SLC20A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.72660722
2muscle filament sliding (GO:0030049)5.72660722
3hemidesmosome assembly (GO:0031581)5.36827479
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.30420782
5L-phenylalanine catabolic process (GO:0006559)5.30420782
6L-phenylalanine metabolic process (GO:0006558)5.22110637
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.22110637
8lysine catabolic process (GO:0006554)5.00248733
9lysine metabolic process (GO:0006553)5.00248733
10actin-mediated cell contraction (GO:0070252)4.99469609
11aspartate family amino acid catabolic process (GO:0009068)4.82725172
12alpha-linolenic acid metabolic process (GO:0036109)4.81370513
13sarcoplasmic reticulum calcium ion transport (GO:0070296)4.77724230
14glyoxylate metabolic process (GO:0046487)4.77679347
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.74821721
16desmosome organization (GO:0002934)4.59778955
17dicarboxylic acid biosynthetic process (GO:0043650)4.44848763
18aromatic amino acid family catabolic process (GO:0009074)4.32533888
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.31649898
20kynurenine metabolic process (GO:0070189)4.28927312
212-oxoglutarate metabolic process (GO:0006103)4.11195933
22actin filament-based movement (GO:0030048)4.07844683
23negative regulation of fibrinolysis (GO:0051918)3.98108395
24bile acid biosynthetic process (GO:0006699)3.95128169
25amino-acid betaine metabolic process (GO:0006577)3.94636021
26glutamate metabolic process (GO:0006536)3.90440559
27short-chain fatty acid metabolic process (GO:0046459)3.89015241
28high-density lipoprotein particle remodeling (GO:0034375)3.88253686
29sulfur amino acid catabolic process (GO:0000098)3.87949812
30carnitine shuttle (GO:0006853)3.87576522
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.86114094
32cysteine metabolic process (GO:0006534)3.85685377
33acetyl-CoA metabolic process (GO:0006084)3.84192636
34cell-substrate junction assembly (GO:0007044)3.83585476
35skeletal muscle contraction (GO:0003009)3.83387770
36fatty acid transmembrane transport (GO:1902001)3.83071634
37serine family amino acid catabolic process (GO:0009071)3.82967974
38fatty acid beta-oxidation (GO:0006635)3.82369675
39regulation of triglyceride catabolic process (GO:0010896)3.81697987
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.78931446
41cellular ketone body metabolic process (GO:0046950)3.73474373
42dicarboxylic acid catabolic process (GO:0043649)3.71133521
43striated muscle contraction (GO:0006941)3.70084030
44alpha-amino acid catabolic process (GO:1901606)3.69949044
45regulation of skeletal muscle contraction (GO:0014819)3.67127452
46actomyosin structure organization (GO:0031032)3.66659634
47homocysteine metabolic process (GO:0050667)3.64527258
48ethanol oxidation (GO:0006069)3.63754052
49regulation of relaxation of muscle (GO:1901077)3.63675276
50regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.59524208
51regulation of fibrinolysis (GO:0051917)3.59233954
52cellular modified amino acid catabolic process (GO:0042219)3.55275406
53sarcomere organization (GO:0045214)3.54066790
54cardiac muscle contraction (GO:0060048)3.52444044
55reverse cholesterol transport (GO:0043691)3.52037214
56regulation of protein activation cascade (GO:2000257)3.51504172
57fatty acid oxidation (GO:0019395)3.50833031
58cellular amino acid catabolic process (GO:0009063)3.49929407
59tryptophan catabolic process (GO:0006569)3.49850537
60indole-containing compound catabolic process (GO:0042436)3.49850537
61indolalkylamine catabolic process (GO:0046218)3.49850537
62protein-lipid complex remodeling (GO:0034368)3.49651066
63macromolecular complex remodeling (GO:0034367)3.49651066
64plasma lipoprotein particle remodeling (GO:0034369)3.49651066
65carnitine metabolic process (GO:0009437)3.49573032
66protein carboxylation (GO:0018214)3.48667047
67peptidyl-glutamic acid carboxylation (GO:0017187)3.48667047
68lipid oxidation (GO:0034440)3.47405426
69glycine metabolic process (GO:0006544)3.46512253
70negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.46182648
71coenzyme catabolic process (GO:0009109)3.44740806
72fatty acid catabolic process (GO:0009062)3.41477196
73positive regulation of fatty acid oxidation (GO:0046321)3.40226493
74response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.40018887
75bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39816433
76regulation of cholesterol esterification (GO:0010872)3.39457058
77plasma lipoprotein particle clearance (GO:0034381)3.34862010
78negative regulation of sterol transport (GO:0032372)3.34180542
79negative regulation of cholesterol transport (GO:0032375)3.34180542
80tricarboxylic acid cycle (GO:0006099)3.31118949
81urea cycle (GO:0000050)3.31004989
82urea metabolic process (GO:0019627)3.31004989
83regulation of actin filament-based movement (GO:1903115)3.30425891
84monocarboxylic acid catabolic process (GO:0072329)3.30190289
85cardiac myofibril assembly (GO:0055003)3.29987553
86bile acid metabolic process (GO:0008206)3.29891099
87regulation of cholesterol homeostasis (GO:2000188)3.29354419
88regulation of fatty acid beta-oxidation (GO:0031998)3.28726680
89regulation of complement activation (GO:0030449)3.28656765
90tryptophan metabolic process (GO:0006568)3.28594942
91ketone body metabolic process (GO:1902224)3.28444162
92acylglycerol homeostasis (GO:0055090)3.27608544
93triglyceride homeostasis (GO:0070328)3.27608544
94regulation of fatty acid oxidation (GO:0046320)3.26879318
95negative regulation of fatty acid biosynthetic process (GO:0045717)3.25788991
96biotin metabolic process (GO:0006768)3.24705660
97serine family amino acid metabolic process (GO:0009069)3.24316874
