron synaptic transmission (GO:0007270)3.89656198
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84756604
35cellular potassium ion homeostasis (GO:0030007)3.81836100
36amino acid import (GO:0043090)3.81370461
37long-term memory (GO:0007616)3.81100887
38transmission of nerve impulse (GO:0019226)3.79248439
39potassium ion import (GO:0010107)3.78775279
40neuron recognition (GO:0008038)3.75485969
41neurotransmitter-gated ion channel clustering (GO:0072578)3.71438815
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64959740
43positive regulation of membrane potential (GO:0045838)3.63473191
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62719835
45neurotransmitter transport (GO:0006836)3.62189045
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53210475
47regulation of dendritic spine morphogenesis (GO:0061001)3.50972708
48proline transport (GO:0015824)3.50390656
49regulation of synapse maturation (GO:0090128)3.50357877
50regulation of voltage-gated calcium channel activity (GO:1901385)3.48576540
51neuromuscular process controlling posture (GO:0050884)3.48369032
52sodium ion export (GO:0071436)3.47897305
53regulation of postsynaptic membrane potential (GO:0060078)3.47081736
54regulation of synaptic plasticity (GO:0048167)3.45792596
55axonal fasciculation (GO:0007413)3.44055285
56neuromuscular process controlling balance (GO:0050885)3.42720556
57cellular sodium ion homeostasis (GO:0006883)3.41154947
58auditory behavior (GO:0031223)3.40563049
59neuronal ion channel clustering (GO:0045161)3.38626383
60glycine transport (GO:0015816)3.38126958
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.37944612
62regulation of neurotransmitter levels (GO:0001505)3.37734665
63long-term synaptic potentiation (GO:0060291)3.33543314
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32888986
65cell migration in hindbrain (GO:0021535)3.32135799
66activation of protein kinase A activity (GO:0034199)3.31436274
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31256943
68prepulse inhibition (GO:0060134)3.30269081
69synaptic vesicle endocytosis (GO:0048488)3.29013284
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.28266773
71response to auditory stimulus (GO:0010996)3.28009603
72establishment of mitochondrion localization (GO:0051654)3.27287521
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27006119
74regulation of ARF protein signal transduction (GO:0032012)3.25661047
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.25349120
76regulation of vesicle fusion (GO:0031338)3.25179709
77regulation of neurotransmitter secretion (GO:0046928)3.24083022
78L-amino acid import (GO:0043092)3.22469243
79mating behavior (GO:0007617)3.21691935
80postsynaptic membrane organization (GO:0001941)3.20867382
81cerebellar Purkinje cell layer development (GO:0021680)3.20151924
82regulation of glutamate secretion (GO:0014048)3.16942583
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16115520
84neuromuscular synaptic transmission (GO:0007274)3.13469187
85presynaptic membrane assembly (GO:0097105)3.12868101
86adult walking behavior (GO:0007628)3.11347234
87dendrite morphogenesis (GO:0048813)3.10573271
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09824077
89positive regulation of synapse maturation (GO:0090129)3.09735119
90acidic amino acid transport (GO:0015800)3.08703971
91membrane hyperpolarization (GO:0060081)3.08276738
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07686105
93regulation of neurotransmitter transport (GO:0051588)3.07374843
94negative regulation of dendrite morphogenesis (GO:0050774)3.07231831
95presynaptic membrane organization (GO:0097090)3.06769725
96positive regulation of dendritic spine development (GO:0060999)3.06338057
97neurotransmitter uptake (GO:0001504)3.06028935
98cerebellar Purkinje cell differentiation (GO:0021702)3.05926593
99learning (GO:0007612)3.05498009
100cell differentiation in hindbrain (GO:0021533)3.04123685
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03795296
102membrane depolarization (GO:0051899)3.03208803
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02279764
