SLC1A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)7.66478004
2melanin metabolic process (GO:0006582)7.58844265
3secondary metabolite biosynthetic process (GO:0044550)6.24242083
4melanocyte differentiation (GO:0030318)5.44158232
5pigment cell differentiation (GO:0050931)5.09795785
6locomotory exploration behavior (GO:0035641)4.87706312
7layer formation in cerebral cortex (GO:0021819)4.76445034
8gamma-aminobutyric acid transport (GO:0015812)4.49029973
9* alanine transport (GO:0032328)4.40781367
10cellular potassium ion homeostasis (GO:0030007)4.33159042
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28912532
12sodium ion export (GO:0071436)4.13773293
13cell communication by electrical coupling (GO:0010644)4.06311866
14vocalization behavior (GO:0071625)3.99159665
15amino acid import (GO:0043090)3.97606391
16neuron cell-cell adhesion (GO:0007158)3.92010888
17glutamate secretion (GO:0014047)3.87347885
18synaptic vesicle maturation (GO:0016188)3.79469634
19negative regulation of astrocyte differentiation (GO:0048712)3.74332063
20C4-dicarboxylate transport (GO:0015740)3.74014378
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.67328405
22negative regulation of sodium ion transport (GO:0010766)3.65782979
23exploration behavior (GO:0035640)3.65315212
24neurotransmitter-gated ion channel clustering (GO:0072578)3.64365401
25dendrite morphogenesis (GO:0048813)3.54341435
26positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48606842
27regulation of glutamate receptor signaling pathway (GO:1900449)3.46769031
28glial cell proliferation (GO:0014009)3.45927803
29negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.41285824
30regulation of synapse structural plasticity (GO:0051823)3.37147493
31synaptic vesicle exocytosis (GO:0016079)3.33977150
32axonal fasciculation (GO:0007413)3.33717617
33neurotransmitter secretion (GO:0007269)3.32690393
34dendritic spine morphogenesis (GO:0060997)3.31493614
35response to auditory stimulus (GO:0010996)3.30146513
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28558237
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.27691544
38dermatan sulfate biosynthetic process (GO:0030208)3.26675657
39L-amino acid import (GO:0043092)3.26049432
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25899057
41chondroitin sulfate catabolic process (GO:0030207)3.24315846
42cellular response to cholesterol (GO:0071397)3.22191359
43axon ensheathment in central nervous system (GO:0032291)3.22129587
44central nervous system myelination (GO:0022010)3.22129587
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21067073
46regulation of neuronal synaptic plasticity (GO:0048168)3.20144082
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.19188276
48oligodendrocyte differentiation (GO:0048709)3.17545682
49neuron recognition (GO:0008038)3.16646140
50cellular sodium ion homeostasis (GO:0006883)3.16621196
51neuroepithelial cell differentiation (GO:0060563)3.15684242
52auditory behavior (GO:0031223)3.15361960
53ganglioside metabolic process (GO:0001573)3.14877157
54innervation (GO:0060384)3.13763574
55glutamate receptor signaling pathway (GO:0007215)3.13067559
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.12881671
57protein localization to synapse (GO:0035418)3.12706838
58postsynaptic membrane organization (GO:0001941)3.12701566
59atrial cardiac muscle cell action potential (GO:0086014)3.10241969
60transmission of nerve impulse (GO:0019226)3.08502521
61astrocyte differentiation (GO:0048708)3.05463567
62cerebellar granule cell differentiation (GO:0021707)3.03325208
63dermatan sulfate metabolic process (GO:0030205)3.03318567
64cell migration in hindbrain (GO:0021535)3.00539539
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.00420083
66regulation of fever generation (GO:0031620)3.00142553
67gonadal mesoderm development (GO:0007506)2.98844978
68regulation of synaptic vesicle exocytosis (GO:2000300)2.98090137
69pyrimidine nucleobase catabolic process (GO:0006208)2.97247150
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90924978
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90603840
72regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83475825
73positive regulation of potassium ion transmembrane transport (GO:1901381)2.82189908
74potassium ion homeostasis (GO:0055075)2.81038640
75response to lipoprotein particle (GO:0055094)2.80543709
76chondroitin sulfate biosynthetic process (GO:0030206)2.79195800
77central nervous system projection neuron axonogenesis (GO:0021952)2.78498201
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78028662
79potassium ion import (GO:0010107)2.77716331
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77493841
81positive regulation of synapse assembly (GO:0051965)2.73489302
82negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73226545
83positive regulation of synapse maturation (GO:0090129)2.71574021
84macroautophagy (GO:0016236)2.70789502
85neuromuscular process controlling balance (GO:0050885)2.70547566
86glycine transport (GO:0015816)2.70432593
87regulation of astrocyte differentiation (GO:0048710)2.69385910
88regulation of penile erection (GO:0060405)2.69355978
89neurotransmitter transport (GO:0006836)2.68925178
90negative regulation of smoothened signaling pathway (GO:0045879)2.68834973
91glycosphingolipid catabolic process (GO:0046479)2.68650600
92response to dietary excess (GO:0002021)2.68453679