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.23093998
99phospholipid homeostasis (GO:0055091)3.20322964
100cell-substrate adherens junction assembly (GO:0007045)3.19033117
101focal adhesion assembly (GO:0048041)3.19033117
102complement activation, alternative pathway (GO:0006957)3.18325195
103regulation of the force of heart contraction (GO:0002026)3.18269879
104response to muscle activity (GO:0014850)3.18087049
105carboxylic acid catabolic process (GO:0046395)3.15783406
106organic acid catabolic process (GO:0016054)3.15783406
107serine family amino acid biosynthetic process (GO:0009070)3.14072224
108positive regulation of lipid catabolic process (GO:0050996)3.12621710
109branched-chain amino acid catabolic process (GO:0009083)3.12569369
110fatty acid homeostasis (GO:0055089)3.10385042
111sodium ion export (GO:0071436)3.09898075
112striated muscle hypertrophy (GO:0014897)3.09791285
113negative regulation of potassium ion transmembrane transport (GO:1901380)3.07181517
114aromatic amino acid family metabolic process (GO:0009072)3.06681610
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06662712
116tyrosine metabolic process (GO:0006570)3.06260668
117muscle contraction (GO:0006936)3.04962336
118carnitine transmembrane transport (GO:1902603)3.04683854
119adherens junction assembly (GO:0034333)3.03913804
120cytoskeletal anchoring at plasma membrane (GO:0007016)3.02865985
121skeletal muscle adaptation (GO:0043501)3.02865858
122plasma membrane repair (GO:0001778)3.02638277
123regulation of cell communication by electrical coupling (GO:0010649)3.02442712
124regulation of cholesterol metabolic process (GO:0090181)3.02310722
125nitrogen cycle metabolic process (GO:0071941)3.01938250
126myofibril assembly (GO:0030239)3.00832821
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98249257
128creatine metabolic process (GO:0006600)2.97224044
129regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.95771127
130cell communication involved in cardiac conduction (GO:0086065)2.95751401
131low-density lipoprotein particle remodeling (GO:0034374)2.95675031
132carnitine transport (GO:0015879)2.95475445
133amino-acid betaine transport (GO:0015838)2.95475445
134cardiac muscle hypertrophy (GO:0003300)2.92853123
135negative regulation of protein localization to cell surface (GO:2000009)2.92107123
136NADH metabolic process (GO:0006734)2.91840833
137epithelial cell-cell adhesion (GO:0090136)2.82399963
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.81124949
139cardiac muscle tissue morphogenesis (GO:0055008)2.77372968
140keratinocyte proliferation (GO:0043616)2.75633054
141cell communication by electrical coupling (GO:0010644)2.75417901
142skeletal muscle fiber development (GO:0048741)2.74201081
143muscle tissue morphogenesis (GO:0060415)2.74099537
144myoblast fusion (GO:0007520)2.73120331
145muscle system process (GO:0003012)2.72672946
146positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.70823083
147skin morphogenesis (GO:0043589)2.69510369
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64922795
149muscle hypertrophy (GO:0014896)2.62300689
150regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61733202
151ventricular cardiac muscle cell action potential (GO:0086005)2.56865331
152cell adhesion mediated by integrin (GO:0033627)2.56398193
153endodermal cell differentiation (GO:0035987)2.55299921
154response to inactivity (GO:0014854)2.54894428
155striated muscle adaptation (GO:0014888)2.54146997
156muscle cell fate commitment (GO:0042693)2.52864958
157glomerular basement membrane development (GO:0032836)2.51257634
158regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45946763
159cardiac muscle cell development (GO:0055013)2.45644783
160actin filament depolymerization (GO:0030042)2.44626467
161syncytium formation by plasma membrane fusion (GO:0000768)2.44199934
162myotube cell development (GO:0014904)2.44107007
163atrioventricular valve morphogenesis (GO:0003181)2.43256646
164relaxation of cardiac muscle (GO:0055119)2.43239815
165regulation of p38MAPK cascade (GO:1900744)2.41740284
166cardiac cell development (GO:0055006)2.41093395
167cellular potassium ion homeostasis (GO:0030007)2.39899857
168regulation of protein localization to cell surface (GO:2000008)2.39475702
169relaxation of muscle (GO:0090075)2.38415391
170gap junction assembly (GO:0016264)2.38343699
171regulation of transforming growth factor beta2 production (GO:0032909)2.37715886
172regulation of skeletal muscle cell differentiation (GO:2001014)2.36716431
173planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36111459
174regulation of striated muscle contraction (GO:0006942)2.35240986
175skeletal muscle tissue development (GO:0007519)2.34795637
176myelination in peripheral nervous system (GO:0022011)2.34523895
177peripheral nervous system axon ensheathment (GO:0032292)2.34523895
178hypotonic response (GO:0006971)2.32586560
179COPI coating of Golgi vesicle (GO:0048205)2.30358941
180Golgi transport vesicle coating (GO:0048200)2.30358941
181negative regulation of inclusion body assembly (GO:0090084)2.29275613
182muscle cell cellular homeostasis (GO:0046716)2.27841825
183regulation of cardioblast differentiation (GO:0051890)2.27718029
184glycogen catabolic process (GO:0005980)2.26806857
185regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.25470266
186multicellular organismal water homeostasis (GO:0050891)2.25182378
187ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.24547956
188cell migration involved in heart development (GO:0060973)2.22283334
189heart trabecula formation (GO:0060347)2.21502052
190cardiac muscle adaptation (GO:0014887)2.19791456