104regulation of dendritic spine development (GO:0060998)3.00333973
105positive regulation of neurotransmitter transport (GO:0051590)3.00085548
106dendritic spine organization (GO:0097061)2.99654684
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99023488
108vesicle transport along microtubule (GO:0047496)2.98440337
109cell communication by electrical coupling (GO:0010644)2.97115884
110synaptic transmission (GO:0007268)2.96096351
111positive regulation of neurotransmitter secretion (GO:0001956)2.95738529
112regulation of synaptic transmission (GO:0050804)2.94117279
113behavioral fear response (GO:0001662)2.93814538
114behavioral defense response (GO:0002209)2.93814538
115synaptic vesicle transport (GO:0048489)2.93384275
116establishment of synaptic vesicle localization (GO:0097480)2.93384275
117positive regulation of synaptic transmission (GO:0050806)2.92796645
118synapse assembly (GO:0007416)2.92601385
119regulation of female receptivity (GO:0045924)2.91650448
120membrane depolarization during action potential (GO:0086010)2.90584698
121negative regulation of amino acid transport (GO:0051956)2.90057236
122G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89226645
123neuromuscular process (GO:0050905)2.88058164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96288277
2GBX2_23144817_ChIP-Seq_PC3_Human3.31961402
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20342433
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15832399
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14957682
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81099984
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81099984
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74223448
9REST_21632747_ChIP-Seq_MESCs_Mouse2.72898076
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.68362539
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67768417
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62297991
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61221650
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61134545
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.59243153
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57851589
17DROSHA_22980978_ChIP-Seq_HELA_Human2.51715311
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.37974980
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37765565
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.36986602
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30098068
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25508058
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.24832540
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.24104607
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12366074
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06597393
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04711175
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.00048601
29AR_21572438_ChIP-Seq_LNCaP_Human1.91357914
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84975147
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82810287
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.70829405
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67662837
34TAF15_26573619_Chip-Seq_HEK293_Human1.64959989
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60547132
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56298065
37SMAD4_21799915_ChIP-Seq_A2780_Human1.48447649
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42620821
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42124506
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.39133482
41ZNF274_21170338_ChIP-Seq_K562_Hela1.34649777
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34316378
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32346475
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30749342
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28502394
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28476597
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27972894