93response to histamine (GO:0034776)2.68164005
94cerebral cortex radially oriented cell migration (GO:0021799)2.68072998
95regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.65616196
96response to methylmercury (GO:0051597)2.65428482
97* proline transport (GO:0015824)2.64955817
98synapse assembly (GO:0007416)2.63783533
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.60626165
100lens fiber cell development (GO:0070307)2.59705700
101positive regulation of axon extension (GO:0045773)2.58068252
102long-term memory (GO:0007616)2.57956781
103ovulation cycle (GO:0042698)2.57877706
104presynaptic membrane assembly (GO:0097105)2.57727966
105establishment of mitochondrion localization (GO:0051654)2.57128454
106regulation of heat generation (GO:0031650)2.56392893
107prepulse inhibition (GO:0060134)2.55706196
108cellular response to sterol (GO:0036315)2.55547684
109negative regulation of glial cell differentiation (GO:0045686)2.55345064
110neuronal action potential propagation (GO:0019227)2.54905994
111dicarboxylic acid biosynthetic process (GO:0043650)2.54656632
112cGMP-mediated signaling (GO:0019934)2.53643781
113negative regulation of oligodendrocyte differentiation (GO:0048715)2.53625497
114* L-serine transport (GO:0015825)2.53305710
115acidic amino acid transport (GO:0015800)2.52368636
116synapse organization (GO:0050808)2.52363346
117positive regulation of dendritic spine development (GO:0060999)2.52169809
118nerve growth factor signaling pathway (GO:0038180)2.51878799
119regulation of neurotransmitter levels (GO:0001505)2.51852157
120negative regulation of catenin import into nucleus (GO:0035414)2.51601414
121glycolipid catabolic process (GO:0019377)2.50780043
122* synaptic transmission, glutamatergic (GO:0035249)2.50428737
123regulation of synaptic plasticity (GO:0048167)2.50260324
124establishment of nucleus localization (GO:0040023)2.50166642
125negative regulation of adenylate cyclase activity (GO:0007194)2.49103123
126membrane repolarization (GO:0086009)2.48667163
127activation of protein kinase A activity (GO:0034199)2.46185838
128axon regeneration (GO:0031103)2.45526000
129N-acetylneuraminate metabolic process (GO:0006054)2.44121686
130retinal rod cell development (GO:0046548)2.42669959
131enteric nervous system development (GO:0048484)2.39133168
132cerebellar Purkinje cell layer development (GO:0021680)2.37551418
133cAMP biosynthetic process (GO:0006171)2.36721207
134sialylation (GO:0097503)2.36077249
135regulation of ARF protein signal transduction (GO:0032012)2.35466481
136tyrosine metabolic process (GO:0006570)2.33448314
137adhesion of symbiont to host (GO:0044406)2.33095617
138pigment granule organization (GO:0048753)2.32908130
139L-glutamate transport (GO:0015813)2.31121676
140synaptic vesicle endocytosis (GO:0048488)2.30485394
141ceramide catabolic process (GO:0046514)2.29541124
142presynaptic membrane organization (GO:0097090)2.28512412
143mechanosensory behavior (GO:0007638)2.27797767
144protein localization to endosome (GO:0036010)2.27744956
145endosome to pigment granule transport (GO:0043485)2.27079872
146endosome to melanosome transport (GO:0035646)2.27079872
147bone resorption (GO:0045453)2.26177516
148regulation of early endosome to late endosome transport (GO:2000641)2.25927964
149negative regulation of neurotransmitter transport (GO:0051589)2.25274365
150peptidyl-tyrosine autophosphorylation (GO:0038083)2.24660131
151regulation of cholesterol storage (GO:0010885)2.23625721
152glial cell differentiation (GO:0010001)2.21735585
153activation of MAPKKK activity (GO:0000185)2.21068867
154oligosaccharide catabolic process (GO:0009313)2.20249794
155positive regulation of vascular permeability (GO:0043117)2.19556147
156endoplasmic reticulum organization (GO:0007029)2.18651672
157mannose metabolic process (GO:0006013)2.18445837
158cell morphogenesis involved in neuron differentiation (GO:0048667)2.18343897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18751352
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08229349
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91288091
4SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74156580
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73830201
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67778223
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67778223
8AR_21572438_ChIP-Seq_LNCaP_Human2.67250453
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53744296
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52883937
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52153855
12GBX2_23144817_ChIP-Seq_PC3_Human2.51166230
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.51143258
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49259435
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38667780
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.37424030
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29304830
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20958795
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.16738837
20LXR_22292898_ChIP-Seq_THP-1_Human2.14562807
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.12625278
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09905862
23DROSHA_22980978_ChIP-Seq_HELA_Human2.07501061
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.03194325
25REST_21632747_ChIP-Seq_MESCs_Mouse2.02997119
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97640140