191muscle hypertrophy in response to stress (GO:0003299)2.19791456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.41959802
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.68430968
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.49147822
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.07777475
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.66003438
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.63414400
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.56198700
8* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.26449225
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74772453
10CLOCK_20551151_ChIP-Seq_293T_Human2.28165247
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.21297373
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19682313
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.14536757
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.11945447
15ZNF263_19887448_ChIP-Seq_K562_Human2.03999265
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94186247
17EP300_21415370_ChIP-Seq_HL-1_Mouse1.84516108
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.81898198
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79389516
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.78056616
21TBX20_22080862_ChIP-Seq_HEART_Mouse1.78056616
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.73195219
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72616868
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72122784
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.67898820
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67469489
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67313270
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62666864
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52709485
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.49587683
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46194815
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46194815
33P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45581224
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43832069
35* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43645671
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36757547
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32598077
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31217419
39CJUN_26792858_Chip-Seq_BT549_Human1.24669354
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22439611
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21631794
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17840233
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.17649808
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17463992
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15948005
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15406357
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15406357
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14614806
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14308478
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13252840
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12979109
52TP53_18474530_ChIP-ChIP_U2OS_Human1.11708078
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11538143
54SOX2_20726797_ChIP-Seq_SW620_Human1.11126710
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10639251
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09832523
57LXR_22292898_ChIP-Seq_THP-1_Human1.09196242
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08941027
59* TP53_23651856_ChIP-Seq_MEFs_Mouse1.07952141
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.06836139
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06719649
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06514099
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05761001
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05634069
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03935085
66RACK7_27058665_Chip-Seq_MCF-7_Human1.03474938
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03441287
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03357862
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02979184
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.02747606
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02503571
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02254810
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01865218
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01623648
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.01341584
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.00981859
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00799173
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.00706905
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98557852
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98434296
81UBF1/2_26484160_Chip-Seq_HMECs_Human0.98329363
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.97554914
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97418194
84* SMAD3_21741376_ChIP-Seq_HESCs_Human0.97141349
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.96322353
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96223134
87TRIM28_21343339_ChIP-Seq_HEK293_Human0.96172148
88TP63_23658742_ChIP-Seq_EP156T_Human0.93841680
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93629403
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93431467
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93277045
92* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93012830
93ESR1_21235772_ChIP-Seq_MCF-7_Human0.92031842