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27906648
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27267452
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.25372045
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.24596827
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24082197
53P300_19829295_ChIP-Seq_ESCs_Human1.22212049
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.21677070
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21265458
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20652300
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16866502
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16453952
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15265173
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14620331
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.14231662
62AR_19668381_ChIP-Seq_PC3_Human1.12383766
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12227035
64STAT3_23295773_ChIP-Seq_U87_Human1.11961749
65AR_25329375_ChIP-Seq_VCAP_Human1.11474581
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10921852
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07764708
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07641645
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07523743
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05458246
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.05424919
72* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04988656
73KDM2B_26808549_Chip-Seq_K562_Human1.04755507
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.04266119
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03752880
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03298598
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.02929973
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02159166
79RNF2_27304074_Chip-Seq_NSC_Mouse1.01543035
80* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01267142
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01053701
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00801154
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98885185
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98058493
85TCF4_23295773_ChIP-Seq_U87_Human0.97977528
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97930864
87IGF1R_20145208_ChIP-Seq_DFB_Human0.96285426
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.94392878
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.93002248
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92782457
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92589811
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91995597
93LXR_22292898_ChIP-Seq_THP-1_Human0.91892084
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91803305
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.91713393
96RUNX2_22187159_ChIP-Seq_PCA_Human0.91519716
97AHR_22903824_ChIP-Seq_MCF-7_Human0.90769830
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90580475
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90007638
100OCT4_19829295_ChIP-Seq_ESCs_Human0.89837923
101CTCF_27219007_Chip-Seq_Bcells_Human0.89650902
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.89619066
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89228263
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88801919
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.87690870
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86167818
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85836727
108TET1_21490601_ChIP-Seq_MESCs_Mouse0.84428288
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84174023
110TP53_16413492_ChIP-PET_HCT116_Human0.84147069
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83919717
112DPY_21335234_ChIP-Seq_ESCs_Mouse0.83847453
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.83768986
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82056113
115SMC4_20622854_ChIP-Seq_HELA_Human0.81673146
116ER_23166858_ChIP-Seq_MCF-7_Human0.80805197
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80672845