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96402744
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95216824
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73411567
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.72463348
31VDR_21846776_ChIP-Seq_THP-1_Human1.71894079
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69602371
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69563861
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68922574
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66103601
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.65764188
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.63952538
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62755808
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62703582
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58849499
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.56682428
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56288086
43* MITF_21258399_ChIP-Seq_MELANOMA_Human1.51453450
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50297643
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46065751
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.40679522
47MYC_22102868_ChIP-Seq_BL_Human1.40622804
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40114068
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39919281
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38827994
51* RING1B_27294783_Chip-Seq_NPCs_Mouse1.38818471
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35662877
53* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35043789
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34906125
55KDM2B_26808549_Chip-Seq_DND41_Human1.34230745
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.32695678
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.32397796
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.31717730
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.29618185
60TP53_18474530_ChIP-ChIP_U2OS_Human1.28832195
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28753136
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28709807
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27262299
64RXR_22108803_ChIP-Seq_LS180_Human1.24477660
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.23953236
66SMC4_20622854_ChIP-Seq_HELA_Human1.23433025
67ZNF274_21170338_ChIP-Seq_K562_Hela1.22803089
68SMAD4_21799915_ChIP-Seq_A2780_Human1.22770482
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22700073
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22349680
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.20775671
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20747855
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20604402
74AR_19668381_ChIP-Seq_PC3_Human1.20275154
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.19997578
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19407716
77TP53_16413492_ChIP-PET_HCT116_Human1.19382222
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18547095
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18451448
80* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18225975
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17498844
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.17218882
83* KDM2B_26808549_Chip-Seq_K562_Human1.16708032
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.15833809
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15390798
86VDR_24787735_ChIP-Seq_THP-1_Human1.14913815
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14401951
88AR_25329375_ChIP-Seq_VCAP_Human1.14369888
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13619896
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12190335
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11942520
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11932253
93VDR_24763502_ChIP-Seq_THP-1_Human1.11557399
94AHR_22903824_ChIP-Seq_MCF-7_Human1.11167638
95* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10512349
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10243766
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10119100
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09428764
99ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09412076
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.08541667
101P300_19829295_ChIP-Seq_ESCs_Human1.08134899
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06500333
103* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05995996
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.05308437
105* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04276727
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04208745
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03676130
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03181473
109* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02313176
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02311549
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01845033
112* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01565580
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01066247
114TCF4_18268006_ChIP-ChIP_LS174T_Human1.00980188
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.00962599
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00823481
117BCAT_22108803_ChIP-Seq_LS180_Human1.00512093