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91826768
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91818166
96POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91016036
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90965469
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90873471
99RUNX1_27514584_Chip-Seq_MCF-7_Human0.89599687
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89583853
101CDX2_20551321_ChIP-Seq_CACO-2_Human0.89228701
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88558731
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88074798
104ATF3_27146783_Chip-Seq_COLON_Human0.84966997
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84612882
106* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84419543
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83371336
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83213283
109DROSHA_22980978_ChIP-Seq_HELA_Human0.82284191
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81813452
111CREB1_26743006_Chip-Seq_LNCaP_Human0.80892020
112CTCF_27219007_Chip-Seq_Bcells_Human0.80131595
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78648879
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78375339
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78326010
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77705021
117HTT_18923047_ChIP-ChIP_STHdh_Human0.76937608
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76904022
119KDM2B_26808549_Chip-Seq_K562_Human0.76840306
120TP53_16413492_ChIP-PET_HCT116_Human0.76192160
121TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75876807
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.75683513
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75637279
124* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75182841
125* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75182841
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.74813842
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74371427
128* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74295957
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73201087
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73140267
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.72706447
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.71836033
133GATA1_19941826_ChIP-Seq_K562_Human0.71271438
134* SMAD4_21741376_ChIP-Seq_HESCs_Human0.69220573
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.68640397
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.68187677
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68032003
138* TP63_22573176_ChIP-Seq_HFKS_Human0.66740756
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.65460159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.16381368
2MP0005360_urolithiasis4.56470188
3MP0005085_abnormal_gallbladder_physiolo4.12182803
4MP0003806_abnormal_nucleotide_metabolis3.69154549
5MP0002837_dystrophic_cardiac_calcinosis3.67067946
6MP0005365_abnormal_bile_salt3.62235867
7MP0000751_myopathy2.88211842
8MP0003646_muscle_fatigue2.81529397
9MP0004084_abnormal_cardiac_muscle2.74835316
10MP0008875_abnormal_xenobiotic_pharmacok2.72801992
11MP0009840_abnormal_foam_cell2.63764929
12MP0009780_abnormal_chondrocyte_physiolo2.63735004
13MP0003252_abnormal_bile_duct2.62202280
14MP0003705_abnormal_hypodermis_morpholog2.52449274
15MP0003941_abnormal_skin_development2.44119174
16MP0004215_abnormal_myocardial_fiber2.40043397
17MP0000749_muscle_degeneration2.36933195
18MP0005330_cardiomyopathy2.35843669
19MP0010329_abnormal_lipoprotein_level2.33920786
20MP0004036_abnormal_muscle_relaxation2.26392989
21MP0005332_abnormal_amino_acid2.18844471
22MP0005083_abnormal_biliary_tract2.10006058
23MP0004130_abnormal_muscle_cell2.06068987
24MP0004087_abnormal_muscle_fiber2.05680738
25MP0000762_abnormal_tongue_morphology2.00835148
26MP0002269_muscular_atrophy1.97390130
27MP0005257_abnormal_intraocular_pressure1.82221452
28MP0000013_abnormal_adipose_tissue1.81325793
29MP0000747_muscle_weakness1.77852036
30MP0003195_calcinosis1.77556524
31MP0003137_abnormal_impulse_conducting1.73545632
32MP0005666_abnormal_adipose_tissue1.60510972
33MP0002972_abnormal_cardiac_muscle1.60027129
34MP0006138_congestive_heart_failure1.57775608
35MP0010234_abnormal_vibrissa_follicle1.56241217
36MP0004270_analgesia1.56041752
37MP0002118_abnormal_lipid_homeostasis1.55713362
38MP0000566_synostosis1.54406175
39MP0000750_abnormal_muscle_regeneration1.53972326
40MP0005620_abnormal_muscle_contractility1.53689161
41MP0005023_abnormal_wound_healing1.53517002
42MP0010630_abnormal_cardiac_muscle1.53136460
43MP0008775_abnormal_heart_ventricle1.52017584
44MP0004145_abnormal_muscle_electrophysio1.48126728
45MP0005503_abnormal_tendon_morphology1.47579289
46MP0001666_abnormal_nutrient_absorption1.47014213
47MP0000467_abnormal_esophagus_morphology1.45928169
48MP0004233_abnormal_muscle_weight1.44046543
49MP0001958_emphysema1.41916904
50MP0004185_abnormal_adipocyte_glucose1.41123072
51MP0005670_abnormal_white_adipose1.40996673
52MP0002060_abnormal_skin_morphology1.40252358
53MP0003950_abnormal_plasma_membrane1.38895287
54MP0010030_abnormal_orbit_morphology1.38818865
55MP0005409_darkened_coat_color1.37973281
56MP0005385_cardiovascular_system_phenoty1.35953312
57MP0001544_abnormal_cardiovascular_syste1.35953312
58MP0005319_abnormal_enzyme/_coenzyme1.31831978
59MP0000759_abnormal_skeletal_muscle1.28617552
60MP0002106_abnormal_muscle_physiology1.27697179
61MP0003091_abnormal_cell_migration1.26875949
62MP0003690_abnormal_glial_cell1.26410644
63MP0000609_abnormal_liver_physiology1.24999091
64MP0009384_cardiac_valve_regurgitation1.23877004