118JUN_21703547_ChIP-Seq_K562_Human0.80466866
119FUS_26573619_Chip-Seq_HEK293_Human0.80266554
120KLF4_19829295_ChIP-Seq_ESCs_Human0.79864934
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76649804
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75313089
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75313089
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.75147000
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73871389
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73154029
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72647987
128SMAD4_21741376_ChIP-Seq_ESCs_Human0.72255042
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.71453392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.24906043
2MP0003880_abnormal_central_pattern5.12841576
3MP0003635_abnormal_synaptic_transmissio4.11258484
4MP0004270_analgesia3.51435865
5MP0009745_abnormal_behavioral_response3.47161324
6MP0002064_seizures3.25494729
7MP0002063_abnormal_learning/memory/cond3.24627946
8MP0002822_catalepsy3.02331394
9MP0009046_muscle_twitch3.01958263
10MP0005423_abnormal_somatic_nervous2.97639201
11MP0001968_abnormal_touch/_nociception2.86786159
12MP0002572_abnormal_emotion/affect_behav2.76796565
13MP0002272_abnormal_nervous_system2.70841717
14MP0001486_abnormal_startle_reflex2.67200325
15MP0002734_abnormal_mechanical_nocicepti2.48657162
16MP0001501_abnormal_sleep_pattern2.28106930
17MP0001440_abnormal_grooming_behavior2.19263786
18MP0002736_abnormal_nociception_after2.18511728
19MP0003329_amyloid_beta_deposits2.06942593
20MP0002733_abnormal_thermal_nociception1.99781649
21MP0001970_abnormal_pain_threshold1.94872272
22MP0002067_abnormal_sensory_capabilities1.92088657
23MP0002735_abnormal_chemical_nociception1.89653016
24MP0000778_abnormal_nervous_system1.86152867
25MP0008569_lethality_at_weaning1.85856557
26MP0001529_abnormal_vocalization1.79685102
27MP0002557_abnormal_social/conspecific_i1.75225589
28MP0005386_behavior/neurological_phenoty1.74672404
29MP0004924_abnormal_behavior1.74672404
30MP0004885_abnormal_endolymph1.74017397
31MP0006276_abnormal_autonomic_nervous1.73189918
32MP0002184_abnormal_innervation1.71415188
33MP0009780_abnormal_chondrocyte_physiolo1.70765130
34MP0004811_abnormal_neuron_physiology1.64382157
35MP0001905_abnormal_dopamine_level1.62623342
36MP0004858_abnormal_nervous_system1.61986298
37MP0000955_abnormal_spinal_cord1.61888285
38MP0003122_maternal_imprinting1.60899923
39MP0004142_abnormal_muscle_tone1.60479449
40MP0005646_abnormal_pituitary_gland1.60221784
41MP0002909_abnormal_adrenal_gland1.58373036
42MP0005645_abnormal_hypothalamus_physiol1.55269072
43MP0001984_abnormal_olfaction1.49534769
44MP0002066_abnormal_motor_capabilities/c1.46384488
45MP0002882_abnormal_neuron_morphology1.45779513
46MP0000920_abnormal_myelination1.39950654
47MP0001502_abnormal_circadian_rhythm1.37200360
48MP0003633_abnormal_nervous_system1.36578330
49MP0003879_abnormal_hair_cell1.34095033
50MP0003787_abnormal_imprinting1.29622802
51MP0003690_abnormal_glial_cell1.27554644
52MP0003631_nervous_system_phenotype1.19593541
53MP0002152_abnormal_brain_morphology1.12102178
54MP0003634_abnormal_glial_cell1.11861059
55MP0002229_neurodegeneration1.09852479
56MP0004742_abnormal_vestibular_system1.08517704
57MP0000751_myopathy1.02954677
58MP0000013_abnormal_adipose_tissue0.98652928
59MP0003121_genomic_imprinting0.98065335
60MP0005551_abnormal_eye_electrophysiolog0.97885086
61MP0002653_abnormal_ependyma_morphology0.97798217
62MP0004145_abnormal_muscle_electrophysio0.96408915
63MP0001177_atelectasis0.96279176
64MP0003632_abnormal_nervous_system0.95199230
65MP0008872_abnormal_physiological_respon0.94575688
66MP0002069_abnormal_eating/drinking_beha0.94192837
67MP0003283_abnormal_digestive_organ0.91364273
68MP0000604_amyloidosis0.90874262
69MP0001188_hyperpigmentation0.90334150
70MP0003075_altered_response_to0.89374276
71MP0001485_abnormal_pinna_reflex0.87389542
72MP0005409_darkened_coat_color0.86595852
73MP0001963_abnormal_hearing_physiology0.86518873
74MP0008874_decreased_physiological_sensi0.85043860
