SLC17A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.75741506
2L-phenylalanine catabolic process (GO:0006559)5.75741506
3L-phenylalanine metabolic process (GO:0006558)5.15415707
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.15415707
5aromatic amino acid family catabolic process (GO:0009074)5.05152765
6bile acid biosynthetic process (GO:0006699)4.54924611
7tryptophan catabolic process (GO:0006569)4.49090781
8indole-containing compound catabolic process (GO:0042436)4.49090781
9indolalkylamine catabolic process (GO:0046218)4.49090781
10oligosaccharide catabolic process (GO:0009313)4.47379798
11fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36958452
12tryptophan metabolic process (GO:0006568)4.20473379
13cellular response to vitamin D (GO:0071305)4.17691588
14aldehyde catabolic process (GO:0046185)4.07073961
15glycosphingolipid catabolic process (GO:0046479)4.05917598
16regulation of mononuclear cell migration (GO:0071675)4.04326267
17cellular response to vitamin (GO:0071295)3.81741692
18alpha-linolenic acid metabolic process (GO:0036109)3.75105272
19glycolipid catabolic process (GO:0019377)3.67430583
20aromatic amino acid family metabolic process (GO:0009072)3.64399776
21glyoxylate metabolic process (GO:0046487)3.62789328
22kynurenine metabolic process (GO:0070189)3.62169645
23cell adhesion mediated by integrin (GO:0033627)3.59495647
24bile acid metabolic process (GO:0008206)3.58320844
25regulation of cholesterol esterification (GO:0010872)3.54848825
26amine catabolic process (GO:0009310)3.48901110
27cellular biogenic amine catabolic process (GO:0042402)3.48901110
28keratan sulfate catabolic process (GO:0042340)3.48645237
29virion attachment to host cell (GO:0019062)3.48623184
30adhesion of symbiont to host cell (GO:0044650)3.48623184
31cysteine metabolic process (GO:0006534)3.46327071
32skin morphogenesis (GO:0043589)3.39825042
33tyrosine metabolic process (GO:0006570)3.39590243
34ceramide catabolic process (GO:0046514)3.37329841
35peroxisome fission (GO:0016559)3.35827735
36protein localization to endosome (GO:0036010)3.31051753
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30108620
38response to lipoprotein particle (GO:0055094)3.27614756
39indolalkylamine metabolic process (GO:0006586)3.27605248
40drug transmembrane transport (GO:0006855)3.24654005
41response to hepatocyte growth factor (GO:0035728)3.21443517
42cellular response to hepatocyte growth factor stimulus (GO:0035729)3.21443517
43regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.20272295
44regulation of integrin-mediated signaling pathway (GO:2001044)3.19338544
45macroautophagy (GO:0016236)3.18847994
46response to vitamin D (GO:0033280)3.18112233
47eosinophil chemotaxis (GO:0048245)3.15409984
48positive regulation of calcium ion import (GO:0090280)3.12509724
49cellular ketone body metabolic process (GO:0046950)3.12454451
50homocysteine metabolic process (GO:0050667)3.12319954
51urate metabolic process (GO:0046415)3.09820864
52opsonization (GO:0008228)3.09689832
53axon ensheathment in central nervous system (GO:0032291)3.04151419
54central nervous system myelination (GO:0022010)3.04151419
55regulation of metalloenzyme activity (GO:0048552)3.02794959
56high-density lipoprotein particle remodeling (GO:0034375)3.02273611
57sequestering of extracellular ligand from receptor (GO:0035581)3.02271564
58regulation of protein activation cascade (GO:2000257)3.00661300
59regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99590863
60uronic acid metabolic process (GO:0006063)2.98964413
61glucuronate metabolic process (GO:0019585)2.98964413
62low-density lipoprotein particle remodeling (GO:0034374)2.98379386
63positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.97669443
64coenzyme catabolic process (GO:0009109)2.97125856
65short-chain fatty acid metabolic process (GO:0046459)2.95917222
66protein carboxylation (GO:0018214)2.94341705
67peptidyl-glutamic acid carboxylation (GO:0017187)2.94341705
68alpha-amino acid catabolic process (GO:1901606)2.93526811
69membrane lipid catabolic process (GO:0046466)2.92603638
70apoptotic cell clearance (GO:0043277)2.92571843
71adhesion of symbiont to host (GO:0044406)2.91474413
72sphingolipid catabolic process (GO:0030149)2.90207036
73plasma lipoprotein particle remodeling (GO:0034369)2.89622982
74protein-lipid complex remodeling (GO:0034368)2.89622982
75macromolecular complex remodeling (GO:0034367)2.89622982
76regulation of fibrinolysis (GO:0051917)2.88609769
77negative regulation of protein activation cascade (GO:2000258)2.87457987
78fatty acid elongation (GO:0030497)2.87186074
79Golgi transport vesicle coating (GO:0048200)2.86214487
80COPI coating of Golgi vesicle (GO:0048205)2.86214487
81sphingosine metabolic process (GO:0006670)2.84584356
82barbed-end actin filament capping (GO:0051016)2.84544198
83regulation of complement activation (GO:0030449)2.84391292
84regulation of macrophage chemotaxis (GO:0010758)2.84361592
85phospholipid efflux (GO:0033700)2.83494077
86cholesterol efflux (GO:0033344)2.82427753
87drug catabolic process (GO:0042737)2.81725716
88very long-chain fatty acid metabolic process (GO:0000038)2.79537061
89peptide catabolic process (GO:0043171)2.78808105
90eosinophil migration (GO:0072677)2.76666883
91complement activation, alternative pathway (GO:0006957)2.75431688
92nonribosomal peptide biosynthetic process (GO:0019184)2.75369710
93angiotensin maturation (GO:0002003)2.74711471
94positive regulation of cellular amine metabolic process (GO:0033240)2.74509550
95cofactor catabolic process (GO:0051187)2.74267689
96amino-acid betaine metabolic process (GO:0006577)2.74015855
97NAD biosynthetic process (GO:0009435)2.72767123
98dicarboxylic acid catabolic process (GO:0043649)2.72428672
99sulfur amino acid catabolic process (GO:0000098)2.71242754
100ketone body metabolic process (GO:1902224)2.70434106
101reverse cholesterol transport (GO:0043691)2.70420983
102amino sugar catabolic process (GO:0046348)2.70416022
103cellular amino acid catabolic process (GO:0009063)2.69436058
104indole-containing compound metabolic process (GO:0042430)2.69337280
105drug transport (GO:0015893)2.69302142