65MP0006036_abnormal_mitochondrial_physio1.21746140
66MP0000003_abnormal_adipose_tissue1.17851432
67MP0001849_ear_inflammation1.15191752
68MP0003191_abnormal_cellular_cholesterol1.13379070
69MP0005623_abnormal_meninges_morphology1.12196117
70MP0005369_muscle_phenotype1.11430919
71MP0005584_abnormal_enzyme/coenzyme_acti1.09609470
72MP0002896_abnormal_bone_mineralization1.08811575
73MP0004484_altered_response_of1.08174081
74MP0004043_abnormal_pH_regulation1.06698146
75MP0003329_amyloid_beta_deposits1.06184604
76MP0004510_myositis1.04551708
77MP0003453_abnormal_keratinocyte_physiol1.04129341
78MP0004019_abnormal_vitamin_homeostasis1.00888423
79MP0005266_abnormal_metabolism1.00387379
80MP0004085_abnormal_heartbeat0.99992838
81MP0005375_adipose_tissue_phenotype0.99431472
82MP0002971_abnormal_brown_adipose0.98405425
83MP0002332_abnormal_exercise_endurance0.96777251
84MP0003045_fibrosis0.94941029
85MP0010352_gastrointestinal_tract_polyps0.93672348
86MP0010368_abnormal_lymphatic_system0.90971638
87MP0005451_abnormal_body_composition0.90324356
88MP0006035_abnormal_mitochondrial_morpho0.87283316
89MP0000767_abnormal_smooth_muscle0.86513714
90MP0000579_abnormal_nail_morphology0.85846316
91MP0002108_abnormal_muscle_morphology0.85347185
92MP0008438_abnormal_cutaneous_collagen0.83837254
93MP0004272_abnormal_basement_membrane0.81615642
94MP0000534_abnormal_ureter_morphology0.81228485
95MP0003879_abnormal_hair_cell0.79769861
96MP0002254_reproductive_system_inflammat0.79743521
97MP0003279_aneurysm0.77335772
98MP0003566_abnormal_cell_adhesion0.76896396
99MP0005167_abnormal_blood-brain_barrier0.76299876
100MP0000462_abnormal_digestive_system0.75388233
101MP0005165_increased_susceptibility_to0.75230907
102MP0010678_abnormal_skin_adnexa0.74862750
103MP0002127_abnormal_cardiovascular_syste0.74124852
104MP0003221_abnormal_cardiomyocyte_apopto0.72096736
105MP0003868_abnormal_feces_composition0.71563181
106MP0000733_abnormal_muscle_development0.71395869
107MP0005501_abnormal_skin_physiology0.71345929
108MP0004885_abnormal_endolymph0.70632911
109MP0004134_abnormal_chest_morphology0.70292441
110MP0009250_abnormal_appendicular_skeleto0.69936756
111MP0004858_abnormal_nervous_system0.69557684
112MP0009672_abnormal_birth_weight0.69269281
113MP0005187_abnormal_penis_morphology0.68982578
114MP0000604_amyloidosis0.68778529
115MP0005508_abnormal_skeleton_morphology0.68403674
116MP0008569_lethality_at_weaning0.68317781
117MP0009053_abnormal_anal_canal0.67632003
118MP0009643_abnormal_urine_homeostasis0.67133877
119MP0001216_abnormal_epidermal_layer0.65730642
120MP0002128_abnormal_blood_circulation0.64829654
121MP0002098_abnormal_vibrissa_morphology0.64759472
122MP0000266_abnormal_heart_morphology0.64730047
123MP0003011_delayed_dark_adaptation0.64536070
124MP0002168_other_aberrant_phenotype0.63416224
125MP0002089_abnormal_postnatal_growth/wei0.62760902
126MP0002078_abnormal_glucose_homeostasis0.62734913
127MP0003632_abnormal_nervous_system0.62386392
128MP0003656_abnormal_erythrocyte_physiolo0.62276123
129MP0003828_pulmonary_edema0.61815266
130MP0004859_abnormal_synaptic_plasticity0.61655844
131MP0000598_abnormal_liver_morphology0.61159409
132MP0002138_abnormal_hepatobiliary_system0.60972368
133MP0000383_abnormal_hair_follicle0.60971279
134MP0000920_abnormal_myelination0.60899272
135MP0005423_abnormal_somatic_nervous0.59861749
136MP0001661_extended_life_span0.59854893
137MP0010771_integument_phenotype0.59038614
138MP0002295_abnormal_pulmonary_circulatio0.57166896
139MP0005275_abnormal_skin_tensile0.57019264
140MP0005647_abnormal_sex_gland0.54209331
141MP0002796_impaired_skin_barrier0.52885372
142MP0003186_abnormal_redox_activity0.52466839
143MP0002234_abnormal_pharynx_morphology0.52011874
144MP0001299_abnormal_eye_distance/0.51636802

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.63668968
2Intrahepatic cholestasis (HP:0001406)4.84769329
3Deep venous thrombosis (HP:0002625)4.65071630
4Xanthomatosis (HP:0000991)4.36418220
5Sudden death (HP:0001699)4.20851164
6Exercise-induced myalgia (HP:0003738)4.08970642
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.08016225
8Myoglobinuria (HP:0002913)4.07565448
9Hyperlipoproteinemia (HP:0010980)4.03660669
10Exercise-induced muscle cramps (HP:0003710)4.01162733
11Hyperammonemia (HP:0001987)4.00529056
12Hypoalphalipoproteinemia (HP:0003233)3.96617919
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.83289258
14Ketosis (HP:0001946)3.80988750
15Hyporeflexia of lower limbs (HP:0002600)3.75695733
16Round ear (HP:0100830)3.66248421
17Hypoglycemic coma (HP:0001325)3.65253467
18Abnormality of glycine metabolism (HP:0010895)3.63620174
19Abnormality of serine family amino acid metabolism (HP:0010894)3.63620174
20Hyperglycinuria (HP:0003108)3.62136353
21Muscle fiber splitting (HP:0003555)3.55849342
22Hypolipoproteinemia (HP:0010981)3.51300767
23Ketoacidosis (HP:0001993)3.50638968
24Distal arthrogryposis (HP:0005684)3.48916494
25Calf muscle hypertrophy (HP:0008981)3.44443080
26Centrally nucleated skeletal muscle fibers (HP:0003687)3.43069745
27Hyperglycinemia (HP:0002154)3.42848823
28Right ventricular cardiomyopathy (HP:0011663)3.39513656
29Neck muscle weakness (HP:0000467)3.38584412
30Hypobetalipoproteinemia (HP:0003563)3.35424326
31Abnormality of skeletal muscle fiber size (HP:0012084)3.34857417
32Ventricular tachycardia (HP:0004756)3.32620256
33Myopathic facies (HP:0002058)3.31831223
34Atrophic scars (HP:0001075)3.28353428
35Protrusio acetabuli (HP:0003179)3.22490556
36Muscle hypertrophy of the lower extremities (HP:0008968)3.22373747
37Mildly elevated creatine phosphokinase (HP:0008180)3.16368763
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.13660310