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.00119747
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.99813555
120* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98999748
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.98941744
122CLOCK_20551151_ChIP-Seq_293T_Human0.98701824
123TP53_23651856_ChIP-Seq_MEFs_Mouse0.98441297
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97696386
125* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97234603
126* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97234603
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96446958
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95973797
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95626105
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90207252
131* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89969481
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89808638
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.89403561
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89344698
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.88041570
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87839068
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87452219
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85623440
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85555719
140RUNX_20019798_ChIP-Seq_JUKART_Human0.84759731
141NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83469508
142* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80370410
143TCF7_22412390_ChIP-Seq_EML_Mouse0.79898820
144SA1_27219007_Chip-Seq_ERYTHROID_Human0.79557909
145TP53_22127205_ChIP-Seq_IMR90_Human0.78977973
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78686282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.39567875
2MP0004859_abnormal_synaptic_plasticity4.11371535
3MP0000015_abnormal_ear_pigmentation3.47919154
4MP0004858_abnormal_nervous_system3.46007536
5MP0003136_yellow_coat_color2.88623083
6MP0003635_abnormal_synaptic_transmissio2.85777365
7MP0004270_analgesia2.72816748
8MP0000569_abnormal_digit_pigmentation2.69944919
9MP0003172_abnormal_lysosome_physiology2.65874405
10MP0000371_diluted_coat_color2.60769740
11MP0005174_abnormal_tail_pigmentation2.57474119
12MP0002254_reproductive_system_inflammat2.54638507
13MP0005058_abnormal_lysosome_morphology2.53498888
14MP0002095_abnormal_skin_pigmentation2.53454707
15MP0009780_abnormal_chondrocyte_physiolo2.51677036
16MP0005423_abnormal_somatic_nervous2.50168121
17MP0005408_hypopigmentation2.49918580
18MP0005171_absent_coat_pigmentation2.45922983
19MP0002877_abnormal_melanocyte_morpholog2.33864952
20MP0002063_abnormal_learning/memory/cond2.32786387
21MP0004381_abnormal_hair_follicle2.31417307
22MP0005257_abnormal_intraocular_pressure2.22973065
23MP0003329_amyloid_beta_deposits2.18681131
24MP0009745_abnormal_behavioral_response2.18148208
25MP0001968_abnormal_touch/_nociception2.15330246
26MP0004885_abnormal_endolymph2.15086749
27MP0005075_abnormal_melanosome_morpholog2.12762920
28MP0001486_abnormal_startle_reflex2.07549597
29MP0009046_muscle_twitch2.04098969
30MP0000778_abnormal_nervous_system2.00825205
31MP0002572_abnormal_emotion/affect_behav1.97105717
32MP0003880_abnormal_central_pattern1.96897322
33MP0002064_seizures1.96580640
34MP0002734_abnormal_mechanical_nocicepti1.92848328
35MP0001440_abnormal_grooming_behavior1.91349269
36MP0002736_abnormal_nociception_after1.89377231
37MP0009384_cardiac_valve_regurgitation1.89016772
38MP0005409_darkened_coat_color1.87148936
39MP0002075_abnormal_coat/hair_pigmentati1.80182514
40MP0002638_abnormal_pupillary_reflex1.76446063
41MP0002733_abnormal_thermal_nociception1.72860586
42MP0001984_abnormal_olfaction1.65303458
43MP0003279_aneurysm1.63678968
44MP0003303_peritoneal_inflammation1.63143443
45MP0005623_abnormal_meninges_morphology1.60538165
46MP0002653_abnormal_ependyma_morphology1.59044194
47MP0002557_abnormal_social/conspecific_i1.58939140
48MP0003690_abnormal_glial_cell1.58031315
49MP0001324_abnormal_eye_pigmentation1.56075774
50MP0005499_abnormal_olfactory_system1.52954867
51MP0005394_taste/olfaction_phenotype1.52954867
52MP0001299_abnormal_eye_distance/1.51994033
53MP0000920_abnormal_myelination1.46577077
54MP0003878_abnormal_ear_physiology1.44717295
55MP0005377_hearing/vestibular/ear_phenot1.44717295
56MP0005167_abnormal_blood-brain_barrier1.44546274
57MP0001502_abnormal_circadian_rhythm1.43509846
58MP0010030_abnormal_orbit_morphology1.43141711
59MP0002184_abnormal_innervation1.36506590
60MP0001970_abnormal_pain_threshold1.36484573
61MP0002067_abnormal_sensory_capabilities1.35692712
62MP0009840_abnormal_foam_cell1.34099273
63MP0002735_abnormal_chemical_nociception1.32643822
64MP0003634_abnormal_glial_cell1.31534061
65MP0005646_abnormal_pituitary_gland1.31214222
66MP0001186_pigmentation_phenotype1.30064989
67MP0002822_catalepsy1.27336274
68MP0000955_abnormal_spinal_cord1.27239033
69MP0001958_emphysema1.27028717
70MP0008438_abnormal_cutaneous_collagen1.26541852
71MP0001501_abnormal_sleep_pattern1.25711596
72MP0002089_abnormal_postnatal_growth/wei1.23852210
73MP0000049_abnormal_middle_ear1.23729061
74MP0002272_abnormal_nervous_system1.23718246
75MP0004233_abnormal_muscle_weight1.23384651
76MP0003283_abnormal_digestive_organ1.23256455
77MP0005451_abnormal_body_composition1.21974246
78MP0002882_abnormal_neuron_morphology1.19885419
79MP0002152_abnormal_brain_morphology1.19285176