106L-ascorbic acid metabolic process (GO:0019852)2.69274501
107nitrogen cycle metabolic process (GO:0071941)2.68105242
108glutamate metabolic process (GO:0006536)2.68044207
109urea metabolic process (GO:0019627)2.67228833
110urea cycle (GO:0000050)2.67228833
111serine family amino acid catabolic process (GO:0009071)2.66546416
112glutathione biosynthetic process (GO:0006750)2.65496386
113cellular glucuronidation (GO:0052695)2.65271726
114fibrinolysis (GO:0042730)2.65247470
115negative regulation of complement activation (GO:0045916)2.64715894
116bile acid and bile salt transport (GO:0015721)2.64245825
117exogenous drug catabolic process (GO:0042738)2.61600749
118cellular modified amino acid catabolic process (GO:0042219)2.61202107
119blood coagulation, intrinsic pathway (GO:0007597)2.59488418
120organic acid catabolic process (GO:0016054)2.59269221
121carboxylic acid catabolic process (GO:0046395)2.59269221
122response to parathyroid hormone (GO:0071107)2.58090510
123negative regulation of lipase activity (GO:0060192)2.57463108
124monocarboxylic acid catabolic process (GO:0072329)2.55205605
125cellular response to nutrient (GO:0031670)2.54372121
126nucleotide transmembrane transport (GO:1901679)2.54264113
127benzene-containing compound metabolic process (GO:0042537)2.52693637
128lipid oxidation (GO:0034440)2.52181069
129fatty acid oxidation (GO:0019395)2.51877287
130glycoside metabolic process (GO:0016137)2.51575042
131flavonoid metabolic process (GO:0009812)2.50238252
132fatty acid catabolic process (GO:0009062)2.49876053
133cellular response to thyroid hormone stimulus (GO:0097067)2.49222798
134regulation of cholesterol homeostasis (GO:2000188)2.48803415
135amyloid precursor protein catabolic process (GO:0042987)2.47489454
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.47287864
137negative regulation of coagulation (GO:0050819)2.45714914
138regulation of transforming growth factor beta1 production (GO:0032908)2.45550031
139lysosome organization (GO:0007040)2.44592595
140lytic vacuole organization (GO:0080171)2.44592595
141transcytosis (GO:0045056)2.44425537
142fatty acid beta-oxidation (GO:0006635)2.43229744
143response to thyroid hormone (GO:0097066)2.43052554
144fat-soluble vitamin biosynthetic process (GO:0042362)2.42804139
145transferrin transport (GO:0033572)2.41996473
146negative regulation of fibrinolysis (GO:0051918)2.41869543
147protein activation cascade (GO:0072376)2.41732936
148acylglycerol homeostasis (GO:0055090)2.41002109
149triglyceride homeostasis (GO:0070328)2.41002109
150mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.40544014
151positive regulation of extracellular matrix organization (GO:1903055)2.40492423
152negative regulation of wound healing (GO:0061045)2.39848514
153diol metabolic process (GO:0034311)2.39671151
154COPII vesicle coating (GO:0048208)2.38144868
155substrate-dependent cell migration (GO:0006929)2.37263912
156regulation of triglyceride catabolic process (GO:0010896)2.36589191
157regulation of cholesterol storage (GO:0010885)2.36317595
158extracellular regulation of signal transduction (GO:1900115)2.36261823
159extracellular negative regulation of signal transduction (GO:1900116)2.36261823
160plasma lipoprotein particle clearance (GO:0034381)2.36015067
161vasodilation (GO:0042311)2.35719924
162response to phenylpropanoid (GO:0080184)2.35668832
163iron ion import (GO:0097286)2.35225205
164bone resorption (GO:0045453)2.34911962
165sphingoid metabolic process (GO:0046519)2.34763824
166very-low-density lipoprotein particle assembly (GO:0034379)2.34652279
167N-acetylneuraminate metabolic process (GO:0006054)2.34096300
168negative regulation of blood coagulation (GO:0030195)2.33902772
169negative regulation of hemostasis (GO:1900047)2.33902772
170endosome to melanosome transport (GO:0035646)2.32944906
171endosome to pigment granule transport (GO:0043485)2.32944906
172decidualization (GO:0046697)2.31279184
173negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.30664131
174protein maturation by protein folding (GO:0022417)2.29881178
175membrane raft organization (GO:0031579)2.29772586
176positive regulation of leukocyte degranulation (GO:0043302)2.28920887
177positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28036844
178regulation of extracellular matrix disassembly (GO:0010715)2.26553564
179ferric iron transport (GO:0015682)2.25457313
180trivalent inorganic cation transport (GO:0072512)2.25457313
181regulation of type B pancreatic cell apoptotic process (GO:2000674)2.23873114
182hyaluronan catabolic process (GO:0030214)2.22667431
183viral entry into host cell (GO:0046718)2.22587168
184nitric oxide biosynthetic process (GO:0006809)2.22504756
185xenobiotic catabolic process (GO:0042178)2.20791546
186negative regulation of protein localization to plasma membrane (GO:1903077)2.20719454
187response to lead ion (GO:0010288)2.20176206
188regulation of collagen metabolic process (GO:0010712)2.19376658
189sphingomyelin metabolic process (GO:0006684)2.18937006
190intracellular pH reduction (GO:0051452)2.16992280
191positive regulation of coagulation (GO:0050820)2.15439068
192endodermal cell differentiation (GO:0035987)2.14495708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63477189
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18090336
3GBX2_23144817_ChIP-Seq_PC3_Human3.15037932
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.79596876
5TAF15_26573619_Chip-Seq_HEK293_Human2.79537236
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.58724198
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.51687810
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.47029514
9VDR_22108803_ChIP-Seq_LS180_Human2.34328895
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23355021
11CJUN_26792858_Chip-Seq_BT549_Human2.22297209
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.20909739
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19479308
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16363002
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.11182211
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10097064