39Premature rupture of membranes (HP:0001788)3.13292767
40Abnormality of fatty-acid metabolism (HP:0004359)3.00510527
41Increased connective tissue (HP:0009025)2.99754759
42Abnormality of the calf musculature (HP:0001430)2.96058671
43Ulnar deviation of the wrist (HP:0003049)2.95080410
44Spinal rigidity (HP:0003306)2.94258517
45Atrial fibrillation (HP:0005110)2.87821676
46Distal lower limb amyotrophy (HP:0008944)2.83982830
47Abnormality of methionine metabolism (HP:0010901)2.83509747
48Abnormality of sulfur amino acid metabolism (HP:0004339)2.79913093
49Prolonged partial thromboplastin time (HP:0003645)2.79782918
50Epidermoid cyst (HP:0200040)2.79720641
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78479572
52EMG: myopathic abnormalities (HP:0003458)2.73727263
53Rhabdomyolysis (HP:0003201)2.70412030
54Difficulty running (HP:0009046)2.68376984
55Complement deficiency (HP:0004431)2.63621321
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63181108
57Arterial tortuosity (HP:0005116)2.61475626
58Lipoatrophy (HP:0100578)2.61040625
59Primary atrial arrhythmia (HP:0001692)2.59082566
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56055595
61Dicarboxylic aciduria (HP:0003215)2.56055595
62Vascular tortuosity (HP:0004948)2.54585221
63Atrioventricular block (HP:0001678)2.53258127
64Syncope (HP:0001279)2.52189062
65Skin nodule (HP:0200036)2.51185485
66Cholelithiasis (HP:0001081)2.48587319
67Aortic aneurysm (HP:0004942)2.45995385
68Fragile skin (HP:0001030)2.44730491
69Supraventricular tachycardia (HP:0004755)2.44654878
70Supraventricular arrhythmia (HP:0005115)2.42588780
71Dilated cardiomyopathy (HP:0001644)2.41050911
72Popliteal pterygium (HP:0009756)2.39039640
73Abnormality of serum amino acid levels (HP:0003112)2.37531702
74Delayed CNS myelination (HP:0002188)2.36788906
75Abnormal gallbladder morphology (HP:0012437)2.33514642
76Bundle branch block (HP:0011710)2.33288342
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33047179
78Ventricular arrhythmia (HP:0004308)2.32470755
79Calcaneovalgus deformity (HP:0001848)2.32404801
80Lower limb amyotrophy (HP:0007210)2.31993639
81Hyperinsulinemic hypoglycemia (HP:0000825)2.31409922
82Heart block (HP:0012722)2.31259213
83Broad metatarsal (HP:0001783)2.29775984
84Abnormality of the Achilles tendon (HP:0005109)2.29074863
85Rimmed vacuoles (HP:0003805)2.28486562
86Scapular winging (HP:0003691)2.27967704
87Abnormality of the left ventricular outflow tract (HP:0011103)2.27102278
88Subaortic stenosis (HP:0001682)2.27102278
89Aortic dissection (HP:0002647)2.23359072
90Abnormality of the common coagulation pathway (HP:0010990)2.20506968
91Muscle stiffness (HP:0003552)2.20010252
92Abnormal atrioventricular conduction (HP:0005150)2.19724265
93Milia (HP:0001056)2.19580505
94Limb-girdle muscle atrophy (HP:0003797)2.19370578
95Absent phalangeal crease (HP:0006109)2.18049731
96Palpitations (HP:0001962)2.16563266
97Metabolic acidosis (HP:0001942)2.15878581
98EMG: neuropathic changes (HP:0003445)2.15460100
99Type 1 muscle fiber predominance (HP:0003803)2.13769461
100Asymmetric septal hypertrophy (HP:0001670)2.12612395
101Slender build (HP:0001533)2.11862092
102Cerebral edema (HP:0002181)2.07615147
103Pterygium (HP:0001059)2.06942772
104Turricephaly (HP:0000262)2.06817609
105Hypercholesterolemia (HP:0003124)2.04649117
106Abnormality of the neuromuscular junction (HP:0003398)2.04160099
107Fatigable weakness (HP:0003473)2.04160099
108Gowers sign (HP:0003391)2.03640202
109Deformed tarsal bones (HP:0008119)2.03408333
110Frequent falls (HP:0002359)2.02661956
111Hip contracture (HP:0003273)2.01497034
112Lethargy (HP:0001254)2.01311828
113Muscle fiber inclusion bodies (HP:0100299)1.98681915
114Back pain (HP:0003418)1.97369031
115Foot dorsiflexor weakness (HP:0009027)1.96821887
116Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96203803
117Prolonged QT interval (HP:0001657)1.95390131
118Fat malabsorption (HP:0002630)1.95322174
119Gout (HP:0001997)1.94831495
120Cerebral aneurysm (HP:0004944)1.94237605
121Increased variability in muscle fiber diameter (HP:0003557)1.93655366
122Abnormality of the foot musculature (HP:0001436)1.93113369
123Hyperkalemia (HP:0002153)1.92586158
124Generalized muscle weakness (HP:0003324)1.91870345
125Achilles tendon contracture (HP:0001771)1.91238470
126Myotonia (HP:0002486)1.88491933
127Spastic diplegia (HP:0001264)1.87277553
128Areflexia of lower limbs (HP:0002522)1.87057448
129Late onset (HP:0003584)1.86630526
130Pseudobulbar signs (HP:0002200)1.86092293
131Difficulty climbing stairs (HP:0003551)1.85977935
132Shallow orbits (HP:0000586)1.85901975
133Abnormality of nail color (HP:0100643)1.84584241
134Ragged-red muscle fibers (HP:0003200)1.84257394
135Limited hip movement (HP:0008800)1.84204940
136Hepatocellular carcinoma (HP:0001402)1.83578356
137Cholecystitis (HP:0001082)1.83512483
138Abnormal gallbladder physiology (HP:0012438)1.83512483
139Abnormality of the intrinsic pathway (HP:0010989)1.83051822
140Abnormality of the salivary glands (HP:0010286)1.81252882
141Malignant hyperthermia (HP:0002047)1.81164095
142Joint hemorrhage (HP:0005261)1.80292595
143Hyperbilirubinemia (HP:0002904)1.79737588
144Abnormality of complement system (HP:0005339)1.79185306
145Distal lower limb muscle weakness (HP:0009053)1.78752417
146Hypoglycemic seizures (HP:0002173)1.78374568
147Dysmetric saccades (HP:0000641)1.77495603
148Abnormal finger flexion creases (HP:0006143)1.76162044
149Onycholysis (HP:0001806)1.74672544
150Muscular dystrophy (HP:0003560)1.73738502
151Stridor (HP:0010307)1.72576840
152Ulnar bowing (HP:0003031)1.70978907
153Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70531184