80MP0008789_abnormal_olfactory_epithelium1.18925480
81MP0002909_abnormal_adrenal_gland1.18075091
82MP0008569_lethality_at_weaning1.17037789
83MP0005386_behavior/neurological_phenoty1.16605885
84MP0004924_abnormal_behavior1.16605885
85MP0004811_abnormal_neuron_physiology1.16102609
86MP0002090_abnormal_vision1.11310330
87MP0003633_abnormal_nervous_system1.09955651
88MP0009250_abnormal_appendicular_skeleto1.09922264
89MP0003122_maternal_imprinting1.06104203
90MP0006276_abnormal_autonomic_nervous1.05627924
91MP0002249_abnormal_larynx_morphology1.05069310
92MP0001485_abnormal_pinna_reflex1.00753103
93MP0002066_abnormal_motor_capabilities/c0.99565578
94MP0003631_nervous_system_phenotype0.99363421
95MP0000534_abnormal_ureter_morphology0.96802877
96MP0003632_abnormal_nervous_system0.96207562
97MP0000685_abnormal_immune_system0.95527414
98MP0003942_abnormal_urinary_system0.94725697
99MP0001177_atelectasis0.94002146
100MP0005645_abnormal_hypothalamus_physiol0.92769179
101MP0003861_abnormal_nervous_system0.92619561
102MP0000428_abnormal_craniofacial_morphol0.90800760
103MP0003300_gastrointestinal_ulcer0.89311921
104MP0000631_abnormal_neuroendocrine_gland0.88130350
105MP0001963_abnormal_hearing_physiology0.85239977
106MP0003755_abnormal_palate_morphology0.85023299
107MP0004142_abnormal_muscle_tone0.84013061
108MP0002229_neurodegeneration0.83942168
109MP0004272_abnormal_basement_membrane0.83926281
110MP0002116_abnormal_craniofacial_bone0.83898265
111MP0002233_abnormal_nose_morphology0.83168441
112MP0000604_amyloidosis0.82926650
113MP0003075_altered_response_to0.82196406
114MP0000026_abnormal_inner_ear0.81218254
115MP0003137_abnormal_impulse_conducting0.80654215
116MP0005508_abnormal_skeleton_morphology0.78621443
117MP0004134_abnormal_chest_morphology0.77441654
118MP0000747_muscle_weakness0.76331564
119MP0001270_distended_abdomen0.75535875
120MP0003385_abnormal_body_wall0.75282409
121MP0002295_abnormal_pulmonary_circulatio0.75144823
122MP0000751_myopathy0.74513080
123MP0003091_abnormal_cell_migration0.72270260
124MP0003115_abnormal_respiratory_system0.71124815
125MP0002751_abnormal_autonomic_nervous0.70203073
126MP0003941_abnormal_skin_development0.69668948
127MP0003183_abnormal_peptide_metabolism0.68441428
128MP0005187_abnormal_penis_morphology0.68413421
129MP0002752_abnormal_somatic_nervous0.68204598
130MP0001943_abnormal_respiration0.68103011
131MP0003045_fibrosis0.67829125
132MP0003705_abnormal_hypodermis_morpholog0.66643503
133MP0000343_altered_response_to0.62045506
134MP0010234_abnormal_vibrissa_follicle0.61674407
135MP0005253_abnormal_eye_physiology0.59322269
136MP0004043_abnormal_pH_regulation0.57779734
137MP0002896_abnormal_bone_mineralization0.49553202
138MP0001529_abnormal_vocalization0.47763760
139MP0005248_abnormal_Harderian_gland0.47406582
140MP0000749_muscle_degeneration0.46632619
141MP0004145_abnormal_muscle_electrophysio0.46382900
142MP0000639_abnormal_adrenal_gland0.46004910
143MP0005387_immune_system_phenotype0.44987728
144MP0001790_abnormal_immune_system0.44987728

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)5.24957522
2Ocular albinism (HP:0001107)4.99442591
3Aplasia of the phalanges of the hand (HP:0009802)4.91458560
4Aplasia involving bones of the extremities (HP:0009825)4.91458560
5Aplasia involving bones of the upper limbs (HP:0009823)4.91458560
6Patchy hypopigmentation of hair (HP:0011365)4.74497167
7Megalencephaly (HP:0001355)4.53324899
8Iris hypopigmentation (HP:0007730)4.39068938
9Hypoplasia of the fovea (HP:0007750)4.28241965
10Aplasia/Hypoplasia of the fovea (HP:0008060)4.28241965
11Heterochromia iridis (HP:0001100)4.12298429
12Abnormality of liposaccharide metabolism (HP:0010968)4.00668710
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.00668710
14Abnormality of glycolipid metabolism (HP:0010969)4.00668710
15Albinism (HP:0001022)3.60133407
16Peripheral hypomyelination (HP:0007182)3.45875722
17Hypopigmentation of the fundus (HP:0007894)3.42714968
18Myokymia (HP:0002411)3.39223439
19Abnormality of binocular vision (HP:0011514)3.28057115
20Diplopia (HP:0000651)3.28057115
21Aplasia/Hypoplasia of the macula (HP:0008059)3.26765844
22Abnormality of the fovea (HP:0000493)3.26146785
23Generalized hypopigmentation (HP:0007513)3.25944196
24Hemiparesis (HP:0001269)3.12214524
25Focal motor seizures (HP:0011153)3.03548426
26Hypoplasia of the iris (HP:0007676)3.02344697
27Neurofibrillary tangles (HP:0002185)3.02181714
28Cerebral inclusion bodies (HP:0100314)2.98650403
29Aplasia/Hypoplasia affecting the retina (HP:0008061)2.98554555
30Dysostosis multiplex (HP:0000943)2.95092610
31Gastrointestinal stroma tumor (HP:0100723)2.91316753
32Focal seizures (HP:0007359)2.88042399
33Epileptic encephalopathy (HP:0200134)2.84403225
34Increased cerebral lipofuscin (HP:0011813)2.82668328
35Back pain (HP:0003418)2.79065128
36Nuclear cataract (HP:0100018)2.64766732
37Hemiplegia (HP:0002301)2.54628049
38Vacuolated lymphocytes (HP:0001922)2.51439028
39Narrow nasal bridge (HP:0000446)2.50659143
40Synostosis involving the elbow (HP:0003938)2.49472628
41Humeroradial synostosis (HP:0003041)2.49472628
42Neonatal short-limb short stature (HP:0008921)2.49279364
43Spastic paraparesis (HP:0002313)2.49029585
44Neuronal loss in central nervous system (HP:0002529)2.47586267
45Hand muscle atrophy (HP:0009130)2.47365724
46Apathy (HP:0000741)2.46672853
47Bronchomalacia (HP:0002780)2.45952271
48Progressive cerebellar ataxia (HP:0002073)2.43144360