75MP0000631_abnormal_neuroendocrine_gland0.81799719
76MP0002752_abnormal_somatic_nervous0.81694776
77MP0005535_abnormal_body_temperature0.81013161
78MP0008877_abnormal_DNA_methylation0.80148652
79MP0004085_abnormal_heartbeat0.79092530
80MP0008961_abnormal_basal_metabolism0.76304872
81MP0000566_synostosis0.76134059
82MP0005623_abnormal_meninges_morphology0.74188265
83MP0005499_abnormal_olfactory_system0.73837229
84MP0005394_taste/olfaction_phenotype0.73837229
85MP0001986_abnormal_taste_sensitivity0.73826150
86MP0002090_abnormal_vision0.73282815
87MP0005167_abnormal_blood-brain_barrier0.73218484
88MP0010386_abnormal_urinary_bladder0.71254376
89MP0003137_abnormal_impulse_conducting0.69980837
90MP0001348_abnormal_lacrimal_gland0.65011398
91MP0001299_abnormal_eye_distance/0.64541426
92MP0001664_abnormal_digestion0.64354009
93MP0002837_dystrophic_cardiac_calcinosis0.64238346
94MP0002638_abnormal_pupillary_reflex0.62853779
95MP0003938_abnormal_ear_development0.62620307
96MP0004043_abnormal_pH_regulation0.62272108
97MP0000579_abnormal_nail_morphology0.61229882
98MP0004147_increased_porphyrin_level0.60016994
99MP0001346_abnormal_lacrimal_gland0.59909002
100MP0006072_abnormal_retinal_apoptosis0.59200301
101MP0001943_abnormal_respiration0.58980257
102MP0000747_muscle_weakness0.58017551
103MP0004130_abnormal_muscle_cell0.56954551
104MP0002249_abnormal_larynx_morphology0.56703247
105MP0004133_heterotaxia0.56599577
106MP0002082_postnatal_lethality0.55927613
107MP0003861_abnormal_nervous_system0.55210021
108MP0005171_absent_coat_pigmentation0.54877393
109MP0010768_mortality/aging0.54785381
110MP0003123_paternal_imprinting0.53201095
111MP0003172_abnormal_lysosome_physiology0.52551863
112MP0010769_abnormal_survival0.51262474
113MP0004215_abnormal_myocardial_fiber0.50488481
114MP0000026_abnormal_inner_ear0.50097309
115MP0010770_preweaning_lethality0.49592629

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.18675382
2Myokymia (HP:0002411)7.08243167
3Focal seizures (HP:0007359)5.44597259
4Visual hallucinations (HP:0002367)5.14967904
5Epileptic encephalopathy (HP:0200134)4.35699554
6Atonic seizures (HP:0010819)4.24541295
7Supranuclear gaze palsy (HP:0000605)4.24459685
8Progressive cerebellar ataxia (HP:0002073)3.94873931
9Action tremor (HP:0002345)3.84746217
10Absence seizures (HP:0002121)3.81996090
11Febrile seizures (HP:0002373)3.78057850
12Ankle clonus (HP:0011448)3.74505409
13Neurofibrillary tangles (HP:0002185)3.71688825
14Generalized tonic-clonic seizures (HP:0002069)3.64325700
15Dialeptic seizures (HP:0011146)3.58001618
16Cerebral inclusion bodies (HP:0100314)3.41937766
17Obstructive sleep apnea (HP:0002870)3.37837873
18Dysmetria (HP:0001310)3.34909626
19Depression (HP:0000716)3.29159367
20Broad-based gait (HP:0002136)3.25259659
21Anxiety (HP:0000739)3.21869281
22Impaired vibration sensation in the lower limbs (HP:0002166)3.17213329
23Dysdiadochokinesis (HP:0002075)3.11495498
24Mutism (HP:0002300)3.10996139
25Abnormal eating behavior (HP:0100738)3.08597584
26Cerebral hypomyelination (HP:0006808)3.07805084
27Poor eye contact (HP:0000817)3.07223118
28Sleep apnea (HP:0010535)2.99268296
29Postural instability (HP:0002172)2.96497498
30Truncal ataxia (HP:0002078)2.96191357
31Urinary bladder sphincter dysfunction (HP:0002839)2.95299690
32Gaze-evoked nystagmus (HP:0000640)2.93264252
33Spastic gait (HP:0002064)2.92754595
34Intention tremor (HP:0002080)2.83279143
35Abnormal social behavior (HP:0012433)2.79672758
36Impaired social interactions (HP:0000735)2.79672758
37Hemiparesis (HP:0001269)2.78772301
38Tetraplegia (HP:0002445)2.77508024
39Abnormality of the corticospinal tract (HP:0002492)2.77366347
40Urinary urgency (HP:0000012)2.75836098
41Scanning speech (HP:0002168)2.75040468
42Hyperventilation (HP:0002883)2.71353960
43Amblyopia (HP:0000646)2.69012987
44Torticollis (HP:0000473)2.68402004
45Progressive inability to walk (HP:0002505)2.67792266
46Megalencephaly (HP:0001355)2.64809794
47Limb dystonia (HP:0002451)2.61982565
48Termporal pattern (HP:0011008)2.53908239
49Insidious onset (HP:0003587)2.53908239
50Abnormality of binocular vision (HP:0011514)2.51246188