154Bulbar palsy (HP:0001283)1.69702591
155Fetal akinesia sequence (HP:0001989)1.69162355
156Upper limb amyotrophy (HP:0009129)1.67457130
157Distal upper limb amyotrophy (HP:0007149)1.67457130
158Abnormality of the calcaneus (HP:0008364)1.65702927
159Breech presentation (HP:0001623)1.65210872
160Obstructive sleep apnea (HP:0002870)1.64491571
161Advanced eruption of teeth (HP:0006288)1.63921534
162Limb-girdle muscle weakness (HP:0003325)1.63556485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.28261727
2BCKDK3.85168815
3TRIB33.48946354
4PKN23.18730405
5PHKG12.98940945
6PHKG22.98940945
7SIK12.75317879
8OBSCN2.55937860
9LATS12.35590976
10LMTK22.32923264
11NEK12.14994008
12PDK31.94091402
13PDK41.94091402
14MAPK151.71612019
15PDGFRA1.69149334
16ERN11.67062691
17RIPK11.66978267
18MAPKAPK31.64671649
19PINK11.63703016
20EPHB11.57697873
21MET1.57434936
22DMPK1.52486371
23ICK1.44523207
24LIMK11.42757709
25LATS21.42026319
26PTK61.40567014
27PAK31.32421058
28FGFR21.24756741
29MAP3K71.22724515
30FGFR41.21648252
31PRKD11.18533121
32PIK3CA1.13227841
33TESK11.12293891
34MUSK1.10840570
35ERBB41.08516623
36PDK21.07481948
37BMX1.06071359
38FLT31.05539101
39CAMK2D1.05445742
40MARK11.04049332
41MYLK1.03054421
42MAPK121.01026165
43MAP3K31.00384961
44EPHA20.97233754
45STK38L0.96756980
46STK380.96502259
47INSRR0.94291759
48PAK60.93740777
49CAMK2G0.92912035
50MAP2K40.91559710
51MOS0.90054006
52PAK40.88008690
53WNK10.87447063
54PRKAA20.87079014
55MTOR0.85492079
56PTK20.85118981
57EPHB20.84949482
58MAP3K20.83461499
59FGFR10.81893432
60DDR20.81479722
61ARAF0.81199542
62SMG10.79026665
63PRKAA10.78421864
64ROCK10.76366268
65STK390.76328450
66STK240.76131028
67MAP3K130.75880364
68ROCK20.75108245
69TYRO30.73430937
70PKN10.73393912
71TGFBR20.72976020
72CAMK1D0.72422752
73PIK3CG0.68316671
74MAP2K30.67953692
75MAPK70.66697442
76AKT20.65859256
77EPHA30.64574889
78MAPK110.63534055
79CDC42BPA0.62835078
80MAP3K60.62023561
81FER0.61227995
82CAMK40.60720915
83MAP2K10.60712249
84WNK40.59335963
85PDPK10.58453125
86TIE10.58366170
87CDK120.58161759
88PRKD20.57822614
89EEF2K0.57562683
90PRKD30.56079978
91MAP3K120.55167474
92MARK20.54938114
93CAMK1G0.54660888
94CAMK2A0.54102569
95PRKG20.53203124
96KSR20.53068250
97PRKACG0.52840460
98RPS6KA20.52577342
99TRPM70.51254092
100MAP3K90.51153587
101PAK20.50860890
102RET0.50859804
103PRKACB0.50475473
104GSK3A0.50250519
105ALK0.48954793
106CAMK2B0.48849202
107SGK30.47654686
108MAP3K100.46481127
109NEK90.45725187
110DAPK30.44229620
111SGK2230.44222256
112SGK4940.44222256
113TAOK20.44164839
114NEK60.43704124
115PTK2B0.43536814
116PRPF4B0.42501629
117ILK0.42296910
118ERBB20.41269384
119EPHA40.41089357
120RPS6KA30.40131754
121ABL20.40052236
122NTRK10.39239535
123LRRK20.39116052
124FGFR30.39056052
125PDGFRB0.38939880
126MST1R0.37918485
127CDK60.37671651
128AKT30.37518783
129CSNK1D0.37028764
130MAPK100.36588628
131DYRK1B0.34629701
132SGK20.33461187

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.52690375
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.77141331
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.11246748
4Fatty acid degradation_Homo sapiens_hsa000712.98986861
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91091169
6Arginine biosynthesis_Homo sapiens_hsa002202.88634528
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73546440
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73459914
9Propanoate metabolism_Homo sapiens_hsa006402.71463055
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58846589
11Fatty acid metabolism_Homo sapiens_hsa012122.43365962
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28732318
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27146064
14Butanoate metabolism_Homo sapiens_hsa006502.21684507
15Tryptophan metabolism_Homo sapiens_hsa003802.13577685
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13304038
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.00543515
18PPAR signaling pathway_Homo sapiens_hsa033201.91124642
19Carbon metabolism_Homo sapiens_hsa012001.84522680
20Pyruvate metabolism_Homo sapiens_hsa006201.73369513
21Complement and coagulation cascades_Homo sapiens_hsa046101.69987382
22Fatty acid elongation_Homo sapiens_hsa000621.63495825
23Peroxisome_Homo sapiens_hsa041461.63120800
24Biosynthesis of amino acids_Homo sapiens_hsa012301.62189148
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59438478
26Bile secretion_Homo sapiens_hsa049761.58568661
27Circadian rhythm_Homo sapiens_hsa047101.56088953
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53982633
29beta-Alanine metabolism_Homo sapiens_hsa004101.51357930
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32001597
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.27266465
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24307183
33Chemical carcinogenesis_Homo sapiens_hsa052041.24095706
34Fatty acid biosynthesis_Homo sapiens_hsa000611.24007807
35Arginine and proline metabolism_Homo sapiens_hsa003301.21344722
36Protein digestion and absorption_Homo sapiens_hsa049741.20458524
37Starch and sucrose metabolism_Homo sapiens_hsa005001.18488115
38Phenylalanine metabolism_Homo sapiens_hsa003601.18119617
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16986337
40Lysine degradation_Homo sapiens_hsa003101.16616220
41Histidine metabolism_Homo sapiens_hsa003401.15291098
42Selenocompound metabolism_Homo sapiens_hsa004501.12133707
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08460774
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07372910
45Tyrosine metabolism_Homo sapiens_hsa003501.06596336
46Dilated cardiomyopathy_Homo sapiens_hsa054141.04514755
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99304761