17* SOX2_20726797_ChIP-Seq_SW620_Human2.06170498
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04795242
19EZH2_22144423_ChIP-Seq_EOC_Human2.01172288
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.99912587
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94284731
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92470255
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.87212380
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86697567
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85202733
26P300_19829295_ChIP-Seq_ESCs_Human1.84824926
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84646128
28JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81748363
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81060316
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79454981
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78861768
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76915433
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76253354
34JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73609727
35BRD4_25478319_ChIP-Seq_HGPS_Human1.72546139
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72477293
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69933830
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69292509
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68539811
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68197856
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.67437825
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.67433989
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67228653
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.66786028
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65716339
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65504162
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.62423861
48* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61572426
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58975427
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58058125
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57845216
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57690496
53TFEB_21752829_ChIP-Seq_HELA_Human1.57529654
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.57243346
55* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57238387
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56977936
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56652379
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55839225
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53133127
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51714631
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49849748
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49849748
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.48795044
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48693767
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47140975
66VDR_24787735_ChIP-Seq_THP-1_Human1.46889625
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45484677
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44657509
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.43966458
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43628556
71SMAD4_21799915_ChIP-Seq_A2780_Human1.43564131
72ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.43173220
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.42443547
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42379583
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42379583
76HTT_18923047_ChIP-ChIP_STHdh_Human1.42149608
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41307491
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41307491
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38669455
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.38662278
81CLOCK_20551151_ChIP-Seq_293T_Human1.38326053
82ER_23166858_ChIP-Seq_MCF-7_Human1.36850328
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.35671376
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34864248
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34166036
86* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33152201
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32324512
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.32235366
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31712913
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.31434262
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.31196416
92GATA4_25053715_ChIP-Seq_YYC3_Human1.30903406
93AR_21572438_ChIP-Seq_LNCaP_Human1.29663307
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27937008
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27330416
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25434436
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.24442482
98P53_22387025_ChIP-Seq_ESCs_Mouse1.24374068
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24076450
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.22416677
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21687360
102BCAT_22108803_ChIP-Seq_LS180_Human1.21274829
103TP53_18474530_ChIP-ChIP_U2OS_Human1.20565157
104TP63_23658742_ChIP-Seq_EP156T_Human1.20060645
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19990530
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19900963
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19867193
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19043564
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.18766471
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18578183
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17996917
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17648245
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.17531836
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.17113664
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.15511174
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.14981614
117P300_18555785_Chip-Seq_ESCs_Mouse1.14674793
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14056019