51Diplopia (HP:0000651)2.51246188
52Focal dystonia (HP:0004373)2.49857064
53Papilledema (HP:0001085)2.47538561
54Hemiplegia (HP:0002301)2.43224210
55Bradykinesia (HP:0002067)2.42958329
56Excessive salivation (HP:0003781)2.42397793
57Drooling (HP:0002307)2.42397793
58Pheochromocytoma (HP:0002666)2.41383070
59Genetic anticipation (HP:0003743)2.41152037
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39931726
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.39931726
62Polyphagia (HP:0002591)2.39094371
63Lower limb muscle weakness (HP:0007340)2.37312529
64Abnormality of the lower motor neuron (HP:0002366)2.33757041
65Ventricular fibrillation (HP:0001663)2.26992801
66Craniofacial dystonia (HP:0012179)2.25905784
67Peripheral hypomyelination (HP:0007182)2.21654563
68Impaired smooth pursuit (HP:0007772)2.21476544
69Stereotypic behavior (HP:0000733)2.20180352
70Epileptiform EEG discharges (HP:0011182)2.19707138
71Neuronal loss in central nervous system (HP:0002529)2.18276786
72Apathy (HP:0000741)2.17745911
73Retinal dysplasia (HP:0007973)2.16382527
74Insomnia (HP:0100785)2.16331717
75Generalized myoclonic seizures (HP:0002123)2.16209866
76EEG with generalized epileptiform discharges (HP:0011198)2.13734440
77Morphological abnormality of the pyramidal tract (HP:0002062)2.11757241
78Spastic tetraparesis (HP:0001285)2.10590504
79Increased circulating renin level (HP:0000848)2.08838598
80Psychosis (HP:0000709)2.07719897
81Neuroendocrine neoplasm (HP:0100634)2.04663491
82Hypsarrhythmia (HP:0002521)2.04364188
83Status epilepticus (HP:0002133)2.04081034
84Delusions (HP:0000746)2.02574882
85Absent speech (HP:0001344)2.02318325
86Clonus (HP:0002169)2.01419119
87Turricephaly (HP:0000262)2.01202500
88Aplasia involving bones of the extremities (HP:0009825)1.99351822
89Aplasia involving bones of the upper limbs (HP:0009823)1.99351822
90Aplasia of the phalanges of the hand (HP:0009802)1.99351822
91Impaired vibratory sensation (HP:0002495)1.99030776
92Diminished motivation (HP:0000745)1.98673285
93Fetal akinesia sequence (HP:0001989)1.98100248
94Annular pancreas (HP:0001734)1.97267293
95Rigidity (HP:0002063)1.97148463
96Abnormality of ocular smooth pursuit (HP:0000617)1.96730000
97Choreoathetosis (HP:0001266)1.96524332
98CNS hypomyelination (HP:0003429)1.96304451
99Failure to thrive in infancy (HP:0001531)1.95629466
100Agitation (HP:0000713)1.95316319
101Rapidly progressive (HP:0003678)1.93040103
102Spinal canal stenosis (HP:0003416)1.92216296
103Gait ataxia (HP:0002066)1.88224134
104Bronchomalacia (HP:0002780)1.86420384
105Incomplete penetrance (HP:0003829)1.84508543
106Type II lissencephaly (HP:0007260)1.83969297
107Inability to walk (HP:0002540)1.83744376
108Spastic tetraplegia (HP:0002510)1.83500168
109Lower limb asymmetry (HP:0100559)1.83343768
110Abnormal EKG (HP:0003115)1.81251482
111Specific learning disability (HP:0001328)1.80453062
112Abnormality of saccadic eye movements (HP:0000570)1.79867691
113Split foot (HP:0001839)1.79271141
114Akinesia (HP:0002304)1.79016125
115Blue irides (HP:0000635)1.77994977
116Pointed chin (HP:0000307)1.77509087
117Hypoventilation (HP:0002791)1.76337619
118Hyperthyroidism (HP:0000836)1.72489156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.60192472
2NTRK34.36057656
3MAP3K93.83439767
4MARK12.73629377
5MAP3K42.68950045
6MINK12.54928265
7PAK62.25039532
8KSR22.22903528
9NTRK22.21279742
10MAP2K72.13866087
11DAPK22.11952622
12NTRK12.00966093
13PRKD31.99937690
14RIPK41.83173951
15MAP3K121.82297245
16ARAF1.81058135
17TNIK1.78454601
18PNCK1.76737749
19CAMKK11.63787212
20MAP2K41.63496903
21CDK51.59690925
22KSR11.56686380
23CDK191.48353272
24MAP3K131.47985424
25TYRO31.45790031
26UHMK11.41803883
27FES1.39636196
28CASK1.38995535
29GRK51.37559501
30RIPK11.36455291
31PLK21.31078063
32OXSR11.25950628
33PRPF4B1.24983322
34MAPK131.22227004
35SIK21.19769891
36PRKCG1.16112218
37STK381.14746613
38DAPK11.12685617
39MAP3K21.10919655
40STK391.10717698
41PHKG21.08505115
42PHKG11.08505115
43CAMK2A1.06015182
44CAMK2B1.00953549
45CDK150.98555916
46CDK180.98511631
47SGK2230.96980107