48Renin secretion_Homo sapiens_hsa049240.98569611
49Retinol metabolism_Homo sapiens_hsa008300.98383370
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97131409
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.96008435
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95208476
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.93041889
54Fat digestion and absorption_Homo sapiens_hsa049750.92704234
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92293272
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91975527
57Calcium signaling pathway_Homo sapiens_hsa040200.91935013
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91306248
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91071676
60Cardiac muscle contraction_Homo sapiens_hsa042600.91005009
61Oxytocin signaling pathway_Homo sapiens_hsa049210.90828922
62Sulfur metabolism_Homo sapiens_hsa009200.87775445
63GnRH signaling pathway_Homo sapiens_hsa049120.85757263
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85304432
65Pancreatic secretion_Homo sapiens_hsa049720.85105985
66Caffeine metabolism_Homo sapiens_hsa002320.83783596
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83243380
68Long-term potentiation_Homo sapiens_hsa047200.82119665
69Small cell lung cancer_Homo sapiens_hsa052220.79704361
70ABC transporters_Homo sapiens_hsa020100.79614494
71Insulin secretion_Homo sapiens_hsa049110.79387111
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.77952680
73Hippo signaling pathway_Homo sapiens_hsa043900.73876661
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73625638
75Steroid biosynthesis_Homo sapiens_hsa001000.71873666
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.71553466
77Glycerolipid metabolism_Homo sapiens_hsa005610.68835671
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.68790914
79Estrogen signaling pathway_Homo sapiens_hsa049150.68640848
80Melanogenesis_Homo sapiens_hsa049160.68127163
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65345607
82Salivary secretion_Homo sapiens_hsa049700.62927659
83Gap junction_Homo sapiens_hsa045400.62539765
84Glioma_Homo sapiens_hsa052140.61420166
85Vitamin B6 metabolism_Homo sapiens_hsa007500.61344373
86Insulin resistance_Homo sapiens_hsa049310.59056293
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.58084839
88One carbon pool by folate_Homo sapiens_hsa006700.56591490
89Staphylococcus aureus infection_Homo sapiens_hsa051500.56529135
90Folate biosynthesis_Homo sapiens_hsa007900.56479305
91Circadian entrainment_Homo sapiens_hsa047130.56247509
92Thyroid cancer_Homo sapiens_hsa052160.56206059
93Glucagon signaling pathway_Homo sapiens_hsa049220.55737924
94Endometrial cancer_Homo sapiens_hsa052130.55507075
95cAMP signaling pathway_Homo sapiens_hsa040240.54868701
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54497805
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52787679
98Sulfur relay system_Homo sapiens_hsa041220.50743216
99Axon guidance_Homo sapiens_hsa043600.50718007
100Vitamin digestion and absorption_Homo sapiens_hsa049770.49430675
101Amphetamine addiction_Homo sapiens_hsa050310.49196353
102ErbB signaling pathway_Homo sapiens_hsa040120.48316389
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48126474
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48096083
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.47426146
106Bladder cancer_Homo sapiens_hsa052190.47287402
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46005661
108Inositol phosphate metabolism_Homo sapiens_hsa005620.44583115
109Sphingolipid metabolism_Homo sapiens_hsa006000.44306150
110Renal cell carcinoma_Homo sapiens_hsa052110.44057121
111Glutathione metabolism_Homo sapiens_hsa004800.42279796
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42165184
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41511393
114AMPK signaling pathway_Homo sapiens_hsa041520.38715983
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38568903
116Metabolic pathways_Homo sapiens_hsa011000.33003158
117Insulin signaling pathway_Homo sapiens_hsa049100.29576315
118Fructose and mannose metabolism_Homo sapiens_hsa000510.28904439
119Pentose phosphate pathway_Homo sapiens_hsa000300.28803328
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26794247
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.26610008
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26199483
123Prion diseases_Homo sapiens_hsa050200.23374234
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23178317
125Tight junction_Homo sapiens_hsa045300.22222094
126ECM-receptor interaction_Homo sapiens_hsa045120.21816676
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.21507461
128Galactose metabolism_Homo sapiens_hsa000520.20810671
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16170097
130Focal adhesion_Homo sapiens_hsa045100.16133740
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14010414
132Linoleic acid metabolism_Homo sapiens_hsa005910.11768258
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11184831
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09546436
135Proteoglycans in cancer_Homo sapiens_hsa052050.09409618
136Basal cell carcinoma_Homo sapiens_hsa052170.09299983
137Amoebiasis_Homo sapiens_hsa051460.09250438
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.07783444
139Gastric acid secretion_Homo sapiens_hsa049710.07265049
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07235936
141Adherens junction_Homo sapiens_hsa045200.04383104
142Thyroid hormone synthesis_Homo sapiens_hsa049180.04283318
143Viral myocarditis_Homo sapiens_hsa054160.03828942

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