119CDX2_22108803_ChIP-Seq_LS180_Human1.13816068
120FLI1_27457419_Chip-Seq_LIVER_Mouse1.13479858
121SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13419013
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12916642
123TAL1_26923725_Chip-Seq_HPCs_Mouse1.12428160
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.10967562
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10263720
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10128365
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09980603
128AR_25329375_ChIP-Seq_VCAP_Human1.09744957
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09329784
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09244902
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08216064
132TP53_16413492_ChIP-PET_HCT116_Human1.08181654
133SOX2_18555785_Chip-Seq_ESCs_Mouse1.07591005
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05385060
135NMYC_18555785_Chip-Seq_ESCs_Mouse1.04923139
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03795024
137NANOG_19829295_ChIP-Seq_ESCs_Human1.03749286
138SOX2_19829295_ChIP-Seq_ESCs_Human1.03749286
139KDM2B_26808549_Chip-Seq_REH_Human1.02941020
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02871158
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02238472
142ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01825501
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00988684
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00978119
145PU1_27457419_Chip-Seq_LIVER_Mouse1.00940060
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00427013
147OCT4_18555785_Chip-Seq_ESCs_Mouse1.00223093
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98371425
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.98253593
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97467082
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97188714
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96343657
153ZFX_18555785_Chip-Seq_ESCs_Mouse0.96287844
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.95988948
155IRF8_21731497_ChIP-ChIP_J774_Mouse0.95947332
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.95728615
157FOXA2_19822575_ChIP-Seq_HepG2_Human0.93467038
158GATA3_24758297_ChIP-Seq_MCF-7_Human0.91352537
159RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91311026
160PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89134356
161* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89070823
162PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88151293
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87446844
164EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86744562
165STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86142293
166EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84242022
167SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83479847
168NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81460840
169CBP_21632823_ChIP-Seq_H3396_Human0.81229087
170* AHR_22903824_ChIP-Seq_MCF-7_Human0.80551557
171NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80387314
172AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79048584
173NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78747291
174NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78622343
175* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77972608
176* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77277463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.24040691
2MP0002139_abnormal_hepatobiliary_system4.92790284
3MP0005085_abnormal_gallbladder_physiolo3.84997850
4MP0005365_abnormal_bile_salt3.73270953
5MP0008438_abnormal_cutaneous_collagen3.47144887
6MP0008875_abnormal_xenobiotic_pharmacok3.43996654
7MP0000678_abnormal_parathyroid_gland3.19374536
8MP0003195_calcinosis3.10450620
9MP0003880_abnormal_central_pattern2.74481914
10MP0006054_spinal_hemorrhage2.67257199
11MP0005332_abnormal_amino_acid2.58498390
12MP0005083_abnormal_biliary_tract2.58136920
13MP0003950_abnormal_plasma_membrane2.44065698
14MP0004272_abnormal_basement_membrane2.41954353
15MP0005257_abnormal_intraocular_pressure2.38680151
16MP0004019_abnormal_vitamin_homeostasis2.29774015
17MP0002876_abnormal_thyroid_physiology2.19961459
18MP0000343_altered_response_to2.04314362
19MP0001666_abnormal_nutrient_absorption2.03111662
20MP0006276_abnormal_autonomic_nervous1.91851085
21MP0000516_abnormal_urinary_system1.88164742
22MP0005367_renal/urinary_system_phenotyp1.88164742
23MP0003252_abnormal_bile_duct1.87176078
24MP0002877_abnormal_melanocyte_morpholog1.83725858
25MP0005451_abnormal_body_composition1.79427535
26MP0002138_abnormal_hepatobiliary_system1.79039781
27MP0010329_abnormal_lipoprotein_level1.77986636
28MP0005058_abnormal_lysosome_morphology1.76714240
29MP0009840_abnormal_foam_cell1.73918655
30MP0002896_abnormal_bone_mineralization1.69138745
31MP0000604_amyloidosis1.66228631
32MP0001958_emphysema1.64982940
33MP0003279_aneurysm1.63457252
34MP0000566_synostosis1.62458541
35MP0002736_abnormal_nociception_after1.62292281
36MP0002254_reproductive_system_inflammat1.62180359
37MP0003300_gastrointestinal_ulcer1.60915395
38MP0005464_abnormal_platelet_physiology1.60749531
39MP0008004_abnormal_stomach_pH1.58453776
40MP0009697_abnormal_copulation1.56940895
41MP0005165_increased_susceptibility_to1.55684432
42MP0005084_abnormal_gallbladder_morpholo1.55395624
43MP0002735_abnormal_chemical_nociception1.54973517
44MP0003566_abnormal_cell_adhesion1.51137449
45MP0003191_abnormal_cellular_cholesterol1.47931591
46MP0010386_abnormal_urinary_bladder1.47684606
47MP0001968_abnormal_touch/_nociception1.47536357
48MP0003329_amyloid_beta_deposits1.45558613
49MP0004381_abnormal_hair_follicle1.44536007
50MP0003806_abnormal_nucleotide_metabolis1.44435792
51MP0002909_abnormal_adrenal_gland1.43343340
52MP0002998_abnormal_bone_remodeling1.39451721
53MP0003075_altered_response_to1.37073888
54MP0003690_abnormal_glial_cell1.36255050
55* MP0000920_abnormal_myelination1.32697469
56MP0004270_analgesia1.31351882
57MP0001440_abnormal_grooming_behavior1.31058610
58MP0005636_abnormal_mineral_homeostasis1.31023999
59MP0002118_abnormal_lipid_homeostasis1.28518017