48SGK4940.96980107
49CDK140.96858200
50PRKCH0.89768322
51CAMKK20.88817723
52CDK11A0.86856872
53STK110.86481584
54CAMK10.85515183
55PAK30.85393461
56LMTK20.81869847
57RAF10.81211575
58CSNK1G20.80959093
59PTK2B0.78105936
60PINK10.76373477
61LATS20.75573507
62TAOK10.73516176
63MAPK120.73119653
64MARK20.72994065
65BMPR20.72195905
66TNK20.71930427
67FGR0.71879225
68RET0.71736939
69MAPKAPK50.70693455
70WNK10.69852048
71NEK60.69251825
72LIMK10.69211734
73MAP3K110.69053410
74DYRK1A0.68204851
75DYRK20.67358078
76CAMK2D0.67275032
77ALK0.66195063
78CAMK2G0.65862742
79BRSK10.64579179
80SGK10.63652338
81PDPK10.61894027
82CAMK40.61319883
83MAP3K10.59974208
84CAMK1G0.58586302
85ROCK20.56666829
86WNK40.56632482
87PDK10.55673005
88PKN10.54832779
89BCR0.54526438
90PRKCE0.52012460
91FYN0.49993183
92PRKCZ0.49422159
93NME10.47720284
94MUSK0.47107820
95SGK20.47037156
96RPS6KA30.46974354
97ERBB20.46907036
98FGFR20.46435449
99MAPK100.46420221
100CDC42BPA0.46412387
101SGK30.43033570
102ROCK10.41253122
103CSNK1G30.40077923
104FER0.38519536
105TESK10.38389053
106DAPK30.36355176
107ICK0.35516287
108MOS0.35102391
109PRKCA0.34968130
110BRAF0.34620794
111DDR20.33495276
112PRKACA0.31429571
113RPS6KA20.31373319
114MAP2K60.31359680
115MAPK80.30471036
116PRKG10.30331669
117SRC0.28143481
118CSNK1E0.26267670
119CSNK1D0.26222983

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.70607032
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27473579
3GABAergic synapse_Homo sapiens_hsa047272.83503566
4Olfactory transduction_Homo sapiens_hsa047402.74321079
5Circadian entrainment_Homo sapiens_hsa047132.65258252
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63340088
7Glutamatergic synapse_Homo sapiens_hsa047242.62883889
8Long-term potentiation_Homo sapiens_hsa047202.56337365
9Morphine addiction_Homo sapiens_hsa050322.51807298
10Amphetamine addiction_Homo sapiens_hsa050312.46798718
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22200119
12Dopaminergic synapse_Homo sapiens_hsa047282.15483974
13Salivary secretion_Homo sapiens_hsa049702.14207086
14Gastric acid secretion_Homo sapiens_hsa049711.93704065
15Insulin secretion_Homo sapiens_hsa049111.90790291
16Cocaine addiction_Homo sapiens_hsa050301.88905367
17Cholinergic synapse_Homo sapiens_hsa047251.88291734
18Long-term depression_Homo sapiens_hsa047301.74501447
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73507402
20Taste transduction_Homo sapiens_hsa047421.72381403
21Serotonergic synapse_Homo sapiens_hsa047261.72300518
22Renin secretion_Homo sapiens_hsa049241.68107580
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64310901
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61685962
25Collecting duct acid secretion_Homo sapiens_hsa049661.60839687
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57984624
27Calcium signaling pathway_Homo sapiens_hsa040201.55771020
28Vitamin B6 metabolism_Homo sapiens_hsa007501.44939791
29GnRH signaling pathway_Homo sapiens_hsa049121.42881040
30Gap junction_Homo sapiens_hsa045401.37355667
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26339704
32cAMP signaling pathway_Homo sapiens_hsa040241.25749796
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25027681
34Axon guidance_Homo sapiens_hsa043601.21923280
35Cardiac muscle contraction_Homo sapiens_hsa042601.19564946
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15887942
37Estrogen signaling pathway_Homo sapiens_hsa049151.11294866
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11227304
39Vibrio cholerae infection_Homo sapiens_hsa051101.08766183
40Melanogenesis_Homo sapiens_hsa049161.07125810
41Nitrogen metabolism_Homo sapiens_hsa009101.04987798
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02739132
43Glioma_Homo sapiens_hsa052141.01789048
44Type II diabetes mellitus_Homo sapiens_hsa049300.98792424
45ErbB signaling pathway_Homo sapiens_hsa040120.96277201
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96181248
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.94139265
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93778114