49Supranuclear gaze palsy (HP:0000605)2.41489252
50J-shaped sella turcica (HP:0002680)2.36463974
51Onycholysis (HP:0001806)2.34308152
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.33044520
53Global brain atrophy (HP:0002283)2.32198749
54Fibular aplasia (HP:0002990)2.27582823
55Loss of speech (HP:0002371)2.26212619
56Diminished motivation (HP:0000745)2.25698239
57Hyperacusis (HP:0010780)2.24697585
58Shallow orbits (HP:0000586)2.19785594
59Visual hallucinations (HP:0002367)2.16746320
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15189611
61Urinary glycosaminoglycan excretion (HP:0003541)2.12519964
62Mucopolysacchariduria (HP:0008155)2.12519964
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11567207
64Abnormality of polysaccharide metabolism (HP:0011012)2.11567207
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11567207
66Mixed hearing impairment (HP:0000410)2.10380489
67Akinesia (HP:0002304)2.09785244
68Supernumerary nipples (HP:0002558)2.08696303
69Pseudobulbar signs (HP:0002200)2.07237433
70Paraparesis (HP:0002385)2.05257338
71Limb dystonia (HP:0002451)2.05023628
72Action tremor (HP:0002345)2.04148669
73Overgrowth (HP:0001548)2.03813029
74Morphological abnormality of the middle ear (HP:0008609)2.00203858
75Coronal craniosynostosis (HP:0004440)1.99138350
76Febrile seizures (HP:0002373)1.98635571
77Alacrima (HP:0000522)1.98362470
78Protrusio acetabuli (HP:0003179)1.97965233
79Long nose (HP:0003189)1.95260138
80Abnormality of the periventricular white matter (HP:0002518)1.94998016
81Bilateral sensorineural hearing impairment (HP:0008619)1.94682288
82Generalized tonic-clonic seizures (HP:0002069)1.94444138
83Deformed sella turcica (HP:0002681)1.92498785
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92359027
85Spastic gait (HP:0002064)1.91148822
86Hypoplastic left heart (HP:0004383)1.89227506
87Abnormal auditory evoked potentials (HP:0006958)1.88282150
88Insomnia (HP:0100785)1.87681462
89Split foot (HP:0001839)1.86744318
90Truncal ataxia (HP:0002078)1.85240461
91Abnormality of the axillary hair (HP:0100134)1.85044770
92Abnormality of secondary sexual hair (HP:0009888)1.85044770
93Exercise-induced myalgia (HP:0003738)1.84988216
94Potter facies (HP:0002009)1.83588857
95Facial shape deformation (HP:0011334)1.83588857
96Distal upper limb amyotrophy (HP:0007149)1.82491631
97Upper limb amyotrophy (HP:0009129)1.82491631
98Premature rupture of membranes (HP:0001788)1.81810323
99Annular pancreas (HP:0001734)1.81159989
100Abnormality of the middle phalanges of the toes (HP:0010183)1.81131851
101Depression (HP:0000716)1.81064995
102Short hallux (HP:0010109)1.81012704
103Absent hair (HP:0002298)1.80807077
104Asymmetric septal hypertrophy (HP:0001670)1.80430627
105Abnormal eating behavior (HP:0100738)1.80225092
106Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78934550
107Broad alveolar ridges (HP:0000187)1.78709001
108Ovoid vertebral bodies (HP:0003300)1.78147420
109Cutaneous syndactyly (HP:0012725)1.77972194
110Generalized hypopigmentation of hair (HP:0011358)1.77946130
111Blue irides (HP:0000635)1.75695739
112Frequent falls (HP:0002359)1.73482815
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73154101
114Hypoplastic toenails (HP:0001800)1.72533122
115Hyperventilation (HP:0002883)1.71499879
116Drooling (HP:0002307)1.70777324
117Excessive salivation (HP:0003781)1.70777324
118Turricephaly (HP:0000262)1.70227845
119Postural instability (HP:0002172)1.70056344
120Short 4th metacarpal (HP:0010044)1.69489923
121Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69489923
122Atonic seizures (HP:0010819)1.69428683
123Cupped ribs (HP:0000887)1.67864101
124Pheochromocytoma (HP:0002666)1.67492228
125Status epilepticus (HP:0002133)1.67433193
126Arterial tortuosity (HP:0005116)1.66674935
127Dysdiadochokinesis (HP:0002075)1.66330165
128Ankle clonus (HP:0011448)1.66183229
129Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.66125685
130Cerebral aneurysm (HP:0004944)1.65358252
131Polyphagia (HP:0002591)1.65316366
132Hypoventilation (HP:0002791)1.65294393
133Relative macrocephaly (HP:0004482)1.64593733
134Adactyly (HP:0009776)1.64261044
135Vascular tortuosity (HP:0004948)1.63997317
136Ankyloglossia (HP:0010296)1.63816345
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.63662867
138Neoplasm of the heart (HP:0100544)1.62803680
139EEG with generalized epileptiform discharges (HP:0011198)1.62643725
140Hypsarrhythmia (HP:0002521)1.62559868
141Mitral stenosis (HP:0001718)1.61704583
142Exercise-induced muscle cramps (HP:0003710)1.61153138
143Adducted thumb (HP:0001181)1.61065051
144Large for gestational age (HP:0001520)1.60589981
145Absence seizures (HP:0002121)1.60527239
146Abnormality of dentin (HP:0010299)1.59886669
147Rigidity (HP:0002063)1.58173378
148Hypoplastic nipples (HP:0002557)1.57747534
149Termporal pattern (HP:0011008)1.57333111
150Insidious onset (HP:0003587)1.57333111
151Abnormality of the diencephalon (HP:0010662)1.56519359
152Genetic anticipation (HP:0003743)1.56418586
153Abnormality of vision evoked potentials (HP:0000649)1.56141043
154Epileptiform EEG discharges (HP:0011182)1.55774790
155Premature graying of hair (HP:0002216)1.55429086
156Athetosis (HP:0002305)1.54406337
157Mutism (HP:0002300)1.53667825
158Abnormality of the corticospinal tract (HP:0002492)1.51786363
159Hepatoblastoma (HP:0002884)1.51323115
160Impaired vibration sensation in the lower limbs (HP:0002166)1.51277646