60MP0002168_other_aberrant_phenotype1.28053484
61MP0009643_abnormal_urine_homeostasis1.28046931
62MP0003724_increased_susceptibility_to1.27513187
63MP0001533_abnormal_skeleton_physiology1.25269468
64MP0009745_abnormal_behavioral_response1.22633576
65MP0004742_abnormal_vestibular_system1.21208007
66MP0009764_decreased_sensitivity_to1.20209915
67MP0005164_abnormal_response_to1.19546373
68MP0001764_abnormal_homeostasis1.19453814
69MP0003868_abnormal_feces_composition1.18339017
70MP0004510_myositis1.18322805
71MP0002837_dystrophic_cardiac_calcinosis1.18229464
72* MP0002064_seizures1.17307384
73MP0005275_abnormal_skin_tensile1.16561630
74MP0003183_abnormal_peptide_metabolism1.16509171
75MP0001905_abnormal_dopamine_level1.15759776
76MP0004043_abnormal_pH_regulation1.14322485
77MP0003303_peritoneal_inflammation1.13118004
78MP0001486_abnormal_startle_reflex1.11361286
79MP0001765_abnormal_ion_homeostasis1.10776666
80MP0002148_abnormal_hypersensitivity_rea1.10438928
81MP0010352_gastrointestinal_tract_polyps1.10186827
82MP0000538_abnormal_urinary_bladder1.09934139
83MP0009785_altered_susceptibility_to1.08550300
84MP0005023_abnormal_wound_healing1.07803813
85MP0000013_abnormal_adipose_tissue1.06751500
86MP0000569_abnormal_digit_pigmentation1.06657531
87MP0005646_abnormal_pituitary_gland1.06381274
88MP0005584_abnormal_enzyme/coenzyme_acti1.02823243
89* MP0002572_abnormal_emotion/affect_behav1.02108942
90MP0001501_abnormal_sleep_pattern1.02036009
91MP0003091_abnormal_cell_migration1.01025751
92MP0003186_abnormal_redox_activity1.00701130
93MP0002272_abnormal_nervous_system1.00132044
94MP0003795_abnormal_bone_structure0.99513703
95MP0005535_abnormal_body_temperature0.99406052
96MP0010368_abnormal_lymphatic_system0.97579108
97MP0005409_darkened_coat_color0.96416229
98MP0002734_abnormal_mechanical_nocicepti0.96401860
99MP0000015_abnormal_ear_pigmentation0.96111225
100MP0005390_skeleton_phenotype0.95483401
101MP0005408_hypopigmentation0.95079357
102MP0009780_abnormal_chondrocyte_physiolo0.94437337
103MP0005508_abnormal_skeleton_morphology0.92664628
104MP0000858_altered_metastatic_potential0.92072786
105MP0005379_endocrine/exocrine_gland_phen0.91579133
106MP0005166_decreased_susceptibility_to0.89763619
107MP0005167_abnormal_blood-brain_barrier0.89435293
108MP0003448_altered_tumor_morphology0.87640074
109MP0000767_abnormal_smooth_muscle0.87197994
110MP0001188_hyperpigmentation0.85422518
111MP0002067_abnormal_sensory_capabilities0.85101894
112MP0003436_decreased_susceptibility_to0.84672892
113MP0000609_abnormal_liver_physiology0.84180839
114MP0005319_abnormal_enzyme/_coenzyme0.83532791
115MP0009046_muscle_twitch0.82649332
116MP0001970_abnormal_pain_threshold0.81967320
117MP0002733_abnormal_thermal_nociception0.81484416
118MP0005395_other_phenotype0.81208472
119MP0002090_abnormal_vision0.80777296
120MP0000249_abnormal_blood_vessel0.80135048
121MP0008469_abnormal_protein_level0.79718536
122MP0006082_CNS_inflammation0.79611270
123MP0002136_abnormal_kidney_physiology0.79264059
124MP0003635_abnormal_synaptic_transmissio0.79047233
125MP0001243_abnormal_dermal_layer0.78637461
126MP0004142_abnormal_muscle_tone0.77566772
127MP0003172_abnormal_lysosome_physiology0.77454686
128MP0001756_abnormal_urination0.77249871
129MP0005171_absent_coat_pigmentation0.76853925
130MP0003136_yellow_coat_color0.76040633
131MP0002971_abnormal_brown_adipose0.75083399
132MP0001984_abnormal_olfaction0.75037497
133MP0005595_abnormal_vascular_smooth0.75015863
134MP0010234_abnormal_vibrissa_follicle0.74043620
135MP0004782_abnormal_surfactant_physiolog0.73736122
136MP0001845_abnormal_inflammatory_respons0.73555271
137* MP0001963_abnormal_hearing_physiology0.73029387
138MP0002419_abnormal_innate_immunity0.72084043
139* MP0002063_abnormal_learning/memory/cond0.71304860
140MP0000371_diluted_coat_color0.70603602
141MP0000230_abnormal_systemic_arterial0.70548016
142MP0008260_abnormal_autophagy0.70314341
143MP0008874_decreased_physiological_sensi0.70178176
144MP0005647_abnormal_sex_gland0.69958505
145MP0002295_abnormal_pulmonary_circulatio0.69760965
146MP0002229_neurodegeneration0.69292372
147MP0003045_fibrosis0.68675723
148MP0005423_abnormal_somatic_nervous0.68120535
149MP0001529_abnormal_vocalization0.67994060
150MP0005503_abnormal_tendon_morphology0.67465640
151MP0001986_abnormal_taste_sensitivity0.66825237
152MP0009642_abnormal_blood_homeostasis0.66450676
153MP0001661_extended_life_span0.66316246
154MP0000026_abnormal_inner_ear0.66198367
155MP0003828_pulmonary_edema0.66167331
156MP0004484_altered_response_of0.65752930
157MP0003879_abnormal_hair_cell0.65216723
158MP0001542_abnormal_bone_strength0.64989059
159* MP0003633_abnormal_nervous_system0.64663169

Predicted human phenotypes

RankGene SetZ-score
1Hyperphosphatemia (HP:0002905)5.36919098
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.72443507
3Prolonged partial thromboplastin time (HP:0003645)4.38604611
4Dysostosis multiplex (HP:0000943)4.32256361
5Premature rupture of membranes (HP:0001788)3.95781111
6Abnormality of polysaccharide metabolism (HP:0011012)3.93908860
7Abnormality of glycosaminoglycan metabolism (HP:0004371)3.93908860
8Abnormality of mucopolysaccharide metabolism (HP:0011020)3.93908860
9Urinary glycosaminoglycan excretion (HP:0003541)3.82150538
10Mucopolysacchariduria (HP:0008155)3.82150538
11Intrahepatic cholestasis (HP:0001406)3.68137436
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.47047803
13Xanthomatosis (HP:0000991)3.42329256
14Joint hemorrhage (HP:0005261)3.33499775
15Hyperlipoproteinemia (HP:0010980)3.25175178
16Loss of speech (HP:0002371)3.23346185
17Deep venous thrombosis (HP:0002625)3.22377669
18* Conjugated hyperbilirubinemia (HP:0002908)3.18823481
19Abnormality of calcium-phosphate metabolism (HP:0100530)3.17193105
20Increased cerebral lipofuscin (HP:0011813)3.14209568
21Hyperventilation (HP:0002883)3.08606492
22Neurofibrillary tangles (HP:0002185)3.07886594
23Systemic lupus erythematosus (HP:0002725)3.07407860
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.02585168
25Complement deficiency (HP:0004431)2.96323359
26Fat malabsorption (HP:0002630)2.93055086