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.88605676
50Pancreatic secretion_Homo sapiens_hsa049720.86922757
51Phototransduction_Homo sapiens_hsa047440.83383631
52Dorso-ventral axis formation_Homo sapiens_hsa043200.82487709
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79167023
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77692479
55Thyroid hormone synthesis_Homo sapiens_hsa049180.77250337
56Oocyte meiosis_Homo sapiens_hsa041140.77211598
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74423684
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72750282
59Alzheimers disease_Homo sapiens_hsa050100.71457987
60Choline metabolism in cancer_Homo sapiens_hsa052310.70180518
61Dilated cardiomyopathy_Homo sapiens_hsa054140.69027858
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68991684
63MAPK signaling pathway_Homo sapiens_hsa040100.65133626
64Oxidative phosphorylation_Homo sapiens_hsa001900.64442712
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61324651
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57558366
67Ras signaling pathway_Homo sapiens_hsa040140.56775136
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.56775136
69Alcoholism_Homo sapiens_hsa050340.56593610
70Prion diseases_Homo sapiens_hsa050200.56309814
71Parkinsons disease_Homo sapiens_hsa050120.55623661
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55475975
73Type I diabetes mellitus_Homo sapiens_hsa049400.54483537
74VEGF signaling pathway_Homo sapiens_hsa043700.53928384
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.51928730
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51428848
77Endocytosis_Homo sapiens_hsa041440.51100790
78Bile secretion_Homo sapiens_hsa049760.50137921
79Rap1 signaling pathway_Homo sapiens_hsa040150.49647838
80Renal cell carcinoma_Homo sapiens_hsa052110.48023760
81Arginine and proline metabolism_Homo sapiens_hsa003300.47468036
82Glucagon signaling pathway_Homo sapiens_hsa049220.44009222
83Ovarian steroidogenesis_Homo sapiens_hsa049130.42684804
84Inositol phosphate metabolism_Homo sapiens_hsa005620.40987243
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40950765
86Wnt signaling pathway_Homo sapiens_hsa043100.39337465
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39256823
88Hippo signaling pathway_Homo sapiens_hsa043900.38505854
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37780781
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35810189
91Histidine metabolism_Homo sapiens_hsa003400.34341902
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.33981110
93Non-small cell lung cancer_Homo sapiens_hsa052230.33940316
94Tight junction_Homo sapiens_hsa045300.33781542
95AMPK signaling pathway_Homo sapiens_hsa041520.32677942
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32421040
97Arginine biosynthesis_Homo sapiens_hsa002200.32215876
98beta-Alanine metabolism_Homo sapiens_hsa004100.32062997
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31732476
100Butanoate metabolism_Homo sapiens_hsa006500.30950779
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30901141
102Ether lipid metabolism_Homo sapiens_hsa005650.30527687
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30524405
104Mineral absorption_Homo sapiens_hsa049780.30484583
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29398280
106Huntingtons disease_Homo sapiens_hsa050160.28693144
107Chemokine signaling pathway_Homo sapiens_hsa040620.28155441
108Insulin signaling pathway_Homo sapiens_hsa049100.27943985
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27020028
110African trypanosomiasis_Homo sapiens_hsa051430.26887046
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26621762
112mTOR signaling pathway_Homo sapiens_hsa041500.26523076
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26207722
114Circadian rhythm_Homo sapiens_hsa047100.25767176
115Protein digestion and absorption_Homo sapiens_hsa049740.24870027
116Endometrial cancer_Homo sapiens_hsa052130.24859884
117Hedgehog signaling pathway_Homo sapiens_hsa043400.23059803

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