161Atrioventricular canal defect (HP:0006695)1.51020399
162Aqueductal stenosis (HP:0002410)1.50693762
163Choanal stenosis (HP:0000452)1.49899656
164Microglossia (HP:0000171)1.49714215
165Urinary bladder sphincter dysfunction (HP:0002839)1.48986527
166Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.48596638
167Dialeptic seizures (HP:0011146)1.47418032
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.47299164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.32121475
2NTRK23.19964808
3EPHA43.01930776
4NTRK32.97360548
5LMTK22.96387055
6PHKG22.94794040
7PHKG12.94794040
8MAP3K92.88524075
9PRKD32.83407333
10LATS22.52983865
11MINK12.41000944
12MAP3K42.23396932
13CASK2.07208676
14TNIK1.89824145
15MAPK151.86608545
16TRIB31.85580665
17DDR21.85543337
18NTRK11.85149504
19PAK61.70737863
20MAP3K21.63241294
21SIK11.60407079
22KSR11.59007010
23DAPK21.58205224
24MAPK131.56062130
25MAP2K71.52175513
26PAK31.48056984
27NEK91.42998962
28ERN11.41200652
29ARAF1.36343172
30FGFR31.35801451
31MAPKAPK31.31338982
32EPHA31.29640818
33EPHB21.27538695
34PLK21.24258141
35IRAK31.24141106
36CDK31.24019271
37KIT1.20618533
38KSR21.20545432
39TYRO31.18381658
40FGFR41.17296794
41CDK51.16623840
42CAMKK11.16140048
43MAP3K131.16106909
44ERBB31.15351957
45RIPK41.12692402
46PDGFRA1.10366168
47MAP3K141.09367865
48CCNB11.08881139
49SIK21.08281138
50PRKCG1.07486501
51PIM21.06289680
52PKN11.06216890
53MAP2K41.05108481
54ALK1.04815830
55WEE11.03653087
56MAPK70.98894729
57MAP4K10.98303763
58SGK20.97691639
59MARK30.94515715
60SGK4940.93414939
61SGK2230.93414939
62MOS0.90768657
63OBSCN0.90197159
64DYRK20.89647964
65MAPK110.89622057
66RET0.88715107
67TBK10.87248406
68FER0.87139100
69MAPK40.86267881
70SGK30.85207380
71TAOK30.82445540
72MAPK120.81228642
73CSNK1G20.80068134
74TTN0.79937862
75ADRBK10.79183070
76PINK10.76883130
77JAK10.76815958
78MAP2K10.75999817
79CDK150.75319837
80CDK140.74994845
81MAPKAPK50.73589070
82CDK180.73341499
83PRPF4B0.72680011
84PRKD20.72287040
85PIK3CG0.72213382
86PDK10.71371530
87PRKCE0.70816464
88CAMK2A0.70811133
89ROCK10.69955538
90DYRK1A0.68859929
91BMX0.67936971
92GRK50.67547649
93CSNK1G30.65577803
94PRKD10.63951832
95FGFR20.63520533
96SYK0.62577942
97ERBB40.61606537
98CDK11A0.61442360
99STK380.60983607
100PDPK10.60082939
101FGFR10.59169685
102PNCK0.58140312
103CAMK2G0.57865602
104UHMK10.57258249
105PRKCH0.57103754
106CAMK2D0.56869069
107BLK0.56695466
108MATK0.56376425
109RAF10.55684727
110PRKCZ0.55585794
111MAP3K110.54471633
112TAOK20.52815594
113CAMK1G0.52067659
114MAP3K10.51409797
115RPS6KB10.51248210
116PTK20.51022932
117STK240.49963185
118ROCK20.49202962
119SCYL20.49193928
120TAOK10.49009069
121MARK20.48214538
122EEF2K0.47678503
123AKT30.47522040
124SGK10.47470647
125ERBB20.45671010
126MUSK0.45501059
127FGR0.44188896
128LIMK10.41972961
129CDC42BPA0.41960520
130MAPK100.39225661
131RPS6KA30.38992475
132AKT20.38491861
133STK110.38354857
134PAK20.38045208
135SRC0.37614442
136RIPK10.37218308
137PDGFRB0.37179549
138ICK0.36351737
139RPS6KA20.35610943
140DAPK10.34943337
141NEK10.34091868
142IGF1R0.31932064
143CSNK1A1L0.31387722
144MAPK90.30739062
145CAMK2B0.30179336
146ILK0.30165085
147PKN20.28708672

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.93045184
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74247280
3Fatty acid biosynthesis_Homo sapiens_hsa000612.48825078
4Nitrogen metabolism_Homo sapiens_hsa009102.44829155
5Other glycan degradation_Homo sapiens_hsa005112.33433668
6GABAergic synapse_Homo sapiens_hsa047272.28637072
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.23541014
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.17354379
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07471657
10Synaptic vesicle cycle_Homo sapiens_hsa047212.06587574
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01888040
12Glutamatergic synapse_Homo sapiens_hsa047241.94791914
13Lysosome_Homo sapiens_hsa041421.94004453
14Circadian entrainment_Homo sapiens_hsa047131.84544641
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77969951
16Long-term potentiation_Homo sapiens_hsa047201.77103947
17Gastric acid secretion_Homo sapiens_hsa049711.76911831
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76060096
19Salivary secretion_Homo sapiens_hsa049701.70393865
20Insulin secretion_Homo sapiens_hsa049111.69068279
21Olfactory transduction_Homo sapiens_hsa047401.66156226
22Cocaine addiction_Homo sapiens_hsa050301.61933639
23Morphine addiction_Homo sapiens_hsa050321.61903850
24Amphetamine addiction_Homo sapiens_hsa050311.60813130
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55653879
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55345472
27Melanogenesis_Homo sapiens_hsa049161.51148353
28B cell receptor signaling pathway_Homo sapiens_hsa046621.47050559
29Dopaminergic synapse_Homo sapiens_hsa047281.47039400
30Axon guidance_Homo sapiens_hsa043601.45242952
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.41948085
32Gap junction_Homo sapiens_hsa045401.41934319
33Basal cell carcinoma_Homo sapiens_hsa052171.35791411
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33838721
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33733230
36Cholinergic synapse_Homo sapiens_hsa047251.30649543
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27808365
38Hedgehog signaling pathway_Homo sapiens_hsa043401.22224377
39Long-term depression_Homo sapiens_hsa047301.21476444