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90038540
28Myocardial infarction (HP:0001658)2.88143137
29Hypomagnesemia (HP:0002917)2.87468360
30Renal Fanconi syndrome (HP:0001994)2.86876164
31Progressive neurologic deterioration (HP:0002344)2.81290802
32Increased circulating renin level (HP:0000848)2.77641630
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76617101
34Parakeratosis (HP:0001036)2.71083779
35Abnormality of renal resorption (HP:0011038)2.70503226
36Tetraparesis (HP:0002273)2.69324071
37Metabolic alkalosis (HP:0200114)2.68302718
38Vertebral compression fractures (HP:0002953)2.67502100
39Nuclear cataract (HP:0100018)2.65868279
40Glycosuria (HP:0003076)2.65798873
41Abnormality of urine glucose concentration (HP:0011016)2.65798873
42Prolonged neonatal jaundice (HP:0006579)2.64436336
43Steatorrhea (HP:0002570)2.60155543
44Mitral stenosis (HP:0001718)2.58168877
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.55833350
46Hyperglycinemia (HP:0002154)2.54626700
47* Metaphyseal irregularity (HP:0003025)2.53961949
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53201445
49Abnormality of macrophages (HP:0004311)2.53095287
50Alkalosis (HP:0001948)2.51696870
51Protrusio acetabuli (HP:0003179)2.48965252
52Abnormality of glycine metabolism (HP:0010895)2.47359105
53Abnormality of serine family amino acid metabolism (HP:0010894)2.47359105
54Ketosis (HP:0001946)2.46915304
55Abnormality of proline metabolism (HP:0010907)2.46820115
56Hydroxyprolinuria (HP:0003080)2.46820115
57Hyperglycinuria (HP:0003108)2.46408565
58Cerebral edema (HP:0002181)2.44859968
593-Methylglutaconic aciduria (HP:0003535)2.43255147
60Abnormality of methionine metabolism (HP:0010901)2.43108934
61Acute encephalopathy (HP:0006846)2.42925628
62Epidermoid cyst (HP:0200040)2.41944846
63* Vacuolated lymphocytes (HP:0001922)2.41906013
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.38200275
65Hypokalemic alkalosis (HP:0001949)2.37014718
66Vascular tortuosity (HP:0004948)2.37000586
67Hypobetalipoproteinemia (HP:0003563)2.35927344
68Cerebral inclusion bodies (HP:0100314)2.34660485
69Amyloidosis (HP:0011034)2.33891414
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.33512808
71Aortic dissection (HP:0002647)2.31523059
72Zonular cataract (HP:0010920)2.29430550
73Follicular hyperkeratosis (HP:0007502)2.28379582
74Hematochezia (HP:0002573)2.28175032
75Petechiae (HP:0000967)2.26576716
76Proximal tubulopathy (HP:0000114)2.26465838
77Purpura (HP:0000979)2.25880299
78Hyperammonemia (HP:0001987)2.25419162
79Disinhibition (HP:0000734)2.22320629
80Vascular calcification (HP:0004934)2.21467449
81Gout (HP:0001997)2.21437997
82Abnormality of the common coagulation pathway (HP:0010990)2.21164241
83Enlarged kidneys (HP:0000105)2.20791144
84Renal tubular dysfunction (HP:0000124)2.16635765
85Abnormality of purine metabolism (HP:0004352)2.15938349
86Abnormality of fatty-acid metabolism (HP:0004359)2.15154534
87Abnormality of magnesium homeostasis (HP:0004921)2.14408110
88Acute necrotizing encephalopathy (HP:0006965)2.14104981
89Arterial tortuosity (HP:0005116)2.13765864
90Glomerulonephritis (HP:0000099)2.12635090
91Hypophosphatemic rickets (HP:0004912)2.11318335
92Tongue fasciculations (HP:0001308)2.11289261
93Asymmetric septal hypertrophy (HP:0001670)2.10360228
94Hyperphosphaturia (HP:0003109)2.10298927
95Ovoid vertebral bodies (HP:0003300)2.09802402
96Delayed CNS myelination (HP:0002188)2.09608244
97Osteolytic defects of the phalanges of the hand (HP:0009771)2.09432231
98Osteolytic defects of the hand bones (HP:0009699)2.09432231
99Increased CSF protein (HP:0002922)2.08207410
100Tubulointerstitial nephritis (HP:0001970)2.07837516
101Protuberant abdomen (HP:0001538)2.06902668
102Confusion (HP:0001289)2.06125594
103Lethargy (HP:0001254)2.04502859
104Hypokinesia (HP:0002375)2.03308686
105Metabolic acidosis (HP:0001942)2.03043548
106Albinism (HP:0001022)2.02974312
107Abnormality of complement system (HP:0005339)2.02650164
108Recurrent corneal erosions (HP:0000495)2.02320059
109Opisthotonus (HP:0002179)2.01538098
110Hyperactive renin-angiotensin system (HP:0000841)2.01503968
111Ketoacidosis (HP:0001993)2.00043034
112Hyperparathyroidism (HP:0000843)1.99797140
113Renal tubular acidosis (HP:0001947)1.99541676
114Vomiting (HP:0002013)1.99415068
115Lipid accumulation in hepatocytes (HP:0006561)1.99350417
116Abnormality of nucleobase metabolism (HP:0010932)1.98761327
117Mutism (HP:0002300)1.98414629
118Recurrent gram-negative bacterial infections (HP:0005420)1.98168778
119Methylmalonic acidemia (HP:0002912)1.97950064
120Increased hepatocellular lipid droplets (HP:0006565)1.96887522
121Hypophosphatemia (HP:0002148)1.96583415
122Hypocalcemia (HP:0002901)1.96175225
123Cervical subluxation (HP:0003308)1.95862073
124Abnormal urine phosphate concentration (HP:0012599)1.95842471
125Progressive macrocephaly (HP:0004481)1.95381213
126Skin nodule (HP:0200036)1.95380957
127Abnormality of liposaccharide metabolism (HP:0010968)1.94707523
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.94707523
129Abnormality of glycolipid metabolism (HP:0010969)1.94707523
130* Cardiomegaly (HP:0001640)1.94520299
131Mitochondrial inheritance (HP:0001427)1.93042386
132Abnormality of renal excretion (HP:0011036)1.92924072
133Abnormal urine output (HP:0012590)1.92630642
134Conjunctival telangiectasia (HP:0000524)1.91769886
135Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90461806
136Dicarboxylic aciduria (HP:0003215)1.90461806
137Hypoglycemic coma (HP:0001325)1.89657677
138Hypothermia (HP:0002045)1.89552612
139Polyuria (HP:0000103)1.89315070
140Tetany (HP:0001281)1.88788165
141Congenital ichthyosiform erythroderma (HP:0007431)1.88656616
142Cardiovascular calcification (HP:0011915)1.86701038
143White forelock (HP:0002211)1.85382947
144Conical tooth (HP:0000698)1.85300662
145Soft skin (HP:0000977)1.84745464
146Hypoglycemic seizures (HP:0002173)1.84519943
147Axonal loss (HP:0003447)1.84341133
148Thickened helices (HP:0000391)1.84338289
149Cerebral hemorrhage (HP:0001342)1.83349952
150* Fair hair (HP:0002286)1.82946244
151Abnormality of secondary sexual hair (HP:0009888)1.81432691
152Abnormality of the axillary hair (HP:0100134)1.81432691
153Spondylolisthesis (HP:0003302)1.81108175
154Ankle contracture (HP:0006466)1.80410335
155Diminished motivation (HP:0000745)1.79531657
156Retinal atrophy (HP:0001105)1.78839133
157Muscle fibrillation (HP:0010546)1.78531361
158Joint stiffness (HP:0001387)1.78407627
159Abnormal drinking behavior (HP:0030082)1.77250693
160Polydipsia (HP:0001959)1.77250693
161Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77014959
162Gingival bleeding (HP:0000225)1.76676670
163Basal ganglia calcification (HP:0002135)1.76007036
164Rickets (HP:0002748)1.72443050
165Abnormality of renin-angiotensin system (HP:0000847)1.69250627
166Apathy (HP:0000741)1.68462860
167Malnutrition (HP:0004395)1.68355787
168Aortic aneurysm (HP:0004942)1.65055650
169Increased serum ferritin (HP:0003281)1.63207536
170Blue sclerae (HP:0000592)1.60687932
171Wormian bones (HP:0002645)1.59439173
172Upper motor neuron abnormality (HP:0002127)1.59248655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.89514434
2CASK3.11965251
3OXSR13.06088757
4MAP3K32.99022716
5PDK22.94582693
6TESK12.68785864
7LIMK12.65093502
8INSRR2.64246538
9STK392.35867984
10EPHA42.35017647
11BMPR1B2.33971008
12TIE12.13934546
13DDR22.12020476
14GRK51.95307292
15IRAK31.91727346
16MAP3K141.87797445
17RIPK41.86969933
18WNK41.84839412
19TNIK1.84147101
20EPHA21.82032941
21BMPR21.71436603
22EPHB21.68572212
23PAK41.66563014
24BCR1.64861989
25IRAK21.63535559
26GRK71.55055033
27MAP4K21.54252767
28PBK1.53399343
29ACVR1B1.53084451
30ERN11.50330651
31WNK31.49243244
32IRAK41.47087476
33ARAF1.46190907
34NTRK31.44100540
35STK38L1.43206116
36PRKG21.41488332
37RIPK11.40474545
38TRPM71.36851746
39MAP3K121.35363556
40PTK21.34410143
41BCKDK1.31892064
42IRAK11.28508073
43MAP2K71.27763472
44MAP3K131.26564211
45TAOK31.26542486
46STK381.26371416
47PLK21.22904085
48NUAK11.22673695
49FGR1.22317738
50LMTK21.20655796
51PINK11.19683219
52MAP3K51.18711511
53TXK1.18121277
54PIK3CG1.14602285
55TBK11.13881160
56PRKCE1.11743840
57NME11.11468150
58MST1R1.10639169
59CAMK2B1.09457489
60PTK2B1.09075488
61AKT31.08861694
62MAPKAPK31.07440614
63PKN11.05789466
64EPHB11.05692622
65GRK11.02632610
66MOS0.99352770
67BLK0.99055023
68GSK3A0.98269481
69SGK4940.97268739
70SGK2230.97268739
71ZAP700.94861650
72MAP3K20.92156686
73ERBB40.89804273
74TAOK10.89428657
75MST40.89397562
76PDGFRA0.89154463
77NTRK10.88102540
78CAMK2A0.87295223
79DAPK30.86414395
80MUSK0.86337444
81PRKCQ0.86114673
82ADRBK20.84523816
83MAP2K40.82610653
84DAPK20.82415577
85MET0.80224490
86SIK30.79724894
87CAMK2D0.77859429
88MAPK150.77417645
89BRAF0.76510683
90ABL20.76300275
91NEK60.74049087
92MAPK70.73515963
93MAPK130.72647385
94TRIM280.71975946
95FRK0.71565443
96FES0.70478850
97EIF2AK30.70423504
98MAPKAPK50.68501493
99CAMK2G0.68205214
100LATS20.67860338
101MAP2K60.66884562
102NEK90.66761386
103PRKCG0.65946513
104CSNK1G30.65334144
105SGK20.62489366
106TESK20.62182936
107CDC42BPA0.61903409
108NME20.61263939
109CSNK1G10.61073269
110EPHA30.60870145
111MAP3K40.60507777
112CSNK1A1L0.60253957
113GRK60.57624276
114MAP3K60.56628286
115PIM20.56213182
116FGFR20.55871775
117STK30.55589675
118PRKAA20.54869596
119ROCK10.54161265
120MYLK0.53902600
121ERBB30.53877698
122PDPK10.53825309
123TAOK20.52922856
124PHKG20.52087360
125PHKG10.52087360
126IKBKE0.51437890
127PAK20.51043554
128FLT30.50994394
129CSF1R0.49789618
130TGFBR20.49570937
131TYK20.49450578
132NEK10.48009894
133CSNK1G20.47900138
134MAPK120.47727837
135ROCK20.47446059
136PRKACA0.47291917
137ZAK0.47087015
138FGFR40.46947478
139EIF2AK20.46924109
140CDK30.46211943
141PDGFRB0.46169057
142MAP3K10.45411043
143JAK10.45021095
144PRKCZ0.44764645
145BMX0.44399697
146IGF1R0.43789934
147LATS10.43345463
148ADRBK10.42479166
149PRKCA0.42322716
150YES10.42120601
151CAMKK20.40966968
152MATK0.40921844
153FER0.40262429
154PRKG10.38027719
155PAK30.36865820
156PRKCD0.36731522

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.08687746
2Histidine metabolism_Homo sapiens_hsa003402.45789734
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43972005
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35864103
5Peroxisome_Homo sapiens_hsa041462.31432239
6Butanoate metabolism_Homo sapiens_hsa006502.18977804
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18699505
8Complement and coagulation cascades_Homo sapiens_hsa046102.16949645
9Tryptophan metabolism_Homo sapiens_hsa003802.16457014
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15692238
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09921138
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06006608
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.05723118
14Fatty acid elongation_Homo sapiens_hsa000622.01789930
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00778655
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92914313
17Steroid biosynthesis_Homo sapiens_hsa001001.84838473
18Sulfur metabolism_Homo sapiens_hsa009201.83125337
19Oxidative phosphorylation_Homo sapiens_hsa001901.82057561
20Collecting duct acid secretion_Homo sapiens_hsa049661.80829755
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78141658
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.77893375
23beta-Alanine metabolism_Homo sapiens_hsa004101.73987421
24Arginine biosynthesis_Homo sapiens_hsa002201.70064691
25Staphylococcus aureus infection_Homo sapiens_hsa051501.65856098
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64224328
27Fatty acid degradation_Homo sapiens_hsa000711.62354262
28Galactose metabolism_Homo sapiens_hsa000521.60558067
29Phenylalanine metabolism_Homo sapiens_hsa003601.58536281
30Chemical carcinogenesis_Homo sapiens_hsa052041.57449107
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54197029
32Nitrogen metabolism_Homo sapiens_hsa009101.52760404
33Retinol metabolism_Homo sapiens_hsa008301.50551494
34Propanoate metabolism_Homo sapiens_hsa006401.42354591
35Tyrosine metabolism_Homo sapiens_hsa003501.42046899
36Vitamin digestion and absorption_Homo sapiens_hsa049771.34528418
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29577530
38Protein export_Homo sapiens_hsa030601.25489653