40Glioma_Homo sapiens_hsa052141.19524118
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16594227
42Bile secretion_Homo sapiens_hsa049761.14807230
43GnRH signaling pathway_Homo sapiens_hsa049121.14651879
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14352743
45Estrogen signaling pathway_Homo sapiens_hsa049151.12780733
46Renin secretion_Homo sapiens_hsa049241.11842118
47Calcium signaling pathway_Homo sapiens_hsa040201.06675772
48Hippo signaling pathway_Homo sapiens_hsa043901.05593481
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04182482
50Dorso-ventral axis formation_Homo sapiens_hsa043201.03936605
51Serotonergic synapse_Homo sapiens_hsa047261.03616942
52Taste transduction_Homo sapiens_hsa047420.99488944
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99268632
54VEGF signaling pathway_Homo sapiens_hsa043700.98398532
55Oxytocin signaling pathway_Homo sapiens_hsa049210.97071386
56ErbB signaling pathway_Homo sapiens_hsa040120.96271960
57Endometrial cancer_Homo sapiens_hsa052130.93407610
58Wnt signaling pathway_Homo sapiens_hsa043100.92817409
59cAMP signaling pathway_Homo sapiens_hsa040240.91087524
60Thyroid hormone synthesis_Homo sapiens_hsa049180.89839097
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87918479
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86797327
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86731688
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84096197
65Fatty acid metabolism_Homo sapiens_hsa012120.83742927
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83315206
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83119370
68Dilated cardiomyopathy_Homo sapiens_hsa054140.82389112
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81863692
70Sphingolipid metabolism_Homo sapiens_hsa006000.81743060
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.80670197
72Bladder cancer_Homo sapiens_hsa052190.80124625
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79403215
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79181477
75Inositol phosphate metabolism_Homo sapiens_hsa005620.78791386
76Rheumatoid arthritis_Homo sapiens_hsa053230.77824612
77Pancreatic secretion_Homo sapiens_hsa049720.76799132
78Non-small cell lung cancer_Homo sapiens_hsa052230.75631217
79Rap1 signaling pathway_Homo sapiens_hsa040150.75325614
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73358764
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72945068
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72208468
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72198991
84Notch signaling pathway_Homo sapiens_hsa043300.71745665
85Butanoate metabolism_Homo sapiens_hsa006500.69692517
86Phagosome_Homo sapiens_hsa041450.69547325
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68898681
88Colorectal cancer_Homo sapiens_hsa052100.68817018
89Melanoma_Homo sapiens_hsa052180.68627287
90Circadian rhythm_Homo sapiens_hsa047100.68506799
91Ovarian steroidogenesis_Homo sapiens_hsa049130.67430257
92Prolactin signaling pathway_Homo sapiens_hsa049170.66556674
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.66213453
94Glucagon signaling pathway_Homo sapiens_hsa049220.66070656
95Proteoglycans in cancer_Homo sapiens_hsa052050.65767370
96ECM-receptor interaction_Homo sapiens_hsa045120.65651796
97Mineral absorption_Homo sapiens_hsa049780.64869403
98Hepatitis B_Homo sapiens_hsa051610.64795571
99Steroid biosynthesis_Homo sapiens_hsa001000.64272479
100Focal adhesion_Homo sapiens_hsa045100.62899230
101Prion diseases_Homo sapiens_hsa050200.62692876
102Type II diabetes mellitus_Homo sapiens_hsa049300.59413111
103Tight junction_Homo sapiens_hsa045300.59017555
104Tuberculosis_Homo sapiens_hsa051520.58994934
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58652751
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.58364708
107Vitamin B6 metabolism_Homo sapiens_hsa007500.57973568
108Renal cell carcinoma_Homo sapiens_hsa052110.57295623
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56741240
110Insulin signaling pathway_Homo sapiens_hsa049100.56620312
111MAPK signaling pathway_Homo sapiens_hsa040100.56133653
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55071048
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54178460
114Fructose and mannose metabolism_Homo sapiens_hsa000510.54052216
115Protein digestion and absorption_Homo sapiens_hsa049740.53664038
116Choline metabolism in cancer_Homo sapiens_hsa052310.53657179
117AMPK signaling pathway_Homo sapiens_hsa041520.51922409
118Adherens junction_Homo sapiens_hsa045200.51607154
119Influenza A_Homo sapiens_hsa051640.50896310
120Vibrio cholerae infection_Homo sapiens_hsa051100.50263796
121Oocyte meiosis_Homo sapiens_hsa041140.49345003
122Ras signaling pathway_Homo sapiens_hsa040140.48933253
123HIF-1 signaling pathway_Homo sapiens_hsa040660.48874307
124Collecting duct acid secretion_Homo sapiens_hsa049660.48667679
125ABC transporters_Homo sapiens_hsa020100.48235142
126Toxoplasmosis_Homo sapiens_hsa051450.48120936
127mTOR signaling pathway_Homo sapiens_hsa041500.47884703
128Alcoholism_Homo sapiens_hsa050340.46822421
129Cardiac muscle contraction_Homo sapiens_hsa042600.45401642
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.44582858
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43860262
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43456416

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