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.21946750
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21456627
41Fatty acid metabolism_Homo sapiens_hsa012121.21088878
42Bile secretion_Homo sapiens_hsa049761.19365718
43PPAR signaling pathway_Homo sapiens_hsa033201.19127489
44Caffeine metabolism_Homo sapiens_hsa002321.17071466
45Pertussis_Homo sapiens_hsa051331.15181116
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14257361
47ECM-receptor interaction_Homo sapiens_hsa045121.11003883
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10645462
49Alzheimers disease_Homo sapiens_hsa050101.09778639
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09726994
51Arginine and proline metabolism_Homo sapiens_hsa003301.09107717
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06691424
53Protein digestion and absorption_Homo sapiens_hsa049741.04970933
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00917475
55Nicotine addiction_Homo sapiens_hsa050330.99837798
56ABC transporters_Homo sapiens_hsa020100.97216718
57Starch and sucrose metabolism_Homo sapiens_hsa005000.96517604
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96375067
59Salmonella infection_Homo sapiens_hsa051320.95913841
60Parkinsons disease_Homo sapiens_hsa050120.94129271
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.92251608
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91645620
63Sphingolipid metabolism_Homo sapiens_hsa006000.90935614
64* Lysosome_Homo sapiens_hsa041420.88711278
65Vibrio cholerae infection_Homo sapiens_hsa051100.88110892
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.85978986
67N-Glycan biosynthesis_Homo sapiens_hsa005100.85005684
68Rheumatoid arthritis_Homo sapiens_hsa053230.83743873
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.82057897
70Ether lipid metabolism_Homo sapiens_hsa005650.80427994
71Malaria_Homo sapiens_hsa051440.79785407
72Glutathione metabolism_Homo sapiens_hsa004800.79454153
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78142343
74Vitamin B6 metabolism_Homo sapiens_hsa007500.78028269
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78024562
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78014089
77Amoebiasis_Homo sapiens_hsa051460.77611621
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75434484
79Pyruvate metabolism_Homo sapiens_hsa006200.74597638
80Phagosome_Homo sapiens_hsa041450.72145529
81Other glycan degradation_Homo sapiens_hsa005110.71791064
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71219355
83Tuberculosis_Homo sapiens_hsa051520.70220576
84Metabolic pathways_Homo sapiens_hsa011000.69976711
85Legionellosis_Homo sapiens_hsa051340.69962757
86Focal adhesion_Homo sapiens_hsa045100.69277862
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69175215
88Folate biosynthesis_Homo sapiens_hsa007900.68944871
89Glycerolipid metabolism_Homo sapiens_hsa005610.67204711
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66600375
91TNF signaling pathway_Homo sapiens_hsa046680.65443172
92Arachidonic acid metabolism_Homo sapiens_hsa005900.64686115
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63708027
94Fructose and mannose metabolism_Homo sapiens_hsa000510.63003226
95Selenocompound metabolism_Homo sapiens_hsa004500.60959523
96Shigellosis_Homo sapiens_hsa051310.60558525
97Taste transduction_Homo sapiens_hsa047420.59620858
98Bladder cancer_Homo sapiens_hsa052190.59442151
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58571687
100Osteoclast differentiation_Homo sapiens_hsa043800.58392776
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56639713
102Fat digestion and absorption_Homo sapiens_hsa049750.56306513
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55815983
104Fatty acid biosynthesis_Homo sapiens_hsa000610.55489627
105Linoleic acid metabolism_Homo sapiens_hsa005910.54660140
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54323245
107Serotonergic synapse_Homo sapiens_hsa047260.53785239
108Mineral absorption_Homo sapiens_hsa049780.50678027
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50492876
110Pentose phosphate pathway_Homo sapiens_hsa000300.49727942
111Synaptic vesicle cycle_Homo sapiens_hsa047210.48461380
112Type I diabetes mellitus_Homo sapiens_hsa049400.46551959
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46255023
114Huntingtons disease_Homo sapiens_hsa050160.45161473
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44796402
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43149476
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43137719
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42708602
119GABAergic synapse_Homo sapiens_hsa047270.42704879
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42541228
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42083931
122Glutamatergic synapse_Homo sapiens_hsa047240.41928849
123Regulation of autophagy_Homo sapiens_hsa041400.41019258
124Hematopoietic cell lineage_Homo sapiens_hsa046400.40654839
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40180409
126Proteoglycans in cancer_Homo sapiens_hsa052050.40047148
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.38249590
128Endocytosis_Homo sapiens_hsa041440.37854160
129Pancreatic secretion_Homo sapiens_hsa049720.37238613
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35838512
131Toxoplasmosis_Homo sapiens_hsa051450.35110299
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34271830
133Salivary secretion_Homo sapiens_hsa049700.34017389
134Renin-angiotensin system_Homo sapiens_hsa046140.32964737
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32803011
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32768135
137Hepatitis C_Homo sapiens_hsa051600.32730017
138Graft-versus-host disease_Homo sapiens_hsa053320.32720181
139Platelet activation_Homo sapiens_hsa046110.32035008
140Prion diseases_Homo sapiens_hsa050200.31559098
141Morphine addiction_Homo sapiens_hsa050320.31128390
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.30337898
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.25609519

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